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Essentials: The Neuroscience of Speech, Language & Music | Dr. Erich Jarvis

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Essentials: The Neuroscience of Speech, Language & Music | Dr. Erich Jarvis

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891 segments

0:00

Welcome to Huberman Lab Essentials,

0:02

where we revisit past episodes for the

0:04

most potent and actionable science-based

0:06

tools for mental health, physical

0:08

health, and performance.

0:11

I'm Andrew Huberman, and I'm a professor

0:13

of neurobiology and opthalmology at

0:16

Stamford School of Medicine. And now for

0:18

my discussion with Dr. Eric Jarvis.

0:21

Eric, so great to have you here.

0:22

>> Thank you. Yeah, very interested in

0:24

learning from you about speech and

0:27

language in terms of the study of speech

0:29

and language and thinking about how the

0:31

brain organizes speech and language. Uh

0:34

what are the similarities? What are the

0:36

differences? How should we think about

0:38

speech and language?

0:38

>> There really isn't such a sharp

0:41

distinction. Now let me tell you how

0:43

some people think of it now that there's

0:46

a separate language module in the brain

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that has all the algorithms and

0:50

computations that influence the speech

0:52

pathway on how to produce sound and the

0:56

auditory pathway on how to perceive and

0:58

interpret it uh for speech or for you

1:01

know sound that we call speech. I don't

1:04

think there is any good evidence for a

1:05

separate language module. Instead,

1:09

there is a speech production pathway

1:12

that's controlling our larynx,

1:13

controlling our jaw muscles that has

1:16

built within it all the complex

1:18

algorithms for spoken language. And

1:21

there's the auditory pathway that has

1:24

built within it all the complex

1:25

algorithms for understanding speech, not

1:28

separate from a language module. And

1:30

this speech production pathway is

1:32

specialized to humans and parrots and

1:36

songirds. Whereas this auditory

1:38

perception pathway is more ubiquitous

1:41

amongst the animal kingdom. And this is

1:43

why dogs can understand sit ce

1:48

boy get the ball and so forth. Dogs can

1:50

understand several hundred human speech

1:52

words. Great apes you can teach them for

1:55

several thousand but they can't say a

1:57

word. What do we understand about modes

2:00

of communication that are like language

2:03

but might not be what would classically

2:05

be called language?

2:07

>> Right? So next to the brain regions that

2:09

are controlling spoken language are the

2:11

brain regions for gesturing with the

2:13

hands. And that hand parallel pathway

2:17

has also complex algorithms that we can

2:19

utilize. And some species are more

2:21

advanced in these circuits, whether it's

2:24

sound or gesturing with hands, and some

2:26

are less advanced. Humans are the most

2:29

advanced at spoken language, but not

2:32

necessarily as big a difference at

2:34

gestural language compared to some other

2:37

species. So, as you and I are talking

2:39

here today, and people who are listening

2:41

but can't see us, we're actually

2:43

gesturing with our hands as we talk uh

2:47

without knowing it. We're doing it

2:49

unconsciously and if we were talking on

2:51

a telephone, I would have one hand here

2:53

and I would be gesturing with the other

2:55

hand without even you seeing me, right?

2:58

And so why is that? Some have argued and

3:00

I would agree with based upon what we've

3:02

seen is that there is an evolutionary

3:05

relationship between the brain pathways

3:07

that control speech production and

3:09

gesturing. Uh and and the brain regions

3:12

I mentioned are directly adjacent to

3:14

each other. And why is that? I think

3:16

that the brain pathways that control

3:17

speech evolved out of the brain pathways

3:20

that control body movement. All right?

3:23

And um that uh when you talk about

3:28

Italian, French, English, and so forth,

3:31

um each one of those languages come with

3:33

a learned set of gestures

3:36

that you can communicate with. Now, how

3:38

is that related to other animals? Well,

3:41

Koko, a gorilla who is raised with

3:42

humans for 39 years or more, uh, learned

3:46

how to do gesture communication, learned

3:49

how to sign language, so to speak,

3:52

right? But Koko couldn't produce those

3:54

sounds. Koko could understand them as

3:57

well

3:58

by s by seeing somebody sign or hearing

4:01

somebody produce speech, but Koko

4:04

couldn't produce it with her voice. And

4:06

so what's going on there is that a

4:10

number of species, not all of them, a

4:11

number of species have motor pathways in

4:13

the brain where you can do learn

4:15

gesturing, rudimentary language if you

4:18

wanted, say, with your lens, even if

4:20

it's not as advanced as humans, but they

4:22

don't have this extra brain pathway for

4:24

the sound. So they can't gesture with

4:27

their voice in the way that they gesture

4:29

with their hands. One thing that I've

4:31

wondered about for a very long time is

4:33

whether or not um primitive emotions

4:38

and primitive sounds are the early

4:41

substrate of language. When I smell

4:43

something delicious, I typically inhale

4:47

more and I might say or something like

4:51

that. Whereas if I smell something

4:52

putrid, I typically turn away. I wse and

4:55

I will exhale trying to not ingest those

4:58

molecules or inhale those molecules. I

5:01

could imagine that these are the basic

5:04

dark and light contrasts of the language

5:06

system. This kind of primitive to more

5:09

sophisticated

5:10

um pyramid of of sound to language. Is

5:14

this a crazy idea? Do we have any uh do

5:17

we have any evidence this is the way it

5:18

works?

5:19

>> No, it's not a crazy idea. And in fact,

5:21

you hit upon one of the key distinctions

5:24

in the field of research that I started

5:26

out in, which is vocal learning

5:28

research. Most vertebrate species

5:30

vocalize, but most of them are producing

5:33

innate sounds that they're born with. Uh

5:35

that is babies crying, for example, or

5:38

dogs barking. And only a few species

5:41

have learned vocal communication, the

5:43

ability to imitate sounds. And that is

5:46

what makes spoken language special. When

5:48

people think of what's special about

5:50

language, it's the learned

5:52

vocalizations. That is what's rare. So

5:55

all the things you talked about, the

5:56

breathing, the grunting and so forth, a

5:58

lot of that is handled by the brain stem

6:01

circuits, you know, right around the

6:03

level of your neck and below uh like a

6:06

reflex kind of thing. So or or even some

6:09

emotional aspects of your behavior in

6:11

the hypothalamus and so forth. But for a

6:14

learned behavior, learning how to speak,

6:17

uh, learning how to play the piano,

6:19

teaching a dog to learn how to do tricks

6:22

is using the forebrain circuits. And

6:25

what has happened is that there's a lot

6:27

of forebrain circuits that are

6:28

controlling learning how to move body

6:30

parts in these species, but not for the

6:31

vocalizations. But in humans and in

6:34

parrots and some other species somehow

6:37

we acquired circuits where the forebrain

6:40

has taken over the brain stem and now

6:43

using that brain stem not only to

6:45

produce the innate behaviors or vocal

6:47

behaviors but the learned ones as well.

6:49

>> Do we have any sense of when modern or

6:53

sophisticated language evolved

6:56

>> amongst the primates which we humans

6:57

belong to? we are the only ones that

7:00

have this advanced vocal learning

7:01

ability. Uh now when you it was assumed

7:06

that it was only homo sapiens. Uh then

7:10

you can go back in time now based upon

7:12

genomic data not only of us living

7:15

humans but of the fossils that have been

7:17

found for homo sapiens of Neanderthalss

7:20

of Dennisovven uh individuals and

7:23

discover that our ancestor our human

7:27

ancestors

7:28

supposedly hybridize with these other

7:31

homminid species.

7:33

And it was assumed that these other

7:35

homminid species don't learn how to

7:37

imitate sounds.

7:39

I don't know of any species today that's

7:41

a vocal learner that can have children

7:44

with a non-vocal learning species. I I

7:46

don't see it. It doesn't mean it didn't

7:48

exist. uh and when we look at the

7:50

genetic data from these ancestral

7:53

homminids that uh you know where we can

7:56

look at genes that are involved in learn

7:59

vocal communication they have the same

8:01

sequence as we humans do for genes that

8:04

function in speech circuits. So I think

8:07

Neanderthalss had spoken language. I'm

8:09

not going to say it's as advanced as

8:11

what it is in humans. I don't know. Um

8:13

but I think it's been there for at least

8:15

between 500,000 to a million years.

8:17

Maybe we could talk a little bit more

8:19

about the overlap between brain circuits

8:21

that control language and speech in

8:24

humans and other animals. You know, I

8:26

was weaned in the neuroscience era where

8:28

bird song and the uh the ability of

8:32

birds to learn their tutor song was and

8:34

still is a prominent field um sub field

8:37

of neuroscience. And this notion of a

8:39

critical period, a time in which

8:40

language is learned more easily than it

8:43

is later in life. And the names of the

8:46

different brain areas were quite

8:48

different. Um it one opens the textbooks

8:50

we hear vernicks and brocas for the

8:52

humans and you look at the bird stuff. I

8:54

remember you know

8:56

>> HBC a robust arch striatum area X right

8:59

that's right. Uh how similar or

9:01

different are the brains brain areas

9:03

controlling speech and language in say a

9:05

song bird and a and a young ch human

9:08

child.

9:08

>> Yeah. So going back to the 1950s or and

9:12

even a little earlier and Peter Mer and

9:14

others who got involved in

9:16

neuroethology, the study of neurobiology

9:19

of behavior in a natural way, right? Um

9:22

you know they start to find that

9:25

behaviorally there are these species of

9:27

birds like song birds and parrots and

9:29

now we also know hummingbirds just three

9:30

of them out of the 40some bird groups

9:33

out there on the planet orders that they

9:35

can imitate sounds like we do. And so

9:38

that was the similarity. In other words,

9:40

they had this kind of behavior that's

9:42

more similar to us than chimpanzees have

9:44

with us or than chickens have with them,

9:46

right? They're closer relatives. And

9:49

then they discovered even more

9:50

similarities, these critical periods

9:52

that if you remove a child and you know

9:56

this unfortunately happens where a child

9:57

is feral and is not raised with human

10:00

and goes through their puberty phase of

10:02

growth, becomes hard for them to learn a

10:05

language as an adult. So there's this

10:07

critical period where you learn best and

10:09

even later on when you're in regular

10:11

society it's hard to learn. Well the

10:13

birds undergo the same thing and then it

10:16

was discovered that if they become deaf

10:19

we humans become deaf our speech starts

10:22

to deteriorate without any kind of

10:23

therapy. Uh if a non-human primate or um

10:28

you know or let's say a chicken becomes

10:31

deaf uh their vocalizations don't

10:33

deteriorate very little at least. uh

10:36

well this happens in the vocal learning

10:37

birds. So there were all these

10:39

behavioral parallels that came along

10:41

with a package and then people looked

10:43

into the brain Fernando Nataba my former

10:46

PhD adviser and began to discover the

10:48

area X you talked about uh the robust

10:51

nucleus of the archopelium

10:53

and um and these brain pathways were not

10:57

found in the species who couldn't

10:58

imitate. So there was a parallel here

11:00

and then uh jumping many years later you

11:03

know I started to dig down into these uh

11:06

brain circuits to discover that these

11:08

brain circuits have parallel functions

11:10

with the brain circuits for humans even

11:12

though they're by a different name like

11:14

brocas and linja motor cortex. And most

11:17

recently we discovered not only the

11:19

actual circuitry and the connectivity

11:21

are similar but the underlying genes

11:23

that are expressed in these brain

11:25

regions in a specialized way different

11:27

from the rest of the brain are also

11:29

similar between humans and song birds

11:31

and parrots. So all the way down to the

11:33

genes and now we're finding the specific

11:35

mutations are also similar. Not always

11:38

identical but similar uh which indicates

11:41

remarkable convergence for a so-called

11:43

complex behavior in species separated by

11:46

300 million years from a common

11:47

ancestor. And not only that, we are

11:50

discovering that mutations in these

11:53

genes that cause speech deficits in

11:56

humans like in fox P2, uh if you put

11:59

those same mutations or similar type of

12:01

deficits in these vocal learning birds,

12:03

you get similar deficits. So convergence

12:06

of the behavior is associated with

12:08

similar genetic disorders of the

12:10

behavior.

12:11

>> Do hummingbirds sing or do they hum?

12:14

Hummingbirds hum with their wings and

12:16

sing with their searings

12:17

>> in a coordinated way.

12:19

>> In a coordinated way. There's some

12:21

species of hummingbirds um that actually

12:24

will um Doug Ashler showed this that

12:27

will flap uh their wings and create a

12:30

slapping sound with their wings that's

12:33

in unison with their song and and you

12:36

would not know it, but it sounds like a

12:38

particular syllable in their songs. uh

12:41

even though it's their wings and their

12:43

voice at the same time.

12:45

>> Hummingbirds are clapping to their song.

12:47

>> Clapping with their they're snapping

12:49

their wings together uh in unison with a

12:52

song to to make it like if I'm going da

12:54

da da da da da, you know, and I banged

12:57

on the table except they make it almost

13:00

sound like their voice with their wings.

13:02

What's amazing about hummingbirds and I

13:04

we're going to say vocal learning

13:05

species in general is that for whatever

13:08

reason they seem to evolve multiple

13:11

complex traits. You know this idea that

13:14

evolving language, spoken language in

13:16

particular comes along with a set of

13:19

specializations. When I was coming up in

13:22

neuroscience, I learned that I think it

13:25

was the work of Peter Marlor that um

13:28

young birds learn song birds learn their

13:31

tutor song and learn it quite quite

13:34

well. But that they could learn the song

13:37

of another tutor. In other words, they

13:39

could learn a different, and for the

13:40

listeners, I'm doing air quotes here, a

13:42

different language, a different bird

13:44

song, different than their own species

13:46

song, but never as well as they could

13:48

learn their own natural genetically

13:52

linked song.

13:53

>> Yes,

13:54

>> genetically linked meaning that it would

13:56

be like me being raised in a different

13:57

culture and um that I would learn that

14:01

the other language, but not as well as I

14:03

would have learned English. This this is

14:05

the idea. Is that true?

14:07

>> That is true. Yes. And that's and that's

14:09

what I learned growing up as well and

14:10

and and talked to Peter Mer himself

14:12

about before he passed. Um he had this

14:15

he used to call it the innate

14:17

predisposition to learn. All right. So

14:20

um which would be kind of the equivalent

14:23

in the linguistic community of universal

14:25

grammar. There is something genetically

14:29

influencing our vocal communication on

14:32

top of what we learn culturally. And so

14:35

there's this ba balance between the

14:37

genetic control of speech or a song in

14:39

these birds and the learned uh cultural

14:42

control. And so so yes, if you were to

14:46

take um you know um I mean in this case

14:49

we we actually tried this at

14:51

Rockerfeller later on. Take a zebra

14:53

fininch and raise it with a canary. It

14:56

would sing a song that was sort of like

14:58

a hybrid in between. We call it a

14:59

caninch, right?

15:02

uh and vice versa for the canary because

15:04

there's something different about their

15:06

vocal musculature or the gen or the

15:08

circuitry in the brain. And with a zebra

15:10

finch, even with a closely related

15:12

species, if you would take a zebra finch

15:15

uh young animal and in one cage next to

15:18

it place its own species, adult male,

15:21

right? And in the other cage place a

15:23

Bengal finch next to it, it would

15:25

preferably learn the song from its own

15:28

species neighbor. But if you remove its

15:30

neighbor, it would learn that bangal

15:33

finch very well.

15:34

>> Fantastic.

15:34

>> So there's it it has something to do

15:36

with also the social bonding with your

15:38

own species. That raises a question that

15:41

I based on something I also heard but I

15:43

don't have any uh scientific

15:45

peer-reviewed publication to point to

15:47

which is this this idea of pigeon not

15:49

the bird but this idea of when multiple

15:52

cultures and languages converge in a

15:54

given geographic area that the children

15:56

of all the different native languages

15:58

will come up with their own language. I

16:01

think this was in island culture maybe

16:03

in Hawaii called pigeon which is sort of

16:05

a hybrid of the various languages that

16:07

their parents speak at home

16:09

>> and that they themselves speak and that

16:11

somehow pigeon again not the bird but a

16:15

language called pigeon for reasons I

16:16

don't know

16:18

harbors certain basic elements of all

16:21

language

16:22

>> is that true is that not true

16:25

>> what is going on here is cultural

16:28

evolution remarkably tracks genetic

16:31

evolution. So if you bring people from

16:34

two separate populations together that

16:36

have been in their separate populations

16:38

evolutionarily at least for hundreds of

16:41

generations. So someone speaking

16:43

Chinese, someone speaking English. Uh

16:45

and that child uh then's learning from

16:48

both of them. Yes. That child's going to

16:50

be able to pick up and merge uh uh uh

16:54

phonms and words together in a way that

16:58

an adult wouldn't because why? they're

17:01

experiencing both languages at the same

17:03

time during their critical period uh

17:06

years in a way that um adults would not

17:09

be able to experience. And so you get a

17:11

hybrid and the lowest common denominator

17:14

is going to be what they share. And so

17:16

the phonms that they've retained in each

17:19

of their uh languages is what's going to

17:22

be I imagine used the most. So we've got

17:26

brain circuits in songirds and in humans

17:29

that in many ways are similar perhaps

17:31

not in their exact wiring but in their

17:34

basic contour of wiring and genes that

17:36

are expressed in both sets of neural

17:38

circuits in very distinct species that

17:41

are responsible for these phenomenon

17:43

we're calling speech and language. I

17:44

mean what are what are these genes

17:45

doing? Uh, one of the things that differ

17:47

in the speech pathways of us and these

17:49

song pathways of birds is some of the

17:51

connections are fundamentally different

17:53

than the surrounding circuits. Like a um

17:56

a direct cortical connection uh from the

17:59

areas that control vocalizations in the

18:00

cortex to the motor neurons that control

18:02

the larynx in uh humans or the serrings

18:05

in birds. And so we actually made a

18:07

prediction uh that since some of these

18:09

connections differ, we're going to find

18:11

genes that that control neuro

18:13

connectivity uh and that specialize in

18:15

that function that differ. And that's

18:17

exactly what we found. Uh um genes that

18:20

control what we call axon guidance and

18:22

form in connections. And what was

18:24

interesting, it was sort of in the

18:26

opposite direction that we expected.

18:29

That is some of these genes, actually a

18:32

number of them that control neuro

18:33

connectivity were turned off. in the

18:36

speech circuit. All right? Uh and it

18:39

didn't make sense to us at first until

18:40

we started to realize the function of

18:42

these genes are to repel connections

18:44

from forming. So repulsive molecules and

18:47

so when you turn them off, they allow

18:50

certain connections to form that

18:51

normally would have not formed. So it's

18:53

a so by turning it off, you got a gain

18:55

of function for speech, right? Um uh

18:58

other genes that surprised us were genes

19:01

involved in calcium buffering neurop

19:03

protection like a parvamine or heat

19:07

shock proteins. So when your brain gets

19:08

hot these proteins turn on and we

19:11

couldn't figure out for a long time why

19:12

is that the case and then the idea

19:15

popped to me one day and said ah when I

19:17

heard the larynx is the fastest firing

19:20

muscles in the body. All right. In order

19:23

to vibrate sound and and modulate sound

19:26

in the way we do, you have to control,

19:29

you have to move those muscles, you

19:31

know, three to four to five times faster

19:34

than just regular walking or running.

19:36

And so, um, when you stick electrodes in

19:40

in the brain areas that control learn

19:42

vocalizations in these birds and I think

19:43

in humans as well, uh, those neurons are

19:46

firing at a higher rate to control these

19:48

muscles. And so what is that going to

19:51

do? You're going to have lots of

19:53

toxicity in those neurons unless you

19:55

upregulate molecules that take out uh

19:58

the extra load that is needed to control

20:01

the larynx. And then finally a third set

20:03

of genes that are specialized in these

20:05

speed circuit are involved in

20:07

neuroplasticity.

20:08

Uh neuroplasticity meaning allowing the

20:11

brain circuits to be more flexible uh so

20:15

you can learn better. And why is that? I

20:18

think learning how to produce speech is

20:20

a more complex learning ability than say

20:24

learning how to walk or or learning how

20:27

to do tricks and jumps and so forth that

20:29

dogs do

20:30

>> in terms of plasticity of speech and the

20:33

ability to learn multiple languages but

20:35

even just one language. What's going on

20:37

in the so-called critical period? And

20:39

then the second question is if one can

20:40

already speak more than one language as

20:44

a consequence of childhood learning is

20:46

it easier to acquire new languages later

20:48

on.

20:49

>> Actually the entire brain uh is

20:51

undergoing a critical period development

20:54

not just the speech pathways and uh so

20:57

it's easier to learn how to play a

20:58

piano. It's easier to learn how to ride

21:01

a bike for the first time and so forth

21:03

as a young child than it is later in

21:06

life. The brain can only hold so much

21:08

information. And if you are undergoing

21:11

rapid learning to learn to acquire new

21:14

knowledge, you also have to put memory

21:16

or information in the trash like in a

21:18

computer. You you only have so many

21:20

gigabases of memory. Plus also for

21:23

survival, you don't want to keep

21:25

forgetting things. And so so the brain

21:28

is designed I believe to undergo this

21:31

critical period and solidify the

21:34

circuits with what you learned as a

21:36

child and you use that for the rest of

21:37

your life. And now the question you

21:40

asked about if you learn more languages

21:43

as a child, can you is it easier to

21:45

learn as an adult? And that's a common

21:47

uh finding out there in the literature.

21:49

There are some that argue against it,

21:50

but for those that support it, the idea

21:52

there is um you you are born with a set

21:56

of innate sounds you can produce of

21:58

phonms and you narrow that down because

22:00

not all languages use all of them. And

22:03

so you narrow down the ones you use to

22:05

string the phonms together in words that

22:07

you learn and you maintain those phonms

22:10

as an adult. And here comes along

22:13

another language that's using those

22:15

phonms or in in different combinations

22:16

you're not used to. uh and therefore

22:19

it's like starting from first principles

22:22

but if you already have them in multiple

22:24

languages that you're using then it

22:26

makes it easier to use them in another

22:28

third or fourth language. So it's not

22:30

like your brain has under has maintained

22:32

greater plasticity is your your brain

22:35

has maintained greater ability to

22:37

produce different sounds that then

22:39

allows you to learn another language

22:41

faster. What about modes of speech and

22:43

language that seem to have a depth of

22:45

emotionality and meaning but for which

22:48

it departs from structured language? I

22:51

think of musicians like there are some

22:53

Bob Dylan songs that to me uh I

22:55

understand the individual words. I like

22:59

to think there's an emotion associated

23:00

with it. At least I experienced some

23:02

sort of emotion and I have a guess about

23:04

what he was experiencing. But if I were

23:07

to just read it linearly without the

23:09

music and without him singing it or

23:12

somebody singing it like him, it

23:14

wouldn't hold any meaning. So in other

23:15

words, words that seem to have meaning

23:18

but not associated with language but

23:21

somehow tap into an emotionality.

23:23

>> Absolutely. So, so we call this

23:26

difference um semantic communication,

23:29

communication with meaning and effective

23:32

communication, communication that has

23:34

more of an emotional feeling content to

23:37

it. I believe you know based upon

23:39

imaging work and work we see in birds

23:42

when when birds are communicating

23:45

semantic information in their sounds

23:46

which is not too often but it happens

23:49

versus uh effective communication sing

23:52

because I'm trying to attract the mate

23:54

my courtship song or defend my territory

23:56

it's the same brain circuits it's the

23:58

same speech like or song circuits are

24:00

being used in different ways there

24:03

there's several other points here I

24:04

think it's important for for the those

24:06

listening out there to here is that when

24:08

I say also this effective and um

24:12

semantic communication um being used by

24:15

similar brain circuits it also matters

24:16

the side of the brain uh in birds and in

24:20

humans um there's there's left right

24:23

dominance uh for learn communication

24:26

learned sound communication uh so the

24:29

left in us humans is more dominant for

24:31

speech but the right has a more balance

24:35

for singing or processing musical sounds

24:38

as opposed to processing speech. Both

24:40

get used for both reasons. And so when

24:43

people say your right brain is your

24:45

artistic brain and your left brain is

24:47

your thinking brain, this is what

24:49

they're referring to. Uh and uh so

24:52

that's another distinction. The second

24:54

uh thing that's useful to know is that

24:57

all vocal learning species use their

24:59

learn sounds for this emotional

25:02

effective kind of communication, but

25:05

only a few of them like humans and some

25:08

parrots and dolphins use it for the

25:10

semantic kind of communication we

25:12

calling speech. And and that has led a

25:16

number of people to hypothesize that the

25:19

evolution of spoken language of speech

25:21

evolved first for singing uh for this

25:25

more like emotional kind of made

25:27

attraction like the Jennifer Lopez the

25:30

Ricky Martin kind of songs and so forth.

25:32

Uh and then later on it became used for

25:35

abstract communication like we're doing

25:37

now.

25:38

>> I'd love to chat a moment about facial

25:40

expression many of which are

25:42

subconscious. We are all familiar with

25:44

the fact that when what somebody says

25:47

doesn't match some specific feature of

25:49

their facial expression that it can um

25:52

call you know that mismatch can cue our

25:55

attention.

25:56

>> Yeah.

25:56

>> So how does motor circuitry that

25:58

controls facial expression map on to the

26:01

mo the brain circuits that control

26:03

language, speech and even bodily and

26:05

hand movement?

26:05

>> Yeah. You ask a great question because

26:07

we both know some colleagues like

26:09

Winrich Frywald at Rockefeller

26:11

University who study facial expression

26:13

and the neurobiology behind it.

26:15

Non-human primates have a lot of

26:17

diversity in their facial expression

26:19

like we humans do. And what we know

26:21

about the neurobiology

26:23

of brain regions controlling those

26:25

muscles of the face is that these

26:27

non-human primates and some other

26:29

species that don't learn how to imitate

26:30

vocalizations, they have

26:34

strong connections from the cortical

26:36

regions to the motor neurons that

26:38

control facial expressions. And even

26:40

though it's more diverse in these

26:41

non-human primates, there was already a

26:43

pre-existing diversity of communication,

26:47

whether it's intentional or unconscious,

26:49

through facial expression in our

26:51

ancestors. And on top of that, we humans

26:55

now add the voice uh along with those

26:58

facial expressions. So it's like an

27:00

email, too. You're you're emailing and

27:02

someone says something by email. someone

27:04

can interpret that angrily or or gently

27:08

uh and it it be becomes ambiguous. The

27:11

facial expressions get rid of that

27:12

ambiguity.

27:13

>> I'm so glad you brought that out because

27:15

my next question was and is about

27:17

written language. What is the process of

27:20

going from a thought to language to

27:23

written word and what's going on there?

27:26

What do we know about the neural

27:27

circuitry? What I think is going on is

27:30

to explain what you're asking is about

27:33

that I'm going to take it from the

27:34

perspective of reading something. You

27:36

read something on a paper. The signal

27:38

from the paper goes through your eyes.

27:40

It goes to the back of your brain to

27:42

your visual cortical regions eventually.

27:45

That visual signal then goes to your

27:47

speech pathway in the motor cortex in

27:49

front here in Brocas area. And you

27:52

silently speak what you read in your

27:55

brain without moving your muscles. And

27:57

sometimes actually if you put electrodes

28:00

EMG electrodes on your lendial muscles

28:02

even on birds you can do this you'll see

28:05

activity there while reading or or or

28:08

trying to speak silently even though no

28:10

sound's coming out. And so your speech

28:15

pathway is now speaking what you're

28:18

reading.

28:19

Now to finish it off that signal is sent

28:22

to your auditory pathway so you can hear

28:24

what you're speaking in your own head.

28:26

That's incredible.

28:27

>> And this is why it's complicated. Oh,

28:29

and then you got to write, right? Okay,

28:32

here comes the fourth one. Now, the hand

28:34

areas next to your speech pathway is got

28:37

to take that auditory signal or even the

28:39

adjacent motor signals for speaking and

28:41

translate it into a visual signal on

28:43

paper. So, so you're using at least four

28:46

brain circuits um which includes the

28:49

speech production and the speech

28:51

perception pathways to write. Stutter is

28:54

a um particularly interesting case. What

28:58

is the current neurobiological

28:59

understanding of stutter and are what's

29:03

being developed in terms of treatments

29:04

for stutter?

29:05

>> Yeah. So we actually uh accidentally

29:08

came across stuttering in songirds and

29:11

we've published several papers on this

29:13

to try to figure out the neurobiological

29:15

basis. The first study we had was a

29:17

brain area called the basil ganglia or

29:20

the what's the the strium part of the

29:22

basil ganglia involved in coordinating

29:25

movements learning how to make movements

29:27

when it was damaged in these in this in

29:30

the speech-like pathway in these birds.

29:32

What we found is that they started to

29:34

stutter as the brain region recovered

29:39

and unlike humans they actually

29:42

recovered after three or four months.

29:44

And why is that the case? Because bird

29:46

brains under goes new neurogenesis in a

29:49

way that human or mammal brains don't.

29:52

Uh and it was the new neurons that were

29:55

coming in into the circuit uh but not

29:58

quite you know with the right proper

30:00

activity uh was resulting in this

30:02

stuttering in these birds. uh and after

30:06

it was repaired not exactly the old song

30:08

came back as a after the repair but

30:10

still it recovered a lot better and it's

30:14

now known they call this neurogen

30:16

neurogenics

30:17

stuttering in humans uh with damage to

30:20

the braz ganglia or some type of

30:22

disruption to the basil ganglia at a

30:24

young age also causes stuttering in

30:27

humans and even those who are born with

30:29

stuttering uh um it it's often the basil

30:33

ganglia uh that's disrupted than some

30:36

other brain circuit and we think the

30:38

speech part of the basil ganglia.

30:40

>> Can adults who maintain a stutter from

30:42

childhood uh repair that stutter?

30:44

>> There are ways to overcome the

30:47

stuttering through um through uh you

30:50

know behavioral therapy. Uh and I think

30:53

all of the uh tools out there have

30:57

something to do with sensory motor

30:59

integration. Uh controlling what you

31:01

hear with what you output in a a

31:05

thoughtful controlled way helps reduce

31:08

the stuttering.

31:09

>> Texting is a very very interesting

31:13

evolution of language. I wonder

31:16

sometimes whether or not we are getting

31:18

less proficient at speech because we are

31:21

not required to write and think in

31:25

complete sentences.

31:26

>> Mhm.

31:27

>> What do you think is happening to

31:28

language? Are we getting better at

31:30

speaking, worse at speaking? And what do

31:32

you think the role of things like

31:34

texting and tweeting and shorthand

31:36

communication, hashtagging,

31:39

what's that doing to the way that our

31:40

brains work? Uh texting

31:43

actually has allowed for more rapid

31:46

communication amongst people. It's more

31:48

like a use it or lose it kind of a um

31:52

thing with the brain. The more you use a

31:55

particular brain region or circuit, the

31:57

more enhanced it's like a muscle. Uh the

32:00

more you exercise it, the more healthier

32:02

it is, the bigger it becomes and the

32:04

more space it takes and the more you

32:05

lose something else. So I think texting

32:09

is not decreasing the speech prowess or

32:13

the intellectual prowess of speech. It's

32:15

converting it and using it a lot in a

32:18

different way in a way that may not be

32:20

as rich in in regular writing because uh

32:24

you you can only communicate so much

32:27

nuance in short term writing. But um

32:30

whatever that whatever is being done,

32:33

you got people texting hours and hours

32:35

and hours on the phone. So whatever your

32:38

thumb circuit is going to get pretty big

32:40

actually

32:42

for those listening who are interested

32:44

in getting better at speaking and

32:46

understanding languages. Are there any

32:50

tools that you recommend? Should kids

32:51

learn how to read hard books and simple

32:54

books? Uh what do you recommend? Should

32:56

adults learn how to do that? Everyone

32:57

wants to know how to keep their brain

32:59

working better, so to speak, but also I

33:01

think people want to be able to speak

33:03

well and people want to be able to

33:05

understand well.

33:06

>> Yeah. What I've discovered personally,

33:08

right, is that so when I switched from

33:11

uh pursuing a career in science from a

33:15

career in dance, I thought one day I

33:17

would stop dancing. Um but I haven't

33:19

because it I find it fulfilling for me.

33:22

And there have been periods of time like

33:24

during the pandemic where I slowed down

33:26

on dancing and so forth. Um and and when

33:29

you do that you realize okay there there

33:31

parts of your body where your muscle

33:32

tone decreases a little bit and somewhat

33:34

and or you could start to gain weight or

33:37

I somehow don't gain weight that easily

33:38

and I think it's related to my dance if

33:40

that's that that's meaningful to your

33:42

audience. But what I found is in science

33:45

we like to think of a separation between

33:47

movement and action and cognition. And

33:50

there is a separation for you between

33:51

perception and production. Cognition

33:54

being perception, production being

33:56

movement, right? But if the speech

33:59

pathways is next to the movement

34:00

pathways, what I discover is by dancing,

34:04

it is helping me think. It is helping

34:07

keeping my brain fresh. It's not just

34:09

moving my muscles. I'm moving or using

34:13

the the circuitry in my brain to do

34:15

control a whole big body. You need a lot

34:19

of brain tissue to do that. And so I

34:21

argue if you want to stay cognitively

34:25

intact into your old age, you better be

34:27

moving and you better be doing it

34:29

consistently, whether it's dancing,

34:31

walking, running, and also practicing

34:34

speech, oratory speech and so forth, or

34:38

singing is controlling the brain

34:40

circuits that are moving your facial

34:41

musculature. And it's going to keep your

34:43

cognitive circuits also in tune. And I'm

34:46

I'm convinced of that from my own

34:48

personal experience.

34:49

>> This has been an incredible conversation

34:51

and opportunity for me to learn. I know

34:54

I speak for a tremendous number of

34:55

people. And I I just really want to say

34:57

thank you for joining us today. You are

34:59

incredibly busy. It's clear from your

35:01

description of your science and your

35:03

knowledge base that you are involved in

35:05

a huge number of things. Um very busy.

35:08

So, thank you for taking the time to

35:09

speak to all of us. Thank you for the

35:11

work that you're doing. Thank you for

35:13

inviting me here to get the word out to

35:15

the community uh of what's going on in

35:18

the science world.

35:19

>> Well, we're honored and very grateful to

35:20

you, Eric. Thank you. You're welcome.

Interactive Summary

In this insightful discussion, Dr. Andrew Huberman and Dr. Eric Jarvis explore the neurobiology of speech and language, challenging the idea of a single 'language module' in the brain. They detail how speech production and perception pathways in humans share remarkable evolutionary parallels with songbirds, particularly in their use of specialized forebrain circuits and shared gene expression. The conversation further covers the impact of critical periods on language acquisition, the connection between motor movement (including dance) and cognitive maintenance, and the fascinating way our brains translate thought into spoken or written language.

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