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Bill Maris: How Google Could Crush AI Competitors, Why Small Funds Win, and AI's Atari Stage

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Bill Maris: How Google Could Crush AI Competitors, Why Small Funds Win, and AI's Atari Stage

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839 segments

0:02

After [music] saying he was out, now

0:04

Bill Maris is returning to the investing

0:06

world. The founding CEO of Google

0:07

Ventures has raised [music] $150 million

0:10

for his new fund called Section 32.

0:15

>> With a smaller fund, I have the

0:17

advantage to be very selective in the

0:20

companies that I invest in, the people

0:21

that I hire. We're going to invest for a

0:23

financial return. Any other metric is

0:25

impossible to measure and therefore

0:27

won't succeed.

0:28

>> Think of the change that [music] has

0:29

happened just in the last 100 years and

0:31

what's about to happen in the next 100

0:33

years with the advent of AI. The world's

0:35

going to change by orders of magnitude.

0:37

>> Thank you very much for that warm

0:39

welcome. I am Bill Maris. I'm the

0:41

founder of Section 32. Prior to that, I

0:44

was the founder and CEO of Google

0:46

Ventures. I was also Google's Vice

0:49

President of Special Projects where I

0:51

incubated Waymo and Google X, Calico,

0:56

and many other

0:58

projects as well. And before that, I

1:00

founded a web hosting and data center

1:02

company,

1:03

which we're going to talk a little bit

1:04

about.

1:05

And

1:07

today I think I'm going to talk to you

1:08

about a few of the lessons I've learned

1:11

on these interesting experiences I've

1:13

had in life. So, we'll start We're going

1:15

to have four lessons I'm going to talk

1:17

about and we're going to go back to 1997

1:20

to start when I was a fresh college

1:23

graduate. I had a degree in

1:24

neuroscience.

1:25

And I found myself on Wall Street.

1:28

Somehow managed to land a job there, but

1:30

I was miserable having to wear a suit

1:33

and trudge to work in the heat, but one

1:36

good thing came of that, which was I

1:39

looked in the closet of the office one

1:41

day and I saw a server. And I asked,

1:43

"Well, what is this

1:45

thing beneath our jackets?" And they

1:47

said, "Well, that's where our email and

1:50

websites

1:51

live." And And as can happen to many of

1:54

us, I I had a moment where I felt like I

1:56

was bathed in the light of inspiration

1:59

and and I thought

2:01

I thought

2:02

I think I've glimpsed the future.

2:04

Uh I I I I think I can maybe make a

2:06

business out of this because

2:08

if you can have our website and email in

2:11

your closet, how many websites and

2:13

emails could I put in my closet? So, I

2:15

immediately quit my job

2:17

I because I I had I had kind of glimpsed

2:20

through a keyhole and through that

2:22

keyhole I thought I saw the internet and

2:26

I saw a data center and it looked

2:28

something like this or maybe when I say

2:31

data center

2:32

you think of a something like this or

2:34

something like this, but in 1997

2:37

the state-of-the-art data center looked

2:40

almost exactly like this.

2:42

We had three servers,

2:44

a small, medium, and large. Uh

2:47

business grew, we eventually had five

2:49

servers

2:51

and this isn't a data center at all.

2:52

This was my apartment where I founded

2:54

the company

2:55

with credit cards

2:57

and the servers lived in one room.

3:00

The work happened in the other room

3:03

and we get very hot in that room

3:06

and this was in Vermont. So, I opened

3:08

the windows and then we get very cold.

3:10

So cold in fact

3:12

that by noon if you had a glass of water

3:14

on your desk it would ice over.

3:17

You may think though

3:19

this isn't so bad, but but actually this

3:21

was also my apartment as well. This was

3:23

the bed

3:24

and you may look at that and think well

3:27

you've got a mattress and a nice pillow

3:29

and then look at that nice blanket, but

3:30

this is a rug I got from Home Depot to

3:32

keep myself warm on those nights and one

3:35

day

3:36

there was a thunderstorm.

3:37

The roof started to leak

3:39

and I knew I needed to do something

3:42

because water and computers and servers

3:44

don't mix well. So, so I called the

3:46

landlord and said

3:48

the roof's leaking. The landlord said,

3:50

well, that happens sometimes.

3:52

But I knew that I needed to do

3:54

something. So, when you don't know what

3:55

to do, you go to Home Depot. I got a

3:57

bucket of tar and a mop, and I went up

4:00

on the roof,

4:01

and there was lightning, and there was

4:03

rain, and I went up there and I I tarred

4:06

the roof.

4:07

And I did not glimpse the future in that

4:09

case because I didn't know when you're

4:12

tarring the roof that you should start

4:14

at the far corner and work towards the

4:15

door rather than

4:17

the reverse, and I tarred myself into a

4:19

corner, but the choice that I faced was

4:21

either

4:22

the servers get electrocuted, or perhaps

4:24

I get electrocuted, but as an

4:26

entrepreneur, I was willing to take that

4:28

risk, which, you know, news flash, I

4:30

survived. Uh my shoes, though, are still

4:32

stuck on that roof uh in Vermont, which

4:35

takes me uh to uh

4:38

lesson two, which is

4:40

to see the future, sometimes you need to

4:42

be a little bit insane.

4:44

Uh

4:45

it may appear to those around you that

4:48

you were tarring the roof in the

4:49

thunderstorm,

4:51

and to that point, I'm going to share a

4:52

few slides here that a friend named

4:55

Stewart Butterfield was kind enough to

4:57

share with me.

4:58

And here's the inauguration 1989,

5:01

>> [snorts]

5:01

>> and

5:02

there's someone taking a picture.

5:04

That makes sense, probably a film

5:05

camera, and

5:07

2005, it it's not very different.

5:08

There's still someone back there taking

5:10

a picture, and then

5:12

let's go just 4 years later, to another

5:14

inauguration,

5:16

and if we look closely, it's quite a bit

5:18

different

5:19

because now everybody's got a camera.

5:22

Everybody's got a camera, and this was

5:23

kind of before cameras were mushed into

5:26

cell phones. It was kind of around that

5:28

time it was starting to happen, but but

5:29

that's not the most interesting thing

5:31

about this photo because in this crowd

5:33

is someone who, to his friends, I'm sure

5:35

seemed insane, who also did glimpse the

5:37

future. If we look closely,

5:40

this gentleman has decided to, I don't

5:42

know, live stream, or record the

5:44

inauguration on his laptop. Uh

5:47

he knew something that those around him

5:49

didn't know, which is one of the things

5:51

that I've always looked for in

5:52

entrepreneurs is they know a secret

5:55

about the future that most of us don't

5:57

believe.

5:58

Let's fast forward to 2007.

6:01

I find myself somehow at Google.

6:03

Uh and a challenge was given to me.

6:06

Uh the challenge was Google needs a

6:08

venture fund.

6:09

Uh we were starting to make some

6:11

investments. Uh we didn't have a

6:12

coherent strategy. There were no

6:14

budgets. I had to figure out what to do.

6:17

Uh so I

6:18

first found a friend, Rich Miner, who's

6:20

the co-founder of Android,

6:22

uh and he became my partner in crime as

6:24

we conceptualized what what could Google

6:26

Ventures be. Uh we went up and down Sand

6:29

Hill Road and we

6:31

we talked to

6:33

everyone. Anyone that was willing to

6:34

talk to us and have a conversation, we

6:36

were willing to talk to to see what we

6:38

what we could learn.

6:40

Uh

6:41

we came up with a plan.

6:43

Our plan was to obtain all the data of

6:46

venture that we could find. And being

6:48

Google, you can imagine it was a lot of

6:50

data. Historical data, you name it.

6:54

Uh

6:54

then we decided we would as step two use

6:57

AI, but at that time

6:59

Google would not let us use the term AI.

7:02

And this persisted for many years.

7:04

Bill,

7:05

AI is science fiction. It is it's a

7:07

hundred years away if it's ever going to

7:09

happen.

7:10

Uh let's stick to machine learning. By

7:12

the way, when you say AI, it freaks

7:14

people out. So stop freaking So we had

7:17

to call it machine learning

7:18

and we used machine learning to do two

7:21

things: design

7:22

the ideal portfolio construction by

7:25

running millions and millions of

7:26

simulations and back testing and all of

7:29

the things you can imagine that data

7:30

scientists would do.

7:33

And and to determine what the ideal fund

7:35

size would be. And people were excited.

7:39

Here's a headline from TechCrunch at the

7:41

time.

7:43

And and people that inside of Google

7:45

were also pretty excited. This is one of

7:46

the senior execs I later learned had

7:49

this to say.

7:51

And you know, I I have to admit it

7:54

seemed crazy. The plan seemed crazy at

7:56

the time, but let's look at how it

7:58

turned out. So over this time period

8:01

2009 to 2018, top quartile VC returns

8:04

looked like this and top decile looked

8:06

like this.

8:08

Using publicly available information,

8:10

I'm not sharing any

8:11

non-public proprietary Google

8:13

information. We would estimate Google

8:15

Ventures returns at about 4.1x.

8:18

And I

8:20

adhered more closely [snorts] to the

8:22

strategy and the investments that I led

8:24

and the investments that I led turned

8:26

out like this, which takes me to lesson

8:29

three, which is don't bet against

8:31

computer science. I've seen it

8:34

happen many many times and many many

8:36

fields. If you apply the right kind of

8:37

computer science at the right time to

8:39

the right problem,

8:41

you will get to the right answers. I

8:43

would not bet against it.

8:45

Even if it looks like you're tarring the

8:46

roof in a thunderstorm. So let's fast

8:48

forward to 2017.

8:51

I decided to start my own fund. And

8:53

again, those around me said, "You're

8:55

insane. Why would you do that? You're in

8:57

the warm womb of Google. Lunch is free

8:59

and the massages are plenty and so

9:02

forth." But after the idea, you know,

9:04

sunk in, I the advice turned into raise

9:06

as much money as possible. You know,

9:09

that's the right way to run a fund.

9:11

You'll get a big management fee. You'll

9:13

be happy. Things are going to work out

9:14

really well for you.

9:16

And I thought about that relative to

9:18

everything I had done up to that point

9:19

and I decided to to not take that

9:22

advice. And

9:24

over the course of my time at Section

9:26

32, we've had six funds. We've invested

9:29

in companies like CrowdStrike and Cohere

9:32

and Coinbase.

9:34

And all six of those funds have

9:37

averaged

9:38

about 400 million in size and all are

9:40

performing in their top decile. And to

9:43

the extent there is DPI to measure,

9:45

that's the only measure as far as I'm

9:46

concerned in venture that counts is DPI,

9:50

which takes me to lesson four. That this

9:52

is this will be heresy to some, but

9:54

small funds outperform large funds. This

9:57

is simply the math. This is not

10:00

an opinion I'm trying to convince you

10:01

of, but there are many reasons for this.

10:04

Smaller funds you can have more focus.

10:06

You have I mean I've I've already

10:07

managed a multi-billion dollar fund with

10:10

hundreds of employees. It's distracting.

10:12

You cannot give the attention to

10:14

founders that I would like to give.

10:17

It

10:18

There There are many reasons for this.

10:19

And if we look at

10:21

top decile performance of DPI,

10:24

um

10:25

funds smaller than 750 million average

10:28

return of 4.76x and funds larger than a

10:31

billion

10:32

2.42x.

10:34

Funds below 750 million across that time

10:37

period represented 95% of top decile

10:40

performers with discontinuous return

10:42

compression above 750 million.

10:46

Why is this? There's a lot of reasons

10:48

for this.

10:50

You can use your own numbers, but I'll

10:51

just do a little thought experiment. If

10:53

you have a 500 million dollar fund

10:55

and let's say on average these days you

10:57

can own 10% of a company,

10:59

you need 5 billion dollars of exits to

11:02

get your money back. Let's just remind

11:04

ourselves that the 75th percentile of

11:06

venture loses money

11:08

and there is persistence of performance

11:10

of the top quartile. So So if you need 5

11:14

billion to get your money back and and

11:15

if you want to be in this business for

11:17

the long term, let's say you set your

11:19

your goal at 3x, you you need to return

11:21

15 billion dollars of exit value in your

11:24

companies. Now if you have a 7 billion

11:26

dollar fund and we do the same math

11:28

through

11:29

you know, you've got to return 210

11:31

billion. 7 billion to to 70 * 3x is 210

11:35

billion, which uh

11:38

exceeds the total venture-backed M&A and

11:40

IPO exit value in most years.

11:42

Uh

11:43

this year may be an exception, but I

11:45

that is something I'm looking forward to

11:46

talking about when we sit down. For

11:48

those of you we've crunched the numbers,

11:50

we've done all the math. Those are

11:51

Bill's four lessons for today. I hope

11:53

that they're somewhat useful. There's a

11:54

lot of stories behind all this and I'm

11:56

looking forward to talking about them

11:58

for a few minutes with the guys. Thanks

11:59

so much.

12:02

>> You guys are old friends.

12:03

>> Yes, we are.

12:03

>> We go way back. Well, Bill's when he

12:05

started Google Ventures

12:07

I was the first ex-Google

12:11

company you invested in.

12:12

>> That's correct. And

12:12

>> How did it go?

12:13

>> Climate Corp. A billion-dollar exit to

12:15

Monsanto.

12:16

>> What was your multiple? What was the

12:17

return?

12:18

>> Oof, I don't know.

12:19

>> It was actually good for you guys.

12:20

>> It was quite good, yes.

12:21

>> Yeah, you guys were in the B and the

12:22

>> Yeah. It was when billion dollars was a

12:24

a lot of money then.

12:26

>> That back then that was a good deal.

12:27

>> That would have been That would have

12:28

been the seed round.

12:29

>> Like an A round?

12:30

>> Yeah, that would have been your A round.

12:32

Now we're going to do it again with A

12:33

Halo, so

12:33

>> Now we're going to do it again with A

12:34

Halo. Um so

12:37

you know, I just want to juxtapose what

12:39

you said with what Thomas shared.

12:42

They've got a very large kind of capital

12:44

base that they invest and they're

12:46

investing significantly in these later

12:48

stage rounds of these well-proven

12:49

companies where it's, you know, the data

12:51

he shared is that you can get

12:53

significant multiples to get to that

12:55

next phase. You know, you're more likely

12:57

to go from a billion to 10 billion and

12:59

then you're more likely to go from 10

13:00

million to 100 and 100 to a trillion,

13:02

trillion to whatever.

13:03

Um you know, doesn't that justify an

13:06

alternative strategy to what you're

13:07

saying of having smaller funds focused

13:10

on venture that you can maybe barbell

13:11

it, have smaller vehicles focused on

13:14

venture, and then very large vehicles

13:16

that bet on the sure things that have

13:19

that durability and that compounding

13:20

advantage, and you can kind of have the

13:22

two together both be 3x return.

13:24

>> So, my observation on that would be one,

13:27

I haven't seen the data science to

13:28

support that second conclusion of the

13:30

late stage companies that that can be an

13:32

an ongoing trend other than this one

13:35

moment, this weird moment in time with

13:37

these multi kind of trillion-dollar

13:39

exits that are coming. That that would

13:40

be kind of observation one. Two,

13:43

um would be at a certain point and this

13:46

is not a negative, it's just an

13:48

observation. If you're an RIA and

13:50

you're, you know, collecting assets,

13:52

that is not venture. You know, venture,

13:55

as I practice it at least, is a

13:56

different craft where you are making

13:59

concentrated bets of your time and

14:02

capital on entrepreneurs and helping

14:04

them build a business. And there's

14:07

nothing wrong with late stage investing.

14:09

However, I also have a an observation

14:12

that

14:13

I I a uh a bit of an objection to

14:17

uh companies that wrap themselves up in

14:20

public benefit

14:22

language and then

14:24

uh

14:25

keep the value creation uh to themselves

14:28

and an elite group of investors through

14:31

a big part of the curve and then say,

14:34

"Well, we're here to benefit humanity."

14:35

Well, what humanity needs is money. So,

14:37

it would it might be better to go public

14:39

sooner because we'll see how these

14:42

multi-trillion-dollar IPOs go. However,

14:45

if I'm Google and I don't speak for

14:47

Google and I decide to arbitrarily cut

14:50

the cost of, you know,

14:51

tokens to 80%. I'm going to cut them in

14:55

What happens to the business models of

14:56

Open AI and Anthropic at that point?

14:58

>> What happens? Tell us.

14:59

>> Actually, what you know, what does

15:00

happen?

15:00

>> well, if you're a company and you can go

15:02

to Google and Gemini and you can pay 80%

15:05

less

15:06

for that

15:08

basically identical product

15:10

why wouldn't you do that? And then the

15:14

compression and the pressure on those

15:17

other businesses goes super critical.

15:19

>> What are the chances that the other shoe

15:20

has fallen that

15:21

>> might happen.

15:22

>> If I were Google, that's what I'd do.

15:24

>> Walk us through the scenario where

15:25

Google decides with their war chest

15:28

with their money printing machine, you

15:30

know what?

15:31

Their margin is my opportunity.

15:34

I'm going to give tokens out 20 cents on

15:37

the dollar. Every time they lower their

15:38

price, I lower our price.

15:40

What happens

15:42

on the playing field? Walk us through

15:44

that.

15:45

>> Would that not be the rational thing for

15:47

>> It's clear they're going to do it.

15:49

>> Well, it may not

15:50

>> be a margin though to the

15:51

>> They they may be burning investor cash

15:52

sort of like an Uber type model, grab

15:54

market share,

15:56

>> Capital as a weapon, tokens as a weapon.

15:58

>> Token as a weapon, grab market share,

15:59

grab an install base on consumer and

16:01

enterprise. But fundamentally at some

16:03

point, you got to have cash generation.

16:06

>> So that's 100% possible.

16:08

It's 100% probable.

16:09

>> Look, I'll just it's been said before, a

16:11

trillion for spend commitments

16:13

on 60 billion dollars of revenue. And

16:15

now you're going to go to the public and

16:16

hope that retail is going to pick that

16:19

up.

16:20

>> Yeah, tell tell us about companies

16:23

staying private longer

16:25

and how unfair that is to the bottom

16:28

half of society who don't get to

16:29

participate in it.

16:30

>> for those 99% who are mostly not us,

16:33

right? So So your 401, you know, those

16:36

401ks, those retirement plans to get

16:39

into those companies now which are

16:42

getting bizarre exceptions to S&P 500

16:45

rules that they're all of the rules are

16:47

being broken.

16:48

Uh the passive funds, the uh ETFs are

16:51

going to have to pick them up. And where

16:53

do you think we are on that curve of

16:55

value creation? Could they go 3x from

16:57

here? Sure, but

16:58

>> So the

17:00

just to say it as plainly as possible,

17:03

we're going to force overpriced products

17:07

on the 401k holders of America who

17:09

didn't get to participate early. This is

17:11

your position that this is profoundly

17:13

unfair and creates more wealth creation

17:15

for the people who don't need it and it

17:17

makes the people's retirement accounts

17:18

the bag holders.

17:19

>> There's a lot of risk in that and my my

17:22

my objection is don't say you're doing

17:25

this for the benefit of humanity and do

17:27

the other thing.

17:28

>> Make the public's retirement accounts

17:30

the bag holders.

17:32

>> Or just say this is how we're running

17:33

our business and this isn't for the

17:35

benefit of humanity.

17:37

>> Bill, do you think that

17:39

what happens to venture? I asked Thomas

17:40

this question.

17:42

When these dollars get distributed,

17:44

there's going to be a handful of funds

17:46

that have ginormous returns. I mean just

17:49

unbelievably excessive. Founders two,

17:52

you know, is going to print a hundred

17:54

billion dollar return on two hundred

17:56

million dollars of invested capital.

17:58

But that's one fund in isolation.

18:00

>> Right.

18:00

>> Right. And there'll be a few. Your funds

18:02

when you were at GV are going to print

18:04

an enormous

18:05

upside.

18:08

And so if you don't look closely though

18:10

at beyond the averages, venture's going

18:12

to look incredible. If you look past the

18:14

averages, you're still going to look

18:15

extremely bimodal. A handful of winners

18:17

and a ton of losers.

18:19

>> How does that play out?

18:21

>> one, that's how venture is, right? 75%

18:23

of funds lose money. But two, in order

18:26

for Founders Fund or pick any fund to

18:28

get that hundred billion out, they have

18:29

to sell that stock to someone else.

18:31

Otherwise it's just on paper. So who's

18:33

the buyer for that? Is it is it retail?

18:36

Is it

18:37

you know, what

18:38

you've got to make a a business case in

18:40

the public market that can show that

18:42

this business is worth a discounted

18:44

value of its future cash flows. And so

18:47

whether it's SpaceX or Anthropic or so

18:49

forth, like can that case be made? We'll

18:51

see six months after or so. I know

18:54

they're playing with the

18:56

with the lockups to kind of drag that

18:57

out, but we'll we'll see what the public

18:59

market thinks of that.

19:00

>> Okay,

19:01

so we have we have this one set of

19:03

companies

19:04

and then there's everything else. What

19:06

do you like in the everything else

19:07

bucket as a venture investor?

19:09

>> So so I'm going to make an analogy to

19:11

the gaming industry. We all I get asked

19:14

and we all think about, "Well, what does

19:15

the future look like, you know, when

19:17

when AI is everywhere?" And and there's

19:19

doomers on one side and utopians

19:21

>> Zork?

19:21

>> on the other. That's Zork. I'm going to

19:23

get to that. Just just give me Bear with

19:24

me 30 seconds. It's probably not as bad

19:27

or as great as everyone says. So, let's

19:29

look at the gaming industry. So, I used

19:31

to play this game, Zork. There's one

19:32

called Planetfall back in the '80s. And

19:35

it was very brittle. It was turn

19:37

response, turn response. Grab the lamp.

19:40

Oh, I didn't It's a lantern. I should

19:42

have said lantern. Go north. And and you

19:44

wait for the computer to respond. Let's

19:46

show the most sophisticated retail

19:48

available AI system out there today on

19:50

the next slide. And tell me how

19:53

different it looks. So, so what what's

19:55

happened to the gaming industry from the

19:57

'80s to today is going to happen in AI,

19:59

but in the next like five years. So,

20:01

that will be compressed in terms of how

20:03

quickly that change happens. But, we

20:05

would all agree games are better today

20:08

than they were then. They're photo

20:09

realistic. You can like inhabit them.

20:11

And they're they're they're moving very

20:12

quickly. On the AI side, there'll be

20:15

ambient computing. There'll be uh

20:18

The problems that Zork had will be

20:20

solved for AI. Lack of memory, lack of

20:22

consistency, session resets, and and so

20:24

forth. How did we get there? You have To

20:27

answer your question,

20:28

I don't plan on investing in kind of

20:31

larger models, right? Just like wasn't

20:35

uh better stories that would make better

20:36

games. It was controllers and physics

20:39

engines and GPUs and and those are the

20:41

parts of the AI uh cycle that I'm

20:43

interested in, which is which is all the

20:45

platforms that need to be built to

20:47

>> machinery.

20:47

>> You're correct. That is going to make

20:49

this reality real in the next five

20:51

years. And it's not just bigger models.

20:53

I think we're at the Atari command line

20:56

stage of of AI. And we're going to get

20:59

to the, you know, PlayStation 10 stage

21:02

in the next five years.

21:03

>> You uh you also used to do a a of stuff

21:05

in life sciences.

21:06

>> Yeah.

21:07

>> Um not as much anymore.

21:09

Yeah.

21:10

>> My interest in life science, I founded

21:11

Calico and been very interested in that

21:13

space and we were investors in Flatiron

21:16

uh and Veer and lots of other companies.

21:19

Uh I'm very interested in that space

21:21

because it has a dual benefit of helping

21:24

people and also do good, do well.

21:25

>> Correct. However, uh the uh the

21:29

therapeutic space that requires human

21:31

clinical trials is a specialist

21:33

investment area that uh

21:36

we're not uh spending a lot of time on.

21:38

I'm very interested in computational

21:39

biology and and and those areas, which

21:42

is

21:43

>> if you just look on X that there's a

21:44

renaissance happening in human health.

21:46

I don't know if that's true, whether

21:47

it's cures for pancreatic cancer, cancer

21:50

vaccines, peptides, obviously. There's

21:52

just an explosion and a lot of it seems

21:54

to come back to computation.

21:56

Um

21:57

but this class of winners so far is not

21:59

really computationally driven. It was

22:00

just really good science 10 years ago.

22:03

>> Yeah.

22:03

>> And so do you think that we're about to

22:04

see this massive

22:06

>> I hope so. So I started Calico and and

22:09

again it was like fringe science

22:10

longevity at the time. And now we're

22:13

investors in uh um New Limit, which is

22:15

Blake Byers and uh and Brian Armstrong's

22:17

company and a number of other companies

22:19

in that space, which doesn't seem so

22:21

crazy anymore. However, because of the

22:25

human biology and the FDA, if you find a

22:28

compound and you think you've got

22:30

something, that's like 5% of the work.

22:33

We there's still all kinds of titrating

22:35

and safety testing that needs to go on.

22:37

And so I don't think it's going to go

22:39

quite as exponential as we would all

22:41

like it to. However, if we can achieve a

22:44

realistic simulation of a human cell in

22:46

silico, then you will see that

22:48

accelerate as well. We're not quite

22:50

there yet.

22:51

>> But generally we're seeing some might

22:53

say a flight of capital to India and

22:55

China right now. Are you seeing that

22:56

that their biotech path to market is

22:59

faster if you invest in firms that are

23:03

based offshore versus the US.

23:04

>> has always um uh

23:07

indexed on human safety over speed to

23:11

market, and that has cost us in some

23:13

ways. However,

23:16

some other countries are indexed in the

23:18

opposite direction, which costs lives in

23:20

that. So, there's a balance there, uh

23:22

but there are certainly

23:24

there's research going on in China and

23:26

other places, experiments in cloning and

23:28

all sorts of things that that as far as

23:30

I know aren't happening here. Uh so,

23:33

yes, and I think the gutting of the CDC

23:36

and the NIH and and anti-science

23:40

vibe that has now pervades this country

23:44

has driven a lot of mind share elsewhere

23:47

as funding is drying up for basic

23:50

research.

23:51

>> China's got their own paper clip model

23:53

now. They're recruiting some of the best

23:54

scientists from Europe and India, and

23:57

they're all emigrating to China

23:59

>> Yeah.

23:59

>> to go do work, and that used to be a

24:00

scientific pool that we used to access,

24:02

and we used to recruit.

24:04

>> And we're losing We really need the the

24:07

the neurological reserves here.

24:10

Uh and this business with

24:13

>> Or brain trust would be another way to

24:14

say that, but yeah.

24:15

>> well. But the the H-

24:17

the the the pushing out of H1B holders

24:21

like there's so much happening now that

24:22

it's causing it's just easier to go

24:24

elsewhere. That's not good for science.

24:26

>> What's your view on what's been called

24:28

deep tech for the last decade? These

24:30

traditionally long investment cycle,

24:33

capital intensive, high-risk like Elon

24:36

is one of the few entrepreneurs that has

24:38

successfully tackled uh deep tech

24:41

business model with SpaceX and Tesla. Is

24:45

this becoming a more tractable area for

24:48

entrepreneurs to activate and for

24:50

investors to invest in because of AI

24:52

enablement and physics engines and

24:54

>> Absolutely, cuz things are moving so

24:55

much faster. What

24:57

>> like that are you focused on investing

24:59

in?

24:59

>> I mean human biology and healthcare

25:02

that's probably the largest TAM in the

25:03

world. So super interested in that. And

25:06

then all of the others I I mentioned

25:08

that kind of underlay

25:10

the AI revolution which are the the

25:13

physics engines and the controllers and

25:15

the GPUs and the everything that is

25:17

going to take to to get us there.

25:19

>> I want to

25:20

bring I want to bring Sax and Freeburg

25:21

before we run out of time if it's

25:22

possible. Sax

25:24

I'm curious your thoughts on the venture

25:26

capital business. I think you've did

25:28

five craft funds or four?

25:30

>> Well, we've done four venture and two

25:32

growth.

25:32

>> I'm assuming you're going to be going

25:34

back into the venture business. But I'm

25:35

curious your take on when you started in

25:38

venture and when we started as

25:39

entrepreneurs 25 30 years ago, this was

25:42

a much different playing field. What are

25:44

your plans based on you know sort of

25:47

Bill's

25:48

um look at this and do you believe in

25:50

the $500 million fund sweet spot or do

25:53

you think you need to become Andreessen

25:55

Horowitz when you go back to the private

25:56

sector?

25:57

>> Well, I don't I don't think we need to

25:58

become Andreessen Horowitz um but um

26:02

you know, I I look I think fund size

26:05

determines fund strategy.

26:07

And the size of your fund cuz you're

26:09

going to divide your fund size by 20 to

26:12

25 names to achieve some

26:15

portfolio diversification and

26:16

construction. That'll determine your

26:18

check size and that sort of determines

26:20

where you play in the market.

26:22

The thing that's spinning through my

26:23

head after Tom's presentation

26:26

is you know, are you better off just

26:29

focusing on you know, let's call it what

26:33

used to be called I don't know late

26:34

venture early growth. You know, you're

26:36

writing $50 million checks. You just

26:38

kind of wait for the breakouts as

26:41

opposed to playing in this really noisy

26:43

super early stage game. Well, I think

26:45

the problem

26:47

with that is we have to look at the

26:49

incentive structure of venture. So a

26:53

$5 billion venture fund that returns

26:55

1.01 X gets to say that they are in the

26:58

75th percentile and can raise their next

27:00

fund, and no one at the Stanford

27:01

endowment is going to get in trouble for

27:03

writing that check. They need to put two

27:05

or 500 million into a fund multiple

27:08

times.

27:09

So, so I understand that dynamic. So,

27:12

now let's look at the GP dynamic. Well,

27:14

if I have a $5 billion fund, I return

27:17

1.01 X, I'm going to make more money

27:20

than Bill with his $500 million fund

27:22

that returns 3 X.

27:23

Okay? So, that's also a strange

27:25

incentive. So, now let's look at the

27:27

entrepreneur side. I am researcher X

27:30

from Open AI. I'm going to start a

27:32

company.

27:33

Bill says, "I'll give you $20 million at

27:36

a $100 million valuation. I want to buy

27:38

20% of your company."

27:41

Giant fund Y, we're friends, it's a

27:43

different model, but giant fund Y says,

27:46

"Well, we have this giant fund. We need

27:48

to put 250 million in."

27:50

And then an entrepreneur says, "Well,

27:51

but my company's valuation is 100." No,

27:53

your valuation is now 4 billion. And

27:56

we'll give you 250 million for a percent

27:58

of your company.

27:59

They're going to take that deal every

28:01

day.

28:02

Unless you're a seasoned entrepreneur

28:05

who has kind of been down the road and

28:06

knows the pitfalls of that. And so, the

28:08

incentives are broken in all those ways,

28:11

and the pendulum will swing back. So, I

28:13

don't think just staying late stage and

28:16

waiting to snipe her at larger companies

28:19

will be a long-term The The data would

28:20

suggest that's not going to work in the

28:22

long term.

28:22

>> Okay, let's thank Bill. Amazing job.

28:25

>> Thank you.

28:26

Thanks, Bill.

28:27

>> [music]

28:35

[music]

28:41

[music]

Interactive Summary

Bill Maris, founder of Section 32 and former CEO of Google Ventures, discusses his investment philosophy, highlighting the importance of smaller, focused funds, the application of computer science to venture capital, and the shifting dynamics of the AI and biotech industries. He shares lessons from his entrepreneurial journey, emphasizing the need to be contrarian, and argues that small funds historically outperform large ones due to better incentive structures and focus.

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