The Exercise Neuroscientist: NEW RESEARCH, The Shocking Link Between Exercise And Dementia!
2525 segments
In this box is a real preserved human
brain named Betty. And I think you
should hold it.
Oh my god, it's wet.
And now we're going to go through all
the tools and tricks to make your brain
as healthy as it can be. Are you ready?
Wendy Suzuki, the neuroscientist and
professor at New York University.
Her first-hand research on the brain is
helping to improve memory, learning, and
higher cognitive abilities in humans.
Let me start with exercise.
All the research shows the more you
exercise, the more change in your brain
we notice. Every drop of sweat counted.
And the best kind of exercise that you
can do is
What about things that we consume? Food,
drink, and alcohol.
It's all the Mediterranean diet. Go
ahead.
Coffee.
And then my memory's not great.
Most people feel that. But there's four
things that you can do to make memories
stick. Number one is
Is it true that if we have less friends,
then our brain will shrink?
Yes, loneliness damages the brain.
Can you see if someone's in love in the
brain?
Yes, in the side here. A lot of the
reward areas are activated.
Doesn't that mean then that if we don't
fall in love, the love part of my brain
gets smaller? And would that make it
more difficult to love in the future?
That's a great question. So
Wendy, do you have any brain routines?
Absolutely. So every morning I like to
Oh, and then I do the most powerful tool
that you can do to protect your brain
from aging and neurodegenerative disease
states, which is
We've just hit 6 million subscribers on
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Thank you from the bottom of my heart
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and my team love doing so much. It is
the greatest honor of my lifetime, and I
hope that I hope it continues off into
the future. Let's get to the episode.
You just said to me that much of your
work is focused on making sure people
have big, fat, fluffy brains.
Yes.
Why does that matter?
It matters because a big, fat, fluffy
brain is a healthy brain, and
my whole first book, Healthy Brain,
Happy Life, was about how I learned to
use all the tools and tricks and magic
of neuroscience and psychology to make
my brain work better, and I so needed it
at that moment. My life got better. I
got happier. It is a pathway to a happy
life, I think.
Having a very healthy, big, fat, fluffy
brain.
Do you think people appreciate the
importance of their brain?
No. I think they ignore it all the time.
And I think that is part of my part of
my message to everybody that that the
human brain, that is the one in your
head right now, is the most complex
structure known to humankind. Not
Einstein's brain, not Marie Curie's
brain, but the one in your head. And
when you think about that, it gives you
more of a self-appreciation
of all of the computations that is
taking for me to see you and appreciate
your face and be able to remember your
face next time I see you when I go to my
Diary of a CEO podcast and and choose an
episode, all of that is is such a
complex structure. Um you start to
appreciate your own kind of brain
functioning more. I think that's a very
important thing to do.
Why don't we appreciate our brains? Cuz
we appreciate a lot of other things.
Yeah.
We spend a lot of time on our like our
muscles.
Yeah, our abs.
Yeah.
I think that that's a great analogy and
part of my goal is to kind of shift the
focus from focusing on certain body
parts to focusing on what our brain is
doing for us, what it can do for us, and
what we can do to change our
environments to get to that big fat
fluffy brain, to get it healthy, to get
it happy, to get it growing.
If I achieve a big fat fluffy brain,
how would my life be different? I'm
saying me, Steve Bartlett. I'm a
podcaster, I'm an I'm an entrepreneur,
I'm
relationships, I've got friends,
girlfriend, family. How would I show up
differently if I was able to make my
brain big, fat, fluffy?
Yeah. So, uh let me start with the two
areas that we know respond really,
really well to things like meditation
and exercise. Those two brain areas are
the hippocampus, critical for long-term
memory, your ability to form and retain
new long-term memories and for facts and
events. And the second brain area is
your prefrontal cortex, right behind
your forehead, critical for your ability
to shift and focus attention. Um it's
important for your personality, for
decision-making.
Can you show me on there? Is it you
brought
Absolutely. I brought a human brain.
You You have
that.
a model of a brain as well.
a model of the brain. Okay, let's start
with the model of the brain.
So, here is a model of the human brain.
So, there's a front part and a back
part. This front part is right behind
our forehead. That's the prefrontal
cortex, critical for the ability to
shift and focus attention. Also, a part
of the brain that is very responsive to
what you bring into your life. Exercise
actually really helps the prefrontal
cortex. Meditation
helps area 10 of the prefrontal cortex,
which is right in the very front, right
here. The second brain area that you
will benefit from when you make your
brain big and fat and fluffy is a
structure called the hippocampus, which
is which is very deep in this lobe,
deep in this lobe right here, which is
the temporal lobe. The hippocampus
Hippocampus means seahorse, and the
hippocampus is critical for your ability
to to form and retain new long-term
memories for facts and events. You have
one on the right and you have one on the
left. So, for you,
superstar podcaster, what do you need to
do? You need to remember all the details
of that guest that you're sitting in
front of. You need to be able to focus.
What did they say? What do I want to ask
next? And how do I want to come back to
those things? That is a combination of
what your prefrontal cortex is doing for
you and your hippocampus is doing for
you. So, I submit that you, when you do
these things that we know from
neuroscience, are going to make your
prefrontal cortex and your hippocampus
big and fat and fluffy, you will be
better at doing your job as a podcaster.
I am better as a dean and a professor of
neuroscience and and teaching in class,
for example, is where I'm using my
prefrontal cortex and my hippocampus the
most. Most of us would benefit from
these things that make our brains big
and fat and fluffy.
Was there a point in your life where you
had a personal epiphany or revelation
about the brain that made you so
passionate about the subject?
Absolutely. Absolutely. So, this story
starts when I was in the middle of
getting tenure um at New York
University. So, it takes six years. Uh
you have six years to prove yourself as
a scientist and do something
groundbreaking. And if you don't, you're
fired. So, no big deal. No pressure
there. And I decided to only just work.
Work, work, work. I didn't have a lot of
social interactions. I was just working
and I just just threw myself into work.
And I was getting burnt out. And
I decided to go on a river rafting trip
to Peru
by myself cuz I had no friends. So I go
on the river rafting trip and it's
great. It's beautiful. We're river
rafting. We're we're camping on Aztec
burial sites and it is just spectacular.
But I realized that I'm the weakest
person on this trip. And when I got back
after this wonderful, you know, two
weeks in Peru,
I said I never want to feel like the
weakest person on a trip like that
again. And it was so great to to be
moving and to be exercising. So I
decided I'm going to go to the gym and
I'm going to continue this
physical activity at the gym. And
somehow it stuck. I had I had let myself
go, not no exercise at all. And when I
started going to the gym regularly, I
noticed that that great mood that I
found in Peru every day during the river
rafting trip stayed with me. I think
everybody in my lab loved it when I was
going to the gym. And I started to
notice not only I got stronger, I was
feeling better,
that mood boost that I got from physical
activity was so powerful. But then one
day this you asked me about this
revelation I had. It was one day I was
sitting in my office
writing a grant,
which is usually something that I have
to do very regularly, but usually
something that I'm pulling my hair out.
It's so hard. It's very competitive. I'm
competing against Nobel laureates for
the same pot of money.
And I had this thought that went through
my mind, which was
gosh, writing
went well today. I I'd never had that
thought before ever in my I had been
there for five years at at NYU writing
grants. And so um, I um, I thought, "Oh,
maybe maybe I'm just having a good day.
I'm feeling good."
But I realized that the um,
the writing seemed to have been getting
a little bit better over time. I had
noticed it a little bit if I think about
it. And the only thing I had changed in
my life was regular physical activity
inspired by that trip to Peru.
And so, I'm a neuroscientist. I went to
the literature and I asked, "Well, what
do we know right now about what exactly
exercise is doing?"
And it showed at that moment in time,
about 10 15 years ago,
that exercise can improve your mood,
exercise actually makes your memory work
better, and exercise improves the
function of your prefrontal cortex. And
I thought, "Wow, that that is amazing."
But the last part of the story was that
when all of this was going on, this was
after this day of realizing, "Gosh,
something's you know, my writing is
better and um, maybe it's exercise." Um,
I got a call from my mom who said that
my father wasn't feeling well and that
he had gotten lost driving back from the
coffee shop that he drove to every day,
every afternoon for the last 20 years.
And the hippocampus, that structure
critical for memory, is particularly
important for spatial memory. And as an
expert in the hippocampus, as I am, I
knew that that was a telltale sign of
dementia and maybe Alzheimer's dementia.
But as I talked to my father and of
course we went and got him uh, neurology
appointment, I saw that everything that
seemed to be improving in me, that is
memory, focus,
completely and very very suddenly uh,
diminished in him. His memory was
terrible. He couldn't focus. He was also
very depressed because he could notice
how poor his memory was.
And I think those things together, what
I was noticing in myself about the
physical effects of the effects of
physical activity on my own brain
function, and seeing my father go
through which what was a really
precipitous loss of his cognitive
functions, that turned out to be
Alzheimer's dementia.
Made me think that the power of physical
activity needed to be explored more
deeply.
And by me. I I was waking up in the
morning thinking about what can we what
can I do to better understand how
physical activity could be used not just
for me, for my students? Can they study
better? Can they learn better? Can it
help maybe not my father, I wasn't sure
whether exercise could help my father at
that point, but as people age, that was
the revelation that I had that made me
actually switch my research focus from
memory function to understanding the
effects of physical activity on the
brain.
All of this is rooted in a
fact that was once not considered a
fact, which is the idea that our brains
can change shape.
Yes. Yeah.
Which is this idea of brain plasticity.
I mean, I really learned about this a
couple of years ago cuz I think I, like
many people, didn't realize that like
muscles, my brain changes shape based on
what I do.
Yes.
And also what I consume.
Yes.
I guess.
Yes.
What is the evidence for the studies
that we have that proves our brains do
change shape?
Yeah, that's such a great question and
uh it takes me back to the first day of
my freshman year at UC Berkeley. When I
walked into the classroom, I didn't know
at the time, but the classroom of the
professor that discovered brain
plasticity. Her name is Marian Diamond
and she was the very first female PhD in
neuroanatomy that UC Berkeley ever gave.
Um I walked into her classroom in the
'80s when I went to college, but she
discovered this in the late 1960s.
Um, when it was thought, as you said,
that the adult brain can't change at
all. There's absolutely no evidence for
it. And that was true at the time. She
thought, "Hmm, I don't think that's
true. Let's Let's do a simple
experiment. Let's try and um
uh look at the effects in two randomly
grouped set of rats. One that lives in
what they would consider an enriched
environment. What would be an enriched
environment? Well, for her, it was a rat
cage full of toys that got changed out
all the time, lots of other rats to play
with, and um lots of lots of activity. I
think of it as the Disney World of rat
cages. And she compared the brains of
those rats to rats that she raised in
kind of a shoebox, a smaller
environment. They got free food and
water, all the food and water they could
eat and drink, but maybe only one other
rat and no toys.
Now, if the adult brain They were all
the same age, they were adults. If the
If the adult brain didn't change, then
there should be absolutely no difference
between the brains raised in Disney
World and the brains raised in the
shoebox. But she found that the
the brains of those rats raised in the
Disney World of rat cages, the outer
covering of the brain, the outside of
the brain here, I'm pointing to the
outside of this brain model here, called
the cortex, it was actually thicker. She
was She was a neuroanatomist, and she
showed that the thickness of this outer
covering actually grew. What does that
mean? There were more synaptic
connections there. In Not in the whole
brain, in certain brain areas. That made
sense. The visual cortical area. There
was much more visual stimulation in the
Disney World of rat cages. The motor
areas were thicker. The somatosensory,
the touch areas were thicker because
they were interacting in a much more
complex way with their touch system.
And that was the first demonstration the
adult brain could change, and that it
would actually make the cortex of the
brain grow.
And now we know, what is it about the
Disney world of rat cages, you know? Um,
is it the toys? Should we all be playing
with toys? Later studies showed that you
get almost identical effects just by
giving rats a running wheel.
Physical activity is doing all of that,
has the potential to change all of that
in the rodent brain, and now in the
human brain.
Didn't they find something similar with
um, London taxi drivers? I always hear
this. I I thought it was like a wasn't
sure if it was true or like a rumor, but
no. It's absolutely true. That is a
different form of brain plasticity,
which is something that we all do, and
my students do hopefully very well,
which is learning.
So, can learning the streets of London,
which are I can't remember the the the
number of different streets that London
taxicab drivers have to learn to pass
the famous test called the knowledge,
but I do remember that it takes them 4
years to study for this test. It is
intense
uh knowledge. You have to learn all the
lawful ways to get from all the big
landmarks to be a certified London
taxicab driver. And what uh my colleague
Eleanor Maguire, uh professor of
neuroscience at University College
London, did is she followed wanna-be
London taxicab drivers during their 4
years of the knowledge, this test for
London taxicab drivers, knowing that
half of them were going to fail. They're
they're they were not going to make it.
And so, she tested them at the beginning
and asked, "How is your memory?" Uh, and
how big is your hippocampus?
Identical for all all of the wannabe
London taxi cab drivers before they
started.
She scanned their brains.
Yeah, she scanned their brains and she
tested their memory.
Okay.
Behaviorally.
Then they go through, half of them drop
out, they don't become London taxi cab
drivers and half of them become
certified London taxi cab drivers after
successfully learning all of this. Now
let's see, how big is your hippocampus
and how good is your memory? The people
that passed the test and became London
taxi cab drivers, the posterior part of
their hippocampus, which is the part we
know is important for it with posterior
is back towards the back of the head,
the posterior part of the hippocampus,
which is kind of a cigar-shaped
structure that goes from the front part
of the brain to the back part of the
brain, that back part of the brain was
significantly bigger in those London
successful London taxi cab drivers
compared to the failed London taxi cab
drivers. And the memory of the
successful London taxi cab drivers were
now superior to the memory of the
wannabe London taxi cab drivers that
failed. So that is an example of how
intense learning in a particular part of
the brain,
we know the posterior hippocampus is
absolutely involved in spatial learning,
that can change the actual structure and
the function.
How much of a difference can we make?
I'm 31 years old now.
Yeah.
So if I got serious about my brain
health,
Yeah.
how much of a difference can I
realistically see?
You know, I'm trying to figure out if
it's worth it.
Yeah.
If it's worth caring about my brain.
Mhm.
Is Is there any evidence within the
literature, within studies that have
been done that show if I start now, even
though I'm like 30 31 years old,
my life will be different in the future
in the areas that I care about
profoundly if I start caring about my
brain.
Let me be very very um
um concrete here. The answer is
absolutely yes. First, I'm going to give
you results of a study in people that
are 65 and older. So, study people that
are 65 and older
and asked, "What is the probability of
getting dementia in the next 6 years
depending on the level of activity that
you have just right now?"
Physical activity.
And they measured it in how many walks
you take per week.
And if you took three walks a week or
more,
you were 30% less likely to develop
dementia in the next 5 years.
So, ooh, 30%
uh less likely to develop dementia. My
father passed away of Alzheimer's
dementia. That makes me sit up and take
notice. But the But the thing that
should make you as a 31-year-old uh
really sit up and take notice is the
larger correlations that show that the
longer you have regular physical
activity in your life, the longer you're
able to stave off dementia. The more
active you are over your lifetime, um
that first study shows that it's never
too late to start. You can start walking
regularly, which is doable when you're
uh perhaps at that age. But the longer
you stay active, the bigger and fatter
and fluffier your brain will be. Why
does that make sense? So,
one key piece of information that I
haven't told you yet
is that we know that physical activity
is releasing a whole Every single time
you move your body, you're releasing a
whole bunch of neurochemicals in your
brain. Some of them make you just feel
good. Serotonin, dopamine,
noradrenaline, endorphins. Yeah, I feel
good. If I go out for a walk, I feel
better than if I had been sitting here
for 8 hours. But, the other thing that
gets released every single time is
growth factors. I like to call it a
bubble bath of neurochemicals that
happens every time you move your body.
What that
growth factor does is it goes directly
into your hippocampus, and it helps
brand new cells grow in your
hippocampus. The hippocampus is only one
of two total brain areas where new cells
can grow. That's not the same as
synapses, which are connections in the
cells that are already there. But, the
hippocampus can grow new cells, and this
is really important because many people
know that the hippocampus is attacked
first in Alzheimer's dementia.
And so, exercise is not going to
eliminate that disease state, but if you
start with a huge, fluffy hippocampus,
it's going to take that disease that
much longer to actually damage enough of
your hippocampus so that you start
seeing those telltale signs of memory
impairment that comes with Alzheimer's
disease and and dementia in general.
Same thing with the prefrontal cortex.
Your prefrontal cortex can grow with
physical activity. That's not neurons,
but new synapses can grow.
Age and neurodegenerative disease states
can damage cells, but also take away
synapses.
I got two questions on that. So, the
first is about dementia and Alzheimer's.
Do we know what's causing it?
No.
We still don't know.
No.
And there's not
good drugs, unfortunately, right now.
There's a lot of links to lifestyle
choices there, right?
Yes, absolutely.
And so, of course, from based on what I
just said, my number one most powerful
tool that you can do to protect your
brain from aging and neurodegenerative
disease states is start walking.
Why do I start with that? Because
everybody can walk. You don't need to
buy any new fitness outfits. Just go out
and walk more. And then they say, "Oh,
well, do I have to become a marathon
runner?" That could help, too.
But everybody can walk. And from that
study that I mentioned in the
65-year-old, si- 30% reduction in um the
probability of getting Alzheimer's with
just walking.
You said that if I go and start walking
and I do exercise, my prefrontal cortex
will grow.
Which is the decision-making center,
right?
Yes.
So, does that mean then that if I am
somebody who is very sedentary, I don't
do much physical activity,
Mhm.
that my decision-making will be worse
compared to what it could be with the
same person if they were active?
Yes. I mean, that there is that
potential. Brain plasticity and the
neuroscience of brain plasticity tells
us that absolutely with physical
activity, uh you have great potential to
improve the function of your prefrontal
cortex. And I must specify a little bit.
Uh the main function that is um that has
been shown to be particularly sensitive
to regular physical activity is um
shifting and focusing your attention.
So, being able to um listen to me while
you might be paying attention to uh the
AV guy that might be telling you
something right now. So, to be able to
do that effectively, uh that that is one
of the things that we know is helped
with regular physical activity.
Focus and attention, that kind of thing.
Okay. You talked about memory as well.
Does that Does that exist in the
prefrontal cortex as well?
Uh there's a form of memory, working
memory, uh which is kind of scratchpad
memory. It's a memory that um when we
used to have to remember telephone
numbers, that that the ability to
remember a seven-digit, at least in the
United States, telephone number. It's
different from long-term memory
formation, which is memory for facts and
events uh that is dependent on the
hippocampus.
I feel like my memory is not great.
Most people feel that.
Why is my memory not as good as other
people?
Because I I noticed this when I I was
with my friend in um Thailand many years
ago. I think I was 21 years old and we
could like leave the house and go on our
little mopeds for about an hour and he
could navigate us back home without
needing sat nav or Google Maps. And if I
go 3 minutes down the street, I'm lost.
Mhm.
And I always wondered why that was. Is
it because And then even with names and
stuff, I would always He's my best
friend. He's He's one of my best friends
for for 7 8 years. We ran a business
together and he would remember every
name of every person
and I couldn't. I wouldn't. And so I'd
always turn to him and say, "What was
that person's name again? What's that
you know?"
And I always wondered why my memory He
seemed to have this incredible memory
and mine seems to be pretty rudimentary.
I would argue that um yeah, everybody
has parts of their memory that aren't as
good as they want, but also other forms
of memory that they're very good at. So,
I would guess, I've only just met you
today, that your memory for stories and
storytelling and story progress is
excellent because it has to be for the
job that you do. I bet you it's much
better than your friend that can
navigate back. Not everybody has a
perfect memory in all the different
dimensions and and it's like our
personality. Some people have a
wonderful sense of humor and others
don't. Um It is about how our brains are
wired, which is defined both by nature
and nurture, our genes and you know, if
I if I went to uh stand-up comedy class,
I would probably get funnier, but um uh
but there's probably a limit to my
funniness compared to other people.
So, there's different types of memory.
Yes.
In your book, you talk about there being
I think it's like three different types
of memory in total.
That are formed in the hippocampus.
Uh there's lots of different names for
forms of memory in the hippocampus. Um
but I like to describe it as The
hippocampus is critical for our memory
for facts and and events. Um also called
declarative memory or cognitive memory.
Uh another form of memory that's
dependent on a completely different
structure is motor memory, like the
memory that you uh use to learn how to
play tennis or pickleball or whatever
you're playing. And it's not
declarative. I can't declare how I do a
backhand in in in tennis, but it is in
your motor functions. And and this is
dependent on the striatum and a a
motor-related structure. And then
there's the prefrontal cortex dependent
on that working memory or scratchpad
memory, keeping things in mind. So um
you and I are both trying to remember
what we've just said so we can we can
link it to things that we might say in
the future.
Uh uh one of the things I found really
interesting, both as a marketer but also
as a podcaster and as someone that's
making a lot of
content and trying to get people's
attention, was as I was reading through
your work it became quite clear to me
that there's an a bit of an overlap
between memory and attention in in many
respects because you were talking about
these four things that make facts or
events memorable. And many of those
things are things that I think about as
a marketer when I'm trying to get
someone
that make facts or events memorable.
Yes.
And many of those things
are things that I think about as a
marketer when I'm trying to get someone
to, you know, engage with something,
click on something, buy something. What
are those four things?
Okay.
Can we go through them?
Absolutely. So I like to say there are
four things that make memory stick.
And this is after 25 or 30 years
studying the hippocampus and and how
memories work. Number one is obvious
repetition.
Okay.
You you remember things with repetition.
Number two, not as obvious, association.
The hippocampus is an associative
structure. It associates one thing with
the other. Uh for example, your name and
your face. So I'm you know, I've just
met you and I mean I I I will remember
your name and your face now, but it also
helps you remember things like who's
married to each other, associating the
husband with the wife. Uh have you heard
of the memory palace?
Uh yes.
Yes. So, this is a technique that has
been used for many, many
ages uh to help remember things. And it
is a strategy where you picture a
special location
that's very familiar to you, like your
childhood home. And when you need to
remember a list of items, you take an
imaginative walk through that very
familiar environment and place those
items in particular locations in the
environment. That is associating
something really familiar, your
childhood home, you know every corner of
it, with the new thing you need to
remember. And that works uh and has
worked for memory champions for many
years because the hippocampus associates
things together.
That's number two, association. Number
three is novelty. We remember novel
things. I've never been to this
particular studio ever before in my 26
years in New York and Brooklyn. So, this
is a novel thing and I remember I will
remember coming here uh to do this
podcast with you. Our brains, and this
is where it interacts with the attention
system. Our attention system focuses on
things that are novel. Why? Because it
could be dangerous. If I've seen it
things over and over and over again, I
don't notice them. They go into the
background. It's not going to hurt me
any, you know, it's not it's not going
to cause me any danger.
Cliché. That's why cliché doesn't work
in marketing.
Exactly. Yeah. And so, but something
novel, ooh, that really uh perks people
up. I use that in my teaching all the
time. Surprise students uh with uh an
element of what you want them to learn,
and they will remember it better.
But the fourth one, which is so
powerful, and we know it intuitively, we
understand this intuitively, is
emotional resonance makes things more
memorable.
We remember the happiest and the saddest
things in our lives because that
emotional resonance is solidifies those
memories. Where does that come from? It
comes from a structure called the
amygdala that sits right in front of the
hippocampus, right in the front of the
temporal lobe, right here. And the
hippocampus is right behind it. Amygdala
means almond. It's an almond-shaped
structure and it sits right in front of
um the kind of tube-shaped structure
that is the hippocampus behind it. And
the amygdala is kind of infusing uh the
hippocampus and kind of getting a giving
it a little jolt when it's emotionally
resonant, either really happy or really
sad.
You brought with you what you've told me
is a real human brain.
Yes, I did.
Now, I'm not sure if you're just winding
me up, but we're talking here about
novelty and surprise and
That's right.
things you'll never forget and emotional
resonance.
Correct.
And while you're saying that, I was
conscious that over in the corner of the
room it appears that there's a human
brain in a box. So, Jack is just
bringing the human brain in.
Yes.
I've never seen a human brain before.
You've never seen That's why I brought
you gloves so that you can hold it if
you like.
If you like.
Do you have permission
to If there is a human brain in this box
and you're not winding me up, did you
have to get permission from the
owner of that brain?
So, um this was
purchased uh lawfully um by my
department, the Center for Neural
Science at New York University. So, it
is lawfully ours to use as a teaching
tool.
And it does bring enormous novelty to
any situation that I go into and makes
people really think about their brain in
a new way, which is why I bring it.
What is in that box?
In this box is a real preserved human
brain named Betty.
Was the person
who used to own that brain called Betty?
No, we don't know the name of the
person. I named this brain Betty, so
Can you Can you tell if it's a man or a
woman?
No, I can't.
Huh. Man Men and women brains not
different at all?
They are, but in very, very subtle ways
that we wouldn't be able to tell just
looking at the the outside of the brain
like this.
Okay, I'm ready.
Are you ready?
I think so.
Okay. So, I'm going to open
the hat box.
No way is that a real
out
Are you joking? Is that really a brain?
It is
a real preserved human brain.
There it is.
Frontal lobe.
Frontal lobe.
Occipital lobe for vision.
Occipital lobe back there.
And in this brain, I don't know if you
can see it from over there, if I pull
apart
the two hemispheres, you can see how
deep
the the folds of the brain
the surface is folded in that deep into
the brain, which expands the surface
area of the outside of the cortex. The
rat cortex is flat. There's no folds.
Humans and elephants and dolphins have
lots of folds. They have much higher
capacity for computation because of the
folds that you see in this brain.
It's smaller than I was expecting.
Really? Half the people say it's
smaller, half the people say, "Wow,
that's that's enormous."
Interesting. Is that the the color of a
brain?
The color of the brain is darker than
the real brain if we opened up my head
right now, um, because of the
formaldehyde, the the preservative
chemical that this has been sitting in
for at least 26 years. This brain has
been in my department for
ever since I got here 26 years ago.
I feel like I probably should hold it.
I think you should hold it.
Oh my god.
It's wet.
Yes.
So, I mean that that has that defined
this person's whole life.
How they saw, felt, smelled,
heard, and thought about the world.
Just right there in your one hand, in
your right hand.
It's crazy to think that this little
thing is Oh, it's different underneath.
Yes.
It's crazy to think that this little
thing this little
That's the start of the spinal cord
right there that you're pointing at.
And this stuff at the underneath at the
back this
That is the cerebellum.
A brain structure critical for fine
motor movement. Um so, we wouldn't be
able to walk smoothly if you have damage
in your cerebellum.
Isn't it interesting that like
everything, as you say, everything this
person worried about, every thought,
every memory, every relationship,
all of their education, the school they
went to, the university, everything they
saw and remembered, and all of their
trauma,
Yep.
and their
anxiety, and maybe their depression,
everything they went through, even their
last days before they died, is like
captured in this little ball of like
tofu
Yep.
that sits in my hand. An entire human
being's existence.
It's true.
What they watched on TV, their favorite
movie, their favorite number, color,
everything is in this tiny little ball
of tofu.
It's true.
Oh gosh.
It is amazing and actually in real life
firm tofu is the consistency of of the
brain. I often bring in a
you know a block of of firm tofu
when I demo this for students in
addition to Betty.
Do you remember the first time you saw a
human brain?
I do.
Did it change how you think about your
own brain?
It changed my life because I was like I
want to study that. That is the coolest
thing that I've ever seen in my whole
life and I want to study that and I want
to be just like her and um
and so it it really like okay now I I
decided this is what I want to do.
And it was it was
it was life-changing.
I say that because we you know at the
start of this conversation we said that
most of us don't appreciate our brain. A
lot of people don't even realize it's
there.
Yeah.
The minute I had a brain scan one day
and that brain scan
really changed my life because seeing my
own brain for the first time
Yeah.
it was the push that I needed to start
caring more about how my decisions and
behaviors are impacting it. So let's
talk about how I can make that ball of
tofu in my head super healthy
Yeah.
Right.
You talked about exercise earlier on but
we didn't really dig dig into exactly
what you mean by exercise cuz exercise I
think is multifaceted in its definition.
What kind of exercise should I be doing
to make my ball of tofu in my head
great
Yeah.
optimal.
Mhm. Well, all the research shows that
the best kind of exercise that you can
do is anything that gives you aerobic
activity that is getting your heart rate
up. So that that goes for you know power
walking will get your heart rate up
soccer so many different things name
your activity. So many people want to
say oh
my favorite activity, will that work?"
And I always just say, "Is it Is your
heart rate up when you're doing it?" If
the answer is yes, then yeah, that that
works great. We know that that level of
aerobic activity is critical cuz that's
going to release that growth factor
maximally to get into your hippocampus
that will grow those new brain cells.
How much?
So, um I have an answer to that. So, um
we did two different experiments in my
lab. One in um low-fit people, people
that are really not exercising very much
at all, less than 30 minutes um
um in the last three three weeks you
you've moved your body. And um we asked
what could we see any behavioral
improvement in your memory function from
your hippocampus or your uh ability to
shift and focus attention if we ask you
to move your body in aerobic way for two
to three times a week. And we
collaborated with a spin class, so
clearly very aerobic. And what we found
was
in those people that did successfully do
two to three times a week of 45-minute
aerobic activity,
their mood got significantly better,
their memory function got better, and
their ability to shift and focus
attention got significantly better. So,
that gives a little bit of a guideline
for low-fit people, two to three times a
week can start to give you some of those
some of those cognitive changes. But,
you don't look low-fit. So, let me let
me answer the question you're about to
ask me. You're like, "What about me? I I
exercise pretty regularly." And um how
much how much do I need? So, to answer
that question, we went to another spin
studio, and we said, "Look, we're going
to give you free classes. You could
exercise as much as you want in this in
this um
at this studio, and uh um go up to seven
times a week." And the control was just
stay the same. You know, you they were
they were working out twice a week at at
the studio.
Control was the other group that were
you testing them against?
Yes, exactly.
And so what we found was
basically every drop of sweat counted.
The more you exercise, the more change
in your brain we noted. Both your
hippocampal function, prefrontal cortex
function, and mood.
If you you you were already getting
benefit, you know, you're already going
twice a week. But the more you did, the
more brain changes you got. So, that
that doesn't give the formula that I
would like, but we were heading in that
direction, which is part of one of the
questions that I want to answer. But I
love to leave people with the idea that
every drop of sweat counts for building
your brain into the big fat fluffy brain
that you really want.
And then in the real world,
again making it super um
real for people.
Yeah.
How how does that change how I show up?
Yeah.
If you allow it to, should have a
beautiful effect on your mindset.
Um that your mindset around um
how often should I take wake up
30 minutes early and do that walk before
I start my day or accept the the
invitation to go walk the dog with with
a neighbor. It's not an obligation. It
is something that you're doing for
yourself. It is going to have direct
benefits on that ball of tofu as you
call it in your head. It's going to make
it work better. And and I mean, I think
the most immediate thing that I benefit
from every single day is the mood boost
that you get from that serotonin,
dopamine, norepinephrine that gets
released every time you move your body.
I always think that cuz obviously I do a
little podcasting and it's I'm super
reliant on my brain being attached to my
mouth and sometimes I notice that it's
not. You know what I mean? Like
sometimes I'm not articulate, I can't
get my thoughts together, whatever.
Yes. And I always try I've tried to
figure out the correlation between what
I did that day when I have a good day
versus a bad day. And I've from from
your And also I speak on stage
sometimes, so I've often asked myself
cuz I saw Tony Robbins, the speaker, one
day on a trampoline before he goes up on
stage. I asked myself, okay, should I be
doing a workout in my green room before
I go up on stage for a big talk or
presentation?
You think I should?
Oh yeah, absolutely.
What's the basis of that in science and
neuroscience?
Uh it's the basis is that immediate So
there's three key effects that we know
happen every time you move your body.
First one is mood, you're going to get
your dopamine, your serotonin up. Um
second is focus and attention. So So a
single workout isn't going to make more
synapses in your prefrontal cortex, but
the prefrontal cortex uses dopamine. And
so um it's clear that even a single
workout can make your prefrontal cortex
work better in terms of focus,
attention. Also very important anytime
you're speaking. And the third is
reaction time. Your reaction time it you
know, motor your your your working your
motor cortex when you move your body and
your response and reaction time is
significantly shorter after a even a
single workout compared to if you just
don't work out and sit sit um alone. So
great great things to do. A great thing
to do before you you stand up and speak.
What about
coffee?
I I I'm trying to figure out if coffee
is good for my brain, bad for my brain.
I've had a couple of mixed messages
around
the impact it might be having.
Yeah.
You know, caffeine is a stimulant and uh
people respond to that kind of stimulant
uh in different ways. Overstimulation
with caffeine is is not good for your
your ability to put words together. You
know, this is where I turn to uh
a main theme in in my book Healthy Brain
Happy Life with this which is
self-experimentation.
For you, how what can you titrate your
coffee to see what level of coffee is
best for whatever your podcast or you're
giving a talk. The other thing that can
work similarly to coffee that that I've
started and that I do every morning is
hot cold contrast showers because that
cold that you
shower on yourself after the heat
stimulates adrenaline in you. A natural
adrenaline.
It wakes you up and okay, it was painful
the first kind of few times I tried it,
but then you get addicted to it and I
have forgotten to do it and gotten back
in the shower just to douse myself with
cold water because I feel better when I
do that for for you know, first thing in
the morning. So, lots of different
things that one can explore with.
Okay, on the other side of the coin
then, what are some of the central
behaviors that people do that destroy
their brain?
Well, sedentary behavior is one of them.
Um, not getting enough sleep
is critical. We haven't talked about
sleep yet. Sleep is so important for
normal functioning of the brain. I like
to scare my students by saying that um,
you know, in torture situations, if you
deprive a person of sleep for too long,
they literally die. They they they die.
You cannot function if you are deprived
of sleep for too many hours in a row.
It's that critical. Yet, we don't we we
happily you know, watch too much Netflix
at night and and and and get only 5
hours of sleep when we could have had
eight. So, what's happening exactly? Why
is it so important? Well, there's
there's so many different things. I'm
going to I'm going to say two. One is
that we know that in regular
um healthy sleep there is activity in
the hippocampus that helps you
strengthen the memories that you have
formed in that previous day. It's called
consolidation and it's so important. If
you shorten that, if you don't get
enough, you are not consolidating your
normal everyday memories. And second, it
is the time during sleep when all the
metabolites, all that garbage that your
brain is producing because all
biological cells produce garbage, it
gets kind of cleaned up through the
cerebral spinal fluid that that is
flowing through your brain. And if you
do not get enough sleep, you build up
garbage metabolites in your brain. It's
like you have a gunky brain. And do you
feel like I feel like I have gunk in my
brain when I don't sleep enough. That is
exactly what is what is happening.
Well, when you think about things that
we consume, you know, like food and
drink and alcohol and all these kinds of
things. Is there is there anything that
if I'm trying to have an optimal brain,
I should be
Yeah.
having or not having?
Yeah. Well, so um
I think the most evidence is around the
benefit of the Mediterranean diet, which
is basically all healthy
kind of organ not organic, but
non-processed is the word I was trying
to think of things to eat that are very,
very colorful.
There is so much evidence about how good
that is generally for the brain. That
that is my go-to. Like what what should
I eat? Well, is it on the Mediterranean
diet? If it is, then go ahead. If it's
too processed,
only do it. Just a little bit.
Is it true that if we have less friends,
if we have less strong relationships, if
we're lonely, then our brain will shrink
and is more prone to dementia and
Alzheimer's and things like that.
Yes, we are social creatures and um
there are uh really powerful studies
that have shown the correlation between
the number of social connections that we
have, including just saying hello to the
barista at Starbucks. It's not a close
friendship that you develop over 30
years. It's It's just how many people
you interact with and greet and
longevity. The more people you are
regularly interacting with, the longer
you are living. Overall longevity. But
if you go into brain health, absolutely
it's also very very healthy for you. It
also brings happiness. So uh friend and
colleague of mine um Robert Waldinger uh
studied um what makes people happy. The
study started in the '20s, the 1920s at
in in Harvard. And after all of those
many many many decades, the answer is
what brings happiness is the strength of
your social connections. So, it makes
you happier, it makes you live longer,
and and uh yes, loneliness on the on the
um flip side
causes stress, uh long-term stress that
that damages the brain and uh yeah, in
the long term can can make it smaller
and uh less healthy.
Do you have any brain routines? Like any
like a morning routine for your brain?
Absolutely. So, every morning I like to
wake up and I do a um
tea meditation, which is a meditation
over the brewing and drinking of tea.
And this is after many years of yo-yo
meditating. I knew meditation was good,
but I just couldn't really get into it
and um
I was introduced to this form of
meditation um from uh by a monk who who
invited me to tea and and just did this
silent meditation outside in a beautiful
location. And the ritual and the um
um the sequence of brewing, drinking,
seeping,
re- starting over again kind of kept me
in kept me in the flow. And so I start
with about a 45-minute tea meditation.
Then I do about a 30-minute workout. I
try and do cardio strength. Sometimes I
do yoga. Sometimes I just do mobility.
And then I have breakfast and then I go
to work.
Oh, and then I I do that heart hot cold
contrast shower is also something very
helpful for my brain health because it
it really does in me that adrenaline
boost that I get just energizes me and I
love that feeling at the beginning of
the day.
Just going back to that question cuz I
want to close off on it as well. The the
idea of what would I have to do to
destroy my brain. So, no sleep.
Yeah.
I'm going to be sedentary.
Yeah.
I'm going to have no friends.
Yeah.
And smoking?
Smoking is very bad for your health and
and your brain.
Okay.
Alcohol?
Alcohol, I mean, yes, long-term alcohol
can cause significant and named brain
diseases.
Moderation even moderation now as
studies have shown it is not very good.
And the reason why it's not good is that
alcohol disrupts your sleep. Even though
people drink it to to go to sleep
faster, the sleep is much more
superficial and is not deep and it's not
the healthy sleep. So, that is not good
overall for your for the for sleep depth
and and health and therefore brain
health.
I'm going to eat a processed diet to
hurt my brain.
And I'm not going to have a lifestyle
that is
novel. Because we talked about learning.
Right.
Yes.
not going to learn anything new.
All of these things should shrink that
little
You're not going to be mindful also.
Does mind Is that Is that evidence that
being mindful, which is like meditation
and being in the moment helps the brain.
It does. There's beautiful studies
showing brain plasticity
in the areas that are important for
focused attention. Meditation, the
practice of meditation is basically a
practice of
enriching the function of your
prefrontal cortex. So you can focus on
that object, either the breath or or
loving kindness is is a form of
meditation. So yes, there there's been
studies that brain changes occur in
long-term meditators that are that are
absolutely beneficial.
What if I'm on social media all the
time?
Because isn't that good for me because
I'm going to be seeing lots of new
things all the time and I'll be learning
lots of new things. So isn't if I sat on
a on a screen for 7 hours a day
is that good for my brain, social media?
Does that take you away from real people
and interacting with real people?
Yes.
Okay. Then then it's modulated by that.
There
the same thing?
There's a difference and I think your
brain knows it and
look, there's there's enormous amounts
of evidence showing that the increase in
use of social media
especially in young kids correlate with
huge increases in depression and anxiety
levels particularly in young girls. So
when
when kids started getting the
smartphones and started to spend more
and more 7 hours a day on social media,
that's when the anxiety and depression
went up. That's for young kids. I use
social media as well as a tool for
business. That is a little bit
different. I'm not 13 years old and
you're not 13 years old. So so you know,
there there's some warnings I think that
need to go into into that. But but let
me let me be clear. No, it's not the
same. Social media is not the same as
social interaction face-to-face with
people.
Are Are are you concerned about what
social media is doing to our brains?
Yes.
Cuz you know we I hear we hear those
stats around, you know, young young
girls are struggling most with social
media and we think to ourselves, well,
that's because there's a lot of like
comparison and all these kinds of things
and there's a lot of like toxic
messaging and such, but
if we think about the physiological
consequences of social media, what it's
actually doing to our brains at a
chemical level.
Yeah.
What what would you as a neuroscientist
guess is like is the physiological harm
to the brain? Not the sort of psycholo-
I'm thinking about like not the
psychological like, okay, oh my god,
she's more this than me, but like the
physiological harm.
But the psychological harm causes
stress. Stress releases stress hormone
that goes into the brain that at too
high and too constant a level can start
to first damage connections and then
kill cells. So it's it's intertwined
um there and that that is part of of
what is happening. Um you can't, you
know, pull one
one away from the other.
Cuz you know, we're social media is
designed to kind of It's like pulling
the slot machine handle. I pull down on
the feed and I get ping, oh look,
there's a nice picture and oh ping,
there's notifications and comments, etc.
It's that con- You know, I think about
the constant
They they say there's constant dopamine
hit.
Yeah.
to it. Is it a dopamine hit? Is that's
what's happening when we're being
stimulated by social media or a slot
machine?
Yes.
And is there Is there any harm in just a
constant dopamine hit all day every day?
Well, I would not I'm going to answer
that question by saying I would not want
to be addicted to gambling.
That gambling is addictive. It It's hard
to get away. You You You lose all these
other things that we just decided were
all good for you, including sleep,
including social connections, um
including exercise, and I think that's
part of what social media is doing for
our young kids is not good that they're
not
joining teams outside to be social and
interactive in uh in that
kind of now it seems like an
old-fashioned way, but it's very very
powerful way for development um and
brain health.
I think I'm addicted to my phone.
Mhm.
And I I often ask myself, is that is
that a problem? And from what you've
said, it sounds like the problem is what
I sacrifice
Yeah.
through that like addiction to that
device.
Yes.
Is that that the issue? The issue is I
sacrifice social connections, maybe
movement.
Yeah.
You know. Although I do work out every
day.
But the brain is smart enough to know
that there's no substitute for real
human connections.
Absolutely.
Absolutely.
And that's going to make me what? I'm
trying to I I need you to help me
Yeah.
scare me out of this
phone addiction that I think I have, but
I know many other people have as well.
So, that is going to limit your
potential for brain growth for for brain
plasticity. It is going to limit your
possibility for for, you know,
not to be dramatic, but joy in in your
life. There's different kinds of joy
that you have in in real
person-to-person social interactions
that it feels pretty good on social
media if you get lots of likes and, you
know, um but it's not the same. And um
I would I would say that to scare
yourself out you're going to have to
bite the bullet and do a 2-week phone
detox.
What would that do to you? How would you
feel?
I just could never imagine such a thing.
Well.
Which is a real shame, isn't it, really?
Cuz I just think about like my ancestors
and my parents, they must
they must think I'm so strange, but it's
just the just the way that like when my
phone dies, I'm like there's like
I'm like nervously waiting for it to
come back on. I'm like staring at it
like, "Oh my god, like Like, am I going
to do with myself?" Like,
uh
and I remember those studies they did on
people where they gave them the choice
of either sitting alone with their own
thoughts or giving themselves an
electric shock, and a huge amount of
people in that study actually would
rather give themselves an electric shock
than just sit alone with their thoughts
because it's some kind of stimulation.
That's kind of how I think I am now.
Like, I don't know what I'd do without
my phone. It's really sad. I know
there's people listening to me now that
think I'm an absolute like I'm really
sad, but it's just the naked It's the
truth, you know? And
um I do wonder what it's doing to my
brain, but I think you're right. I think
it's actually what it's doing to my like
my life.
Yeah.
The joy, the connections, the
being being there to experience things,
and um
I mean, that point that you made is a
very profound one.
Um the the not wanting to be alone with
your thoughts
is the core of meditation. Can you be
alone with your thoughts and focus on
something
something organic, usually the breath,
but also a thought like loving kindness.
Um that is a very powerful practice to
do, and it and it's hard. I find it
hard, too. Um
and I actually I notice I find it harder
when I'm
when I'm using social media and when I'm
using my phone more. Um
but I feel most creative
and most imaginative when I do practice
that. That is, being alone with my
thoughts. What comes into mind? Um how
how does my own imagination work, which
is very much dependent on the
hippocampus as well. It's putting
together all these things in your memory
in new and interesting ways that are
unique for you or unique for me. And it
doesn't work the same if you are
stimulating your brain with social media
all the time.
You um I mean, you wrote a book that
kind of speaks to some what we're
talking about here. You wrote a book
about anxiety.
Yes, I did.
In 2021. Yeah, I think the the US
version's called Good Anxiety, isn't it?
Slightly different title in the US in
the UK.
Yeah.
Why did you write a book about anxiety?
I wrote a book about anxiety because I
started to notice my students
getting much more anxious than they ever
used to be.
And this was before the pandemic. I
mean, I I I had the idea to write this
book in
2018, 2019.
And
so first I noticed it in the students.
They were getting so stressed out before
finals. They never did that before. So
so many accommodations they were asking
for.
And I'm like, "What's going on here?"
But then I realized it wasn't just them.
Like I'm getting more anxious as well.
My friends are more anxious. And I
really wanted to dive into that. I
didn't want to be anxious in that way.
Uh cuz part of me was like, "Oh, I'm
just a New Yorker. I'm I'm just anxious
all the time, right?" Cuz that's what
New Yorkers are. No,
this has changed. And we forget that
before the pandemic, there was there was
still global warming warming. There was
still political issues that that lots of
people, including me and all of my
students, were worried about.
And that was the impetus for for trying
to dive in and ask, "Well,
I made my life happier with exercise.
What What is the approach when it's
anxiety? And not clinical anxiety. I did
not have clinical anxiety. And the vast
majority of my students didn't have
clinical anxiety. They had what I called
everyday anxiety. Just worried about the
things that are going on in the world.
And there were just more things to be
worried about."
Is that normal? Is that human?
That is human, absolutely.
But is it human in the
in is the quantity in which we
experience it human?
Uh I think it is. I mean
Cuz I think about my ancestors. I go,
they they probably I don't know. I
always imagine my ancestors kind of I
don't know, just chilling.
Do you know like I've got
But they didn't have they didn't have
global warming where the ocean is about
to, you know, get sucked up in plastic
and and the the ozone is going to come
come down. No worries like that at all.
But but the everyday anxiety for me is
like emails.
And WhatsApp.
Well, by everyday anxiety I mean the
anxiety that people are feeling today
that is not at the clinical level. So,
all the things that we just men-
mentioned, global warming and wars in
multiple places in the world, all of
that contributes to the higher level of
anxiety. And your ancestors and mine
went through two world wars.
But and that was anxiety provoking, no
question about it. But they weren't also
all the other things that were um
you know, contributing to it including
the higher than, you know, extremely
high anxiety and suicide levels of our
young people
that are, you know, that strongly linked
to social media. So, that's that's
another element.
What did you find then when you started
uncovering and trying to go on this
search of figuring out, you know, the
the nature of anxiety and what we can do
about it? Did you first find that your
writing your hypothesis that it is
increasing?
Yeah.
Yeah, that was
Do you know how much?
Um you know, it it shifted over the time
that I wrote and published the book
because I started in 2018 and then it
was published in the middle of the
pandemic in 2021 where anxiety levels
went up approximately 20%
worldwide.
So, um
but the social media anxiety, um that is
going up in girls even more than 20%. Um
that's kind of in parallel. So, I I I
actually don't know how to um integrate
those two levels, but they're both going
in the same direction.
Why are women, young women, becoming
more anxious and suicidality amongst
that age group is
rapidly increased.
You know, I think that um it's it's that
comparison that that is so easy to do
and I see it in my own work at the
university that
when I was going to college, I had no
idea what rank I was in in number in the
application, but they could see that
immediately. They know exactly what
number they are in each and every class
they take in their whole high school
class in the in their application to to
the five schools that they applied to or
10 or 15 now that they're applying to.
That gives a much higher level of stress
when you know those numbers immediately.
Um that we never had. So so there are
stresses like that that that um they're
they're experiencing.
More information.
Yeah.
More
It's funny cuz more social connection,
but it's I want to say social
connection, I don't mean real world
social connection. I mean more followers
and likes and
Yes.
that can message me and tell me
something and DM me or comment on my
thing.
Right.
More noise.
Yeah.
The volume has increased, which is seems
to be driving more anxiety. Where do we
experience anxiety? Where from a
physiological standpoint, where is
anxiety? Cuz it feels like it's in your
chest.
Yeah.
So anxiety is kind of a full body
experience and um anxiety is um
strongly linked with the stress
response. So um an anxiety-provoking
situation, you you um
meet somebody that you uh you know, had
a big fight with before. Oh, I'm
anxious. I might have to speak to that
person before. Uh that
launches that launches the stress
response
um that is um dependent on what's called
the sympathetic nervous system. And so
this is where it becomes full body. So
what happens when your fight or flight
system is activated? Your heart rate
goes up. Your respiration goes up. Your
um irises get get bigger so you can see
everything and look out for that that
annoying person that you're worried
about. And blood is shunted from your
digestion and reproduc- reproductive
organs towards your muscles so you can
fight or run away. That's what all of
our ancestors evolved to protect us from
not
not the social media post, but
the lion or the tiger that could come
and attack us. So it made sense for that
kind of stressor or that kind of threat.
Unfortunately, our bodies do the same
exact thing when the nasty DM comes in
from somebody I wasn't sure who it is,
but they're saying something really bad
about something I care about a lot. And
we get this stress response, we get
anxious because of that. And somebody
asked me, "Does that mean our brain is
not very smart?" And the answer is our
our our stress and our threat system is
not very smart. It isn't differentiating
between the lion that could physically
kill us and the DM that might wound our
pride,
but but will not kill us. But it causes
the same kind of
stress response and anxiety response.
What do I do about that?
You have to learn how to turn the volume
of your own anxiety down. And part of
that is I'm not saying you have to not
look at your DMs and not look at or not
look at social social media. There's
lots of ways to turn your anxiety down.
We've already talked about some of those
approaches. Exercise immediately
decreases anxiety and depression levels.
And there, you don't even have to get
aerobic. 10 minutes of walking can
significantly decrease your anxiety and
depression levels. That is a powerful
tool that everybody can use right right
here right now.
Breath meditation. Did you know that
breath meditation, that is deep
breathing,
um
is the oldest form of meditation. Why?
Because equal and opposite to that fight
or flight response that everybody seems
to know about is the rest and digest
part of your nervous system called the
parasympathetic nervous system that
calms you down. It slows your heart rate
down, slows your respiration rate down,
and shuts blood from your muscles
towards your digestion and reproductive
organs so that you can do those weekend
rest and digest kinds of things.
Well,
everybody should be asking, "Well, do I
have that system?" Yes, everybody has
that system. Everybody has a
parasympathetic nervous system. How do I
activate that? The best and most
effective way that you can activate that
right now is take three deep breaths
because that's the only thing you have
conscious control over that can launch
all the rest of that parasympathetic
activity slowing your heart rate. I
can't slow my heart rate by thinking
about it. Can I take three deep, slow
breaths right now? Absolutely. And monks
hundreds, if not thousands, of years ago
realized that. That is the thing that I
can do immediately to slow my slow my
stress response down. It's very, very
powerful.
Sadness.
Sadness.
Sadness is um
can be linked with anxiety and um
you know, sadness like anxiety is
something that people
I think would like to kick out of their
lives and just never have any more
at all. If I could get rid of sadness
and anxiety, I would be the happiest
person alive.
But would you?
Because my argument in good anxiety, my
book Good Anxiety, is that
these prickly emotions, these difficult
emotions, like anxiety, like sadness,
are really, really valuable because
they're they're focusing us on things
that we should be paying attention to.
Specifically, anxiety. It is a warning
system. Oh, there's that person. Oh, you
didn't have a good interaction. You you
need to pay attention. Now, should it
throw you into a an anxiety attack?
Perhaps not. Use some of these
techniques. Um like like deep breathing
and and going for a walk. But it is a
warning system. And
why is this valuable? Here's why it's
valuable. It's valuable because when you
know what
you are worried about, your fears that
your anxiety focuses you on, it actually
tells you about what you hold most dear
in your life. And that is something that
we should all
really want to know. So, if you're a
people pleaser,
um you are doing lots of things to maybe
too many things to please people, but
that means that you care about
personal interaction. And I start with
this one because I'm a people pleaser.
And I realized that people-pleasing
response and the anxiety that it does
evoke is reminding me that what's very
very valuable to me is that interaction
with people. I care about that. That's a
beautiful thing. I value that in my
life, in my personality.
I'm going to let you in on a little
secret. What is in The Diary of a CEO
cup? This cup that sits in front of me
when I interview these people, sometimes
for 3 hours, and sometimes three people
a day. And the answer is this, Huel. I
invested in the company on Dragon's Den,
and since then they've gone from an idea
to the fastest-growing energy drink in
the UK. It is a matcha energy drink, and
it is absolutely delicious. But that's
not why I choose to drink it on this
podcast. The reason I choose to drink it
is because it gives me what I call
all-day energy. I don't get the same
crashes that I used to get with other
energy drinks. If you're in the middle
of a conversation, or you're in the
middle of a talk on stage, or in the
board room, the last thing you want to
do is have a crash. You don't want
jitters, and you need focus. And that is
why they now sponsor this podcast. Not
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you haven't tried it, go down to a
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try it, let me know how you get on.
Do you think we could see love in the
brain? Can you see if someone's in love
in the brain?
If we scan the brain of someone that's
in love when they're interacting with
their partner, could we see that?
Um yes, in fact, they have scanned
people who are in the throws of of uh um
romantic love, and people that are in um
you know, many years into a loving
relationship.
And there are uh lots of reward areas
that get activated when you're scanning
the brain um of somebody that that, you
know, is in the throws of deep romantic
love, that is in the first few weeks.
You can't get enough of the person,
you're with them all the time, you can't
stop thinking about them. A lot of the
reward areas are are activated. Uh a lot
of the social interaction areas,
including the insula, uh a part of the
brain right in the side here, just just
uh
in the uh area near the ear, deep into
the cortex, get gets activated.
Doesn't that mean then that if we don't
fall in love, if we don't have those
feelings,
that that part of our brain might
shrink? Because if, you know, they say
often things like
you you use it or you lose it. They say
neurons that fire together, wire
together. If I'm not in love, if I'm not
if I don't have those social
connections, will the love part of my
brain get smaller?
And would that make it more difficult to
love in the future?
That's a great question. I think that um
that study has not been done, but
absolutely, if uh
uh if you don't use that part of the
brain, um you will not, you know, gain
the function. And so, yeah, not not
using your love part of your brain is is
not a nothing that I would ever
recommend.
Some people, I guess, don't have a
choice. Well,
I guess they have a
choice
in the sense that they can do things.
They have optionality, but
for whatever reason, some people don't
find love. It's just an interesting
observation because in all other parts
of the brain, you have to like
Do you mean romantic love?
Romantic love, yeah.
But but you know, there's all sorts of
different kinds of love. Deep
friendship, um, it's actually what I was
going to say is that, um,
they tried to look at the difference
between romantic love and maternal love
or paternal love. And it turns out that
long-term relationships, like
romantic relationships of marriages that
last for many years, start out, of
course, in this romantic phase. But it
turns into more of a maternal, paternal,
um, pattern
when you go farther and farther along.
That that is a win. That is not
something wrong with your brain. Um, I
think love does evolve over time, and
there's many different kinds of love
beyond the romantic Hollywood
you know, uh, and Disney kind of, uh,
uh, form of love.
So, you can see the honeymoon phase in
the brain.
Yes.
And then you can see the more
mature love, I guess.
Yes.
In the brain. Interesting.
Oh, the I guess the the opposite of love
I guess might be hate, but I think when
another sort of thing that people might
think of is
the opposite of love would be rejection
or heartbreak. And through all of our
lives, we encounter heartbreak in many
forms. We encounter romantic heartbreak,
but also other forms of heartbreak. As I
read through your story, I I I I could
see moments in your story where
you encountered various types of
heartbreak.
Yes. Grief.
Yeah.
You talked about your father passing
away from
Alzheimer's.
Yes. Well, he had a heart attack. He had
Alzheimer's dementia when he passed
away. He he died of a heart attack.
And just 3 months after your dad's
death, your younger brother died of an
unexpected heart attack age 50.
Yes.
And you say in your book Good Anxiety in
chapter 4, you say the death was
unfathomable.
Yeah.
As someone who studied the brain and
therefore has a really strong
understanding of the physiology
of the human mind and has also
written a book about anxiety, so you
have this sort of sort of two-pronged
approach towards understanding feelings
and emotions.
Yeah.
In those moments,
what did you come to understand about
the nature of emotion, the most intense
emotions, and how how they captivate us
and how we can find our path through the
jungle?
Yeah, I like that word that I used. It
was unfathomable.
Um um
both of those losses at at the same
time, it was hard to process. And I
remember the waves of grief that would
come over. It wasn't constant. It was
like it it would it would it would be
like waves. So I I have one and then it
would recede and I felt a little bit
better. But then unexpectedly it would
come come again.
And um
I'd never
thank goodness experienced that before.
And um it was in the middle of writing
the book Good Anxiety and I I put it
aside uh cuz I couldn't write when I was
going through this this terrible grief
and and I had to do something that I'd
never ever had to do and actually was my
biggest fear. Um unnamed biggest fear in
my life was um
to have to give a eulogy. I I
have a fear of
uncontrollable crying in public and I'd
always been afraid of of eulogies and
well, I never had to
give a eulogy and I had to give this
eulogy for my for my brother.
Um, another unfathomable how could that
be happening?
And um,
I I got I got through that and um,
I learned something in the process and I
remember
working out to try and make myself feel
feel better during this time and um, the
instructor said
about the workout with great pain
comes great wisdom.
And I just glommed on to that
that message
cuz I was feeling great pain. What was
the wisdom? Like, I need to find some
wisdom. What what is that wisdom?
And I realized
cuz I just say something at this eulogy
that the wisdom was that on the other
side of that unfathomable grief that I
was feeling the only reason why I was
feeling that unfathomable grief is
because of the deep love that I had that
it started with.
So, if I didn't love them as much, I
wouldn't have as deep a grief. So, in
fact
the grief and the the the depth of it
was a sign
of the love that I had for them.
And that
that was the wisdom that I found and
that was the solace that I found and
that was a message that I gave
in
that eulogy.
And um,
and then I became obsessed with
the flip side of these
awful emotions that we all go through.
Grief is this one.
Because I had to go back and finish this
book, Good Anxiety. I was like, "I'm
going to do that."
The book was transformed by that event
because I realized that if I could find
the wisdom and the
the power
um
of the most horrible emotion, I'm going
to say, grief.
What is the flip side of anxiety?
What is the gift? What is the superpower
that comes from anxiety? And I needed to
find gifts and superpowers.
And that's why the book got written in
that way. And I I name superpowers that
come from anxiety. That was That was
heightened after after this terrible
event.
But I found them and I use them all the
time. It was therapeutic, actually.
How did it change you, the loss of your
brother and your father in such a short
period of time? How are you a different
person because of
those two events?
You realize that
everybody's going to
feel these emotions sometime in their
life.
And
I can
bring more empathy and compassion
to those experience for others.
And I I remember I I never wanted to
talk to people
that had a loss. I never knew what to
say. I knew I was going to say something
wrong. I just had no idea. I felt lost.
And um
and it is I do feel wiser. I feel like I
have more
empathy. I have more knowledge.
Can I ask you a question? If If If there
was a pill
Yeah.
that you could take
to
not feel the grief.
In the moment when you were
in the throes of that grief, would you
have taken it? And
in hindsight now,
Mhm.
would you have taken it?
I look I I know.
I'm not a
pill taker. I
I wasn't clinically
I didn't feel like I'm oh, I can't, you
know,
go about my life. It it it it was
it was a terrible emotion, but I I
didn't feel completely debilitated with
it. Other other people do. Maybe they
would take the pill. I would not take
the pill. And after
the lessons that I learned from going
through those emotions, absolutely, I
would not take the pill. And and that
was part of the lesson of writing this
book, that anxiety
is critical for us, because anxiety and
sadness and and anger
are critical
to help us appreciate those joyous
moments if of our lives. If we had no
grief, no sadness, no anger ever,
then every day would, you know, it would
just be mundane. But it gives that
value. I mean, our highest highs are
extra high because we know those lows.
And and that also is probably how this
grief that I experienced affects me. I I
appreciate I appreciate that the good
times even more.
As a neuroscientist who understands the
brain and the systems and then sort of
neural pathways and all this stuff and
how we think and
does that leave much room for
spirituality
and
those kinds of things? Are you
spiritual?
I am.
And what does what You know, cuz when
some people think about spirituality,
they think
it they think it's the opposite of
neuroscience.
They think Yes. If I spoke to some
people, some people that I know, they
think of
that the decisions and the feelings and
the energies are outside of our body,
not going on in this ball of tofu.
Mhm.
And then some like hardcore
people, scientists, will ex- will
explain all of our experience through
this ball of tofu.
Yes.
Where do you sit?
So, um I've evolved over time. So, um
when I was a young scientist,
I no spirituality, no religion,
everything can be described by science.
Like I have to prove it. Prove it to me.
I want to, you know, see the data.
I happily went through um
that phase for many, many years of my
life until I realized or I didn't even
realize.
I think I needed something more in in my
life. And and then I realized
first it was a need. There was a Then
there was a realization, well,
can I really prove that
the only thing that is true is that what
I
what I can prove.
What if there are things beyond
um proving in the
in the scientific method.
And I think there are things that uh in
the spiritual realm, in the religious
realm, um
that
absolutely could be true.
Could be true.
Could be true. That
cannot be solved, cannot be proven with
the classic scientific method.
Things that you believe?
Yes.
What makes you believe them?
Cuz on one hand you said you kind of
want to.
Mhm.
Which is an element of that.
Yeah.
But as a I'm interested as a scientist,
as a neuroscientist,
Yeah.
you must have been trained to be able to
explain. That's how you pass the exams.
You get You must be able to explain why
you have these beliefs.
Do you In that part of your life, do you
just kind of say
I've ex- I felt it. Is that the
No. It's uh Oh, well, part of it, yes. I
I I do feel it. But it was the
realization that the scientific method
in my opinion is not the end-all and
be-all that I thought it was when I was
a young scientist. Can you prove that
these other realms don't exist?
And if they exist in ways that cannot be
proved in in a scientific method, well,
maybe your scientific method is wrong.
Is that Is that a possibility?
Have you had an experience that made you
believe in another realm?
Have I had an experience? Um
I have
in my academic way
I have studied
texts that are
the oldest texts that we know,
uh the Bible, and I was raised in a
actually was a half Christian, half
Buddhist um family. And uh
but
my my
my core belief was
Christianity. And so, yeah, I I I I go
to church. I I really appreciate the
power
um that
that religious beliefs bring
to my life. It actually really decreases
my anxiety.
And that's not the only reason why I did
I just I wasn't look searching for an
anti-anxiety kind of um
uh solution.
But I was
looking for
maybe something more than
the scientific method in my life.
We're going in one direction as a
society, like more Yeah, I told you I'm
basically addicted to my phone. Screens,
loneliness.
Yeah.
Um less connection, less friends, less
people we can turn to in a time of
crisis according to all the studies.
And as we go further and further down
that road, I think it's making it more
obvious of
what's at the end of the other end of
the street.
Yeah.
And it's robbing us of something at a
really deep level that I think I'm
noticing more and more as I grow older.
I think that's actually why I want to
have kids now because I think I'm in
search of that greater meaning or
purpose in my life beyond just like
making more money or just, you know,
all the superficial stuff.
Yeah.
You You said to me before we started
speaking that you're thinking a lot
about community.
I am.
Why?
Because I think it is a balm
to students and to everybody. And um I
think those those events that we can
create that bring people together and
talking to each other and learning about
each other are joyous events. And um I
see it in the in
in me and in uh the students that come
to these events. It is clear that that
is um something that that is a little
bit unfamiliar to students right now,
but um has immediate effect.
What is the one thing we haven't spoke
about regarding
Betty, the brain over there in the
corner, but the brain in front of you.
The most important thing about the brain
that we didn't discuss.
You know,
you only have one.
And um
we have an opportunity every single day
to make it
as healthy as it could be.
I my I watched my father pass away with
Alzheimer's dementia. And um um
we have elderly people in my family as
well. And
it motivates me even more to to keep my
brain healthy,
to make as many friends as I can, to
have as many connections as I can. Uh
cuz I want to be as happy as I can be
for the rest of my life and I want to
have
and I want to have a big fat fluffy
brain.
So you only have one and
there are things you can do right now
today
to make it stronger.
Wendy
Thank you so much. Thank you for
the way that you deliver I think is so
deep rooted in a really undeniable
passion and you you're on a real mission
to make other people live better lives
and I think that's something that
deserves to be
highly commended. It's it's so apparent
in everything you do that you're so
focused on helping others in a way that
I don't always see um
and that comes from like you know
reading through your story I can see the
pivotal moments throughout your story
that sent you on that mission and I do
describe it as a mission. These two
books are fantastic. You wrote the book
in 2000 that we published in 2015 called
Healthy Brain Happy Life and then your
second book which came out in America
called Good Anxiety which is a
phenomenal book that really helps to
refrain how we think about anxiety. I
think that reframing helps us experience
it differently but also shall I say dare
I say
be grateful for the signal the lessons
that it's there to teach us the wisdom
that it gives us.
We have a closing tradition on this
podcast where the last guest leaves a
question for the next guest not knowing
who they're leaving it for.
Mhm.
Question left for you is in this book.
Oh.
What do you think is the best quality of
humanity?
Ooh.
Compassion.
And what does that mean?
Compassion means
feeling
feeling for the
um
um the experience of others both good
and bad. so I can experience your joy
compassionately and I could experience
your grief compassionately. I think that
is because I've been thinking so much
about connection and community
that um
function of uh or emotion of compassion
is uh really top of mind for me.
Wendy, thank you.
Thank you.
Ask follow-up questions or revisit key timestamps.
In this episode, neuroscientist Wendy Suzuki explores the profound impact of our lifestyle choices on brain health. Emphasizing the concept of 'brain plasticity,' she explains that our brain is not fixed but changes shape based on our activities and habits. She outlines how regular aerobic exercise, healthy social interactions, and mindful practices like meditation can physically grow brain structures like the hippocampus and prefrontal cortex, which are essential for memory, focus, and emotional regulation. Wendy also discusses her research on anxiety, reframing it as a valuable warning system rather than just a negative emotion, and offers actionable strategies for maintaining a healthy, resilient brain.
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