This may be the most controversial thing

we have on this table. This is a peptide

that absolutely torches belly fat at a

disproportionate rate. And what we found

is not only do patients lose an

incredible amount of weight, but they

also get the best improvements we've

ever seen in their liver health. It's

absolutely wild. And I think this is

going to be a trillion dollar drug when

it comes out. And I brought you here

because you're an expert on this subject

matter. And it's worth saying that there

was some significant news about this.

>> Correct. from the FDA saying that in

July they are going to consider

legalizing seven peptides and by

pharma's estimate it might be the most

dangerous thing to their entire business

model.

>> So do you think it is plausible that big

farmer didn't want these in the hands of

regular people because they can't patent

this and it's powerful

>> 110%. Because the question isn't what

can peptides do, it's what can't they do

and we've got several peptides here in

front of us and I want to go through all

of them.

>> Let's do it. So, this is probably the

most well-known peptide for skin

complexion and it improves quality of

hair and nails. And then epialon is

maybe maybe not going to be the fountain

of youth, but I'm very skeptical as far

as that goes. Next, we've got this. And

if you injected that at night, it would

improve your quality of your sleep.

Next, melan too. And this will actually

end up giving you a deep tan in response

to just a little bit of UV sun exposure.

It'll also give you some of the most

impressive erections you've ever had in

your life. So, be warned. And what else

have we got? Oh my gosh. There's

methyline blue where people take it and

they think it's going to make them live

forever. Don't take this. It literally

will stain your nails blue and your hair

blue. These two here stimulates building

muscle. This one can aid with healing

after an injury. And then is this this?

This this. It's crazy. It's wild.

>> So why don't I take it?

>> Well, we need to talk about that because

there are trade-offs.

>> But also outside of the world of

peptides for a second. I've got these

three vials. Do you know what those are?

>> Yeah. This is unfortunately our future

if we're not careful.

>> Explain. So, what we've got here is

representing the fertility trajectory

for young men. And I'm so scared.

This is super interesting to me. My team

given me this report to show me how many

of you that watch this show subscribe.

And some of you have told us according

to this that you are unsubscribed from

the channel randomly. So, favor to ask

all of you, please could you check right

now if you've hit the subscribe button

if you are a regular viewer of the show

and you like what we do here. We're

approaching quite a significant landmark

on this show in terms of a subscriber

number. So, if there was one simple free

thing that you could do to help us, my

team, everyone here, to keep this show

free, to keep it improving year over

year and week over week, it is just to

hit that subscribe button and to double

check if you've hit it. Only thing I'll

ever ask of you. Do we have a deal? If

you do it, I'll tell you what I'll do.

I'll make sure every single week, every

single month, we fight harder and harder

and harder and harder to bring you the

guests and conversations that you want

to hear. I've stayed true to that

promise since the very beginning of the

D of Sio, and I will not let you down.

Please help us. Really appreciate it.

Let's get on with the show.

Dr. Alex Tatum.

There's this word that has exploded in

society in recent times. In fact, when I

look at the data, people searching this

word has increased by 400%

just recently. And that word is

peptides.

I have no idea what peptides are. I'm

someone that wants to be healthy, that

wants to optimize my health, wants to

live long, doesn't doesn't love aging.

>> Yeah.

>> And I'm told that this word peptides is

somewhat linked to it. So, I've brought

you here because you're an expert on

this subject matter. I've watched your

videos on YouTube. To start at the very

beginning, Dr. Alex.

>> Sure. What the hell is a peptide?

Peptides are a structural class of

medications. The best way to think about

peptides is that just like we have small

molecules which are drugs that are very

small taken in a pill and have a wide

ranging effect throughout the body.

Peptides are derived from little pieces

of amino acids which think of them as

the Legos that make up the human body.

The Legos that make up proteins. These

are fragments of proteins that are

designed to specifically target certain

receptors and affect cells in a very

targeted fashion. Or a best way to think

about it is a very specific targeted key

to unlock a very specific lock. So

instead of a small molecule that may

have a wide ranging effect throughout

the body, peptides are much much more

focused.

>> So you've got different types of Lego

cubes here. Would they be different

types of peptides or are they different

types of amino acids that come together

to make a peptide?

>> The best way to think about it is my son

loves Legos, which is why I'm glad that

we have these here. But he can take the

same set of Legos and he can build a

rocket ship and then just a few minutes

later he can build a pirate ship and

then he builds a race car. And he's

using the same Legos, but he's creating

very, very different things that all do

very, very different things. And so

peptides have become incredibly popular

because yes, we have some really

fascinating peptides that can help with

anti-aging, with healing, and with

tissue repair. We're going to talk about

some of those hopefully, but they can do

so much more than that. The first

peptide that was actually isolated and

used in medicine, was insulin back in

1921.

And then all the way in 1985 in the

world of urology which is where I was

trained we had luplide which is a

different peptide that again also had

peptide like insulin but instead of

having wide-ranging metabolic effects it

had an endocrine effect. It was designed

to shut down the production of

testosterone for prostate cancer

patients that needed to have their

testosterone taken away.

>> Interesting. Okay. So insulin is a

peptide.

>> Insulin is a peptide

>> because it's a series of amino acids

>> amino acids that are put together.

>> Okay. So you said that the combination

of amino acids forms a key.

>> So what is the lock?

>> The lock could be a cellular receptor.

It could actually be regulating a

certain pathway within the cell.

>> Okay. So let me repeat this back to you

to make sure I understand it. So

peptides are like a key.

>> Yes.

>> Which you can make by configuring amino

acids in a certain way. And there's

different locks in our body that these

keys can go into. So if I take, you

know, we got some peptides on the table

in front of us here. So, a a good way to

think about it is this. If you've got a

hammer, right, which is what a lot of

small molecules are, like you can do a

lot with that, right? Like you could a

hammer in a nail, but if you try to use

that hammer when you're trying to put in

a screw or you're trying to put

together, you know, a table that you got

from IKEA, it may not always end the way

that you want to. And that's the problem

that we have with a lot of small

molecules. It's not that they don't do

what we want them to. They do a lot of

other things while they're at that job

that can have significant negative side

effects, which is why a lot of these

small molecules actually don't make it

all the way through the FDA approval

process because we find something, it

does what we want to do, but has

significant safety concerns down the

line. All right. Now, what we see with

peptides, for example, I've got in my

hand right now a little vial labeled,

you know, BPC57.

This is probably one of the most popular

peptides that we're talking about right

now because BPC-157 is a synthetic

version of a naturally found peptide in

the gut. But what this actually does is

it enhances blood vessel growth in areas

of injury. And it kind of makes sense

because if you think about it, our gut,

our stomach is really just this bag of

acid that sits inside of our abdomen.

And yet somehow you and I are here

talking to each other and our bodies

aren't eating themselves. Well, how does

that work? Well, it's because we've

developed a lot of really robust systems

to encourage healing of the gastric

lining. And so the idea is like, well,

if this is one of the compounds that can

help do that, it's been proven in

multiple animal models. For example,

they have completely transsected the

Achilles tendon in rats and then

>> transected

>> transected. So they've cut across the

Achilles tendon. So, not just a small

injury that you or I might experience in

the gym where we pull it or strain it,

but actually surgically cut the uh

Achilles tendon and then they administer

it to rats and they are healing

spontaneously with administration of

BPC7.

If you have an Achilles tendon injury

and you're a rat, BPC7 is one of the

best things that you can ever have. Now

that is not a onetoone translation to

what we might see in humans. But as we

talked about earlier with our point on

safety when they were studying BPC57

we try to look for something called the

LD1 or the LD50. How much can I give

this to someone until 50% of the

population that receives that dose

doesn't do well or dies. Okay, that's

called the LD50 dose. We have yet to

figure out what the LD1 dose is for

this, which is the amount that it would

take to hurt even 1% of the population

because it is so incredibly well

tolerated. So, just giving you an

example of this is a compound that can

have profound healing effects at least

in our animal models that we've seen so

far, but so far we haven't seen any

precipitous negative effects in human

patients when taking this. Okay. But we

need more data. I am mind blown and I'm

very very excited. We've got all of the

se several peptides here in front of us.

I want to go through all of that and

understand which ones do which things.

But there's a bigger question here which

is why now why have the subject of

peptides suddenly exploded into

society's consciousness? What's going

on? What's the big picture?

>> So this is really interesting. In 2013

there was actually a court case in the

United States. It was the it was called

Myriad Genetics case. This was the

company that actually patented the BRAA

1 and BA 2 genes. They discovered the

genes that cause breast cancer. All

right, this was mind-blowing. They

identified the specific genes that would

predispose patients to developing both

breast, ovarian, and since we've learned

also prostate cancer. It was a fantastic

discovery, but they patented it and they

said, "We now own this intellectual

property." And then everyone else said,

"No, no, no. That's that's the human

body. You can't patent that." And the

Supreme Court actually sided with that

argument saying that if something is

natural, it's found within us. Okay, I

can't patent you know your muscle cells,

right? Which is a wonderful thing. But

the unintention unintentional byproduct

of that is all of a sudden pharma had no

incentive whatsoever to pursue really

promising compounds that they could not

monetize. So that happens in 2013. At

the same time, I believe it was around

2012 2013, there was a terrible event

that happened in New England where there

was a compounding pharmacy that was not

doing the right thing and they ended up

having a bunch of contaminated specimens

that caused a fungal menitis. Bunch of

patients got really sick. It was a huge

scandal and all of a sudden the FDA

stepped in and said, "Hey, historically,

all right, states have been allowed to

regulate compoundingies themselves, but

we need some federal oversight here

because this is not acceptable."

Completely agree with that. And they

introduced a new set of regulations on

top of compoundingies, basically saying

what you can and cannot make. And what

they eventually said is, well, the only

you can only make three things. You can

make things that are in the USP uh

United States Pharmacopia, okay? Things

that have been, you know, well

described, already published, things

that are already in drugs that are

already on the market, or three, things

that are on a very specific list that

we're going to give you. Okay. And in

that list, they actually included a lot

of these very promising compounds that

were stuck in drug development, you

know, limbo.

>> And you say compoundingies, you said

that a few times. What is a compounding

pharmacy? Just just so I'm clear on the

definition.

>> Back in the 1800s or early 1900s, if you

ever needed a medication, you'd go see

the pharmacist who had a shop down the

road and he would actually make your

medication in front of you and he would

do that custom for every single patient

that came by. All right? And it was only

since the advent of modern factories

that we had the modern pharmaceutical

industry come about. But the truth is is

that again, you know, that's kind of

paint by numbers. You're creating this

one pill and you know, it always seemed

kind of crazy that the adult dose is one

standardized dose for all adults. Like

if you look at what your body

composition is some of my patients, why

is the dose your blood pressure medicine

the exact same? Like that doesn't seem

to be quite right. But it is what it is.

So when patients fall outside of that

and they need custom medication, we

still have those people who make custom

formulations of medications, but instead

of it being just your local pharmacist

who's using a mortar and pestle and you

know is creating something in his back

office, these are now large

sophisticated industrial operations that

can make custom formulations for

patients. I think I think the important

context for people that don't understand

how drug development occurs is that to

get chemicals like the ones we have in

front of us on the table through FDA

approval, you've got to spend millions

and millions and millions of dollars,

>> tens if not hundreds of millions of

dollars.

>> Sometimes hundreds of millions of

dollars.

>> Yeah. An incredible amount of money. And

>> and if you know you can't protect it

once you spend $100 million, you have no

incentive to just do charity work.

>> Absolutely not. Okay. Because you have

shareholders and you have to make

payroll. And so because drug development

is so expensive, there is no incentive

for commercial pharmaceutical companies

to pursue the development of these

compounds. And then on the other side of

that, well, we have compoundingies that,

you know, for them it makes sense. What

if we could just make these compounds

and then sell them directly to patients?

We make a small margin. We sell it. This

makes sense for us. Well, they could do

that starting in about 2014 whenever

that legislation finished. All right.

>> What did it do? Essentially what it did

is it gave a it gave a assignment to

each one of these compounds. It was

either going to be category one which is

you uh can compound this. This is on our

specific list of approved compoundable

drug ingredients. Number two was hey we

see some negative safety signals here.

You cannot make this. Okay. Something

goes on category 2. It's forbidden. And

then we have category three which is we

just need more information. And all of

these original compounds, these peptides

that we're so interested in now were

originally on that first list, category

one. All right? And so they were able to

be compounded. We could prescribe them

patients. I prescribed them to patients.

All right? From 2014 onward. But then in

2023, the FDA at that time switched all

of those peptides, 19 of them that were

popular to category 2. And then they

were banned. Overnight, we got

notifications in our email inboxes from

our compounding pharmacy partners

saying, "Hey, we can't make this

anymore. We're sorry."

>> So, I've got two questions there. Yes.

>> Um, the first is when you were

prescribing these pepsides to your

patient,

>> yes.

>> Were you seeing incredible results?

>> Very much so. Very much. Again, you have

to use the right key for the right lock.

Okay. But I think a really good example.

All right. So, there is a compound that

is not technically a peptide. It is a

small molecule but it was lumped in with

all of these and was the victim to the

same process. Uh something called MK677

also known as ibutamorin. So this is a

small molecule but when a patient takes

it it's orally available it binds to

this receptor called ghrein and it

actually stimulates the release of

significant growth hormone. But what was

really interesting is that it would

actually stimulate hunger a profound

amount. And all of a sudden patients

that were struggling with cexia, okay,

so being very very thin, very

malnourished, maybe they're going

through cancer treatment.

>> Grein's the thing that makes us feel

hungry.

>> Absolutely. Yeah. Yeah. So they were

able to stimulate the hunger response

and patients were actually able to eat

more to meet caloric goals. And so this

was a medication that was fantastically

effective at that. Again, it had gone

through some clinical trials, but was

never taken all the way to commercial.

And so it was never going to be

available from CVS or Walgreens, but you

could get it from a compounding

pharmacy. And so that was one that made

a big difference for us. We also had

other peptides. So, uh, GHRP2 and GHRP6

were some of the ones we were using at

that time. Uh, those are growth hormone

releasing peptides that stimulate the

release of your body's natural growth

hormone, which can help with tissue

repair, can also help with fat loss, and

with building muscle. We also had

BPC-157

and we had uh derivatives like thymus

and beta 4. These are also compounds

that can help stimulate angioenesis, so

making new blood vessels. All right? And

tissue repair. So if we have a patient

that's injured themselves, maybe we

could help them get back at life faster.

These were all things that were used

very commonplace for many years. And

truthfully, they weren't super popular

at the time. We were just using them.

And then they were banned overnight.

>> And they were working.

>> And they were working. And they were

working. We were not seeing adverse

events, which is the most important

thing.

>> What's an adverse event?

>> An adverse event is a patient has a

terrible side effect. They call you,

they have an allergic reaction to

something, they call, they've got

shortness of breath, and it's a direct

result of the medication that you gave

them. It was working. It was working and

by all accounts seemed to be incredibly

safe.

>> And then they banned it.

>> And then they banned it.

>> Why?

>> That's a great question. So officially

what happened is there was a meeting

where they brought together the experts

at the time and they said there is

insufficient data for us to say that

these are safe because again they had

not gone through the full FDA approval

process and so as a result of lacking

that data we're going to say that

they're too dangerous. Now there wasn't

any evidence of any of that in the

population. These were widely used at

the time. potentially we had commercial

pharmaceutical companies saying well hey

this is people spending money on a

compound on something that isn't coming

to us. So hey like we love medicine but

maybe only when it's our medicine.

>> And so there's concern that that was at

play as well. And so there's not a great

paper trail and there's not a great

explanation why. And that's something

that's been iterated by our current

administration from RFK himself. You

know, he himself has characterized that

move done in 2023 as being illegal.

>> With everything you know about the

medical industry, do you think it is

plausible that big farmer

>> 110%.

>> Didn't want

>> 110%.

>> These in the hands of regular people

because they can't patent this and it's

powerful.

>> So ultimately the way to think about it

is this. Um,

pharma may not have a compound that

directly competes for BPC57.

>> BPC-157.

>> So, this is the medication or the

peptide that can aid with healing after

an injury. Okay? So, it's not

necessarily there's direct competition,

but at the end of the day, your average

patient going throughout their daily

life only has so much money that they

can spend on medicine. and $10, $15,

however much money that goes to this

doesn't go to a prescription drug from a

commercial pharmaceutical company. And

so there is real concern that

potentially that was at play during that

decision. And

>> you said 110%.

>> Yeah. I Well, you know, it's interesting

because, you know, I try to walk a very

fine line between what I can prove uh

versus what I suspect after being in

this space for a long time. And you know

ultimately you know I don't think it's

accurate to characterize pharmaceutical

companies or really any other entity as

being you know evil or or bad. The truth

is maybe a little bit more ominous. The

truth is is that they are these large

machines that are designed to prioritize

profit over everything.

>> Yeah.

>> And that's everything.

>> I think this is one of the really

interesting observations I've had the

higher I've gone in my career is that

often times you we heard about the

Illuminati. Like when I was growing up,

I was like, "Oh, there's this

Illuminati."

>> And you think of it as these like shadow

hooded people that get together and

decide evil things. But the further I've

gone in business, the more I've realized

that the Illuminati or these evil forces

are actually just machines that were

designed to optimize for profit.

>> Correct. Correct.

>> So like corporations are the Illuminati.

>> Yeah. And so I don't actually think that

there's necessarily, you know, a a group

of maniacal individuals, you know, the

Legion of Doom, you know, plotting to

like take away your health. But at the

same time, I think that there are these

large organizations that really couldn't

care less about your health. You know,

they are prioritizing what's important

for them. And regular people just get

caught up in the mix. And what's

challenging is that as a physician, you

know, I took a hypocratic oath. You

know, I care about my patients. And so

those are the people that are in front

of me every single day that are seeking

to improve their lives to recover from

injury. I have, you know, fertility

patients that are just dying to start

their family. And I have patients that

are suffering from hormonal imbalances

that haven't felt right in years. I I

treat erectile dysfunction in men that

have been struggling for years after

prostate cancer treatment. I mean, these

are people that are broken and hurting.

You want to be able to help them. And

so, I feel that is a very strong

personal calling that I have to be that

advocate for that patient both in the

room whenever I'm treating them and

taking care of them, but also when I'm

talking to others and I'm, you know,

speaking out about these issues. like I

want access to these medications because

I care about the patients who benefit

from them.

>> So they banned these peptides that we

have here,

>> correct?

>> And we're sat here 2 years after the

ban, I believe, roughly 2 years after

that ban.

>> Yeah.

>> And suddenly everybody's talking about

peptides again.

>> Yes.

>> Why? What's going on?

>> So I think what we're seeing is the

forbidden fruit effect because this was

banned and all of a sudden, oh well,

why'd they ban it? Well, they wouldn't

have banned it if it weren't working,

right? And we're also seeing the effect

of Tik Tok and short form content being

spread very rapidly, very virally. And

that's been going on for two years now,

combined with new uh emphasis from

administration leadership and HHS and

RFK.

>> What is the most incredible

impact that you've seen peptides create

in a patient?

>> Oh my gosh, I have the best story for

you. So, one of the most frustrating uh

things about my practice is treating

infertility in young men that have

significant metabolic dysfunction. These

are young men that have a low sperm

count, right? So, they can't get

pregnant because they just don't have

the numbers to make it happen. And

you're looking at them and they're

morbidly obese, okay? They have high

insulin resistance. All right? And their

endocrine system has been damaged by

that obesity. So they don't have have

low testosterone levels and their brain

is not making enough of the signals to

stimulate their testicles. Now we have

medications that we can use to help

stimulate that to make more of that

signal stimulate the testicles, right?

But really what is eating at them, what

is causing this is not that chemical

imbalance. That's the the symptom.

That's not the the problem. Okay? And

treating symptoms doesn't really get you

very far. And so I would have patients

that I would take care of and we would

never see a significant improvement in

their numbers because losing weight is

really really hard. you know, regardless

of all of the education and resources I

try to give them. But now we have

peptides in the form of GLP-1 drugs like

simaglutide and tzepatide. And I just

saw a patient le last week who increased

his sperm count 10 times over and is now

in a normal range because he's lost 100

pounds due to using tzepatide,

exercising, and improving his diet. And

he has totally changed his life.

>> And that started with a peptide.

>> It started with a peptide. So I we've

got lots of peptides on the table in

front of you. We will go to into them

individually, but just can you give me a

a highle view of the types of areas in

our health and life that these peptides

can help with? So we've talked there

about infertility,

>> correct?

>> As a downstream consequence of the like

weight loss and fixing metabolic health,

what what other parts of the body do

peptides touch?

>> The best way to think about it is like

this. So peptides are almost like an app

on your phone. So imagine before we had

apps. Like I I'm old enough to remember

trying to log on and do my banking

online before we had apps. And gosh, it

was so painful, right? Like there were

ways to accomplish things, but they were

very inconvenient and in a roundabout

way. And now all of a sudden, we have

these apps on our phone that can do just

about anything except fold your laundry,

right? You know, there's some limits to

it, but I mean really the sky's the

limit from an electronic standpoint. And

really, that's what peptides are. So the

thing is is that we have peptides that

can help you lose weight, like the GLP-1

drugs. We have peptides that can improve

skin quality like uh GHKCU.

We have peptides that can help heal your

gut like BPC 157 particularly effective

in ulcerative colitis which is something

that's being investigated with the FDA's

planned upcoming meeting on it. We also

have peptides that can help with sleep

and with uh recovering the gland in your

brain that's responsible for melatonin

and regulating your sleep wake cycles.

So the question isn't you know what can

peptides do? kind of well what can't

they do and if they can't do that yet

can we develop a peptide that can

accomplish that task and the answer is

probably and simultaneously while there

may be resistance from pharmaceutical

industry in these peptides the ones that

we're most interested right now they

have signed multi-billion dollar deals

with other pharmaceutical companies that

are involved in peptide uh development

aided by AI to try and fasttrack their

own peptide uh products

>> interesting

>> and so we are going to see exponentially

more of these products come down the

pipeline from pharmaceutical companies

in the form of commercial products.

>> And it's worth saying that there was

some significant news today.

>> Correct.

>> What happened today, but also what's

going on. And just for anyone that

doesn't know, it's April the 15th.

>> Yes. So today uh we got a press release

from the FDA saying that in July they

are going to consider seven peptides for

removing from category 2 back to

category 1,

>> legalizing them.

>> Legalizing them. Okay. And uh some of

the heavy hitters from that list include

BPC uh 157,

>> which is the one we talked about to do

with like repair and injury.

>> Absolutely. Okay. And then we have uh

the brother to that, which is TV500.

This vial over here, this improves blood

flow to an injured area. You could think

of this as sending the soldiers as

sending the cells that are required for

rebuilding that tissue matrix that was

damaged by a tear or a cut. All right.

On top of that, uh we're also getting

something called uh KPV. May not have it

here, but that is another uh peptide

that has been linked to angioenesis and

tissue repair. We're also getting MOT C

and you know, some patients will call it

exercise in a vial. It improves your V2

max and your exercise tolerance. And by

up uh regulating the energy pathway,

basically making more ATP, the energy

that we all use to move, it makes more

of that available. All right, we're also

going to get DIP, epylon, and CAX, which

are all peptides that affect cognitive

function. So, improving thinking like uh

CAX is a great option for that. And then

DIP and epylon both have roles in

regulating uh sleep and recovery.

>> Wow.

>> Yeah. Pretty wild.

And I've got to say, how does So, some

of them are becoming legalized, but even

the ones that aren't legal right now, a

lot of people are taking them anyway.

>> Correct. So my my question is how are

people getting them? Listen, I don't

want to promote illegal drugs here. This

is not that kind of [ __ ] but I just

want to know what's going on.

>> No, this is well this is important to

talk about, right? We have to understand

like what's going on in the marketplace.

The moment that these drugs were banned

or these medications were banned in

2023, it was kind of like the United

States experiment at banning alcohol, it

didn't go very well, right? All of a

sudden, you know, they we, you know, the

mob came around and we started, you

know, seeing unregulated uh uh saloons

and unregulated alcohol production and

it was contaminated with all the stuff

that you didn't want. And so we're like,

>> people are traveling.

>> Yeah. Exactly. It's just it's not a good

idea, right? And so what happened is we

banned these and the gray market stepped

in. And so these are companies that will

sell peptides that have on the label for

research use only. All right? And the

idea is that that takes them out of the

FDA's jurisdiction because they're not

selling it for people to inject into

themselves, out of the FDA's hands. I'm

just creating a vial of this magical

juice that you can use for your rat.

Okay, that's the idea. We all know

that's not what's really happening. But

because there isn't any quality control,

it's kind of like getting gas station

sushi. Like, yeah, you can do it, but

you don't really know if it's sushi, and

it may not end very well for you. And so

again, not saying that there aren't some

people who have gotten good results with

research use only peptides, but again,

it's not standardized, which is why I

think moving this back into the 503A

compounding world is the best thing for

everyone,

>> which is the legal framework. Okay, so

how does one take a peptide?

>> That's a great question. So what's

interesting is that, as we mentioned,

you know, peptides are just made up of

building blocks of amino acids. And you

know, if you were to go make yourself a

uh protein shake, you know what is that

gonna look like from a Lego standpoint?

It just looks like this. A handful of

Legos in your hand, right?

>> All sort of ground up.

>> All ground up in individual pieces,

right? And the thing is is that your gut

is designed to break up any sort of

protein that you ingest orally into

these little pieces. And so if you were

to say, I don't know, drink some of, you

know, this TB500, your body wouldn't be

able to tell the difference between that

and a piece of chicken

>> cuz it would it would break it all

apart. break it all apart. Now, there

are some very uh unique exceptions to

that. There's a form of BPC157 that

actually is tolerated in the gut, but by

and large, the overwhelming majority of

these have to be injected either

subcutaneously or into the muscle. And

that's usually a preference.

>> Subcutaneous being my belly

>> under just underneath the skin. You

know, as I tell patients, just pinch an

inch, inject under the skin. We do that

for a lot of other medications as well.

>> Is that what this is?

>> Yeah. So, this is a prescription MARO

pen. So, Mangjaro is the brand name for

Tzepide. All right, trespatide being the

leading GLP-1 product right now from

Lily. So, this produces more weight loss

per milligram than any other product

that we've got out right now.

>> Is this the mechanism in which people

inject peptides?

>> No, a little bit different. So, this is

an auto injector pen. And so, what you

do is you're able to actually ratchet

the dose there on the right side and

then you pinch an inch in your skin and

then push it up against and it'll

autodeploy. And so, there's nothing that

you need to do. You don't have to learn

how to drop medication and inject.

Whenever you're administering peptides

at home, especially for patients that

have obtained them from research use

only markets, they usually come in just

little vials that need to be drawn up

with a needle. Okay? Now, the benefit of

that is that you can do custom dosing.

All right. But the drawback is is that

well, you have to know how to calculate

that and put it together. This may be

the most controversial thing we have on

this table. And by farmer's estimate, it

might be the most dangerous thing to

their entire business model because this

is trozepatide, the exact same thing

that you had in that pen. But this is

made by a highquality 503A compounding

pharmacy. And the reason why this is uh

so controversial right now is because it

offers an incredible amount of

flexibility because what you have in

your hand there is very standardized and

you administer it once a week because

that's what's approved by interest.

>> This is like the thing everyone's been

talking about.

>> Exactly. Yeah, but think of that as

paint by numbers. Okay, you are this

section is this color. This section is

that color. All right. Think of this as

>> the thing you've got in your hand

>> right now. Yeah, exactly. Just a vial of

trapide as being a having infinite

permutations and dosing ability because

you can draw this up with a small

syringe and do micro dosing. So instead

of one large dose once a week because

what many patients will experience is

they'll have a return of their hunger by

the end of the week and they end up

losing ground. You can actually instead

of doing a full dose once a week, you

could do multiple mini doses throughout

the week with this formulation and with

this presentation of the medication. All

right, but the challenge is is that that

is the benefit that allows this to be

compounded by compoundingies because

they are able to provide something that

is similar to what's in your hand. All

right. But it offers more flexibility

that may be the right choice for some

patients. So personaliz personalization

of medicine. Okay. But the challenge is

is that if you spend however much money

on this, you're not giving it to Lily.

And so as a result, we have seen an

unprecedented crackdown in the United

States from the FDA and trying to shut

down compoundingies and prevent them

from making these medications. Even

though that ability to customize the

fact that this is not an exact copy of

what's in your hand right now should

protect it under current legislation,

but there is now enough pressure from

the powers that be and from lobbyists

from both Lily and Nova Nordisk that

which are the two companies that make

the GLP-1 medications that we're seeing

Marty Macher the FDA commissioner has

now tweeted more about cracking down on

compounded GLP-1 medications than he's

tweeted about diabetes. disease or heart

disease in his entire time in office.

>> And just so I understand, I want to play

this back to you to make sure I

understand.

>> Sure.

>> In my hand here, I have

Tepatitide on my left.

>> And this is made by Lily, which is a

corporate company who've patented it, so

they can make lots of money from it.

>> Correct.

>> In my right hand, I have tepide

with nycinomide

>> with nyinomide. Y

>> and this is not patentable. So Lily has

a patent on the trazepatide molecule in

that formulation in your hand. Okay.

>> And if anyone violates a patent that can

be pursued in US court. Yeah. Patent

law. Right. But what's interesting is

that Lily and Novo Nordisk know that

that's different in your right hand. It

doesn't look the same. You can dose it

differently. And they know that if they

were going to fight that in court, it

would cost a lot of money and take a lot

of time. So, you know what's a lot

easier? Calling your friend at the FDA

and getting him to step on the

competition so you don't have to. And

then who's paying for that enforcement?

It's not the lawyers that the pharma

company is paying for. Uh it's the

taxpayer paying for the FDA through

taxes.

>> And you seem to imply that this was

actually better because you could take

it in a more flexible dose. You could

take a little bit, a lot, you can take

it when you want. Whereas this is kind

of once a once a week.

>> Well, I mean, you know what is better,

right? So I like this option for many of

my patients because it's flexible. All

right, so that is something that works

for most patients. All right, but then

then again, this works great for

patients too. Okay, but what you want is

you want an ecosystem where you have

choice so you can make the right choice

for the right patient. For a lot of

patients, they're going to do

exceedingly well on this. And there's so

much data to support that. But I also

have a lot of patients who get really

ill after they do a large dose of

Mangaro or of GLP-1 med. And if we take

that same dose and we just cut it into

multiple doses within a week, we can

avoid those side effects.

>> So you've told me that these peptides we

have on the table in front of us can

improve your skin, weight loss, muscle,

energy, chronic illnesses. You talked

about the cognitive upsides and you talk

about it very passionately.

>> Yeah.

>> So one should ask you presumably you're

taking some peptides.

>> I am. Yeah. So

>> which ones do you take? So I will tell

you that as of right now the only

peptide I'm taking is a small dose of

tzapatide. All right.

>> Which is the one we were just talking

about.

>> Yeah. Okay.

>> Because back uh couple of couple of

months ago I was probably close to about

240 or so and I was into powerlifting.

You know I still am. But you know it's

really great to be able to deadlift 500

lb. But then stairs become really hard

when you're trying to walk up and you're

like I don't know. I kind of like uh

being able to not take a break after two

or three flights of stairs. And so I was

like, "Okay, all right. Longevity is a

priority of mine. I'm going to slim down

a little bit." I like, "Let me just try

this for a little bit." And what I found

is that it is incredibly potent and at a

very low dose, very, very tolerable.

>> Why didn't you take some of the others?

>> Honestly, because right now there is not

a legal framework for me to obtain them.

And the truth is is that I want to be an

example for my patients. And that's why

I'm out here advocating that we get

access to these peptides in a legal,

safe way again. All right? And because

it's it's the best thing for everyone.

>> If they were legal, which ones might you

consider?

>> Oh, man. I will tell you this as some

like I I don't know how old you are,

Stephen, but I'm 33. God bless you. I

will tell you once you get over 35, man,

that is brutal. All right. I sleep on my

neck in a wrong way and I need like a

freaking brace for like two weeks. And

so, as someone who spends a lot of time

in the gym, you know, working out, like

you start to accumulate all these little

aches and pains. And so the idea of, for

example, I have a a very finicky right

shoulder. If I try to do a really heavy

bench and I haven't warmed up, I can

tweak this and it takes me out of the

fight for at least a month, okay? And I

have to do other things. You know, I

would have killed at various points in

time over the past two years to have had

BPC and TB500 to hopefully speed that

sort of healing. All right. Um, also,

for example, I suffer from really bad

rosacea. It flares constantly.

>> What's that? So, just a redness of the

face, okay, that you know, it makes me

look like I'm sunburned. And then I come

in on the office on like a Tuesday and

then my staff's like, "Oh my gosh, you

go out in the yard and do some work this

week." I'm like, "It's just my face."

Um, you know, for example, that's

something that a lot of people have

reported benefits from GH KCU from. So,

again, another compound, another peptide

that could be beneficial for a patient

like myself.

>> What about muscle mass and gaining

muscle? Yeah. So, that is an interesting

misnomer because that has been a common

selling point you'll see on social

media. But as of right now, the only

peptide that you might construe that way

would be this guy right here in my hand,

IGF-1 LR3. Okay. Now, IGF-1 LR3 is

basically the longerlasting version of

IGF-1, which is the downstream effect of

growth hormone. I'm sure you've heard of

bodybuilders taking growth hormone to

increase size and, you know, lose fat.

In higher doses, it can help contribute

to muscle uh mass. All right? But

truthfully, if you're trying to gain

significant muscle mass, this is this is

not the way to do it. And so, the right

now, one of the things that peptides

can't do for you is independently put on

significant amounts of lean mass.

>> You still have to go to the gym.

>> You still have to go to the gym, believe

it or not. And guess what?

>> Well, that's the end of the podcast.

>> Yeah. I I'll tell you. And but something

that blows my mind is that I have so

many patients that think that they can

just take testosterone and just put on

muscle naturally. And it doesn't work

that way. You might get a tiny little

bit, but you still have to have

stimulus. You still have to get in the

gym. You still have to put the work in.

And so I tell patients that I am not a

replacement for a personal trainer. I'm

your doctor. You also need your personal

trainer. And most of you need a

nutritionist, man. And so I'm lucky to

work with some great people in the

community who partner with me on that.

But you know it's a it's a fullcourt

press when you're trying to get people

to you know live the highest quality of

life.

>> What about some of these metabolic

disorders and diseases in terms of like

insulin yeah resistance? People on the

di the audience are very interested to

learn about insulin. I see that a lot in

the comments section and a lot of the

data. Yeah.

>> So how can if someone's struggling with

their insulin levels or their you know

their glucose response how does these

peptides help?

>> Honestly the best peptides for that

right now are the GLP1 drugs. Okay.

Hands down. because what you're doing is

you are slowing gastric emptying and so

you have a slower absorption of that

bolus of food that you've eaten so your

glucose doesn't spike and so as a result

that increases insulin sensitivity

significantly. Now again you have to be

careful about what peptide you're using

for what. A lot of these peptides that

boost growth hormone and boost let's say

IGF-1, those can actually increase serum

glucose and that may not be what you

want if you are someone that is trying

to work on your insulin sensitivity.

>> And do any of these peptides come as

like creams or as pills or anything like

that? If you look online, you can

probably find a version of everything.

But if we're talking about actual

legitimate formulations, the best

example of a topical cream is going to

be GHKCU. And this is interesting

because this is a copper tripeptide that

has been found to decrease in expression

and concentration as we age. But when it

is applied topically, it's highly

effective topically. So putting on a

cream on your face. All right. It's been

found to be extremely beneficial in

regenerating the quality of skin. So,

complexion. All right. Increasing the

amount of collagen and elastin, the

things that we need to keep our faces

taut and youthful. The things that

people will pay lots of money to go get

lasered to get improvements. Not that

it's a replacement for that, but that's

a topical form that believe it or not,

you could go out and buy today because

topical GHKCU is regulated very

differently than the injectable form. Is

it expensive? Usually,

>> you know, growing up, I thought all

these sort of anti-aging creams were

[ __ ]

>> But but you're telling me that this has

actually been associated with improving

signs of aging.

>> I will tell you this, when I was going

through college and medical school, I

was the biggest skeptic. Like, I did not

believe any of the health or wellness

claims that we saw coming out at the

time. And again, you know, that was at a

time where we were getting bombarded

with stuff about the Atkins diet and

this that or the other. But then all of

a sudden you start having patients come

back to you and they're testifying as

the benefits they've seen from these

things. You start to actually look at

the biochemistry behind them and you're

like there's a lot of science backing

this up. This isn't just mumbo jumbo.

And so believe it or not, yeah, there

are creams that can slow the process of

aging at least from a visual standpoint

when it comes to your skin. I have yet

to figure out anything that uh you know

makes me as energetic as I was in my

early 20s, but you know I'm working on

it. Mhm. But on that point of energy and

cognition, if I wanted to become a

better podcaster. Yeah.

>> And you know, I sit here sometimes,

sometimes we do two in a day, which

means I might sit here for eight hours.

Once we do, I think a couple of times

we've done three in a day.

>> That's brutal.

>> Which is 12 hours of recording. Yeah.

>> But what would you recommend if I was

trying to improve my cognitive

performance? So again, as a physician

who likes keeping my license, I wouldn't

say necessarily recommend, but I would

say if we're looking at how these

medications have been used and

potentially one that may be legal again

coming this July depending what the FDA

says, intraasal CAX. And this was one

that was originally studied actually in

Russia many years ago. And what they

found is that this seven amino acid

peptide when it was administered after a

uh TBI, so a traumatic brain injury, all

right, or acute injury, that patients

tended to bounce back faster. Also, they

saw evidence of it improving outcomes

after stroke. And it also seems to

upregulate the same sort of factors that

help with cognition and with, you know,

connecting sentences and bits of data in

your brain. And so it's also one of the,

interestingly enough, one of the ones

that is available, you know, intraasally

because it goes through the mucous

membranes and gets right where you need

it. And so that's going to be a really

really fascinating uh compound to see

back on the market. And then we can

actually get more data regarding

efficacy and across a wide population.

>> So interesting. And you you sniff that

through your nose.

>> Sniff like you would for any nasal

decongestant, right? And if you have

allergies or something like that. Also,

for someone like yourself, you travel a

lot. you know, you're going in between

different time zones, you're balancing

multiple obligations at different odd

times of the day. I I shudder to think

what your circadium rhythm looks like,

my friend. Um, but you know, that is

what we have some of these other

compounds that are uh going to be

available for. So, if we look at uh uh

dip, okay, that has been shown to be

helpful with regulating your circadian

rhythm. All right, that is one of the

ones that's going to be approved

hopefully here soon again in July,

right? And then you know on top of that

um you've got you know uh things like

selen which is another one that can help

calm you as you're going to sleep about

an hour ahead of time and again hope

help those you know deep delta wave

brain waves that are so restorative

whenever you actually are you know

resting.

>> Where will we be able to buy these when

and if they are legalized?

>> So from

uh 503A compounders here in the United

States with a prescription from a

physician.

>> So you still need a prescription. still

need a prescription. Correct. It's

>> going to be quite a crazy world when

everybody seem is going to be injecting

themselves every every day. I mean,

we're already getting to that point now

with the Zen where I've got loads of

people in my my friendship group that

are

>> Yeah. And they're Yeah. And they're

doing great.

>> Yeah. They're doing great.

>> They're doing great. And that's what I

like about, you know, the advent of

these GLP1s is they're removing the

stigma of a needle.

>> And I look at some of my friends who

have been on it. I can't recognize them.

They look awesome.

>> Are you concerned with with any of them?

You know, I've got a couple of friends

in my circle where I'm I'm a little bit

concerned. I don't even know if I should

be concerned, but it's just when you see

someone, you know, change so

dramatically, so quickly.

>> Yeah.

>> I think there's something in us which

something prehistoric in us which goes,

"Oh my god, there's a problem."

>> Yeah. One thing I'm I am concerned about

is the rapid weight loss with GLP-1

medications. Because the problem is is

that when you go into such a radical

caloric deficit, your body goes into

catabolism, which is breaking down

tissue. And you want to break down fat,

right? But your body isn't that

judicious. It's going to break down

muscle. And muscle is the most

metabolically important tissue that any

of us have. And so if you really want to

optimize your insulin sensitivity, well,

you need to maintain your muscle. And

right now, really the only compounds

that we have that are really good at

preserving muscle with resistance

training is testosterone, right? But

that isn't going to be a good option for

our male patients that want to get

pregnant because testosterone turns off

fertility in men. All right? It's also

not a great idea for our female

patients. All right? depending on their

age, testosterone, TRT is a thing in

older, you know, uh, women, menopausal,

won't go into that. But truthfully,

testosterone is not the right answer for

everybody. And so, what we are going to

see come down the pipe very soon is kind

of the older brother of peptides, the

more complex form, biologics, called

monoconal antibodies that are

specifically designed to inhibit the

enzymes that break down muscle. So,

these are specifically called myatin

inhibitors. There are three that are

coming down the uh pipeline. There is

one called bamagrammab which is owned by

lily that is going to bind to the peanut

butter to myastatin jelly which is

called actin. And then you have mab and

travogumab which are two other compounds

owned by a different pharmaceutical

company that are all designed to

maintain muscle even in a significant

caloric deficit.

>> This is getting interesting now.

>> Yeah. Yeah. So you're you're telling me

I'm going to be able to inject myself

with a zmpe to lose the fat and then

inject myself with something else to

keep the muscle.

>> It's wild.

is wild

and and I will tell you, you know, one

of the hardest things that I'm sure

you've heard being on the receiving end

of this is just the complexity of it.

And there are so many levers that are

moving at once and trying to get your

head around it and balance it all. Like

it requires nuance and it requires a

thoughtful discussion with your doctor

who is well educated on them. And that's

one of the challenges is that there

isn't broad great education on these

products right now in the medical space.

And so that's something that I'm very

passionate about is improving education

across my colleagues so that they're not

afraid of these anymore.

>> What do you say to people that are

listening to this now go, "Fucking hell,

why don't you just like eat your greens

and go to the gym?" Yeah.

>> And just be more human and you'll be

fine.

>> I love that. I love eating your greens

and going to the gym. Okay. Um but the

unfortunate reality is that here in the

United States, it depends on what

database you look at, but obesity rates

are estimated to be 40 to 70%. Okay?

whether you depending on what BMI cut

off you're using. Okay, BMI is not

perfect, but it is what it is. And so

the thing is is that well eating greens

and going to the gym are not working for

us as a society. And we could talk about

how we don't have real food anymore. We

have food deserts. We have this nut

calorically dense but nutritionally poor

food. I'll tell you the most disturbing

thing I see as a surgeon is I'll see a

patient come in the door and they're

morbidly obese. They're a large

individual, but I have to do surgery on

them. But the connective tissue, the

stuff that's made up of protein that

makes them them, that literally holds

them together, is paper paper thin

because they're eating an incredible

amount of calories. They're gaining fat,

but they don't have any protein in their

diet. And that's not something that's

rare. I see that on a daily basis. And

so the truth is is that, you know, we're

talking about this from the angle of

biohackers and people that are super

engaged in our health. But the truth is

is that this is going to be able to be

used to help our population at large.

and you know ultimately hopefully avoid

a lot of the terrible disease states

that we're seeing overwhelm the medical

system right now.

>> How big is the peptide industry right

now?

>> If we look at the top four large

language models companies, all right, so

all the heavy hitters and how much

revenue they're generating, it's

estimated between be between 58 billion

up to maybe 62 billion. Yet the income

and the revenue from just simaglutide

and tzepatide alone is going to be over

55 billion this year. And so what we

have is peptides without even

considering all of this happening in the

research space or the research use only

space without even considering the

peptides that uh we'll see come from

compounding pharmacies. We're already

approaching parody with what we're

seeing in AI as far as revenue goes.

That is the demand that we're seeing in

the marketplace. I run multiple

companies that have multiple sales teams

and one of the things as a founder of a

company that's often confusing is you

find it hard to figure out where sales

are. So about 10 years ago I started

using Pipe Drive in my former company

and it's also the reason why I switched

over all of my commercial teams in my

current media company called Steven.com

to use Pipe Drive as well. Not only did

they sponsor this show, but they've been

an incredibly effective way of scaling

our sales engine over the years. Pipe

Drive is an easy to use intelligent CRM

and at its very core it makes your sales

process visible through one dashboard. A

visual pipeline showing every deal, what

stage it's in, what needs to happen

next, and it's all in real time with no

delay. It doesn't magically close the

deal for you, of course, but it does

replace complexity with clarity. If you

want to join over a 100,000 companies

already using Pipe Drive, you can use my

link for a 30-day free trial with no

credit card payment needed. Head to

piperive.com

to get started. That's piperive.comceo.

I'll see you over there.

>> When your patients come and see you, Dr.

Alex, what are they asking you most

frequently as it relates to peptides?

What are like the top three questions

you get asked the most?

>> The first thing I get asked is, "What

peptides do I need?" And then I just

look at them. I'm like, "What's your

problem?" You know, like what's

bothering you?

>> And what do they say? you know, and then

they'll come in and they'll start

talking about energy, sex drive, and

that sort of things. And I'm like,

"Okay, if that's it, well, we need to

check your testosterone levels,

brother." Okay? So, instead of looking

for peptides, right? You know, you don't

walk into a Home Depot or a Lowe's. You

like, "What tools do do I need?" And

you're like, "What are you trying to

do?" Right? And then you start to talk

to someone there like, "Well, I'm trying

to build this." Okay, you need a saw.

You need a screwdriver. You need this.

And some of those tools might be

peptides. All right? But some of them

may be hormones. You know, some of it

may be diet and exercise. And so

peptides are just another type of tool

that we can use.

>> We all want a shortcut though, doctor.

We all want a quick way to to be better

and ideally not to have to do hard work.

That's like what most, you know, the

average person is looking for. And we

hear about these peptides. We hear other

people are taking them. We hear the

fantastic results in skin, hair, muscle.

And we go, "Fucking, what about me?"

>> You know what I tell patients? I'm like,

"Me too, man." You know, but my alarm

still went off at 4:45 this morning so I

could hit the gym before I made it to

clinic. Because there are no real

shortcuts. There are things that can

help, right? GLP-1s are the best example

of that, right? Okay, this is the

closest thing to a shortcut you're going

to get. But the truth is is that this

isn't going to go to the gym for you and

it's not going to lift the weight so you

can maintain that muscle mass so you get

the best possible result and try to hold

on to your muscle while losing the fat.

>> One thing I've learned from doing this

podcast that that has really grown with

me over time. People ask me all the time

like, "What's the one thing you've

learned from the podcast?" One of the

answers that I've never given that I'm

going to give now is that I've learned

that there's no such thing in life as a

free lunch.

>> No, absolutely not.

And what I mean by that is like

everything is a tradeoff. And if you

ever hear on a podcast or in any medium

that something has tremendous upsides,

the first question one should ask is

what's the trade and like just with

everything you can apply this to having

a relationship with a partner. Huge

upsides.

>> Also trade-off.

>> Trade-off. Yeah. Yeah. Kids like

>> I love my children. I haven't slept in

years, right? You know, like this is

just this is this is life, right? There

are trade-offs. And even with great

tools, there are trade-offs. So, what

are the trade-offs of these peptides?

>> The biggest trade-off right now is you

don't know if you're even getting what

you're what you want, right? Because

you're ordering this from some research,

you know, uh, compound only. You don't

know whether or not they've gotten out

all the appropriate endotoxins. You

don't know if you're getting what you

actually paid for. So, that's the

biggest thing. And also, the thing is is

that, well, all right, I these have a

good example of, okay, preventing or

helping heal injury. But the thing is

that well we've got other compounds over

here. You know, let's go ahead and like

let's just pull Tessa Morlin as an

example. So this is actually

interesting. It's a peptide that is

commercially available right now. I

could write the script for you. You

could go pick it up from CVS or

Walgreens. Okay, this is available as a

commercial product and people really

like it because it'll help boost growth

hormone and it happens to be uniquely

good at stripping abdominal fat. Okay,

or visceral fat. But the thing is is

that, you know, the moment you stop

taking it for a brief period of time,

well, if you haven't changed anything

about your lifestyle, you're going to go

right back to where you were.

>> It's good at stripping abdominal fat.

Belly fat.

>> Belly fat. This is what it's known for.

Yeah.

>> It's good at stripping belly fat.

>> Stripping belly fat specifically. So,

bodybuilders actually really like it for

that particular application.

>> I had no idea there was a peptide for

stripping belly fat.

>> There you go, man. You know, and like

for example, here we've got another one.

So, this is melanotan 2, right? So this

is a uh melanoorton receptor agonist. So

melano cortins that's what makes you tan

right? So you could administer this. All

right. And it will actually end up

giving you a deep tan in response to

just a little bit of UV sun exposure.

All right. Now I know right. Um listen

I've embraced my pasty whiteness. So I'm

not you know not necessarily my uh my

bag but it's real. Now again there are

some safety concerns with this because

again could that potentially stimulate a

melanoma or something like that? But

this is something again, it's a peptide

that gives a wildly different result

than Tessa Moralin, right? Because it's

a different tan. It does. Yeah, it does.

It'll also give you um uh some of the

most impressive erections you've ever

had in your life. So, uh be be warned.

Um

>> wait, it's literally turning you into a

black guy.

>> IT DOES.

>> FINALLY. YEAH. RIGHT. And it's wild. So

there's actually and there's even a

derivative a melanotan 2 called PT-141

uh bremalanide that is a commercial

product right now that you can write as

a prescription. Okay. But that doesn't

have the tanning benefit but has the

sexual you know benefits.

>> Oh wow.

>> Yeah.

>> Keep those ones over here.

>> We have to talk about this. Another

really interesting thing that phenomenon

that we've seen right is that now we've

got all of these companies that are

making these research use only

compounds. Right. It used to be that you

would have a compound that's in drug

development and you're seeing all the

advertisements for it. You know, maybe

if you follow these sorts of things like

I do cuz I'm a nerd, right? You get

excited about it, but you don't get

access to it, right? Well, believe it or

not, the next blockbuster drug that Lily

is going to come out with probably in

the next couple of months is this guy

called retatride. All right? And

reatride is fantastic in that it is the

first three receptor agonist GLP-1 drug.

So the GLP-1 drugs, okay, whenever

you're talking about semiglutide and

trazepide, they have slightly different

profiles.

>> This is the ampic category,

>> correct? Right. So GLP-1 is the primary

receptor that they work on. And what

that will do is it slows gastric

emptying and it limits caloric intake.

All right. But then inepathide, not

simaglutide, but tepide is a dual

agonist. So it has effect on GIP, which

is a different receptor. Well,

retatrutide adds in glucagon receptor

activation. And so, believe it or not,

your liver actually acts like a

repository of energy where it stores

glycogen and fat that your body can use

as energy. But that's a problem, right?

If you get too much fat there, if you

have a caloric excess, then you could

end up having what's called nash

cerosis, but non-alcoholic stopatitis.

Basically, inflammation of your liver

due to accumulating too much fat. It's a

problem. But by stimulating the glucagon

receptor while simultaneously hitting

GLP-1 and GIP, what we found is not only

do patients lose an incredible amount of

weight, but they also get the best

improvements we've ever seen in their

liver liver health that we've ever seen.

And people have been buying that from

research use only websites and using it

for about two years now. And

bodybuilders have already made this the

standard in their protocol when it comes

to cutting for a show. And it is wildly

effective. And we're now seeing the

population using a drug at scale that

hasn't even made it through

commercialization yet.

>> Why are you smacking you're using it?

>> No,

I have not. I can honestly say I have

not used Retta, but uh I find it

fascinating though. It's absolutely

wild. You know, talk about power to the

people, right?

>> What about these others then? What else

have we got here that you think is

interesting?

>> So um we've got these two here that I

think are really interesting. So CJC1295

and Morland. So the whole idea is that

you know can we stimulate growth hormone

and there's an interesting story behind

that you know actually growth hormone

itself was very very popular for many

many years as an anti-aging compound but

then we changed some laws here in the 19

in 1990 okay that made it a little dicey

to prescribe growth hormone and also you

know it's kind of a blunt instrument we

wanted something to stimulate more

natural growth hormone release so we

have this entire class of medications

called secrets that help stimulate

natural growth hormone release and these

are two of the most potent ones that are

often combined together

>> and when we say growth hormone Yes.

>> What does growth hormone do?

>> So, growth hormone acts like a signal

that tells your liver to make more of uh

another compound we talked about, IGF-1.

What growth hormone does is growth

hormone actually stimulates building

muscle. Okay? It also strips uh fat.

Okay? And uh it's also been found to

help with tissue healing.

>> Okay?

>> And so there's a significant benefit in

that regard. And so people want to boost

their growth hormone. Improves quality

of skin, improves quality of hair and

nails and that sort of thing. And so uh

these two compounds together are

particularly potent. CJC1295

being a growth hormone releasing uh

hormone derivative and then we have uh

epomoralin which is a ghrein receptor uh

agonist. So again release improving the

release of growth hormone through two

different synergistic mechanisms and so

that one is really really interesting or

these two together and then uh on top of

that so this one sematotropen another

word for growth hormone. Okay. So this

is growth hormone. Okay. Just a

different word for it.

>> So what would happen? Let's just take

this one. Somatropen.

>> Yeah.

>> Somatropen.

If I bought this for research purposes,

>> research purposes only.

>> And I started injecting some of this

into me. What would change?

>> So it depends on how much you do and

when you do it. So the idea is that if

you injected that at night, it would

improve your quality of sleep. Okay. You

would get a boost in your quality of

your hair, your skin, nails. Uh

theoretically it'd be easier for you to

recover from injuries, hopefully put on

a little bit more muscle, a little bit

easier, maybe lose a little bit of fat.

>> So why don't I take it?

>> Well, because if you take a little bit

too much, you can actually get uh

insulin resistance because your glucose

levels will go too high for too long.

All right? You abuse too much for too

long. You will actually get acromegaly.

So that's development of the your bones

continue to grow, but not along only in

certain junctures. And so there's a very

specific look that bodybuilders who

abuse growth hormone in high amounts

will get to them. All right? which is an

irreversible change to the facial bone

structure. You can also theoretically if

you had a cancer maybe it could make it

worse. All right. Um we've never shown

it that it causes new cancers but that

could be a concern. And you know on top

of that it could give you insulin

resistance because you know you're Yeah.

Exactly right. Um and if you take too

much it could potentially make your

hands numb in the morning because you

get eusions into the joint space. And so

bodybuilders will talk about lifting a

dumbbell and having to drop it because

their hand goes numb temporarily if

they're taking too much growth hormone

too soon.

And what else have we got here?

>> Oh my gosh. So, epathylon. So, this is

uh the uh medication that is

theoretically going to be available to

us in uh July. Okay. And so, uh the hope

is that you know this is going to uh

expand cell life. So, epialon the uh

purpose of it is it works to enhance uh

tomeorase. So, at the end of your cells,

imagine it this way. You're trying to

copy the genome, but the little copier

that copies it, it takes up space and of

itself. So, it's kind of like it cuts

off the last couple letters every single

time.

>> This is when you're aging, right?

>> When you're aging, you're creating new

cells, right? Cells divide through this

process called mitosis where they split.

All right? Well, if you got to make an

exact copy, well, you've got to read

through all these lines of code. But

because of the way that we're built, we

always end up cutting off the last

little bit of code. Now,

>> which is how we age,

>> which is how we age. It is one of the

things that contributes to aging. All

right? Now, that is considered to be

quote unquote junk information. It's at

the very end called the telomeir. All

right? But we know that shorter

telomeres are associated with aging,

potentially worse health outcomes. Then

there's an enzyme that can help heal or

repair the telomeir called tomeores.

Epiolon helps encourage that. And so

some people are looking at that as being

one of the fountain of youth uh

compounds. I'm very skeptical as far as

that goes, but it does show some

benefits when it comes to uh, you know,

healing parts of your brain that are,

you know, associated with regulating

your circadian rhythm.

>> So, the average person listening now,

they've heard a lot of stuff about a lot

of things.

How do they know if they should pursue

getting and taking peptides? Like, how

do they know? What are they looking for?

>> So, what I will say is that think of

peptides as falling into three

categories. All right, you've got

category one which are peptides that you

can prescribe right now legal from you

know a commercial pharmacy that includes

the GLP ones PT-141 bremalanide I

mentioned to you earlier oxytocin is

another one we have these different

compounds that are available and then we

have what we call category 2 which we

don't have anything in right now but

that will consist of the seven peptides

that are hopefully going to be approved

in July whenever they get moved from

category 2 cannot compound to category 1

can compound all right and then

everything else is kind of in this

category three where it's only available

for research use only. And so my

recommendation for patients is don't go

out and buy research use only compounds.

All right? You don't know what you're

getting and you don't know if you're

dosing it right. You don't know if it's

contaminated. So really what the public

should be doing is educating themselves

on this and then going and talking to

their doctors about what problems they

have and then potentially when those

options become available, a peptide

might be part of the answer for their

problem.

>> Okay. So speak to your doctor.

>> Yeah. Consult with your doctor and make

it a conver conversation with whoever

your medical professional is about your

symptoms and what might be useful and

what the range the toolbox the options

are correct

>> to attack those symptoms.

>> Yes, absolutely. Talk collaborate with

your doctor. Your doctor should be your

partner in you getting as healthy as

humanly possible.

>> We talked about um tepatide semiglutide.

One of the questions that's front of

mind for everybody, whether they're

taking them or watching others take

them. Sure. Is what happens when you

stop.

>> We've looked at that, you actually

regain the weight. And so, because the

truth is is that you have introduced

something into your life that has moved

the needle in one direction, but if you

don't change anything else, well, you

take that back out, well, you're going

to go back to where you were. And so, if

you're going to maintain that weight

loss, you have to make lifestyle changes

associated with that. And what we found

is that people do regain if they do make

lifestyle changes, they do regain some

of the weight but not necessarily all of

the weight. And there's also data