And it's kind of quaint how you know, I

went to the first Quantified Self meetup

in

whatever it was 2008 or something with

12 people sitting around in Kevin

Kelly's house talking about

measuring things with Excel

spreadsheets. The world has changed. So,

there are armies of tens of thousands of

self-described biohackers and so on

talking about longevity. There's a lot

of nonsense. For yourself personally,

where have you landed in terms of

interventions or thinking about

interventions

for yourself? I haven't done a ton. You

know, it feels like a lot collapses into

like sleep well, exercise a lot, you

know, etc. Like there's a handful of

things that kind of matter. Eat well.

Mhm. And so, I've kind of collapsed on

all that stuff. I think there's one or

two things that maybe you can take that

are helpful and then there's some things

I always thought would be fun to

experiment with that I haven't done yet.

Like what? I thought it'd be cool to try

like a rapamycin pulse or something.

Mhm. So, stuff like that, but the

reality is that I'm kind of waiting for

the real drugs to come out and then

maybe I'd use those. Some of the ones

that I actually think will really

impinge on longevity or certain systems

like we were talking earlier about as

you age, the muscle that holds the lens

of your eye weakens and that's part of

the reason that your ability to focus

kind of gets screwed up and so

there should be eye drops for that. Like

there's a bunch of stuff around

neurosensory aging that I'd love to fund

to start up.

>> Mhm. There's a bunch of stuff around the

cosmetics of aging that I've long been

talking about trying to find to actually

fund it. I clinical trial at Stanford to

to work on that for example.

>> Mhm.

Cuz I think it's very under messed in

and peptides to me is basically that.

I think a lot of those people are taking

peptides as like certain forms of

health, but also certain forms of

cosmetic applications like 5-HKCU and

melatonin and all these things are

basically cosmetic in nature. You

mentioned a handful of things that seem

helpful to take. Are those just the big,

you know, vitamin D or are we talking

about other things? What are What are

more on that short list? Vitamin D and

creatine. Yeah, got it.

>> If you want to lift. I don't know what's

on your list. I mean, you've you about

this so much more than I have.

What do you take away or what are you

thinking about or I'm much more

conservative than I think people would

expect. You know, I've

played around with a lot of things in my

earlier days and a lot of it is very, I

would say, capped risk. If you're

experimenting as I was with first

generation Dexcom continuous glucose

monitors in 2008, right? They were or

2009, very unpleasant to wear. Yeah. And

I wasn't aware of any non-type 1

diabetics using them at the time. But I

wasn't using much in terms of,

let's just say, questionable gene

therapy, flying to other countries to

use something like a follistatin. Not to

throw it under the bus, but I feel like

the general heuristic of no biological

free lunch, I recognize it's very

simplistic, but it's pretty helpful. At

least it will aid you in avoiding a lot

of pitfalls, right? So, I mean, there

are things I'm experimenting with,

different forms of ketone esters and

salts, for instance. I think some could

be very, very interesting for

cerebral vasculature. And since I have

Alzheimer's disease, Parkinson's, et

cetera in my family, including for

people who are APOE33, so there are

certainly many other risk factors, I'm

paying a lot of attention to that side

of things, you know, obeticholic I think

is one to keep an eye on that's not yet

ready for prime time, but rapamycin's

interesting. I do think rapamycin is

interesting with a lot of asterisks

because you can screw yourself up if you

don't know what you're doing.

And

I mean, if you're playing with any

immunosuppressant, I mean, you just have

to be very careful,

but

looking at combining that, for instance,

one of the experiments that I might do

is and I would have a cleaner read of

signal if I only did one intervention,

but real life is different from

Yeah. waiting for

science sometimes. Reboot. So, possibly

combining Norwegian 4 by 4 interval

training with rapamycin pulsing to look

at volumetric changes, if any, in the

hippocampus and other areas. Like, I

think that's a pretty interesting

hypothesis we're testing.

But otherwise, it's basic basic, right?

It's creatine, it's the vitamin D's.

Look, if you have methylation issues or

you're taking medication as I am, like

omeprazole, which can inhibit magnesium

absorption and other things, like you

want to keep an eye on that, but not too

fancy, you know, I think urolithin A is

pretty interesting. Mhm. The data keeps

mounting on that. I do have a keen

interest in mitochondrial health, so if

there are things, which could also

include

regular intermittent fasting and

occasional 3 to 7-day fasting, which

could be a fast-mimicking diet, most

recently for me, based on the input from

Dr. Dominic D'Agostino, trying to foster

autophagy and mitophagy with some

regularity, not all the time. Sure. I'm

not trying to optimize for that all the

time. One thing I've been wondering, so

if you look at like a computer

and often the key to fixing your laptop

or the key to fixing any system is you

just [ __ ] reboot it, right? You

reload the system and it just works

magically. Is there like a equivalent of

that? Is it like going under for

anesthesia?

Is there some nerve freezing thing that

some people have been doing recently?

Oof. Yeah, I don't know.

Sounds scary. Oh, maybe stellate

ganglion block? Yeah, that's it. The

stellate ganglion block.

>> Yeah. Yeah, I mean, the rebooting

Ah, man, I'm like letting out an exhale

because

I

There are some interesting options for

very specific use cases. It makes sense

conceptually. I mean, you're more

qualified to speak to this, but I would

say This is spending a lot of time

around neuroscientists, and I I spend a

lot of my time in terms of information

intake reading

or doing my best. Fortunately, with AI

tools, it's become a lot easier.

Not just getting a synopsis, but

actually using it to help you

learn concepts that you can kind of

layer in some

rational sequence for sure. But, I read

a lot of neuroscience stuff and a lot of

optical stuff. There's actually a

surprising amount of I mean, there's

maybe not so surprising like

very strong intersection there. So, if

you're looking at like PBM and like

photobiomodulation through the eyes, I

mean, you can do it transcranially as

well. I would give a note of caution for

that for folks, but the reboot side, I

would say for instance, and people have

experienced this to a lesser extent with

GLP-1 agonists.

If they take it for weight loss, maybe

they stop smoking, or they cut back on

drinking, or

they have these

kind of system-wide decreases or

increases in it in impulse control.

Yeah. For someone who's saying opiate

addict, I think that

ibogaine, which

in the future may take the form of an

active metabolite or something like

that,

in flood dosing,

at least that's seems pretty necessary

at this point, relatively high doses

under medical supervision cuz you can

have fatal cardiac events.

Co-administration of magnesium seems to

help, but it's dangerous stuff. People

should be careful.

You can, and there are lots of people

historically who deserve a lot of credit

for this, like Howard Lotsof,

and his wife, but

opiate addicts can go through

flood dosing of ibogaine and come out,

and they're basically given a window

with which they

won't experience withdrawal symptoms,

physical withdrawal symptoms.

And I think there probably applications

to other things with ibogaine or

pharmacological interventions like

ibogaine. And some of the craziest

stuff, honestly, related to that

molecule is

the

And I'm skeptical of this simple

description but it's a reversal in brain

age. It so it changes in the brain based

on MRIs. Nolan Williams, rest in peace,

and his lab looked at this pretty

closely pre- and post-dosing of ibogaine

for veterans with traumatic brain

injury. And some of that might be due to

something called glial derived

neurotrophic factor, right? People might

be familiar with like BDNF.

So, ibogaine is one interesting option.

Anesthesia, I've become a lot more

cautious with general anesthesia. Yeah.

Like I just had surgery yesterday and I

opted for local anesthesia, which in

this case was not a big deal cuz it was

just you can see it. Like had something

cut out of my head.

But

coming back to the

And I'm going to riff for a second here,

but the

autism spectrum disorder and ADHD

example you were unpacking where you

talked about the incentives, they might

be in perverse incentives to diagnose.

Well,

I mean,

not to quote Munger, right? But it's

like follow the money, right?

And a lot of people are put under

general who really don't need to be put

under general, but it adds a very, very,

very huge

line item to the tab. And there are

people

who go under anesthesia and wake up and

do not retain

the same ability to recall memories and

so on. Like their personalities become

in some way destabilized. And the fact

of the matter is

that a lot of anesthesia is very poorly

understood. We know it works, but it's

very poorly understood. And I don't

think

a lot of people

realize because why would they unless

they've

you know, just spending a lot of time

looking into this.

There are lots of medications that are

incredibly

well-known, commonly prescribed for

which the mechanisms of action are

really poorly understood, if they're

understood at all. You know, like we

know based on studies they appear to be

well tolerated. Like side effects

profiles include A through Z.

And it certainly seems to exert this

effect or have an impact on biomarker X.

But we don't actually [ __ ] know how

it works, you know?

And there's just a lot of stuff that

falls into that bucket. And so I am

cautious with a lot of it. But to come

back to your question, I went off on a

bit of a TED Talk. The most interesting

reboot that I've seen and I don't I

don't want to really water it down to

like the dopaminergic system cuz there's

a lot more to it. But I began I think

more so than ibogaine itself shows what

is possible. And I I don't know if

that's limited to drugs. I am very

bullish and there're going to be

fuck-ups. There're going to be some

sidebars that don't look so good. But

brain stimulation and bioelectric

medicine

broadly speaking

is one of the great next frontiers.

Certainly in treating what we might

consider psychiatric disorders.

But also for performance enhancement.

And

we're at a point kind of looking for

those external why now answers, right?

There are actually some really good

answers to why now for this as a field.

And

I think people will be experimenting a

lot with this, but without the use of

pills and potions and IVs and actually

non-invasive brain stimulation. Maybe

some invasive in the case of implants.

So that's a long answer, but yeah,

that's on what I'm thinking about and

tracking. I mean, some of this stuff

we'll see, but I think a lot of this

stuff could be outpatient procedure. You

walk in, you're in there for an hour or

two, and then you're out.

So, we'll see.