Cancer is very preventable. When the

medical establishment acknowledge what I

know about this disorder, what's causing

it, and what we're not doing to prevent

it or treat it, it will be recognized as

the greatest tragedy in the history of

medicine. Thomas Seyfried is a professor

of biology, genetics, and biochemistry

who has dedicated the past 30 years

gathering scientific evidence on what

could be the true origin and prevention

of cancer. Cancer is getting worse and

there's no major advance in reducing

death rates. And I can speak to the

reasons for that. All major cancer

research centers think cancer is a

genetic disease. You believe otherwise.

It's not whether you believe, it's what

the data tell us. And the evidence is

massive to support that cancer is a

metabolic disorder. And the problem is

we're doing everything we possibly can

in our lifestyle to induce it. The

scientific evidence is there. Like for

example, we know that cancer was

extremely rare in African tribes that

were living according to the traditional

ways. But when modern lifestyle entered

into their societies, cancer out of

control. We have been doing a study on

dogs. We know that wolves in the wild

don't die from cancer. But cancer is the

number one killer of domestic dogs. Why?

It's because of our lifestyle issues.

And a lot of us are doing things without

the knowledge that it would put us at

risk. But with metabolic therapy, you

can use it as both a prevention and a

treatment. And we're seeing more and

more of terminal cancer patients

outliving their predictability because

of this. And let me tell you one thing

and remember it. If you do metabolic

therapy, you can actually reduce risk

for cancer. You can take away the fear.

And when you say metabolic therapy, tell

me what those things are. Number one,

Before this episode starts, I have a

small favor to ask from you. 2 months

ago, 74% of people that watched this

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Thank you and enjoy this episode.

Professor Seyfried,

if someone walks up to you on the street

and they're, you know, they know nothing

about science, they know nothing about

medicine, etc., and they asked you,

"What do you do and why do you do it?"

How would you respond?

I'm a professor of biology at Boston

College. So, in that role, I spend a lot

of my time working with undergraduates

and graduate students in training them

to be scientific literate in in various

aspects of biology.

The research program that we have at the

university is also focused on

understanding how to manage cancer

better, how it originates, and how to

prevent it.

How much of a problem is cancer

globally? What are the sort of headline

statistics on the macro view of cancer

for someone that really doesn't know?

Yeah, well, it's getting worse. I can't

say there it's in the millions.

I I I know precisely what's going on in

this country because the American Cancer

Society

every year distributes the data on on

cancer. Um, we have almost 2 million new

cases diagnosed per year in the United

States.

And we have 1,700 people a day dying

from cancer in in the United States,

which comes to about 70 people per hour

in the United States. Now, when I went

to China,

I looked at some numbers there and it

was 8,000

people a day are dying from cancer.

Obviously, the population is so much

larger.

And I don't know what it is in the UK. I

mean, we'd have to go through their

cancer registries. But but what we do

know is that it's supposed to be a lot

worse by 2050 than it is today. So,

there seems to be no reduction in death

suffering

for this disease. And I I can speak to

the the reasons for that. But right now,

I would say it's a global epidemic of

cancer. It's not it's not getting

better, it's getting worse. More people

are dying from it. There's no major

advance in in reducing death rates. So,

it's a great tragedy. So, um, and when

we when we understand what's causing it

and what we're not doing to prevent it

or treat it, it'll it'll be recognized

as the singular greatest tragedy in the

history of of medicine worldwide when it

when when they come to know what I know

about this disorder and then they

realize what we've been doing

in in in a in a misdirected way, it will

be recognized as the greatest tragedy in

the history of medicine.

What types of cancer are people dying

from? What is the most popular types of

cancer for men and women? Well, it's

always been lung cancer pretty much for

men and women. Lung cancer is always

been the number one. But but we have

pancreatic, breast cancer, colon cancer.

These are all on the rise. Colon cancer

is on the rise. Pancreatic cancer is on

the rise in this country. I I I I can't

speak for other countries. They may

there vary slightly due to diet

lifestyle issues. But lung cancer has

always been recognized as as the number

one cancer. How many people in the

United States then, based on the

statistics, would develop cancer?

Well, it seems to increase every year.

So, it's kind of a moving target. It

doesn't seem to go down. You know, what

it is today, I don't know. But what I do

know is the numbers of people that are

dying each day because the

American Cancer Society comes out with,

I think it's 612,000

people

will die this year, 2024,

from cancer in this year. So, divide by

365 and it comes out to just about 1,700

people a day. Divide that number by 24

and you get about 70 people an hour

based on the numbers provided to us from

the American Cancer Society.

When they say we've made major advances

in in cancer incidences, right? So, in

the 1990s, they instituted the

anti-smoking campaigns. All right. So,

today, if you read, they say we have

reduced cancer deaths by 30 30 1 or 32%.

Wow, that sounds really impressive.

So, what they do is they take the

number. This is what the National The

American Cancer Society has done and has

published in their papers.

Okay, if we didn't stop smoking in the

'90s and everybody continued to smoke,

the trajectory would be very very high.

Because we stopped smoking or this

it's we have 33%

lower death than if we didn't stop

smoking. But the trajectory is

continuing to increase. Maybe not as

steep as it would have been had we

continued to smoke. So, it it was

clearly a prevention. It had nothing to

do with a a treatment. It had to do with

prevention. That was giving the the the

no oh, we've made major advances in in

reducing cancer death rate. Yeah,

because people stopped smoking. For the

for many many people,

more people would have died had they not

smoked. So, we have

um

people that are not not real people.

We're just looking at what would have

happened if if we didn't stop smoking.

What are the leading causes of death

worldwide in terms of diseases? Is Is I

I hear that heart disease is number one.

I think that's heart disease is number

one. Cancer is number two. Okay.

And there are many different types of

cancer, right? I heard there's hundreds

of different forms of cancer.

If you look under the electron

microscope or a correction, even the

light micro This is how most cancers are

diagnosed by by light microscopy.

You look under the microscope and you

see a bunch of cells that are dysmorphic

in the way they look and then they all

have genetic defects and all this kind

of stuff. But they all have one thing in

common. They depend on a on a

fermentation energy without oxygen. So,

all cancers are a singular type of

disease. It's just that they happen in

different tissues. But when you look at

the underlying problem, they're all very

very similar. They can't live without a

fermentation, which means energy without

oxygen. So, that's the common

pathophysiological problem in all

cancers, whether it's a colon, brain,

breast, bladder, skin, lung.

We we've looked at all these cancers and

they're all they're all essentially

using the same mechanism to to grow out

of control.

So, what is that fermentation you

mentioned?

Fermentation is energy without oxygen.

What does that mean?

We breathe air and we exhale CO2 and

water vapors. And those are the waste

products of the food that we eat. We

break Everything is broken down and

combusted in our mitochondria of the

cell. And the waste products are CO2 and

water vapors. Those are the waste

products. But if you and I were to stop

breathing for any particular time

period,

our bodies would fill up with lactic

acid and succinic acid. Like if we were

to have a heart attack or so when

somebody has a heart attack,

they don't die instantly.

If if they if they're there without for

5 or 7 minutes without oxygen, they they

may die because the brain dies. But if

you can get the heart to beat again and

get oxygen back in the system, you can

come alive again. But when we have that

massive interruption of oxygen into our

body,

the cells fall back on an ancient they

up they immediately turn on these

ancient pathways to get energy without

oxygen for a short period of time.

And that's the sugar glucose, which is

already in our bloodstream from the food

we eat, and the amino acid glutamine,

which is a

amino acid in our bloodstreams. Highest

level of amino acid is the glutamine.

These two fuels are now burned for

energy obtain energy without oxygen.

There's no There's a These pathways

upregulate and you can get ATP, which is

energy, to keep you alive for a short

period of time. But your bloodstream is

filling up with the waste products

called lactic acid and succinic acid.

Lactic acid is coming from glucose, the

sugar, and succinic acid is coming from

the amino acid glutamine. And they build

up and that tells you you're fermenting.

You're getting energy without oxygen cuz

you're not breathing. Very simple.

You're not breathing, but I'm not dead

yet. Now, of course, if you don't get it

for very long, you die. It's just that.

Now,

the other way you can stop oxygenation

in our bodies quickly is with the poison

cyanide. So, if we God forbid we were to

take cyanide, we'd be both dead within

within a minute. We just just

because our bodies are completely shut

down of energy from oxygen.

Now, here's the cancer cell.

The cancer cell

lives in in can live in in cyanide. The

cyanide does not kill a tumor, okay?

War- Otto Warburg showed this a long

time ago, and we've also shown the same

thing in our lab. Others have shown

this. The interesting thing is when you

look at cancer cells, even in the

presence of oxygen, even in oxygen,

they're throwing out lactic acid and

succinic acid. What does that mean?

That means the inner the organ organelle

inside the cell that generates energy is

not efficient. It's inefficient, and the

cells are using ancient fermentation.

And when I say ancient fermentation, you

have to realize the Earth is 4 and 1/2

billion years old.

Um

the organisms that existed on our planet

2 and 1/2 billion years ago were all

fermenters. There was no oxygen in the

atmosphere till the photosynthetic

bacteria started making oxygen. They

were living cells.

They had no oxygen, and they were

growing like crazy, unregulated growth.

Just unregu- What What's going on here?

And they would die as soon as the

fermentable fuels were dissipated. As

they gobbled up everything, they would

just die. So, they lived as long as they

could reproduce and have fermentation

fuels. The cancer cell in our body is

doing nothing than falling back on these

ancient fermentation pathways that

become accelerated up-regulated in the

tumor cell because the efficiency of the

energy coming from the mitochondria is

now

depleted. It's defective in many

different ways. So, this is very clear.

And this happens in lung cancer, colon

cancer. We've looked at all the major

cancers, and we found out these common

defects are seen in all cancers.

So, they're all very similar in their

metabolism. They're very different in

what they look like under the

microscope. Lung doesn't look like

colon, doesn't look like brain.

They're very different genetically.

They're all different from each other,

but they're all common in a in a

dependency on this ancient pathway of

energy metabolism. Can you take me back?

You mentioned a a guy called War-

Warburg there. Yeah. Can you take me

back on the journey that the scientific

community, or at least you, have been on

to arrive at the conclusion that the

central sort of causal factor, at least

an indication of a causal factor of

cancer, lies in this shift in energy

systems? Where did this understanding

start in in research? Well, it started

with Otto Warburg, for sure, in the

1920s.

The other linkage, before I tell you

what Otto Warburg did, because I was

like everybody else. I thought cancer

was a genetic disease, and and I heard

about Warburg, didn't really know what

what he was talking about or

but invested any time thinking about

what he said.

But Linda Nebling was an a PhD nursing

student at Case Western Reserve

University in in Ohio,

and she took these two little hopeless

kids brain cancer. We call hopeless

cases when they have no um

predictability of long-term survival.

And she gave them a ketogenic diet to

lower blood sugar, and she was able to

rescue these kids. One One One

eventually died. The other one was lost

to follow-up. And she said it her

strategy was based on what Otto Warburg

had said about glucose and cancer.

So, then I said, "Warburg?" I said, "Who

the hell What Let me go back and check

out who this guy was and what he did."

Because I was seeing similar things in

the in the mouse with that drug. It was

lowering glucose, and and we were

shrinking these tumor cells. And we

published a paper,

the first one of the first ever papers

linking that how high your blood sugar

is determines how fast your tumor will

grow in the mice. And now how this has

been replicated in all human cancers.

The higher your blood sugar, the faster

the tumor grows. The lower the blood

sugar, the slower the tumor grows.

Undeniable for all different human mouse

cancers. Wow. So, Warburg had said this

a long time ago, back in the 1920s.

He He was taking slices of all kinds of

human and rat and mouse tumors and

slicing them up, and he noticed

something really strange about these um

cancers. They take in less oxygen

compared to the normal tissue from which

they came. Wow, so they're kind of like

oxygen deprived, and they were throwing

out this lactic acid waste product that

he was that he was saying. And they were

taking in so much more glucose than the

normal. So, the normal cells take in

just a little bit of glucose, and they

can make tremendous energy from a tiny

amount. This guy was taking in huge

amounts of glucose, but not fully

metabolizing it to CO2 and water, but

dumping it out as lactic acid, which is

a a breakdown product of glucose that is

not fully metabolized in the cell. Wow,

he said, "This is unbelievable." And

then he did all kinds of tissue I looked

at his data. It was unbelievable. He was

cutting humans, mice, rats, and seeing

the same thing over and over again.

And he was saying the origin of cancer

has to do with something in the ability

of the mitochondrion, the organelle, to

generate efficient energy from oxygen.

So, the So, the mitochondria is the part

of the cell that creates energy. It's

the part of the cell that creates energy

through oxidative phosphorylation, which

is burning energy using oxygen, okay?

Okay, so it's like an engine. It's an

engine, a very highly efficient engine.

Now, this is an organelle You have to

realize we have the cell, Yeah. and we

have a nucleus that everybody knows

about, this nucleus. And then we have

all these little organelles in there. We

have lysosomes, and we have the

mitochondrion, which is like a spaghetti

network inside the cell. They fuse It's

actually a second living It's a second

living organism inside our cells. And to

simplify what they do, the mitochondria,

they convert oxygen and glucose into

energy. Yes, and they combust energy.

They They take The foods that we eat

have carbon-hydrogen bonds, okay? And we

break those down inside our

mitochondria. And we And we And we When

we break those bonds down, we create a

hydrogen gradient, and we dissipate that

gradient through an impeller mechanism

that generates energy like crazy. It's

unbelievable. Very efficient, highly

efficient. But the cancer cell has

corruption in that system. But it

doesn't happen overnight. As Warburg

said, "If you break that system too

acutely and too fast, the cell will die.

It doesn't have the So, you have to have

two things to get from oxidative

phosphorylation to energy with with with

minimal oxygen fermentation.

Sorry, just to keep it simple. From a

normal cell to a cancer cell.

From a normal cell to a cancer cell

doesn't happen overnight.

Okay. It's a chronic damage to the

ability of of that organelle

inside the cell to generate efficient

energy, okay? So, all we have to know

with cancer is that they're How are they

growing so rapidly? Why are they going

out of control? How come it's so hard to

kill them? Because as long as you have

those fermentable fuels that drive this

ancient fermentation pathway, um they

will continue to grow. They're very hard

to kill. And the fermenting fuels are

glucose and

And glutamine. Glutamine. Yeah. Okay.

So, here let's let me tell you in a

nutshell. I ready Brace yourself. Are

you ready?

I'm ready, I think so.

Are you braced? Are you braced?

Sufficiently braced.

Sufficiently He's sufficiently braced.

Okay.

So,

a solution to the cancer problem, to

manage cancer without toxicity, is to

simultaneously restrict the two fuels

that are needed to drive this

disregulated growth, while transitioning

the whole body off to a fuel that the

tumor cells can't use, which is fatty

acids and ketone bodies.

So, when we take the cancer patients or

the mice,

we put them into a calorie restriction,

lowering the blood sugar

that I said is one half of the two

fuels. You can lower that down really,

really low. And then we use specific

drugs to target the glutamine. And

together, we can selectively restrict

the two fuels while we transition the

whole body over to to ketones. We, as a

species, evolved to be in nutritional

ketosis for the the majority of our

existence as a as a species, like 1 and

1/2 million years. For for centuries and

centuries, thousands and thousands of

years, our species, you and me, our

ancestors, were always in a state of

nutritional ketosis because there was

very few carbohydrates in the

environment for them to be consuming,

right? So, the cancer cell, the body,

you and I could If we stopped eating and

we took a low-carbohydrate diet, just

did water-only fasting, we would get

into nutritional ketosis, where the

normal cells, our brain, our kidneys,

our heart can be burning these ketone

bodies because they have a good

mitochondria, and they can burn these

fuels effectively. The tumor cells have

a bad mitochondria. They can't burn

those fuels. They're dependent on

glucose and glutamine. We can replace

glucose and glutamine with ketone bodies

in the normal cells of our So, we

selectively marginalized these tumor

cells slowly over time. Uh we they

slowly start to die. The blood vessels

disappear, and the body comes in and

dissolves them. So, for someone that has

never heard the term keto before,

ketosis or ketones.

In a simple way, what are keto ketones?

Ketones are water-soluble breakdown

products of fatty acids, okay? They're

beta-hydroxybutyrate, acetoacetate.

These are small molecules that are

water-soluble. The liver throws them out

like crazy. Kidney a little bit, but

mostly liver. So, as I told you earlier,

when we don't eat, um

you you could get anxious, mainly

because our brains are addicted to

glucose. It's like cocaine and nicotine

and whatever.

You start getting all antsy. I haven't

eaten anything, you know. Uh what's

going on? Um so, you then once the body

realizes you ain't going to eat

anything, we have to start mobilizing

out of our fat resources. And the fats

uh go into the bloodstream as

triglycerides, which are

three fatty acids attached to a glycerol

backbone. They go to the liver.

The liver chops them up and puts out

these little water-soluble um ketone

bodies. That that the name ketone body

is kind of a weird thing from

biochemistry, but but they're called

ketone bodies. Um and they can supply

the brain with energy, the heart with

energy. And not only that, they're a

super fuel. It's unbelievable. The

mitochondria burns these ketones. Okay,

but they're energy Remember I was

talking about how energy efficient the

mitochondria become? When they burn

ketones, they become even more energy

efficient. It's unbelievable how you you

They don't need as much oxygen to

generate more energy. That's why they my

colleagues called and some of the greats

in the bio in the biochemistry field

called them super super fuel because you

can get more energy bang for buck

burning a ketone body than you can

burning a pyruvate coming from glucose

or even a fatty acid. Uh and the

biochemistry for that is is interesting.

But but the bottom line is when you

transition away from these fuels to keep

We don't forget we evolved. Our Our

ancestors were always in a state of

ketosis. You get into that state by

consuming very few carbohydrates and

having a lot of energy.

And this is the way our ancestors were.

So, what can we learn from our ancestors

about cancer? How prevalent was cancer

um

if when we look back at our ancestors if

they were often in a state of ketosis?

Yeah, well, um it's hard to determine

from skeletal records, uh but I think we

can look at um

modern popular modern man who live

according to their traditional ways. Um

you know, uh Albert Schweitzer, the

great humanitarian physician, went to

Africa and looked at Africans that were

living according to the traditional

ways. He said the one of the weirdest

things they don't have cancer. It was

like, "What? What?"

Uh the cancer was extremely rare in

Africans

in in the woods living in in the in the

areas uh British when they came, you

know, in in in looking at the health

conditions of folks that lived in the

Arctic Circle, cancer was not there.

They had other things, but they didn't

have cancer. Um aboriginal folks. So, it

seems as though uh our living We We

can't go back uh 50,000 years ago

because we don't have people to examine.

But we have people to examine today, and

that was one of the things Schweitzer

and several other uh physicians from

Europe would go to Africa, and they

would look at these some of these tribes

that were traditional, and they were

saying, "Whoa, what's going on with

these Africans? How come they don't have

cancer?" But when modern diet lifestyle

entered into their societies,

cancer out of control. What about What

about our other primate cousins? Yeah.

Um

there's never been a documented uh case

of breast cancer in a female chimpanzee.

Uh and they're 98% similar to us in gene

and protein sequence. Uh you know,

what's going on with that? Uh monkeys uh

they don't generally form cancer.

They're eating They're not eating what

we eat, okay? Don't forget we did not

evolve

to eat pork pies

and Dunkin' Donuts jelly filled donuts

and pizzas and We did not. Our ancestors

did not eat this, right? We were killing

and eating animals. I As I said, we ate

everything that walked, crawled, flew,

or swam on this planet became part of

our diet. Uh we did not have

donuts on every corner, delicatessens on

every corner. Our We evolved over this

period of time just like our primate

ancestors. Uh the animals chimps and

gorillas and things that you see in the

zoos are fed their natural diets as if

they were living in in their habitat,

their natural habitat, whether it was in

South America, Africa, or wherever it

was. Uh we're not throwing in jelly

donuts every day and pizza pie into the

chimpanzee pen. And as a matter of fact,

I even went to the zoo down down here in

in Boston, Franklin Park Zoo, and also

at the San Diego Zoo. I said, "How come

how come you guys don't give these guys

run down and get a big pizza for these

for these animals?" "Oh, no, it'd be

animal cruelty. Their systems aren't

geared for this." Well, neither are we.

We

We have an obesity epidemic. We have all

these different chronic diseases. Why?

We didn't evolve to eat all this crap

that we're eating today. So, what I've

told many people in these podcasts is

that our food science and technology and

our society's technology has evolved so

much faster than our biology.

Can you explain to me in simple terms

the role that exercise is playing in

staving off cancer?

Well, exercise lowers blood sugar, you

know, you and it also lowers glutamine.

So, uh the two fuels that are driving uh

Now, we can't completely remove

glutamine by exercise, that's for sure.

Um but we my late good friend George

Cahill published some papers on showing

how exercise could actually lower

uh glutamine availability. So, it's a

it's a little bit of a push. But you're

also

when you exercise, you're burning and

you're not eating a lot of carbs, your

mitochondria burning ketones and the

oxygenation from all the exercise is

keeping those mitochondria super healthy

at their highest level of energy

efficiency. So, exercise partic-

muscle as well, aren't you?

Yeah, you build Well, you can build

muscle, but you're certainly getting

aerobic exercise to

Oxygen is coming in and you're burning

ketones, which I already told you is a

super fuel. So, your body is super

healthy.

Uh These bodies from the Paleolithic

period, these men were jacked. There was

no obesity in these people. They had

tremendous energy. They're They're not

dying from uh the things that are

killing us. They're dying from injuries

and infections. When you described this

slow and gradual shift in the cell as it

moves to this sort of ancient system, it

sounded very gradual. So, in my head I

thought, "Okay, so does that mean that

the

cancer is a gradual process that is kind

of building up in me or isn't building

up in me based on the lifestyle

decisions I'm making and my

environmental factors

right now?"

It Look, I'm trying to say does Is Does

cancer start slowly

years before you you you know, you find

out you have cancer?

it it is a gradual process, but it can

be impacted by several provocative

agents from the from the

microenvironment. Um

lack of exercise. Okay. So, we're not

exercising nearly as much as our

Paleolithic ancestors, bar none, right?

We have massive amounts of processed

carbs in our diets. We have a lot of

emotional stress.

Mental emotional stress that's impacting

negatively uh on our biology.

Um we we have lack of sleep. Sleep uh a

lot of us because we we have stresses.

You You have to have When you put all of

these impactful things together in one

person, you can put yourself at risk for

cancer, all of which will damage and

reduce the efficiency of mitochondria.

And also uh the joy of living,

uh having friends and friendships and

and this kind of thing reduces stress in

a lot of different ways, makes people

enjoy getting up and and having a a nice

day rather than being depressed or or

these kinds of things. Um you put all

all this together and you put yourself

in a a diet and a lifestyle that puts

you at risk for damage to oxidative

phosphorylation and the transition from

one form of energy to a fermentation

energy.

What I'm trying to understand is that a

It's a gradual a gradual transition. You

have to be able to do that. And how long

does it take for a colon

a group of cells in a in a in a crypt of

your colon to transition from one stage

to another? You have to be constantly

under stress, those cells in that organ.

Now, why somebody gets colon cancer,

another person gets breast cancer,

another person gets bladder cancer, some

person gets a brain cancer, and all

these different kinds of cancers. What-

Whatever happened, the process was dis-

was causing a gradual disruption of

oxidative phosphorylation, oxidative

respiration,

and a and a gradual transition to a

fermentation. Like in the brain,

the neurons rarely if ever get cancer,

but the glial cells that support

neurons, they are usually the source of

the origin of cancer in the brain for

those kinds of cells. And you can look

at different cells, and some are more or

less prone. And why this guy get lung

cancer from from smoking cigarettes,

this guy got bladder cancer from smoking

cigarettes. How did it all start? It all

started from a population of cells in

one of those organs having an a chronic,

not instant, a chronic interruption of

oxidative energy followed by an

upregulation of this fermentation

energy. So, really we need to be

thinking about all the things that have

caused dysfunction in the mitochondria.

Absolutely. I want to get a list of the

key things that are associated with

causing this dysfunction.

Okay, carcinogens. Okay, so carcinogens.

Yeah, yeah, you know, there's many

asbestos, there's all kinds of chemicals

in the environment. You hear about this.

Oh, there's a whole list of carcinogens.

We

And they put them on the on the labels

on different chemicals. They say

carcinogenic potential and whatever, you

have.

What are the types of things that are

caustic carcinogenic that most people

don't realize? Oh, well, now we're

talking about microplastics. We're

talking about um Is that in part what

causes breast cancer? Cuz I always think

about deodorant with breast cancer and

and the stuff that we're kind of Oh,

yeah.

Yeah, well, the the one that was was

most interesting was the talcum powder

one. How does talcum powder would cause

ovarian cancer? Okay, it's taken up into

the urogenital tract, and it forms a

foci in in a part of the ovarian tissue.

What's a foci? Uh a a

like a collection of material, of foci

as a

an area where say talcum materials would

be accumulating.

Mhm.

And that leads to a inflammatory

um

area of the body. And our immune system

comes in to see what's going on. Our

immune system is a healing machine. And

they see something that's not not

normal. Normally they would clean it up.

But they throw a

cytokines and growth factors on there

leading to disregulate damage to

mitochondria and disregulate ascending

you get this tumor that starts. So if I

get a talcum powder

uh granule or whatever and it goes into

my body, my body then tries to attack it

to sort it out and in doing so it

creates inflammation which leads to

Damage to mitochondria in a particular

group of cells near that foci. Okay. And

this this is applicable to a I guess a

lot of different nano particles and

Yeah and microplastics and this now

they're looking at this. But then we

have chemical carcinogens.

Tetrahydrochloride, there's all kinds of

other things that can actually damage.

Arsenics and and these kinds of

chemicals um

urethane uh anything that could

chronically damage a mitochondrion

forcing over time forcing it to

upregulate the fermentation energy

without oxygen.

Isn't this most things?

I'm trying to figure out what I how to

live my life.

Yeah, well that's what that that's why

it was called the oncogenic paradox. But

but you can you can avoid that. That's

why I'm saying, if you can keep your

mitochondria healthy How?

Exercise and reduce

um

consumption of highly processed

carbohydrates.

Do I need to be avoiding these

microplastics as well? You you know, the

problem with microplastics they're very

ubiquitous. We're not really sure.

Uh we're just now becoming aware of it.

Nobody really knew that before. Um

look it up. It's But it could it could

cause um small foci in different

populations of cells. But you know, it's

very hard to really chronically damage

mitochondria. Mitochondria are tough

organelle. The problem is we are

chronically abuse it without realizing

what we need to do to keep it healthy.

So even if you are exposed to chemical

carcinogens, even if you are exposed to

all these things, but you're keeping

your body as healthy as you possibly can

you could possibly delay or even prevent

the damage to the mitochondria even

though you have the even though you are

being exposed to this. So it's a it's

actually in your hands.

Um

you can actually reduce risk

for cancer by knowing what keeps your

mitochondria healthy. Vigorous exercise,

uh fasting, water only fasting. Um you

know, it's very hard some but sometimes

we when we were putting mice on calorie

restriction, it was hard to get them to

have get tumors. Their body was so

healthy. This was shown years ago by by

a couple of scientists in mice using

mice with that developed a lot of breast

cancer. If you put them on a calorie

restricted diet, the incidence was way

way down. So you cancer is very

preventable. It's a very preventable uh

disorder. It's just that we're doing

everything we possibly can to

to induce it in our diet lifestyle. A

lot of big institutions believe that

cancer is a genetic problem.

Mhm. Um

You believe otherwise.

The evidence is striking. I mean, the

believe it's not whether you believe is

what the data tell us. Okay. So

according to the somatic mutation theory

of cancer, mutations in the nucleus lead

to disregulated cell growth.

That's the somatic mutation theory. In

the mitochondrial metabolic theory, it's

a transition from oxidative

phosphorylation to to a fermentation

metabolism inside inside the cell.

Um the mutations are largely irrelevant.

What do you mean by that? When the

mitochondria become defective, they

throw out ROS,

reactive oxygen species that are

carcinogenic and mutagenic. Well, what

does that mean? Causing mutations. So a

lot of the mutations that we see in the

nucleus of the tumor cell that is the

subject of the somatic mutation theory

are downstream effects of the

dysfunction of the mitochondria. So the

mitochondria is causing a downstream

effect which are mutations which are

according to the somatic mutation theory

are the cause of the disregulated cell

growth. Let me tell you why that's

absolutely untrue.

There's some cancer cells growing out of

control have no mutations and normally

not discussed. How can that be? That's a

a challenge to the theory. If the theory

says that all cancers have mutations and

you have some cancers that have no

mutations and they're growing out of

control that should say whoa, bell ring

one.

Uh then they the the somatic mutation uh

people, people who think this

said oh okay, we have a we have a

problem here. Not all mutations are the

ones that cause the disregulated only

some. And we have a name for those some.

That's called driver muta- Okay, now

that's a nice term. Because some of

those mutations are called passengers.

They don't really do anything. But the

drivers are the ones that lead to the

disregulated cell growth. So we should

be focusing our attention on these

driver mutations.

New evidence from the recent scientific

literature, can you believe this?

They're taking tissue, normal tissues

from patients, different organs and

things like this from not patients, from

normal people, no cancer, perfectly

healthy like yourself here.

We would take tissue from you and say,

"Oh my Christ, look at the you got

driver mutations in your esophagus and

your different parts of your body you

got driver. But you don't have a tumor.

What's going on with that? How do you

explain that these driver mutations are

causing disregulated cell growth when we

have thousands of driver mutations that

are there that are not causing

disregulated cell growth." Oh, okay,

that's a another problem.

The biggest devastating information

against the somatic mutation theory is

if you take the nucleus from a tumor

cell cleanly take it out of the tumor

cell and you have another normal cell

here you take the nor- the nucleus out

of the normal cell and you put the tumor

cell into that cytoplasm you get

regulated growth, no disregulated

growth. But if I have the normal cell

and have a tumor cell, take the tumor

nucleus out of there and take the normal

nucleus and put it into the tumor

cytoplasm which contains mitochon-

defective mitochon- disregulated cell

growth. This has been seen over and over

and over again. So just to summarize

that. So if you take the tumor nucleus

out of the cell and put it into a a

normal healthy cell

Yes. um everything's fine.

Everything is fine. But if you take

healthy cell nucleus and put it into a

tumor cell

Yeah. you still have the same

Disregulated cell growth.

tumor growth. So which means that it's

not the nucleus.

Absolutely. It's something else.

It's something else. And that's the

mitochondrion. And I told you then you

have cancer cells with no mutations.

And then you have driver mutations in

normal cells that never become cancer.

You put all those things together

and you have to be uh a hopeless

idealogue

to think that cancer is a genetic

disease.

Um it's a silent assumption in the field

that cancer is a genetic every textbook

of biology, cell biology and bioche-

cancer is a genetic disease. Why hasn't

people's opinions changed despite the

evidence that you present?

It's a very difficult thing.

It goes back to um

when you have one theory replacing

another theory, it's called paradigm

paradigm shifts.

And in all in history of science,

paradigm shifts have been met with great

great resistance.

Uh the clear- the clearest one was the

Copernican revolution

when uh for 8 1,800

years

astronomers in ours

uh

earlier astron- astronomers thought the

earth was immovable in the center of the

solar system. For 1,000 This was

Claudius Ptolemy,

Aristotle and the Bible and all these

Earth is immovable

and the sun and the moon and the planets

all revolve around the earth. 1,800

years.

Even Copernicus

uh was working with these mathematical

formulations. His cap was being

constantly confused until

he said, "What happens if we put the sun

in the center of the solar system and

consider the earth as simply another

planet that would revolve?" All all of a

sudden things started to make sense.

And Giordano Bruno,

uh a theologian, was put to death for

suggesting that Copernicus was right. Um

uh there was a tremendous resistance on

the part of the Roman Catholic Church at

that time.

And this is the same thing that happened

when when um Louis Pasteur said the

germs that germs rather than bad air are

the cause of disease.

So uh and when Darwin-Wallace theory of

evolution came it it's not special

creation, it's it's natural selection

that that can explain this. These were

massive paradigm changes in the history

of science. And what we're seeing today

is the same thing.

The mitochondria is the center of the

problem with cancer, not the nucleus.

The mitochondrion it's a mitochondrial

metabolic disease. And once you realize

that, we're going to drop these death

rates massively in a very

in a number of years for sure. So if we

take two paths then if we realize that

that the mitochondria is the center of

the dysfunction and ultimately disease

in the cell Yes. if we go that down that

path

what impact do you think that will have

on the cancer cancer statistics over the

coming years? It'll drop it massively.

Okay. I'm not going to say we'll get rid

of cancer completely. Uh but what here's

the thing. We may never get rid of it,

but we can learn to live with it and

keep it at bay. If we know how to if we

know that a cancer survive without these

two fuels and you can do a diet and

lifestyle that can restrict the

availability of those two fuels and keep

your mitochondria as healthy as you

possibly can. What if we don't go down

that path? What do you think? Then

you're going to be right. One out of two

people are going to be having cancer.

The your statistics are going to be uh

absolutely correct. Is there anybody

that

you believe cuz you know, when we talk

about these subjects, often we think of

like big farmer and the incentives and

money and follow the money and you'll

figure out why people don't want change.

Are is any of that sort of

conspiratorial thinking

correct in your view? Are there

know if that's conspiracy. I don't like

conspiracy terms. That's absurd.

I I like what are the facts

of what we're looking at. But do you see

a resistance from big farmer to

entertain this point of view. Um what Or

big food What what what what do you

think?

I mean would you think this is I mean

you're making a lot of not you but but

people in these in that those industries

the hospital industry is making enormous

amounts of money. They're rewarding we

get 7 billion dollars a year for cancer

research in the in the in in the

National Cancer Institute awarding many

many not all many grants to look at for

gene mutations and all this kind of

stuff.

Um and we have drugs that are extremely

expensive based on a somatic mutation

theory of cancer

that are basically not dropping the

death rate. As I said we got while we're

talking here you're going to have 140

people dead

uh from cancer.

Uh 1700 people a year it's getting worse

and worse. Um with as you said we're

always running for raising money for

cancer research. Uh where's all that

money going? What are you doing with all

that money? No accountability. And then

when you look at the scientific advisory

committee of all these societies that

you're running for they all think

publish papers on cancer as a genetic

disease.

It's too hard for the field to accept at

this point.

Um

It's it's too traumatic

at what I'm saying. It's too disruptive

to a massive industry

uh at this time. They will come to

gradually adapt adjust to what I'm

saying. It's just a matter of time

because we cannot continue this

trajectory.

It it's immoral what we're doing to some

of these people.

I read a stat that said the global

incidence of early onset cancer

increased by roughly 80% between 1990

Yeah. and 2019. That's in the BMJ

oncology.

Um early onset of cancer is basically

patients under the age of 50. And and

when I think about this you know growing

up in the UK whenever there's a a fun

run a charity race a marathon whatever

it might be

cancer research gets the money. Yeah.

And to hear that you know there's been

so much money invested in cancer

research over the last couple of decades

but there's been an increase of 80% in

early onset cancer in the same period.

For me I'm like

oh

this research doesn't appear to be do it

being very effective.

Well as I said you got to fight what

people don't do is they never ask where

is the research go what kind of research

what what are you doing? What is the

research? It's the theory that drives

the the impetus to do research. Now a

lot of great stuff has been done on

you know keeping people alive that

suffer from cancer is right? Because if

you think about the probability of dying

from a cancer

I'm I'm assuming that has gone down.

Yeah I to some extent it has. You know

we call this two ways of looking it's

called progression free survival and

overall survival.

Uh these are the terminologies that are

used in the clinical world of cancer. Uh

the and they they represent the approval

of drugs through the Food and Drug

Administration.

If you have a drug

that improves uh progression free

survival. Uh

progression free means it looks like the

drug is working on the tumor.

Um because you know the tumor you can

see it it gets bigger and bigger and

more lethal and more lethal. And and if

I see it not growing nearly as much

uh I say well look at the it's it's

slowing the what we call traditional

progression. Okay? It's called

progression free survival. And then you

have overall survival. So you have two

ways to approve drugs mostly for cancer

right? How does it work on progression

free survival and how does it work on

overall survival? Well they stopped

looking at overall survival. Now

somebody's going to bark and say well

you know bottom line is mostly

progression free. Which means that the

patients it looks like the tumor is

being effectively managed but they live

only a couple of months longer than they

would have if they didn't use this drug.

So therefore it's approved. And and and

um that as opposed to overall survival.

You know you're you're only living a two

Okay you've lived two and a half extra

months uh the tumor looked like it was

managed pretty well but your overall

survival is is this much but you you you

didn't see the tumor growing.

Uh we're going to approve that drug. So

a lot of the new drugs that we're giving

do a really good job at progression free

survival but they do a horrible job in

keeping people alive much longer which

ultimately is what you want to do. You

want overall survival.

Well let me give you an example. Avastin

uh bevacizumab. This this is an immoral

drug that should never be used on

people.

It was blocked because it caused colon

perforations in women with breast

cancer. They still use it on brain

cancer.

And when you so the in the tumor you got

a tumor you can see it with PET imaging

and you can not so much PET C

MRI and CAT scan you can see it there.

And I it's looking there. Okay.

Uh you can see it. Now you give the

patient Avastin and uh which is this um

anti-angiogenic drug. It's supposed to

stop the abnormal blood vessels right?

They think that the angiogenesis blood

vessels is is driving the disregulated

growth. It's the fermentation that's

driving the disregulated growth by the

way. So all of a sudden you give the

the tumor kind of disappears. It doesn't

look like it whoa patient gets all

excited. The physician looks and says

look at that look at that looks like

you're doing well.

What it does the event what the drug

does is it causes the tumors to

and permeate your entire your entire

brain. Just

like spreading it through your whole

brain. You don't live any longer

uh but you had this progression free.

Look at the tumor to the patient gets

excited because it looks like the tumor

is disappearing with this very expensive

drug. But what it does is it almost

guarantees that that patient will not

survive because you spread the tumor

cells through the whole brain.

So um this is why I call it an immoral

kind of a a thing.

But chemotherapy and sort of these

radiation therapies they have proven to

keep people alive who otherwise would

have died right?

In some cases

they it can and and that's another thing

we have to look at. We have

I I work heavily in brain tumors and

glioblastomas and things like that. When

you irradiate somebody's brain uh who

has one of these tumors you free up

massive amounts of glucose and glutamine

in the microenvironment. And if you look

at the survival and when we did the

survival looked at survival curves for

glioblastoma throughout the world oh

it's so you can't even design

experiments so consistent how fast

people will die. It's like all the

different hospitals have the same

survival same survival. What are you

doing? Well we do chemo we do surgical

debulking

uh temozolomide and we give steroids

which raise blood sugar and we irradiate

we irradiate we irradiate everybody's

dead. So um not everybody but you know

five year survival is is very very low.

10 year survival is almost zero.

Um But if you got if you got a breast

cancer or if you got

No this is brain cancer I'm talking

about. This is freeing up now. Yes if

you have a circumscribed tumor

and it's not anywhere else you can come

in with a radiation or surgical

procedure and cure essentially cure that

patient. But if you have any level of

spread or anything like this um that

that person now and

also if you're taking a toxic poison

into your body like red devil

doxorubicin they call it red devil. Your

pee turns red everything turns red.

What is that is that chemotherapy? Yes

it's a chemotherapy to kill a small

group of cells um or maybe a little bit

of a spread. But your

your hair falls out your body gets

brutalized um by this. And then if you

survive the cancer and many people do we

have millions and millions of cancer

survivors on this planet. But many many

folks in that group suffer from the

adverse effects of being poisoned or

irradiated or surgically mutilated. I

mean they have to change their whole and

often times the cancer comes back or

they die from cardiovascular disease or

they die from secondary adverse effects

of being brutalized um

with medieval I call it medieval

approaches to this. Are you kidding me?

What they're doing to cancer patients?

So when we do metabolic therapy

we we shrink the tumor down for sure.

Then the surgeon can come in and he sees

it smaller fewer blood vessels because

of the metabolic therapy and we can take

out a greater amount

of this and then we transition back to

prevent this tumor from recurring.

Metabolic therapy can you be used to not

only prevent the cancer but can also be

used to treat the cancer. Now let me

tell you they go most hospitals

suppose people say well you know I

really want to do things to prevent

cancer. Can I do standard of care before

I have a tumor? What do you mean? You

want to go into a a

major cancer clinic and have toxic

doxorubicin and radiation to your body

just in the event that you might get a

cancer? This is absurd. But yet when you

have cancer that's what they do to you

right? But with metabolic therapy you

can use it as both a prevention and a

treatment. It's just that with the

treatment we bring in some more drugs to

target the glutamine. We don't do that

on the prevention side. Only I was just

looking at some stats as you were

speaking around this five year survival

rates of a variety of different cancers

um over time and

it does appear that survival rates of

these cancers from breast cancer

prostate cancer to lung cancer to

leukemias um various melanomas has

improved since the 1970s.

So the 1970s to the 1990s to 2010s

there's been an improvement in the

survival rate. Um which I guess is a

credit to the research that's been done.

Um what you're saying is that this the

treatments we have still today are

horrific. Yeah and the and the survivals

are not that much greater. It's not like

you're getting massively longer

survivals. Yeah I mean and I have to I

have to preface that these stats might

not be right because this is AI we're

dealing with here but the there's a 5%

for example with breast cancer between

the 1990s and 2010 there's just a 5%

difference in overall survival.

in overall survival. Okay so your

survival is your overall survival is two

and a half to three months greater.

I don't actually have those stats in

front of me.

that's that's that's the the evidence

the papers that we're looking at.

So so how do we prevent

prevent this then?

I'm 32 years old now.

So I want to make sure that I live my

life in such a way that I limit my

chance of cancer. One of the things I

always reflect on is the fact that many

of the people that I know that have got

cancer breast cancer or other forms of

cancer appear to be remarkably healthy.

Yeah always at the beginning.

Uh they they're always but many times a

person comes in and she says, "I just

was diagnosed with cancer. I didn't know

I had it. I didn't feel bad." And then

all of a sudden you get treated and they

look like death warmed over. But I'm

saying like how can how can healthy

people be getting cancer if there's this

sort of central

Well, because you I as I said are the

the the the and we're seeing this. I'm

seeing it in my own I'm getting more and

more emails from young people in their

30s, uh, late 20s, 30s, early 40s like

with colon cancer, breast cancer and all

these kinds of things.

But look at our diet and lifestyle

situation today. Those those things that

I'm talking about, lack of exercise, a

lot of stress, poor sleep, bad food, all

of this kind of stuff impacting parts of

our bodies. So what do we do about it

then?

Know about it.

And then and then what do we do? So I

know now.

personal choice. I'm not here to take

pieces and and jelly donuts off the

market for sure or breakfast cereal. I

love that stuff too. But the the

question is I don't eat it every day and

I know if I do IT'LL KILL ME.

SO SO YEAH, I I SKIPPING MEALS, water

only occasionally. There's a lot of

things you can do to keep your

mitochondria healthy. Okay, so tell me

what those things are. I just exercise.

You look like you're a pretty healthy

guy.

Yeah, I go to I go to the gym a lot.

look morbidly obese to me. Not yet. Not

yet. Well, that's important because you

don't ever want it yet. We won't be in

America too long so my chances are

well and listen, it's not just the

United States. We were kind of like the

first ones to plow that field, but it's

starting to spread everywhere. I think

in China they have the most 200 million

obese people in China now. So should I

be on a keto diet then? Here's what we

did, okay.

Uh, we developed the glucose ketone

index calculator at Boston College, all

right, my students and I because we were

trying to

work with cancer patients blood sugar

and ketones, um, independently of each

other. We had a ketone meter and we had

a blood glucose meter. So we were

monitoring ketones by itself and glucose

by itself and we worked with a very nice

woman, um, from American who lived in

Nice, France who since passed away from

a brainstem tumor. It's very very

difficult. We kept her alive very long,

but

eventually we didn't know what we need

what we know now.

But she got into an argument for a

handicap parking spot with her neighbor

upstairs and her blood sugar blood sugar

went through the roof. She ran upstairs

and she took her blood blood sugar and

she says, "Oh my god, the tumor is going

to grow." I said, "What's your ketones?"

And she says, "Oh, it's still 2.5

millimolar."

Well, that's still pretty high. Usually

it's very very low. It's very high. So

my students and I we said, "You know,

this is too traumatic to try to measure

these two independently. Why don't we

make a singular number, divide the

glucose in millimolar in the blood by

the ketone in millimolar in the blood?"

Now you get this number that's much more

stable

and it allows the cancer patient to know

that if I keep this zone at 2.0 and

below, my tumor cells aren't going to be

able to grow very fast. I did this for

the brain cancer, right? Now it's being

used for all cancers and now it's being

used for guys like yourself who just

want to stay healthy and because what it

is essentially is a quantitative

determination of you're in the

Paleolithic zone or not.

Oh, so if I'm at 2.0 like my friend

Dominic D'Agostino, he's always down in

these zones. He's living the He's a

Paleolithic man living in modern

society. What's a Paleolithic man?

That's how our ancestors were during the

Paleolithic period. Okay, so he's got

the right balance of glucose and ketones

in his blood. Like we did when we were

hunting mammoths and and buffaloes and

these kinds of things. When we were

hunter-gatherers in the thousands of

years of our existence as a species,

tens of thousands of years. He is in

that zone. Is he in keto? He's Yeah,

well, that's the that's what the low GKI

is. That means you're at a level of

keto. Okay.

Yes, he doesn't eat a lot of

carbohydrates in his diet. He eats leafy

vegetables and a lot of meat and and

this kind of thing. Uh, sparingly on

fruits. Uh, like grapefruits we learned

from the epilepsy field, grapefruits

provide a tremendous amount of vitamin C

with don't and do not spike glucose.

That's that's very interesting. So you

can have, uh, certain fruits that can

keep you in this metabolic zone of pay I

call it the Paleolithic zone which is

the way we evolved where there was no

cancer in our in our existence. When

people hear that they might start

jumping on the paleo diet. I don't even

know what the paleo

diet. It's it's the diets that are low

in carbohydrates, okay? Okay. Um,

Mediterranean diets. Like people say to

me, "You talk like a what should I eat?

Should I eat this and that?" Normally

you would eat foods that have very low

low glycemic index which means the speed

with which glucose is released like a

banana, very high in glycemic index. You

eat a banana and your blood sugar

immediately spikes. Many fruits are like

that. Um, but you want you want foods

that keep a low steady, uh,

GKI. Now I built that, uh,

calculator for brain cancer patients

initially. Then we realized it's

powerful for all cancers. Uh, we put the

cancer patient in the low glucose ketone

index. We get them down in there. Then

we come in with the glutamine targeting

drugs to to kind of polish off these

tumors or put them in even a more

dormant state. But now I'm finding all

these young kid young like yourself, all

these 30 20-year-olds, what's the GKI? I

mean, they're out there weightlifting

and they're looking at their G They

don't have cancer. They're just excited

to see they they can get into this

Paleolithic zone by themselves.

And that yes, that will prevent cancer

because you can't get cancer if your

mitochondria healthy. If you if you're

in a Paleolithic zone where our

ancestors rarely if ever got cancer,

then you're you're back in this Oh, you

mean to tell me I can't eat this and I

can't eat that. What does it do to your

GKI? Oh, makes it go up. Well, don't eat

that.

So you did a study on dogs. A dog with a

tumor.

Yes. Can you tell me about that study?

Uh, it was a woman came to me

and this is what I say does you don't

have to have a

PhD in biochemistry

to understand what some of the things

this woman had no degree whatsoever. She

just heard the

uh, about what we did to these mice and

she did the same thing to her dog. Uh,

it was a pitbull and at 7 years old it

had big mast cell tumor on its lip.

So she listened to my YouTube video over

and over. She said to me, "I just kept

listening." And she says I I got I I I I

got some raw chicken.

She says dogs wolves evolved to eat

chickens. So she got some, uh, chicken

chopped up the chicken. She cut the

calories of she found some dog food

calculator to how much calories the dog

was getting. She cut the calories the

dog looks lost only 5% of its body

weight. She got, uh,

pollock fish oil, raw eggs and cut all

the calories to everything was all

natural for this dog. Um, and all of a

sudden we have the pictures. You can see

them in the pic if you saw the picture.

Big big tumor on its lip. The the the

veterinarian said this dog is going to

to survive you have to give him chemo

and radiation and surgery and all this

kind of stuff and it's going to cost a

lot of money. The dog's going to have

diarrhea. It's going to be, you know,

all She didn't want any part of that. So

she said, "Well, let's just try this

metabolic thing."

And we and she's kept all the records

and the pictures and what she did and

how much she gave the dog and all this

so I I was able to get all that

information from her.

Um, put my friend Lauren Lauren Nations

who is a veterinarian uh, on the paper

because I said, "What biology guy at

Boston College is telling you how to

manage cancer in a dog? We got to have

some veterinarian on here to validate to

make sure he's there." And he's looked

at the pictures and we looked at all the

thing. It disappeared. So what happened

was the dog eventually died of heart

disease at 15 and a half years of age.

So essentially that's the only

when people say

well, metabolic therapy cure cancer. I I

say metabolic therapy is never

considered a cure for cancer. It's an

effective non-toxic management for

cancer. But in the case of that dog it

appeared to work it appeared to cure the

dog, but that's the only one I'll say,

"Oh, he's going to say cure can not."

That dog happened to get he died from

old age from a heart heart attack. And

we did it with a brain tumor guy Pablo

Kelly who just passed away unfortunately

from a from a surgical, um,

his his, uh,

he had a

major cerebral, uh, hemorrhage after his

surgery from Devon, England. You know

Devon, England? That's where I'm from.

Are you from Devon? Yeah. Oh, wow. Well,

Pablo was there. He just passed away

unfortunately. I was talking to him the

day before he passed away. Pablo? Pablo

Kelly.

So he was from Devon, England. Had a

glioblastoma which is the worst of the

worst. Uh, they said and he was all over

your your newspapers there in Devon. He

was always sending me articles from

England. Um,

man rejects standard of care. So he he

had this glioblastoma and they took the

tissue out

Which is brain cancer. Yeah, brain the

worst of the brain cancers, you know.

Uh, they took the tumor out and they

said, uh, oh, you it's in inoperable,

inoperable. And, uh, but if you do

radiation and chemo, uh, we you might

live nine, maybe 12 months at the most.

Well, Pablo came from a family of like

we don't dabble in in this kind of

medicine. We're more holistic kind of

people. So he emailed me. This was in

2014. Um,

and said I want to try

this metabolic thing. So he rejected,

uh, chemo and radiation and they said it

wasn't surgically uh, capable of being

completely removed anyway.

So he did this I I gave him the

information that I give to everybody and

this was way back before we knew a lot

of what we now know.

And, uh,

I said this poor guy he he doesn't want

And they said, "You're going to be

dead." They they browbeat him. They

tried to

force him to put that radiation mask on.

They hacked his beard off,

uh, all this kind of stuff and he just

jumped up. He said, "I can't do this

stuff."

So, um, he didn't take any steroids. He

didn't take any any radiation. He didn't

take any chemo. He just did the

metabolic therapy and he's on English

tele

things with all of his paleo diet which

is actually a low very low carbohydrate

diet. He had the avocados there. He had

the fish oil there. He had this

different stuff.

And two or three years go by. He emails

me. I said, "Geez, Pablo, I thought you

would have been dead.

You're still alive? What's going on with

that?"

So so

he calls me up and he says, "You know,

um,

I went in for a CAT scan the other day.

The doctors are like still surprised

that he's alive and they said this tumor

is is still there and it's growing.

And they think they can cut it out now.

So, he was 3 years on on just metabolic

approach. He didn't take any glutamine

inhibitors, which was really remarkable.

So, and so anyway, he asked me and I

have I have physician friends that are

radiologists that can look at it and

they we measured it when it was first

first diagnosed in 2014 and then we saw

it did become a little bigger. So, and

then now that surgeon said, "I think I

can get it. Looks more more

susceptible." Here it was inoperable,

now it becomes resectable. So, he took

it out and Pablo recovered really well.

And the surgeon says, "I think I got it

all." Wow, so so and and Pablo is

measuring his glucose ketone index with

our ketone monitor. So, I had every day

sometimes two and three 5 years of data

on Pablo Kelly. Can you believe this?

So, so anyway, Pablo thinks he's cured

because the the surgeon all of a sudden

he goes back to his kind of weak weak

ways and you can see that his GKI goes

up and all of a sudden the tumor starts

to show up again. Puts the fear of God

back into him.

Goes back on a more restrict condition.

Another 3 years goes by and this time

the tumor is growing slowly very slowly.

Don't forget glioblastomas kill you very

quickly.

Um, with standard of care you can barely

get out of at his age if you can get 2

years you're doing you're doing really

good. So, anyway, now he's three and

he's got 6 years out and he says, "You

know, um,

it's still back, you know, I he said I

got to go in." So, he first So, this is

second debulking. First debulking he

goes off gets back on. Another second

debulking. So, another 3 years goes by

he has a third debulking. Can you

believe this? A third debulking?

Debulking is the cutting the tumor out.

It's the removal surgical removal of

this tumor. But he's never had radiation

or chemo or any other kinds of stand

what we call standards of care.

So, for and now, um, he he has I talked

to him a couple of weeks ago

and he was doing he was doing really

really good. He had the the third

removal and we were laughing

with myself and Dr. Durrant and my

associates.

He says, "Yeah, can you imagine um,

uh, I've had now three operations on a

previously inoperable tumor."

So, we were saying, "Wow, they got that

one wrong, didn't they, Pablo?" And they

kept wanting to irradiate him and do all

this stuff. He said, "No, no, I'm going

to keep doing this."

So, we were speaking to him

and and he's out 10 years.

The tumor was was diagnosed in in in

August 2014

and he passed away August,

uh, 2024

from they tried to go in and get the

last bit of tumor out of his brain. He

came out of it week on him. We talked to

him thumbs up smiling talking like crazy

6 hours later cerebral hemorrhage and he

dies.

So, he didn't die from the cancer. He

died from the surgical problem with the

surgery. So, he was a

You talk about long-term survivors. Um,

you rarely survive 2 years with a

glioblastoma. The fact that he was out

10 years and if he hadn't had that last

bit of surgery, the guy would have still

been alive cuz he he was talking like

you and I are talking. This is a guy who

has a a terminal So, I said to Pablo, I

said, "You could outlive me."

I I says I said, "We're all terminal to

some extent, right? We're never going

All of us aren't going to live to I says

you He was a young guy. He was only 20

22 or 23 when he was diagnosed. He was

in his 30s now when he passed away. 10

years, so he's 33 34 years old. And and

I said, "You know, I could be dead

before you." And we were laughing and we

had a good time and the next thing I

know I get an email from his wife. He

said Pablo was is on on on on

brain dead and something. I said, "What

the hell happened?

What happened to this poor guy?" And it

wasn't the cancer. So, who know how know

I don't know what how long he would have

lived how many more things. But what I'm

saying, "Oh, he's an anecdote." Well,

listen, if I had a drug that did what

what metabolic therapy did and I could

get more people like Pablo. You kidding

me? They'd be

run running all over the world. And when

you say metabolic therapy, you mean the

combination of the calorie restrictive

Yeah. ketogenic approach.

Yes. Yeah, we're avoiding Well, first of

all, you're avoiding you're avoiding

things that are going to kill you. The

radiation is going to kill you. For the

for many people, not all people. Okay,

everybody say, "Wait a minute." Well,

listen, you can you can look at the Go

have people look at the data themselves

for crying out loud. And you can see how

long you're going to live. He didn't do

what they what they grab everybody in.

What did he do specifically?

take radiation or chemo and he brought

his glucose ketone index down to the 2.0

zone and kept it kept it low. And he

took some supplements and a few things

here and there, but he wasn't really

targeting the glutamine like we thought

it would like we we thought We we found

now certain parasite medications will be

effective in targeting glutamine. So,

we're doing all non-toxic strategies to

manage cancer. You don't have to be

brutalized by the system if you know

what to do and how to do it. The problem

The problem is most of the poor

oncologist never heard of what I'm

talking. The stuff I'm telling you right

now, they never heard of it. The risk is

someone gets cancer that's listening to

this or someone has cancer that's that's

listening to this. I mean, statistically

there's a lot of people listening to

this that have cancer right now. And

they're they're speaking to their doctor

and their doctor is saying chemotherapy,

radiation therapy, etc. etc.

glucose has nothing to do with tumor.

Eat whatever you want.

Yeah, and so what do you say to those

people who are who they've just got a

diagnosis um,

and their doctors are saying, "Right,

listen, this is pretty bad severe. We're

going to suggest that you take

chemotherapy." You're not telling them

not to take chemotherapy, are you? I'm

not telling them that. And what we found

what we found is that when you are in

nutritional ketosis with a glucose

ketone index of 2.0 or below

my colleagues that we work with in

Istanbul, Turkey were able to show that

chemotherapies at much lower dosages can

be even more therapeutically powerful

when you're in nutritional ketosis. So,

you don't have to get rid of a lot of

these different procedures that we have

today. I'm just saying radiation for

brain cancer. I'm not saying radiation

for lung or some of the other cancers.

Okay. Because if you can if you can

shrink those tumors down and make them

very weak and vulnerable a surgical

procedure or radiation procedure even

low-dose chemo could come in and even

immunotherapy. If you if you took a big

tumor and shrunk it down to a small

small nub and it's resistant to a lot of

the things. They all have to share

something in common for them to survive

this this path. That might be an

immunotherapy because come in because

they're going to target whatever all of

them have together and you could

possibly get rid of it that way.

I'm thinking of a friend of mine that

has been diagnosed with brain cancer

brain tumor.

And this is one of the most you know,

it's a it's a woman in her 40s or 50s

trying to keep her anonymous as

possible. Um, who is just the most fit

athletic person I ever I know. Eats

amazingly well. Is literally known for

exercise.

Um, and I'd go, "How? How is it possible

that someone who I would probably say is

fitter than I am if you looked at their

sort of metabolic health has got a

severe brain tumor?"