Anti-Aging Expert: Stop Touching Receipts Immediately! The Fast Way To Shrink Visceral Fat!
4773 segments
We are being bombarded with disrupting
chemicals. A lot of them, they're in art
products.
>> Okay, let's go to my kitchen. Come with
me. So, this is my fridge.
>> So, the first thing I notice is this,
cuz that's like the worst.
>> Can I get a bin bag?
>> This is made from recycled electronics.
>> What about this?
>> This is a problem also.
>> And this?
>> Ding, ding, ding. This is great.
>> I'm going to do utensils next.
>> Heating it up. The plastic is getting
into your food.
>> What about a receipt?
>> That's bad. that's covered with BPA and
study in adolescent boys showed that it
was associated with a 50% reduction in
testosterone. And then this is one that
people often miss.
>> The biomedical scientist and anti-aging
doctor Rhonda Patrick is back.
>> This time she's talking about health
optimization, maintaining peak
performance
>> and the environmental toxins disrupting
your body.
>> Dr. Rhonda Patrick, let's talk about
something that I've never heard of
before. Peak span. What the hell is peak
span? So it's essentially being within
90% of your peak function. For example,
muscle mass, bone density that kind of
peaks around 25 years old and then they
kind of steadily start to decline.
>> You're joking.
>> And the same goes for cognitive
function.
>> So I'm on the way down.
>> Yeah. And I'm definitely on the way
down. But we can do things in our life
to help maintain that peak span. Like if
you exercise 5 hours a week, do some
highintensity interval training in there
and you can reverse heart aging by 20
years. And then sleep very very
important for preventing your immune
system from aging rapidly. And then
another thing that you can do that's
really important for brain aging is this
is associated with a rapid decrease in
Alzheimer's disease risk. But what I
really want to talk about is
intermittent fasting supplements and
being sedentary.
>> So I want to talk about all of that but
we've got to talk about this in my hands
at the moment.
>> So if you have this it's going to double
your risk of early mortality.
>> Double your risk.
>> Double.
>> Okay. So talk me through this. I want as
much detail as possible.
This is super interesting to me. My team
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And some of you have told us according
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guests and conversations that you want
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Dio, and I will not let you down. Please
help us. Really appreciate it. Let's get
on with the show.
Dr. Rhonda Patrick, I am fascinated by
so many of the things that you talked
about and they're front of mind for me
at the moment because I'm a 33y old man
and I know from doing this podcast and
looking at graphs like this one, which
we'll talk about today, which I don't
think most people have ever seen in
their lives, that this is the age where
things might start changing direction
from here on over the next decade. And
there's things I can do to set myself up
now if I listen to your advice for the
remaining decades of my life to be
remarkably different. I'm playing with
this in my hands at the moment. It's for
anyone that can't see, you should
probably look at the screen right now.
It's a yellow blob of squidgy, slightly
disgusting material. What is this and
why does this matter?
>> So, this represents visceral fat.
It's something that most people haven't
heard of. Many people have heard of fat.
They know fat is bad, but they don't
realize there are different kinds of
fat.
>> There is visceral fat. And this is the
kind of fat that you can't really pinch
atapost tissue kind of fat, right? I
mean, if you opened up your body, you
could pinch it because it's deep deep
within your body. It's often referred to
as belly fat
>> and it's it's surrounding your organs
like your liver, your kidney, you know,
your intestines. This is a very deep
belly fat and it's very different from
subcutaneous fat. You can actually be
lean but have a high amount of visceral
fat. We call these metabolically
unhealthy people. So visceral fat, you
mentioned you're 33. The average 33 year
old male has how much visceral fat?
>> According to the data, it says roughly
1.2 pounds at the age of 30. And then
for a woman,.5 lb of visceral fat at the
age of 30. At 40, it's 1.7 lb for a man
and.7 for a woman. At 50, 2.2 lb for a
man, £1 for a woman. And at 60, 2.7 lb
of visceral fat and 1.54 lb for a woman,
which is the highest risk for metabolic
syndromes at that age. But I mean, all
of them are pretty scary.
>> It is. And as you notice, the trend is
as you get older, you have a higher risk
of having more of it. 70% of women over
the age of 50 have a high amount of
visceral fat. 50% of men over the age of
50 have a high amount of visceral fat.
This visceral fat, for one, it's going
to double your risk of early mortality.
Full stop. That's that's you know it's
it's going to double your risk. Double
your risk. Double double. Visceral fat
is as I mentioned different from the
other kind of fat. The subcutaneous kind
of fat the atapost tissue kind of fat
>> in several ways. One is that it is
metabolically active. It is secretreting
inflammatory cytoines. These are, you
know, molecules that are signaling to
the immune system, but they're also
involved with damaging our cells. And
for this reason, people with a high
amount of visceral fat are 44% more
likely to get metastatic cancer. That's
cancer that's going to metastasize. Very
dangerous types of cancer. They're also
more likely, you mentioned metabolic
syndrome. This is a big big thing with
visceral fat. This type of fat is
constantly
breaking down triglycerides into free
fatty acids. It's constantly doing it.
>> What's triglycerides?
>> Triglycerides are how your body is able
to store fatty acids and fat and use
them for later, you know, energy, right?
So, they're constantly breaking them
down and using them. They're using these
these fatty acids. But typically what
happens in your body when you eat a
meal, you have your glucose levels go
up, right? Your blood sugar elevates,
your glucose levels go up and that
signals to the pancreas in your body to
make insulin. Insulin is this hormone
that plays a role in many things. One of
it is to tell different parts of the
body to take gluc glucose up like your
liver, your muscle, your atapost tissue.
Well, the problem is is this visceral
fat is constantly making those free
fatty acids. And so those fatty acids,
it doesn't it doesn't respond this this
we call it it's not really an organ, but
this type of fat doesn't respond to
insulin. So whereas the subcutaneous fat
will stop breaking down fat and using
fat as energy. It says, "Okay, look, I
have energy here. I got to do something
with this energy. Let me let me store it
for later use." Right? Well, that that
doesn't happen with visceral fat. What
happens is it just keeps going, keeps
going, keeps going. What happens is when
your visceral fat is metabolically
active like that, it is basically making
it where insulin can't work its job. And
so what happens is that glucose can't go
into your liver. It stays in your blood
system.
>> And you really want it to be stored in
your liver, right?
>> You want it to be stored in your liver
as glycogen to be used as energy when
you're fasting or when you're, you know,
physically active or when whenever you
need it, right? Also in your muscle.
same thing, stored as glycogen or stored
in your atapost tissue. Um, and so and
so none of that happens because insulin,
it's not able to to basically act on
your your your organs. It's there's no
signal. So no, nobody's getting the
phone call, hey, time to take the
glucose up. It's not happening, right?
So the glucose sits around. So what
happens is your body freaks out because
it's not good to have glucose sitting
around in your bloodstream for a while.
It causes a lot of damage, right? Mhm.
>> And so what happens is your body makes
even more insulin to try to
overcompensate. Your body goes, "Oh,
maybe that wasn't enough insulin
because, you know, the glucose isn't
coming in to the organs like the liver
like it's supposed to. So, let me put
some more out."
>> And for anyone that doesn't know,
insulin is kind of like the taxi driver
that goes and picks up the glucose and
takes it home.
>> Exactly. It's taking it home. It's
taking it back to the liver. And so what
happens when you make more insulin,
you're overcompensating in such a way
that now glucose really does get taken
up into these other organs like the
liver. And it so much so that it causes
your blood glucose levels to go down and
and you're crashing. And all of a
sudden, this is responsible for that.
You know, people that eat a meal and
they're kind of insulin resistant. They
eat a meal and then all of a sudden
they're crashing an hour later. We're
like, why am I why do I have no energy?
Why am I hungry? Right? Because when
you're after you crash, your blood
glucose levels go down. That's what I
mean by crashing. Um really f far down.
Not not normal levels, but like below
that. And so then your body tries to
overcompensate by going, "Oh, I'm
hungry. I need to eat." And so you start
to have these cravings for like energy
dense foods. And that's part of this
cycle of the beginnings of insulin
resistance. And so when I'm talking
about here with visceral fat, it causes
insulin resistance. And that's
essentially the take-home here by by
it's constantly metabolizing fatty
acids, it's it's stopping that taxi car
from going and getting the glucose. It's
it's not happening. It's not responding.
You're not picking up the driver, right?
And so you become insulin resistant. And
that has a lot of problems. One, it's
going to affect your immediate energy
levels. It's going to affect the way
you're feeling. And two, it's going to
make you more likely to become type two
diabetic because eventually your body
will won't be able to produce enough
insulin to bring the glucose in. And so
then you become type 2 diabetic. So that
is a big consequence of having this
visceral fat in addition to those
inflammatory molecules that are being
generated from this fat. It's just so
metabolically active. And that
inflammation that you're generating not
only does things like raise your cancer
risk by 44%. It also makes you tired. It
gives you brain fog, lethargy. When your
immune system is being activated by this
inflammation,
you're taking energy away from your
brain. It c it's a lot of energy to
activate your immune system. And so,
yeah. So, that energy is now going to
the wrong place. It's not going to your
brain.
>> So, you can feel you won't feel
cognitively as sharp and
>> absolutely won't just think about when
you're when you're when you have an
infection. Your immune system is very
active. You're fighting off a pathogen,
right? Do you feel like you're tired or
do you feel like you're cognitive
cognitively at your peak?
>> Uh yeah, I'm like I'm I'm out of out of
action for several days usually,
>> right? You're tired and your brain isn't
working. And part of that reason is
because your activation of your immune
system is sucking energy away from your
brain. And the other reason is because
the inflammation being generated gets
into the brain and disrupts
neurotransmitters and things like that.
So you're it's like a double whammy.
You're not your your brain isn't working
working properly. And so there's a lot
of people walking around constantly
feeling tired, feeling lethargic,
feeling brain fog, and they might have a
high amount of visceral fat and not even
know it. So typically,
>> looking at the data, I mean, most people
have too much visceral fat.
>> Most people do have too much visceral
fat. And typically a really high amount
is I would say a proxy for it would be
measuring your waist circumference. So,
like if women have a waist circumference
of 35 in or greater, that is a sign of
too much visceral fat. If men have a
waist circumference of 40 in or more,
that is a sign of too much visceral fat.
Ideally, you would go and get what's
called a DEXA scan. Now, this is not
something that's routinely done, and it
doesn't necessarily have to be done
unless you're that person that really
likes to go the extra mile and directly
measure things. That would be another
way to do it. You really want to have
below 300, you know, grams of visceral
fat. ideally closer to zero the better.
>> Me and my friend went and got a DEXA
scan done and the remarkable thing is I
weigh a lot more than him and I'm much
bigger than him. He's skinny but after
the DEXA scan they said that he had too
much visceral fat which I I thought vis
I thought you must be like big or obese
to have visceral fat but he's a skinny
guy and the DEXA scan said too much
visceral fat.
>> Yes, that's the thing. You know, I was
involved in clinical research for many
years when I was doing my post-graduate
training. And we were looking at
populations of people that were
metabolically unhealthy or maybe
overweight, obese in some cases, and you
would have someone come in that they
looked skinny, they looked like they
were metabolically healthy because they
weren't overweight. And yet all of their
biomarker data was showing the opposite.
Like they looked on paper, if you would
have shown me their metabolic data, I
would go, "Oh, this is an overweight
obese person." So these are these are
lean but metabolically unhealthy people
and a large percentage of that has to do
with an increase in visceral fat. You
won't even necessarily know that you're
getting higher amounts of v visceral
fat. It's not necessarily going to be
reflected on the scale. You know, you
mentioned maybe a pound, maybe a little
bit more. That's like daily fluctuation
in some cases, right? Like I mean I
don't know about you, but like I I can
fluctuate a pound from day to day for
sure. If you're talking about 500 grams
or less, that's not going to be, you
know, reflected on a scale either. You
might be going, well, what why visceral
fat? What's causing visceral fat? You
know, I mentioned age, that's a big one.
Hormones is a big one. Women are very
susceptible as they go through
pmenopause and menopause because
estrogen actually tells helps tell the
body how to store energy and it tells it
to store energy and fat in atapost
tissue, not viscerally. So when your
estrogen starts to go down during par p
parmenopause and then menopause, women
really start to gain a lot of vis this
belly fat. They gain a lot of the
visceral fat. Testosterone also it
doesn't tell the body how to store the
fat so much. It helps you burn visceral
fat. So men are a little bit more
protected when they're younger as well,
but as they age, of course, testosterone
goes down as well, and that affects the
visceral fat. But mostly, it's our diet
and our lifestyle that's really
affecting visceral fat. It's kind of
mind-blowing how quickly you can gain
visceral fat. Like there was sleep is a
big one. When you're when you miss
sleep, that is something that can really
you can start to store you can start to
gain visceral fat very quickly. Um there
was a study in healthy young men. These
men were sleep restricted. Typically
when sleep restriction studies are done,
you're you're looking at four hours of
sleep per night. So pretty severe. Not
out of the ordinary. I did many of those
college graduate school deadlines.
Definitely as a new parent, I mean it's
unfortunately drags on for months. So
these men were only sleeping four hours
a night for two weeks. Okay, these are
healthy young men, college age students.
Okay, young. They gained 11% visceral
fat after that two weeks, but not a
pound on the scale, but they had 11%
higher visceral fat after just, you
know, two weeks of not getting enough
sleep.
>> And they weighed the same
>> pretty much. So, it was the composition
of their body that's shifting.
>> Yes. Also, the visceral fat, like like I
said, you're not gaining pounds and
pounds and pounds of it necessarily. You
know, you're gaining grams and grams,
but like it's happening and and any
amount that you're starting to gain is
unhealthy, right? It's going to start
causing insulin resistance. It's going
to start, you know, causing fatty liver.
That's another thing. It does it because
it's around the liver. It basically the
liver doesn't know what to do with all
the fat. So, it starts to make and store
it around the fat. And so you start to
get this non-alcoholic fatty liver which
is happening now in like young people.
So sleep is one another major major I
would say lever for gaining visceral fat
is your diet quality and quantity. So if
you start to be in a caloric excess
constantly you can start to gain
visceral fat and that's also been shown
in studies. So, there was a recent study
that again was in healthy young men
given about 1,200 extra calories a day
and it was mostly from ultrarocessed
foods, right? I mean, they're 1,200
calories, so like Big Mac and a Coke,
Big Mac and fries, whatever, you know?
So, you're you're talking about almost
like an extra meal a day and from
processed foods, ultrarocessed foods.
For 5 days, they were given, you know,
this extra caloric intake. After that
five days, they started to gain visceral
fat. They started to have signs of fatty
liver after five days. And their brains
became insulin resistant. And this is
important. Yes. You
>> How many calories were they having in
excess?
>> 1,200 to,500.
>> In excess.
>> More than what they were usually going
to eat. Yes. Okay.
>> Yes. So, you know, it's a lot of people
are eating caloric excess, you know,
daily. They're not they're not
exercising and there's no energy
expenditure and they're eating more and
so they're in in you know 1,200. Now
this is the extreme end right I'm giving
you an extreme end because that's what
they do usually in in studies like this
because they want to get a significant
result but after 5 days they they were
gaining visceral fat their brains became
insulin resistant. So insulin is also
very important for the brain. the brain
is telling the body how to store the fat
and how to store energy. And when the
and when insulin is not able to to get
into the brain and have its action, then
you start to not have the brain tell the
body how to store this energy and it
ends up storing it viscerally. It's like
this default.
>> Do you know putting those two things
together, the thing I've noticed that
impacts my performance the most as it
relates to articulation, cognitive
performance, my ability to think is
those two things coming together. You
talked about sleep and diet. It's when I
h I eat late
>> close. It's when I eat close to sleep.
If I do that a couple of nights in a
row, I feel like my brain no longer
works.
>> Yes. Yeah. You know, obviously we all
have to like live our lives and there's
social things and it's fun to go out and
have a dinner with your friends or an
event, right? But it's not a good idea
to eat a meal, a big meal three hours
before, fewer than three hours before
bed. So, you want to stop eating 3 hours
before bed. And three is really the
magic number in multiple studies because
when you eat a meal, it is activating
your sympathetic nervous system, right?
That's the fight orflight response.
That's not what you want active when
you're about to go to bed. When you're
activating the sympathetic nervous
system right before you're going to bed,
let's say you eat a meal within an hour
of bedtime, you're digesting all that.
It's your sympathetic nervous system is
active. And even if you're sleeping,
it's not good sleep. It's fragmented
sleep. And so it's disrupted sleep
because you you need to be in that
parasympathetic
part of, you know, the nervous system.
That dominance needs to be
parasympathetic, which is the rest
restore. It's called rest and digest.
But I don't like digest because actually
digesting is what activates the
sympathetic nervous system. So it's like
the recovery, right?
>> So should I stay up then for three
hours? If I if I eat at midnight,
>> should I stay up till 3:00 a.m.?
>> No. No. You should just go to bed, but
don't do it on a daily basis, right? I
mean, the the key is the habit, you
know, the habit. And so, if you need to
eat something before bed, you should do
something that's light. Maybe a protein
shake with some almond milk, you know,
something that's not super heavy.
>> I've heard you talk about fiber.
>> Resistant starch does, interestingly,
seem to help improve sleep. And so, you
know, maybe some rice or a potato,
>> a little bit of rice or a potato,
>> some fries or something.
>> Maybe not a fried potato, baked baked
potato and then cool it because then
it's resistant starch, right? Because
then it's good for your your gut
microbiome.
>> Why?
>> It changes the composition of the fiber
>> and and you can cook it, let it cool,
and then heat it again if you like to
eat it heated as long as it went through
a cooling part.
>> Wow.
>> And then you can eat it. But that's
resistant starch. Resistant starch is
also in green bananas. very beneficial
for the gut and also for interestingly
for improving sleep. So things that are
really moving the needle to to make you
gain visceral fat or being in basically
being in a caloric excess especially
from refined highfat high sugar foods.
And then not getting enough sleep, move
the needle. Chronic stress is an
amplifier of it. So if you're constantly
having cortisol that's kind of stopping
the body from storing energy right the
right way and it's going viscerally as
well. I would say that amplifies
especially if it's like in the context
of being in a caloric excess and not
exercising. Alcohol is another one. If
you drink if you're excessively
consuming alcohol you're going to store
a lot of the energy that you're also
consuming is going to be stored
visceral. I mean you've seen the beer
belly right? I mean that's like a thing.
It's visceral fat. It's it's not beer.
It's visceral fat. So alcohol is another
one. In terms of losing visceral fat, I
mean the good news is is that you can
lose it quite easily and quite rapidly.
I
>> was going to say parents have a hard
time because you're naming those things
about like sleep and stress and and I
was thinking gosh parents have like a
have it coming from them from all sides.
>> They do. Um the but see this is where
the good news comes in because you know
part of the reason why sleep is causing
you to gain more visceral sleep loss is
causing you to gain visceral fat is
because it's causing your body to become
insulin resistant. It's like this
vicious cycle. Visceral fat causes
insulin resistance. Insulin resistance
causes more visceral fat. Right? And
becomes this and that's why once you get
into that cycle it just spirals out of
control, right? And you start to gain
more and more and more.
>> Sorry. Insulin resistance. What is that?
That is when your body no longer
produces insulin or
>> No, no. Insulin resistance is when your
body is no longer responding to insulin.
So, it's like it's like you're waiting
for the phone to ring and it's ringing,
but you can't hear it, right? Like you
you're not getting the signal and so
your your cells are not responding to
the insulin that's made. Insulin is
really helping your body bring move the
glucose out, right? move it move it out
of your bloodstream where it can cause a
lot of damage if it sits around
>> and if you put too much pressure
pressure on the insulin system then it
kind of shuts down
>> eventually shuts down
>> and the thing that puts too much
pressure is consuming too much glucose
or too much activity
>> too much glucose refined glucose can do
that visceral fat is one of the I would
say bigger causes of insulin it's
actually one of the major major causes
of insulin resistance because if you are
physically active and eating a lot of
glucose, that glucose is going to your
muscles. Physical activity makes your
muscles very responsive to glucose
without needing insulin. Your the
transporters that transport glucose are
super super responsive when you
exercise. That's why physical activity
and this is what I was getting at with
parents is so important. The visceral
fat is the really big like concern with
insulin resistance. This is and this is
the thing that again it's like people
don't even know about it. A lot of
people are thinking about glucose and
oh, I got to watch my glucose. And
that's all fine. I mean, yes, to some
degree that's also playing a role, but
it's it's it's the visceral fat that's
the real underlying problem that's
that's causing you to become insulin
resistant. You mentioned parents have it
like bad because they're stressed out
and they don't get sleep. I was wearing
a continuous glucose monitor when I
became a new mother. I was appalled by
my fasting blood glucose and by my
postprandial blood glucose levels. Never
>> postrenal. Postprandial means after a
meal. Okay?
>> So your levels go obviously much higher
after you eat a meal versus in the
morning when you haven't had anything to
eat.
>> And my levels were were so high. It was
pre-diabetic
>> and and I was just I couldn't believe
it. And it's not like I'm eating, you
know, drinking Cokes and eating
terrible, right? But there was a period
of time when I'm not as physically
active, particularly in the first couple
of months. It's really, you know, that's
the time when you're kind of just in
this cave. I immediately was looking
into the scientific literature and found
that high-intensity interval training
and exercise can help almost negate most
of the those poor effects of causing
insulin resistance and causing your
glucose regulation to not be normal.
That's the good news for parents is that
you should prioritize new parents should
prioritize exercise and exercise does
cause you to lose visceral fat. It's not
just any type of exercise really has to
be aerobic and the more vigorous the
better. So for people that don't know
what that means, aerobic and vigorous.
>> Yeah. So what I mean is resistance
training and lifting weights don't
really move the needle in terms of
helping you lose visceral fat. It does
help you improve your metabolism. It
does help with like glucose, you know,
sensitivity and all that like because
your muscles are going to be more
sensitive to take the glucose in. But if
you want to lose visceral fat, you're
going to have to do running, jogging,
cycling, swimming. You want to like get
your heart rate up a little more.
>> Why? It's energy expenditure. It plays a
role in getting you to that caloric more
caloric deficit and that's better. So
that's one way. And the other thing is
weight any any weight loss program. So
intermittent fasting, caloric
restriction, you know, even GLP-1
receptor agonist and all the classes of
GLP1, anything that is going to make you
lose weight, lose fat, visceral fat's
one of the first to go. And in fact,
people on on these these weight loss
programs or even on exercise training
program, visceral fat's the first fat to
go and and so you can lose it quite
quite quickly.
>> So on this point of fasting, are you a
fan of fasting to combat visceral fat?
And also, could you give me your
thoughts on being in a ketogenic state
as it relates to visceral fat? Yeah,
people when they think about
intermittent fasting, they kind of think
about,
you know, one thing and they think about
weight loss, right? But there's a lot
going on here. And I like I like that
you mentioned being in a ketogenic state
because there's also a metabolic switch
that happens. This metabolic switch from
burning carbohydrates and glucose to
burning fatty acids and getting in
ketosis, right? That's a metabolic
switch. And it's very important. There
are two different things happening here.
But intermittent fasting is essentially
a good tool that people can use to
reduce their calorie intake without
having to count their calories. That's
why I like it. You can you can lose
weight by counting your calories and
reducing your calorie intake. I
personally think that's a lot of work.
Some people love doing it and that's
great. I think whatever works for a
person. But the way in which
intermittent fasting helps people lose
visceral fat is by reducing calorie
intake. That's what I'm getting at. It's
like a tool that some people like to use
because I like it for one because I can
not think I just I'll skip one meal
making sure I get enough nutrients in
the the meals that I eat and protein in
the meals I eat. But I'll skip a meal
and it gets me in a caloric deficit
without having to think about and count
everything. So it's easier on me
>> to fast
>> to fast versus counting calories.
>> And how how do you do that? So, I like
to fast in the morning. And the reason I
like to fast in the morning is for the
exact reason you mentioned, and that is
the ketosis, which I like to call the
metabolic switch. You're not eating
while you're sleeping, obviously. So, if
you're sleeping for 8, if you're in bed
for 9 hours, 10 hours, you're not eating
during that time. And it takes about 10
to 12 hours for your liver to deplete
glycogen. glucose that's been taken up
by the liver is stored as glycogen so
that you can then use it for energy
later if you don't have energy coming
in. Right.
>> So the glycogen is like the the petrol
station.
>> Yes.
>> So it runs out of petrol.
>> That's right. And and so um it takes
>> it switches to diesel.
>> And it switches to diesel. And so after
that switch, that metabolic switch when
you deplete that glycogen while you're
sleeping or while you're not, you know,
not eating after about 12 hours. And by
the way, this is all relative because it
depends on the kind of foods you eat and
how physically active you are. So, if
you eat a lot of high carbohydrate,
refined sugar stuff, you might take even
longer to deplete your glycogen because
you're you're putting a lot of input in
there. You keep filling up the the fuel
tank, right?
>> But if you're eating things that are
more low carb, you might deplete your
glycogen sooner. So, when you deplete
your glycogen, you get into this
metabolic switch because your body still
needs energy, but there's no nothing, no
glucose around, right? So, you start to
switch to, you know, your fatty acids
are mobilized. They come out of your
atapost tissue. This is why people lose
fat. They come out of the visceral fat.
You you start to use those fatty acids
and burn them as energy. And as a
product of that energy, you're making
ketones, ketosis. And the reason I like
to do this in the morning is because
then I can really get into that ketoic
state where if I'm fasting, I do it
typically I fast for about 16 hours a
day and then I eat my meals within eight
hours a day. Typically, that's my what I
do. The reason I like to be in that
metabolic switch state is many reasons
actually. One, the ketones themselves
are providing my brain with energy, very
e easily utilizable energy, but they're
also acting as a signaling molecule to
my brain going, "Hey, this is a
stressful time. There's no food. You
better be cognitively sharp. You got to
find that food. You got to like know
what you're doing, right? It's an
evolutionary adaptation." You know,
humans for thousands of years were going
through this metabolic switch because we
didn't have Instacart. We didn't have
Postmates. We didn't have all Uber Eats,
right? We had to find our food. We had
to hunt our food. And we always didn't
always do that, right? And so when I get
into that metabolic switch state, I feel
it. I feel more cognitively sharp. And I
feel less anxious, which is part of it
because those ketones also help increase
something called GABA. That's an
inhibitory neurotransmitter. It's
essentially, you can just think of it as
like it helps you feel calmer. When I
feel calmer, I'm more cognitively
focused because it's like the background
anxiety is down, right? It it's like you
can focus. And so, I love being in that
state in the morning because that's when
I get my work done. I also like to be in
that metabolic switch state. And this is
why I like fasting in addition to, you
know, the calorie, the fewer calories
I'm consuming, right? Your body has to
be in that fasted state to repair. If
you're constantly in a fed state, fed
states are important for anabolic
growth. We need it to grow, right? But
the repair state is also very important
because with the growth comes damage.
Damage comes along with that and you
want to repair that damage because
damage will accelerate aging. And so I
like to be and give my body enough time.
I don't want to just wake up and eat
where it's like, oh, I've only barely
depleted my liver glycogen. I'm not even
in that repair state very long, right? I
want to extend it a little bit. And so I
like to have that repair process active
and that it is active during it's
fasting activates it but also you have
some amount of active repair going on
even when you're in a fed state. It's
just heightened when you're fasted. So
those are the reasons I like to be I
like intermittent fasting. I feel good
when I do it. I also do a lot of
training, not all of it. I do a lot of
training fasted. Cardiovascular aerobic
endurance exercise. So running, biking,
that stuff I like to do fasted. I'm not
going for a 10-mi run. I'm going for a
three- mile run, right? I mean, this is
So, if I was going for a 10 mile run, I
wouldn't be fasted. I would need some
fuel. But there are studies, me,
multiple studies showing that if you do
aerobic endurance training, this kind of
running, cycling, swimming type of
training, you actually have better
adaptations if you're fasted versus fed.
>> What does that mean? So much of the
benefit from exercise, right? Aerobic
exercise when you're breathing in,
you're you're you're you're right,
you're working hard is from the working
hard, but your body responds to that,
right? Because the working hard is
causing inflammation. It's causing
oxidative damage. And your body is
responding to that by going, "Oh, we got
to get better at this stuff." So, you
have anti-inflammatory pathways
activated. You have antioxidant pathways
activated. Your body needs to burn fat.
You need fuel. And so if you're fasted,
you get better at burning the fat and
oxidizing the fat and you continue to do
that throughout the day better as well.
So you have what are called
mitochondrial adaptations that are
better. You make more mitochondria.
Mitochondria are very important little
tiny organels inside of most of our
cells that make energy and they, you
know, they're very important for
everything. I mean, they're running our
brains right now so we can talk, our
heart, you know, so we can breathe, our
lungs, everything, right? And so
exercise does make you increase the
amount of those new mitochondria that
you make that are young and healthy.
>> If you're fasted
>> both, even if you're not, but if you're
fasted, it's even better.
>> This has been a big debate around
whether this applies to both men and
women.
>> Should both men and women exercise
fasted?
>> This is my read of the literature and my
thoughts on this from also having
experts that have studied male versus
female responses to exercise. First and
foremost, how do you feel when you
exercise fasted? If you feel terrible,
that's a sign. I think listening to your
body is the most important thing that
you can do. There are times when I have
to eat before I exercise and I listen to
my body. I that's it. I'm I'm going to
eat. When it comes to women versus men
and doing exercise fasted, it also
depends on are you again, are you doing
a 30 minute run? Are you doing a 2hour
run? If you're doing a 2-hour run, you
need to fuel. That's a lot. That's a big
stress. When it comes to a 30-minute
run, you don't really necessarily need
to. Now, the problem with women is that
they're often if you're in too much of a
caloric deficit and you don't eat enough
food within, you know, like afterwards,
you're not refueling enough and you're
doing very very long high volume types
of exercise, then you can basically
disrupt your, you know, some of your
hormones, your your follicle stimulating
hormone, luteinizing hormone. These
things will make you become amenoretic.
So you basically stop ovulating and you
stop getting your menstrual period.
>> And what's the evolutionary reason for
that? What's going on?
>> Because your body's like there's not
enough food and energy around to sustain
a ba, you know, a growing fetus like
they're growing shutting down.
>> So it's so it's basically like, hey,
we're not going to allow you to have a
baby basically. So you stop you stop
ovulating, right? So you can't you're
not making you're not making those eggs.
Is this often the case with women who
exercise a lot and no longer have their
menstrual cycle?
>> First of all, this is not a common
thing. This is like this is something
that happens in, you know, like
athletes, elite athlete, women that are
not eating enough food. Like I I did
this to myself when I was in my early
20s and I was running I was racing
marathons and I was running 10 miles a
day, you know, eight to 10 miles a day,
five days a week and then I was eating
carrots and hummus and you know, I just
I wasn't fueling myself and I did I did
this to myself, too. So, how do you feel
if you train fasted? Do you feel
terrible? Don't do it. If you want to
train somewhat fasted, go for the
protein, you know, protein shake with a
little bit of almond milk or something
like that where you're not eating a full
meal, but you're getting something. So,
I do a lot of my training fasted and
that has helped me. You know, I'm 47
years old and penmenopause.
>> You're in phenomenal shape.
>> Thank you. Thank you. Um, but I did
notice, of course, as as I started to
reach that pmenopause part of my life
that I had to be a little bit more
aggressive and put a little bit more
effort in to not get this fat right here
on my belly cuz it started coming up and
I didn't want it. I didn't it wasn't it
wasn't an option for me. Speaking of uh
studies done for women, you I've heard
you talk in the past about the Swan
study, which kind of relates to what you
just said there. Um when relating to
women in visceral fat, and they found
that women experience an accelerated
increase in visceral fat starting 2
years before their final menstrual
period.
>> Yeah. Because that's when their estrogen
is about it's just it's plummeting,
right? You're just going off a cliff
because you're you're about to go into
menopause.
>> Again, what age would that be? Average
age of menopause is between 50 about 50
52 for women. A lot of that there's a
lot of things that can affect your
reproductive lifespan, your ovarian
aging I guess we can call it. And
unfortunately, one of them is when you
the age you were when you got your
menstrual period. So the younger you
were, the younger you're going to be
when you experienced menopause. So also
when your mother experienced menopause
is very very indicative of when you're
going to experience it. But lifestyle
and diet play a role too. Obesity
accelerates ovarian aging. So you're
more likely to go into menopause earlier
with obesity. Also these chemicals that
we're exposed to and we can talk about
those as well. A lot of these endocrine
disrupting chemicals affect the age of
menopause as well and and accelerate
that. So some in some cases women go
into menopause two years earlier than
they would have otherwise.
>> And you're so you're 47
>> Mhm. and a half
>> and a half. And the data that I'm
looking at here says when we think about
permenopause, it usually starts in
mid-40s, which is the age range you're
in. This is where the 8 to 10% annual
visceral fat increase begins.
>> It is. And and I
>> Yeah. I can tell you from people in my
life that I've seen going through this,
it's pretty sudden that you'll see
someone in your life that's a woman
that's going through Mary Pen Perry
menopause and maybe hasn't had any other
symptoms yet, so they haven't really see
any treatment. Now, you can you can try
to do some hormone replacement therapy
as well to help with that, but they
start to gain visceral fat and it shows
up around the belly quite rapidly. And I
noticed this in myself. It almost feels
overnight. Seriously, this is the only
symptom that I noticed in myself where
it was like all of a sudden my belly was
like growing and um you know, not super
super large, but enough where I was like
there's something wrong. It's not even
necessarily reflected if you get hormone
tests cuz mine all seemed normal. The
thing is is that the estrogen when it
drops that estrogen is so important for
telling your body to store energy
differently, not around the organs, but
to make it around, you know, other parts
of your body like your your thighs and
your butt, right? Like your atapost
tissue. And so when that estrogen goes
down and declines, it's like boom, it
starts to go right to the belly. So that
is why for me intermittent fasting has
been really important. Like with any
weight loss or calorie restriction
protocol, you do need to make sure
you're getting enough protein because
that's important for muscle, right?
Muscle growth and preventing atrophy of
your muscle. And you need to also do
resistance training. That also is a very
important signal for muscle. Because the
problem is some people calorie restrict
and eat fewer meals and then they're not
getting enough protein and they're not
training and they start to lose muscle
in addition to fat and you don't want to
do that. You want to kind of just lose
the visceral fat and keep the muscle
ideally keep gaining muscle.
>> And for men, I was reading that
testosterone and growth hormone
typically peak in their late 20s. So I
guess mine's peaked already. Um and
starting at age 30, testosterone drops
roughly 1% a year. So between the age of
25 and 65, men typically see a 200%
increase in their visceral fat even if
their total weight stays the same. So
is that linked into testosterone
decline? Is that what's going on there?
What's causing it?
>> Yeah, I mean it's it's testosterone does
you burn even if you're gaining visceral
fat, it helps you burn it. It's it's
also why some women that are in
pmenopause want to do testosterone
because it helps them burn the visceral
fat. M um so it is it is linked to
testosterone decline as well but also as
men are aging their they become more
sedentary they send they tend to eat a
little bit they're consuming more
calorie like all these things are
handinand so it's like a it's not just
like a one punch right it's like
multiple angles are kind of all
compounding and coming together whereas
you could get away with it a little bit
easier when you're younger because the
testosterone was helping you burn it
more
>> when you're declining it doesn't it
doesn't work that same way so even
though you're gaining it you're not
burning it as quickly so you start to
have a net gain in it. Uh if that makes
sense.
>> So going back up to the top then we were
talking about things you can do to lower
your visceral fat and we talked a little
bit about exercise, sleep, diet. Is
there anything else in that category?
>> Yeah, I think those are the main ones.
Obviously avoiding excess alcohol
consumption. Yeah.
>> And also
>> stress. Stress.
>> Yeah. Yeah.
>> The stress like you know trying to to
relaxation techniques buffer that
stress. That's a big one. It's an
amplifier.
>> Yeah. People don't talk enough about
visceral fat, you know, they look at
other markers.
>> No. Well, most people just want to lose
weight and look good.
>> Yeah.
>> Or Yeah. They look at, you know, HBA1C,
your long-term glucose, or they're
looking at lipids, and visceral fat is
just it's it's insidious, right? It just
starts increasing, increasing,
increasing. You can't see it. You can't
see until all of a sudden belly, right?
I mean, it's it's it's bad. And it
affects the way you feel daily. On this
point of testosterone, why is it the
case that testosterone seems to be
dropping amongst men? I think it said
something like I wrote it down. Yeah,
testosterone levels in men have dropped
by up to 20% over the last two decades.
>> Um, which is quite terrifying.
>> It is. So, look, there's a lot of
factors that can affect testosterone. I
mentioned dietary factors, refined
sugar, sleep is a big one. people aren't
getting enough sleep, lack of sleep
drops testosterone, micronutrients, not
getting enough zinc, for example, zinc's
very important for testosterone
synthesis and magnesium. Like there's a
there's there's important nutrient
components, but I think the big player
here is actually environmental. I think
that
we are being bombarded with what are
called endocrine disrupting chemicals.
These are man-made chemicals. A lot of
them are part of plastic. They're made
to help plastic be more durable or more
robust or they're found or they're water
resistant. So there's probably three
main endocrine disrupting chemicals that
are found in our environment mainly
because they're in plastic or they're in
they're also in things that are water
resistant, oil resistant, fire
resistant, flame retardant. BPA
bisphenol AA is one. Another one is
phalates. PH phalates. And the last one
would be PAS. These are the forever
chemicals. These are the three main I
would say players in terms of disrupting
endocrine function. Endocrine being
hormones. Sex hormones like
testosterone, estrogen, but also thyroid
hormone. Very important for regulating
our metabolism for example.
>> Are they really causing a problem?
>> Absolutely.
>> Really? Like
>> absolutely. cuz I'm looking at the
picture you have there of Pa Pas
>> PAS
>> PAS and it's got like a coat and shoes
on there. You're telling me my the
clothes that I wear are having an impact
on my hormones.
>> They can, but I think it's it's it's
less of a direct effect and more
downstream. So the the the PAS chemicals
or the forever chemicals, they're used
in things to make them oil resistant,
stain resistant, water resistant. So the
teflon pans would be the biggest
example. You remember those non-stick
pans? They have teflon that has PAS on
it.
>> We're going to go into my kitchen in a
second. So, I'll take all of the viewers
that are watching now into my kitchen.
We'll have a stroller around my kitchen.
You let me know if there's some things.
>> Oh gosh, I hope you don't have Teflon.
But, I mean, my mom used it when I was,
you know, growing up. I remember the
non-stick pans that stuff is coming off
into your food and so you're eating the
these PAS.
>> How do we know that they're dangerous?
>> Okay. Well, I'll tell you how we know.
like let's let's start with so the PAS
chemicals are ones that are really
they're more affecting the thyroid and
they're affecting I would say ovarian
aging they seem to target the ovaries
and accelerate the age that you're going
to get menopause so you're going to get
it around two one to two years earlier
if you have a high amount of these
forever chemicals but there's been
studies a lot of studies looking at
let's start with BPA okay bispenol A
that's a big one because you see a lot
of marketing around BPA free. This
plastic water bottle is BPA free. Well,
it's BPA free, but it has another
chemical called BPS, which is very
similar, if not worse, than BPA. So, BPA
is something that's found in a lot of
water bottles. It's in those plastic
water bottles. It lines the cups of uh
paper cups, like these to-go coffee cups
that you're getting at your favorite,
you know, coffee place. Plastic is
lining them. Yes, plastic lines them
because it's protecting it from the
liquid, right? BPA has been linked to
many different diseases, but really
really it's an endocrine disruptor. So
what it does is a couple of things. One,
BPA acts as an estrogen mimemetic. So it
kind of mimics estrogen and it binds to
the receptors that estrogen do to do its
function. And so it sometimes binds to
estrogen and either makes it seem like
there's estrogen around or it blocks
estrogen from working. So it's it it
depends on the dose and the
concentration. So it can do both, but it
also binds to androgen receptors that
interact with testosterone, right? And
so there have been studies that have
found that men that have high amounts of
BPA also have low amounts of
testosterone. That there was also a
study done in teens. This is when you
know your sexual development is
happening, right? Testosterone is very
important during this part of of your
life during puberty. Teens, adoles, ad
adolescent boys that had the highest
amount of BPA
had 50% lower testosterone than men than
the boys, sorry, that had the lowest
amount of BPA. The biggest one that's
affecting testosterone is the phalates.
These phalates, they are present in a
lot of PVC piping. They're present in a
lot of our food packaging. all those
like thin art or you go to the you know
to the grocery store and you get a filet
manon steak and it's wrapped in plastic
poultry all that plastic wrapping and
all the foods that we're eating has
phalates in them that make it more
flexible and stuff and it's also found
in our hair products our cosmetic
products our creams and it's also very
lipid
soluble it likes fat it is drawn to fat
so when you have plastic around fat like
cheese you know things like fat meat.
It's getting into that meat. It's
getting into that cheese, the phalates.
These disrupt our hormones in ways
similar to BPA. So, they're binding to
the androgen receptor, but they're also
going into the testes and disrupting the
synthesis of testosterone. So, there was
a study in men that had the highest
phalate levels, those men had 20% lower
testosterone compared to men with higher
levels. And
>> and this is Yeah. And this is like it's
affecting not only just the
testosterone, but it's affecting sperm
quality. So the shape of the sperm
wasn't good. It's affecting the number.
So sperm count is down if they're higher
BPA or higher phalates. And also um
motility, the the ability to swim.
Pregnant women that get exposed to high
levels of phalates and if they have if
they're carrying a a male fetus, right,
they they're having a boy. What's been
shown is it's also affecting sexual
development. So these boys, they're
getting something called hypospadia.
That's where like this the slit on the
ur on the um on the penis is like moved
backwards kind of closer to like what a
a woman would have. And they're getting
undescended testicles. So one of their
testicles is not descending. And that's
associated with you know infertility,
cancer, testicular cancer being the big
one. This is happening at a alarming
rate. like something like 20% of boys
now have an undescented testicle. I
mean, it's crazy
>> because their mother had high phalates.
>> Well, it's this is definitely something
that is known in our environment to
cause that. I don't know if that's the
only cause, but it in my opinion is a
very very concerning cause that nobody
is talking about and that should be
addressed. And it's everywhere. We have
these in all of our all of our plastic
wrappers that we everything that we're
eating. you know, you you even getting
your meat, you're you think it's well,
it's meat. It's, you know, but it's
wrapped in plastic and that phalates are
getting into the food. So, they're
getting into our bodies and they're
disrupting hormones. They're disrupting
sexual development. They're disrupting
our ovaries, estrogen, you know, ovarian
aging, age of menopause. They're
disrupting thyroids, the thyroid
hormones. I mean, there's there's even
studies now with women, pregnant women
that have high levels of BPA.
they have they're six times more likely
to have a child with autism spectrum
disorder compared to women with low
levels of BPA. Again, BPA is disrupting
the estrogen and androgen receptor. And
this is very important because
the androgen you you want to have it's
it's disrupting aromatase as well, that
enzyme that's involved in converting
testosterone into estrogen. So,
believe it or not, when you're a boy
developing in your mom's womb, estrogen
plays a very important role in your
brain and brain development and what's
called masculinizing the male brain. You
actually, it's kind of contradictory.
You're like, "Oh, well, wouldn't
testosterone do that?" Well, actually,
estrogen is very important for
masculinizing parts of the male brain.
And so when you have aromatase being
inhibited by bisphenol A by this
endocrine disrupting hormone that is so
ubiquitous everywhere
>> that is found in plastic bottles
>> plastic bottles it's it's found in yeah
it's found everywhere.
>> So what what do you recommend?
>> First of all I think if you can uh
eliminate and not drink out of plastic
bottles as much as possible. If you do
want to go coffee either drink it there
in their mugs or bring your own to- go
mug. Like I bring my like I have like a
Yeti kind of to- go coffee mug that I'll
bring into a Starbucks or wherever
coffee bean and I'll have them fill it
up. Soup cans canned soup are lined with
BPA. They're lined with plastic and soup
usually goes into the can hot sterile
technique. I mean they they want to make
sure it's so you're getting the soup has
been classically shown in multiple
studies to me to to increase BPA levels
by a thousand%.
Crazy amounts. So, don't eat canned soup
as much as possible. I mean, obviously,
this is about the habit, not the
one-off, but but you know, try to avoid
cans, drinking out of even soda cans,
even like your your favorite sparkling
water cans. Don't make it a daily habit
because they are lined with plastic.
That's a source of BPA into your bodies.
There are ways that you can excrete BPA.
So, the major way to get rid of it is
through urine. It's excreted through
your urine, but it has to become water
soluble first. It's a fats soluble
compound. And so there are things that
we can eat in our diet that will
increase that excretion. Compounds in
broccoli. Broccoli sprouts being the big
one. Sulurophane activates a pathway
that are enzymes involved in making BPA
become water soluble. So they come out
your urine.
>> Oh, so broccoli is like a cleanser.
>> It's like a cleanser. It's like we we
actually do have these it's called phase
2 detoxification enzymes in our body. We
have the ability to detox a lot of
things. We just have to give our body
the right, you know, input so that it
can activate those pathways. I
personally take a supplement of that
sulfurophane because I want a
concentrated amount of it because I used
to do broccoli sprouts. Broccoli sprouts
have a hundred times more sulfurophane
than mature broccoli, but you have to
sprout them and then there's
contamination issues and it's just, you
know, some people do it. It's great, but
I used to do it. I don't anymore. I just
take a supplement.
>> That supplement's called
>> The supplement I take has is called
Avacol. It's by a company called
Neutramax. I don't um you know I'm not
like affiliated with them. I like their
supplement because one they've got 12
published studies using it. Clinical
studies too showing that it actually
helps with um autism children and
adolescence with autism that take the
sulfurophane supplement that they have
improved symptoms because it's a detox.
It helps interestingly people with
autism are like 30 times less likely to
excrete BPA. It's a weird thing going on
here where BPA increases autism spectrum
disorder, but then kids that have it are
not able to detoxify it as well.
>> Wow.
>> Yeah, it's interesting. Again, I think
that excretion is important, but
avoiding avoiding the plastic as much as
you can. Make it a habit. Don't freak
out. I mean, obviously you can like make
yourself crazy and stress is not good.
As we talked about, I see you like
going, "Oh my god."
>> Yeah. Know, I'm thinking about just how
casual I am about these things, though.
And I could I could easily make small
changes. I I could frankly I could easy
make big changes in the position I'm in.
I could just say I can say in my company
we no longer buy this kind of stuff. I
could say in my kitchen cuz you know to
my team or whatever. Let's not buy this.
Can we go look at my kitchen now?
>> Let's do it. Let's go. Let's go to my
kitchen. Be right. No, you guys can come
too. So we're going to go to my kitchen.
If you're Listen, if you're listening on
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you're about to go into my kitchen and
we're going to look at real things that
you might not even know in your kitchen
are causing you some of these problems.
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Okay, so the team have been here for the
last couple of days. We've been getting
lots of takeaways. And so this is a
higgled piggledy of everybody's food.
What's wrong? You got you're pulling
>> black plastic.
>> What's wrong with the black plastic?
>> Um, we talked about plastic. It has BPA.
It has phalates, but it also typically
is made from recycled electronics. And
the problem here, Stephen, is recycled
electronics have flame retardants in
them because you don't want your
electronics catching fire. And there
have been a variety of studies now that
have found that black plastic has a high
amount of these flame retardants that
are leeching into the food and getting
into people's bodies that way. Not only
do you not want to eat out of black
plastic, you don't want hot food going
in there, right? Cuz that's like the
worst.
>> Can I get a bin bag? I need a bin bag.
Okay. Okay. So, let's throw that in the
bin. What else? I'm going to take all of
it out.
>> Okay. This is the other thing that
really reaches out. Stands out to me
because
spicy foods, anything acidic that goes
into plastic causes the chemicals to
leech into it even more rapidly. Kind of
the same way the heat does. So, heat,
acidic foods, not good in plastic.
>> So, my spicy sauce, if it comes in a
little plastic tub, it's going to leech
in.
>> Look, if it's the oneoff, okay, but like
not a habit. Yes. A big time leech in
it. You're you're you're eating BPA hot
sauce.
>> Okay. So, the black stuff is out and
>> it's going in hot.
>> Yeah, this has phalates and had BPA. I
mean, look, are you drinking this every
day or is it the oneoff?
>> No comment. No comment. Mind your
business. Okay. What else? What about
this?
>> This is made of paper.
>> Here's my little thing I do. See that
waxy? There's a waxy
>> a pas
>> on the edge.
>> Yeah. Does it seem like it has a waxy
substance to you?
>> Yes.
>> This is This is better than the black
plastic. If you had to like if there's
like tears, this is better than black
plastic.
>> Okay. And this
>> ding ding ding. This is great. This is
the best thing that you can do if you're
going to have food made for you or you
want to order takeout, have someone make
it for you and deliver you in this.
>> And this is a bamboo lid.
>> Bamboo lid with with GL Pyrex glass,
right?
>> Okay. So, this is what this is good.
>> This is great.
>> So, I need more of this.
>> You need more of this and get rid of all
I mean, this is already looking better.
This is on the scale. At least it goes
in cold. So, here's the thing.
Microplastics are also shedding into
this. We didn't talk about
microplastics. They're shutting into
here. the chemicals, not as much in
something like this, but they're still
getting in. So, this is a little bit
better when it comes to like the the
tears here. The hot food is the worst.
This is a little bit better, but I still
would get lettuce
>> because it's cold.
>> Because it's cold.
>> So, it's not seeping.
>> Exactly.
>> Okay. So, I might be able to keep that
then. What else do you notice here?
>> So, I noticed that I really like your
glass sparkling waters. That's great
because, you know, glass is is less
likely to have microplastic shedding,
less likely to have the chemicals.
>> There was a study that actually found,
interestingly, there were more
microlastics in on the top. So, the
paint that's on these lids, plastic
polymers are used in that. And during
the processing and, you know, bottling
up of these things, they get into the
the the water. And so, believe it or
not, glass bottled water has more
microlastics than plastic bottled water.
Okay, this is terrible. But I'm going to
tell you why I think this still is
worse. Okay, so this is got
microplastics, but it also has BPA and
phalates. They're in this water. This
was not always cold. It's, you know, it
was some warehouse shipping container.
Who knows how it got here? It's been
heated up, I'm sure, several times. The
problem is is that there was a study
showing that glass bottles have a higher
amount of microlastics than than
plastic. And you might go, why is that?
Because they're all coming off on this
paint and getting in. When it comes to
microplastics, size matter. I'm not as
worried about it having more
microplastics because it would show that
they were large microplastics. Your body
doesn't absorb a large ones very well.
They come out through your feces. These
This has tons of what are called
nanoplastics, very, very small particles
that get into the gut and get into your
bloodstream. So, I still go for the
glass water. So, I would avoid drinking
out of these as much as possible. So, I
like how you have these condiments in
the glass. This is how my refrigerator
looks as well. I'm very, very obsessive
about anything that has acidity in it,
like hot sauce and ketchup. It needs to
be in glass because the acidity is
leeching microplastics and BPA and
phalate chemicals into your condiments
and then you're putting that on your
food and you're eating them. Again, this
is ubiquitous. It's everywhere. Plastic
is everywhere. The chemicals are
everywhere. And you're not even thinking
about the fact that your hot sauce and
ketchup are also, you know, vehicles for
delivering these microplastics and, you
know, their associated chemicals into
your body. So, I really like these.
Like this one, I would go for a glass
mustard. Those those are better.
>> Glass bottle. So, this is plastic. Same
thing. It's acidic. I would say um you
know, for the most part, the butter. Oh,
yeah. This is bad. Is this butter? Oh,
cheese. Yeah. So, this is a problem
also. So if you look at this um it's
that flexible plasticky stuff, right? It
has phalates in it.
>> Well, this this
>> Oh, that's even worse. This is Yeah. So
this is the plastic that basically, you
know, phalates are in this and they're
fat soluble and they are just leeching
into this fatty cheese. They're leeching
into the fatty cheese. So you can buy
cheese that's like without this in just
the container that's a little bit
better.
>> You know what I mean? Like like I'm
thinking of feta cheese for example.
Like some feta cheese comes in this
plastic wrapper, but you can buy it with
just the container and at least it's not
like close like with juices like just
seeping into it, you know, getting the
chemicals into it.
>> Ah, but this is fine, isn't it?
>> Eggs.
>> Yes, eggs are great.
>> There we go.
>> Eggs are great.
>> We found something.
Okay, Vonda. So, spatulas and kitchen
utensils. Are these good? Are these bad?
What's What's the best?
>> Yeah, good question. These are great,
right? Okay. There's no plastic here. No
possibility of plastic leaking into your
foods. You got your nice pasta spoon.
These are silicon, I'm imagining. Um,
>> in theory, the silicon should be okay.
Um, the problem is is that there's a lot
of silicon that actually still has it's
mixed with plastic, too. So, I go for
the wood ones that are like this, like
the wooden spatula. That's what I use.
You in theory should be good. In
practice, a lot of silicone that's been
measured out there and tested does have
plastic. So, I would say if you want to
really be careful, I would switch.
>> But most people at home probably have a
plastic spatula. Is that accurate?
>> Most people at home have plastic spatula
and a lot of people also have black
plastic spatulas, which again back to
that black recycled electronics, flame
retardants, these are cancer-causing
chemicals in there. Bromelated chemicals
that are causing cancer. So yeah, I
would say that even shifting from the
plastic to this is probably a step up,
but I don't know that this is just pure
silicon. I I I I would guess that
there's some plastic still in it. And so
if you're heating it up, the plastic,
it's getting into your food.
>> Okay. What about um my my pans? So what
about Got my pans here.
>> Great. All clad. This is what I use.
These are amazing.
No plastic lining, no PAS, no nonstick.
So, most people's pans at home have a
sort of a protective layer here that's
nonstick so that they can cook their
food and their food doesn't stick to the
pans. Like scrambled eggs, they're kind
of a pain in the butt if they stick to
everything. That has the forever
chemicals in them and that is being
heated up and is leeching into your food
and you're eating it. So, really what
you want to avoid the most is uh Teflon,
right? Anything that's nonstick.
>> It's harder to cook with these though.
>> It's so much harder. But you know what?
you're healthier and that's what you
have to imagine.
>> The other thing I want to talk to you
about is this.
>> The blender.
>> Ah, yes. The blender. This is one that
people often miss. The problem is most
blender
tops here that's blending your stuff is
plastic. And there are studies showing
that when you have a lot of friction on
plastic, that releases orders of
magnitude more microlastics. And of
course, their associated chemicals are
hitchhiking along there. There are
companies that make a stainless steel
version of the blender, and I highly
recommend if you're someone like myself,
I like to do my kale blueberry
smoothies, that you switch to the
stainless steel. I did. I switched for
my family. Um because essentially the
friction, you're drinking microplastics
and chemicals. So that's bad.
>> A receipt.
>> Yeah, don't touch it.
>> What What do you mean don't touch it?
>> Um so receipts are
>> Why are you touching it like that?
covered with BPA. I mean, literally just
covered. That's how it prints it, right?
This isn't like a printer. This is
printed. It's a thermal paper and and
the BPA is allowing the printing to
happen. And so, they're covered with
bisphenol A. People that are handling
receipts, like cashiers that are
handling receipts, have really high
levels of BPA. Um, particularly if they
use like hand sanitizing lotion or any
lotion, any sort of cream makes the BPA.
Again, BPA is fat soluble. these creams
um the hand sanitizers are carrying it
inside to your inside your bloodream
about a hundfold higher than not having
that. So, first of all, you can opt to
have an receipt emailed to you if you
need the receipt. I would do that or,
you know, don't touch it. But also, if
you work in the cash, if you're a
cashier and you work in this industry,
really, really, please wear nitrial
gloves. I mean, this is like your BPA
levels. If you were to go get them
measured, which you can, there are
companies out there now that do measure
BPA levels in urine, you will see that
they are extremely extremely high. So,
um, nitro gloves will protect you from
from the BPA getting across your your
dermal barrier and getting to your
bloodstream. Uh, latex gloves do not.
So, make sure they're nitro gloves. And
for people that are not in the industry,
try to avoid the receipts. I mean, it's
a really big exposure to BPA that people
aren't even realizing.
>> I can tell by the way you're like
grabbing the corner of it like it's
feces or something.
>> Oh, it's terrible. And my son, like, you
know, kids love paper. And of course I
don't want them touching it because we
talked about that study in adolescent
boys where they had high BPA levels and
that was associated with a 50% reduction
in testosterone. I mean this is at a
part of your life when testosterone is
you know important for sexual
development and development in general.
So really really really important to
remember receipts are a very big source
of BPA that people are not thinking
about particularly people that are
routinely handling these receipts. And
um the other thing I want to talk you to
you about is water.
So here is one of my water filters. I
also have a filter attached to the tap.
What are your thoughts?
>> So this is filtering water, but it's
filtering it into plastic and it's also
got plastic filter.
>> So I think that you know you're probably
filtering away some other things,
pathogens, gross other chemicals that
might be in the water, but you're
essentially reintroducing the plastic.
So I don't know that that's necessarily
the best way to get the filter. What you
have over here is a reverse osmosis
water filter. That is absolutely the
ideal reverse osmosis water filters
filter out microplastics, nanoplastics,
BPA, phalates, chemicals, all these
things that we're talking about today.
People can get a tabletop one kind of
like this is tabletop, but it's a
tabletop reverse osmosis water filter.
These only filter out the bigger, larger
plastic size, microplastic size. And
then the last thing I want to mention,
Stephen, because you do have a reverse
osmosis water filter, is that it does
filter out a lot of small particles,
including essential, you know, trace
elements and some essential like
minerals and stuff. So, you want to make
sure that you are taking a multivitamin
mineral supplement. And you can also get
what's called little essential um
element drops that have things like
phosphorus, maganese, iodine, some of
these things that are being filtered out
of your water and making sure you're
reintroducing that to your water.
>> H Okay. So, it takes some good stuff out
too.
>> It does. Yeah.
>> Okay. Is there anything else that maybe
is either in my kitchen now or not in my
kitchen that is a culprit of BPAs and
pouls?
>> Yeah. Here's the first problem here. And
then inside where the hot water is going
through is there's plastic pieces. So
the hot water is going through plastic
to get to your little espresso, you
know, cup here. These I actually looked
into this cuz at first I thought they
were lined with plastic. They're not. My
concern is mostly the water going
through the system that's heating up.
It's going it's got plastic, you know,
piping in there that it's going through.
>> Okay. So I'm going to just stay there
and I'm going to just grab
Okay. So this is now the coffee that I
drink called contier.
>> Um they flash freeze it at the perfect
moment and it's delivered frozen. So
metal and then this is an aluminum lid,
>> right? So it shouldn't be lined with
plastic, right?
>> You go like this, press the little
button on top and it goes straight into
your glass and then this
comes out and that's the coffee.
>> Oh, I love it.
>> So you just drop It's funny cuz they're
a sponsor.
>> Oh, should disclaimer and I'm also an
investor in this company. So, um, no no
machines at all. Put it straight into
the glass, pour the hot water in, and
that's it.
>> So, it's like in instead of instant co
It's like instant coffee, but it's real
coffee that's been frozen.
>> It's from some Stanford engineers who
flash freeze it at the perfect moment to
lock in the taste. And you can literally
smell
>> Smells good.
>> Smells good. Yeah. Um,
>> yeah. I'm so glad you're not putting it
in a machine cuz that's
>> No, no longer do that. Okay. So, this is
my supplement cupboard. It's a It's a
mess, but I've pulled out things that I
that I'm personally interested in, good,
bad, indifferent. The first one that
jumped out at me when I was looking is
reduced and active glutathione.
This is something that um I think people
should be aware of. There's marketing
involved here. Glutathione is in a major
it's a major antioxidant. We make it in
our body. We make it in our brain.
>> What does it do? Sorry.
>> So, it's a very important antioxidant.
It helps negate oxidation which is
causing brain aging. It's it's negating
oxidation which is aging yourself.
Right. M
>> people want to supplement with it
because they've heard about glutathione
and how beneficial it is and how it's a
great antioxidant. The problem is
because our body makes it inside of our
cells inside of our cells. We don't have
a transporter to get glutathione from
the outside of our cells like if we eat
it and if it makes it through our
digestion, which it really doesn't, into
our cells. And so this kind of
glutathione isn't going to make it
inside of your cells.
>> So this is just a waste of time. It
>> it is. You're going to want to get
something called liposomal glutathione.
Liposal glutathione has been shown to
get inside because liposomes it's
essentially taking the glutathione
molecule and encapsulating it in
something that's going to fuse with your
cell. Liposal products in general have a
higher bioavailability for that reason.
>> So let me repeat that back to you. So
I've got it. So if it's liposal, it's
basically in a packet which can get
through into the cell. If it's not, this
one is um reduced and active. Then it's
never going to get in the cell. So it's
waste of time. It's just going to be
excreted. Yeah, I would say that it's
really not doing much and that if you're
going to want to supplement with liposal
glutathione, that's what I have.
>> What about this vitamin D3? I've always
been confused because people say take
vitamin D, but then this one says D3,
>> right? D3 is the form of vitamin D that
you make when you're in the sun. That's
the major way we make vitamin D is from
sun exposure. There is a plant form of
vitamin D called vitamin D2. It's found
in things like mushrooms, for example.
The problem is is that there have been
studies showing that vitamin D2, which
is unfortunately what a lot of
vegetarians take because they want a
vegetarian form. Vitamin D3 is also
found in like sheep skin because the
sheep are making it in their, you know,
skin when they're exposed to sunlight.
Um, vitamin D2 is not as effective as
vitamin D3. If you are a vegetarian or a
vegan, you're going to want to look for
vitamin D3 from lychen. Lyken is that
like green stuff that you can find on
trees and stuff that also makes vitamin
D3 and so it's a it's a much better
option than getting the vitamin D2 which
is what a lot of vegetarians do. So
there's actually a a study, recent study
showing that people that are vitamin D
deficient, so they're not getting enough
vitamin D3 because we don't go out in
the sun anymore. They have accelerated
aging. And if they supplement, this is a
very large study, by the way, if they
supplemented with vitamin D3, they
slowed their their biological aging by
almost 2 years. That didn't happen in
people that were not vitamin D deficient
from the start. So it's not like a
vitamin D3 supplement is going to do
something miraculous if you already have
enough vitamin D. The the point is to
avoid deficiency and so you know someone
like yourself that does probably doesn't
go outside a lot but also well you go
outside but you're not you have darker
skin so melanin is a natural sunscreen
and so people with more melanin have to
spend a lot more time in the sun and so
that is something to consider as well.
Well, I can always just take my
multivitamin,
>> right? Multivitamin. I think I might
have talked about one study last time we
talked last episode where men and women
that were older adults, they were 65
years and older, they took one
sententrum silver a day. And I'm not,
you know, I'm not advocating for
sententrum silver. I'm just saying that
was involved in the study. And um after
3 years, they had reversed their brain
aging, global brain aging by 2.1 years.
And they reversed their episodic brain
aging by almost 5 years. So episodic
memory is the kind of memory involved in
remembering events and people and things
like that you know as you get older you
know that stuff doesn't come as quick
right so it delayed that aging by 5
years well this same study also um just
recently published literally like a
couple of weeks ago again part of this
large study it's called the Cosmos study
they looked at the multivitamin use and
biological aging epigenetic aging and
they found that the Centrum silver
multivitamin also slowed slowed
biological aging, epigenetic aging by a
few months and this was only after two
years and you might go oh a few months
but that was after two years and that
that trial was two years long. So if you
add two two years and then you add
another two years and then you add and
then you're talking about 20 talking
about 30 talking about 50 years that is
slowing aging the entire time. It adds
up. It's cumulative and it's one of the
easiest things that someone can do to
basically you know make sure that
they're aging better. There's things
that are harder to do, but that to me is
such a lowhanging fruit. It's easy.
>> What is it about this? What is in here
that's making a male multivitamin have
such profound effects?
>> If you look at the back at the the
supplement facts, there's a lot of
vitamins and minerals. Things like
vitamin C, vitamin D3, vitamin E,
vitamin K, nascin, the B vitamins,
folate. You have things like selenium,
the essential those essential elements.
These are all things that we need to run
everything in our body. All of our
metabolism, our neurotransmitter
synthesis, our immune system, you know,
our our liver, all these these these are
co-actors that are really important for
all those things. And you don't realize
how important they are until time goes
on and things start to fall apart. It's
basically filling the gaps because we're
supposed to get this these things from
our foods. We're supposed to be getting
all these vitamins and minerals from our
foods, from from our water, and it's
just not happening for many reasons.
One, our soils are depleted. You know,
the organo phosphates like glyphosate is
depleting our minerals. And so the foods
that are being grown in the soil aren't
getting their minerals that they're
supposed to. And then the second problem
is we're not eating the right foods
because we're taking we're eating
takeout. We're eating foods that are not
micronutrientdense. Things like dark
leafy greens. We're not eating the
colors of the rainbow. And those are
really important for vitamins and
minerals.
>> So I've got two questions there. Is
there a multivitamin that I could take
that is not good for me? Because when I
go to the shops, there's so many
different types these days and I don't
know which one's good, bad or how to
tell the difference. And so honestly,
sometimes I just go based on the most
expensive because I assume the most
expensive is the best quality.
>> Yeah. So, you know, the problem with
supplements is they're not regulated. I
mean, not that I necessarily want them,
but it is a problem because supplement
companies can kind of put whatever they
want in the supplements. They don't
necessarily have the amount of active
ingredient that they say or they can
either have too little or too much. And
so that is the problem with
>> too much.
>> Yeah. So for example, some vitamin D3
supplements and some um melatonin
supplements have like some in some cases
like a,000 to 10,000fold more. And it
was a really big problem with melatonin
because melatonin is that hormone that
you make to help you fall asleep and
there was excessive amounts in them. So
it's not regulated. So that you really
don't know the amount you're getting.
So, I would say number one, go to a
trust trusted brand that is thirdparty
testing. There's so much thirdparty
testing now. Consumer lab does it. You
can, you know, look up what they've
tested. But for a man, I would say the
thing that's essential here is you don't
want to get iron. You don't want
supplemental iron.
>> Well, someone told me to start drinking
these iron drinks.
>> Were you iron deficient?
>> No.
>> Okay.
>> I was just sick one time and they said
this would really help.
>> So,
>> this wasn't a scientist, just a friend.
Most men do not need to supplement with
iron unless they have, you know, a
problem with iron and they're anemic.
For example, iron can be very bad. I
mean, if you're supplementing with iron,
it's very reactive and it causes uh
oxidative stress easily. It's called
free iron. The free iron reacts with
other things with your DNA, your cells.
And so, most men do not need to sell. In
fact, even you know something called he
hemocchromattosis where there you're
basically you have too much iron already
and you if you have those genes it's
actually quite common then you're really
talking about iron overload. So you
really do not need a supplement with
iron.
>> Women
>> women premenopausal women are different
because premenopausal women do lose a
lot of iron from menration when they're
menrating. And so I would say about 16%
of of menrating women are iron
deficient. And then if you add exercise
on top of that, you know, a lot of
endurance exercise, you can get licis of
your red blood cells. And so you do need
iron for your red blood cells. If you're
eating meat, if you're not a vegetarian,
you know, maybe that would be a case if
you're like a vegan or something, maybe
some iron could come in, but you have to
get your iron levels measured. You don't
want to be too high because it is it
does cause damage.
>> But I would say that premenopausal
women, iron is especially around your
cycle is good. Post-menopausal women,
once you hit menopause,
>> it you kind of shift to like what a men
needs. You don't need the iron again.
So, it's very it's very much just
premenopausal women that need iron.
>> That's so funny. I've been drinking
these. Omega3. Does that
>> Yes. Omega-3 fish oil, as we've talked
about before. I mean, this is probably
one of the best and easiest things that
people can do to improve their health,
improve the way they age. Um, omega-3
fatty acids. 90% of the US population is
not getting enough of them. 80%
globally, everyone. Nobody's getting
enough omega-3 fatty acids, particularly
from seafood. So the EPA and DHA from
fish oil are probably the best forms.
You know, we talked about studies if you
have a high omega-3 index, you have a
fiveyear increased life expectancy
compared to low omega-3 index. If you're
a smoker and you have a high omega-3
index, then you're going to live as long
as a non-smoker with a low omega-3
index, right? I mean, so the low omega-3
index is like smoking. Basically, you
know, you have a 66% lower chance of
getting Alzheimer's disease with a high
omega-3 index. And even more recently,
there were studies showing that omega-3
slows epigenetic aging. Um, and this is
this is not just a in deficiency. I
guess because everyone's deficient,
maybe that's why, but um, a study showed
that omega-3 fish oil supplementation.
This was a study out of Switzerland.
These individuals are mostly active.
There were 88% of them were already
physically active at the start of the
trial. And I mentioned that because the
trial involved omega-3, it involved
vitamin D, and it involved resistance
training or the combination of all
three. And only the omega-3 was able to
slow epigenetic aging, biological aging,
because for one, they were already
physically active. So adding resistance
training on top of their baseline didn't
do much. And they were vitamin D
sufficient. So the omega-3 was able to
slow epigenetic aging. The combination
of all three slowed it by four months.
This was just after one year.
>> So slowed it by four months. And if you
imagine that, uh, it doesn't sound like
a lot. Again, it's compounding, but also
within that study, they looked at
realworld outcomes. So that also
correlated with they had a 60% less
likely chance of being pre fail uh pre-
frail. So pre-frailty, right? Um they
also were less likely to get cancer as
well. So I mean it's really kind of
translating to these health outcomes
that we think of. And all you need to do
is supplement with about 1.6 to two
grams a day of omega-3 to get a good
omega-3 index. But I will mention one
thing, Stephen, it's at room
temperature. I don't think that's a
great idea. Um because fish oil is a
polyunsaturated fatty acid. It is prone
to oxidation. So you want to put it in a
low temperature environment. I keep all
my actually I keep all my fish oil
frozen. Frozen and then when I'm ready
to use it, I put it in the fridge. So
like I have a store of it. I have a
stock of it I buy and then it's in the
freezer and then I put it in the fridge
with the the bottle that I'm using from
and it's freezing it does nothing. It's
fine. It so it's basically just keeping
it really really low oxidation.
>> So I need to put this in the fridge. You
need to put it in the fridge and also
make sure you're getting a quality
brand, right? So, you're going to third
party testing. Again, you want to have a
total oxidation, ideally less than 10.
And there are brands out there that do
have a oxidation less than 10,
>> which means it's more fresh and pure.
>> It's more It's Yeah, it's less oxidized.
You don't want to be consuming oxidized
fat because that's also not good.
>> Okay. So, what else jumps out to you
here? We've got creatine. I mean,
>> yeah, creatine is like my new I travel
with it everywhere. You got microionized
is this this is
>> I've got so many different types,
>> right? This is the one I take. Yeah, I
take I take the creatine monohydrate
because it's the most wellstudied
>> and you know obviously for I do a lot of
training and workout train you I do a
lot of resistance training and strength
training. So I at least get five grams a
day which is what I always was doing in
the past. I up that to 10 grams a day as
my baseline because I wanted to have
benefits in my brain. Studies out of
Germany show that once you get to the 10
gram mark, you're actually your brain is
able to take it up and it's increasing
creatine in certain brain regions. That
doesn't happen much at lower doses and
that's because your muscles are very
greedy. The creatine in my brain,
honestly, I've for me, I've mentioned
this before, it's a game changer just on
a daily basis. I feel like I don't have
that afternoon slump. I'm in my mid-4s.
My brain isn't as sharp as it was.
Creatine has really helped me kind of
get a little bit closer to where I used
to be. And also when I'm sleep deprived,
I go up even higher. Sometimes I do 20
25 grams. And that is because studies
have shown if you go up to a higher dose
like that, depending on your weight,
it's kind of a scale. Um that it helps
you basically negate the negative
effects on your brain from sleep
deprivation where not only are you
cognitively functioning, you're
functioning beyond what your even normal
baseline was, which was kind of
mind-blowing. The question I had is
around loading and how long it takes to
feel the impact. Because when I first
heard about creatine, I was 16 and my
brother was bodybuilding and they were
told that you need to like load up on
big loads of it and then in like two
weeks time your body would be saturated.
What's the truth?
>> Right? So the reason that creatine
loading was done was because they
there's a short window of time when
researchers are doing a study
>> and they want their muscle stores to be
saturated. They want their their muscle
stores to be saturated and so you have
to do 20 gram loading phase in order to
saturate them after you know three or
four days.
>> If you're not about to compete and if
you haven't been using creatine and
you're not participating in the study,
it takes about four week 3 to four weeks
of five grams a day consistently to
saturate your muscle. So you don't have
to do any loading phase. If you are
supplementing with five grams a day and
you've been doing it for a month, your
muscle stores are saturated until you
exercise and you get that five grams in
again. They're saturated, right? So,
they keep they're they're already that
five grams a day is keeping them
saturated. And that's why I said your
muscles are really hungry and greedy.
They're wanting that five grams. They're
wanting that five grams. And that's
about what it takes daily to saturate
them. However, if you're starting from
ground zero where you've never taken
creatine, it's going to take four weeks
to really get the effects. Otherwise,
yeah, you'll have to get higher doses.
are not going to be saturated after 5 g.
>> So, some people might have tried
creatine for a week, have not felt any
effect, and given up.
>> That's a good that's actually a really
good point. Yeah, it's about a
month-long experiment. I would say close
to four weeks. I think some people can
saturate it at 3 weeks, but it all
depends body size and all that. So, four
weeks is a good experiment time and five
grams is a good dose to start with. If
five grams a day actually help makes you
more bloated and nauseous, cut that down
to 2 and 1 half and 2 and 1/2 grams so
that you split the doses. If you split
the doses, if you take it with food,
particularly carbohydrates, it seems to
help negate some of the bloating and
nausea and negative effects people feel.
And obviously, if you're not working
out, you know, creatine is not going to
like grow your muscles. You have to put
in the work. You have to put in the
effort. It's what it's doing is it's
helping your muscles, you know, grow and
give you the energy to to do more
training volume so that they can grow
bigger and also so that you can be
stronger. If you're traveling and
stressed and all those things, yes,
creatine is good for the brain. I was
seeing I think it was James Smith did a
video about different creatine
percentages in the creatine products we
drink and um or eat or consume and he
looked at creatine gummies and found
that some of the creatine gummies don't
even have any creatine in them at all.
And it was quite shocking because you
just assume that if it says creatine
there's going to be creatine in there.
>> This goes back to the whole problem
where supplements are not regulated and
so you never really know what you're
getting and you have to have third party
testing and go to a quality brand.
Gummies in general. So, there was a
study that was published not long ago.
It was a consumer study that was done
where people went and got a lot of
different creatine gummies off the shelf
and then measured how much creatine was
in them. And essentially almost all of
them had none. And I've talked to some
supplement manufacturers and their
basically their statement was it's
really hard to get active ingredients in
gummy in general, not even just creatine
in general. But the other thing I did
want to mention with creatine is that
you do want to make sure it's NSF
certified. That's a really important
thing because there are contaminants
that are even produced in the processing
of creatine and creatine monohydrate.
And so you want to make sure that you're
not getting those contaminants which can
be harmful. And some of them are like
lead for example, but even some other
compounds that are formed. And so you
want NSF certification. And that's
always what I look for when I'm buying a
creatine supplement is NSF certification
or any supplement. I really like to have
all supplements NSF certified because
that really means they've one looked at
contaminants and two it's got that
active ingredient in there and that's
really what you want.
>> And the NSF certification is just a
little logo on the side of the tub here
that says NSF certified sports.
>> That's it. Yeah. And it's all on
websites, too, if you buy online. Yeah.
>> Okay. So, I've got one challenge for
you. If you had to pick five supplements
for me to take, assuming that I am
male and female.
>> Okay.
>> Okay. So, it's neither gender. Um, and
it can be things that are either
currently in my cupboard or not. What's
the top five? And ideally, give me them
in order if you can, in order of
importance.
>> Fish oil
>> number one.
>> Number one,
vitamin D.
Multivitamin.
All three very very strong evidence that
you're going to slow aging, you're going
to improve your brain function, lower
disease risk, live longer, and creatine
is going to be there.
>> So that's one, two, three, four.
>> And then the last one is magnesium.
Magnesium would be I mean it might be
number four and creatine number five
actually.
>> Really?
>> Yeah. Um
>> you sure?
>> What is magnesium doing for me?
>> Magnesium is running. It's important for
300 different enzymes in your body. It's
important to repair damage to your DNA
that's being done all the time. It's
being done from the iron that you're
taking. Um, it's being done from normal
metabolism, normal immune activation,
but when you're in a state where you
have you're, you know, not eating a good
diet or you're not getting enough sleep,
magnesium is really important to repair
that damage. And that's why studies have
shown that magnesium is really important
for preventing cancer. And it also helps
with sleep. It's really good for sleep.
But more importantly, 50% of the
population doesn't get enough magnesium.
And I bet you're probably one of those
people because most of us are. Do you
eat a lot of dark leafy greens or
almonds?
You're supposed to be getting 400 about
350 to 400 milligrams a day. Are you
physically active? Yeah. You're sweating
magnesium out. Let's make it six
supplements. So, there's a new
supplement uriththn that I'm pretty
excited about. The other thing I take
that's really important is that I don't
necessarily see here.
>> What's it called?
>> Um, so curcumin. All those supplements
you've mentioned, the first one which I
can't say and the second one cumin, we
have on the table in the studio. So,
let's get back into the studio and we'll
pick up from there.
>> Steve, what are you doing?
>> Uh, just making myself a delicious
coffee
>> from the freezer.
>> From the freezer? Have you not heard
about Compier?
>> No.
>> Oh my gosh, this is going to change your
life. A couple of months ago, the
founder of this business called Matt
sent a big shipment of this coffee to
our office in London. What most people
don't know is that the processing of
coffee takes out a lot of the taste. So
what they do is they flash freeze it at
the optimal moment when it's most tasty
and they send you in the post the coffee
in these little frozen ice cubes. Now
Max sent a big shipment to my office. I
moved it to the kitchen. I said to the
team, "Knock yourselves out." And then I
saw so many messages in our Slack
channel of people going, "Oh my god,
what the hell is that? It's so
delicious." All I have to do is pop it
out in the morning using the little
button on the back of this thing. I pour
my hot water in and I mix it and that is
done. You can get $30 off your first
order of Cometier coffee if you go to
cometier.com/stephven.
Try it and please Instagram DM me,
LinkedIn me and let me know if you love
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in a while you come across a product
that has such a huge impact on your life
that you'd probably describe it as a
gamecher. And I would say for about 35
to 40% of my team, they would currently
describe this product that I have in
front of me called Ketone IQ, which you
can get at ketone.com
as a game changer. But the reason I
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the reason why they they now are a
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that this company have been in touch. So
I went upstairs, tried it, and quite
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Game changer. So, if you want to give it
a try, visit ketone.com/stephven
for 30% off. You'll also get a free gift
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first shot is completely free of charge.
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I will speak to you then.
So, phytoal curcumin is another one that
I supplement with. And let's just start
with curcumin in general. Curcumin is
found in the turmeric plant. It's
something that is able to pretty
robustly and I would say consistently
lower inflammation.
And it's doing it in a different way
that like a NSAIDE like an ibuprofen
would do it, right? And that is
important because
it's been shown if you take NSAIDE,
right? So these non-steroidal
anti-inflammatory drugs, something like
ibuprofen
around exercise, it can blunt the
adaptations because it's basically
lowering inflammation and and
prostaglandins and things that are
important to cause exercise adaptations.
So curcumin doesn't hasn't been shown to
do that but it has been shown to lower
something called TNF alpha and that is a
major inflammatory cytoine that is
really really powerfully accelerating
aging. In fact those epigenetic aging
clocks that we talked about earlier one
of the most powerful drugs that's able
to slow them are TNF alpha inhibitors.
So these are drugs that people take to
inhibit TNF alpha. Certain people take
them, like people with rheumatoid
arthritis, they have a high level of
inflammation. Their immune system is
overactive. They're making a lot of it.
Well, guess what? Those individuals
taking TNF alpha inhibitors are like
they have a 50% less likelihood of
getting Alzheimer's disease than people.
>> 50%.
>> Mhm. Yes. So, I like it because curcumin
is one of the most it is the
na most naturally occurring dietary
compound that I've seen data showing
that it lowers TNF alpha. I haven't seen
anything else that's naturally occurring
that does it. This does it. It lowers it
by quite a bit by almost five pogs per
milliliter. Phytoal curcumin is the
reason I take phytoal. It's kind of like
a liposome but it's phytome. So, it's
essentially just making the ingredient
get into the cells better. It's more
bioavailable
>> because curcumin is easily metabolized
quickly by the liver. It's a it's what's
called a xeninoiotic. It's not a
compound that's a vitamin or a mineral
or something that the body body normally
recognized. It's seen as a drug, a
foreign drug, xeninoiotic, right? And so
the liver gets rid of it quickly. The
phytoal delivery of it kind of slows
that whole process where it's not
getting rid of so quickly. It's not
being metabolized so readily. So that's
why I take that. And also it's been
shown to improve performance in people
that are exercising again because it's
reducing inflammation. Inflammation can
be dampening for performance.
>> And what else have we got here?
>> The other supplement that I really want
to talk about is the uraliththan A. And
as I mentioned, this is a compound
that's usually generated in the gut by
the bacteria in your gut. It's something
that we can get from our diet. So if we
eat things like pomegranate, pomegranate
has a type of polyphenol in it called
elagitanins.
>> I've never heard about this before.
>> Okay, listen to this. This is this is
like you got to try this supplement.
Uthin A again, it's made from eating
things like pomegranate. However, 50% of
the population doesn't have the right
bacteria to make it. So you're kind of
like a to a coin toss if you eat
pomegranate. Am I going to be the person
that can make uriththna or am I not?
Right? So there was a company that did
out of Switzerland these stud a lot of
these early studies were done in
Switzerland and they ended up making
uriththn and then testing you know doing
clinical studies doing animal studies
first and then clinical studies to test
you know what is uroliththna doing. So
what is it? It is a compound that is
able to basically get rid of damaged
mitochondria. So it's called mphagy.
You've probably heard of autophagy. you
know getting clearing out your all the
gunk and the trash from your cells
making them rejuvenating rejuvenating
them right
>> which is associated with fasting.
>> Fasting activates autophagy. Fasting
activates mphagy which is specifically
just clearing out damaged mitochondria
or pieces of damaged mitochondria.
Autophagy is essentially you have a
whole cell
>> and within that cell you have a lot of
different organels they're called. So
mitochondria being one and so autophagy
kind of helps clear out all the stuff
inside of the cell. Mphagy is very
specific to just the mitochondria within
the cell. Those mitochondria get older
and they don't have a really good repair
process and so they accumulate damage
and as they get older you're you're not
going to be making energy as well.
You're not going to be using energy as
well. It's going to affect all the cell
function because energy is at the core
of everything, right? So mitochondrial
health is at the core of all health
basically. This compound very robustly
induces mphagy. And so um there have
been of course many animal studies that
were done preclinally before clinical
studies were done. Animal studies were
exciting. I mean mice that were given
old mice that were given uraliththna
were able to like rejuvenate you know
tissues but also 20% life extension was
found in these mice given uralithn. 20%
is pretty big for a mouse mouse study.
All right, but we're not mice. So, let's
talk about humans and why I'm actually
excited about it. For one, urthan A and
mphagy was shown to be activated in
humans taking it. So, they took muscle
biopsies and found that in fact mphagy
was activated. It's also recently been
shown that this uriththnan A is able to
to basically rejuvenate the immune
system. So older adults were given a
thousand milligrams a day and it it
basically as we age our immune system
ages our te- cells aren't fighting off
pathogens as well and it increased the
number of a very specific type of immune
cell that decreases with age called CD8
positive tea cells. Those were
increased. That's very important because
you're able to fight off infection
better. And then it also increased a
kind of immune cell that's able to kill
cancer cells and also kill viruses and
pathogens. it's called natural natural
killer cells. Um so those cells
increased as well with the uriththan a
and it also decreased markers of like
scinsessence. So this is basically when
a cell is still alive but it's not
functioning it's basically like it's
dead but not only is it not dead and not
functioning it's secretreting
inflammatory cytoines accelerating
aging. I know it's complicated. So the
study showed that it was basically able
to re rejuvenate the immune system in
older adults younger adults that have
taken it. So, there's been studies
showing that untrained athletes
supplementing with 1,000 milligrams a
day were able to improve their V2 max um
10% more than just exercise alone. So,
if they exercise and took uriththan A,
their V2 max went up 10% compared to the
exercise alone group. Wow.
>> If they were Yes. If they were trained
athletes, it only went up 5% because
trained athletes already are doing a
lot, right? So, you always get a bigger
increase in B2 max if you have an
untrained athlete. Same with obese
people.
And on top of that, so again, energy,
it's you're clearing out damaged
mitochondria. If you combine it with
exercise, exercise causes you to make
new mitochondria. So the way I look at
it, Stephen, is a rejuvenation of all
your mitochondria within your cells,
whether we're talking about your muscle
cells or your immune cells. I think it's
probably happening in the brain as well.
So it's been shown to increase muscle
strength in older adults. So, their
hamstring strength improved by like 10
to 12% after supplement supplementing
versus just exercise alone. I think it's
a supplement that's important for aging
because it's affecting mitochondria and
pretty much everything relies on
mitochondria.
>> And you can buy this in a normal shop on
the high street.
>> You cannot buy it in a normal shop. You
can buy it online. It's not cheap,
unfortunately. Uh that's the other
thing. So, pomegranate itself is the
next best thing for people. And there
are studies showing that people that
take pomegranate juice before they
exercise they and over over the course
of several weeks can actually increase
their V2 max by up to 17%. This is
analysis of multiple studies showing
that. So again I think it's all coming
down to the uriththna and it's a new
supplement that I'm I've been
experimenting with. Again the immune
system effects. I think I'm not getting
sick but I'm doing the creatine. I'm
doing the uriththna and I'm doing
glutamine.
>> So glutamine is the last one. What what
is that? Well, you probably heard of
glutamine as an amino acid, right? It's
so much more. It's so much more. So,
glutamine is something that it is an
amino acid, but it gets converted into
and metabolized to many different
things. So, one, it can be an amino
acid. Two, it can form something called
glutarate, which is used by your cells
for energy. Mitochondria love it. Or it
can be converted into that
neurotransmitter that we were talking
about, right? Glutamate. So, it's really
something that can be used for many
things. I supplement with it because I
came across some studies in the past
couple of years where endurance
athletes, so these are I'm not an
endurance athlete, but endurance
athletes are very prone to respiratory
illness because they're really just
going hard, right? And their im your
immune system kind of takes a takes it
takes attacks on your immune system.
studies were showing that if those
endurance ath athletes supplemented with
glutamine, they didn't get sick as
often. They were having fewer
respiratory illnesses. And I remembered
back to when I was a graduate student
and I was doing research and I used
glutamine. And I was doing glucose and
glutamine and looking at immune cells
and how I could make them active or what
happens if I get rid of glucose or
glutamine. And I remembered how much
they love glutamine. They consume it.
They're using it for energy.
>> And it started to make sense to me. And
this was during a period of time where,
you know, again, mid-4s, your immune
system is not going doing as well as it
used to. I've got a had a young child
that was bringing home all sorts of
pathogens. And so, I started
supplementing with glutamine. And it
could be placebo, but again, I you know,
the sickness bouts were going down. I
wasn't getting sick as often. The other
thing it's good for is the gut. And that
is because glutamine can be glut uh
converted into something called alpha
ketoglutarate which is a important
energy compound that the gut uses. And
so there are studies showing that it's
beneficial for gut health. I think
that's what a lot of people think about
when they take glutamine is their gut.
I'm thinking about my immune system. But
basically it's very easily used by the
gut cells as energy and that really
helps the gut heal.
>> Okay. The other thing which I take
almost daily. Sometimes I give myself
the weekend off depending on how things
are going, but almost daily are these
ketone IQ shots which I am affiliated
with. I I'm an investor in the company.
Ketone shots, exogenous ketone shots.
>> I take them also quite frequently, not
daily. Um, you know, so what are they
doing? There's different forms of them
and why do I take them and I think let's
talk about what I think people should
realize if they are taking them. So, you
know, there it's an it's it's
essentially giving you that metabolic
switch, right? It's getting getting your
ketone levels up as if you were fasted.
So you're you're elevating your beta
hydroxybutyrate levels. That's the major
circ circulating ketone.
>> Beta hydroxybutyrate,
>> BHB for short.
>> Does that just mean ketone?
>> It's a ketone. It's there are several
ketones. Acid acetone is another ketone,
but that beta hydroxybutyrate is the
major one, right? So and and that is a
major ketone that's in in your body when
you're fasted. That's what you're
making. And when you're taking these
ketone IQs or other exogenous ketones is
what you're going to get. So ketone IQ
is got the precursor for the ketone.
It's got 13 butane dial that in your
liver gets converted into beta
hydroxybutyrate. I take a ketone that
has 13 butane dial but also it's
asterified to the actual beta
hydroxybutyrate.
>> What does that mean? It means that it
has both an immediate action, a fast
action effect of having your ketones
elevated, but it also has a tail end
effect. So the 13 butane dial, if you
take it, you have to wait for it to get
to your liver.
>> You have to Can I have one?
>> Yes. You have to wait.
>> Oh, perfect. Okay.
>> Wow, those taste better. M.
>> So,
so the other ketone exogenous ketone is
the beta hydroxybutysterified
to the 13butin dial which just means
it's going to have a fast acting effect
but also a long-term effect. So you
you'll get a little bit more elevation
in your blood ketones from from the one
that has the beta hydroxybutyrate to the
13bin dial. That said,
>> the difference is I think from what I
know and I don't know a ton is pricing.
>> Yes, it's pricing but also again
concentration. So, I mean, you know,
you're going to get you're going to get
a higher peak quicker and you're going
to get higher levels of it with the one
that's the the Oxford, you know, the
Oxford ketone, I guess it's called, but
the ketone IQ has 13 butane dial, which
does get converted into beta
hydroxybutyrate.
>> This one I think cost costs a couple of
dollars. And I have the Oxford one here
as well, which I think is $30 a pop. So,
it's quite expensive.
The reason why this has been able to
break into retail, especially across
America, is just because it's more
affordable for most people to be able to
take spend a couple of dollars,
>> right? The reason I take it is because I
like the cognitive boost that I get from
it. And I usually take it on occasions
like this when I'm doing a show or I'm,
you know, doing a presentation or I just
I'm doing a lot of heavy research and I
just need to be on because I get a
cognitive boost from it. And that
cognitive boost does come down to what I
was talking about with why I like to
fast. It's mimicking that, right? I have
that beta hydroxybutyrate which is
increasing GABA, that inhibitory
neurotransmitter that's silencing down
some of the anxiety in the back of the
brain or the chatter and just helping me
focus. And also it increases brain drive
neurotrphic factor. So beta
hydroxybutyrate is a signaling molecule.
It's able to increase brain drive of
neurotrophic factor in the brain that
helps with learning, memory, brain
aging. It's also been shown to lower
oxidation. So, there's all sorts of
reasons why I like to take it. For
people that are fasting and they're
wanting to burn fat,
consider that if you take exogenous
ketones, you stop you stop burning your
own fat because your body thinks it's
now got all it's got the ketones there,
which is what the metabolism of fat is
trying to do is produce ketones for
energy. And so, it does shut down what's
called lipolysis, which is basically
breaking down fat. And so if you're
doing fasting and you're doing it for
reasons of fat loss, if you take an
exogenous ketone during that period of
time, it will transiently kind of shut
down that process. So keep that in mind.
It's one reason why I don't do it every
day because I am looking for that effect
for losing visceral fat in particular.
>> That's a really interesting important
point.
>> It is
>> that people don't talk about.
>> Yeah, it's important and it's only going
to last as long as the beta
hydroxybutyrate lasts in your in your
blood system. So, you know, maybe 3
hours max.
>> What I noticed was when I was trying to
get into ketosis at the top of the year
and I was doing exogenous ketone shots.
I was struggling to get into ketosis.
And so, what I did is I stopped taking
the ketone shots for a couple of days,
just focused on my ketogenic diet. I got
into ketosis and then afterwards I
started taking the ketone shots when I
was doing podcasting because just like
you, I noticed just such a radical
radical difference when I take exogenous
ketones or when I'm in a natural sort of
dietary ketosis. Radical difference. And
as a podcaster, I've said this a million
times before, but I'm going to say it
again. Two times a week, I do an AB test
of how my brain is working. I sit with
someone who is an expert in what they do
for sometimes four or five hours and I
look at them in their face and I have to
ask questions and respond and understand
big words and hope that my brain is
connected to my mouth today. And so I've
done 600 or 700 of these AB tests now.
And one of the the factors that
correlates to good performance as an
interviewer, a thinker or a speaker on
stage is whether I'm in a ketosis state
or not. And it's so profound. In fact,
I've actually heard Joe Rogan say this.
Rogan said that the upside he gets from
being in a ketogenic state is so evident
for him as an interviewer that he he's
considered being in that state all the
time.
>> It's the same for me too. I mean, as you
know, I'm also doing the same thing,
right? I'm I have a podcast and I'm
giving presentations and very very much
having to use my brain and be on and
it's really made a huge difference for
me as well. And that is also why I like
to fast because I get the same effect
when I'm when I'm fasted. And then I
will take an exogenous ketone when I'm
also fasted. And so I get into ketosis
quicker as well
>> because I'm already I'm already kind of
there. I don't have other things
inhibiting it.
>> So it does help. And there's again pros
and cons to doing it. You do want your
body to be metabolic flex flexible. So
I'm glad you did do the keto like the
ketogenic diet and let your body kind of
do it and adapt and then add the ke
ketones on top of that. But um they do
help. They help with cognitive function
for sure. I mean I I use them every
single podcast I do, presentation I'm
giving. It's it's part of my routine.
>> Let's talk about something different,
which is something that I've never heard
of before. Um it's a word that you
started to make popular in the health
and longevity community, which is this
idea of peak span.
I have this graph in front of me, which
I'll throw up on the screen. It's
fascinating. What the hell is peak span?
I've heard of health span. I've even
heard of lifespan, but I've never heard
of peak span.
>> Well, let's start with lifespan and work
our way to peak span to give people a
frame of reference. I think most people
are familiar with the word longevity,
>> wanting to extend their lifespan, how
many years they live, how long they
live, right? But the problem with
lifespan is well, you could live longer,
but you're going to have per perhaps you
have some diseases. So why do you want
to live longer if you have Alzheimer's
disease or cardiovascular disease or
type two diabetes? I mean the qual your
quality of life is not as good and
that's where this idea of health span
came in right so health span is well
let's increase the amount of time we
live diseasefree
>> and that's the new thing that everyone
wants to increase and improve their
health span I want to live I want to
increase my health span so I want to
live longer and not have any diseases
while I'm living that that longer life.
Well, there's this new concept now, very
new that was just published by some
researchers out of Duke University as
well as I think um the China
some university in China and another
university, but I want to give them
credit. They just it's a pre-print study
and it came out on my radar. I
immediately loved it. And this is idea
of peak span. Peak span says, hey, you
know, health span is great. Being
disease-free is great, but you're still
in a period of decline. You're still
declining.
Why not try to be as close to your peak
span which is essentially within 90% of
your peak function for a certain
measurement whether we're talking about
V2 max cardiorespiratory fitness we're
talking about you know any any other
function and that's where this graph
comes in on the y ais we have our
relative capacity
>> so if you're listening now this is a
good time to look at the screen because
uh Rhonda's going to show us something
okay your relative capacity 100 being
100% and zero being 0%.
>> What does relative capacity mean?
>> Your capacity for cognitive function for
you know your fertility
hormonal Yeah. your potential. Yeah.
>> And on the x- axis we're talking about
age, right?
>> And so what you'll notice is that
different capacities, different organ
functions kind of peak at different
rates. So we can talk about first
obviously female reproductive
really starts to peak at you know 25 or
so and then it just sharply declines
until you hit 40 right and it's like b b
b b b b b b b b b b b b b b b b b b b b
b b b b b b b b b b b b b b b b b b bmed
out. So that's the reproductive female,
right?
>> Mhm.
>> Immune function. So let's find immune
function here.
>> That kind of peaks around 25 years old
and it also kind of declines and it
keeps declining.
>> It's quite scary
>> as you get to 80.
>> And then we have muscular skeletal,
right? So this is our peak strength,
peak muscle mass, peak bone density.
Those also peak around 25 and then they
kind of steadily start to decline. And
the same goes for cognitive function. We
have two different kinds of cognitive
function. We have fluid cognitive
function like processing speed. That is
the kind of I would say cognitive
function where you can answer a question
without any prior knowledge.
>> Mhm.
>> You know that. So that peaks around 25.
>> You're joking.
>> No, I know.
>> So I'm on the way down.
>> You're on I'm definitely on the way
down. You're on the way down as well. So
that would be the blue one here. Peaks
around 25. And then we have the
crystallized cognitive function.
Crystallized cognitive function is
interesting because it peaks around
midlife. And the reason it peaks around
40, 45 is because it's the kind of
intelligence that it's like the library
where you have all these facts that
you've accumulated over the years and
you're able to use those facts to answer
or solve a problem, right?
>> Is that wisdom or is that
>> It really just means that you have all
these facts that you've learned over
your life. Like for me, you know, I've
been a biologist for since I was, you
know, 20, so 27 years. I have so much
that I've learned over that time. And so
now I'm sitting here and I use that
knowledge. I talked about glutamine,
what I learned from graduate school. I'm
using that knowledge, right? Mphagy, I
learned about that like forever ago and
I've been following it. So you use all
this these facts and this data that
you've learned in your life and you're
able to solve problems. So fluid
intellig I'm sorry, crystallized
intelligence.
>> I've got to ask a question there. I I we
were sat having dinner the other day, me
and my team, and we were talking about
the difference cuz we're all different
ages. We've got someone in the team
who's 45, 35, 30, and it was the other
person at the table was 27. And we were
all talking about the differences we've
noticed in ourselves as we've aged. And
they all said different things. So Leona
and my team, who's just is above the age
of 40, was saying that she just like
doesn't really give a anymore in
the same way that she used to care about
people's opinions when she was 30. One
of the things I said I noticed about
myself was after I turned 30. I feel
like I saw a step change in pattern
recognition and like exactly what you've
just described there which is like
crystallized knowledge cuz I sit here
with experts all day learn all this
stuff from them and then my ability to
then like apply it in my life as an
entrepreneur seems to be improving. And
so the question I was really going to
ask you is you think about
entrepreneurship lot my a lot of my
audience are entrepreneurs in some
capacity or aspire to be. I was
wondering as you were saying that like
when is the best age because
entrepreneurship is a lot about pattern
recognition. It's problem in front of
you. Okay, I've seen this before. I'm
pulling on different reference points to
arrive at a solution. So I was wondering
here because it looks like it peaks at
like 45.
>> 45. So if we look at it, it's peaking at
45. And that's also why a lot of
biologists continue to do great work in
their midlife as well. And that is
something that I do feel like better for
me as well. you know, where I'm I'm now
able to pull on I have so much of a
database in the back of my head, you
know, where it's like I I've got all
this knowledge and then it comes up and
you can use it. And so it's interesting
you can talk about entrepreneurs, but
you can I mean any any sort of career
path, right? What it would be beneficial
to be able to do that. So the question
is then how do we get here's peak span
you're going up and what you want to do
is you want to get and maintain about
90% of all these things that we're
talking about peaking right we immune
aging it peaks at you know immune aging
actually peaks around adolescence I
think muscularkeeletal health 20 25 the
fluid int intelligence 2025 you're
having cardiorespiratory fitness that's
also 20 to 25 it peaks and then it goes
down the question is how do Do you
maintain your peak span? Right? How do
you get as close as you can? You're
obviously not going to be your 100%. But
how do you not drop below 90% of that
peak, right?
>> Is that possible?
>> Is it first of all, is it possible? And
I would say for some organs, no. Which
organs are that? I don't think a
reproductive life expectancy for a
female I don't think you're going to be
having babies at 80 years old um without
actual medical intervention but that's a
whole other conversation. So I but I do
think there are ways that we can get
really close to our peak for
cardiorespiratory for muscle skeletal
you know for our our intelligence
cognitive intelligence as well as our
immune system and I think there are
blanket things that we could do that
affect multiple systems right like and
there's also targeted things so we
talking about fluid versus cognit versus
crystallized intelligence right
obviously crystallized intelligence you
know it doesn't peak until mid-4s you
the things that you can do to improve
crystallized intelligence also improve
your fluid intelligence. What are those
things? One, exercise number one thing.
Aerobic exercise is increasing brain
derived neurotrophic factor. Very
important for both these aspects. It's
also, you know, growing new neurons,
making connections between the neurons,
making your brain more plastic and
adaptable so it adapts to the changing
environment. Top thing that you can do.
Another thing that you can do that's
really important for brain aging is the
omega-3. We talked about that. really
important for brain aging. But the other
thing that you can do is what we're
doing right now. Engaging in novel
cognitive, you know, experiences. It
could be a discussion. It could be your
work. If you are learning new things,
novel is key here. Novel. If you're
learning new things, you are going to
really help yourself improve both your
fluid and crystallized intelligence. And
so,
>> is that because you're raising your
potential? i.e. So you're falling from a
higher place as you decline because I
was thinking about this like how much of
this has got to do with making sure that
I I peak at a higher place
>> right yeah I mean I think that maybe has
something to do with it but in addition
there's neurochemical things that are
changing when you're learning new
experiences for one you are increasing
brain drive neurotrphic factor and stuff
as well because novelty does that you're
also glutamate and you're h you're
having you know glutamate being
activated as well But um yeah, I think
the cognitive reserve is what you're
talking about and that is really
important, right? Because you you need
to you need to have that reserve if
you're going to start pulling from it.
And that also comes with muscle muscle
health, right? Muscle and bone. So those
are peaking around the same times 25 or
so. Peak muscle mass generally occurs
around the age of 25. There are things
that you can do to keep close to that
peak though, right? And that would be
resistance training, big big one.
Strength training. Strength goes down.
This is something protein intake, right?
>> Avoid the black plastics in my fridge.
>> Avoid black plastics in your fridge.
Yeah.
>> Because then my testosterone is going to
go down.
>> Testosterone is going to go down and
that's going to affect your ability to
gain muscle mass. Exactly. A a lot of
these healthy lifestyles that we're
talking about are multi-system
targeting, right? So, you're targeting,
but key would be strength training and
resistance training. And it's going to
also affect your bones. So, you're going
to want to do these weight bearing
exercises that are multi- joint, the
compound lifts, right? the deadlifts,
rows, things like that. Those are very
important to help maintain that peak.
Immune system, sleep, very, very
important for maintaining a healthy
immune system and preventing your immune
system from aging rapidly. So, making
sure you're prioritizing sleep, how you
going to do that, right? I mean, there's
a lot of ways to people people a lot of
people have sleep problems and they have
sleep problems for different reasons and
there's way to ways to target them. But
just realize thinking about it and
prioritizing is important for your
immune system and for your brain. Also
the exercise plays a role in your
cardiorespiratory fitness, the brain,
everything, muscle. So cardiorespiratory
fitness is something that you we talked
about uralithn helping improve it on top
of exercise. So there's supplements and
stuff that you add in as well. But this
idea here is really that we can do
things in our life that are healthy to
help maintain that peak span to get us
not just free of disease but like close
to what we were peing. And I do think
it's possible. I mean we talked last
time I was here we talked about that
study you exercise 5 hours a week do
some highintensity interval training in
there and you can reverse heart aging by
20 years. That's incredible.
>> It's so crazy. So,
>> and you're also saying that listening to
the diary of a sea obviously is
therefore good for
>> Yeah. It's good for cognitive um your
fluid intelligence and your your
crystallized intelligence. It's good for
learning new things, right? I mean,
that's
>> So, you would prescribe it.
>> Yeah.
>> Yeah. Especially the episodes I'm on.
No, I say that as a joke, but actually
it's part of the conversation we had the
other day at dinner was I don't think
I'm going to appreciate maybe until
later in my life how much an unintended
consequence of doing this as a job had
on my cognition and my brain
and it's like not something that I would
notice you know in the moment but over
time you know doing this two times a
week for sometimes eight hours a week
learning something new being forced is a
strong word but having an obligation to
learn something new for eight hours a
week for my entire adult life.
>> It's great. I mean, it's it's one of the
best things that you can do for your
brain. That's why learning a new
language is associated with a rapid, you
know, decrease in Alzheimer's disease
risk.
>> You're working your brain. You're
learning new things. It's so one of the
worst things that someone can do is
retire
>> and just sit and watch TV, right? I
mean, that's like the worst thing.
You're gonna you're rapidly going to
decline and get dementia.
>> We've got to talk about AI in this
conversation.
>> Oh my gosh. because I actually woke up
this morning and I got a message. Look,
I'll check with him that I can put this
in before I say out before um it's
published. But I got a message from my
chairman, Nikki. Um Nikki is an
incredible man. He's, you know, 25 years
bossing consulting group. He's seen it
all. Um, and he said to me that one of
the things he's thinking a lot about at
the moment is how across our, you know,
businesses, but just generally in
society, how AI is going to impact
critical thinking and what that then
might mean for our teams, our
executives, etc. So, this is a
conversation I was having this morning
with him. And it's also something I've
noticed. There are certain people I
interact with now where I I do not feel
at all like I'm dealing with their
brain. I feel like I'm dealing with what
came out the other end of a chatbt
prompt.
Yes.
>> Good, bad, and different. Like I don't,
you know.
>> Yeah. It's it's an interesting and
important question, Stephen, because
I've been thinking a lot about
what with AI, it's changing so much. And
the question is like, do you focus on,
you know, the negative parts and the
short-term parts? Do you focus on the
potential benefits that could be great
and grand? And I do I do think a lot of
it is people are worried about things
like, oh, AI is going to take all of our
jobs. Oh, we're going to have brain rot
because we don't use our brains anymore.
And and those are concerns to have, but
there's also a lot of exciting things to
think about. I also worry about the the
brain rot part where it's like, well,
okay, these people aren't critically
thinking for themselves. I've seen
comment. I can I can spot AI a million
miles away, a million miles away, right?
And and you know, part of it is if AI is
accurate and they're and people are e
more easily accessing the in accur
accurate information and they're
learning it, that's great. Like that's
what it's supposed to be there for,
right?
>> I think that's a big if, right?
>> If right if and and it does have a lot
to do with the version of AI you're
using. It has a lot to do with the
prompt. It has a lot to do with the
question, how much, you know, reasoning
it has to do. I mean, there's we're it's
still evolving, but I agree. It's kind
of like the worry is are are we going to
have a generation of of people growing
up that don't know how to critically
think.
>> You've heard about that London taxi
driver test experiment. I think I've
heard you talk about it before,
actually.
>> Yeah. I mean, well, they have these maps
in their heads, right? And you have
these taxi drivers in London that um
they don't use GPS. Like, they know
everywhere to go. By the way, I was in
London a couple of years ago. I love the
taxi drivers there. They are so awesome.
Like they are just different. They're
totally different than
>> For anyone that doesn't know, I'm
absolutely going to butcher this. To
become a London taxi driver, you have to
take a test for many, many years. You
have to learn for many, many years, and
you have to learn like every street
across London from the top of your head
without using GPS.
>> So that's incredible.
>> So yeah, when you get in a black cab in
London, it's amazing. You can go, I kind
of want to go to and they go, got you.
>> They know everywhere. They have maps in
their brain. I mean, think about the
cognitive reserve they have. Think about
the like all the things they learned and
what and the spatial memory and all
that. And um do these do these guys ever
get Alzheimer's disease? I don't know
that they do. I mean, there's studies
out there showing that these these types
of um taxi drivers like do not get
Alzheimer's disease.
>> They have to learn 25,000 streets and
it's called the knowledge and they have
physically larger hippocampus centers in
their brain which is the memory center.
And I like to extrapolate if I may and
think that all this cognitive learning
that I do daily and that you're doing by
like talking to guests from all sorts of
fields is also very I mean you're
learning things. It's not just going
you're you're interested in things and
you're learning them and it really is
also a type of brain exercise. And so I
think that this is ultimately what we
were getting to is basically we're gonna
talk about AI because I know we got to
get there but is essentially like if you
can engage in intellectual types of
activities or anything that's going to
exercise your brain whether it's
learning the map of London or it's
learning about mphagy whatever it is you
know it's really good to engage in that
novel learning it's really good for your
brain it's working your brain out
>> I've been thinking a lot about this I've
just come back from South by Southwest
and every conversation was about bloody.
I was there too.
>> I really they were asking me a lot about
AI. So before I went on stage I was
looking at some of the studies and I
concluded that at the moment we are in
society there's going to be a bit of a
bifocation of people. One group is going
to do take the path of least resistance
with AI which is they're going to defer
their thinking to AI which is you know
one of the things I learned from people
like you often is that if you don't use
it you lose it and that part of their
brain whatever it is will begin to
atrophy to some extent. And I think
there'll be another group of people who
will just like we go to the gym now
because we have to because our lives are
so easy. They will go to like the mental
gym which means they will set aside time
to intentionally solve difficult
cognitive problems or or challenges. And
I've I literally have said to some of my
executives, we'll have a moment where
we're talking on WhatsApp or Slack and
I'll literally say, let's try and solve
this problem with our brains because I
believe that solving this problem with
our brains will create a deeper
understanding of the first principles of
the problem. Not the just surface level
1 plus 1 equals 2, but like what is one?
>> What is a number? And this is the
difference like I AI can like give you
the answer, but it's not going to give
you the foundation so that you can solve
other problems in the future. Because if
I never told you what the number one
was, you would never in the future be
able to use it yourself. All you would
know is 1 plus 1 equals 2. But there's
foundations like what are numbers, what
is 1, what is 2, what is plus that you
need to understand to be able to do 1 +
2 equals 3. Um, and the study, one of
the studies I looked at which was has
been heavily discussed was from last
year, I found staggering memory cost
using generative AI. In this study,
which I'll throw up on the screen, 83%
of AI users were unable to remember the
details of a passage of text that they
had written with AI's assistance. EEG
scans showed that brain connectivity was
almost halfed when individuals
outsourced their thinking to AI compared
to writing manually, which created
cognitive debt. You get output faster,
but you don't build the long-term neural
hardware to understand the information
or the knowledge.
>> So true. It's so true. You know what's
interesting about what you just said is
the when you're writing something,
whether you're typing it or even
actually the most I think there's been
some studies on this like handwriting
something,
>> something about handwriting it really
ingrains it into your memory. And I have
this process when I'm trying to there's
a lot of facts that I have to remember,
you know, when I'm talking about them.
And I have this process that I do. And
the first one is the research, right?
you research it and you find it and then
I type it in a Google doc
>> and then I write it
>> and that process is really what gets it
into my memory all the like statistics
and you know think statistics are always
harder because it's just a number
>> you know versus like you like you're
saying you're understanding the
fundamental nature of something that I'm
interested in that always helps and so
it's interesting that if you're if
you're writing something if you're
writing it like typing it or writing it,
handwriting, they're probably talking
about typing it. Even that really does
help you remember something. If you're
just copying it and then trying to do
some recall,
it's not going to it's not going to
work. And then there's the whole other
layer that you were talking about, which
is like you're not even using the
novelty isn't there. You're not like
really into it and learning. And that's
what it really takes to build that
cognitive reserve to improve the
connections to increase brain derived
neurotrophic factor, right? You need
that novelty. So I do love AI, but I
also know that um I need to continue
using my brain and I have my own
protocols that I like and that I still
do. I still write things down. I have a,
you know, I have my little notebook and
I when before I go on a podcast too, I
like to go through and write stuff down
that I've already typed that I've
learned and things I wanted to cover. It
really makes a difference in memory. So
for people that are like you and I and
learners and optimizers, I keep take
take that take that pointer because it
really does work.
>> This was one of my favorite things with
the iPad. Listen, I'm not the type of
person that does a huge amount of
writing on pen and paper. Although I
would do more because everything you've
said is proven to be true for me. If I
write something down, it's like I'm
writing it directly into my brain,
>> right?
>> But the iPad now allows you to split
what you're reading in terms of a book
on one side and then a notepad on the
other. So what I do when I read is I
read the thing and then I try and write
out the lesson on the other side of the
page. So I'll say the gut microbiome has
42 trillion bucks. And I'll go the gut
microbiome has 42 million bucks. I love
it. I love it.
>> And then I turn the page and I I'm so
I'm trying to do exactly what you said
because I realized that a lot of stuff I
learned doesn't land unless
>> right
>> I write it out myself.
>> It's something about the act of writing
>> and if you add the layer of like what I
do it takes time you know so you have to
type it and then write then it really
sticks in your brain. Like those are the
ones when I've done those are the ones
that really have stuck if I've done them
both. But I love that I don't use iPads
ever and I still like read books, you
know, like old books and when I have
time to do them and I just have my
notebook.
>> I think it shows though you you you have
an unbelievable ability to remember so
many things.
>> But I still love AI, you know, I still I
think there's a lot of benefits and I
and I think that, you know, scientists
in general are using a AI is now their
collaborator, right? They're they're
pretty smart collaborator that has
access to a lot of data and can analyze
a lot of data quickly.
>> What are your thoughts on exercise and
the current suggestions and
recommendations around exercise?
>> Well, I'm glad you asked this question.
I think I've been thinking about this a
lot. I did a podcast on the current
exercise guidelines and I think they
need to be updated. I think they're
they're not good enough. And and it's
important for people to realize how
these extra exercise guidelines were
formulated and what they mean. So
typically you'll hear exercise
guidelines 150 to 300 minutes a week of
moderate intensity exercise is good for
optimal health or 75 minutes to 150
minutes a week of vigorous intensity
exercise. Right? So they're basically a
2:1 ratio, right? Twice as many minutes
for for moderate intensity as vigorous
intensity. What is defined as moderate
versus vigorous? That's also important
because it's different across different
studies. In these guidelines, it's
basically moderate intensity is you're
walking. You're moving with intent, but
not really really fast. You're walking.
You're walking at maybe a fast pace, but
you're not jogging, you're not running.
That kind of activity would be
considered moderate. Vigorous would be
considered jogging, running, swimming,
cycling. So the the kind the kind of
activity where you're actually moving
fast with intent.
Why do we have this 2:1 ratio? Where did
it come from? Well, it all came from
energy expenditure. You burn twice as
many calories if you're doing vigorous
intensity exercise as you do if you're
doing moderate intensity. Right? So if
you're walking one mile, you'll burn x
amount of calories. If you jog that
mile, you'll burn twice as many
calories. That's where these guidelines
came from, the 2:1 ratio, right? weight
loss, energy expenditure, but that's not
necessarily what's important for
reducing cancer mortality, reducing
cardiovascular related mortality,
reducing all cause mortality. Right?
These guidelines used that data, this
2:1 ratio of energy expenditure, and
then they looked at other studies and
said, okay, how much exercise is
required to reduce cardiovascular
related mortality or all cause
mortality? And they kind of like
connected the dots. By the way, these
studies also were using um
questionnaires. They weren't actually
measuring how active people were. A new
study came out and I did a journal club
podcast on it because it was a study
that I felt was so important that we
wanted I wanted to break down all the
components of the study with um another
scientist and talk about them because
it's very important. So journal clubs
typically in science you have them in my
career it was you know sometimes it was
once a week other times it was once a
month and and someone you choose a study
that's important and you break it down
and you talk about the results and you
talk about the methods and you talk
about what the findings mean that's what
a journal club is and it's essentially
you choose a a journal and a publication
within that journal and it's a it's a
club you have different scientists that
are talking about it
>> why did this warrant a journal club
>> because I think this study bas basically
is is strong enough data that it's
implying we need to change our exercise
guidelines, at least the messaging of
them at the very least. And I'll tell
you why. Because I talked about these,
you know, these guidelines, how they're
formulated. They're using
questionnaires. They're not measuring
anything. Well, a new study came out.
Not only did it measure physical
activity through these accelerometers,
it was able to measure how active people
were and the type of activity whether it
was I I mentioned moderate versus
vigorous, they also me they also
measured light physical activity that
would be considered walking around your
house kind of doing that kind of light
activity, not necessarily going for a
walk or going for a run. And they looked
at deaths from different causes of
disease. They looked at deaths from all
causes. So all cause mortality, they
looked at cancer related deaths, they
looked at cardiovascular related deaths,
they looked at type2 diabetes, they
looked at heart attacks, right? And what
was so profound was that what we found,
what they found and what we now know is
that everything changes in terms of how
important vigorous intensity exercise
is. It's so much more valuable than we
thought. It's not 2 to one. So if we're
looking at all cause mortality, you
know, dying from all causes, cancer,
respiratory, anything related that's
non-acal,
for every one minute of vigorous
intensity exercise, you had to do 4
minutes of moderate intensity and you
had to do like 100 to 150 minutes of
light exercise to get the same reduction
in all cause mortality.
>> For every one minute,
>> for every one minute of vigorous
intensity exercise, it gets better.
Okay? For every one minute of vigorous
intensity exercise to reduce your death
from cardiovascular disease, you had to
do eight minutes of moderate intensity
and 200 minutes of light exercise. For
every one minute of vigorous intensity
exercise, it's huge. to reduce your type
two diabetes risks. For every one minute
of vigorous, you had to do 10 minutes of
moderate intensity or you had to do
again you're in the 100 150 minutes to
200 minutes of light exercise to reduce
your risk of dying from cancer. For
every one minute of vigorous intensity
exercise, you had to do four minutes
about four minutes of moderate
intensity. And for light, it was like I
it was almost not not even happening. I
mean it was like 250 300 like you had to
just a ton of minutes unbelievable
amount of minutes. Okay. But the the
value of vigorous intensity exercise is
so much more than this 2:1 ratio based
on energy expenditure based on burning
calories that our guidelines were based
on. It's time to rethink them. It's time
to tell people, hey, if you're getting
out and you're going for a run, it is
worth way more than you think it is in
terms of reducing your disease risk and
your death from that disease. Right?
Also, what was really interesting about
this study, and this goes back to this
exercise snacks that we talked about
before last episode, is that because
there people were participants were
wearing these accelerometers on their
wrist, they were able to measure all
physical activity. Let's say you're you
have a new puppy and you're sprinting in
the yard and playing with them for a
minute or two minutes or three minutes
or whatever. Not 30 minutes in the gym,
right? Or not 30 minutes on the
treadmill, but you're just a short burst
or you're playing with your grandkids or
your kids and you're playing tag,
whatever. Those moments count. They
really add up. And that is also a
take-home from this study and other
studies is that you can actually get
massive benefits from the sprinting, the
vigorous exercise. One minute, two
minute, three minutes. Women that did
three and a half minutes of just this
vigorous types of exercise per day
lowered their cancer risk by 40%.
Yes, three and a half minutes a day.
This was in women. Now there's bigger
studies showing men and women that
exercise 9 minutes a day. The short
vigorous types of exercise adding up not
9 minutes altogether, but like a minute
here, a minute there, a minute here,
right? It adds up 40% lower cancer
related mortality, 50% lower
cardiovascular related mortality. And
that's another big takehome from this
study that I really want people to know
about because some people don't like
spending 30 minutes or putting out
blocking out a 30 minute time or an hour
long time to go to the gym. They should.
I mean, if they want their peak span,
that's what you're going to have to do.
But if you're just wanting to avoid
disease and be be your health span, you
know, you can get that by doing these
short moments of short bursts of
physical activity and those count. And
some people are like, "Oh, thank God.
Thank god I can do that because I hate
going to the gym. I'll, you know, they
just won't do it. They won't do it.
>> A lot of people as well are caught up
with this 10,000 steps a day thing.
>> Yes. 10,000 steps a day.
>> What's that facial reaction for people
that can't see your face? She looked up
into the corner like I personally
offended her.
>> Yeah. I look, any exercise is better
than none. I want to just get that on
the table. Okay. That's important. I
don't want to totally diss the 10,000
steps a day, but I think that we need to
ditch it. I think we need to ditch
10,000 steps a day and say 10 minutes a
day. 10 minutes a day of getting your
heart rate up. You can you can you can
do body weight squats. You can, you
know, play tag with your kids or your
grandkids. You can do shorter bursts of
it, but it needs to be 10 minutes. And
if you get to that 10 minutes a day, 50%
lower cardiovascular related mortality,
50% lower all-c cause mortality, 40%
lower cancer mortality. That is what
you're going to get. 10,000 steps a day
is not going to get you that. We just
talked about it. It's not going to get
you that, right? It's a different ratio.
It's not 2 to1 ratio.
>> I imagine there's people thinking you
use three terms there. Vigorous,
moderate, and light. We probably need to
quite clearly define those definitions
like what is vigorous,
>> right?
>> Heart rate is it or
>> vigorous intensity exercise can be heart
rate and it is heart rate. In a lot of
studies that are done in terms of the
exercise guidelines, they don't use
heart rate. They're using movement. Like
when I say accelerometer, I mean moving
fast. So they're able to measure the
acceleration of your movement. And so
the way that they're talking about it in
these in these exercise guidelines
studies is moving fast. Moving fast
would be jogging, running, swimming,
biking. You're moving even
>> stepper.
>> Stepper would would with stepper would
be moving fat. Even even weights are
moving fast. That's part of it too.
Weights you're doing you're doing
weights
>> weight
>> because you're because they're on your
wrist. And so if you're if you're doing
bicep curls or you're doing, you know,
something with your with your wrists
that are fast, it's part of that it's
part of that equation as well.
>> Heart rate isn't the thing that we're
measuring, but that's a consequence of
moving fast. Typically, it is.
>> So you want to be thinking about getting
your heart rate.
>> Personally, when I think about it, and
if I'm talking about in the context of
these exercise guidelines,
I would say that heart vigorous would be
probably considered 70% or more of your
max heart rate would be considered
vigorous. Previously in my when I'm
talking about vigorous I also talk about
highintensity interval training and
that's more like 80% of your max heart
rate or higher very important for
improving V2 max and cardiorespiratory
fitness but in these studies heart rate
was is more like a 70% your max heart
rate and more because that's you can be
jogging at that rate right jogging or
running that's a big that's vigorous
intensity exercise if you're below that
if you're like you know 50% your max
heart rate that's considered moderate
intensity and then you know maybe even
lower than that if you're just sort of
you know walking around the house. I
mean that's not even going out much at
all. That's light. That's considered
light. 10,000 steps would be probably
considered it depends because actually
they're saying steps which means could
just be around the house. If you walk
around your house, how long does it take
to do 10,000 steps? Like an hour, hour
and a half.
>> Yeah, probably just doing six or 7,000
just walking around the office. So, but
that's considered light exercise.
>> So, that's why I think we need to get
rid of that. It's not enough. It's not
enough. It's better than sitting because
sitting is bad. Sitting is an
independent risk factor for disease, for
cancer in particular.
>> This was one of the most replayed
moments last time I spoke to you was
people replayed the section where you
talked about being sedentary and how
much of an issue that is for all of us.
And it's really stayed with me to the to
the fact I don't know if this helps but
I've been using standing desks
everywhere. Even when I travel around
the world now I've actually got a
portable standing desk just to try and
keep me up because as a podcast I I've
sat in this chair for what I've sat down
for six hours today and it's 3 p.m.
>> Right. Yeah. Uh Kelly Starret wrote a
book Deskbound some years ago and you
know he really played a role in
popularizing this this idea and I think
in the public um as well being sedentary
is time you're you're spent sitting
right time you spend sitting it doesn't
necessarily mean I used to think about
being sedentary as oh do you work out
yes or no you're sedentary yes no you're
not sedentary that's not what sedentary
is sedentary is time you're spending
sitting we've been sitting here quite
quite a few course we've been sedentary
this whole time. So being sedentary and
sitting is an independent risk factor.
Even if you're exercising, it's an
independent risk risk factor for
diseases. I mentioned cancer in
particular. That seems seems to be the
one that's more strongly correlated to
being sedentary. But standing standing
helps if you're standing up or also
getting up and doing exercise snacks. So
you can get up every hour and like do
some body weight squats, do some jumping
jacks, do some high knees, get your
heart rate up. That breaks up the
sedentary time. So now it's only an hour
of sedentary versus eight hours, right?
Or six hours or however long you're
sitting at your desk. It makes a
difference. And those exercise snacks
are easy to do. I have a standing desk.
I don't use it enough. I I still have
it. I do do exercise snacks. And I like
doing the exercise snacks because like
literally if we were to get up and do
bodyweight squats right now for one
minute, like you're going to feel
better. You feel better after the blood
flow to your brain. It gives you a
little pump. I love it. I love the pump.
It's it's just one minute of it and you
get a short pump to your brain and it
makes you feel better. So exercise
snacks are a really good way to break up
sedentary time. They're also adding up.
They count as I just mentioned. They
count towards your exercise goal and
they're vigorous. You're you're getting
you're moving fast, right? Vigorous
exercise. You're getting your heart rate
up.
>> Or I could just take a Zen. I just get
the pen out, jab, jab, jab, and it's uh
all of this stuff disappears, right? I
could do all of this stuff or I can just
zen it, right?
>> Yeah. I mean,
>> so many people are taking a Zen. So
interesting. And I listen, I have to say
it's saving people's lives. Amazing.
I've heard so many of my friends who are
on a Zen and taking the GLP1 pens say
that they've had profound benefits.
Their knees are better. They can walk
upstairs. They feel better.
>> Yeah. I mean, let's be real here. Being
obese and overweight is one of the worst
things you can do for your health,
right? It's going to accelerate the
aging process and it's going to increase
the risk of every age related disease.
Cardiovascular disease, type two
diabetes, cancer, you know, visceral
fats happening. You're insulin
resistant. You know, it's all it's all
happening. It's going to affect your
quality of life. It's harder to walk
around. You're not as mobile. Your
joints are getting more stress on them,
right? So, it anything that can help you
lose that weight is going to be
beneficial. And so, these GLP1, you're
talking about ombic, that's the GLP1
receptor agonist, right? They are very
they're life-changing for people that
are obese, people that need to lose, you
know, 40 lb, 50 lb, 30 lb. It's not easy
to lose that weight with diet and
lifestyle.
>> Yeah. Well, let's talk about the butts.
Let's talk about So, the benefits are
obviously if they're going to lose that
fat, the visceral fat, they're going to
become insulin sensitive. They're going
to reduce their risk for all those
diseases. And that's what the data
shows. cardiovascular disease risk goes
down, cancer risk goes down. Um, except
for one type of cancer goes up, kidney
cancer, but you know, the Alzheimer's
disease risk goes down. Anything that
you're going to when you lose weight,
those risks are going to go down. There
are side effects and there are things to
consider when you're taking I'm calling
them GLP-1s because we have first
generation, sec second generation, and
now third generation. And they're
affecting not only the GLP-1 receptor,
but they're affecting glucagon, for
example. they're affecting another
peptide called GIP, GIP. So, I'll just
call them GLP1s for short. Okay. Um,
semiglutide or zic is the f one of the
first generations. We now have the
second generation that's targeting two
pathways. You can lose even more weight.
Marjaro would be something that people
would relate to. That's this one of the
second generation ones. And I think that
for people that are going to start these
these drugs, first of all, they have to
realize there's a good chance they're
going to have to be on them for the rest
of their lives. And that that's
something that you have to be willing to
do. And I say that because
many studies have shown now that
individuals that do take these GLP1s do
lose a lot of weight. And it's very
beneficial to lose that weight. But if
they stop taking the GLP1s, they gain
the weight back and and often oftentimes
they gain all the weight back because
your body's kind of trying to go back to
that reset point and their hunger comes
back with a vengeance. And so part of
what GLP-1 drugs are doing are they are
basically, you know, they're they're
they're making you feel satiated and not
hungry. So they're affecting your
satiety hormone so you don't feel
hungry. They're also slowing gastric
emptying so food stays around in your
intestines longer so you feel full. When
food is in your intestines, you don't
feel hungry. So they're slowing that
process and so people don't feel hungry.
And so what ends up happening is in many
ways it's mimicking calorie restriction
and fasting, right? You're basically not
eating as much food. So that's
essentially but it's doing it for you.
It's not you don't have to put in that
you don't have to feel hungry. You don't
have to put in that work and and it's
doing it for you, right? And so people
are losing a lot of weight and they're
losing it very rapidly. And I said you
might have to be on it for the rest of
your life. And what I what I mean by
that is because a lot of studies show
that majority of people do gain back
their weight. Their appetite comes back.
It comes back with the vengeance and
they they regain the weight over over a
year or so. So that's one thing to
consider. Are you willing to take it for
the rest of your life?
>> There was a a New York Times piece where
they looked at a lady called Stacy
Canterbury. She had lost 50 pounds on
one of the GLP ones that you mentioned,
reaching her peak goal weight. And after
stopping the drug due to insurance
issues, she regained 20 pounds back
straight away in a month. Interestingly,
she described the return of hunger not
as a gradual increase, but as a
ferocious, anim animalistic urge to eat.
That was far more intense than before
she ever started the medication. And the
New York Times did a big piece about
that because one of the things that I've
come to learn is that there's no free
lunch in life. No pun intended.
>> There's no free lunch. There's no free
biological lunch. It's it's true. Um
yeah, people's appetite, that's why I
said it comes back with the vengeance
because it seems to be the case where
your body's like it hasn't been hungry.
And it's like, wait a minute, I've been
starving for so long. I need to eat.
Right? So it's kind of like feed me. And
that's that's obviously something to
consider. So the question is, well, what
happens if you're on these drugs long
term? And you know, we've got these
drugs early early versions of them have
been around. They they also help treat
type two diabetes, right? That's part of
like they where they first came from.
They've been around a while. We do have
some data. Mostly the data is positive
because people are losing a lot of
weight and that is what's putting them
at a high risk for these diseases. And
so when you lose that weight, it what
ends up happening is your disease risk
for all these diseases goes down, right?
So it's hard to uncouple weight loss
from what the drug's doing itself. But
there are side effects in addition to
that, right? Nausea, GI upset, all that
stuff. Maybe temporary. Some people it
kind of sticks around. Some other
effects I think that are are that people
are a little more concerned about are
the um muscle loss and bone loss. That's
a big one. And that is probably
something coming from just rapid weight
loss and and not eating enough food and
not resistance training. So when you're
when you're largely fasting throughout
the day, if you're not getting enough
protein, then your muscle is not going
to have amino acids to help, you know,
basically keep growing. And not only
keep growing, not use its own amino acid
reserve for making protein, right? So
you break down muscle. In fact, there's
weight loss studies showing that in any
weight loss diet, you know, if you're
not eating enough protein and you're not
resistance training, up to 40% of your
weight can come from muscle weight loss
that you're losing. I should say lean
mass, including muscle. So that's a
little different, but it's it's a big
percent, right? And so you're talking
about losing a lot of muscle as well.
And that is something that happens with
these drugs. If people are training,
it's really helps. If they're resistance
training, it's really helping because
that's a signal to to your muscle to
grow muscle. It's a mechanical force
that helps you grow muscle, right?
That's something to consider. Bone loss
is another one. You can also lose bone
from rapid rapid weight loss. I don't
know if there's an independent like
GLP-1 receptors that are on bone doing
something directly there yet to be
uncovered. I think we don't really know
why bone loss occurs. It's thought maybe
it's just the weight loss, but like I
said, maybe there's something that we
don't understand yet. Kidney cancer is
another one. It seems like there's an
increased signal for kidney cancer.
Don't know why that is. Needs to be
studied. There's a blackbox warning on
them for thyroid cancer increase. that's
never really been shown in human
studies. It all comes from animal data,
but it's there nonetheless. Something to
consider
>> and it's very early. So, I feel like
we're going to have a conversation in 5
years time when there's more understood
about these compounds.
>> Well, the the thing that worries me is
that, you know, okay, you have the
person who's 300 lb and like they have
to get down like like that's really
unhealthy, right? It's that can really
be a gamecher for them. But now what
we're seeing is Hollywood. We're seeing
just just your average moms. They're
like, "I want to lose 10 pounds, but I
want it to be easy." Right? They're 10
or 15 pounds, whatever. And they're
going to these JLP1s.
And the question is, I don't know that
we have data showing it's actually
beneficial in that population because
they're already pretty pretty lean and
they're just wanting to look a little
bit better. And we don't really know. We
don't really know if it's beneficial. We
know that losing weight's beneficial for
sure and that's what these drugs are
doing. You're losing a lot of weight
rapidly. The other thing is gallstones.
Um you're getting the increased risk of
gallstones, right? Some people's
gallbladder has to be removed.
>> What about like anorexia and stuff like
that? Cuz I've got a couple of friends
who who are on the pen and they have
they have dropped weight at a speed that
has blown my mind. And part of me is
going stop like stop here. You know, I'm
thinking like I'm thinking, gosh, does
this just keep going down and down and
down and down and down?
>> I don't Yeah, I mean, I don't think it
keeps going down and down and down and
down generally. I think you kind of
stay. You hit a certain point and stay
>> if the dose remains the same.
>> If the dose remains the same. And I
think that people that are already kind
of like at a certain healthy weight
should taper down the dose too, right?
>> Um, and that's also been shown to help
at least with weight regain too. you
want to stop and get off it, you have a
better chance of success if you taper
down the dose and and don't just full
stop, you know, get off of it. Um, it
seems like tapering down helps people at
least slow the weight regain where it's
not happening all of a sudden. Your body
kind of adjust. But I also want to
mention, you know, there are other ways
that you can lose weight, right?
Intermittent fasting. Intermittent
fasting is so on the lowest dose of some
of these drugs like ozic for example if
you're on the lowest dose you can
achieve a similar amount of weight loss
from intermittent fasting as you do from
that and it's not you know if it's five
five you know 5 to 10% body weight not
huge amount but you know for people that
don't need to you lose a huge amount
that's a good way to do it because
you're going to get the metabolic switch
you're going to get the ketosis you're
not going to have to worry about the
side effects you don't have to worry
about regaining the weight because guess
what? You're going to adapt. Your body
adapts. You get used to the fasting
becomes easier. So, I think that, you
know, it it depends on the population
that we're talking about here. Do I have
concerns? Yes, I do. I have concerns.
But do I also think some of these people
that are obese and would never lose that
weight? Is are are they getting a
benefit from these drugs? Absolutely. I
think they are. But it all comes down to
the population who's using them. And
right now, it's become so popular in
everyone. And there's so many people I
don't think need to use it to lose their
10 pounds. It's ridiculous.
>> People take the path of least resistance
though, don't they? And appears to be
the path of least resistance for many.
So, we shall see, I guess. Rhonda, we
have a closing tradition where the last
guest leaves a question for the next,
not knowing who they're leaving it for.
And the question left for you, I think,
is a great one. It is, what is a
purchase that you made that is less than
$100 that improved your quality of life
the most?
That was probably okay. I have two.
Um, I would say the omega-3 index test
that is measuring your omega-3 fatty
acid levels.
>> And you can get that at home or
>> you can order it online and get it at
home. And you do a little you do like a
little spot of blood. It's like a finger
prick blood spot spot. And
just knowing that you're not in that you
want to be 8% range. 8% range is the
5year increased life expectancy. It's
the, you know, 66% lower dementia risk.
I mean, it's really where you want to be
to to be the healthiest. And you might
you might be supplementing with an
omega-3 supplement that's not really
working and you won't know it unless you
do take that test. And I think it's one
of the the easiest ones that I've done.
>> And how did that improve your quality of
life or are you saying it um
>> helped you avoid a bad quality of life?
It's no, I think it's improving my
quality of life because it's it's it's
slowing it's slowing my aging. That's
been shown with omega-3. It's absolutely
slowing aging. I told you omega-3 was
the only supplement that was able to do
that. Um, even in the context of people
that were healthy and physically active.
I mean, this the Swiss these Swiss
people are healthy. It's like if they
did the study in the US, there's no way
88% of them would be physically active.
Not a chance, right? Um, yeah. So, it's
it's slowing the aging process and that
is exactly what I want to do. It's going
to help with peak span. It's going to
help with, you know, health span. It's
going to help with life lifespan as
well. So, and it's it's affordable. It's
less than 100 bucks.
>> And the second one,
>> the second one I think um the one that
really did improve my in quality was a
continuous glucose monitor.
>> Oh, I thought you were going to say
creatine. Okay. Continuous glucose
monitor. No, no, no. You can't go back
now.
>> Yeah, it did. It did because I realized
how important sleep was for my metabolic
health. I thought I was doing everything
right for metabolic health and and it
was it was knowing how not getting
enough sleep was affecting my glucose. I
never would have thought that. Never
would have known. And most people that
get the continuous gluc glucose monitors
never think about that either. They
think about the food they're eating.
They don't think about sleep.
>> And when you get that continuous glucose
monitor, what is it you're looking at to
figure out the connection with sleep?
You can look at first you can look at
your fasting blood glucose levels and
you can go online and for your age and
and gender and figure out what's a
normal range.
>> So that's when you haven't eaten.
>> Yes. Okay. First thing in the morning
and you have not eaten. That would be
the easiest thing to look at.
>> Mhm. And the second thing
>> Yes. The second thing would be to look
at after you eat a meal 30 minutes to an
hour later making sure that you're
clearing that glucose from your meal.
And if you're not seeing that peak come
down and clearing there's something
wrong. Uh,
okay. I might wear another one of those.
It's been a while and they're quite
cheap. You can get them for like $20 on
on the internet. Dr. Ronda, I think
people are going to want to continue to
learn from you. So, where should they go
to learn more from you?
>> I have a podcast called Found My
Fitness. It's on YouTube, Spotify, Apple
Podcast, everywhere you listen to
podcasts. That would be the the best
place. I have a website,
foundmyfitness.com. I have a wonderful
newsletter. Every week we put out
something. We put out one on that
Peakspan paper. We put out a newsletter
on updating the exercise guidelines. I
have a great team. We put out an email
newsletter that's free every single
week. And they're really good. They're
really good in-depth emails so people
can find me there. I'm on social media.
Rhonda Patrick found my fitness. That's
all my that's my my handle, my website
name, my podcast name.
>> I'll link it below for anyone as well
that um would like to go check out that
information. It'll all be in the
description below. I highly recommend. I
mean, I don't really need to tell people
how incredible you are. I think they've
just observed that. So I shant. Um I
shall. You are incredible.
>> Thank you.
>> Um so thank you so much for doing this.
I've learned so much and I've done so
many of these health conversations on
this show and it's almost at a point now
where I'm wondering if there's much more
that I've got to learn. But because I
think you stay at the very cutting edge
of the studies that are coming out and
you're so good at both articulating them
in a simple way that someone like me can
understand even though I can't
understand a lot of the literature as it
comes out of these sort of scientific
journals. I think that you, you know,
you're a person people do need to follow
um because the world and the scientific
understandings are always changing and
it's good to have someone who can
distill that down for you in a way that
is relevant, accessible, and
scientifically rigorous. And that's
exactly sort of the three terms that I
think of when I think of you. So, please
do continue to do the work you're doing
because it's teaching me so much. And by
way of that, it's meaning that I can
live a happier, healthier life. And I
appreciate you for that, Ronda.
>> I really appreciate that. Thank you so
much, Stephen. I love coming and having
discussions with you. They're fun.
>> Thank you. YouTube have this new crazy
algorithm where they know exactly what
video you would like to watch next based
on AI and all of your viewing behavior.
And the algorithm says that this video
is the perfect video for you. It's
different for everybody looking right
now. Check this video out and I bet you
you might love
Ask follow-up questions or revisit key timestamps.
Dr. Rhonda Patrick discusses comprehensive health optimization, beginning with the pervasive impact of endocrine-disrupting chemicals found in everyday items. The conversation delves into the dangers of visceral fat, its causes, and effective strategies for its reduction, including specific dietary choices, sufficient sleep, and targeted exercise. She outlines the concept of "peak span" – maintaining 90% of peak bodily function – and provides recommendations for key supplements like fish oil, vitamin D, and creatine. The discussion also critically examines the limitations of current exercise guidelines, advocating for increased vigorous activity, and explores the potential long-term cognitive impacts of AI usage versus the benefits of active learning.
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