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Anti-Aging Expert: Stop Touching Receipts Immediately! The Fast Way To Shrink Visceral Fat!

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Anti-Aging Expert: Stop Touching Receipts Immediately! The Fast Way To Shrink Visceral Fat!

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4773 segments

0:00

We are being bombarded with disrupting

0:02

chemicals. A lot of them, they're in art

0:04

products.

0:05

>> Okay, let's go to my kitchen. Come with

0:07

me. So, this is my fridge.

0:09

>> So, the first thing I notice is this,

0:10

cuz that's like the worst.

0:11

>> Can I get a bin bag?

0:14

>> This is made from recycled electronics.

0:17

>> What about this?

0:18

>> This is a problem also.

0:21

>> And this?

0:22

>> Ding, ding, ding. This is great.

0:23

>> I'm going to do utensils next.

0:24

>> Heating it up. The plastic is getting

0:26

into your food.

0:27

>> What about a receipt?

0:28

>> That's bad. that's covered with BPA and

0:31

study in adolescent boys showed that it

0:33

was associated with a 50% reduction in

0:36

testosterone. And then this is one that

0:38

people often miss.

0:40

>> The biomedical scientist and anti-aging

0:42

doctor Rhonda Patrick is back.

0:44

>> This time she's talking about health

0:46

optimization, maintaining peak

0:47

performance

0:48

>> and the environmental toxins disrupting

0:50

your body.

0:50

>> Dr. Rhonda Patrick, let's talk about

0:52

something that I've never heard of

0:53

before. Peak span. What the hell is peak

0:55

span? So it's essentially being within

0:58

90% of your peak function. For example,

1:01

muscle mass, bone density that kind of

1:03

peaks around 25 years old and then they

1:06

kind of steadily start to decline.

1:08

>> You're joking.

1:08

>> And the same goes for cognitive

1:09

function.

1:10

>> So I'm on the way down.

1:11

>> Yeah. And I'm definitely on the way

1:12

down. But we can do things in our life

1:14

to help maintain that peak span. Like if

1:16

you exercise 5 hours a week, do some

1:19

highintensity interval training in there

1:20

and you can reverse heart aging by 20

1:22

years. And then sleep very very

1:24

important for preventing your immune

1:26

system from aging rapidly. And then

1:28

another thing that you can do that's

1:29

really important for brain aging is this

1:31

is associated with a rapid decrease in

1:33

Alzheimer's disease risk. But what I

1:35

really want to talk about is

1:36

intermittent fasting supplements and

1:38

being sedentary.

1:39

>> So I want to talk about all of that but

1:41

we've got to talk about this in my hands

1:42

at the moment.

1:43

>> So if you have this it's going to double

1:45

your risk of early mortality.

1:46

>> Double your risk.

1:47

>> Double.

1:48

>> Okay. So talk me through this. I want as

1:49

much detail as possible.

1:51

This is super interesting to me. My team

1:53

given me this report to show me how many

1:54

of you that watch this show subscribe.

1:55

And some of you have told us according

1:57

to this that you are unsubscribed from

1:59

the channel randomly. So favor to ask

2:01

all of you. Please could you check right

2:03

now if you've hit the subscribe button

2:04

if you are a regular view of the show

2:05

and you like what we do here. We're

2:07

approaching quite a significant landmark

2:09

on this show in terms of a subscriber

2:10

number. So, if there was one simple free

2:13

thing that you could do to help us, my

2:14

team, everyone here, to keep this show

2:16

free, to keep it improving year over

2:18

year and week over week, it is just to

2:20

hit that subscribe button and to double

2:22

check if you've hit it. Only thing I'll

2:23

ever ask of you, do we have a deal? If

2:25

you do it, I'll tell you what I'll do.

2:27

I'll make sure every single week, every

2:29

single month, we fight harder and harder

2:31

and harder and harder to bring you the

2:32

guests and conversations that you want

2:33

to hear. I've stayed true to that

2:34

promise since the very beginning of the

2:36

Dio, and I will not let you down. Please

2:39

help us. Really appreciate it. Let's get

2:40

on with the show.

2:45

Dr. Rhonda Patrick, I am fascinated by

2:48

so many of the things that you talked

2:49

about and they're front of mind for me

2:51

at the moment because I'm a 33y old man

2:53

and I know from doing this podcast and

2:56

looking at graphs like this one, which

2:57

we'll talk about today, which I don't

2:59

think most people have ever seen in

3:00

their lives, that this is the age where

3:04

things might start changing direction

3:06

from here on over the next decade. And

3:08

there's things I can do to set myself up

3:10

now if I listen to your advice for the

3:13

remaining decades of my life to be

3:15

remarkably different. I'm playing with

3:17

this in my hands at the moment. It's for

3:19

anyone that can't see, you should

3:20

probably look at the screen right now.

3:21

It's a yellow blob of squidgy, slightly

3:27

disgusting material. What is this and

3:30

why does this matter?

3:33

>> So, this represents visceral fat.

3:37

It's something that most people haven't

3:39

heard of. Many people have heard of fat.

3:42

They know fat is bad, but they don't

3:44

realize there are different kinds of

3:45

fat.

3:46

>> There is visceral fat. And this is the

3:48

kind of fat that you can't really pinch

3:51

atapost tissue kind of fat, right? I

3:53

mean, if you opened up your body, you

3:55

could pinch it because it's deep deep

3:57

within your body. It's often referred to

3:59

as belly fat

4:01

>> and it's it's surrounding your organs

4:03

like your liver, your kidney, you know,

4:06

your intestines. This is a very deep

4:09

belly fat and it's very different from

4:11

subcutaneous fat. You can actually be

4:15

lean but have a high amount of visceral

4:17

fat. We call these metabolically

4:19

unhealthy people. So visceral fat, you

4:22

mentioned you're 33. The average 33 year

4:25

old male has how much visceral fat?

4:28

>> According to the data, it says roughly

4:30

1.2 pounds at the age of 30. And then

4:33

for a woman,.5 lb of visceral fat at the

4:37

age of 30. At 40, it's 1.7 lb for a man

4:41

and.7 for a woman. At 50, 2.2 lb for a

4:44

man, £1 for a woman. And at 60, 2.7 lb

4:48

of visceral fat and 1.54 lb for a woman,

4:53

which is the highest risk for metabolic

4:55

syndromes at that age. But I mean, all

4:57

of them are pretty scary.

4:58

>> It is. And as you notice, the trend is

5:00

as you get older, you have a higher risk

5:01

of having more of it. 70% of women over

5:05

the age of 50 have a high amount of

5:06

visceral fat. 50% of men over the age of

5:08

50 have a high amount of visceral fat.

5:11

This visceral fat, for one, it's going

5:13

to double your risk of early mortality.

5:15

Full stop. That's that's you know it's

5:17

it's going to double your risk. Double

5:19

your risk. Double double. Visceral fat

5:22

is as I mentioned different from the

5:24

other kind of fat. The subcutaneous kind

5:26

of fat the atapost tissue kind of fat

5:29

>> in several ways. One is that it is

5:32

metabolically active. It is secretreting

5:36

inflammatory cytoines. These are, you

5:39

know, molecules that are signaling to

5:41

the immune system, but they're also

5:43

involved with damaging our cells. And

5:46

for this reason, people with a high

5:48

amount of visceral fat are 44% more

5:51

likely to get metastatic cancer. That's

5:54

cancer that's going to metastasize. Very

5:56

dangerous types of cancer. They're also

5:58

more likely, you mentioned metabolic

6:00

syndrome. This is a big big thing with

6:02

visceral fat. This type of fat is

6:06

constantly

6:07

breaking down triglycerides into free

6:10

fatty acids. It's constantly doing it.

6:12

>> What's triglycerides?

6:13

>> Triglycerides are how your body is able

6:16

to store fatty acids and fat and use

6:21

them for later, you know, energy, right?

6:23

So, they're constantly breaking them

6:24

down and using them. They're using these

6:26

these fatty acids. But typically what

6:28

happens in your body when you eat a

6:30

meal, you have your glucose levels go

6:33

up, right? Your blood sugar elevates,

6:35

your glucose levels go up and that

6:37

signals to the pancreas in your body to

6:38

make insulin. Insulin is this hormone

6:41

that plays a role in many things. One of

6:43

it is to tell different parts of the

6:44

body to take gluc glucose up like your

6:46

liver, your muscle, your atapost tissue.

6:49

Well, the problem is is this visceral

6:51

fat is constantly making those free

6:53

fatty acids. And so those fatty acids,

6:56

it doesn't it doesn't respond this this

6:59

we call it it's not really an organ, but

7:01

this type of fat doesn't respond to

7:02

insulin. So whereas the subcutaneous fat

7:05

will stop breaking down fat and using

7:08

fat as energy. It says, "Okay, look, I

7:09

have energy here. I got to do something

7:11

with this energy. Let me let me store it

7:13

for later use." Right? Well, that that

7:16

doesn't happen with visceral fat. What

7:18

happens is it just keeps going, keeps

7:19

going, keeps going. What happens is when

7:22

your visceral fat is metabolically

7:24

active like that, it is basically making

7:27

it where insulin can't work its job. And

7:31

so what happens is that glucose can't go

7:34

into your liver. It stays in your blood

7:36

system.

7:37

>> And you really want it to be stored in

7:38

your liver, right?

7:38

>> You want it to be stored in your liver

7:39

as glycogen to be used as energy when

7:41

you're fasting or when you're, you know,

7:43

physically active or when whenever you

7:45

need it, right? Also in your muscle.

7:47

same thing, stored as glycogen or stored

7:49

in your atapost tissue. Um, and so and

7:51

so none of that happens because insulin,

7:54

it's not able to to basically act on

7:57

your your your organs. It's there's no

7:58

signal. So no, nobody's getting the

8:00

phone call, hey, time to take the

8:02

glucose up. It's not happening, right?

8:03

So the glucose sits around. So what

8:05

happens is your body freaks out because

8:07

it's not good to have glucose sitting

8:09

around in your bloodstream for a while.

8:11

It causes a lot of damage, right? Mhm.

8:13

>> And so what happens is your body makes

8:15

even more insulin to try to

8:17

overcompensate. Your body goes, "Oh,

8:19

maybe that wasn't enough insulin

8:20

because, you know, the glucose isn't

8:22

coming in to the organs like the liver

8:24

like it's supposed to. So, let me put

8:26

some more out."

8:26

>> And for anyone that doesn't know,

8:27

insulin is kind of like the taxi driver

8:29

that goes and picks up the glucose and

8:31

takes it home.

8:32

>> Exactly. It's taking it home. It's

8:33

taking it back to the liver. And so what

8:35

happens when you make more insulin,

8:37

you're overcompensating in such a way

8:39

that now glucose really does get taken

8:42

up into these other organs like the

8:44

liver. And it so much so that it causes

8:48

your blood glucose levels to go down and

8:50

and you're crashing. And all of a

8:52

sudden, this is responsible for that.

8:55

You know, people that eat a meal and

8:57

they're kind of insulin resistant. They

8:58

eat a meal and then all of a sudden

9:00

they're crashing an hour later. We're

9:02

like, why am I why do I have no energy?

9:04

Why am I hungry? Right? Because when

9:06

you're after you crash, your blood

9:08

glucose levels go down. That's what I

9:10

mean by crashing. Um really f far down.

9:13

Not not normal levels, but like below

9:15

that. And so then your body tries to

9:17

overcompensate by going, "Oh, I'm

9:19

hungry. I need to eat." And so you start

9:21

to have these cravings for like energy

9:22

dense foods. And that's part of this

9:25

cycle of the beginnings of insulin

9:27

resistance. And so when I'm talking

9:28

about here with visceral fat, it causes

9:31

insulin resistance. And that's

9:32

essentially the take-home here by by

9:34

it's constantly metabolizing fatty

9:37

acids, it's it's stopping that taxi car

9:40

from going and getting the glucose. It's

9:42

it's not happening. It's not responding.

9:43

You're not picking up the driver, right?

9:45

And so you become insulin resistant. And

9:48

that has a lot of problems. One, it's

9:50

going to affect your immediate energy

9:52

levels. It's going to affect the way

9:53

you're feeling. And two, it's going to

9:56

make you more likely to become type two

9:58

diabetic because eventually your body

10:01

will won't be able to produce enough

10:03

insulin to bring the glucose in. And so

10:05

then you become type 2 diabetic. So that

10:07

is a big consequence of having this

10:09

visceral fat in addition to those

10:12

inflammatory molecules that are being

10:14

generated from this fat. It's just so

10:16

metabolically active. And that

10:18

inflammation that you're generating not

10:19

only does things like raise your cancer

10:21

risk by 44%. It also makes you tired. It

10:25

gives you brain fog, lethargy. When your

10:29

immune system is being activated by this

10:31

inflammation,

10:32

you're taking energy away from your

10:34

brain. It c it's a lot of energy to

10:36

activate your immune system. And so,

10:39

yeah. So, that energy is now going to

10:41

the wrong place. It's not going to your

10:42

brain.

10:43

>> So, you can feel you won't feel

10:44

cognitively as sharp and

10:46

>> absolutely won't just think about when

10:47

you're when you're when you have an

10:48

infection. Your immune system is very

10:50

active. You're fighting off a pathogen,

10:51

right? Do you feel like you're tired or

10:54

do you feel like you're cognitive

10:56

cognitively at your peak?

10:57

>> Uh yeah, I'm like I'm I'm out of out of

10:59

action for several days usually,

11:00

>> right? You're tired and your brain isn't

11:01

working. And part of that reason is

11:03

because your activation of your immune

11:05

system is sucking energy away from your

11:06

brain. And the other reason is because

11:08

the inflammation being generated gets

11:10

into the brain and disrupts

11:12

neurotransmitters and things like that.

11:14

So you're it's like a double whammy.

11:15

You're not your your brain isn't working

11:17

working properly. And so there's a lot

11:19

of people walking around constantly

11:22

feeling tired, feeling lethargic,

11:23

feeling brain fog, and they might have a

11:26

high amount of visceral fat and not even

11:28

know it. So typically,

11:30

>> looking at the data, I mean, most people

11:32

have too much visceral fat.

11:33

>> Most people do have too much visceral

11:35

fat. And typically a really high amount

11:37

is I would say a proxy for it would be

11:41

measuring your waist circumference. So,

11:42

like if women have a waist circumference

11:44

of 35 in or greater, that is a sign of

11:48

too much visceral fat. If men have a

11:50

waist circumference of 40 in or more,

11:52

that is a sign of too much visceral fat.

11:54

Ideally, you would go and get what's

11:55

called a DEXA scan. Now, this is not

11:58

something that's routinely done, and it

11:59

doesn't necessarily have to be done

12:01

unless you're that person that really

12:02

likes to go the extra mile and directly

12:04

measure things. That would be another

12:06

way to do it. You really want to have

12:07

below 300, you know, grams of visceral

12:10

fat. ideally closer to zero the better.

12:12

>> Me and my friend went and got a DEXA

12:14

scan done and the remarkable thing is I

12:17

weigh a lot more than him and I'm much

12:19

bigger than him. He's skinny but after

12:22

the DEXA scan they said that he had too

12:23

much visceral fat which I I thought vis

12:26

I thought you must be like big or obese

12:28

to have visceral fat but he's a skinny

12:30

guy and the DEXA scan said too much

12:32

visceral fat.

12:34

>> Yes, that's the thing. You know, I was

12:36

involved in clinical research for many

12:37

years when I was doing my post-graduate

12:39

training. And we were looking at

12:41

populations of people that were

12:43

metabolically unhealthy or maybe

12:44

overweight, obese in some cases, and you

12:47

would have someone come in that they

12:49

looked skinny, they looked like they

12:51

were metabolically healthy because they

12:53

weren't overweight. And yet all of their

12:56

biomarker data was showing the opposite.

12:58

Like they looked on paper, if you would

13:00

have shown me their metabolic data, I

13:01

would go, "Oh, this is an overweight

13:02

obese person." So these are these are

13:04

lean but metabolically unhealthy people

13:06

and a large percentage of that has to do

13:08

with an increase in visceral fat. You

13:10

won't even necessarily know that you're

13:12

getting higher amounts of v visceral

13:13

fat. It's not necessarily going to be

13:15

reflected on the scale. You know, you

13:17

mentioned maybe a pound, maybe a little

13:18

bit more. That's like daily fluctuation

13:20

in some cases, right? Like I mean I

13:23

don't know about you, but like I I can

13:24

fluctuate a pound from day to day for

13:26

sure. If you're talking about 500 grams

13:28

or less, that's not going to be, you

13:30

know, reflected on a scale either. You

13:32

might be going, well, what why visceral

13:35

fat? What's causing visceral fat? You

13:36

know, I mentioned age, that's a big one.

13:38

Hormones is a big one. Women are very

13:41

susceptible as they go through

13:42

pmenopause and menopause because

13:44

estrogen actually tells helps tell the

13:47

body how to store energy and it tells it

13:50

to store energy and fat in atapost

13:53

tissue, not viscerally. So when your

13:55

estrogen starts to go down during par p

13:57

parmenopause and then menopause, women

14:00

really start to gain a lot of vis this

14:02

belly fat. They gain a lot of the

14:03

visceral fat. Testosterone also it

14:06

doesn't tell the body how to store the

14:08

fat so much. It helps you burn visceral

14:10

fat. So men are a little bit more

14:12

protected when they're younger as well,

14:14

but as they age, of course, testosterone

14:16

goes down as well, and that affects the

14:17

visceral fat. But mostly, it's our diet

14:19

and our lifestyle that's really

14:21

affecting visceral fat. It's kind of

14:24

mind-blowing how quickly you can gain

14:26

visceral fat. Like there was sleep is a

14:29

big one. When you're when you miss

14:31

sleep, that is something that can really

14:33

you can start to store you can start to

14:35

gain visceral fat very quickly. Um there

14:37

was a study in healthy young men. These

14:39

men were sleep restricted. Typically

14:42

when sleep restriction studies are done,

14:43

you're you're looking at four hours of

14:45

sleep per night. So pretty severe. Not

14:48

out of the ordinary. I did many of those

14:50

college graduate school deadlines.

14:52

Definitely as a new parent, I mean it's

14:54

unfortunately drags on for months. So

14:56

these men were only sleeping four hours

14:58

a night for two weeks. Okay, these are

15:00

healthy young men, college age students.

15:02

Okay, young. They gained 11% visceral

15:06

fat after that two weeks, but not a

15:08

pound on the scale, but they had 11%

15:10

higher visceral fat after just, you

15:13

know, two weeks of not getting enough

15:15

sleep.

15:15

>> And they weighed the same

15:17

>> pretty much. So, it was the composition

15:18

of their body that's shifting.

15:20

>> Yes. Also, the visceral fat, like like I

15:22

said, you're not gaining pounds and

15:24

pounds and pounds of it necessarily. You

15:26

know, you're gaining grams and grams,

15:27

but like it's happening and and any

15:30

amount that you're starting to gain is

15:31

unhealthy, right? It's going to start

15:33

causing insulin resistance. It's going

15:34

to start, you know, causing fatty liver.

15:37

That's another thing. It does it because

15:38

it's around the liver. It basically the

15:40

liver doesn't know what to do with all

15:41

the fat. So, it starts to make and store

15:43

it around the fat. And so you start to

15:44

get this non-alcoholic fatty liver which

15:46

is happening now in like young people.

15:48

So sleep is one another major major I

15:51

would say lever for gaining visceral fat

15:53

is your diet quality and quantity. So if

15:58

you start to be in a caloric excess

16:00

constantly you can start to gain

16:02

visceral fat and that's also been shown

16:04

in studies. So, there was a recent study

16:07

that again was in healthy young men

16:09

given about 1,200 extra calories a day

16:12

and it was mostly from ultrarocessed

16:15

foods, right? I mean, they're 1,200

16:17

calories, so like Big Mac and a Coke,

16:19

Big Mac and fries, whatever, you know?

16:21

So, you're you're talking about almost

16:22

like an extra meal a day and from

16:26

processed foods, ultrarocessed foods.

16:28

For 5 days, they were given, you know,

16:30

this extra caloric intake. After that

16:32

five days, they started to gain visceral

16:35

fat. They started to have signs of fatty

16:37

liver after five days. And their brains

16:40

became insulin resistant. And this is

16:42

important. Yes. You

16:44

>> How many calories were they having in

16:45

excess?

16:46

>> 1,200 to,500.

16:47

>> In excess.

16:49

>> More than what they were usually going

16:52

to eat. Yes. Okay.

16:53

>> Yes. So, you know, it's a lot of people

16:56

are eating caloric excess, you know,

16:59

daily. They're not they're not

17:01

exercising and there's no energy

17:03

expenditure and they're eating more and

17:05

so they're in in you know 1,200. Now

17:07

this is the extreme end right I'm giving

17:10

you an extreme end because that's what

17:11

they do usually in in studies like this

17:12

because they want to get a significant

17:14

result but after 5 days they they were

17:17

gaining visceral fat their brains became

17:19

insulin resistant. So insulin is also

17:21

very important for the brain. the brain

17:24

is telling the body how to store the fat

17:26

and how to store energy. And when the

17:28

and when insulin is not able to to get

17:30

into the brain and have its action, then

17:32

you start to not have the brain tell the

17:34

body how to store this energy and it

17:36

ends up storing it viscerally. It's like

17:38

this default.

17:39

>> Do you know putting those two things

17:40

together, the thing I've noticed that

17:42

impacts my performance the most as it

17:44

relates to articulation, cognitive

17:45

performance, my ability to think is

17:47

those two things coming together. You

17:49

talked about sleep and diet. It's when I

17:52

h I eat late

17:55

>> close. It's when I eat close to sleep.

17:57

If I do that a couple of nights in a

17:58

row, I feel like my brain no longer

18:00

works.

18:01

>> Yes. Yeah. You know, obviously we all

18:03

have to like live our lives and there's

18:05

social things and it's fun to go out and

18:06

have a dinner with your friends or an

18:08

event, right? But it's not a good idea

18:12

to eat a meal, a big meal three hours

18:16

before, fewer than three hours before

18:18

bed. So, you want to stop eating 3 hours

18:20

before bed. And three is really the

18:22

magic number in multiple studies because

18:25

when you eat a meal, it is activating

18:27

your sympathetic nervous system, right?

18:30

That's the fight orflight response.

18:33

That's not what you want active when

18:35

you're about to go to bed. When you're

18:36

activating the sympathetic nervous

18:38

system right before you're going to bed,

18:39

let's say you eat a meal within an hour

18:41

of bedtime, you're digesting all that.

18:44

It's your sympathetic nervous system is

18:45

active. And even if you're sleeping,

18:48

it's not good sleep. It's fragmented

18:50

sleep. And so it's disrupted sleep

18:53

because you you need to be in that

18:54

parasympathetic

18:56

part of, you know, the nervous system.

18:59

That dominance needs to be

19:00

parasympathetic, which is the rest

19:03

restore. It's called rest and digest.

19:05

But I don't like digest because actually

19:07

digesting is what activates the

19:08

sympathetic nervous system. So it's like

19:10

the recovery, right?

19:11

>> So should I stay up then for three

19:13

hours? If I if I eat at midnight,

19:16

>> should I stay up till 3:00 a.m.?

19:17

>> No. No. You should just go to bed, but

19:20

don't do it on a daily basis, right? I

19:22

mean, the the key is the habit, you

19:24

know, the habit. And so, if you need to

19:26

eat something before bed, you should do

19:28

something that's light. Maybe a protein

19:30

shake with some almond milk, you know,

19:33

something that's not super heavy.

19:34

>> I've heard you talk about fiber.

19:36

>> Resistant starch does, interestingly,

19:39

seem to help improve sleep. And so, you

19:42

know, maybe some rice or a potato,

19:45

>> a little bit of rice or a potato,

19:46

>> some fries or something.

19:47

>> Maybe not a fried potato, baked baked

19:50

potato and then cool it because then

19:52

it's resistant starch, right? Because

19:53

then it's good for your your gut

19:54

microbiome.

19:55

>> Why?

19:56

>> It changes the composition of the fiber

20:00

>> and and you can cook it, let it cool,

20:02

and then heat it again if you like to

20:03

eat it heated as long as it went through

20:05

a cooling part.

20:06

>> Wow.

20:07

>> And then you can eat it. But that's

20:08

resistant starch. Resistant starch is

20:10

also in green bananas. very beneficial

20:12

for the gut and also for interestingly

20:14

for improving sleep. So things that are

20:17

really moving the needle to to make you

20:19

gain visceral fat or being in basically

20:21

being in a caloric excess especially

20:23

from refined highfat high sugar foods.

20:27

And then not getting enough sleep, move

20:29

the needle. Chronic stress is an

20:32

amplifier of it. So if you're constantly

20:34

having cortisol that's kind of stopping

20:37

the body from storing energy right the

20:39

right way and it's going viscerally as

20:40

well. I would say that amplifies

20:42

especially if it's like in the context

20:44

of being in a caloric excess and not

20:46

exercising. Alcohol is another one. If

20:49

you drink if you're excessively

20:50

consuming alcohol you're going to store

20:52

a lot of the energy that you're also

20:53

consuming is going to be stored

20:54

visceral. I mean you've seen the beer

20:56

belly right? I mean that's like a thing.

20:58

It's visceral fat. It's it's not beer.

21:00

It's visceral fat. So alcohol is another

21:03

one. In terms of losing visceral fat, I

21:06

mean the good news is is that you can

21:08

lose it quite easily and quite rapidly.

21:11

I

21:11

>> was going to say parents have a hard

21:12

time because you're naming those things

21:14

about like sleep and stress and and I

21:17

was thinking gosh parents have like a

21:18

have it coming from them from all sides.

21:20

>> They do. Um the but see this is where

21:22

the good news comes in because you know

21:25

part of the reason why sleep is causing

21:28

you to gain more visceral sleep loss is

21:30

causing you to gain visceral fat is

21:32

because it's causing your body to become

21:34

insulin resistant. It's like this

21:36

vicious cycle. Visceral fat causes

21:38

insulin resistance. Insulin resistance

21:40

causes more visceral fat. Right? And

21:42

becomes this and that's why once you get

21:43

into that cycle it just spirals out of

21:46

control, right? And you start to gain

21:47

more and more and more.

21:48

>> Sorry. Insulin resistance. What is that?

21:50

That is when your body no longer

21:52

produces insulin or

21:54

>> No, no. Insulin resistance is when your

21:57

body is no longer responding to insulin.

22:00

So, it's like it's like you're waiting

22:01

for the phone to ring and it's ringing,

22:03

but you can't hear it, right? Like you

22:06

you're not getting the signal and so

22:08

your your cells are not responding to

22:10

the insulin that's made. Insulin is

22:13

really helping your body bring move the

22:15

glucose out, right? move it move it out

22:17

of your bloodstream where it can cause a

22:19

lot of damage if it sits around

22:21

>> and if you put too much pressure

22:22

pressure on the insulin system then it

22:24

kind of shuts down

22:25

>> eventually shuts down

22:26

>> and the thing that puts too much

22:27

pressure is consuming too much glucose

22:30

or too much activity

22:32

>> too much glucose refined glucose can do

22:35

that visceral fat is one of the I would

22:37

say bigger causes of insulin it's

22:40

actually one of the major major causes

22:41

of insulin resistance because if you are

22:44

physically active and eating a lot of

22:46

glucose, that glucose is going to your

22:48

muscles. Physical activity makes your

22:50

muscles very responsive to glucose

22:52

without needing insulin. Your the

22:54

transporters that transport glucose are

22:56

super super responsive when you

22:59

exercise. That's why physical activity

23:00

and this is what I was getting at with

23:02

parents is so important. The visceral

23:04

fat is the really big like concern with

23:09

insulin resistance. This is and this is

23:11

the thing that again it's like people

23:12

don't even know about it. A lot of

23:14

people are thinking about glucose and

23:15

oh, I got to watch my glucose. And

23:17

that's all fine. I mean, yes, to some

23:19

degree that's also playing a role, but

23:21

it's it's it's the visceral fat that's

23:24

the real underlying problem that's

23:25

that's causing you to become insulin

23:27

resistant. You mentioned parents have it

23:29

like bad because they're stressed out

23:30

and they don't get sleep. I was wearing

23:32

a continuous glucose monitor when I

23:34

became a new mother. I was appalled by

23:37

my fasting blood glucose and by my

23:39

postprandial blood glucose levels. Never

23:41

>> postrenal. Postprandial means after a

23:43

meal. Okay?

23:44

>> So your levels go obviously much higher

23:46

after you eat a meal versus in the

23:47

morning when you haven't had anything to

23:48

eat.

23:49

>> And my levels were were so high. It was

23:52

pre-diabetic

23:53

>> and and I was just I couldn't believe

23:56

it. And it's not like I'm eating, you

23:57

know, drinking Cokes and eating

23:59

terrible, right? But there was a period

24:01

of time when I'm not as physically

24:03

active, particularly in the first couple

24:04

of months. It's really, you know, that's

24:06

the time when you're kind of just in

24:08

this cave. I immediately was looking

24:10

into the scientific literature and found

24:12

that high-intensity interval training

24:13

and exercise can help almost negate most

24:16

of the those poor effects of causing

24:18

insulin resistance and causing your

24:20

glucose regulation to not be normal.

24:23

That's the good news for parents is that

24:25

you should prioritize new parents should

24:26

prioritize exercise and exercise does

24:30

cause you to lose visceral fat. It's not

24:32

just any type of exercise really has to

24:34

be aerobic and the more vigorous the

24:37

better. So for people that don't know

24:38

what that means, aerobic and vigorous.

24:41

>> Yeah. So what I mean is resistance

24:43

training and lifting weights don't

24:46

really move the needle in terms of

24:47

helping you lose visceral fat. It does

24:49

help you improve your metabolism. It

24:52

does help with like glucose, you know,

24:55

sensitivity and all that like because

24:56

your muscles are going to be more

24:57

sensitive to take the glucose in. But if

24:59

you want to lose visceral fat, you're

25:00

going to have to do running, jogging,

25:02

cycling, swimming. You want to like get

25:04

your heart rate up a little more.

25:06

>> Why? It's energy expenditure. It plays a

25:09

role in getting you to that caloric more

25:12

caloric deficit and that's better. So

25:14

that's one way. And the other thing is

25:15

weight any any weight loss program. So

25:17

intermittent fasting, caloric

25:19

restriction, you know, even GLP-1

25:21

receptor agonist and all the classes of

25:24

GLP1, anything that is going to make you

25:26

lose weight, lose fat, visceral fat's

25:29

one of the first to go. And in fact,

25:31

people on on these these weight loss

25:33

programs or even on exercise training

25:35

program, visceral fat's the first fat to

25:37

go and and so you can lose it quite

25:39

quite quickly.

25:41

>> So on this point of fasting, are you a

25:43

fan of fasting to combat visceral fat?

25:46

And also, could you give me your

25:48

thoughts on being in a ketogenic state

25:50

as it relates to visceral fat? Yeah,

25:52

people when they think about

25:53

intermittent fasting, they kind of think

25:56

about,

25:57

you know, one thing and they think about

26:00

weight loss, right? But there's a lot

26:02

going on here. And I like I like that

26:04

you mentioned being in a ketogenic state

26:05

because there's also a metabolic switch

26:06

that happens. This metabolic switch from

26:09

burning carbohydrates and glucose to

26:11

burning fatty acids and getting in

26:13

ketosis, right? That's a metabolic

26:15

switch. And it's very important. There

26:17

are two different things happening here.

26:19

But intermittent fasting is essentially

26:22

a good tool that people can use to

26:24

reduce their calorie intake without

26:26

having to count their calories. That's

26:28

why I like it. You can you can lose

26:30

weight by counting your calories and

26:32

reducing your calorie intake. I

26:34

personally think that's a lot of work.

26:36

Some people love doing it and that's

26:37

great. I think whatever works for a

26:38

person. But the way in which

26:41

intermittent fasting helps people lose

26:42

visceral fat is by reducing calorie

26:45

intake. That's what I'm getting at. It's

26:46

like a tool that some people like to use

26:49

because I like it for one because I can

26:51

not think I just I'll skip one meal

26:54

making sure I get enough nutrients in

26:55

the the meals that I eat and protein in

26:57

the meals I eat. But I'll skip a meal

26:59

and it gets me in a caloric deficit

27:01

without having to think about and count

27:03

everything. So it's easier on me

27:05

>> to fast

27:06

>> to fast versus counting calories.

27:08

>> And how how do you do that? So, I like

27:11

to fast in the morning. And the reason I

27:13

like to fast in the morning is for the

27:15

exact reason you mentioned, and that is

27:17

the ketosis, which I like to call the

27:19

metabolic switch. You're not eating

27:21

while you're sleeping, obviously. So, if

27:22

you're sleeping for 8, if you're in bed

27:24

for 9 hours, 10 hours, you're not eating

27:26

during that time. And it takes about 10

27:30

to 12 hours for your liver to deplete

27:34

glycogen. glucose that's been taken up

27:36

by the liver is stored as glycogen so

27:38

that you can then use it for energy

27:40

later if you don't have energy coming

27:42

in. Right.

27:42

>> So the glycogen is like the the petrol

27:44

station.

27:44

>> Yes.

27:45

>> So it runs out of petrol.

27:46

>> That's right. And and so um it takes

27:49

>> it switches to diesel.

27:49

>> And it switches to diesel. And so after

27:51

that switch, that metabolic switch when

27:53

you deplete that glycogen while you're

27:55

sleeping or while you're not, you know,

27:57

not eating after about 12 hours. And by

27:58

the way, this is all relative because it

28:01

depends on the kind of foods you eat and

28:03

how physically active you are. So, if

28:05

you eat a lot of high carbohydrate,

28:07

refined sugar stuff, you might take even

28:09

longer to deplete your glycogen because

28:11

you're you're putting a lot of input in

28:12

there. You keep filling up the the fuel

28:14

tank, right?

28:15

>> But if you're eating things that are

28:17

more low carb, you might deplete your

28:19

glycogen sooner. So, when you deplete

28:21

your glycogen, you get into this

28:22

metabolic switch because your body still

28:24

needs energy, but there's no nothing, no

28:26

glucose around, right? So, you start to

28:28

switch to, you know, your fatty acids

28:30

are mobilized. They come out of your

28:31

atapost tissue. This is why people lose

28:33

fat. They come out of the visceral fat.

28:35

You you start to use those fatty acids

28:37

and burn them as energy. And as a

28:38

product of that energy, you're making

28:40

ketones, ketosis. And the reason I like

28:43

to do this in the morning is because

28:44

then I can really get into that ketoic

28:46

state where if I'm fasting, I do it

28:49

typically I fast for about 16 hours a

28:51

day and then I eat my meals within eight

28:53

hours a day. Typically, that's my what I

28:56

do. The reason I like to be in that

28:57

metabolic switch state is many reasons

29:00

actually. One, the ketones themselves

29:03

are providing my brain with energy, very

29:07

e easily utilizable energy, but they're

29:10

also acting as a signaling molecule to

29:12

my brain going, "Hey, this is a

29:14

stressful time. There's no food. You

29:16

better be cognitively sharp. You got to

29:18

find that food. You got to like know

29:19

what you're doing, right? It's an

29:20

evolutionary adaptation." You know,

29:23

humans for thousands of years were going

29:25

through this metabolic switch because we

29:26

didn't have Instacart. We didn't have

29:27

Postmates. We didn't have all Uber Eats,

29:29

right? We had to find our food. We had

29:31

to hunt our food. And we always didn't

29:33

always do that, right? And so when I get

29:36

into that metabolic switch state, I feel

29:39

it. I feel more cognitively sharp. And I

29:43

feel less anxious, which is part of it

29:45

because those ketones also help increase

29:48

something called GABA. That's an

29:49

inhibitory neurotransmitter. It's

29:52

essentially, you can just think of it as

29:53

like it helps you feel calmer. When I

29:55

feel calmer, I'm more cognitively

29:58

focused because it's like the background

30:00

anxiety is down, right? It it's like you

30:03

can focus. And so, I love being in that

30:06

state in the morning because that's when

30:07

I get my work done. I also like to be in

30:09

that metabolic switch state. And this is

30:11

why I like fasting in addition to, you

30:13

know, the calorie, the fewer calories

30:14

I'm consuming, right? Your body has to

30:16

be in that fasted state to repair. If

30:19

you're constantly in a fed state, fed

30:20

states are important for anabolic

30:22

growth. We need it to grow, right? But

30:24

the repair state is also very important

30:26

because with the growth comes damage.

30:29

Damage comes along with that and you

30:31

want to repair that damage because

30:32

damage will accelerate aging. And so I

30:34

like to be and give my body enough time.

30:37

I don't want to just wake up and eat

30:39

where it's like, oh, I've only barely

30:41

depleted my liver glycogen. I'm not even

30:43

in that repair state very long, right? I

30:45

want to extend it a little bit. And so I

30:47

like to have that repair process active

30:49

and that it is active during it's

30:52

fasting activates it but also you have

30:55

some amount of active repair going on

30:56

even when you're in a fed state. It's

30:58

just heightened when you're fasted. So

31:00

those are the reasons I like to be I

31:03

like intermittent fasting. I feel good

31:05

when I do it. I also do a lot of

31:06

training, not all of it. I do a lot of

31:08

training fasted. Cardiovascular aerobic

31:12

endurance exercise. So running, biking,

31:14

that stuff I like to do fasted. I'm not

31:16

going for a 10-mi run. I'm going for a

31:18

three- mile run, right? I mean, this is

31:20

So, if I was going for a 10 mile run, I

31:22

wouldn't be fasted. I would need some

31:24

fuel. But there are studies, me,

31:27

multiple studies showing that if you do

31:29

aerobic endurance training, this kind of

31:31

running, cycling, swimming type of

31:33

training, you actually have better

31:35

adaptations if you're fasted versus fed.

31:37

>> What does that mean? So much of the

31:40

benefit from exercise, right? Aerobic

31:42

exercise when you're breathing in,

31:44

you're you're you're you're right,

31:46

you're working hard is from the working

31:48

hard, but your body responds to that,

31:51

right? Because the working hard is

31:52

causing inflammation. It's causing

31:54

oxidative damage. And your body is

31:56

responding to that by going, "Oh, we got

31:58

to get better at this stuff." So, you

31:59

have anti-inflammatory pathways

32:01

activated. You have antioxidant pathways

32:03

activated. Your body needs to burn fat.

32:05

You need fuel. And so if you're fasted,

32:08

you get better at burning the fat and

32:10

oxidizing the fat and you continue to do

32:12

that throughout the day better as well.

32:13

So you have what are called

32:14

mitochondrial adaptations that are

32:16

better. You make more mitochondria.

32:18

Mitochondria are very important little

32:21

tiny organels inside of most of our

32:23

cells that make energy and they, you

32:26

know, they're very important for

32:27

everything. I mean, they're running our

32:30

brains right now so we can talk, our

32:32

heart, you know, so we can breathe, our

32:34

lungs, everything, right? And so

32:35

exercise does make you increase the

32:38

amount of those new mitochondria that

32:40

you make that are young and healthy.

32:41

>> If you're fasted

32:42

>> both, even if you're not, but if you're

32:44

fasted, it's even better.

32:46

>> This has been a big debate around

32:48

whether this applies to both men and

32:49

women.

32:50

>> Should both men and women exercise

32:52

fasted?

32:53

>> This is my read of the literature and my

32:56

thoughts on this from also having

32:58

experts that have studied male versus

32:59

female responses to exercise. First and

33:03

foremost, how do you feel when you

33:05

exercise fasted? If you feel terrible,

33:08

that's a sign. I think listening to your

33:11

body is the most important thing that

33:13

you can do. There are times when I have

33:15

to eat before I exercise and I listen to

33:18

my body. I that's it. I'm I'm going to

33:20

eat. When it comes to women versus men

33:22

and doing exercise fasted, it also

33:24

depends on are you again, are you doing

33:26

a 30 minute run? Are you doing a 2hour

33:29

run? If you're doing a 2-hour run, you

33:31

need to fuel. That's a lot. That's a big

33:33

stress. When it comes to a 30-minute

33:36

run, you don't really necessarily need

33:38

to. Now, the problem with women is that

33:40

they're often if you're in too much of a

33:42

caloric deficit and you don't eat enough

33:45

food within, you know, like afterwards,

33:46

you're not refueling enough and you're

33:48

doing very very long high volume types

33:51

of exercise, then you can basically

33:54

disrupt your, you know, some of your

33:56

hormones, your your follicle stimulating

33:58

hormone, luteinizing hormone. These

33:59

things will make you become amenoretic.

34:02

So you basically stop ovulating and you

34:05

stop getting your menstrual period.

34:06

>> And what's the evolutionary reason for

34:08

that? What's going on?

34:09

>> Because your body's like there's not

34:10

enough food and energy around to sustain

34:13

a ba, you know, a growing fetus like

34:16

they're growing shutting down.

34:17

>> So it's so it's basically like, hey,

34:18

we're not going to allow you to have a

34:20

baby basically. So you stop you stop

34:22

ovulating, right? So you can't you're

34:24

not making you're not making those eggs.

34:26

Is this often the case with women who

34:28

exercise a lot and no longer have their

34:29

menstrual cycle?

34:30

>> First of all, this is not a common

34:31

thing. This is like this is something

34:33

that happens in, you know, like

34:36

athletes, elite athlete, women that are

34:38

not eating enough food. Like I I did

34:41

this to myself when I was in my early

34:43

20s and I was running I was racing

34:45

marathons and I was running 10 miles a

34:47

day, you know, eight to 10 miles a day,

34:49

five days a week and then I was eating

34:51

carrots and hummus and you know, I just

34:54

I wasn't fueling myself and I did I did

34:57

this to myself, too. So, how do you feel

34:59

if you train fasted? Do you feel

35:01

terrible? Don't do it. If you want to

35:03

train somewhat fasted, go for the

35:05

protein, you know, protein shake with a

35:08

little bit of almond milk or something

35:09

like that where you're not eating a full

35:11

meal, but you're getting something. So,

35:13

I do a lot of my training fasted and

35:16

that has helped me. You know, I'm 47

35:18

years old and penmenopause.

35:21

>> You're in phenomenal shape.

35:22

>> Thank you. Thank you. Um, but I did

35:25

notice, of course, as as I started to

35:27

reach that pmenopause part of my life

35:30

that I had to be a little bit more

35:32

aggressive and put a little bit more

35:34

effort in to not get this fat right here

35:37

on my belly cuz it started coming up and

35:40

I didn't want it. I didn't it wasn't it

35:41

wasn't an option for me. Speaking of uh

35:43

studies done for women, you I've heard

35:46

you talk in the past about the Swan

35:47

study, which kind of relates to what you

35:48

just said there. Um when relating to

35:51

women in visceral fat, and they found

35:52

that women experience an accelerated

35:54

increase in visceral fat starting 2

35:55

years before their final menstrual

35:57

period.

35:58

>> Yeah. Because that's when their estrogen

35:59

is about it's just it's plummeting,

36:01

right? You're just going off a cliff

36:03

because you're you're about to go into

36:04

menopause.

36:05

>> Again, what age would that be? Average

36:07

age of menopause is between 50 about 50

36:10

52 for women. A lot of that there's a

36:13

lot of things that can affect your

36:16

reproductive lifespan, your ovarian

36:18

aging I guess we can call it. And

36:22

unfortunately, one of them is when you

36:24

the age you were when you got your

36:25

menstrual period. So the younger you

36:27

were, the younger you're going to be

36:30

when you experienced menopause. So also

36:32

when your mother experienced menopause

36:34

is very very indicative of when you're

36:36

going to experience it. But lifestyle

36:38

and diet play a role too. Obesity

36:41

accelerates ovarian aging. So you're

36:43

more likely to go into menopause earlier

36:44

with obesity. Also these chemicals that

36:48

we're exposed to and we can talk about

36:50

those as well. A lot of these endocrine

36:52

disrupting chemicals affect the age of

36:55

menopause as well and and accelerate

36:56

that. So some in some cases women go

36:58

into menopause two years earlier than

37:00

they would have otherwise.

37:01

>> And you're so you're 47

37:03

>> Mhm. and a half

37:04

>> and a half. And the data that I'm

37:06

looking at here says when we think about

37:08

permenopause, it usually starts in

37:09

mid-40s, which is the age range you're

37:11

in. This is where the 8 to 10% annual

37:15

visceral fat increase begins.

37:16

>> It is. And and I

37:19

>> Yeah. I can tell you from people in my

37:21

life that I've seen going through this,

37:24

it's pretty sudden that you'll see

37:26

someone in your life that's a woman

37:28

that's going through Mary Pen Perry

37:30

menopause and maybe hasn't had any other

37:32

symptoms yet, so they haven't really see

37:35

any treatment. Now, you can you can try

37:37

to do some hormone replacement therapy

37:38

as well to help with that, but they

37:41

start to gain visceral fat and it shows

37:42

up around the belly quite rapidly. And I

37:46

noticed this in myself. It almost feels

37:49

overnight. Seriously, this is the only

37:50

symptom that I noticed in myself where

37:53

it was like all of a sudden my belly was

37:56

like growing and um you know, not super

38:00

super large, but enough where I was like

38:02

there's something wrong. It's not even

38:03

necessarily reflected if you get hormone

38:05

tests cuz mine all seemed normal. The

38:07

thing is is that the estrogen when it

38:09

drops that estrogen is so important for

38:12

telling your body to store energy

38:14

differently, not around the organs, but

38:17

to make it around, you know, other parts

38:18

of your body like your your thighs and

38:20

your butt, right? Like your atapost

38:22

tissue. And so when that estrogen goes

38:24

down and declines, it's like boom, it

38:27

starts to go right to the belly. So that

38:30

is why for me intermittent fasting has

38:32

been really important. Like with any

38:35

weight loss or calorie restriction

38:38

protocol, you do need to make sure

38:40

you're getting enough protein because

38:41

that's important for muscle, right?

38:43

Muscle growth and preventing atrophy of

38:46

your muscle. And you need to also do

38:48

resistance training. That also is a very

38:50

important signal for muscle. Because the

38:52

problem is some people calorie restrict

38:54

and eat fewer meals and then they're not

38:56

getting enough protein and they're not

38:57

training and they start to lose muscle

38:58

in addition to fat and you don't want to

39:00

do that. You want to kind of just lose

39:01

the visceral fat and keep the muscle

39:03

ideally keep gaining muscle.

39:05

>> And for men, I was reading that

39:06

testosterone and growth hormone

39:08

typically peak in their late 20s. So I

39:10

guess mine's peaked already. Um and

39:12

starting at age 30, testosterone drops

39:14

roughly 1% a year. So between the age of

39:16

25 and 65, men typically see a 200%

39:20

increase in their visceral fat even if

39:22

their total weight stays the same. So

39:28

is that linked into testosterone

39:29

decline? Is that what's going on there?

39:30

What's causing it?

39:31

>> Yeah, I mean it's it's testosterone does

39:33

you burn even if you're gaining visceral

39:35

fat, it helps you burn it. It's it's

39:37

also why some women that are in

39:38

pmenopause want to do testosterone

39:40

because it helps them burn the visceral

39:42

fat. M um so it is it is linked to

39:44

testosterone decline as well but also as

39:47

men are aging their they become more

39:49

sedentary they send they tend to eat a

39:51

little bit they're consuming more

39:52

calorie like all these things are

39:53

handinand so it's like a it's not just

39:55

like a one punch right it's like

39:57

multiple angles are kind of all

39:58

compounding and coming together whereas

40:00

you could get away with it a little bit

40:01

easier when you're younger because the

40:02

testosterone was helping you burn it

40:04

more

40:05

>> when you're declining it doesn't it

40:07

doesn't work that same way so even

40:09

though you're gaining it you're not

40:10

burning it as quickly so you start to

40:12

have a net gain in it. Uh if that makes

40:15

sense.

40:15

>> So going back up to the top then we were

40:17

talking about things you can do to lower

40:18

your visceral fat and we talked a little

40:20

bit about exercise, sleep, diet. Is

40:22

there anything else in that category?

40:24

>> Yeah, I think those are the main ones.

40:26

Obviously avoiding excess alcohol

40:27

consumption. Yeah.

40:28

>> And also

40:30

>> stress. Stress.

40:31

>> Yeah. Yeah.

40:31

>> The stress like you know trying to to

40:35

relaxation techniques buffer that

40:37

stress. That's a big one. It's an

40:39

amplifier.

40:40

>> Yeah. People don't talk enough about

40:41

visceral fat, you know, they look at

40:44

other markers.

40:45

>> No. Well, most people just want to lose

40:47

weight and look good.

40:48

>> Yeah.

40:48

>> Or Yeah. They look at, you know, HBA1C,

40:51

your long-term glucose, or they're

40:52

looking at lipids, and visceral fat is

40:55

just it's it's insidious, right? It just

40:57

starts increasing, increasing,

40:58

increasing. You can't see it. You can't

41:00

see until all of a sudden belly, right?

41:03

I mean, it's it's it's bad. And it

41:04

affects the way you feel daily. On this

41:07

point of testosterone, why is it the

41:09

case that testosterone seems to be

41:11

dropping amongst men? I think it said

41:13

something like I wrote it down. Yeah,

41:15

testosterone levels in men have dropped

41:17

by up to 20% over the last two decades.

41:21

>> Um, which is quite terrifying.

41:25

>> It is. So, look, there's a lot of

41:29

factors that can affect testosterone. I

41:31

mentioned dietary factors, refined

41:33

sugar, sleep is a big one. people aren't

41:35

getting enough sleep, lack of sleep

41:37

drops testosterone, micronutrients, not

41:39

getting enough zinc, for example, zinc's

41:41

very important for testosterone

41:42

synthesis and magnesium. Like there's a

41:45

there's there's important nutrient

41:46

components, but I think the big player

41:49

here is actually environmental. I think

41:52

that

41:53

we are being bombarded with what are

41:57

called endocrine disrupting chemicals.

42:00

These are man-made chemicals. A lot of

42:03

them are part of plastic. They're made

42:07

to help plastic be more durable or more

42:10

robust or they're found or they're water

42:13

resistant. So there's probably three

42:16

main endocrine disrupting chemicals that

42:19

are found in our environment mainly

42:21

because they're in plastic or they're in

42:24

they're also in things that are water

42:25

resistant, oil resistant, fire

42:27

resistant, flame retardant. BPA

42:29

bisphenol AA is one. Another one is

42:32

phalates. PH phalates. And the last one

42:36

would be PAS. These are the forever

42:38

chemicals. These are the three main I

42:41

would say players in terms of disrupting

42:45

endocrine function. Endocrine being

42:47

hormones. Sex hormones like

42:49

testosterone, estrogen, but also thyroid

42:51

hormone. Very important for regulating

42:52

our metabolism for example.

42:54

>> Are they really causing a problem?

42:57

>> Absolutely.

42:58

>> Really? Like

42:58

>> absolutely. cuz I'm looking at the

43:00

picture you have there of Pa Pas

43:03

>> PAS

43:04

>> PAS and it's got like a coat and shoes

43:06

on there. You're telling me my the

43:07

clothes that I wear are having an impact

43:09

on my hormones.

43:10

>> They can, but I think it's it's it's

43:14

less of a direct effect and more

43:15

downstream. So the the the PAS chemicals

43:18

or the forever chemicals, they're used

43:20

in things to make them oil resistant,

43:22

stain resistant, water resistant. So the

43:24

teflon pans would be the biggest

43:26

example. You remember those non-stick

43:28

pans? They have teflon that has PAS on

43:31

it.

43:32

>> We're going to go into my kitchen in a

43:33

second. So, I'll take all of the viewers

43:34

that are watching now into my kitchen.

43:36

We'll have a stroller around my kitchen.

43:37

You let me know if there's some things.

43:38

>> Oh gosh, I hope you don't have Teflon.

43:39

But, I mean, my mom used it when I was,

43:41

you know, growing up. I remember the

43:42

non-stick pans that stuff is coming off

43:45

into your food and so you're eating the

43:47

these PAS.

43:48

>> How do we know that they're dangerous?

43:50

>> Okay. Well, I'll tell you how we know.

43:52

like let's let's start with so the PAS

43:55

chemicals are ones that are really

43:56

they're more affecting the thyroid and

44:00

they're affecting I would say ovarian

44:02

aging they seem to target the ovaries

44:04

and accelerate the age that you're going

44:06

to get menopause so you're going to get

44:08

it around two one to two years earlier

44:10

if you have a high amount of these

44:11

forever chemicals but there's been

44:13

studies a lot of studies looking at

44:14

let's start with BPA okay bispenol A

44:18

that's a big one because you see a lot

44:19

of marketing around BPA free. This

44:22

plastic water bottle is BPA free. Well,

44:25

it's BPA free, but it has another

44:27

chemical called BPS, which is very

44:29

similar, if not worse, than BPA. So, BPA

44:32

is something that's found in a lot of

44:33

water bottles. It's in those plastic

44:35

water bottles. It lines the cups of uh

44:38

paper cups, like these to-go coffee cups

44:41

that you're getting at your favorite,

44:42

you know, coffee place. Plastic is

44:45

lining them. Yes, plastic lines them

44:47

because it's protecting it from the

44:49

liquid, right? BPA has been linked to

44:52

many different diseases, but really

44:54

really it's an endocrine disruptor. So

44:56

what it does is a couple of things. One,

44:59

BPA acts as an estrogen mimemetic. So it

45:02

kind of mimics estrogen and it binds to

45:05

the receptors that estrogen do to do its

45:08

function. And so it sometimes binds to

45:10

estrogen and either makes it seem like

45:12

there's estrogen around or it blocks

45:14

estrogen from working. So it's it it

45:16

depends on the dose and the

45:18

concentration. So it can do both, but it

45:20

also binds to androgen receptors that

45:23

interact with testosterone, right? And

45:25

so there have been studies that have

45:26

found that men that have high amounts of

45:29

BPA also have low amounts of

45:31

testosterone. That there was also a

45:33

study done in teens. This is when you

45:36

know your sexual development is

45:38

happening, right? Testosterone is very

45:39

important during this part of of your

45:41

life during puberty. Teens, adoles, ad

45:44

adolescent boys that had the highest

45:46

amount of BPA

45:48

had 50% lower testosterone than men than

45:52

the boys, sorry, that had the lowest

45:54

amount of BPA. The biggest one that's

45:56

affecting testosterone is the phalates.

45:59

These phalates, they are present in a

46:02

lot of PVC piping. They're present in a

46:05

lot of our food packaging. all those

46:06

like thin art or you go to the you know

46:09

to the grocery store and you get a filet

46:11

manon steak and it's wrapped in plastic

46:13

poultry all that plastic wrapping and

46:16

all the foods that we're eating has

46:18

phalates in them that make it more

46:20

flexible and stuff and it's also found

46:22

in our hair products our cosmetic

46:24

products our creams and it's also very

46:27

lipid

46:29

soluble it likes fat it is drawn to fat

46:32

so when you have plastic around fat like

46:34

cheese you know things like fat meat.

46:37

It's getting into that meat. It's

46:39

getting into that cheese, the phalates.

46:41

These disrupt our hormones in ways

46:44

similar to BPA. So, they're binding to

46:47

the androgen receptor, but they're also

46:50

going into the testes and disrupting the

46:52

synthesis of testosterone. So, there was

46:54

a study in men that had the highest

46:56

phalate levels, those men had 20% lower

46:59

testosterone compared to men with higher

47:02

levels. And

47:03

>> and this is Yeah. And this is like it's

47:06

affecting not only just the

47:07

testosterone, but it's affecting sperm

47:09

quality. So the shape of the sperm

47:11

wasn't good. It's affecting the number.

47:14

So sperm count is down if they're higher

47:18

BPA or higher phalates. And also um

47:21

motility, the the ability to swim.

47:23

Pregnant women that get exposed to high

47:25

levels of phalates and if they have if

47:27

they're carrying a a male fetus, right,

47:29

they they're having a boy. What's been

47:32

shown is it's also affecting sexual

47:34

development. So these boys, they're

47:37

getting something called hypospadia.

47:39

That's where like this the slit on the

47:41

ur on the um on the penis is like moved

47:44

backwards kind of closer to like what a

47:45

a woman would have. And they're getting

47:47

undescended testicles. So one of their

47:49

testicles is not descending. And that's

47:51

associated with you know infertility,

47:53

cancer, testicular cancer being the big

47:54

one. This is happening at a alarming

47:58

rate. like something like 20% of boys

48:00

now have an undescented testicle. I

48:03

mean, it's crazy

48:05

>> because their mother had high phalates.

48:07

>> Well, it's this is definitely something

48:10

that is known in our environment to

48:12

cause that. I don't know if that's the

48:13

only cause, but it in my opinion is a

48:16

very very concerning cause that nobody

48:19

is talking about and that should be

48:20

addressed. And it's everywhere. We have

48:22

these in all of our all of our plastic

48:24

wrappers that we everything that we're

48:26

eating. you know, you you even getting

48:28

your meat, you're you think it's well,

48:30

it's meat. It's, you know, but it's

48:32

wrapped in plastic and that phalates are

48:33

getting into the food. So, they're

48:35

getting into our bodies and they're

48:37

disrupting hormones. They're disrupting

48:39

sexual development. They're disrupting

48:41

our ovaries, estrogen, you know, ovarian

48:44

aging, age of menopause. They're

48:46

disrupting thyroids, the thyroid

48:48

hormones. I mean, there's there's even

48:50

studies now with women, pregnant women

48:52

that have high levels of BPA.

48:55

they have they're six times more likely

48:58

to have a child with autism spectrum

49:00

disorder compared to women with low

49:03

levels of BPA. Again, BPA is disrupting

49:08

the estrogen and androgen receptor. And

49:11

this is very important because

49:13

the androgen you you want to have it's

49:16

it's disrupting aromatase as well, that

49:19

enzyme that's involved in converting

49:21

testosterone into estrogen. So,

49:25

believe it or not, when you're a boy

49:27

developing in your mom's womb, estrogen

49:30

plays a very important role in your

49:32

brain and brain development and what's

49:34

called masculinizing the male brain. You

49:37

actually, it's kind of contradictory.

49:38

You're like, "Oh, well, wouldn't

49:39

testosterone do that?" Well, actually,

49:41

estrogen is very important for

49:42

masculinizing parts of the male brain.

49:44

And so when you have aromatase being

49:46

inhibited by bisphenol A by this

49:49

endocrine disrupting hormone that is so

49:51

ubiquitous everywhere

49:52

>> that is found in plastic bottles

49:53

>> plastic bottles it's it's found in yeah

49:56

it's found everywhere.

49:57

>> So what what do you recommend?

49:59

>> First of all I think if you can uh

50:01

eliminate and not drink out of plastic

50:03

bottles as much as possible. If you do

50:05

want to go coffee either drink it there

50:07

in their mugs or bring your own to- go

50:10

mug. Like I bring my like I have like a

50:11

Yeti kind of to- go coffee mug that I'll

50:14

bring into a Starbucks or wherever

50:16

coffee bean and I'll have them fill it

50:18

up. Soup cans canned soup are lined with

50:21

BPA. They're lined with plastic and soup

50:24

usually goes into the can hot sterile

50:27

technique. I mean they they want to make

50:29

sure it's so you're getting the soup has

50:31

been classically shown in multiple

50:33

studies to me to to increase BPA levels

50:35

by a thousand%.

50:37

Crazy amounts. So, don't eat canned soup

50:40

as much as possible. I mean, obviously,

50:42

this is about the habit, not the

50:43

one-off, but but you know, try to avoid

50:46

cans, drinking out of even soda cans,

50:49

even like your your favorite sparkling

50:50

water cans. Don't make it a daily habit

50:53

because they are lined with plastic.

50:55

That's a source of BPA into your bodies.

50:57

There are ways that you can excrete BPA.

51:00

So, the major way to get rid of it is

51:02

through urine. It's excreted through

51:03

your urine, but it has to become water

51:06

soluble first. It's a fats soluble

51:08

compound. And so there are things that

51:12

we can eat in our diet that will

51:14

increase that excretion. Compounds in

51:17

broccoli. Broccoli sprouts being the big

51:18

one. Sulurophane activates a pathway

51:21

that are enzymes involved in making BPA

51:24

become water soluble. So they come out

51:26

your urine.

51:26

>> Oh, so broccoli is like a cleanser.

51:28

>> It's like a cleanser. It's like we we

51:29

actually do have these it's called phase

51:31

2 detoxification enzymes in our body. We

51:34

have the ability to detox a lot of

51:36

things. We just have to give our body

51:38

the right, you know, input so that it

51:40

can activate those pathways. I

51:42

personally take a supplement of that

51:43

sulfurophane because I want a

51:45

concentrated amount of it because I used

51:47

to do broccoli sprouts. Broccoli sprouts

51:48

have a hundred times more sulfurophane

51:50

than mature broccoli, but you have to

51:52

sprout them and then there's

51:53

contamination issues and it's just, you

51:55

know, some people do it. It's great, but

51:57

I used to do it. I don't anymore. I just

51:58

take a supplement.

51:59

>> That supplement's called

52:00

>> The supplement I take has is called

52:02

Avacol. It's by a company called

52:04

Neutramax. I don't um you know I'm not

52:07

like affiliated with them. I like their

52:09

supplement because one they've got 12

52:11

published studies using it. Clinical

52:13

studies too showing that it actually

52:15

helps with um autism children and

52:18

adolescence with autism that take the

52:20

sulfurophane supplement that they have

52:21

improved symptoms because it's a detox.

52:23

It helps interestingly people with

52:25

autism are like 30 times less likely to

52:28

excrete BPA. It's a weird thing going on

52:31

here where BPA increases autism spectrum

52:35

disorder, but then kids that have it are

52:37

not able to detoxify it as well.

52:38

>> Wow.

52:39

>> Yeah, it's interesting. Again, I think

52:41

that excretion is important, but

52:43

avoiding avoiding the plastic as much as

52:45

you can. Make it a habit. Don't freak

52:46

out. I mean, obviously you can like make

52:48

yourself crazy and stress is not good.

52:50

As we talked about, I see you like

52:52

going, "Oh my god."

52:53

>> Yeah. Know, I'm thinking about just how

52:54

casual I am about these things, though.

52:56

And I could I could easily make small

52:58

changes. I I could frankly I could easy

53:00

make big changes in the position I'm in.

53:01

I could just say I can say in my company

53:03

we no longer buy this kind of stuff. I

53:05

could say in my kitchen cuz you know to

53:07

my team or whatever. Let's not buy this.

53:09

Can we go look at my kitchen now?

53:10

>> Let's do it. Let's go. Let's go to my

53:12

kitchen. Be right. No, you guys can come

53:13

too. So we're going to go to my kitchen.

53:15

If you're Listen, if you're listening on

53:17

the dog walk, this might be a nice time

53:18

to sit on a bench and look because

53:20

you're about to go into my kitchen and

53:21

we're going to look at real things that

53:23

you might not even know in your kitchen

53:24

are causing you some of these problems.

53:26

Come with me. You know, the little

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traditional SIM card that goes inside of

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our phones, they haven't changed at all

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since they were invented in the '90s.

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You have this physical piece of plastic

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that means you're locked into one

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carrier, one network, and the second you

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cross a border, that carrier can start

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55:29

Okay, so the team have been here for the

55:31

last couple of days. We've been getting

55:32

lots of takeaways. And so this is a

55:33

higgled piggledy of everybody's food.

55:35

What's wrong? You got you're pulling

55:37

>> black plastic.

55:38

>> What's wrong with the black plastic?

55:40

>> Um, we talked about plastic. It has BPA.

55:42

It has phalates, but it also typically

55:44

is made from recycled electronics. And

55:46

the problem here, Stephen, is recycled

55:49

electronics have flame retardants in

55:50

them because you don't want your

55:51

electronics catching fire. And there

55:53

have been a variety of studies now that

55:55

have found that black plastic has a high

55:57

amount of these flame retardants that

55:58

are leeching into the food and getting

55:59

into people's bodies that way. Not only

56:02

do you not want to eat out of black

56:04

plastic, you don't want hot food going

56:05

in there, right? Cuz that's like the

56:07

worst.

56:07

>> Can I get a bin bag? I need a bin bag.

56:09

Okay. Okay. So, let's throw that in the

56:11

bin. What else? I'm going to take all of

56:14

it out.

56:14

>> Okay. This is the other thing that

56:16

really reaches out. Stands out to me

56:18

because

56:20

spicy foods, anything acidic that goes

56:23

into plastic causes the chemicals to

56:25

leech into it even more rapidly. Kind of

56:27

the same way the heat does. So, heat,

56:30

acidic foods, not good in plastic.

56:33

>> So, my spicy sauce, if it comes in a

56:35

little plastic tub, it's going to leech

56:36

in.

56:37

>> Look, if it's the oneoff, okay, but like

56:40

not a habit. Yes. A big time leech in

56:42

it. You're you're you're eating BPA hot

56:44

sauce.

56:46

>> Okay. So, the black stuff is out and

56:49

>> it's going in hot.

56:51

>> Yeah, this has phalates and had BPA. I

56:54

mean, look, are you drinking this every

56:55

day or is it the oneoff?

56:56

>> No comment. No comment. Mind your

56:58

business. Okay. What else? What about

57:01

this?

57:02

>> This is made of paper.

57:03

>> Here's my little thing I do. See that

57:07

waxy? There's a waxy

57:10

>> a pas

57:11

>> on the edge.

57:12

>> Yeah. Does it seem like it has a waxy

57:14

substance to you?

57:14

>> Yes.

57:16

>> This is This is better than the black

57:17

plastic. If you had to like if there's

57:19

like tears, this is better than black

57:21

plastic.

57:21

>> Okay. And this

57:23

>> ding ding ding. This is great. This is

57:25

the best thing that you can do if you're

57:27

going to have food made for you or you

57:28

want to order takeout, have someone make

57:29

it for you and deliver you in this.

57:30

>> And this is a bamboo lid.

57:32

>> Bamboo lid with with GL Pyrex glass,

57:35

right?

57:36

>> Okay. So, this is what this is good.

57:37

>> This is great.

57:38

>> So, I need more of this.

57:39

>> You need more of this and get rid of all

57:41

I mean, this is already looking better.

57:43

This is on the scale. At least it goes

57:45

in cold. So, here's the thing.

57:47

Microplastics are also shedding into

57:49

this. We didn't talk about

57:50

microplastics. They're shutting into

57:51

here. the chemicals, not as much in

57:55

something like this, but they're still

57:56

getting in. So, this is a little bit

57:58

better when it comes to like the the

58:01

tears here. The hot food is the worst.

58:03

This is a little bit better, but I still

58:04

would get lettuce

58:05

>> because it's cold.

58:06

>> Because it's cold.

58:07

>> So, it's not seeping.

58:08

>> Exactly.

58:08

>> Okay. So, I might be able to keep that

58:10

then. What else do you notice here?

58:11

>> So, I noticed that I really like your

58:13

glass sparkling waters. That's great

58:15

because, you know, glass is is less

58:19

likely to have microplastic shedding,

58:20

less likely to have the chemicals.

58:22

>> There was a study that actually found,

58:24

interestingly, there were more

58:26

microlastics in on the top. So, the

58:30

paint that's on these lids, plastic

58:33

polymers are used in that. And during

58:35

the processing and, you know, bottling

58:36

up of these things, they get into the

58:38

the the water. And so, believe it or

58:40

not, glass bottled water has more

58:43

microlastics than plastic bottled water.

58:46

Okay, this is terrible. But I'm going to

58:49

tell you why I think this still is

58:50

worse. Okay, so this is got

58:53

microplastics, but it also has BPA and

58:55

phalates. They're in this water. This

58:57

was not always cold. It's, you know, it

58:59

was some warehouse shipping container.

59:02

Who knows how it got here? It's been

59:03

heated up, I'm sure, several times. The

59:06

problem is is that there was a study

59:07

showing that glass bottles have a higher

59:08

amount of microlastics than than

59:11

plastic. And you might go, why is that?

59:13

Because they're all coming off on this

59:14

paint and getting in. When it comes to

59:16

microplastics, size matter. I'm not as

59:18

worried about it having more

59:20

microplastics because it would show that

59:21

they were large microplastics. Your body

59:24

doesn't absorb a large ones very well.

59:25

They come out through your feces. These

59:28

This has tons of what are called

59:29

nanoplastics, very, very small particles

59:32

that get into the gut and get into your

59:33

bloodstream. So, I still go for the

59:35

glass water. So, I would avoid drinking

59:37

out of these as much as possible. So, I

59:40

like how you have these condiments in

59:42

the glass. This is how my refrigerator

59:43

looks as well. I'm very, very obsessive

59:46

about anything that has acidity in it,

59:48

like hot sauce and ketchup. It needs to

59:50

be in glass because the acidity is

59:52

leeching microplastics and BPA and

59:54

phalate chemicals into your condiments

59:57

and then you're putting that on your

59:58

food and you're eating them. Again, this

59:59

is ubiquitous. It's everywhere. Plastic

60:01

is everywhere. The chemicals are

60:02

everywhere. And you're not even thinking

60:04

about the fact that your hot sauce and

60:05

ketchup are also, you know, vehicles for

60:08

delivering these microplastics and, you

60:10

know, their associated chemicals into

60:11

your body. So, I really like these.

60:14

Like this one, I would go for a glass

60:16

mustard. Those those are better.

60:18

>> Glass bottle. So, this is plastic. Same

60:20

thing. It's acidic. I would say um you

60:23

know, for the most part, the butter. Oh,

60:25

yeah. This is bad. Is this butter? Oh,

60:28

cheese. Yeah. So, this is a problem

60:29

also. So if you look at this um it's

60:32

that flexible plasticky stuff, right? It

60:34

has phalates in it.

60:35

>> Well, this this

60:36

>> Oh, that's even worse. This is Yeah. So

60:39

this is the plastic that basically, you

60:42

know, phalates are in this and they're

60:45

fat soluble and they are just leeching

60:47

into this fatty cheese. They're leeching

60:49

into the fatty cheese. So you can buy

60:51

cheese that's like without this in just

60:54

the container that's a little bit

60:55

better.

60:56

>> You know what I mean? Like like I'm

60:57

thinking of feta cheese for example.

60:59

Like some feta cheese comes in this

61:00

plastic wrapper, but you can buy it with

61:02

just the container and at least it's not

61:04

like close like with juices like just

61:07

seeping into it, you know, getting the

61:09

chemicals into it.

61:10

>> Ah, but this is fine, isn't it?

61:13

>> Eggs.

61:14

>> Yes, eggs are great.

61:15

>> There we go.

61:15

>> Eggs are great.

61:16

>> We found something.

61:19

Okay, Vonda. So, spatulas and kitchen

61:22

utensils. Are these good? Are these bad?

61:25

What's What's the best?

61:26

>> Yeah, good question. These are great,

61:28

right? Okay. There's no plastic here. No

61:30

possibility of plastic leaking into your

61:32

foods. You got your nice pasta spoon.

61:34

These are silicon, I'm imagining. Um,

61:37

>> in theory, the silicon should be okay.

61:41

Um, the problem is is that there's a lot

61:43

of silicon that actually still has it's

61:46

mixed with plastic, too. So, I go for

61:48

the wood ones that are like this, like

61:50

the wooden spatula. That's what I use.

61:53

You in theory should be good. In

61:55

practice, a lot of silicone that's been

61:57

measured out there and tested does have

62:00

plastic. So, I would say if you want to

62:03

really be careful, I would switch.

62:06

>> But most people at home probably have a

62:08

plastic spatula. Is that accurate?

62:10

>> Most people at home have plastic spatula

62:13

and a lot of people also have black

62:15

plastic spatulas, which again back to

62:17

that black recycled electronics, flame

62:19

retardants, these are cancer-causing

62:21

chemicals in there. Bromelated chemicals

62:23

that are causing cancer. So yeah, I

62:24

would say that even shifting from the

62:26

plastic to this is probably a step up,

62:29

but I don't know that this is just pure

62:32

silicon. I I I I would guess that

62:34

there's some plastic still in it. And so

62:35

if you're heating it up, the plastic,

62:37

it's getting into your food.

62:38

>> Okay. What about um my my pans? So what

62:41

about Got my pans here.

62:44

>> Great. All clad. This is what I use.

62:46

These are amazing.

62:48

No plastic lining, no PAS, no nonstick.

62:52

So, most people's pans at home have a

62:55

sort of a protective layer here that's

62:58

nonstick so that they can cook their

62:59

food and their food doesn't stick to the

63:02

pans. Like scrambled eggs, they're kind

63:03

of a pain in the butt if they stick to

63:04

everything. That has the forever

63:06

chemicals in them and that is being

63:08

heated up and is leeching into your food

63:10

and you're eating it. So, really what

63:12

you want to avoid the most is uh Teflon,

63:16

right? Anything that's nonstick.

63:18

>> It's harder to cook with these though.

63:19

>> It's so much harder. But you know what?

63:21

you're healthier and that's what you

63:22

have to imagine.

63:23

>> The other thing I want to talk to you

63:24

about is this.

63:26

>> The blender.

63:28

>> Ah, yes. The blender. This is one that

63:31

people often miss. The problem is most

63:33

blender

63:35

tops here that's blending your stuff is

63:37

plastic. And there are studies showing

63:39

that when you have a lot of friction on

63:42

plastic, that releases orders of

63:44

magnitude more microlastics. And of

63:46

course, their associated chemicals are

63:47

hitchhiking along there. There are

63:49

companies that make a stainless steel

63:52

version of the blender, and I highly

63:54

recommend if you're someone like myself,

63:56

I like to do my kale blueberry

63:58

smoothies, that you switch to the

64:00

stainless steel. I did. I switched for

64:02

my family. Um because essentially the

64:04

friction, you're drinking microplastics

64:06

and chemicals. So that's bad.

64:10

>> A receipt.

64:11

>> Yeah, don't touch it.

64:12

>> What What do you mean don't touch it?

64:13

>> Um so receipts are

64:15

>> Why are you touching it like that?

64:17

covered with BPA. I mean, literally just

64:20

covered. That's how it prints it, right?

64:22

This isn't like a printer. This is

64:24

printed. It's a thermal paper and and

64:27

the BPA is allowing the printing to

64:29

happen. And so, they're covered with

64:30

bisphenol A. People that are handling

64:33

receipts, like cashiers that are

64:34

handling receipts, have really high

64:36

levels of BPA. Um, particularly if they

64:38

use like hand sanitizing lotion or any

64:41

lotion, any sort of cream makes the BPA.

64:44

Again, BPA is fat soluble. these creams

64:46

um the hand sanitizers are carrying it

64:48

inside to your inside your bloodream

64:51

about a hundfold higher than not having

64:53

that. So, first of all, you can opt to

64:55

have an receipt emailed to you if you

64:57

need the receipt. I would do that or,

65:00

you know, don't touch it. But also, if

65:02

you work in the cash, if you're a

65:04

cashier and you work in this industry,

65:06

really, really, please wear nitrial

65:09

gloves. I mean, this is like your BPA

65:11

levels. If you were to go get them

65:12

measured, which you can, there are

65:13

companies out there now that do measure

65:15

BPA levels in urine, you will see that

65:17

they are extremely extremely high. So,

65:19

um, nitro gloves will protect you from

65:21

from the BPA getting across your your

65:24

dermal barrier and getting to your

65:26

bloodstream. Uh, latex gloves do not.

65:28

So, make sure they're nitro gloves. And

65:30

for people that are not in the industry,

65:32

try to avoid the receipts. I mean, it's

65:34

a really big exposure to BPA that people

65:36

aren't even realizing.

65:37

>> I can tell by the way you're like

65:38

grabbing the corner of it like it's

65:39

feces or something.

65:40

>> Oh, it's terrible. And my son, like, you

65:42

know, kids love paper. And of course I

65:44

don't want them touching it because we

65:45

talked about that study in adolescent

65:46

boys where they had high BPA levels and

65:48

that was associated with a 50% reduction

65:51

in testosterone. I mean this is at a

65:52

part of your life when testosterone is

65:55

you know important for sexual

65:57

development and development in general.

65:58

So really really really important to

66:00

remember receipts are a very big source

66:03

of BPA that people are not thinking

66:05

about particularly people that are

66:07

routinely handling these receipts. And

66:09

um the other thing I want to talk you to

66:11

you about is water.

66:14

So here is one of my water filters. I

66:16

also have a filter attached to the tap.

66:18

What are your thoughts?

66:20

>> So this is filtering water, but it's

66:22

filtering it into plastic and it's also

66:24

got plastic filter.

66:26

>> So I think that you know you're probably

66:28

filtering away some other things,

66:29

pathogens, gross other chemicals that

66:31

might be in the water, but you're

66:32

essentially reintroducing the plastic.

66:34

So I don't know that that's necessarily

66:36

the best way to get the filter. What you

66:38

have over here is a reverse osmosis

66:40

water filter. That is absolutely the

66:43

ideal reverse osmosis water filters

66:46

filter out microplastics, nanoplastics,

66:48

BPA, phalates, chemicals, all these

66:51

things that we're talking about today.

66:53

People can get a tabletop one kind of

66:55

like this is tabletop, but it's a

66:57

tabletop reverse osmosis water filter.

66:59

These only filter out the bigger, larger

67:01

plastic size, microplastic size. And

67:03

then the last thing I want to mention,

67:04

Stephen, because you do have a reverse

67:06

osmosis water filter, is that it does

67:08

filter out a lot of small particles,

67:11

including essential, you know, trace

67:13

elements and some essential like

67:16

minerals and stuff. So, you want to make

67:17

sure that you are taking a multivitamin

67:19

mineral supplement. And you can also get

67:21

what's called little essential um

67:23

element drops that have things like

67:26

phosphorus, maganese, iodine, some of

67:28

these things that are being filtered out

67:30

of your water and making sure you're

67:32

reintroducing that to your water.

67:33

>> H Okay. So, it takes some good stuff out

67:35

too.

67:35

>> It does. Yeah.

67:36

>> Okay. Is there anything else that maybe

67:39

is either in my kitchen now or not in my

67:41

kitchen that is a culprit of BPAs and

67:44

pouls?

67:45

>> Yeah. Here's the first problem here. And

67:47

then inside where the hot water is going

67:49

through is there's plastic pieces. So

67:52

the hot water is going through plastic

67:54

to get to your little espresso, you

67:56

know, cup here. These I actually looked

67:59

into this cuz at first I thought they

68:00

were lined with plastic. They're not. My

68:02

concern is mostly the water going

68:04

through the system that's heating up.

68:06

It's going it's got plastic, you know,

68:08

piping in there that it's going through.

68:10

>> Okay. So I'm going to just stay there

68:11

and I'm going to just grab

68:15

Okay. So this is now the coffee that I

68:18

drink called contier.

68:20

>> Um they flash freeze it at the perfect

68:22

moment and it's delivered frozen. So

68:23

metal and then this is an aluminum lid,

68:26

>> right? So it shouldn't be lined with

68:27

plastic, right?

68:28

>> You go like this, press the little

68:30

button on top and it goes straight into

68:32

your glass and then this

68:34

comes out and that's the coffee.

68:37

>> Oh, I love it.

68:38

>> So you just drop It's funny cuz they're

68:40

a sponsor.

68:40

>> Oh, should disclaimer and I'm also an

68:43

investor in this company. So, um, no no

68:46

machines at all. Put it straight into

68:47

the glass, pour the hot water in, and

68:48

that's it.

68:49

>> So, it's like in instead of instant co

68:50

It's like instant coffee, but it's real

68:52

coffee that's been frozen.

68:53

>> It's from some Stanford engineers who

68:55

flash freeze it at the perfect moment to

68:56

lock in the taste. And you can literally

68:58

smell

68:59

>> Smells good.

68:59

>> Smells good. Yeah. Um,

69:00

>> yeah. I'm so glad you're not putting it

69:02

in a machine cuz that's

69:03

>> No, no longer do that. Okay. So, this is

69:06

my supplement cupboard. It's a It's a

69:07

mess, but I've pulled out things that I

69:08

that I'm personally interested in, good,

69:10

bad, indifferent. The first one that

69:12

jumped out at me when I was looking is

69:14

reduced and active glutathione.

69:17

This is something that um I think people

69:19

should be aware of. There's marketing

69:21

involved here. Glutathione is in a major

69:23

it's a major antioxidant. We make it in

69:25

our body. We make it in our brain.

69:27

>> What does it do? Sorry.

69:28

>> So, it's a very important antioxidant.

69:30

It helps negate oxidation which is

69:32

causing brain aging. It's it's negating

69:34

oxidation which is aging yourself.

69:36

Right. M

69:37

>> people want to supplement with it

69:38

because they've heard about glutathione

69:40

and how beneficial it is and how it's a

69:41

great antioxidant. The problem is

69:43

because our body makes it inside of our

69:45

cells inside of our cells. We don't have

69:47

a transporter to get glutathione from

69:50

the outside of our cells like if we eat

69:51

it and if it makes it through our

69:53

digestion, which it really doesn't, into

69:55

our cells. And so this kind of

69:57

glutathione isn't going to make it

69:58

inside of your cells.

69:59

>> So this is just a waste of time. It

70:01

>> it is. You're going to want to get

70:03

something called liposomal glutathione.

70:05

Liposal glutathione has been shown to

70:07

get inside because liposomes it's

70:10

essentially taking the glutathione

70:11

molecule and encapsulating it in

70:13

something that's going to fuse with your

70:15

cell. Liposal products in general have a

70:18

higher bioavailability for that reason.

70:20

>> So let me repeat that back to you. So

70:22

I've got it. So if it's liposal, it's

70:24

basically in a packet which can get

70:25

through into the cell. If it's not, this

70:27

one is um reduced and active. Then it's

70:30

never going to get in the cell. So it's

70:31

waste of time. It's just going to be

70:32

excreted. Yeah, I would say that it's

70:34

really not doing much and that if you're

70:35

going to want to supplement with liposal

70:37

glutathione, that's what I have.

70:38

>> What about this vitamin D3? I've always

70:41

been confused because people say take

70:42

vitamin D, but then this one says D3,

70:45

>> right? D3 is the form of vitamin D that

70:47

you make when you're in the sun. That's

70:49

the major way we make vitamin D is from

70:51

sun exposure. There is a plant form of

70:54

vitamin D called vitamin D2. It's found

70:56

in things like mushrooms, for example.

70:59

The problem is is that there have been

71:01

studies showing that vitamin D2, which

71:03

is unfortunately what a lot of

71:04

vegetarians take because they want a

71:06

vegetarian form. Vitamin D3 is also

71:09

found in like sheep skin because the

71:11

sheep are making it in their, you know,

71:12

skin when they're exposed to sunlight.

71:14

Um, vitamin D2 is not as effective as

71:17

vitamin D3. If you are a vegetarian or a

71:19

vegan, you're going to want to look for

71:21

vitamin D3 from lychen. Lyken is that

71:24

like green stuff that you can find on

71:25

trees and stuff that also makes vitamin

71:28

D3 and so it's a it's a much better

71:31

option than getting the vitamin D2 which

71:32

is what a lot of vegetarians do. So

71:34

there's actually a a study, recent study

71:36

showing that people that are vitamin D

71:38

deficient, so they're not getting enough

71:40

vitamin D3 because we don't go out in

71:41

the sun anymore. They have accelerated

71:43

aging. And if they supplement, this is a

71:45

very large study, by the way, if they

71:47

supplemented with vitamin D3, they

71:49

slowed their their biological aging by

71:51

almost 2 years. That didn't happen in

71:53

people that were not vitamin D deficient

71:55

from the start. So it's not like a

71:57

vitamin D3 supplement is going to do

71:58

something miraculous if you already have

72:00

enough vitamin D. The the point is to

72:02

avoid deficiency and so you know someone

72:05

like yourself that does probably doesn't

72:06

go outside a lot but also well you go

72:08

outside but you're not you have darker

72:10

skin so melanin is a natural sunscreen

72:12

and so people with more melanin have to

72:14

spend a lot more time in the sun and so

72:16

that is something to consider as well.

72:18

Well, I can always just take my

72:19

multivitamin,

72:20

>> right? Multivitamin. I think I might

72:22

have talked about one study last time we

72:24

talked last episode where men and women

72:27

that were older adults, they were 65

72:29

years and older, they took one

72:30

sententrum silver a day. And I'm not,

72:32

you know, I'm not advocating for

72:34

sententrum silver. I'm just saying that

72:35

was involved in the study. And um after

72:38

3 years, they had reversed their brain

72:40

aging, global brain aging by 2.1 years.

72:43

And they reversed their episodic brain

72:46

aging by almost 5 years. So episodic

72:48

memory is the kind of memory involved in

72:51

remembering events and people and things

72:53

like that you know as you get older you

72:55

know that stuff doesn't come as quick

72:57

right so it delayed that aging by 5

72:59

years well this same study also um just

73:02

recently published literally like a

73:04

couple of weeks ago again part of this

73:07

large study it's called the Cosmos study

73:09

they looked at the multivitamin use and

73:12

biological aging epigenetic aging and

73:14

they found that the Centrum silver

73:16

multivitamin also slowed slowed

73:18

biological aging, epigenetic aging by a

73:20

few months and this was only after two

73:21

years and you might go oh a few months

73:23

but that was after two years and that

73:25

that trial was two years long. So if you

73:27

add two two years and then you add

73:29

another two years and then you add and

73:30

then you're talking about 20 talking

73:31

about 30 talking about 50 years that is

73:34

slowing aging the entire time. It adds

73:36

up. It's cumulative and it's one of the

73:38

easiest things that someone can do to

73:40

basically you know make sure that

73:42

they're aging better. There's things

73:44

that are harder to do, but that to me is

73:46

such a lowhanging fruit. It's easy.

73:48

>> What is it about this? What is in here

73:50

that's making a male multivitamin have

73:52

such profound effects?

73:53

>> If you look at the back at the the

73:55

supplement facts, there's a lot of

73:56

vitamins and minerals. Things like

73:58

vitamin C, vitamin D3, vitamin E,

74:00

vitamin K, nascin, the B vitamins,

74:03

folate. You have things like selenium,

74:05

the essential those essential elements.

74:07

These are all things that we need to run

74:11

everything in our body. All of our

74:13

metabolism, our neurotransmitter

74:14

synthesis, our immune system, you know,

74:17

our our liver, all these these these are

74:19

co-actors that are really important for

74:20

all those things. And you don't realize

74:22

how important they are until time goes

74:24

on and things start to fall apart. It's

74:26

basically filling the gaps because we're

74:28

supposed to get this these things from

74:30

our foods. We're supposed to be getting

74:31

all these vitamins and minerals from our

74:33

foods, from from our water, and it's

74:35

just not happening for many reasons.

74:36

One, our soils are depleted. You know,

74:38

the organo phosphates like glyphosate is

74:40

depleting our minerals. And so the foods

74:42

that are being grown in the soil aren't

74:44

getting their minerals that they're

74:45

supposed to. And then the second problem

74:47

is we're not eating the right foods

74:48

because we're taking we're eating

74:49

takeout. We're eating foods that are not

74:51

micronutrientdense. Things like dark

74:53

leafy greens. We're not eating the

74:55

colors of the rainbow. And those are

74:56

really important for vitamins and

74:58

minerals.

74:58

>> So I've got two questions there. Is

75:00

there a multivitamin that I could take

75:03

that is not good for me? Because when I

75:05

go to the shops, there's so many

75:06

different types these days and I don't

75:08

know which one's good, bad or how to

75:10

tell the difference. And so honestly,

75:11

sometimes I just go based on the most

75:13

expensive because I assume the most

75:14

expensive is the best quality.

75:15

>> Yeah. So, you know, the problem with

75:18

supplements is they're not regulated. I

75:20

mean, not that I necessarily want them,

75:22

but it is a problem because supplement

75:24

companies can kind of put whatever they

75:26

want in the supplements. They don't

75:27

necessarily have the amount of active

75:30

ingredient that they say or they can

75:32

either have too little or too much. And

75:34

so that is the problem with

75:35

>> too much.

75:36

>> Yeah. So for example, some vitamin D3

75:39

supplements and some um melatonin

75:42

supplements have like some in some cases

75:45

like a,000 to 10,000fold more. And it

75:48

was a really big problem with melatonin

75:50

because melatonin is that hormone that

75:52

you make to help you fall asleep and

75:53

there was excessive amounts in them. So

75:56

it's not regulated. So that you really

75:58

don't know the amount you're getting.

75:59

So, I would say number one, go to a

76:02

trust trusted brand that is thirdparty

76:04

testing. There's so much thirdparty

76:06

testing now. Consumer lab does it. You

76:08

can, you know, look up what they've

76:09

tested. But for a man, I would say the

76:12

thing that's essential here is you don't

76:13

want to get iron. You don't want

76:16

supplemental iron.

76:17

>> Well, someone told me to start drinking

76:18

these iron drinks.

76:19

>> Were you iron deficient?

76:21

>> No.

76:21

>> Okay.

76:21

>> I was just sick one time and they said

76:23

this would really help.

76:24

>> So,

76:25

>> this wasn't a scientist, just a friend.

76:26

Most men do not need to supplement with

76:28

iron unless they have, you know, a

76:30

problem with iron and they're anemic.

76:32

For example, iron can be very bad. I

76:35

mean, if you're supplementing with iron,

76:36

it's very reactive and it causes uh

76:40

oxidative stress easily. It's called

76:42

free iron. The free iron reacts with

76:43

other things with your DNA, your cells.

76:45

And so, most men do not need to sell. In

76:48

fact, even you know something called he

76:50

hemocchromattosis where there you're

76:52

basically you have too much iron already

76:54

and you if you have those genes it's

76:55

actually quite common then you're really

76:57

talking about iron overload. So you

76:59

really do not need a supplement with

77:01

iron.

77:01

>> Women

77:02

>> women premenopausal women are different

77:04

because premenopausal women do lose a

77:06

lot of iron from menration when they're

77:08

menrating. And so I would say about 16%

77:12

of of menrating women are iron

77:13

deficient. And then if you add exercise

77:15

on top of that, you know, a lot of

77:16

endurance exercise, you can get licis of

77:19

your red blood cells. And so you do need

77:20

iron for your red blood cells. If you're

77:22

eating meat, if you're not a vegetarian,

77:24

you know, maybe that would be a case if

77:26

you're like a vegan or something, maybe

77:28

some iron could come in, but you have to

77:29

get your iron levels measured. You don't

77:30

want to be too high because it is it

77:32

does cause damage.

77:33

>> But I would say that premenopausal

77:35

women, iron is especially around your

77:37

cycle is good. Post-menopausal women,

77:39

once you hit menopause,

77:41

>> it you kind of shift to like what a men

77:42

needs. You don't need the iron again.

77:44

So, it's very it's very much just

77:45

premenopausal women that need iron.

77:47

>> That's so funny. I've been drinking

77:48

these. Omega3. Does that

77:50

>> Yes. Omega-3 fish oil, as we've talked

77:52

about before. I mean, this is probably

77:54

one of the best and easiest things that

77:55

people can do to improve their health,

77:57

improve the way they age. Um, omega-3

77:59

fatty acids. 90% of the US population is

78:02

not getting enough of them. 80%

78:03

globally, everyone. Nobody's getting

78:05

enough omega-3 fatty acids, particularly

78:08

from seafood. So the EPA and DHA from

78:10

fish oil are probably the best forms.

78:12

You know, we talked about studies if you

78:14

have a high omega-3 index, you have a

78:16

fiveyear increased life expectancy

78:18

compared to low omega-3 index. If you're

78:20

a smoker and you have a high omega-3

78:22

index, then you're going to live as long

78:23

as a non-smoker with a low omega-3

78:25

index, right? I mean, so the low omega-3

78:27

index is like smoking. Basically, you

78:29

know, you have a 66% lower chance of

78:32

getting Alzheimer's disease with a high

78:33

omega-3 index. And even more recently,

78:35

there were studies showing that omega-3

78:38

slows epigenetic aging. Um, and this is

78:41

this is not just a in deficiency. I

78:43

guess because everyone's deficient,

78:44

maybe that's why, but um, a study showed

78:46

that omega-3 fish oil supplementation.

78:49

This was a study out of Switzerland.

78:50

These individuals are mostly active.

78:52

There were 88% of them were already

78:54

physically active at the start of the

78:55

trial. And I mentioned that because the

78:57

trial involved omega-3, it involved

78:59

vitamin D, and it involved resistance

79:01

training or the combination of all

79:03

three. And only the omega-3 was able to

79:05

slow epigenetic aging, biological aging,

79:08

because for one, they were already

79:10

physically active. So adding resistance

79:11

training on top of their baseline didn't

79:13

do much. And they were vitamin D

79:15

sufficient. So the omega-3 was able to

79:17

slow epigenetic aging. The combination

79:19

of all three slowed it by four months.

79:22

This was just after one year.

79:24

>> So slowed it by four months. And if you

79:26

imagine that, uh, it doesn't sound like

79:27

a lot. Again, it's compounding, but also

79:29

within that study, they looked at

79:31

realworld outcomes. So that also

79:33

correlated with they had a 60% less

79:36

likely chance of being pre fail uh pre-

79:38

frail. So pre-frailty, right? Um they

79:40

also were less likely to get cancer as

79:44

well. So I mean it's really kind of

79:45

translating to these health outcomes

79:47

that we think of. And all you need to do

79:49

is supplement with about 1.6 to two

79:51

grams a day of omega-3 to get a good

79:54

omega-3 index. But I will mention one

79:55

thing, Stephen, it's at room

79:57

temperature. I don't think that's a

79:59

great idea. Um because fish oil is a

80:02

polyunsaturated fatty acid. It is prone

80:04

to oxidation. So you want to put it in a

80:06

low temperature environment. I keep all

80:08

my actually I keep all my fish oil

80:10

frozen. Frozen and then when I'm ready

80:12

to use it, I put it in the fridge. So

80:14

like I have a store of it. I have a

80:15

stock of it I buy and then it's in the

80:17

freezer and then I put it in the fridge

80:18

with the the bottle that I'm using from

80:20

and it's freezing it does nothing. It's

80:22

fine. It so it's basically just keeping

80:24

it really really low oxidation.

80:25

>> So I need to put this in the fridge. You

80:27

need to put it in the fridge and also

80:28

make sure you're getting a quality

80:29

brand, right? So, you're going to third

80:30

party testing. Again, you want to have a

80:32

total oxidation, ideally less than 10.

80:36

And there are brands out there that do

80:38

have a oxidation less than 10,

80:40

>> which means it's more fresh and pure.

80:41

>> It's more It's Yeah, it's less oxidized.

80:43

You don't want to be consuming oxidized

80:44

fat because that's also not good.

80:47

>> Okay. So, what else jumps out to you

80:50

here? We've got creatine. I mean,

80:52

>> yeah, creatine is like my new I travel

80:54

with it everywhere. You got microionized

80:57

is this this is

80:57

>> I've got so many different types,

80:59

>> right? This is the one I take. Yeah, I

81:00

take I take the creatine monohydrate

81:02

because it's the most wellstudied

81:04

>> and you know obviously for I do a lot of

81:07

training and workout train you I do a

81:09

lot of resistance training and strength

81:10

training. So I at least get five grams a

81:12

day which is what I always was doing in

81:13

the past. I up that to 10 grams a day as

81:16

my baseline because I wanted to have

81:17

benefits in my brain. Studies out of

81:19

Germany show that once you get to the 10

81:22

gram mark, you're actually your brain is

81:23

able to take it up and it's increasing

81:25

creatine in certain brain regions. That

81:28

doesn't happen much at lower doses and

81:30

that's because your muscles are very

81:32

greedy. The creatine in my brain,

81:33

honestly, I've for me, I've mentioned

81:35

this before, it's a game changer just on

81:37

a daily basis. I feel like I don't have

81:39

that afternoon slump. I'm in my mid-4s.

81:42

My brain isn't as sharp as it was.

81:45

Creatine has really helped me kind of

81:46

get a little bit closer to where I used

81:48

to be. And also when I'm sleep deprived,

81:51

I go up even higher. Sometimes I do 20

81:52

25 grams. And that is because studies

81:55

have shown if you go up to a higher dose

81:57

like that, depending on your weight,

81:59

it's kind of a scale. Um that it helps

82:01

you basically negate the negative

82:03

effects on your brain from sleep

82:04

deprivation where not only are you

82:06

cognitively functioning, you're

82:07

functioning beyond what your even normal

82:09

baseline was, which was kind of

82:11

mind-blowing. The question I had is

82:13

around loading and how long it takes to

82:16

feel the impact. Because when I first

82:19

heard about creatine, I was 16 and my

82:20

brother was bodybuilding and they were

82:22

told that you need to like load up on

82:23

big loads of it and then in like two

82:25

weeks time your body would be saturated.

82:27

What's the truth?

82:28

>> Right? So the reason that creatine

82:30

loading was done was because they

82:33

there's a short window of time when

82:35

researchers are doing a study

82:37

>> and they want their muscle stores to be

82:39

saturated. They want their their muscle

82:41

stores to be saturated and so you have

82:43

to do 20 gram loading phase in order to

82:45

saturate them after you know three or

82:48

four days.

82:49

>> If you're not about to compete and if

82:52

you haven't been using creatine and

82:53

you're not participating in the study,

82:54

it takes about four week 3 to four weeks

82:57

of five grams a day consistently to

83:00

saturate your muscle. So you don't have

83:02

to do any loading phase. If you are

83:04

supplementing with five grams a day and

83:05

you've been doing it for a month, your

83:07

muscle stores are saturated until you

83:09

exercise and you get that five grams in

83:11

again. They're saturated, right? So,

83:12

they keep they're they're already that

83:13

five grams a day is keeping them

83:14

saturated. And that's why I said your

83:16

muscles are really hungry and greedy.

83:18

They're wanting that five grams. They're

83:19

wanting that five grams. And that's

83:21

about what it takes daily to saturate

83:22

them. However, if you're starting from

83:24

ground zero where you've never taken

83:26

creatine, it's going to take four weeks

83:28

to really get the effects. Otherwise,

83:31

yeah, you'll have to get higher doses.

83:32

are not going to be saturated after 5 g.

83:34

>> So, some people might have tried

83:35

creatine for a week, have not felt any

83:37

effect, and given up.

83:39

>> That's a good that's actually a really

83:40

good point. Yeah, it's about a

83:41

month-long experiment. I would say close

83:44

to four weeks. I think some people can

83:45

saturate it at 3 weeks, but it all

83:47

depends body size and all that. So, four

83:49

weeks is a good experiment time and five

83:51

grams is a good dose to start with. If

83:53

five grams a day actually help makes you

83:56

more bloated and nauseous, cut that down

83:58

to 2 and 1 half and 2 and 1/2 grams so

84:00

that you split the doses. If you split

84:01

the doses, if you take it with food,

84:03

particularly carbohydrates, it seems to

84:05

help negate some of the bloating and

84:06

nausea and negative effects people feel.

84:08

And obviously, if you're not working

84:09

out, you know, creatine is not going to

84:12

like grow your muscles. You have to put

84:13

in the work. You have to put in the

84:15

effort. It's what it's doing is it's

84:16

helping your muscles, you know, grow and

84:18

give you the energy to to do more

84:20

training volume so that they can grow

84:22

bigger and also so that you can be

84:23

stronger. If you're traveling and

84:26

stressed and all those things, yes,

84:28

creatine is good for the brain. I was

84:30

seeing I think it was James Smith did a

84:32

video about different creatine

84:34

percentages in the creatine products we

84:36

drink and um or eat or consume and he

84:38

looked at creatine gummies and found

84:40

that some of the creatine gummies don't

84:41

even have any creatine in them at all.

84:44

And it was quite shocking because you

84:45

just assume that if it says creatine

84:46

there's going to be creatine in there.

84:48

>> This goes back to the whole problem

84:49

where supplements are not regulated and

84:52

so you never really know what you're

84:53

getting and you have to have third party

84:55

testing and go to a quality brand.

84:56

Gummies in general. So, there was a

84:58

study that was published not long ago.

85:00

It was a consumer study that was done

85:02

where people went and got a lot of

85:04

different creatine gummies off the shelf

85:06

and then measured how much creatine was

85:07

in them. And essentially almost all of

85:09

them had none. And I've talked to some

85:12

supplement manufacturers and their

85:14

basically their statement was it's

85:17

really hard to get active ingredients in

85:18

gummy in general, not even just creatine

85:21

in general. But the other thing I did

85:23

want to mention with creatine is that

85:25

you do want to make sure it's NSF

85:26

certified. That's a really important

85:28

thing because there are contaminants

85:31

that are even produced in the processing

85:34

of creatine and creatine monohydrate.

85:37

And so you want to make sure that you're

85:38

not getting those contaminants which can

85:40

be harmful. And some of them are like

85:41

lead for example, but even some other

85:43

compounds that are formed. And so you

85:45

want NSF certification. And that's

85:48

always what I look for when I'm buying a

85:49

creatine supplement is NSF certification

85:52

or any supplement. I really like to have

85:53

all supplements NSF certified because

85:55

that really means they've one looked at

85:57

contaminants and two it's got that

85:58

active ingredient in there and that's

86:00

really what you want.

86:01

>> And the NSF certification is just a

86:03

little logo on the side of the tub here

86:05

that says NSF certified sports.

86:07

>> That's it. Yeah. And it's all on

86:08

websites, too, if you buy online. Yeah.

86:10

>> Okay. So, I've got one challenge for

86:11

you. If you had to pick five supplements

86:13

for me to take, assuming that I am

86:18

male and female.

86:19

>> Okay.

86:20

>> Okay. So, it's neither gender. Um, and

86:22

it can be things that are either

86:23

currently in my cupboard or not. What's

86:26

the top five? And ideally, give me them

86:28

in order if you can, in order of

86:29

importance.

86:32

>> Fish oil

86:33

>> number one.

86:33

>> Number one,

86:35

vitamin D.

86:38

Multivitamin.

86:40

All three very very strong evidence that

86:43

you're going to slow aging, you're going

86:45

to improve your brain function, lower

86:48

disease risk, live longer, and creatine

86:50

is going to be there.

86:51

>> So that's one, two, three, four.

86:53

>> And then the last one is magnesium.

86:55

Magnesium would be I mean it might be

86:57

number four and creatine number five

86:59

actually.

87:00

>> Really?

87:00

>> Yeah. Um

87:02

>> you sure?

87:03

>> What is magnesium doing for me?

87:04

>> Magnesium is running. It's important for

87:07

300 different enzymes in your body. It's

87:09

important to repair damage to your DNA

87:11

that's being done all the time. It's

87:13

being done from the iron that you're

87:14

taking. Um, it's being done from normal

87:16

metabolism, normal immune activation,

87:18

but when you're in a state where you

87:20

have you're, you know, not eating a good

87:21

diet or you're not getting enough sleep,

87:23

magnesium is really important to repair

87:25

that damage. And that's why studies have

87:26

shown that magnesium is really important

87:29

for preventing cancer. And it also helps

87:32

with sleep. It's really good for sleep.

87:34

But more importantly, 50% of the

87:36

population doesn't get enough magnesium.

87:37

And I bet you're probably one of those

87:39

people because most of us are. Do you

87:40

eat a lot of dark leafy greens or

87:42

almonds?

87:45

You're supposed to be getting 400 about

87:46

350 to 400 milligrams a day. Are you

87:48

physically active? Yeah. You're sweating

87:50

magnesium out. Let's make it six

87:52

supplements. So, there's a new

87:53

supplement uriththn that I'm pretty

87:56

excited about. The other thing I take

87:58

that's really important is that I don't

88:00

necessarily see here.

88:02

>> What's it called?

88:03

>> Um, so curcumin. All those supplements

88:06

you've mentioned, the first one which I

88:08

can't say and the second one cumin, we

88:09

have on the table in the studio. So,

88:11

let's get back into the studio and we'll

88:13

pick up from there.

88:16

>> Steve, what are you doing?

88:17

>> Uh, just making myself a delicious

88:19

coffee

88:20

>> from the freezer.

88:21

>> From the freezer? Have you not heard

88:22

about Compier?

88:23

>> No.

88:24

>> Oh my gosh, this is going to change your

88:26

life. A couple of months ago, the

88:28

founder of this business called Matt

88:29

sent a big shipment of this coffee to

88:32

our office in London. What most people

88:34

don't know is that the processing of

88:35

coffee takes out a lot of the taste. So

88:37

what they do is they flash freeze it at

88:40

the optimal moment when it's most tasty

88:43

and they send you in the post the coffee

88:45

in these little frozen ice cubes. Now

88:47

Max sent a big shipment to my office. I

88:49

moved it to the kitchen. I said to the

88:50

team, "Knock yourselves out." And then I

88:52

saw so many messages in our Slack

88:53

channel of people going, "Oh my god,

88:55

what the hell is that? It's so

88:57

delicious." All I have to do is pop it

88:59

out in the morning using the little

89:00

button on the back of this thing. I pour

89:02

my hot water in and I mix it and that is

89:06

done. You can get $30 off your first

89:09

order of Cometier coffee if you go to

89:12

cometier.com/stephven.

89:14

Try it and please Instagram DM me,

89:17

LinkedIn me and let me know if you love

89:18

it as much as I do. You know, every once

89:21

in a while you come across a product

89:23

that has such a huge impact on your life

89:25

that you'd probably describe it as a

89:28

gamecher. And I would say for about 35

89:32

to 40% of my team, they would currently

89:35

describe this product that I have in

89:36

front of me called Ketone IQ, which you

89:39

can get at ketone.com

89:41

as a game changer. But the reason I

89:43

became a co-owner of this company and

89:44

the reason why they they now are a

89:45

sponsor of this podcast is because one

89:48

day when I came to work, there was a box

89:49

of this stuff sat on my desk. I had no

89:51

idea what it was. Lily in my team says

89:53

that this company have been in touch. So

89:54

I went upstairs, tried it, and quite

89:57

frankly, the rest is history. in terms

89:58

of my focus, my energy levels, how I

90:01

feel, how I work, how productive I am.

90:04

Game changer. So, if you want to give it

90:06

a try, visit ketone.com/stephven

90:08

for 30% off. You'll also get a free gift

90:10

with your second shipment. And now you

90:12

can find Keton IQ at Target stores

90:14

across the United States, where your

90:16

first shot is completely free of charge.

90:19

Make sure you keep what I'm about to say

90:21

to yourself. I'm inviting 10,000 of you

90:23

to come even deeper into the diary of a

90:25

CEO. Welcome to my inner circle. This is

90:28

a brand new private community that I'm

90:31

launching to the world. We have so many

90:32

incredible things that happen that you

90:34

are never shown. We have the briefs that

90:36

are on my iPad when I'm recording the

90:38

conversation. We have clips we've never

90:40

released. We have behind the scenes

90:42

conversations with the guests and also

90:43

the episodes that we've never ever

90:45

released. And so much more. In the

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circle, you'll have direct access to me.

90:50

You can tell us what you want this show

90:52

to be, who you want us to interview, and

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the types of conversations you would

90:55

love us to have. But remember, for now,

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we're only inviting the first 10,000

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people that join before it closes. So,

91:02

if you want to join our private closed

91:03

community, head to the link in the

91:05

description below or go to

91:06

daccircle.com.

91:09

I will speak to you then.

91:13

So, phytoal curcumin is another one that

91:16

I supplement with. And let's just start

91:19

with curcumin in general. Curcumin is

91:21

found in the turmeric plant. It's

91:23

something that is able to pretty

91:27

robustly and I would say consistently

91:29

lower inflammation.

91:31

And it's doing it in a different way

91:33

that like a NSAIDE like an ibuprofen

91:36

would do it, right? And that is

91:37

important because

91:40

it's been shown if you take NSAIDE,

91:43

right? So these non-steroidal

91:45

anti-inflammatory drugs, something like

91:46

ibuprofen

91:48

around exercise, it can blunt the

91:50

adaptations because it's basically

91:52

lowering inflammation and and

91:54

prostaglandins and things that are

91:56

important to cause exercise adaptations.

91:59

So curcumin doesn't hasn't been shown to

92:01

do that but it has been shown to lower

92:03

something called TNF alpha and that is a

92:05

major inflammatory cytoine that is

92:10

really really powerfully accelerating

92:12

aging. In fact those epigenetic aging

92:15

clocks that we talked about earlier one

92:18

of the most powerful drugs that's able

92:20

to slow them are TNF alpha inhibitors.

92:23

So these are drugs that people take to

92:25

inhibit TNF alpha. Certain people take

92:27

them, like people with rheumatoid

92:29

arthritis, they have a high level of

92:30

inflammation. Their immune system is

92:32

overactive. They're making a lot of it.

92:34

Well, guess what? Those individuals

92:35

taking TNF alpha inhibitors are like

92:38

they have a 50% less likelihood of

92:40

getting Alzheimer's disease than people.

92:43

>> 50%.

92:44

>> Mhm. Yes. So, I like it because curcumin

92:48

is one of the most it is the

92:51

na most naturally occurring dietary

92:53

compound that I've seen data showing

92:56

that it lowers TNF alpha. I haven't seen

92:58

anything else that's naturally occurring

93:00

that does it. This does it. It lowers it

93:02

by quite a bit by almost five pogs per

93:05

milliliter. Phytoal curcumin is the

93:08

reason I take phytoal. It's kind of like

93:09

a liposome but it's phytome. So, it's

93:12

essentially just making the ingredient

93:14

get into the cells better. It's more

93:15

bioavailable

93:16

>> because curcumin is easily metabolized

93:20

quickly by the liver. It's a it's what's

93:21

called a xeninoiotic. It's not a

93:23

compound that's a vitamin or a mineral

93:25

or something that the body body normally

93:26

recognized. It's seen as a drug, a

93:28

foreign drug, xeninoiotic, right? And so

93:31

the liver gets rid of it quickly. The

93:33

phytoal delivery of it kind of slows

93:35

that whole process where it's not

93:37

getting rid of so quickly. It's not

93:39

being metabolized so readily. So that's

93:40

why I take that. And also it's been

93:42

shown to improve performance in people

93:44

that are exercising again because it's

93:46

reducing inflammation. Inflammation can

93:47

be dampening for performance.

93:49

>> And what else have we got here?

93:51

>> The other supplement that I really want

93:52

to talk about is the uraliththan A. And

93:56

as I mentioned, this is a compound

93:57

that's usually generated in the gut by

94:00

the bacteria in your gut. It's something

94:03

that we can get from our diet. So if we

94:05

eat things like pomegranate, pomegranate

94:07

has a type of polyphenol in it called

94:09

elagitanins.

94:11

>> I've never heard about this before.

94:13

>> Okay, listen to this. This is this is

94:15

like you got to try this supplement.

94:16

Uthin A again, it's made from eating

94:18

things like pomegranate. However, 50% of

94:21

the population doesn't have the right

94:23

bacteria to make it. So you're kind of

94:24

like a to a coin toss if you eat

94:26

pomegranate. Am I going to be the person

94:28

that can make uriththna or am I not?

94:30

Right? So there was a company that did

94:32

out of Switzerland these stud a lot of

94:34

these early studies were done in

94:35

Switzerland and they ended up making

94:37

uriththn and then testing you know doing

94:39

clinical studies doing animal studies

94:41

first and then clinical studies to test

94:43

you know what is uroliththna doing. So

94:44

what is it? It is a compound that is

94:47

able to basically get rid of damaged

94:50

mitochondria. So it's called mphagy.

94:54

You've probably heard of autophagy. you

94:56

know getting clearing out your all the

94:58

gunk and the trash from your cells

95:00

making them rejuvenating rejuvenating

95:01

them right

95:02

>> which is associated with fasting.

95:03

>> Fasting activates autophagy. Fasting

95:06

activates mphagy which is specifically

95:09

just clearing out damaged mitochondria

95:11

or pieces of damaged mitochondria.

95:13

Autophagy is essentially you have a

95:15

whole cell

95:16

>> and within that cell you have a lot of

95:19

different organels they're called. So

95:21

mitochondria being one and so autophagy

95:24

kind of helps clear out all the stuff

95:25

inside of the cell. Mphagy is very

95:29

specific to just the mitochondria within

95:31

the cell. Those mitochondria get older

95:34

and they don't have a really good repair

95:36

process and so they accumulate damage

95:38

and as they get older you're you're not

95:40

going to be making energy as well.

95:42

You're not going to be using energy as

95:43

well. It's going to affect all the cell

95:46

function because energy is at the core

95:48

of everything, right? So mitochondrial

95:50

health is at the core of all health

95:52

basically. This compound very robustly

95:55

induces mphagy. And so um there have

95:58

been of course many animal studies that

95:59

were done preclinally before clinical

96:01

studies were done. Animal studies were

96:04

exciting. I mean mice that were given

96:05

old mice that were given uraliththna

96:07

were able to like rejuvenate you know

96:09

tissues but also 20% life extension was

96:14

found in these mice given uralithn. 20%

96:16

is pretty big for a mouse mouse study.

96:19

All right, but we're not mice. So, let's

96:21

talk about humans and why I'm actually

96:22

excited about it. For one, urthan A and

96:26

mphagy was shown to be activated in

96:29

humans taking it. So, they took muscle

96:30

biopsies and found that in fact mphagy

96:33

was activated. It's also recently been

96:35

shown that this uriththnan A is able to

96:38

to basically rejuvenate the immune

96:40

system. So older adults were given a

96:42

thousand milligrams a day and it it

96:44

basically as we age our immune system

96:47

ages our te- cells aren't fighting off

96:49

pathogens as well and it increased the

96:51

number of a very specific type of immune

96:53

cell that decreases with age called CD8

96:56

positive tea cells. Those were

96:58

increased. That's very important because

96:59

you're able to fight off infection

97:01

better. And then it also increased a

97:03

kind of immune cell that's able to kill

97:05

cancer cells and also kill viruses and

97:07

pathogens. it's called natural natural

97:10

killer cells. Um so those cells

97:12

increased as well with the uriththan a

97:15

and it also decreased markers of like

97:18

scinsessence. So this is basically when

97:20

a cell is still alive but it's not

97:23

functioning it's basically like it's

97:25

dead but not only is it not dead and not

97:27

functioning it's secretreting

97:28

inflammatory cytoines accelerating

97:30

aging. I know it's complicated. So the

97:32

study showed that it was basically able

97:34

to re rejuvenate the immune system in

97:35

older adults younger adults that have

97:37

taken it. So, there's been studies

97:38

showing that untrained athletes

97:41

supplementing with 1,000 milligrams a

97:42

day were able to improve their V2 max um

97:46

10% more than just exercise alone. So,

97:49

if they exercise and took uriththan A,

97:51

their V2 max went up 10% compared to the

97:54

exercise alone group. Wow.

97:55

>> If they were Yes. If they were trained

97:57

athletes, it only went up 5% because

97:59

trained athletes already are doing a

98:01

lot, right? So, you always get a bigger

98:03

increase in B2 max if you have an

98:04

untrained athlete. Same with obese

98:06

people.

98:07

And on top of that, so again, energy,

98:10

it's you're clearing out damaged

98:12

mitochondria. If you combine it with

98:14

exercise, exercise causes you to make

98:17

new mitochondria. So the way I look at

98:19

it, Stephen, is a rejuvenation of all

98:21

your mitochondria within your cells,

98:22

whether we're talking about your muscle

98:24

cells or your immune cells. I think it's

98:26

probably happening in the brain as well.

98:28

So it's been shown to increase muscle

98:30

strength in older adults. So, their

98:31

hamstring strength improved by like 10

98:33

to 12% after supplement supplementing

98:36

versus just exercise alone. I think it's

98:38

a supplement that's important for aging

98:40

because it's affecting mitochondria and

98:42

pretty much everything relies on

98:43

mitochondria.

98:44

>> And you can buy this in a normal shop on

98:46

the high street.

98:47

>> You cannot buy it in a normal shop. You

98:49

can buy it online. It's not cheap,

98:52

unfortunately. Uh that's the other

98:54

thing. So, pomegranate itself is the

98:56

next best thing for people. And there

98:58

are studies showing that people that

99:00

take pomegranate juice before they

99:02

exercise they and over over the course

99:04

of several weeks can actually increase

99:06

their V2 max by up to 17%. This is

99:09

analysis of multiple studies showing

99:10

that. So again I think it's all coming

99:12

down to the uriththna and it's a new

99:15

supplement that I'm I've been

99:17

experimenting with. Again the immune

99:19

system effects. I think I'm not getting

99:21

sick but I'm doing the creatine. I'm

99:22

doing the uriththna and I'm doing

99:24

glutamine.

99:24

>> So glutamine is the last one. What what

99:26

is that? Well, you probably heard of

99:28

glutamine as an amino acid, right? It's

99:31

so much more. It's so much more. So,

99:33

glutamine is something that it is an

99:35

amino acid, but it gets converted into

99:39

and metabolized to many different

99:41

things. So, one, it can be an amino

99:43

acid. Two, it can form something called

99:45

glutarate, which is used by your cells

99:49

for energy. Mitochondria love it. Or it

99:51

can be converted into that

99:53

neurotransmitter that we were talking

99:54

about, right? Glutamate. So, it's really

99:57

something that can be used for many

99:58

things. I supplement with it because I

100:02

came across some studies in the past

100:04

couple of years where endurance

100:06

athletes, so these are I'm not an

100:07

endurance athlete, but endurance

100:10

athletes are very prone to respiratory

100:13

illness because they're really just

100:14

going hard, right? And their im your

100:16

immune system kind of takes a takes it

100:18

takes attacks on your immune system.

100:21

studies were showing that if those

100:22

endurance ath athletes supplemented with

100:24

glutamine, they didn't get sick as

100:26

often. They were having fewer

100:27

respiratory illnesses. And I remembered

100:30

back to when I was a graduate student

100:31

and I was doing research and I used

100:33

glutamine. And I was doing glucose and

100:35

glutamine and looking at immune cells

100:37

and how I could make them active or what

100:39

happens if I get rid of glucose or

100:40

glutamine. And I remembered how much

100:43

they love glutamine. They consume it.

100:45

They're using it for energy.

100:47

>> And it started to make sense to me. And

100:49

this was during a period of time where,

100:51

you know, again, mid-4s, your immune

100:53

system is not going doing as well as it

100:54

used to. I've got a had a young child

100:56

that was bringing home all sorts of

100:58

pathogens. And so, I started

100:59

supplementing with glutamine. And it

101:02

could be placebo, but again, I you know,

101:04

the sickness bouts were going down. I

101:07

wasn't getting sick as often. The other

101:09

thing it's good for is the gut. And that

101:12

is because glutamine can be glut uh

101:14

converted into something called alpha

101:15

ketoglutarate which is a important

101:19

energy compound that the gut uses. And

101:21

so there are studies showing that it's

101:23

beneficial for gut health. I think

101:24

that's what a lot of people think about

101:25

when they take glutamine is their gut.

101:27

I'm thinking about my immune system. But

101:29

basically it's very easily used by the

101:32

gut cells as energy and that really

101:34

helps the gut heal.

101:35

>> Okay. The other thing which I take

101:38

almost daily. Sometimes I give myself

101:40

the weekend off depending on how things

101:42

are going, but almost daily are these

101:43

ketone IQ shots which I am affiliated

101:45

with. I I'm an investor in the company.

101:48

Ketone shots, exogenous ketone shots.

101:50

>> I take them also quite frequently, not

101:52

daily. Um, you know, so what are they

101:56

doing? There's different forms of them

101:58

and why do I take them and I think let's

102:01

talk about what I think people should

102:02

realize if they are taking them. So, you

102:04

know, there it's an it's it's

102:05

essentially giving you that metabolic

102:07

switch, right? It's getting getting your

102:08

ketone levels up as if you were fasted.

102:11

So you're you're elevating your beta

102:12

hydroxybutyrate levels. That's the major

102:14

circ circulating ketone.

102:16

>> Beta hydroxybutyrate,

102:17

>> BHB for short.

102:19

>> Does that just mean ketone?

102:20

>> It's a ketone. It's there are several

102:22

ketones. Acid acetone is another ketone,

102:25

but that beta hydroxybutyrate is the

102:28

major one, right? So and and that is a

102:31

major ketone that's in in your body when

102:33

you're fasted. That's what you're

102:34

making. And when you're taking these

102:36

ketone IQs or other exogenous ketones is

102:39

what you're going to get. So ketone IQ

102:41

is got the precursor for the ketone.

102:43

It's got 13 butane dial that in your

102:46

liver gets converted into beta

102:47

hydroxybutyrate. I take a ketone that

102:50

has 13 butane dial but also it's

102:52

asterified to the actual beta

102:54

hydroxybutyrate.

102:55

>> What does that mean? It means that it

102:57

has both an immediate action, a fast

103:00

action effect of having your ketones

103:02

elevated, but it also has a tail end

103:04

effect. So the 13 butane dial, if you

103:06

take it, you have to wait for it to get

103:08

to your liver.

103:12

>> You have to Can I have one?

103:14

>> Yes. You have to wait.

103:16

>> Oh, perfect. Okay.

103:20

>> Wow, those taste better. M.

103:22

>> So,

103:23

so the other ketone exogenous ketone is

103:26

the beta hydroxybutysterified

103:28

to the 13butin dial which just means

103:30

it's going to have a fast acting effect

103:33

but also a long-term effect. So you

103:35

you'll get a little bit more elevation

103:37

in your blood ketones from from the one

103:39

that has the beta hydroxybutyrate to the

103:41

13bin dial. That said,

103:43

>> the difference is I think from what I

103:45

know and I don't know a ton is pricing.

103:47

>> Yes, it's pricing but also again

103:51

concentration. So, I mean, you know,

103:53

you're going to get you're going to get

103:54

a higher peak quicker and you're going

103:56

to get higher levels of it with the one

103:58

that's the the Oxford, you know, the

104:01

Oxford ketone, I guess it's called, but

104:04

the ketone IQ has 13 butane dial, which

104:07

does get converted into beta

104:08

hydroxybutyrate.

104:08

>> This one I think cost costs a couple of

104:10

dollars. And I have the Oxford one here

104:11

as well, which I think is $30 a pop. So,

104:14

it's quite expensive.

104:16

The reason why this has been able to

104:17

break into retail, especially across

104:18

America, is just because it's more

104:20

affordable for most people to be able to

104:22

take spend a couple of dollars,

104:24

>> right? The reason I take it is because I

104:27

like the cognitive boost that I get from

104:29

it. And I usually take it on occasions

104:32

like this when I'm doing a show or I'm,

104:35

you know, doing a presentation or I just

104:37

I'm doing a lot of heavy research and I

104:39

just need to be on because I get a

104:41

cognitive boost from it. And that

104:42

cognitive boost does come down to what I

104:44

was talking about with why I like to

104:45

fast. It's mimicking that, right? I have

104:48

that beta hydroxybutyrate which is

104:50

increasing GABA, that inhibitory

104:52

neurotransmitter that's silencing down

104:54

some of the anxiety in the back of the

104:55

brain or the chatter and just helping me

104:57

focus. And also it increases brain drive

105:00

neurotrphic factor. So beta

105:01

hydroxybutyrate is a signaling molecule.

105:04

It's able to increase brain drive of

105:06

neurotrophic factor in the brain that

105:08

helps with learning, memory, brain

105:09

aging. It's also been shown to lower

105:12

oxidation. So, there's all sorts of

105:14

reasons why I like to take it. For

105:16

people that are fasting and they're

105:19

wanting to burn fat,

105:21

consider that if you take exogenous

105:24

ketones, you stop you stop burning your

105:26

own fat because your body thinks it's

105:28

now got all it's got the ketones there,

105:30

which is what the metabolism of fat is

105:32

trying to do is produce ketones for

105:34

energy. And so, it does shut down what's

105:36

called lipolysis, which is basically

105:38

breaking down fat. And so if you're

105:40

doing fasting and you're doing it for

105:42

reasons of fat loss, if you take an

105:45

exogenous ketone during that period of

105:47

time, it will transiently kind of shut

105:49

down that process. So keep that in mind.

105:51

It's one reason why I don't do it every

105:52

day because I am looking for that effect

105:55

for losing visceral fat in particular.

105:57

>> That's a really interesting important

105:59

point.

105:59

>> It is

106:00

>> that people don't talk about.

106:01

>> Yeah, it's important and it's only going

106:03

to last as long as the beta

106:05

hydroxybutyrate lasts in your in your

106:07

blood system. So, you know, maybe 3

106:09

hours max.

106:10

>> What I noticed was when I was trying to

106:12

get into ketosis at the top of the year

106:14

and I was doing exogenous ketone shots.

106:16

I was struggling to get into ketosis.

106:19

And so, what I did is I stopped taking

106:20

the ketone shots for a couple of days,

106:22

just focused on my ketogenic diet. I got

106:24

into ketosis and then afterwards I

106:27

started taking the ketone shots when I

106:29

was doing podcasting because just like

106:30

you, I noticed just such a radical

106:33

radical difference when I take exogenous

106:35

ketones or when I'm in a natural sort of

106:36

dietary ketosis. Radical difference. And

106:39

as a podcaster, I've said this a million

106:41

times before, but I'm going to say it

106:42

again. Two times a week, I do an AB test

106:45

of how my brain is working. I sit with

106:47

someone who is an expert in what they do

106:49

for sometimes four or five hours and I

106:51

look at them in their face and I have to

106:52

ask questions and respond and understand

106:54

big words and hope that my brain is

106:56

connected to my mouth today. And so I've

106:58

done 600 or 700 of these AB tests now.

107:01

And one of the the factors that

107:03

correlates to good performance as an

107:04

interviewer, a thinker or a speaker on

107:06

stage is whether I'm in a ketosis state

107:09

or not. And it's so profound. In fact,

107:12

I've actually heard Joe Rogan say this.

107:14

Rogan said that the upside he gets from

107:16

being in a ketogenic state is so evident

107:19

for him as an interviewer that he he's

107:21

considered being in that state all the

107:23

time.

107:24

>> It's the same for me too. I mean, as you

107:26

know, I'm also doing the same thing,

107:27

right? I'm I have a podcast and I'm

107:29

giving presentations and very very much

107:32

having to use my brain and be on and

107:35

it's really made a huge difference for

107:37

me as well. And that is also why I like

107:39

to fast because I get the same effect

107:41

when I'm when I'm fasted. And then I

107:43

will take an exogenous ketone when I'm

107:45

also fasted. And so I get into ketosis

107:47

quicker as well

107:49

>> because I'm already I'm already kind of

107:51

there. I don't have other things

107:52

inhibiting it.

107:53

>> So it does help. And there's again pros

107:56

and cons to doing it. You do want your

107:58

body to be metabolic flex flexible. So

108:00

I'm glad you did do the keto like the

108:02

ketogenic diet and let your body kind of

108:03

do it and adapt and then add the ke

108:05

ketones on top of that. But um they do

108:08

help. They help with cognitive function

108:10

for sure. I mean I I use them every

108:13

single podcast I do, presentation I'm

108:15

giving. It's it's part of my routine.

108:18

>> Let's talk about something different,

108:20

which is something that I've never heard

108:21

of before. Um it's a word that you

108:24

started to make popular in the health

108:26

and longevity community, which is this

108:28

idea of peak span.

108:31

I have this graph in front of me, which

108:32

I'll throw up on the screen. It's

108:33

fascinating. What the hell is peak span?

108:35

I've heard of health span. I've even

108:38

heard of lifespan, but I've never heard

108:40

of peak span.

108:41

>> Well, let's start with lifespan and work

108:43

our way to peak span to give people a

108:45

frame of reference. I think most people

108:47

are familiar with the word longevity,

108:50

>> wanting to extend their lifespan, how

108:51

many years they live, how long they

108:53

live, right? But the problem with

108:55

lifespan is well, you could live longer,

108:58

but you're going to have per perhaps you

108:59

have some diseases. So why do you want

109:02

to live longer if you have Alzheimer's

109:03

disease or cardiovascular disease or

109:06

type two diabetes? I mean the qual your

109:07

quality of life is not as good and

109:09

that's where this idea of health span

109:10

came in right so health span is well

109:13

let's increase the amount of time we

109:15

live diseasefree

109:17

>> and that's the new thing that everyone

109:19

wants to increase and improve their

109:20

health span I want to live I want to

109:22

increase my health span so I want to

109:23

live longer and not have any diseases

109:26

while I'm living that that longer life.

109:28

Well, there's this new concept now, very

109:30

new that was just published by some

109:32

researchers out of Duke University as

109:34

well as I think um the China

109:38

some university in China and another

109:40

university, but I want to give them

109:42

credit. They just it's a pre-print study

109:44

and it came out on my radar. I

109:46

immediately loved it. And this is idea

109:47

of peak span. Peak span says, hey, you

109:51

know, health span is great. Being

109:53

disease-free is great, but you're still

109:54

in a period of decline. You're still

109:56

declining.

109:58

Why not try to be as close to your peak

110:02

span which is essentially within 90% of

110:06

your peak function for a certain

110:09

measurement whether we're talking about

110:11

V2 max cardiorespiratory fitness we're

110:13

talking about you know any any other

110:15

function and that's where this graph

110:17

comes in on the y ais we have our

110:20

relative capacity

110:21

>> so if you're listening now this is a

110:22

good time to look at the screen because

110:24

uh Rhonda's going to show us something

110:26

okay your relative capacity 100 being

110:29

100% and zero being 0%.

110:31

>> What does relative capacity mean?

110:33

>> Your capacity for cognitive function for

110:37

you know your fertility

110:40

hormonal Yeah. your potential. Yeah.

110:43

>> And on the x- axis we're talking about

110:45

age, right?

110:46

>> And so what you'll notice is that

110:49

different capacities, different organ

110:51

functions kind of peak at different

110:53

rates. So we can talk about first

110:57

obviously female reproductive

110:59

really starts to peak at you know 25 or

111:03

so and then it just sharply declines

111:06

until you hit 40 right and it's like b b

111:08

b b b b b b b b b b b b b b b b b b b b

111:08

b b b b b b b b b b b b b b b b b b bmed

111:08

out. So that's the reproductive female,

111:11

right?

111:12

>> Mhm.

111:12

>> Immune function. So let's find immune

111:15

function here.

111:16

>> That kind of peaks around 25 years old

111:21

and it also kind of declines and it

111:24

keeps declining.

111:25

>> It's quite scary

111:26

>> as you get to 80.

111:27

>> And then we have muscular skeletal,

111:30

right? So this is our peak strength,

111:32

peak muscle mass, peak bone density.

111:35

Those also peak around 25 and then they

111:38

kind of steadily start to decline. And

111:40

the same goes for cognitive function. We

111:42

have two different kinds of cognitive

111:43

function. We have fluid cognitive

111:44

function like processing speed. That is

111:47

the kind of I would say cognitive

111:49

function where you can answer a question

111:51

without any prior knowledge.

111:53

>> Mhm.

111:54

>> You know that. So that peaks around 25.

111:56

>> You're joking.

111:57

>> No, I know.

111:58

>> So I'm on the way down.

111:59

>> You're on I'm definitely on the way

112:01

down. You're on the way down as well. So

112:02

that would be the blue one here. Peaks

112:05

around 25. And then we have the

112:08

crystallized cognitive function.

112:09

Crystallized cognitive function is

112:11

interesting because it peaks around

112:13

midlife. And the reason it peaks around

112:15

40, 45 is because it's the kind of

112:18

intelligence that it's like the library

112:21

where you have all these facts that

112:23

you've accumulated over the years and

112:24

you're able to use those facts to answer

112:28

or solve a problem, right?

112:29

>> Is that wisdom or is that

112:30

>> It really just means that you have all

112:32

these facts that you've learned over

112:34

your life. Like for me, you know, I've

112:36

been a biologist for since I was, you

112:38

know, 20, so 27 years. I have so much

112:42

that I've learned over that time. And so

112:44

now I'm sitting here and I use that

112:46

knowledge. I talked about glutamine,

112:47

what I learned from graduate school. I'm

112:49

using that knowledge, right? Mphagy, I

112:51

learned about that like forever ago and

112:53

I've been following it. So you use all

112:54

this these facts and this data that

112:56

you've learned in your life and you're

112:57

able to solve problems. So fluid

113:00

intellig I'm sorry, crystallized

113:01

intelligence.

113:02

>> I've got to ask a question there. I I we

113:03

were sat having dinner the other day, me

113:05

and my team, and we were talking about

113:06

the difference cuz we're all different

113:07

ages. We've got someone in the team

113:08

who's 45, 35, 30, and it was the other

113:12

person at the table was 27. And we were

113:14

all talking about the differences we've

113:15

noticed in ourselves as we've aged. And

113:18

they all said different things. So Leona

113:20

and my team, who's just is above the age

113:22

of 40, was saying that she just like

113:24

doesn't really give a anymore in

113:25

the same way that she used to care about

113:26

people's opinions when she was 30. One

113:28

of the things I said I noticed about

113:29

myself was after I turned 30. I feel

113:32

like I saw a step change in pattern

113:34

recognition and like exactly what you've

113:36

just described there which is like

113:37

crystallized knowledge cuz I sit here

113:39

with experts all day learn all this

113:41

stuff from them and then my ability to

113:43

then like apply it in my life as an

113:44

entrepreneur seems to be improving. And

113:47

so the question I was really going to

113:48

ask you is you think about

113:50

entrepreneurship lot my a lot of my

113:51

audience are entrepreneurs in some

113:53

capacity or aspire to be. I was

113:55

wondering as you were saying that like

113:56

when is the best age because

113:58

entrepreneurship is a lot about pattern

114:00

recognition. It's problem in front of

114:02

you. Okay, I've seen this before. I'm

114:04

pulling on different reference points to

114:05

arrive at a solution. So I was wondering

114:08

here because it looks like it peaks at

114:09

like 45.

114:11

>> 45. So if we look at it, it's peaking at

114:14

45. And that's also why a lot of

114:16

biologists continue to do great work in

114:18

their midlife as well. And that is

114:21

something that I do feel like better for

114:23

me as well. you know, where I'm I'm now

114:25

able to pull on I have so much of a

114:27

database in the back of my head, you

114:29

know, where it's like I I've got all

114:31

this knowledge and then it comes up and

114:32

you can use it. And so it's interesting

114:34

you can talk about entrepreneurs, but

114:35

you can I mean any any sort of career

114:38

path, right? What it would be beneficial

114:39

to be able to do that. So the question

114:41

is then how do we get here's peak span

114:44

you're going up and what you want to do

114:45

is you want to get and maintain about

114:48

90% of all these things that we're

114:50

talking about peaking right we immune

114:52

aging it peaks at you know immune aging

114:55

actually peaks around adolescence I

114:56

think muscularkeeletal health 20 25 the

115:00

fluid int intelligence 2025 you're

115:03

having cardiorespiratory fitness that's

115:04

also 20 to 25 it peaks and then it goes

115:07

down the question is how do Do you

115:12

maintain your peak span? Right? How do

115:14

you get as close as you can? You're

115:16

obviously not going to be your 100%. But

115:18

how do you not drop below 90% of that

115:20

peak, right?

115:21

>> Is that possible?

115:22

>> Is it first of all, is it possible? And

115:24

I would say for some organs, no. Which

115:27

organs are that? I don't think a

115:28

reproductive life expectancy for a

115:30

female I don't think you're going to be

115:32

having babies at 80 years old um without

115:35

actual medical intervention but that's a

115:38

whole other conversation. So I but I do

115:41

think there are ways that we can get

115:43

really close to our peak for

115:45

cardiorespiratory for muscle skeletal

115:48

you know for our our intelligence

115:50

cognitive intelligence as well as our

115:52

immune system and I think there are

115:55

blanket things that we could do that

115:57

affect multiple systems right like and

115:58

there's also targeted things so we

116:00

talking about fluid versus cognit versus

116:02

crystallized intelligence right

116:04

obviously crystallized intelligence you

116:06

know it doesn't peak until mid-4s you

116:09

the things that you can do to improve

116:11

crystallized intelligence also improve

116:13

your fluid intelligence. What are those

116:15

things? One, exercise number one thing.

116:17

Aerobic exercise is increasing brain

116:20

derived neurotrophic factor. Very

116:22

important for both these aspects. It's

116:24

also, you know, growing new neurons,

116:26

making connections between the neurons,

116:27

making your brain more plastic and

116:29

adaptable so it adapts to the changing

116:31

environment. Top thing that you can do.

116:33

Another thing that you can do that's

116:34

really important for brain aging is the

116:36

omega-3. We talked about that. really

116:38

important for brain aging. But the other

116:40

thing that you can do is what we're

116:42

doing right now. Engaging in novel

116:45

cognitive, you know, experiences. It

116:49

could be a discussion. It could be your

116:51

work. If you are learning new things,

116:54

novel is key here. Novel. If you're

116:56

learning new things, you are going to

116:58

really help yourself improve both your

117:00

fluid and crystallized intelligence. And

117:02

so,

117:03

>> is that because you're raising your

117:06

potential? i.e. So you're falling from a

117:09

higher place as you decline because I

117:11

was thinking about this like how much of

117:12

this has got to do with making sure that

117:14

I I peak at a higher place

117:17

>> right yeah I mean I think that maybe has

117:20

something to do with it but in addition

117:22

there's neurochemical things that are

117:23

changing when you're learning new

117:25

experiences for one you are increasing

117:27

brain drive neurotrphic factor and stuff

117:29

as well because novelty does that you're

117:31

also glutamate and you're h you're

117:34

having you know glutamate being

117:35

activated as well But um yeah, I think

117:38

the cognitive reserve is what you're

117:39

talking about and that is really

117:40

important, right? Because you you need

117:42

to you need to have that reserve if

117:44

you're going to start pulling from it.

117:45

And that also comes with muscle muscle

117:47

health, right? Muscle and bone. So those

117:49

are peaking around the same times 25 or

117:51

so. Peak muscle mass generally occurs

117:54

around the age of 25. There are things

117:56

that you can do to keep close to that

117:59

peak though, right? And that would be

118:00

resistance training, big big one.

118:03

Strength training. Strength goes down.

118:05

This is something protein intake, right?

118:08

>> Avoid the black plastics in my fridge.

118:10

>> Avoid black plastics in your fridge.

118:11

Yeah.

118:12

>> Because then my testosterone is going to

118:13

go down.

118:13

>> Testosterone is going to go down and

118:14

that's going to affect your ability to

118:16

gain muscle mass. Exactly. A a lot of

118:19

these healthy lifestyles that we're

118:20

talking about are multi-system

118:22

targeting, right? So, you're targeting,

118:24

but key would be strength training and

118:26

resistance training. And it's going to

118:27

also affect your bones. So, you're going

118:29

to want to do these weight bearing

118:30

exercises that are multi- joint, the

118:32

compound lifts, right? the deadlifts,

118:34

rows, things like that. Those are very

118:37

important to help maintain that peak.

118:39

Immune system, sleep, very, very

118:41

important for maintaining a healthy

118:44

immune system and preventing your immune

118:46

system from aging rapidly. So, making

118:48

sure you're prioritizing sleep, how you

118:51

going to do that, right? I mean, there's

118:52

a lot of ways to people people a lot of

118:55

people have sleep problems and they have

118:57

sleep problems for different reasons and

118:59

there's way to ways to target them. But

119:01

just realize thinking about it and

119:03

prioritizing is important for your

119:04

immune system and for your brain. Also

119:06

the exercise plays a role in your

119:08

cardiorespiratory fitness, the brain,

119:10

everything, muscle. So cardiorespiratory

119:12

fitness is something that you we talked

119:14

about uralithn helping improve it on top

119:16

of exercise. So there's supplements and

119:18

stuff that you add in as well. But this

119:20

idea here is really that we can do

119:23

things in our life that are healthy to

119:25

help maintain that peak span to get us

119:27

not just free of disease but like close

119:30

to what we were peing. And I do think

119:32

it's possible. I mean we talked last

119:33

time I was here we talked about that

119:34

study you exercise 5 hours a week do

119:38

some highintensity interval training in

119:39

there and you can reverse heart aging by

119:41

20 years. That's incredible.

119:43

>> It's so crazy. So,

119:46

>> and you're also saying that listening to

119:47

the diary of a sea obviously is

119:49

therefore good for

119:51

>> Yeah. It's good for cognitive um your

119:54

fluid intelligence and your your

119:55

crystallized intelligence. It's good for

119:57

learning new things, right? I mean,

119:58

that's

119:59

>> So, you would prescribe it.

120:00

>> Yeah.

120:00

>> Yeah. Especially the episodes I'm on.

120:06

No, I say that as a joke, but actually

120:08

it's part of the conversation we had the

120:09

other day at dinner was I don't think

120:11

I'm going to appreciate maybe until

120:14

later in my life how much an unintended

120:16

consequence of doing this as a job had

120:19

on my cognition and my brain

120:23

and it's like not something that I would

120:24

notice you know in the moment but over

120:26

time you know doing this two times a

120:28

week for sometimes eight hours a week

120:30

learning something new being forced is a

120:32

strong word but having an obligation to

120:34

learn something new for eight hours a

120:36

week for my entire adult life.

120:38

>> It's great. I mean, it's it's one of the

120:41

best things that you can do for your

120:42

brain. That's why learning a new

120:43

language is associated with a rapid, you

120:46

know, decrease in Alzheimer's disease

120:47

risk.

120:48

>> You're working your brain. You're

120:49

learning new things. It's so one of the

120:52

worst things that someone can do is

120:53

retire

120:54

>> and just sit and watch TV, right? I

120:57

mean, that's like the worst thing.

120:58

You're gonna you're rapidly going to

120:59

decline and get dementia.

121:01

>> We've got to talk about AI in this

121:02

conversation.

121:03

>> Oh my gosh. because I actually woke up

121:06

this morning and I got a message. Look,

121:08

I'll check with him that I can put this

121:09

in before I say out before um it's

121:11

published. But I got a message from my

121:13

chairman, Nikki. Um Nikki is an

121:15

incredible man. He's, you know, 25 years

121:17

bossing consulting group. He's seen it

121:19

all. Um, and he said to me that one of

121:22

the things he's thinking a lot about at

121:24

the moment is how across our, you know,

121:26

businesses, but just generally in

121:27

society, how AI is going to impact

121:30

critical thinking and what that then

121:32

might mean for our teams, our

121:33

executives, etc. So, this is a

121:35

conversation I was having this morning

121:36

with him. And it's also something I've

121:38

noticed. There are certain people I

121:40

interact with now where I I do not feel

121:42

at all like I'm dealing with their

121:44

brain. I feel like I'm dealing with what

121:46

came out the other end of a chatbt

121:47

prompt.

121:49

Yes.

121:49

>> Good, bad, and different. Like I don't,

121:50

you know.

121:51

>> Yeah. It's it's an interesting and

121:53

important question, Stephen, because

121:54

I've been thinking a lot about

121:58

what with AI, it's changing so much. And

122:00

the question is like, do you focus on,

122:03

you know, the negative parts and the

122:05

short-term parts? Do you focus on the

122:07

potential benefits that could be great

122:09

and grand? And I do I do think a lot of

122:11

it is people are worried about things

122:13

like, oh, AI is going to take all of our

122:15

jobs. Oh, we're going to have brain rot

122:16

because we don't use our brains anymore.

122:18

And and those are concerns to have, but

122:21

there's also a lot of exciting things to

122:23

think about. I also worry about the the

122:25

brain rot part where it's like, well,

122:27

okay, these people aren't critically

122:29

thinking for themselves. I've seen

122:32

comment. I can I can spot AI a million

122:34

miles away, a million miles away, right?

122:36

And and you know, part of it is if AI is

122:40

accurate and they're and people are e

122:42

more easily accessing the in accur

122:44

accurate information and they're

122:46

learning it, that's great. Like that's

122:48

what it's supposed to be there for,

122:50

right?

122:50

>> I think that's a big if, right?

122:52

>> If right if and and it does have a lot

122:55

to do with the version of AI you're

122:57

using. It has a lot to do with the

122:59

prompt. It has a lot to do with the

123:00

question, how much, you know, reasoning

123:03

it has to do. I mean, there's we're it's

123:05

still evolving, but I agree. It's kind

123:08

of like the worry is are are we going to

123:11

have a generation of of people growing

123:13

up that don't know how to critically

123:15

think.

123:16

>> You've heard about that London taxi

123:17

driver test experiment. I think I've

123:19

heard you talk about it before,

123:20

actually.

123:21

>> Yeah. I mean, well, they have these maps

123:23

in their heads, right? And you have

123:24

these taxi drivers in London that um

123:27

they don't use GPS. Like, they know

123:30

everywhere to go. By the way, I was in

123:31

London a couple of years ago. I love the

123:34

taxi drivers there. They are so awesome.

123:36

Like they are just different. They're

123:38

totally different than

123:39

>> For anyone that doesn't know, I'm

123:40

absolutely going to butcher this. To

123:42

become a London taxi driver, you have to

123:44

take a test for many, many years. You

123:46

have to learn for many, many years, and

123:47

you have to learn like every street

123:49

across London from the top of your head

123:52

without using GPS.

123:54

>> So that's incredible.

123:55

>> So yeah, when you get in a black cab in

123:56

London, it's amazing. You can go, I kind

123:57

of want to go to and they go, got you.

123:59

>> They know everywhere. They have maps in

124:01

their brain. I mean, think about the

124:02

cognitive reserve they have. Think about

124:04

the like all the things they learned and

124:07

what and the spatial memory and all

124:09

that. And um do these do these guys ever

124:12

get Alzheimer's disease? I don't know

124:13

that they do. I mean, there's studies

124:15

out there showing that these these types

124:17

of um taxi drivers like do not get

124:19

Alzheimer's disease.

124:20

>> They have to learn 25,000 streets and

124:23

it's called the knowledge and they have

124:24

physically larger hippocampus centers in

124:27

their brain which is the memory center.

124:29

And I like to extrapolate if I may and

124:32

think that all this cognitive learning

124:34

that I do daily and that you're doing by

124:36

like talking to guests from all sorts of

124:38

fields is also very I mean you're

124:40

learning things. It's not just going

124:42

you're you're interested in things and

124:43

you're learning them and it really is

124:46

also a type of brain exercise. And so I

124:49

think that this is ultimately what we

124:51

were getting to is basically we're gonna

124:54

talk about AI because I know we got to

124:55

get there but is essentially like if you

124:57

can engage in intellectual types of

125:00

activities or anything that's going to

125:02

exercise your brain whether it's

125:04

learning the map of London or it's

125:06

learning about mphagy whatever it is you

125:09

know it's really good to engage in that

125:12

novel learning it's really good for your

125:13

brain it's working your brain out

125:15

>> I've been thinking a lot about this I've

125:16

just come back from South by Southwest

125:18

and every conversation was about bloody.

125:19

I was there too.

125:19

>> I really they were asking me a lot about

125:21

AI. So before I went on stage I was

125:23

looking at some of the studies and I

125:25

concluded that at the moment we are in

125:27

society there's going to be a bit of a

125:28

bifocation of people. One group is going

125:31

to do take the path of least resistance

125:33

with AI which is they're going to defer

125:35

their thinking to AI which is you know

125:37

one of the things I learned from people

125:38

like you often is that if you don't use

125:40

it you lose it and that part of their

125:42

brain whatever it is will begin to

125:44

atrophy to some extent. And I think

125:45

there'll be another group of people who

125:46

will just like we go to the gym now

125:48

because we have to because our lives are

125:50

so easy. They will go to like the mental

125:52

gym which means they will set aside time

125:54

to intentionally solve difficult

125:56

cognitive problems or or challenges. And

125:59

I've I literally have said to some of my

126:01

executives, we'll have a moment where

126:03

we're talking on WhatsApp or Slack and

126:05

I'll literally say, let's try and solve

126:07

this problem with our brains because I

126:09

believe that solving this problem with

126:10

our brains will create a deeper

126:12

understanding of the first principles of

126:14

the problem. Not the just surface level

126:16

1 plus 1 equals 2, but like what is one?

126:19

>> What is a number? And this is the

126:21

difference like I AI can like give you

126:23

the answer, but it's not going to give

126:25

you the foundation so that you can solve

126:26

other problems in the future. Because if

126:28

I never told you what the number one

126:29

was, you would never in the future be

126:31

able to use it yourself. All you would

126:33

know is 1 plus 1 equals 2. But there's

126:35

foundations like what are numbers, what

126:36

is 1, what is 2, what is plus that you

126:39

need to understand to be able to do 1 +

126:41

2 equals 3. Um, and the study, one of

126:44

the studies I looked at which was has

126:46

been heavily discussed was from last

126:48

year, I found staggering memory cost

126:51

using generative AI. In this study,

126:53

which I'll throw up on the screen, 83%

126:55

of AI users were unable to remember the

126:58

details of a passage of text that they

127:00

had written with AI's assistance. EEG

127:04

scans showed that brain connectivity was

127:06

almost halfed when individuals

127:08

outsourced their thinking to AI compared

127:10

to writing manually, which created

127:12

cognitive debt. You get output faster,

127:15

but you don't build the long-term neural

127:17

hardware to understand the information

127:20

or the knowledge.

127:21

>> So true. It's so true. You know what's

127:24

interesting about what you just said is

127:25

the when you're writing something,

127:28

whether you're typing it or even

127:30

actually the most I think there's been

127:32

some studies on this like handwriting

127:34

something,

127:35

>> something about handwriting it really

127:37

ingrains it into your memory. And I have

127:39

this process when I'm trying to there's

127:41

a lot of facts that I have to remember,

127:44

you know, when I'm talking about them.

127:46

And I have this process that I do. And

127:48

the first one is the research, right?

127:50

you research it and you find it and then

127:52

I type it in a Google doc

127:55

>> and then I write it

127:56

>> and that process is really what gets it

128:00

into my memory all the like statistics

128:02

and you know think statistics are always

128:04

harder because it's just a number

128:06

>> you know versus like you like you're

128:08

saying you're understanding the

128:09

fundamental nature of something that I'm

128:12

interested in that always helps and so

128:15

it's interesting that if you're if

128:17

you're writing something if you're

128:18

writing it like typing it or writing it,

128:21

handwriting, they're probably talking

128:22

about typing it. Even that really does

128:24

help you remember something. If you're

128:27

just copying it and then trying to do

128:29

some recall,

128:31

it's not going to it's not going to

128:33

work. And then there's the whole other

128:34

layer that you were talking about, which

128:36

is like you're not even using the

128:38

novelty isn't there. You're not like

128:40

really into it and learning. And that's

128:43

what it really takes to build that

128:45

cognitive reserve to improve the

128:47

connections to increase brain derived

128:49

neurotrophic factor, right? You need

128:50

that novelty. So I do love AI, but I

128:54

also know that um I need to continue

128:58

using my brain and I have my own

129:01

protocols that I like and that I still

129:03

do. I still write things down. I have a,

129:06

you know, I have my little notebook and

129:08

I when before I go on a podcast too, I

129:11

like to go through and write stuff down

129:13

that I've already typed that I've

129:14

learned and things I wanted to cover. It

129:17

really makes a difference in memory. So

129:20

for people that are like you and I and

129:22

learners and optimizers, I keep take

129:25

take that take that pointer because it

129:27

really does work.

129:28

>> This was one of my favorite things with

129:30

the iPad. Listen, I'm not the type of

129:31

person that does a huge amount of

129:33

writing on pen and paper. Although I

129:34

would do more because everything you've

129:36

said is proven to be true for me. If I

129:37

write something down, it's like I'm

129:38

writing it directly into my brain,

129:39

>> right?

129:40

>> But the iPad now allows you to split

129:42

what you're reading in terms of a book

129:44

on one side and then a notepad on the

129:47

other. So what I do when I read is I

129:50

read the thing and then I try and write

129:52

out the lesson on the other side of the

129:54

page. So I'll say the gut microbiome has

129:56

42 trillion bucks. And I'll go the gut

129:58

microbiome has 42 million bucks. I love

130:00

it. I love it.

130:01

>> And then I turn the page and I I'm so

130:03

I'm trying to do exactly what you said

130:04

because I realized that a lot of stuff I

130:05

learned doesn't land unless

130:07

>> right

130:08

>> I write it out myself.

130:09

>> It's something about the act of writing

130:11

>> and if you add the layer of like what I

130:13

do it takes time you know so you have to

130:15

type it and then write then it really

130:17

sticks in your brain. Like those are the

130:18

ones when I've done those are the ones

130:20

that really have stuck if I've done them

130:21

both. But I love that I don't use iPads

130:25

ever and I still like read books, you

130:27

know, like old books and when I have

130:29

time to do them and I just have my

130:30

notebook.

130:30

>> I think it shows though you you you have

130:32

an unbelievable ability to remember so

130:34

many things.

130:35

>> But I still love AI, you know, I still I

130:38

think there's a lot of benefits and I

130:39

and I think that, you know, scientists

130:40

in general are using a AI is now their

130:45

collaborator, right? They're they're

130:48

pretty smart collaborator that has

130:50

access to a lot of data and can analyze

130:52

a lot of data quickly.

130:54

>> What are your thoughts on exercise and

130:55

the current suggestions and

130:56

recommendations around exercise?

130:59

>> Well, I'm glad you asked this question.

131:01

I think I've been thinking about this a

131:03

lot. I did a podcast on the current

131:04

exercise guidelines and I think they

131:06

need to be updated. I think they're

131:08

they're not good enough. And and it's

131:11

important for people to realize how

131:13

these extra exercise guidelines were

131:14

formulated and what they mean. So

131:16

typically you'll hear exercise

131:18

guidelines 150 to 300 minutes a week of

131:21

moderate intensity exercise is good for

131:23

optimal health or 75 minutes to 150

131:26

minutes a week of vigorous intensity

131:29

exercise. Right? So they're basically a

131:31

2:1 ratio, right? Twice as many minutes

131:34

for for moderate intensity as vigorous

131:36

intensity. What is defined as moderate

131:39

versus vigorous? That's also important

131:40

because it's different across different

131:42

studies. In these guidelines, it's

131:45

basically moderate intensity is you're

131:48

walking. You're moving with intent, but

131:50

not really really fast. You're walking.

131:51

You're walking at maybe a fast pace, but

131:53

you're not jogging, you're not running.

131:56

That kind of activity would be

131:57

considered moderate. Vigorous would be

131:59

considered jogging, running, swimming,

132:02

cycling. So the the kind the kind of

132:05

activity where you're actually moving

132:06

fast with intent.

132:08

Why do we have this 2:1 ratio? Where did

132:11

it come from? Well, it all came from

132:13

energy expenditure. You burn twice as

132:15

many calories if you're doing vigorous

132:18

intensity exercise as you do if you're

132:19

doing moderate intensity. Right? So if

132:21

you're walking one mile, you'll burn x

132:24

amount of calories. If you jog that

132:27

mile, you'll burn twice as many

132:28

calories. That's where these guidelines

132:29

came from, the 2:1 ratio, right? weight

132:32

loss, energy expenditure, but that's not

132:35

necessarily what's important for

132:37

reducing cancer mortality, reducing

132:39

cardiovascular related mortality,

132:40

reducing all cause mortality. Right?

132:43

These guidelines used that data, this

132:46

2:1 ratio of energy expenditure, and

132:50

then they looked at other studies and

132:52

said, okay, how much exercise is

132:54

required to reduce cardiovascular

132:56

related mortality or all cause

132:58

mortality? And they kind of like

132:59

connected the dots. By the way, these

133:01

studies also were using um

133:04

questionnaires. They weren't actually

133:05

measuring how active people were. A new

133:08

study came out and I did a journal club

133:10

podcast on it because it was a study

133:12

that I felt was so important that we

133:14

wanted I wanted to break down all the

133:16

components of the study with um another

133:18

scientist and talk about them because

133:21

it's very important. So journal clubs

133:22

typically in science you have them in my

133:26

career it was you know sometimes it was

133:28

once a week other times it was once a

133:30

month and and someone you choose a study

133:32

that's important and you break it down

133:33

and you talk about the results and you

133:35

talk about the methods and you talk

133:36

about what the findings mean that's what

133:38

a journal club is and it's essentially

133:40

you choose a a journal and a publication

133:42

within that journal and it's a it's a

133:44

club you have different scientists that

133:46

are talking about it

133:47

>> why did this warrant a journal club

133:49

>> because I think this study bas basically

133:53

is is strong enough data that it's

133:56

implying we need to change our exercise

133:58

guidelines, at least the messaging of

134:00

them at the very least. And I'll tell

134:02

you why. Because I talked about these,

134:04

you know, these guidelines, how they're

134:06

formulated. They're using

134:08

questionnaires. They're not measuring

134:09

anything. Well, a new study came out.

134:10

Not only did it measure physical

134:12

activity through these accelerometers,

134:14

it was able to measure how active people

134:15

were and the type of activity whether it

134:18

was I I mentioned moderate versus

134:20

vigorous, they also me they also

134:21

measured light physical activity that

134:23

would be considered walking around your

134:25

house kind of doing that kind of light

134:27

activity, not necessarily going for a

134:29

walk or going for a run. And they looked

134:33

at deaths from different causes of

134:35

disease. They looked at deaths from all

134:37

causes. So all cause mortality, they

134:39

looked at cancer related deaths, they

134:41

looked at cardiovascular related deaths,

134:43

they looked at type2 diabetes, they

134:44

looked at heart attacks, right? And what

134:47

was so profound was that what we found,

134:50

what they found and what we now know is

134:52

that everything changes in terms of how

134:55

important vigorous intensity exercise

134:57

is. It's so much more valuable than we

135:00

thought. It's not 2 to one. So if we're

135:02

looking at all cause mortality, you

135:04

know, dying from all causes, cancer,

135:06

respiratory, anything related that's

135:07

non-acal,

135:09

for every one minute of vigorous

135:10

intensity exercise, you had to do 4

135:12

minutes of moderate intensity and you

135:15

had to do like 100 to 150 minutes of

135:17

light exercise to get the same reduction

135:20

in all cause mortality.

135:22

>> For every one minute,

135:23

>> for every one minute of vigorous

135:24

intensity exercise, it gets better.

135:27

Okay? For every one minute of vigorous

135:29

intensity exercise to reduce your death

135:31

from cardiovascular disease, you had to

135:34

do eight minutes of moderate intensity

135:36

and 200 minutes of light exercise. For

135:39

every one minute of vigorous intensity

135:42

exercise, it's huge. to reduce your type

135:44

two diabetes risks. For every one minute

135:47

of vigorous, you had to do 10 minutes of

135:50

moderate intensity or you had to do

135:52

again you're in the 100 150 minutes to

135:55

200 minutes of light exercise to reduce

135:59

your risk of dying from cancer. For

136:01

every one minute of vigorous intensity

136:03

exercise, you had to do four minutes

136:04

about four minutes of moderate

136:06

intensity. And for light, it was like I

136:09

it was almost not not even happening. I

136:11

mean it was like 250 300 like you had to

136:13

just a ton of minutes unbelievable

136:16

amount of minutes. Okay. But the the

136:18

value of vigorous intensity exercise is

136:21

so much more than this 2:1 ratio based

136:25

on energy expenditure based on burning

136:27

calories that our guidelines were based

136:29

on. It's time to rethink them. It's time

136:32

to tell people, hey, if you're getting

136:34

out and you're going for a run, it is

136:36

worth way more than you think it is in

136:38

terms of reducing your disease risk and

136:40

your death from that disease. Right?

136:42

Also, what was really interesting about

136:44

this study, and this goes back to this

136:46

exercise snacks that we talked about

136:48

before last episode, is that because

136:51

there people were participants were

136:53

wearing these accelerometers on their

136:54

wrist, they were able to measure all

136:58

physical activity. Let's say you're you

137:00

have a new puppy and you're sprinting in

137:02

the yard and playing with them for a

137:03

minute or two minutes or three minutes

137:04

or whatever. Not 30 minutes in the gym,

137:06

right? Or not 30 minutes on the

137:07

treadmill, but you're just a short burst

137:09

or you're playing with your grandkids or

137:10

your kids and you're playing tag,

137:12

whatever. Those moments count. They

137:14

really add up. And that is also a

137:16

take-home from this study and other

137:18

studies is that you can actually get

137:20

massive benefits from the sprinting, the

137:22

vigorous exercise. One minute, two

137:25

minute, three minutes. Women that did

137:27

three and a half minutes of just this

137:29

vigorous types of exercise per day

137:31

lowered their cancer risk by 40%.

137:34

Yes, three and a half minutes a day.

137:36

This was in women. Now there's bigger

137:37

studies showing men and women that

137:39

exercise 9 minutes a day. The short

137:41

vigorous types of exercise adding up not

137:44

9 minutes altogether, but like a minute

137:46

here, a minute there, a minute here,

137:47

right? It adds up 40% lower cancer

137:50

related mortality, 50% lower

137:52

cardiovascular related mortality. And

137:53

that's another big takehome from this

137:55

study that I really want people to know

137:57

about because some people don't like

138:00

spending 30 minutes or putting out

138:02

blocking out a 30 minute time or an hour

138:04

long time to go to the gym. They should.

138:06

I mean, if they want their peak span,

138:07

that's what you're going to have to do.

138:09

But if you're just wanting to avoid

138:10

disease and be be your health span, you

138:13

know, you can get that by doing these

138:15

short moments of short bursts of

138:18

physical activity and those count. And

138:20

some people are like, "Oh, thank God.

138:22

Thank god I can do that because I hate

138:24

going to the gym. I'll, you know, they

138:26

just won't do it. They won't do it.

138:28

>> A lot of people as well are caught up

138:29

with this 10,000 steps a day thing.

138:31

>> Yes. 10,000 steps a day.

138:33

>> What's that facial reaction for people

138:34

that can't see your face? She looked up

138:35

into the corner like I personally

138:37

offended her.

138:38

>> Yeah. I look, any exercise is better

138:41

than none. I want to just get that on

138:42

the table. Okay. That's important. I

138:44

don't want to totally diss the 10,000

138:46

steps a day, but I think that we need to

138:48

ditch it. I think we need to ditch

138:50

10,000 steps a day and say 10 minutes a

138:52

day. 10 minutes a day of getting your

138:54

heart rate up. You can you can you can

138:56

do body weight squats. You can, you

138:58

know, play tag with your kids or your

139:00

grandkids. You can do shorter bursts of

139:03

it, but it needs to be 10 minutes. And

139:05

if you get to that 10 minutes a day, 50%

139:07

lower cardiovascular related mortality,

139:09

50% lower all-c cause mortality, 40%

139:12

lower cancer mortality. That is what

139:14

you're going to get. 10,000 steps a day

139:16

is not going to get you that. We just

139:18

talked about it. It's not going to get

139:19

you that, right? It's a different ratio.

139:21

It's not 2 to1 ratio.

139:23

>> I imagine there's people thinking you

139:24

use three terms there. Vigorous,

139:25

moderate, and light. We probably need to

139:27

quite clearly define those definitions

139:30

like what is vigorous,

139:31

>> right?

139:31

>> Heart rate is it or

139:33

>> vigorous intensity exercise can be heart

139:35

rate and it is heart rate. In a lot of

139:38

studies that are done in terms of the

139:41

exercise guidelines, they don't use

139:43

heart rate. They're using movement. Like

139:45

when I say accelerometer, I mean moving

139:48

fast. So they're able to measure the

139:50

acceleration of your movement. And so

139:52

the way that they're talking about it in

139:54

these in these exercise guidelines

139:56

studies is moving fast. Moving fast

139:59

would be jogging, running, swimming,

140:03

biking. You're moving even

140:04

>> stepper.

140:05

>> Stepper would would with stepper would

140:06

be moving fat. Even even weights are

140:08

moving fast. That's part of it too.

140:09

Weights you're doing you're doing

140:11

weights

140:11

>> weight

140:12

>> because you're because they're on your

140:13

wrist. And so if you're if you're doing

140:15

bicep curls or you're doing, you know,

140:17

something with your with your wrists

140:18

that are fast, it's part of that it's

140:20

part of that equation as well.

140:22

>> Heart rate isn't the thing that we're

140:23

measuring, but that's a consequence of

140:24

moving fast. Typically, it is.

140:26

>> So you want to be thinking about getting

140:27

your heart rate.

140:28

>> Personally, when I think about it, and

140:30

if I'm talking about in the context of

140:31

these exercise guidelines,

140:34

I would say that heart vigorous would be

140:36

probably considered 70% or more of your

140:38

max heart rate would be considered

140:40

vigorous. Previously in my when I'm

140:42

talking about vigorous I also talk about

140:44

highintensity interval training and

140:45

that's more like 80% of your max heart

140:48

rate or higher very important for

140:50

improving V2 max and cardiorespiratory

140:53

fitness but in these studies heart rate

140:55

was is more like a 70% your max heart

140:58

rate and more because that's you can be

141:00

jogging at that rate right jogging or

141:02

running that's a big that's vigorous

141:04

intensity exercise if you're below that

141:06

if you're like you know 50% your max

141:09

heart rate that's considered moderate

141:10

intensity and then you know maybe even

141:13

lower than that if you're just sort of

141:15

you know walking around the house. I

141:18

mean that's not even going out much at

141:19

all. That's light. That's considered

141:21

light. 10,000 steps would be probably

141:24

considered it depends because actually

141:26

they're saying steps which means could

141:28

just be around the house. If you walk

141:30

around your house, how long does it take

141:32

to do 10,000 steps? Like an hour, hour

141:36

and a half.

141:36

>> Yeah, probably just doing six or 7,000

141:38

just walking around the office. So, but

141:40

that's considered light exercise.

141:42

>> So, that's why I think we need to get

141:44

rid of that. It's not enough. It's not

141:46

enough. It's better than sitting because

141:49

sitting is bad. Sitting is an

141:51

independent risk factor for disease, for

141:53

cancer in particular.

141:54

>> This was one of the most replayed

141:56

moments last time I spoke to you was

141:58

people replayed the section where you

142:00

talked about being sedentary and how

142:02

much of an issue that is for all of us.

142:04

And it's really stayed with me to the to

142:05

the fact I don't know if this helps but

142:07

I've been using standing desks

142:08

everywhere. Even when I travel around

142:10

the world now I've actually got a

142:11

portable standing desk just to try and

142:13

keep me up because as a podcast I I've

142:15

sat in this chair for what I've sat down

142:17

for six hours today and it's 3 p.m.

142:20

>> Right. Yeah. Uh Kelly Starret wrote a

142:22

book Deskbound some years ago and you

142:24

know he really played a role in

142:25

popularizing this this idea and I think

142:27

in the public um as well being sedentary

142:31

is time you're you're spent sitting

142:33

right time you spend sitting it doesn't

142:35

necessarily mean I used to think about

142:37

being sedentary as oh do you work out

142:39

yes or no you're sedentary yes no you're

142:42

not sedentary that's not what sedentary

142:45

is sedentary is time you're spending

142:48

sitting we've been sitting here quite

142:49

quite a few course we've been sedentary

142:51

this whole time. So being sedentary and

142:53

sitting is an independent risk factor.

142:56

Even if you're exercising, it's an

142:57

independent risk risk factor for

142:59

diseases. I mentioned cancer in

143:00

particular. That seems seems to be the

143:02

one that's more strongly correlated to

143:03

being sedentary. But standing standing

143:06

helps if you're standing up or also

143:08

getting up and doing exercise snacks. So

143:10

you can get up every hour and like do

143:12

some body weight squats, do some jumping

143:13

jacks, do some high knees, get your

143:15

heart rate up. That breaks up the

143:17

sedentary time. So now it's only an hour

143:18

of sedentary versus eight hours, right?

143:20

Or six hours or however long you're

143:22

sitting at your desk. It makes a

143:24

difference. And those exercise snacks

143:25

are easy to do. I have a standing desk.

143:28

I don't use it enough. I I still have

143:31

it. I do do exercise snacks. And I like

143:33

doing the exercise snacks because like

143:35

literally if we were to get up and do

143:36

bodyweight squats right now for one

143:38

minute, like you're going to feel

143:39

better. You feel better after the blood

143:42

flow to your brain. It gives you a

143:43

little pump. I love it. I love the pump.

143:45

It's it's just one minute of it and you

143:47

get a short pump to your brain and it

143:49

makes you feel better. So exercise

143:50

snacks are a really good way to break up

143:52

sedentary time. They're also adding up.

143:55

They count as I just mentioned. They

143:57

count towards your exercise goal and

144:00

they're vigorous. You're you're getting

144:01

you're moving fast, right? Vigorous

144:04

exercise. You're getting your heart rate

144:05

up.

144:06

>> Or I could just take a Zen. I just get

144:09

the pen out, jab, jab, jab, and it's uh

144:11

all of this stuff disappears, right? I

144:14

could do all of this stuff or I can just

144:16

zen it, right?

144:16

>> Yeah. I mean,

144:17

>> so many people are taking a Zen. So

144:19

interesting. And I listen, I have to say

144:21

it's saving people's lives. Amazing.

144:23

I've heard so many of my friends who are

144:24

on a Zen and taking the GLP1 pens say

144:28

that they've had profound benefits.

144:30

Their knees are better. They can walk

144:31

upstairs. They feel better.

144:34

>> Yeah. I mean, let's be real here. Being

144:37

obese and overweight is one of the worst

144:39

things you can do for your health,

144:41

right? It's going to accelerate the

144:42

aging process and it's going to increase

144:45

the risk of every age related disease.

144:46

Cardiovascular disease, type two

144:48

diabetes, cancer, you know, visceral

144:50

fats happening. You're insulin

144:51

resistant. You know, it's all it's all

144:53

happening. It's going to affect your

144:54

quality of life. It's harder to walk

144:55

around. You're not as mobile. Your

144:57

joints are getting more stress on them,

144:59

right? So, it anything that can help you

145:02

lose that weight is going to be

145:03

beneficial. And so, these GLP1, you're

145:06

talking about ombic, that's the GLP1

145:08

receptor agonist, right? They are very

145:12

they're life-changing for people that

145:14

are obese, people that need to lose, you

145:17

know, 40 lb, 50 lb, 30 lb. It's not easy

145:21

to lose that weight with diet and

145:24

lifestyle.

145:25

>> Yeah. Well, let's talk about the butts.

145:27

Let's talk about So, the benefits are

145:30

obviously if they're going to lose that

145:31

fat, the visceral fat, they're going to

145:33

become insulin sensitive. They're going

145:35

to reduce their risk for all those

145:36

diseases. And that's what the data

145:37

shows. cardiovascular disease risk goes

145:39

down, cancer risk goes down. Um, except

145:41

for one type of cancer goes up, kidney

145:44

cancer, but you know, the Alzheimer's

145:46

disease risk goes down. Anything that

145:48

you're going to when you lose weight,

145:49

those risks are going to go down. There

145:51

are side effects and there are things to

145:54

consider when you're taking I'm calling

145:56

them GLP-1s because we have first

145:57

generation, sec second generation, and

146:00

now third generation. And they're

146:01

affecting not only the GLP-1 receptor,

146:03

but they're affecting glucagon, for

146:05

example. they're affecting another

146:06

peptide called GIP, GIP. So, I'll just

146:09

call them GLP1s for short. Okay. Um,

146:12

semiglutide or zic is the f one of the

146:14

first generations. We now have the

146:16

second generation that's targeting two

146:18

pathways. You can lose even more weight.

146:19

Marjaro would be something that people

146:21

would relate to. That's this one of the

146:23

second generation ones. And I think that

146:26

for people that are going to start these

146:27

these drugs, first of all, they have to

146:30

realize there's a good chance they're

146:32

going to have to be on them for the rest

146:33

of their lives. And that that's

146:35

something that you have to be willing to

146:37

do. And I say that because

146:39

many studies have shown now that

146:41

individuals that do take these GLP1s do

146:44

lose a lot of weight. And it's very

146:46

beneficial to lose that weight. But if

146:49

they stop taking the GLP1s, they gain

146:51

the weight back and and often oftentimes

146:54

they gain all the weight back because

146:56

your body's kind of trying to go back to

146:57

that reset point and their hunger comes

147:00

back with a vengeance. And so part of

147:02

what GLP-1 drugs are doing are they are

147:05

basically, you know, they're they're

147:07

they're making you feel satiated and not

147:09

hungry. So they're affecting your

147:10

satiety hormone so you don't feel

147:12

hungry. They're also slowing gastric

147:15

emptying so food stays around in your

147:17

intestines longer so you feel full. When

147:19

food is in your intestines, you don't

147:21

feel hungry. So they're slowing that

147:23

process and so people don't feel hungry.

147:25

And so what ends up happening is in many

147:27

ways it's mimicking calorie restriction

147:30

and fasting, right? You're basically not

147:33

eating as much food. So that's

147:35

essentially but it's doing it for you.

147:37

It's not you don't have to put in that

147:38

you don't have to feel hungry. You don't

147:40

have to put in that work and and it's

147:42

doing it for you, right? And so people

147:44

are losing a lot of weight and they're

147:46

losing it very rapidly. And I said you

147:49

might have to be on it for the rest of

147:51

your life. And what I what I mean by

147:52

that is because a lot of studies show

147:54

that majority of people do gain back

147:56

their weight. Their appetite comes back.

147:57

It comes back with the vengeance and

147:59

they they regain the weight over over a

148:01

year or so. So that's one thing to

148:04

consider. Are you willing to take it for

148:06

the rest of your life?

148:07

>> There was a a New York Times piece where

148:09

they looked at a lady called Stacy

148:10

Canterbury. She had lost 50 pounds on

148:13

one of the GLP ones that you mentioned,

148:15

reaching her peak goal weight. And after

148:17

stopping the drug due to insurance

148:18

issues, she regained 20 pounds back

148:21

straight away in a month. Interestingly,

148:23

she described the return of hunger not

148:24

as a gradual increase, but as a

148:27

ferocious, anim animalistic urge to eat.

148:31

That was far more intense than before

148:33

she ever started the medication. And the

148:36

New York Times did a big piece about

148:37

that because one of the things that I've

148:39

come to learn is that there's no free

148:40

lunch in life. No pun intended.

148:42

>> There's no free lunch. There's no free

148:43

biological lunch. It's it's true. Um

148:46

yeah, people's appetite, that's why I

148:47

said it comes back with the vengeance

148:49

because it seems to be the case where

148:50

your body's like it hasn't been hungry.

148:52

And it's like, wait a minute, I've been

148:54

starving for so long. I need to eat.

148:56

Right? So it's kind of like feed me. And

148:58

that's that's obviously something to

149:00

consider. So the question is, well, what

149:02

happens if you're on these drugs long

149:04

term? And you know, we've got these

149:06

drugs early early versions of them have

149:09

been around. They they also help treat

149:10

type two diabetes, right? That's part of

149:12

like they where they first came from.

149:14

They've been around a while. We do have

149:15

some data. Mostly the data is positive

149:18

because people are losing a lot of

149:19

weight and that is what's putting them

149:21

at a high risk for these diseases. And

149:23

so when you lose that weight, it what

149:25

ends up happening is your disease risk

149:26

for all these diseases goes down, right?

149:29

So it's hard to uncouple weight loss

149:31

from what the drug's doing itself. But

149:34

there are side effects in addition to

149:36

that, right? Nausea, GI upset, all that

149:38

stuff. Maybe temporary. Some people it

149:40

kind of sticks around. Some other

149:43

effects I think that are are that people

149:45

are a little more concerned about are

149:47

the um muscle loss and bone loss. That's

149:50

a big one. And that is probably

149:52

something coming from just rapid weight

149:55

loss and and not eating enough food and

149:57

not resistance training. So when you're

149:59

when you're largely fasting throughout

150:02

the day, if you're not getting enough

150:03

protein, then your muscle is not going

150:05

to have amino acids to help, you know,

150:07

basically keep growing. And not only

150:09

keep growing, not use its own amino acid

150:11

reserve for making protein, right? So

150:13

you break down muscle. In fact, there's

150:15

weight loss studies showing that in any

150:16

weight loss diet, you know, if you're

150:19

not eating enough protein and you're not

150:20

resistance training, up to 40% of your

150:22

weight can come from muscle weight loss

150:24

that you're losing. I should say lean

150:26

mass, including muscle. So that's a

150:28

little different, but it's it's a big

150:30

percent, right? And so you're talking

150:32

about losing a lot of muscle as well.

150:34

And that is something that happens with

150:35

these drugs. If people are training,

150:38

it's really helps. If they're resistance

150:40

training, it's really helping because

150:41

that's a signal to to your muscle to

150:44

grow muscle. It's a mechanical force

150:45

that helps you grow muscle, right?

150:47

That's something to consider. Bone loss

150:48

is another one. You can also lose bone

150:51

from rapid rapid weight loss. I don't

150:54

know if there's an independent like

150:56

GLP-1 receptors that are on bone doing

150:58

something directly there yet to be

151:01

uncovered. I think we don't really know

151:04

why bone loss occurs. It's thought maybe

151:06

it's just the weight loss, but like I

151:08

said, maybe there's something that we

151:10

don't understand yet. Kidney cancer is

151:12

another one. It seems like there's an

151:14

increased signal for kidney cancer.

151:15

Don't know why that is. Needs to be

151:17

studied. There's a blackbox warning on

151:20

them for thyroid cancer increase. that's

151:23

never really been shown in human

151:25

studies. It all comes from animal data,

151:27

but it's there nonetheless. Something to

151:29

consider

151:29

>> and it's very early. So, I feel like

151:31

we're going to have a conversation in 5

151:33

years time when there's more understood

151:36

about these compounds.

151:37

>> Well, the the thing that worries me is

151:39

that, you know, okay, you have the

151:41

person who's 300 lb and like they have

151:43

to get down like like that's really

151:45

unhealthy, right? It's that can really

151:47

be a gamecher for them. But now what

151:50

we're seeing is Hollywood. We're seeing

151:53

just just your average moms. They're

151:56

like, "I want to lose 10 pounds, but I

151:58

want it to be easy." Right? They're 10

152:00

or 15 pounds, whatever. And they're

152:02

going to these JLP1s.

152:04

And the question is, I don't know that

152:07

we have data showing it's actually

152:08

beneficial in that population because

152:10

they're already pretty pretty lean and

152:13

they're just wanting to look a little

152:15

bit better. And we don't really know. We

152:17

don't really know if it's beneficial. We

152:19

know that losing weight's beneficial for

152:20

sure and that's what these drugs are

152:22

doing. You're losing a lot of weight

152:24

rapidly. The other thing is gallstones.

152:26

Um you're getting the increased risk of

152:28

gallstones, right? Some people's

152:30

gallbladder has to be removed.

152:31

>> What about like anorexia and stuff like

152:33

that? Cuz I've got a couple of friends

152:34

who who are on the pen and they have

152:38

they have dropped weight at a speed that

152:41

has blown my mind. And part of me is

152:44

going stop like stop here. You know, I'm

152:46

thinking like I'm thinking, gosh, does

152:47

this just keep going down and down and

152:49

down and down and down?

152:51

>> I don't Yeah, I mean, I don't think it

152:53

keeps going down and down and down and

152:54

down generally. I think you kind of

152:56

stay. You hit a certain point and stay

152:58

>> if the dose remains the same.

152:59

>> If the dose remains the same. And I

153:01

think that people that are already kind

153:02

of like at a certain healthy weight

153:05

should taper down the dose too, right?

153:08

>> Um, and that's also been shown to help

153:09

at least with weight regain too. you

153:11

want to stop and get off it, you have a

153:14

better chance of success if you taper

153:16

down the dose and and don't just full

153:18

stop, you know, get off of it. Um, it

153:20

seems like tapering down helps people at

153:22

least slow the weight regain where it's

153:23

not happening all of a sudden. Your body

153:25

kind of adjust. But I also want to

153:27

mention, you know, there are other ways

153:30

that you can lose weight, right?

153:32

Intermittent fasting. Intermittent

153:34

fasting is so on the lowest dose of some

153:37

of these drugs like ozic for example if

153:40

you're on the lowest dose you can

153:41

achieve a similar amount of weight loss

153:43

from intermittent fasting as you do from

153:46

that and it's not you know if it's five

153:48

five you know 5 to 10% body weight not

153:51

huge amount but you know for people that

153:53

don't need to you lose a huge amount

153:55

that's a good way to do it because

153:57

you're going to get the metabolic switch

153:59

you're going to get the ketosis you're

154:00

not going to have to worry about the

154:01

side effects you don't have to worry

154:02

about regaining the weight because guess

154:04

what? You're going to adapt. Your body

154:05

adapts. You get used to the fasting

154:07

becomes easier. So, I think that, you

154:10

know, it it depends on the population

154:11

that we're talking about here. Do I have

154:13

concerns? Yes, I do. I have concerns.

154:16

But do I also think some of these people

154:18

that are obese and would never lose that

154:20

weight? Is are are they getting a

154:22

benefit from these drugs? Absolutely. I

154:24

think they are. But it all comes down to

154:26

the population who's using them. And

154:28

right now, it's become so popular in

154:31

everyone. And there's so many people I

154:33

don't think need to use it to lose their

154:34

10 pounds. It's ridiculous.

154:37

>> People take the path of least resistance

154:38

though, don't they? And appears to be

154:40

the path of least resistance for many.

154:41

So, we shall see, I guess. Rhonda, we

154:44

have a closing tradition where the last

154:45

guest leaves a question for the next,

154:46

not knowing who they're leaving it for.

154:48

And the question left for you, I think,

154:49

is a great one. It is, what is a

154:51

purchase that you made that is less than

154:54

$100 that improved your quality of life

154:58

the most?

154:59

That was probably okay. I have two.

155:04

Um, I would say the omega-3 index test

155:08

that is measuring your omega-3 fatty

155:11

acid levels.

155:12

>> And you can get that at home or

155:13

>> you can order it online and get it at

155:15

home. And you do a little you do like a

155:17

little spot of blood. It's like a finger

155:18

prick blood spot spot. And

155:22

just knowing that you're not in that you

155:25

want to be 8% range. 8% range is the

155:28

5year increased life expectancy. It's

155:30

the, you know, 66% lower dementia risk.

155:34

I mean, it's really where you want to be

155:35

to to be the healthiest. And you might

155:39

you might be supplementing with an

155:40

omega-3 supplement that's not really

155:42

working and you won't know it unless you

155:43

do take that test. And I think it's one

155:45

of the the easiest ones that I've done.

155:48

>> And how did that improve your quality of

155:49

life or are you saying it um

155:51

>> helped you avoid a bad quality of life?

155:53

It's no, I think it's improving my

155:54

quality of life because it's it's it's

155:56

slowing it's slowing my aging. That's

155:58

been shown with omega-3. It's absolutely

156:00

slowing aging. I told you omega-3 was

156:02

the only supplement that was able to do

156:03

that. Um, even in the context of people

156:06

that were healthy and physically active.

156:07

I mean, this the Swiss these Swiss

156:09

people are healthy. It's like if they

156:10

did the study in the US, there's no way

156:12

88% of them would be physically active.

156:14

Not a chance, right? Um, yeah. So, it's

156:17

it's slowing the aging process and that

156:19

is exactly what I want to do. It's going

156:20

to help with peak span. It's going to

156:22

help with, you know, health span. It's

156:23

going to help with life lifespan as

156:24

well. So, and it's it's affordable. It's

156:26

less than 100 bucks.

156:28

>> And the second one,

156:29

>> the second one I think um the one that

156:31

really did improve my in quality was a

156:34

continuous glucose monitor.

156:35

>> Oh, I thought you were going to say

156:36

creatine. Okay. Continuous glucose

156:38

monitor. No, no, no. You can't go back

156:39

now.

156:40

>> Yeah, it did. It did because I realized

156:44

how important sleep was for my metabolic

156:46

health. I thought I was doing everything

156:47

right for metabolic health and and it

156:50

was it was knowing how not getting

156:53

enough sleep was affecting my glucose. I

156:55

never would have thought that. Never

156:56

would have known. And most people that

156:57

get the continuous gluc glucose monitors

157:00

never think about that either. They

157:01

think about the food they're eating.

157:03

They don't think about sleep.

157:04

>> And when you get that continuous glucose

157:05

monitor, what is it you're looking at to

157:07

figure out the connection with sleep?

157:09

You can look at first you can look at

157:11

your fasting blood glucose levels and

157:12

you can go online and for your age and

157:14

and gender and figure out what's a

157:15

normal range.

157:16

>> So that's when you haven't eaten.

157:18

>> Yes. Okay. First thing in the morning

157:20

and you have not eaten. That would be

157:21

the easiest thing to look at.

157:23

>> Mhm. And the second thing

157:26

>> Yes. The second thing would be to look

157:27

at after you eat a meal 30 minutes to an

157:30

hour later making sure that you're

157:31

clearing that glucose from your meal.

157:33

And if you're not seeing that peak come

157:35

down and clearing there's something

157:36

wrong. Uh,

157:39

okay. I might wear another one of those.

157:40

It's been a while and they're quite

157:41

cheap. You can get them for like $20 on

157:43

on the internet. Dr. Ronda, I think

157:45

people are going to want to continue to

157:47

learn from you. So, where should they go

157:49

to learn more from you?

157:51

>> I have a podcast called Found My

157:53

Fitness. It's on YouTube, Spotify, Apple

157:55

Podcast, everywhere you listen to

157:56

podcasts. That would be the the best

157:59

place. I have a website,

158:00

foundmyfitness.com. I have a wonderful

158:02

newsletter. Every week we put out

158:03

something. We put out one on that

158:04

Peakspan paper. We put out a newsletter

158:06

on updating the exercise guidelines. I

158:09

have a great team. We put out an email

158:10

newsletter that's free every single

158:12

week. And they're really good. They're

158:14

really good in-depth emails so people

158:16

can find me there. I'm on social media.

158:18

Rhonda Patrick found my fitness. That's

158:20

all my that's my my handle, my website

158:23

name, my podcast name.

158:24

>> I'll link it below for anyone as well

158:26

that um would like to go check out that

158:28

information. It'll all be in the

158:29

description below. I highly recommend. I

158:31

mean, I don't really need to tell people

158:33

how incredible you are. I think they've

158:34

just observed that. So I shant. Um I

158:37

shall. You are incredible.

158:39

>> Thank you.

158:39

>> Um so thank you so much for doing this.

158:41

I've learned so much and I've done so

158:42

many of these health conversations on

158:44

this show and it's almost at a point now

158:46

where I'm wondering if there's much more

158:47

that I've got to learn. But because I

158:48

think you stay at the very cutting edge

158:50

of the studies that are coming out and

158:51

you're so good at both articulating them

158:54

in a simple way that someone like me can

158:55

understand even though I can't

158:57

understand a lot of the literature as it

158:59

comes out of these sort of scientific

159:00

journals. I think that you, you know,

159:02

you're a person people do need to follow

159:04

um because the world and the scientific

159:07

understandings are always changing and

159:09

it's good to have someone who can

159:10

distill that down for you in a way that

159:12

is relevant, accessible, and

159:15

scientifically rigorous. And that's

159:17

exactly sort of the three terms that I

159:18

think of when I think of you. So, please

159:20

do continue to do the work you're doing

159:21

because it's teaching me so much. And by

159:23

way of that, it's meaning that I can

159:24

live a happier, healthier life. And I

159:26

appreciate you for that, Ronda.

159:27

>> I really appreciate that. Thank you so

159:29

much, Stephen. I love coming and having

159:30

discussions with you. They're fun.

159:31

>> Thank you. YouTube have this new crazy

159:33

algorithm where they know exactly what

159:35

video you would like to watch next based

159:37

on AI and all of your viewing behavior.

159:40

And the algorithm says that this video

159:42

is the perfect video for you. It's

159:45

different for everybody looking right

159:46

now. Check this video out and I bet you

159:48

you might love

Interactive Summary

Dr. Rhonda Patrick discusses comprehensive health optimization, beginning with the pervasive impact of endocrine-disrupting chemicals found in everyday items. The conversation delves into the dangers of visceral fat, its causes, and effective strategies for its reduction, including specific dietary choices, sufficient sleep, and targeted exercise. She outlines the concept of "peak span" – maintaining 90% of peak bodily function – and provides recommendations for key supplements like fish oil, vitamin D, and creatine. The discussion also critically examines the limitations of current exercise guidelines, advocating for increased vigorous activity, and explores the potential long-term cognitive impacts of AI usage versus the benefits of active learning.

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