The Keto Psychiatrist: What Keto Is Really Doing To Your Body! Can It Cure 43% Of Mental Illness?
2657 segments
most people will experience tremendous
reductions in anxiety within 3 Days To 3
weeks of starting a ketogenic diet in
fact we did a study where patients with
bipolar disorder major depression or
schizophrenia tried the ketogenic diet
and 43% achieved clinical remission from
their chronic mental illness and 64% of
them left un less psychiatric medication
because it improves the balance of
chemicals in the brain but the question
is what's causing those chemical
imbalances in the first place and so
let's start there Dr Georgia e is a
Harvard train psychiatrist who
specializes in nutritional science and
mental health she was one of the first
psychiatrists to offer nutrition-based
approaches as an alternative to
psychiatric medications to optimize
brain function and enhance performance
people need to know how powerful
nutrition strategies can be for the
brain because if you're feeding at the
wrong way things will go wrong and
that's exactly what happened to me my
health was declining in my early 40s in
ways that is true for a lot of my
patients chronic fatigue and IBS being
really anxious and depressed and so I
did all kinds of tests they said there's
nothing wrong of course there was
something wrong so I instinctively
started experimenting with my diet and
the diet that I ended up on was
backwards from what we're told is
healthy for us it should theoretically
kill me but it result every single one
of my symptoms and so I studied for
years learning things about food that
most people don't know and which foods
contain the nutrients the brain needs or
the ingredients that damage the brain
and found three principles of nutrition
they can help you in ways no medicine
can as well as improved mood memory
concentration stamina productivity so
let's unpack that
this has always blown my mind a little
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much
Dr Georg
Eid how do you define what what it is
you
do I am a psychiatrist specializing in
nutritional and metabolic Psychiatry so
how food affects the brain and how food
affects brain metabolism and how brain
metabolism affects our mental health
this is a fairly new phrase metabolic
Psychiatry am I right in thinking that
yes it's a really it's a very new field
and really exciting field uh the the
term itself was coined by Dr Shabani
Sethi who's a metabolic psychiatrist at
Stanford University and maybe five years
ago or so maybe a little longer than
that so it's a very very new field it's
even newer than the other exciting New
Field in Psychiatry which is nutritional
Psychiatry and so and this is a really
exciting time to be a
psychiatrist uh and it's also a really
exciting time or a hopeful time an
empowering time for people with mental
health conditions because we're finally
able to explore um root causes the real
root causes the deeper root causes of
mental health conditions that go beyond
things like what we're told all the time
which are these mysterious chemical
imbalances you know that need to be
addressed with medication We Now
understand that the real drivers the
primary drivers of mental health
conditions are inflammation of the brain
something called oxidative stress which
is why we're always told to eat more
anti oxidants and insulin resistance or
pre-diabetes which is now affects more
than 90% of Americans in your work you
talk a lot about the ketogenic diet why
is that so prevalent in your work was
the ketogenic diet energizes the brain
differently so it it really
fundamentally changes the brain's
operating system so when you switch from
a high
carbohydrate High insulin diet to a low
insulin which is us a low carbohydrate
diet ketogenic
diet the way that
cells uh receive
energy the the mixture of fuels that
they're using changes and that has
profound influences on just about every
pathway just about every chemical
pathway inside of that cell so it is as
though you are fundamentally changing
the brain's operating system uh in very
healthy ways that allow not brain cells
not only to work better but for uh but
for brain cells to heal so the longer
you stay on a ketogenic diet the more
healing the more brain healing can take
place and what is your sort of academic
and career experience what's that can
you run me through that sort of timeline
yeah so I uh got a degree an
undergraduate degree at Carlton College
in Minnesota in biology so I always have
loved science and biology understanding
how things work and uh then for years I
worked as a laboratory research
assistant different types of research
labs around the world Boston Munich
including in diabetes research until
I figured out what I wanted to do and I
decided that I wanted to go to medical
school so then four years of medical
school at the University of Vermont in
Burlington Vermont which is a great
place to go to medical school and then
four years of Psychiatry residency
training um at a Harvard program called
Cambridge hospital in Cambridge
Massachusetts
and then so that was 25 years ago that I
finished my Psychiatry residency
training and I've been practicing uh
Psychiatry ense and what does practicing
Psychiatry
involve what it usually involves for
most psychiatrists is psychotherapy and
medications and for some psychiatrists
only medications some psychiatrists
prefer to focus exclusively on
psychopharmacology or medication
management there are some psychiatrists
who choose to focus only on
psychotherapy and and and don't
prescribe medications but the vast
majority of psychiatrists offer a
combination of both medications and
Psychotherapy and when did nutrition
become part of your career well I I
never thought about the relationship
between food and the Brain once um
during medical school we had maybe two
or three hours worth of nutrition
lectures in four years and in four years
of Psychiatry residency we didn't talk
about food in the brain once so I
honestly had no idea how important it
was to to brain health uh so I practiced
conventionally as I was saying you know
medications and Psychotherapy for the
first 10 years of my practice and as
much as I loved my work I it was
becoming painfully obvious that most
people in my practice were just not
getting that much better like no matter
how hard I tried um and and it wasn't
just true for me you know it wasn't as
though I was thinking well you know I
don't have an maybe I don't have enough
experience or maybe I not reading enough
or maybe I need more supervision um when
am I going to be able to really be able
to help people because when I looked
around even very senior psychiatrists
who had been in practice for decades the
same was true for them I mean we had
we've been taught to think of mental
illnesses as chronic mysterious and
incurable and that the best way you can
help people is to support them with
medications and
Psychotherapy and uh but but that these
are lifelong illnesses that we really
don't understand very well and that we
can do very little about because you
there's like a significant social
component to mental illnesses as well
right absolutely I mean the brain the
brain is a very responsive organ and
it's listening to uh it's not just
paying attention to the food you eat
it's paying attention to every aspect of
your life how much light the brain
receives how much love you have in your
life how how much you love your work
what kinds of people are around you um
how you use your body exercise stress um
everything everything matters to the
brain but most people are led to believe
that food doesn't matter that much to
the brain and that's partly because
we've only recently started to think
about it but the other piece um is that
the information that we're given about
how to feed the brain and the body
properly is incorrect and so when people
are trying their best to improve their
mental health using nutritional
strategies those strategies fail most
people because those strategies are
grounded in the wrong information and so
a lot of people just think oh well you
know I I tried eating more Whole Foods
or right I tried uh you know I tried
putting blueberries on my oatmeal or
making my flax seed smoothie every
morning or uh eating more plants than
animals I tried all of those things and
they just didn't help very much so I'm
just going to go back to eating
everything in
moderation um because it doesn't seem to
matter but what's really great about you
inviting me here to talk with you today
is that people need to know how powerful
and intervention uh these nutrition
strategies can be they can help you in
ways no medicine can in days to weeks in
many cases people can experience
meaningful Improvement to their mood
their memory their concentration their
stamina their productivity um and and
their their mental stability their their
effectiveness in their lives if they
have the right information about how to
change their diet so you have to know
which changes are the ones that are
worth making and they're not the ones
we're used to hearing about is there a
particular case study that comes to mind
when you think about this is there a
most prominent case study or a first
case study that was a Eureka moment
VI I wouldn't say there was a Eureka
moment case in my life because I came to
it a in a different way uh my Eureka
moment really came through my own
personal experience I think a lot of
Physicians who uh practice nutritional
and metabolic
strategies most of us stumble into this
work accidentally because we're not
taught it and most of us stumble into it
either because a patient comes to us and
says hey you know I've tried this new
way of eating and that's why I'm so much
healthier than when you saw me a year
ago or the The Physician themselves
encounters their own health challenges
you know uses the conventional nutrition
approaches they don't help and they find
that they're kind of left to their own
devices to solve their own health
problems and that's exactly what
happened to me so when I was
experiencing all kinds
of uh health issues in my early 40s
despite doing everything correctly you
know eating uh low fat low cholesterol
calorie restricted diet um uh that was
high in fiber uh mostly Whole Foods and
exercising religiously despite doing all
of those things my health was declining
in my early 40s in ways that was true
for a lot of my patients as well and I
had no idea how to help my patients with
these issues these were things like
chronic fatigue and IBS and fibromyalgia
and migrain headaches very common in
middle-aged people and older and even
younger people nowadays so
when I encountered those issues and I
was working at Harvard at the time I had
access to all kinds of Specialists
caring intelligent thorough they did all
kinds of tests all kinds of tests and
they said everything is normal there's
nothing wrong of course there was
something wrong
but I I so I instinctively
started experimenting with my
diet uh and long story short short 6
months later trial and error changes
food and symptom Journal at the end of 6
months and this was back in
[Music]
2007 um the diet that I ended up on
Purely by trial and error was almost
upside down and backwards from what
we're told as healthy for us and that
was the diet that resolved every single
one of my physical health
symptoms but as a psychiatrist what
really got my attention was that it
improved my mental health significantly
and I wasn't even trying I wasn't even
aware that my mental health needed that
much attention I think like most people
I was walking around with suboptimal
mental health you know more anxiety than
was necessary than was I you know I
slumping in the middle of the day brain
energy you know faltering a couple of
hours after lunch coming home at the end
of the day and and being completely
spent and not being able to get anything
else done after 5:00 being really
anxious on Sunday night before Monday
morning work um you know being depressed
in the winter time I mean all of these
things we think of as really normal
we've come to expect so little of our
mental health we've come to expect poor
mental health as normal and it
isn't uh if you feed the brain properly
it works better and you can expect so
much more of yourself so when that
happened to me I thought well that's
interesting this diet seems to be good
for the brain which diet was that this
was a mostly
meat low carbohydrate low fiber low
cholesterol high fat diet no whole
grains no
legumes very few plant Foods mostly
Seafood meat poultry non-starchy
vegetables and fats from Whole Foods it
really was as simple as that and a Diet
similar to that is um uh one of the
starting places in the book so I have a
variety of different dietary strategies
people can explore in the book not just
one so it's different places for people
to grab on depending on what they feel
comfortable doing but that but that way
of eating resolved all of my physical
issues and mental health issues I wasn't
even aware needed attention
and that that
really was what inspired me to begin
studying nutrition I certainly did not
out and start recommending this dietary
pattern to my patients that would have
been Reckless I didn't know the first
thing about nutrition and based on the
little that I did know the diet that I
had ended up on should theoretically
kill me so it could be dangerous for
people and so I studied for years
independently took a graduate course at
the Harvard School of Public Health and
studied independently read everything I
get my hands on studied the the primary
literature the actual scientific studies
to try to understand okay why why is red
meat bad for us what's the difference
between red meat and white meat why are
whole grains good for us why are whole
grains good for us but refined grains
are bad for us why do we need a rainbow
of fruits and
vegetables uh are some of them more
important than others are they all
equally beneficial I mean all I just
became so curious about food I really
wanted to get to the bottom of it so for
years I studied nutrition and fell in
love with nutrition science and um it's
a lot of what I share in the book is all
these fascinating things about food that
most people don't know um and that can
really such as that it's interesting
it's useful it's empowering because if
you understand which foods contain the
nutrients the brain needs which foods
contain the ingredients that damage the
brain which foods are going to damage
brain metabolism and cause inflammation
and cause oxidative stress cause all
these things that we're told we need to
fight
with supplements and
superfoods um that's the real power the
real power in dietary change is not
adding special things to the diet it's
actually subtracting the things that are
harming the brain and working against
your best efforts it's it's it's just
like anything you know you don't make
money by spending money you make money
by by not spending money right so it
it's the power of subtraction what are
you not doing um and that's really Step
One is first Do no harm understand where
the harm is coming from in the diet
because it's not where you think it's
coming from it's not coming from the red
meat it's not coming from the
cholesterol it's not coming from the
saturated fat so if you understand where
the damage is coming from then you can
turn things around very
quickly you used a word there you used
the word explore um as it relates to
different diets that you've written
about in your book and that you know
that are available online
I from what I understood there you're
not saying that one diet is the right
diet for everybody you're saying that
it's almost the word explore suggests
sort of experimentation personal
experimentation and what worked for you
in that case might not necessarily work
for someone else in a different
situation is that accurate that's
exactly right and you're bringing up a
really important Point Stephen which is
that there are two levels of
dietary knowledge so one is that there
are fundamental nutrition principles
that apply to all human beings these are
the rules the cells require these
nutrients um and you must consume foods
that provide those nutrients to those
cells and you must exclude these certain
ingredients that can damage those cells
and you must keep your glucose and
insulin levels in in the right range for
your personal metabolism you have to you
have to nourish protect and energize
yourselves you must do that but then
beyond that so so those rules and and
the rules that you have to follow to to
get there are not are not not commonly
known but then beyond that there's the
personalization right because we are all
different we're not different in what
our cells need but we're different in
what we can tolerate we're different in
our metabolic Health we we're different
in how old we are how active we are what
um what conditions we we already have
what conditions we're most at risk for
what our goals are what our preferences
are what and and whether we have food
sensitivities for example um and so all
of those pieces
you know food intolerances and and
different different goals and different
aspects of our of Our Lives that's where
the personalization comes in and I teach
people in the book how to take these
fundamental principles so I teach them
what the fundamental principles are
which are very simple nutrition is not
rocket science um and and then show them
how to personalize it to their
metabolism to their preferences to their
goals what are the fundamental
principles let's start there so the
fundamental principles are nourish
protect
energize so nourish what does a brain
healthy diet look like and by brain
healthy uh we are talking about what's
healthy for all cells because it
wouldn't make any sense to uh for the
human body to require different diet for
every organ you possess so a brain
healthy diet is a diet that's healthy
for every organ in the body so it's good
for the brain it's good for the heart
it's good for the liver Etc so what is a
brain healthy diet it needs to nourish
protect and energize
nourish it must contain and be able to
safely deliver all essential nutrients
to your cells so you have to know where
those nutrients are you cannot and using
Whole Food principles and not including
supplements or specially fortified
processed foods you cannot meet that
goal without including some animal Foods
in your diet that's just the truth of
our
biology
protect protect the brain from damaging
ingredients so what damages the brain
inflammation which you can't see or feel
it's not as so the brain is red or
swollen or sore you we the brain doesn't
have nerve endings but many many people
have brain inflammation without being
aware of it that's a main driver of
depression and all kinds of other brain
conditions so you need to exclude
protection is not about addition it's
about subtraction you need to subtract
the foods from your diet that cause
inflammation
that caus something called oxidative
stress which is why we're always told to
eat more
antioxidants what we really need to be
told is what's causing all that
oxidative stress in the first place and
remove those things because the
antioxidant strategy really doesn't
work and energize nourish protect
energize the third principle is energize
which means the brain which is a very
high energy electrical organ it needs a
constant supply of high quality Quality
Clean burning energy and if you're
eating the wrong way your brain will not
will gradually lose its ability over
time to generate energy that's primarily
about getting your glucose and insulin
levels into a healthy range not just
your glucose although getting your
glucose levels in a healthy range is
extremely
important you have to go one step
further because underneath that glucose
you need to know what's happening with
insulin and that's that's a really EMP
powering strategy sort of Next Level
right so getting your glucose and
insulin levels down will allow your
brain to uh uh to energize itself in the
most clean efficient um and reliable way
possible nourish protect and
energize and then beyond there you said
there's a level above there so that's
the sort of fundamental level Beyond
there you go into sort of
personalization what's best for you and
is that where the sort of trial and
error comes into play exactly so these
principles nourish protect energize the
nourish you need to include some animal
Foods the protect you need to exclude
things like refined carbohydrates and
vegetable oils uh which are the
signature ingredients of the standard
American diet or standard Western diet
um and the the energize is is the the
glucose and insulin levels which for
some people this is some a level of
personalization begins here at the
energized piece because if you have
excellent metabolic health and we can
talk about what that means then you may
not need to eat a ketogenic diet to to
properly n to to really get those
glucose and insulin levels under control
and thoroughly energize your brain cells
but if you have significant metabolic
damage if you're sedentary if you're
older if you have pre-diabetes or type 2
diabetes um then you may need to reduce
the amount of carbohydrate in your diet
even from Whole Foods you may even need
to go to a ketogenic level and and
that's where that's where assessing your
metabolic Health understanding where you
stand on the insulin resistant Spectrum
the spectrum of metabolic Health that's
the empowering piece because if you know
where you stand on the insulin
resistance spectrum and you can get your
glucose and insulin levels into a
healthy
range you then you have tremendous power
over your emotional intellectual and
your and your physical health future
it's really the number one risk factor
for almost all chronic diseases mental
and physical so personalization starts
with a metabolic personalization so how
much carbohydrate can you safely
tolerate that's one example but then
there's another level of personalization
that has to do with how well does your
immune system work how how good is how
how robust is your gut function your gut
barrier many of us have lost our ability
to safely and comfortably tolerate a
wide variety of foods that we should be
able to tolerate and that's because our
environment
multiple multiple toxins in the
environment are have broken down a lot
of our defenses our gut barrier bloodb
brain barrier uh and and our immune
system has become overwhelmed by trying
to process lots of toxic ingredients in
our environment so these are things like
Plastics and pesticides and antibiotics
and um and and food additives and and
all kinds of you know ultr processed
foods that we were never designed to
handle these are really
stressful on the human body and they do
break down our defenses over time so
this level of personalization is very
much about trial and error but to save
people some of that frustration of trial
and error approaches I I give them very
specific lists of foods
um that that are more likely to be
culprits than others and so that helps
cut back on some of the trial and error
elimination this keto diet you um you
did a study on the ketogenic diet got
the study here the ketogenic diet for
refractory mental illness a resp a
retrospective analysis of 31 in
patients what is the ketogenic diet for
someone that might not know so a lot of
people think or they've heard about a
ketogenic diet as a weight loss diet um
they think of it may maybe it's a fad
weight loss diet um they think of it as
a very very low carbohydrate diet they
might think of it as a diet that's very
high in meat and dairy products um and
but actually the ketogenic diet was
originally created in
1921 more than a hundred years ago to
stabilize brain chemistry in children
with severe seizures um and this was
long before the availability of useful
seizure medications so these were
children who um uh were having multiple
seizures per day in many cases and so
the ketogenic diet was designed back
then created back then a very strict
version of the ketogenic diet um to get
as close as possible to to fasting
without Starving Children to death
because for
Millennia people had noticed that those
with epilepsy would often improve if
they were fasting but you can't fast
forever so how do you get close to
fasting this is the original fasting
mimicking diet how do you get as close
to fasting as you can while still
providing some nutrition so that was the
original goal of the ketogenic diet and
was very successful for seizures more
than 50% of children had more than 50%
and and adults as well it's it's since
been shown more than 50% response rate
in children and and adults and 10 to 20%
completely uh free of seizures following
a ketogenic diet how is it acting on the
brain what's it doing to the brain the
ketogenic diet does many many things
it's like a multi-purpose tool for brain
health so one thing it does because we
talked about how uh some of the root
causes of mental illnesses which are
only relatively recently a focus of
research are inflammation and oxidative
stress and insulin resistance the
ketogenic diet reduces inflammation it
reduces oxidative stress and it reduces
insulin resistance uh it also improves
the balance of chemicals in the brain so
a lot of people think of um uh mental
illnesses as problems with chemical
imbalances in the brain and these are
the chemicals that they're talking about
you might have heard of Serotonin or
dopamine or norepinephrine there are
others glutamate Gaba many different
chemicals in the brain are uh associated
with or in some cases even very much uh
causing mental health symptoms but the
question is what's causing those
chemical imbalances in the first place
and uh one of the things that's causing
those chemical imbalances is that
inflammation and oxitive stress but
another thing is that the brain is uh if
you're feeding it the wrong way it will
not be able to in many cases prod
produce energy reliably and if it can't
produce energy reliably all kinds of
things will go wrong and in quite
spectacular
fashion what actually goes wrong is
going to depend on who you are and
that's where our individual differences
come in so if I eat the if you and I
exactly the same bad diet depending what
runs in your family and how you've lived
your life to this point you might
develop Alzheimer's disease you might
develop bipolar disorder you might
develop type 2 diabetes you might
develop fatty Li disease um I might
develop completely different conditions
I might I might develop um
cardiovascular disease I might develop
depression um I might develop um ADHD it
and that's where the individual
differences are but all of these
conditions are just uh metabolic
malfunction really at at the heart of it
that's what's going on if cells aren't
functioning properly you will develop a
disease physical and mental diseases and
which ones you get it's really kind of
luck of the draw um but you have
tremendous control over what you are at
risk for if you understand how to help
yourselves operate at their personal
best can you tell me about what you
learned in this study and what this
study concluded yes so this was the work
of my friend and colleague Dr Alber Dena
he's a psychiatrist who's been
practicing in tulo France for more than
35
years so after witnessing a young family
member someone in his extended family
with autism and seizures improve within
weeks of adopting a ketogenic diet he
thought well I wonder if this diet could
help my patients especially my patients
who are not responding to anything else
that I have tried to help them
Psychotherapy medications
hospitalization
and so he invited 31 of his most
treatment resistant patients with
bipolar disorder major depression or
schizophrenia to come into the hospital
and voluntarily try a very mildly
ketogenic Whole Foods diet in the
hospital under his supervision to see
whether or not they would respond and
this was these were folks who these are
all adults these were people who had
been ill for an average of 10 years some
for as long as 30 years these were
people who were taking when they came
into the hospital at the beginning of
the study an average of five psychiatric
medications not at all unusual for
people with chronic mental illness and
all of them had one or more markers of
poor metabolic health obesity high blood
pressure high blood sugar things like
that so these were people with poor
metabolic health and poor Mental Health
heal and they eagerly came into the
hospital to try this intervention
because nothing else had helped them and
what was remarkable about what he
observed was that of the 31 people 28
were able to stay on the ketogenic diet
for more than two weeks which is what
you need to do to start to see
benefit every single one of them
improved to the point that 43% of them
achieved clinical remission from their
primary
psychiatric treatment resistant chronic
mental illness and 64% of them left the
hospital unless psychiatric
medication and all of them improved
metabolically as well and that you do
not see results like this in
conventional psychiatric care so there's
a few things that spring to mind when
you talk about the study the first is
that they were inside a hospital yes so
I guess that's a confounding Factor
potentially oh yeah well a blessing and
a curse yeah so a blessing is that um
the diet was fair was was very carefully
supervised six days out of seven they
were allowed to go home on Sundays okay
and which still I'm I'm just mentioning
but that but they had tremendous amount
of support and supervision and and
that's that's really really helpful when
you're switching from a standard High
carbohydrate diet to a low carbohydrate
diet they also had very careful medical
and psychiatric supervision which is
also really important uh because when
you when you change to a ketogenic diet
brain chemistry fundamentally changes in
ways that can at first when you're
transitioning from one operating mode to
another operating mode it's it's
stressful and sometimes you can feel
worse before you feel better MH and
medications can be affected so
medications need to be monitored and
everything everything changes these are
all really healthy CH your blood sugar
can drop your blood pressure can drop
especially if you're taking blood sugar
lowering medications or blood pressure
lowering medications if you switch to a
ketogenic diet it's so effective at
lowering blood sugar many Physicians who
prescribe blood sugar lowering
medications for diabetes need to cut the
diabetes medication in half on day one
in order to prevent dangerously low
blood sugar because you've got a
medication that's lowering blood sugar
now you've added a diet that lowers
blood sugar and this could be
potentially dangerous
the diet on its own is not dangerous
it's the diet in combination with
medications so you need to know what
you're doing and so yes in the case of
these um 31 adults so a certain
proportion of them was it 28 that
managed to see 28 31 283 had I just
restricted their calories for example
but kept them on whatever diet they were
on would I have seen an improvement as
well that study has not been done to the
best of my knowledge however you're
bringing up a really interesting point
so what a ketogenic diet is it's really
not about carbohydrate the definition of
a ketogenic diet is any diet that lowers
insulin levels uh to the fat burning
point so that if your insulin you can't
burn fat if your insulin levels are too
high and most people are walking around
with insulin levels that are high 24
hours a day they don't even come down
overnight because people are just eating
too much too frequently in the wrong
foods to get into ketosis or generate
ketones you need to lower your insulin
levels to the fat burning point and when
you and if and if you're burning fat
vigorously the liver will turn some of
that fat chop that fat into ketones
which are very small fragments of ready
to burn fat and these cross easily into
the into the brain and can be burned for
energy and they can Bridge any energy
gaps that may be there which many of us
have if these people had done the
Mediterranean diet would they have seen
the same consequences the medit oh sorry
say I imagine they were probably on the
western diet that like the American diet
which is ultra processed high sugar so
bringing them into a controlled
environment and just depriving them of
that would have surely caused just that
on its own would have been beneficial
yes so I wrote in the paper I I I and I
I mentioned this you're making a really
excellent point and I addressed this in
the paper is that because when you when
you change from a standard junky modern
diet to through a ketogenic diet that's
Whole Foods you're changing a lot of
variables right so how do we know that
it had anything to do with the ketones
right and and this is a good question
and a fair question and we don't know
the answer but new studies are helping
us to understand that but before we get
to that I just wanted to say the point
you're making is so important because
there are lots of ways to lower your
insulin levels so you can lower your
insulin levels through fasting
intermittent fasting you can lower your
insulin levels through exercise you can
lower your insulin levels through
calorie restriction if you restrict your
calories below 750 gram per day many
people will go into ketosis that's
another version of a fasting mimicking
diet made Popular by Dr wter Longo so
there are many ways to lower your
insulin levels um the ketogenic diet is
just one way to do that but the
ketogenic diet is the only way to safely
sustainably maintain a state of ketosis
longterm ter so you can initiate you can
get into ketosis using these other
strategies but it's it you can't fast
forever you can't exercise all day long
you can't restrict calories below 750
for the rest of your life but you can
safely and comfortably eat a a well
formulated ketogenic diet which is very
low in carbohydrate moderate in protein
not excessive in protein and relatively
higher in fat depending on your energy
needs indefinitely sustainably use the
word sustainably that that's kind of
always been my challenge with the keto
diet is being able to stay on it I mean
you saw in this particular study that
even trying to get people to do it for
two weeks resulted in some portion of
them dropping out yes um why is it so
hard to stay on the ketogenic diet I've
managed to do it for I I was saying to
you before we started recording once a
year around this time of year I do it
for about eight weeks and it has a
really profound impact on a lot of my
life it helps me feel more focused um my
body composition radically changes
faster than any other diet or thing that
I've ever tried faster than just
exercise Alone um I I sleep a little bit
better as well I
noticed but you've been doing it for a
long time you've been doing it for
roughly almost 10 years for the better
part of TW I mean more often I'll say
I've been following a ketogenic diet for
12 years and I agree with you it's not
always easy I'm not perfect about it
myself but I have been on the kog giant
diet The Lion Share of the last 12 years
it being hard is an important factor yes
because when you're trying to prescribe
it to somebody who is got you know
treatment resistant depression or is
really suffering in some way I imagine
they'll find it even harder than I do
yes and no okay so uh it's well it's
definitely there's no question about it
that's hard to eat a low carbohydrate
diet in a high carbohydrate world yeah
so there's that there's the
environmental Temptations and the social
Temptations and the habits and the
addiction sugar addiction is a very real
biochemical phenomenon so there's that
but
but it I mean I've been I I had a weight
issue growing up everyone in my family
did um and I've been on lots of
different diets in my life this is the
easiest one to stay on I can't say about
any other diet that I've follow for 12
years and the reason why is this diet
really stabilizes appetite hormones
so your cells are getting energized in
between meals you're not getting those
spikes and crashes in glucose which
cause spikes and crashes in appetite
hormones satiety hormones stress
hormones reproductive hormones uh brain
chemistry um you're not getting you're
not on that roller coaster anymore so
your cells are are are being satisfied
they're getting the energy needs
satisfied in between meals and
everything is quiet and calm on the
inside it doesn't mean you're 100%
protected against Temptation uh so I
describe it to my patients with food
addiction I describe being in ketosis as
a suit of armor you know the sword can
still get you but you but you know
you're not 100% protected but you've got
a real fighting chance and for for
anybody who's never tried a ketogenic
diet and been on it for at least I would
say six to 12
weeks it most people have no idea how
much easier it is um to follow
to follow a healthy eating plan when
their appetite is in good control a lot
of people know they've shifted into
ketosis without even checking their
Ketone meter because they can go for so
long without eating without even
thinking about food they can work
through lunch and not even realize that
they've missed a
meal most people the way we eat most of
us now are thinking about food all the
time you haven't even finished breakfast
and you're already thinking what what
can I have for lunch you're carrying
food around with you everywhere you go
you're eating at least six times a day
in many cases this is not the I mean we
would never have survived as a species
if we needed to eat six times a day so
we're not eating in a way that is that
is nourishing us and and satisfying us
we're eating in a way that's making us
hungry I find what you've said there to
be sort of true in my experience
especially in the context of the roller
coaster analogy so when I'm not on key
ketosis I do feel like sometimes I'm in
a bit of a roller coaster of like
Temptation craving Etc and then when I
do ketosis and I get past the first week
or two the the roller coaster seems to
stop right I'm I'm off the roller
coaster it's then maybe six eight weeks
later you're busy life happens you're
traveling you're tired that Temptation
Creeps in and it just takes that one
moment of weakness in my head to then
fling me off ketosis and all my effort
is gone and in my head the way I've
always thought about it and I'm sure
this is wrong but I've thought about it
like it takes a couple of days to get
into a state of ketosis and then once
you're in and I usually get a headache
yeah on my way into ketosis I feel a
little little bit bad on the way in and
then once I'm in there it's fine so when
I have something that breaks my keto
this is what I refer to me and my
girlfriend talk about I've broken my
keto whatever I think oh my god I've got
to go through another headache and
another five days of you know uh getting
back into it
what is that correct it's a very common
experience because there are these
adjustments uh that happen inside uh
with your physiology uh as you're
shifting from one operating system to
another when you're shifting from
carbohydrate burning system to a more
you're shifting your ratio of your fuels
so the body and the brain are hybrid
engines so we're never burning 100% fat
um we're burning a mixture of of fat and
carbohydrate when you're shifting from a
from a system system that's fueled
almost entirely by carbohydrate almost
all the time to a system where you're
burning more fat than carbohydrate um
that's uncomfortable for some people
shifting back and forth
especially if what they have if if the
reason why you've quote broken your keto
is because you've had something um that
has a lot of refined carbohydrate in a
lot of sugar or flour in it for example
um so it depends on what you've eaten
and how much and for how long um but but
many people do experience the so-called
keto flu when they are shifting from a
carbohydrate based system to a fat-based
metabolism and some of this can be uh
much of this can be prevented in a
couple of different ways one is with
electrolyte supplementation
supplementing electrolytes to keep your
your salt balance even as you're
transitioning and another uh is by
transitioning slowly onto the ketogenic
diet rather than all at once and so and
there are many there are other tips in
the book about how to do this more
comfortably but those are the two big
ones uh and going slowly so in the book
I don't recommend that people start on a
ketogenic diet just straight away like
learn about it on a Monday started on a
Tuesday but ease into ketosis over a
week or two and uh there's a there's a
kind of a moderate carbohydrate plan in
the book that allows people to do this
so you you follow that plan for a couple
of weeks to gradually lower those
glucose and insulin levels it's going to
be a lot more comfortable it's be a lot
less of a shock to the brain and body um
and and if you're supplementing
electrolytes and going slowly most of
these quote keto flu symptoms will uh
will not occur or they'll be very brief
and Mild so um again these are posit
it's a positive change to have these
electrolyte changes and um it's it's all
of these things are are good but there
is this transition period which can
sometimes be uncomfortable and this is
um not to say that it's dangerous again
it's a very we're designed our biology
is designed for us to be able to shift
back and forth between fat and
carbohydrate as fuel sources but many of
us have lost some of our metabolic
flexibility because we've done some
damage to our metabolic engines by
eating the wrong way for too long so we
don't shift as comfortably back and
forth as we used to be able to I guess
most people don't even know what foods
are included in a keto diet because most
diets are restrictive to the point that
you know people think they just make
your life miserable but what are the
sort of big misconceptions you've seen
with the foods you're able to eat on a
ketogenic diet yeah so because a
ketogenic diet it because the definition
of a ketogenic diet is any way of eating
okay that lowers insulin levels enough
to turn on fat burning and generate
ketones in the
blood because because it's about insulin
it the it's not a food list so you can
you can it's not about plants and
animals it's not even about fat or
carbohydrate it's about understanding
how to lower your insulin levels which
you can do with a vegan dietary pattern
with a vegetarian dietary pattern uh
with an omnivore dietary pattern um uh
with or even with a carnivore dietary
pattern so whatever your dietary
preferences are you can get the benefits
the brain healing benefits of of ketosis
so it's not about the foods you're
eating um it's it's more about
understanding what raises and lowers
insulin the things that raise and lower
insulin are refined carbohydrates Whole
Foods carbohydrates refined proteins
like protein powders whole food sources
of protein and guess what barely touches
insulin at all fat fat is metabolically
the quietest and safest macronutrient
you can eat because it barely stimulates
insulin is ketosis a state like do I is
it like a binary State like now I'm in
ketosis and now I'm
not so yes but there's there's a yes um
let me put it this way that most experts
will agree
that um in order to be quote in
ketosis um your level of beta hydroxy
butter rate on a blood Ketone meter uh a
blood Ketone meter U um is PR finger and
and put a drop of blood on this little
test strip and it will read the amount
of a particular Ketone in the blood
called beta
hydroxate and it it will give you a
reading if that reading is point is 0.5
Millo or higher you are in ketosis in
ketosis so what does that mean why why
is the cut off 0 five because three
things have to happen for you to get to
at least 0. five one is your glucose
levels have to come down the second
thing is is your insulin levels have to
come down the third thing is you have to
burn off a certain amount of the stored
starch in your liver we have a a storage
tank for carbohydrate in our liver it's
not very big it holds less than a day's
worth of carbohydrate because really as
animals we're designed to store energy
as fat carbohydrates there for quick
Energy emergency short-term um the fat
we For Better or For Worse we have
almost an unlimited capability to store
fat we can store months and months and
months wor of fat and so um but we can
only store a very small amount of
carbohydrate so if your storage tank in
the liver is full your body will not
switch to fat burning because it says oh
we've got plenty of starch to burn let's
start there once it comes down to a
certain point the body goes oh running
out of energy let's go to fat now and
that's when the the liver will start
breaking fat down whether it's fat on
your body or fat from your plate
and start chopping it up into these
ketones and uh but so those three things
have to happen and once that happens
that you'll see the Ketone levels rise
on the meter so most people who are not
eating a ketogenic diet are walking
around with Ketone levels either
undetectable or they're 0 2 or they're
three they might they might float up
into above 05 every once in a while if
they're not eating for a long time or um
uh or if they've just exercised but for
the most part most people uh eating a
typical diet are not in ketosis and when
you get above 0.5 a lot of metabolic
magic starts to happen because there are
lots of Pathways in the body and brain
that uh are not very active unless
you're in ketosis and those are the
healing Pathways the recycling and
maintenance and cleanup Pathways the
recovery Pathways all of
us this is something that I I came to
appreciate a number of years ago as I've
been studying this is that
there are many people unfortunately or
fortunately there are many people who
discover with mental health issues that
they need to be in ketosis long term in
order to be
well but I've become convinced by the
science that all of us need to be in
ketosis um at least intermittently all
of us need to spend some time in ketosis
on a regular basis or else we can't heal
we'll only be it it's like a it's like a
manufacturing plant where the plant is
just running 24/7 12 months a year and
and they never take time to replace the
parts or clean up the floor or you know
they never do any maintenance work or
repair work and So eventually everything
breaks down and when you say ketosis
again you're not saying the the keto
diet you're saying the low levels of
glucose um and Insulin exactly in the
blood and that can be achieved by
calorie restriction potentially fasting
I guess you could achieve it and other
diets like the Mediterranean diet if
administered in the right sort of doses
right well um we we should come back to
the Mediterranean diet a minute but
first the first part of your question is
important because ketosis is you can as
you said you can get into ketosis a
variety of different ways if you're
eating properly and this would have been
our evolutionary Heritage our ancestors
especially our prehistoric
ancestors um they have access to these
lots and lots of refined carbohydrates a
long time ago um they were eating
carbohydrates from uh Whole Foods uh
fruits and starchy root vegetables right
and uh and so even grains and beans are
very very relative relatively much newer
sources of carbohydrate so let's think
about fruits and vegetables but so they
they would have been we can only guess B
look looking at their diets we don't
have proof of this but think about it if
you're eating in a way where your
insulin levels are allowed to come down
overnight if you're eating if you're
eating a a balanced diet so to speak but
it's got everything it needs in it and
it's not giving you exaggerated spikes
in your glucose and exaggerated spikes
in your insulin and you're not eating
six times a day or all day long your
insulin levels will naturally come down
overnight and that will that will allow
you to go into a healing mode so I
believe that if people have the right
information about what a healthy diet is
supposed to look like they may may not
even need to in many cases especially if
you're younger or athletic or don't have
a lot of metabolic damage already um you
may not need to you may not need to
lower your carbohydrate intake during
the day you might just need to be
careful about what kinds of carbohydrate
you eat and how often um so for example
it's known that in children um they're
who are eating a regular diet many of
them wake up the next morning in ketosis
they're metabolically much healthier
than uh we are as we get older so
they're much more metabolically flexible
um and uh so now they didn't go on a
ketogenic diet they were eating a
regular diet they slept overnight didn't
eat anything the next morning they're in
ketosis that's not true for all children
but it's true for enough children that
we know it's possible most adults it
takes them several days at least to get
into ketosis even if they're not eating
anything at all so f fasting can take 2
to 3 days at a minimum for most people
to get into ketosis but some people it
can take a whole week and you talked
about children there one of the big
conversations at the moment around
children is the the rise in ADHD
diagnosis and there's a lot of different
sort of thoughts on the causal factors
of this and what is it that's making
children be diagnosed at higher and
higher rates with these sort of neurod
Divergent
disorders is there any evidence to
suggest that what we're eating is
playing a role in these neurod Divergent
disorders
yes the first thing I would like to tell
you about is that there were studies
quite a few studies back in in 80s 90s
and early 2000s in Europe by variety of
different research teams that explored
exactly the question you're asking and
what they did um was they placed
children with ADHD some quite severe
ADHD even Hospital level ADHD
and put them on something called a few
Foods diet this is uh the scientists
call it an oligo antigenic diet which
just means it's kind of a low allergen
diet so it's they removed all of the
common culprits and they focus mostly on
just a few Whole Foods uh and and and a
few extras so very specifically
describing this diet most of these diets
were um chicken lamb fruits vegetables
um and sometimes they throw in some
apple juice and margarine because they
couldn't use butter because Dairy is a
common allergen so but these were mostly
Whole Foods diets you know uh uh poultry
red meat fruits vegetables um and there
62 to 82% response rate to these diets
no matter which study you looked at and
in some of these studies there was a 70%
cure rate within weeks of changing the
diet to a few Foods diet so what does
this tell us
it doesn't tell us which foods were the
problem it tells us that food can be the
problem that if you make diet the right
dietary changes it's possible for
children even with very severe ADHD to
improve within weeks to the point that
they no longer qualify for having ADHD
anymore because there's a change in the
symptoms oh yes um the children's uh
Behavior as rated by parents and
teachers um and the researchers
themselves so just uh did some research
to find some stats on this sure diet
modification isn't widely prescribed as
a way to alleviate ADHD symptoms is it
it says as of 2019 major health
organizations including the American um
Academy of Pediatrics and the National
Institute of Health and Care Excellence
do not recommend dietary modifications
as standard treatment for ADHD due to
insufficient
evidence a 2014 review found elimination
diets might offer minor benefits in sub
in a subset of children particularly
those with food sensitivities or
allergies however these benefits are not
substantial enough to advocate for
widespread dietary changes in ADHD
management so what I would say to that
is uh there are multiple studies all
pointing in the same direction that I
think give parents and families and
children tremendous hope with really no
risk MH what are we doing
instead we're medicating children we're
giving children
stimulants which can stunt their growth
make them anxious um and and cost money
MH and is I mean I I'm one of the
reasons I do this work is
because I really don't think that for
most people the right thing to do is to
medicate our way out of this situation I
mean just about every mental and
physical health issue we have is we
think about we've just kind of been
condition to think about medications as
the solution but medications don't solve
problems they cover them up and what we
really want to do is want to get to the
root of these problems and not just
treat them which nutrition interventions
can do in many
cases but perhaps even prevent them from
happening in the first place can they
all be treated by because you know I I
was I guess technically diagnosed with
ADHD but I don't take any medication for
it I'm it's a personal choice I
personally just um don't think that the
net impact has on my life is worth
taking any medication I also have
friends with ADHD who have significantly
worse symptoms when I say worse I mean
more pronounced symptoms than I do so my
personal decision was just not to take
the medication however I sat here with a
guy called Dr aan Who has a daughter who
had ADHD she got the medication and it
turned her life around like she went on
to become super successful but was like
struggling in school so
it's really difficult isn't it because
it's such a personalized sort of
personal decision
and some people have it more extreme and
in a way that makes their life more
dysfunctional than others you know and
my some some of my friends do really say
they say I took this medication for my
ADHD or my my tension issues whatever
and it's been revolutionary for me they
just like they they just offload on me
how profound it's been for them
so I guess it goes back to being a
personal it does but you
know so I have a lot of experience
treating ADHD because I worked for two
years at an ADHD Specialty Clinic called
the Hallowell Center outside Boston I
also worked for 13 years in college
mental health at Harvard and at Smith
college and saw lots and lots and lots
of students with ADHD most of who
actually had it some of who didn't
who're just looking for stimulants but I
I can tell you as a psychiatrist who's
prescribed medications for 25 years the
stimulants are some of the most
effective medicines we have in our
toolbox for the people it works for it
works very very well so and it can be
life-changing a lot of people think of
ADHD as oh a minor issue oh you can't
concentrate or or maybe you're Daydream
or maybe you're fidgety or you know
maybe you get distracted 8 HD can be a
really serious condition just like all
mental health conditions it exists on a
spectrum of mild to very severe and so
people with ADHD are at much higher risk
for suicidal ideation they're much
higher risk for substance abuse they're
at much higher risk for accidents
they're much higher risk for depression
for
anxiety these and and twice the twice
the rate of divorce in people with with
adults with ADHD these are serious can
be for some people
really disabling conditions people
cannot function in their lives they
can't function in their relationships
they can't hold a job you know they they
feel so frustrated and
Powerless I mean I was telling you that
I worked with students in in in you know
these Elite universities right these are
very intelligent people who were
struggling 10 times harder than their
peers in in classes they had to work so
much harder they had to stay up four or
five hours later than everybody else and
and and they did because they were
hardworking but they're really suffering
and this discrepancy
between how smart I am and how much I
think I should be able to do and how
much I'm actually able to do makes me
feel bad about myself right they feel
bad about themselves and because they
know they're capable of more but they
can't get there and it's a real
biological condition now the great thing
about this is a perfect example that you
could we could have this conversation
about any mental health condition but
ADHD is a great example
because there's always a risk benefit
analysis when you're thinking about how
are we going to treat this condition uh
so do you want to take medication what
are the pros and cons of that does the
medication work for you does it give you
side effects can you access the
medication uh can you afford the
medication um how hard is is lifestyle
change for you one of the most powerful
interventions for edhd and I think
probably the a just maybe one of the
most Stellar examples I can think of is
this change your lifestyle to suit your
strengths play to your strengths and
don't try to swim upstream against your
weaknesses people with ADHD often have
tremendous talents in certain areas and
are tremendously gifted in certain ways
because they can make connections
because they don't always think in a
straight line because they they often
have very diverse interests and they can
pull different kinds of information
together and you know given the right
path they can be hugely successful right
but that's not possible for everybody
and for more severe cases of ADHD it's
not possible at all has there been any
studies on the link between the
ketogenic diet and ADHD so not yet but
I'm I'm very excited to to to be
involved in two brand new studies of the
ketogenic diet for ADHD so one is a uh
ketogenic diet for uh adults with ADHD
and depression that's getting started at
Oxford University in
2025 and the other is a study of uh
ketogenic diets for ADHD and adults at
the University of Michigan it's also
going to be starting in 2025 we have no
data on ketogenic diets and ADHD but we
have good reason to believe the reason
we were able to get funding for these
studies is because there's there's
reason to believe that it could be
useful and because when you look at ADHD
you see Clues to poor metabolic health
so for example children with obesity are
twice as likely to have ADHD obesity is
a marker for insulin resistance adults
with type 2 diabetes are twice as likely
to have ADHD type two diabetes is severe
endstage insulin resistance and the
ketogenic diet is the most effective way
to address insulin resistance that we
have at our disposal is it hard to
establish cause and effect there
I was thinking about the the diabetes
one where if you've had ADHD maybe your
life has been harder again I don't know
what I'm talking about here but maybe
your life has been harder and if your
life has been harder you're more likely
to be obese potentially if you've been
gone had more stress and you've you know
you've had a a worse a worse more
challenging job and so is it you
know and will will a test be able to
exclude these sort of confounding
factors to the point that we'll know for
sure I think that would be a very
difficult study to to design but I think
what I can tell you from my clinical
work CU I work I'm a general
psychiatrist so I see adults of all ages
and with all psychiatric conditions from
major to minor and I've worked as I said
with people with ADHD of you know
hundreds and hundreds of patients with
ADHD what I can tell you is that it's
the same with medication um if someone
comes in and says to me uh I can't tell
if this medication is working um uh so
should I keep taking it and I'll say
well you know if you can't feel it
working then it's not working uh so when
the diet works it works regardless of
what's going on around the person so and
this is true for all conditions that
I've worked with so people with bipolar
disorder people with depression people
with ADHD people with PTSD people with
anxiety as you have said we talked about
the ketogenic diet is not easy to stick
to right people fall off the ketogenic
diet all the time uh sometimes
accidentally sometimes intentionally
right and you can see their symptoms
come back within often 24 hours even
though their external factors have not
changed so life hasn't changed it's the
diet and when you follow the actual
Ketone levels daily you can make that
correlation so what's really exciting
about both of these studies is it's not
just getting somebody into ketosis it's
it's
tracking um on a data to-day basis their
Ketone level and their attention
symptoms and seeing if we can see them
go up and down together and we've always
get a little bit of data already from a
pilot study at U um uh um by Ali Houston
at uh at Oxford University we're
starting to see some signals there but
it's too early really uh we need to
actually launch the official study so in
my
patients it's it's a phenomenon I've
seen over over and over and over again
um a great example is I have a
patient um that I worked with for a
couple of years who had a a condition
called bipolar disorder type two so it's
a it's a form of bipolar disorder uh
bipolar disorder people used to call
manic depression you've got periods of
mania often followed by periods of deep
depression bipolar type 2 is a milder
form where you don't get quite as manic
um and but you still can can get very
depressed so he had bipolar to um and
whenever so so uh he came to me because
he wanted to try a ketogenic diet for
bipolar disorder because um uh uh he had
heard it might help so the other issue
he was dealing with was that he um and
his wife were having some difficulties
some difficulty in their relationship
that had started up a few years before
and you know every time they got into an
argument he would want to die and he
would start to think about ways of
killing himself
self every single time he went on the
ketogenic diet the suicidal ideation
went away even though his wife had not
so he used to associate the depression
with the marriage but he learned over
time to associate it with his metabolic
state that when he was in ketosis he
could then imagine other ways of coping
with the stress in his marriage other
than just killing himself so he it a lot
of people say to me that the ketogenic
diet gives this space it allows them to
pull back and see things from a
different perspective it buys them time
perspective it's like a buffer so that
people people aren't reacting as
reflexively to difficult situation
situation hasn't changed but people are
able to deal with the situation in a
more effective way they feel they have
more control not just over their
emotions but also over their behaviors
and how they react to situations
at my company flight Studio which is
part of my bigger company flight group
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below and for people that have
food addictions and binge eating
problems the ketogenic diet I guess it's
knocking you off that roller coaster
what well being in a state of ketosis is
knocking you off that roller coaster of
craving eating craving eating craving
eating is that accurate is that what
it's doing yes so um the ketogenic diet
by lowering and stabilizing glucose and
insulin levels the thing about insulin
is that a lot of people think about
insulin as a blood sugar regul later
they think of it as oh you know it uh
when your glucose goes up the insulin
brings it down and and that's true but
that's it's just one of many important
roles that insulin has it's the one it's
most famous for but the thing that uh
what is not well known is that insulin
is so much more than a blood sugar
regulator it's actually a master
metabolic hormone and it's regulating
the activity of every cell in the body
every cell has an insulin receptor on
its surface multiple insulin receptors
to pay attention to the insulin level in
the blood and
so uh when you're on a glucose and
Insulin roller
coaster that's just where the trouble
begins insulin is talking to and
controlling the behavior and levels and
activity of many other hormones in the
blood including stress hormones like
adrenaline and cortisol um reproductive
hormones like estrogen and testost
cherone your blood pressure regulating
hormones your satiety hormones the
hormones that make you feel full after
you eat your hunger hormones so many
other hormones are on this roller
coaster uh that you're unstable from
within and people often will think well
I'm stressed and that's why I'm eating I
I I feel really anxious um I get
irritable I get stressed I'm hungry I
need to eat and then I feel better and
that's true they will they will feel
better for a few hours
but what what happens four to five hours
later if they've eaten something that's
spiked their glucose and Insulin again
is they're going to get there's this
great study with um healthy teenage boys
they took healthy teenage boys and they
gave them either a sugar-free
Cola uh caffeine-free or a caffeine-free
Cola sweetened with sugar and the boys
who had the sugar sweetened Cola their
adrenaline levels their stress hormone
levels of adrenaline
quadrupled four to five hours after
drinking the soda and the boys who drank
the other soda stayed flat it's the food
that's causing the stress that's causing
the food eating you so there's this
vicious cycle if people understood that
most of what's happening there it's not
your fault that you want to overeat
those Foods they are designed to be
overeaten like chemical Engineers these
this is very very intelligent um
engineering that's going on very clever
and uh you will sell more of a product
if you make it irresistible and if you
make it
unsatisfying how many people feel that
they can't control their consumption of
certain foods that's by Design if you if
you want to keep eating it you'll buy
more of it if you eat real
food you have to stop after a little
while they're so satisfying things like
meat Seafood poultry eggs fruit veget
Veges even fruits fruits some people
will overeat fruit but but fruit has
fiber it has water it's really hard to
eat you know 10 pieces of
fruit very easy to drink you know a
bottle of several bottles of fruit juice
very easy um to eat multiple packages of
candy because those what happens with
ultr processed carbohydrates these
refined carbohydrates they blow past
your hormonal stop signs and that's not
your fault but if you understand that
that's what's happening then you can
takes a few days you got to step away
from them but but on the other side is
tremendous freedom and
control the gentleman you mentioned in
that case study a second ago you
referred to as Carl which I guess is a
cloaked name um he's the one that had
the bipolar disorder uh no Carl is a
different case ah okay tell me about Co
yeah so I opened the book with the story
ofl Carl who has you know generously
allowed me to share his story um a
gentleman great guy in his
mid-60s who had had lifelong depression
and
anxiety and uh for years he he didn't
seek any treatment and then maybe about
15 years or so before he consulted with
me he went to an A A psychiat A
Psychiatry specialty clinic for some
specialized brain Imaging and uh
extensive evaluation and lots and lots
of specialized tests and he left the
clinic with thousands of dollars later
with three diagnosis depression anxiety
and ADHD and three prescriptions one for
depression one for anxiety one for ADHD
so he started those
medications and his depression got a lot
better but he then uh had a brand new
problem on his hands which was he was
becoming Manic and he had never had
Mania before so he was been
uncharacteristically um energetic and uh
um uh irritable and unpleasant and so it
was changing it was changing his
character his personality a certain his
behavior in a certain way that was
becoming very unpleasant at work and at
home so he then turned to marijuana to
try to take the edge off developed a
marijuana addiction now he's got another
problem and so he thought to himself you
know this isn't this isn't what I signed
up for I was trying to solve a problem
and now I've got two new problems on my
hands so he took himself off the
medications and said you know I I I
can't use medication medications is not
for me I'm going to try to manage my
mood issues my depression anxiety with
rigorous exercise I'm going to let
exercise be my medicine and he started
cycling uh bikes over a 100 miles a week
and it actually helped a lot it didn't
completely resolve all of the symptoms
but it brought them down to um a very
manageable level uh for years so
exercise was his medicine exercise
improves metabolic health and so he was
still eating a standard American diet
he'd never tried any dietary changes
before and then um what happened is as
he entered his 60s the depression
anxiety started to rise in the
background exercise wasn't working quite
as well as it had and then uh just
before he met with me something
stressful it happened at work and it was
essentially a shift in his job
description which was making him anxious
and he started experiencing very
suddenly these bouts of um agitation and
anxiety and restlessness and exercise
being his medicine he would he would
cycle on the weekends
and at night if it was a if it was it
was happening on a week night a work
night he would be walking because he
couldn't bike at night when it was dark
he would walk sometimes eight even 25
miles to try to get rid of this excess
energy and he said I don't have time for
this I can't exercise enough to keep my
symptoms under control he didn't know
what else to do he starts searching
online for Solutions came across
information about carnivore diets and
mental health contacted me for a consult
and said I want to try the carnivore
diet for my for my
anxiety and I mean there were lots of
other things we could have done uh to
improve the quality of his diet but this
is what he wanted to do because he was
hoping that would bring him the most the
the fastest relief so switched to a
carnivore diet 3 to four pounds of fatty
meat per day mostly pork and beef this
was dairy free no plants and uh he
checked his ketones using urine testing
which Which is less expensive than blood
testing uh he's in mild ketosis every
day using urine strips and uh he started
to improve by week three by week six his
score was zero on all his depression and
anxiety scales he had no
symptoms at all of of depression anxiety
not just of those recent extreme
symptoms that he was experiencing but
the symptoms that went back his entire
life that had never completely resolved
before so he said you know I I this is
the I've never felt this well in my
entire life and so this is the power of
these strategies is they don't just
reduce symptoms a little bit they
actually have the power to heal the
underlying problem in ways that I mean
this is a phrase I've heard so many
times I feel better than I've ever felt
in my entire life you don't hear that
when you prescribe medications for
people generally that was in
2019 was it uh I couldn't tell you what
year but that sounds right how is he
doing now yeah I mean we we are still we
we still talk with each other uh several
times a year he's doing very well in
fact so he one of the interesting things
about what happened with this diet is
that during that long period of of
intermittent
agitation uh he you know he's a very
physically fit guy because of all the
exercise and he and he was lean he lost
10 pounds during that period of
agitation that he could not afford to
lose when he first started working with
me he was underweight
and despite eating four pounds of fatty
meat per day he couldn't regain that 10
pounds unless we added uh back some
carbohydrate into the diet this is
really this is a subtle point but for
athletes sometimes especially in the
early phase of the
transition um there needs to be a
certain amount of carbohydrate in the
diet um to support high performance he
didn't stay on the carnivore diet no he
did not so he was on the car carnivore
diet for many months and then be but
because he couldn't regain that weight I
asked him I said well you know I think
we need to put some carbohydrate in to
help you uh regain this weight and so I
asked him which foods he missed the most
gave him a list of Whole Foods to choose
from and the things he missed most were
uh potatoes and yogurt so some starchy
root vegetables some plain unsweetened
yogurt um up to about 100 grams of
carbohydrate per day seemed to be about
right for the days when he was e excuse
me exercising on the days when he wasn't
exercising he would cut it back so he
was tailoring it to his personal energy
needs and so so this is another um uh
interesting thing about what happened
for him is that um I mean his his scales
are still at zero but he has been uh as
we've talked to each other on and off
over the years he has been able to make
adjustments to his diet understanding
the principles if you understand the
principles then you know which changes
you can get away with and which changes
you can't and he has stayed well there's
a couple of key things people always
talk about when they hear the carnival
diet the first is they say there's
nutritional deficiencies to the diet
that aren't like sustainable so if you
eliminate certain food groups like
fibers vitamin C's vitamin E magnesiums
Etc then which are essential
nutrients then you're going to have
problems so a carnivore diet
theoretically does provide all essential
nutrients so if you look at what is
inside animal Foods you will find all
essential nutrients you can't say that
of any plant food there's not a plant
food on Earth that can that provides all
essential nutrients animal foods can uh
I would say meet Seafood poultry eggs
are missing a couple of nutrients and
dairy is missing even more um but uh
meat seafood and poultry contain every
nutrient we need the question is how
much do you need like fiber oh well
fiber is not a nutrient oh okay but do
you get fibr in a carnivore diet there
are different definitions of carnivore
but the strictest sort of purest
definition of carnivore is animal Foods
only and fiber comes from plants so it's
fiber free a true carnivore diet is
fiber free so could you lost on a true
carnivore diet without getting some kind
of like microbiome issue or some kind of
because you need fiber right why thought
it was good for like digestion and your
microbiome and stuff like that what does
it do a lot of people tell me that it
prevents glucose going into the blood or
something where's the glucose coming
from so you don't need it fiber fiber is
very helpful and I spell this out in the
book so because there's we have a lot of
Hal truths in our minds about food um
even people who are paying really close
attention to the to nutrition
science have a lot of half-truths in
their minds about food so yes fiber for
example you're exactly right lowers
glucose spikes but the glucose is coming
from a diet that's too high and sugar
and so you won't get glucose spikes if
you regulate your glucose levels um so
so that's one uh interesting thing about
fiber so if you're eating a high
carbohydrate diet fiber can soften your
glucose spikes and that's a plus but
there's a more effective way to lower
your glucose spikes is to not get a
glucose spike in the first place um and
that may not require taking all the
carbohydrate out of your diet it might
just mean lowering it to your personal
tolerance um another thing people often
say about fiber is that it sweeps your
colon clean of toxins and kind of um um
and uh that might otherwise build up and
cause problems but fiber um there's no
evidence that fiber is sweeping anything
clean or there's never been a study that
demonstrates this it's really just a
belief about what we imagine fibers
being like the broom of the intestines
but there's no that that's just a belief
there's no science behind that
whatsoever um the the intestines clean
themselves the lining sheds regularly
actually very frequently and has and the
border of the intestines um sweep
themselves clean so they the intestine
knows how to take care of itself that
way but the biggest myth about fiber is
that it's good for digestion because
fiber by definition is
indigestible by humans so there are two
kinds of fiber there's soluble and
insoluble and the soluble is um you know
the kind that holds water it's like in
an apple and the insoluble is the kind
of tough stringy Woody stuff that you
might find in like broccoli for example
so the soluble fiber the bacteria and
the lower parts of our intestine can
ferment that to a certain extent um but
uh but then we but then we can't make
use of the sugars that it's releasing um
right here fiber traditionally
considered essential for feeding
beneficial gut bacteria and promoting
regular bowel movements yes okay so a
couple of things to unpack there so one
is that the uh a lot of people uh there
are quite a few papers on this uh
claiming that we need fiber because we
need to feed our cells butyrate which is
a breakdown product of fiber but
butyrate if you think about what a
ketone is it's beta hydroxy vate feeds
the intestinal cells just as well so you
don't need to eat fiber to feed your
cell's butyrate if you think that the
cells need butyrate then you can get it
from a ketogenic diet um so I explained
that in the book too is that there's
more than one way to generate that
molecule can someone exist on the
carnivore diet like the extreme version
of the carnivore diet for a long time
without any
supplementation so you we really don't
know and we really don't have any
long-term data on on any dietary pattern
I think this is really important for
people to understand is it's very common
criticism of diets that we feel
uncomfortable with or might be worried
about like ketogenic diets or carnivore
diets because they're so different from
what we're told we're supposed to eat
there's a lot of fear and worry uh about
them and so think well okay it's it's um
it's normalized my blood sugar level I
used to have type two diabetes um you
I've lost 50 pounds um my depression
went away um my uh I normalized my
coronary artery calcium scores I'm at
lower risk for cardiovascular disease my
triglycerides came down um you know I
feel better I'm I in every way like all
of my health markers have improved and
so when you show people study after
study after study of a ketogenic diet um
improving multiple aspects of metabolic
health and physical health and mental
health it's cured my seizures it's cured
my bipo whatever it was the only the
only last sort of the last thing
somebody could say is well well yes okay
it's made you extraordinarily healthy
now but I wonder what's going to happen
20 years from now MH nobody can tell you
that because there's no way you could
design a 20 year long study of any diet
so you could say this about the
Mediterranean diet you could say this
about a carnivore diet you could say
this about a vegan diet well vegan diet
unsupplemented is is fatal um it's it
has dangerous nutritional holes so why
aren't we saying this about vegan diets
when we can look at a vegan diet and see
that it that that it's incompatible with
human life unless you eat fortified
processed foods or supplement which most
people in the world cannot do um we look
at a carnivore diet and you can actually
find all of the nutrients in these
animal foods and that's the diet that
you're more worried about because
theoretically
longterm something bad might happen now
I am not at all saying
that a carnivore diet is the right diet
for everybody um or that it's even the
right approach for everybody to consider
but I think we have to keep an open mind
and stay curious and look at the biology
of food and allow people to make their
own I'm nutritionally pro-choice which
means I would if you came to me with a
mental health issue um I would support
you in optimizing the diet of your
choice and making it as brain healthy as
I possibly could because I because uh
it's very important that you feel
comfortable with the diet that you're
eating and so there are lots of ways to
do that but I think it's really
important and one thing I encourage
people to do in my work and in my book
is to open our minds and get curious
about food the biology of food the
biology of the brain because most of
what we hear about nutrition doesn't
come from biology it doesn't come from
Clinical experiments or uh information
about how cells work or about what's
actually inside food it comes from this
type of study called A nutrition
epidemiology study which is just
questionnaire based guesswork untested
theories about what we should eat most
of what we believe about nutrition is
untested theories wild guesses and
Wishful
Thinking many of the people that choose
a keto diet do it for very sort of
superficial reasons sure you know I
think it's probably one of the reasons
why I do it once a year um for a couple
of weeks um why does it help you to lose
weight is that again just because of
calorie
restriction so it's insulin so it it
everybody out there who's trying to lose
weight they need to know one thing and
it
works if you cannot burn fat if your
insulin levels are too high so if you
know what rais
insulin you can lo you can turn that
insulin knob down if you know how to do
that you will lose weight it's a
biological fact so when you turn down
insulin you will burn fat so a ketogenic
diet you can't produce ketones unless
your insulin is low enough so a ketogen
the ketones on that meter are showing
you that you are burning fat you can't
make ketones unless you're burning fat
so you can't you really cannot burn fat
unless you're in ketosis you don't
necessar have to be in ketosis all the
time you don't necessarily have to have
very high Ketone levels but if you're
not in ketosis you're not burning fat so
um if you're not in ketosis the brain
can't even see that you've got energy
spare energy to burn you might have 200
300 pounds of stored energy as fat the
brain will still ask you to eat to eat
more carbohydrate because it's not in
fat burning mode so it's in car
carbohydrate burning mode when it's
hungry it's going to look for more
carbohydrate you have to you have to
teach it you have to bring your body
into fat burning mode and and train your
body give your cell some time a few
weeks to learn how to burn fat again and
stay there my mother is 91 years old she
has lost 50 pounds on a ketogenic diet
it is never too late to all she has to
do is make sure those there are ketones
on her meter when her glucose meter was
nice and stable she wasn't losing
weight because the insulin was still too
high the ketones tell you the ketones
are essentially a mirror image of your
insulin level so we don't have a home
insulin level test yet we
have fabulous continuous glucose
monitors which I recommend anybody out
there with a mental health issue or
physical anybody out there who can
afford $5 or $50 for a single two week
glucose sensor which are now available
in the United States over the counter
which they weren't before um I think
you've had them in the UK for a lot
longer you can see what your glucose
levels are doing in response to your
lifestyle your food choices your
exercise Etc they can't it can't tell
you what's going on with your insulin
level so you can have a nice beautiful
stable glucose level nice in the healthy
range your insulin can still be too high
and you still might just be you're
burning all that glucose for energy
a ketone meter will tell you if you're
burning fat I'm on Amazon now it says
sort of $50 or yeah there's ones for $40
as well yeah one for $30 as well yeah
interesting okay think I'm going to try
one I've never actually done one before
so I I guess I didn't really know if I
was in ktis ketosis or not but I just oh
it's so useful because um uh if you're
if you're following a ketogenic diet um
the thing that makes it ketogenic is the
ketones yeah and so I you were telling
me before before we started recording
that um you're always looking up okay
which foods are keto which foods aren't
keto and it's really not so much about
that you could eat almost anything on a
ketogenic diet if you if you understand
you know how much to have and when um
and but uh uh in any case um the Ketone
meter will tell you you're in ketosis
and if you're not in ketosis you can
tweak your your plant so all of this is
in the book but um but you can the
really the the most important thing
about a ketogenic diet is getting into
good consistent daily ketosis for at
least six weeks
straight that sends the daily signal to
your cells we're burning fat now we're
burning fat now we need to learn how to
burn fat there are enzyme systems and
Pathways and cells that need to ramp
up and and that takes time so it takes a
while for the body and brain to kind of
learn how to burn fat again and uh it
doesn't happen
overnight in terms of energy there are
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online what part of your work sort of
overlays with psychology you know when
someone comes to you and they they're
experiencing some anxiety or depression
or something and they they're describing
their life and their life is full of
trauma and hard things and they got
fired from their job it seems a little
bit peculiar to talk to them about diet
in that moment it seems peculiar
did do you ever think first about like
some kind of psychological
prescription oh you know I got some my
training at Cambridge hospital uh in
psychiatric residency is very
Psychotherapy focused I got really
excellent training in Psychotherapy and
I still use it every day in my work it
we're not throwing the baby out with the
bath water here in fact the psychology
of people's relationship with food is
really important to address I mean most
of what I do I mean I could I could
teach you in an hour um everything you
needed to know about why you should
switch to a ketogenic diet for mental
health and and I could give you a little
sheet and you could go off and do it
right I would I would be rapidly
obsolete um which would be a good
problem to have right um but what
actually is happening most of the work
I'm doing is not about here's the
science here's why you need to do it
here's what's happening in your brain
here's the food list it would be so easy
if that's what it were we are human
beings and we have really complicated
relationships with food we have history
with food we have spiritual attachments
to food cultural attachments to food
political ATT beliefs about food and and
a lot of us have addictions and
attachments to food that go back a long
way so most of it is about helping
people understand and and sort of hold
their hand through that proc process of
making that behavior change and it's and
whatever is going on in their life is
also important so how did you approach
that with your patients so in the first
in the first interview with somebody I
usually take 90 minutes to two hours
when I'm first uh working with a patient
and I might do that two or three times
before we actually begin uh discussing
what to do with diet because I really
want to
understand um all of the different
pieces of the puzzle not just oh what
are you eating here's what you should
eat M that doesn't work for most people
and because there are going to be
challenges that come up and if the
better I know that person the better I
can help them through those challenges
so it's not it's definitely not um it's
not like I hand them a prescription for
a diet and send them out the door I love
understanding where people are coming
from they're you know the the challenges
they're facing in their lives and how
that all intersects with their metabolic
Health their their exercise you know why
are they not exercising um how is their
sleep how are their relationships who in
their life is supportive of them
changing their diet um is who in their
life is skeptical and worried and
because that could be a major factor for
people if one person in the family wants
or needs to go on a ketogenic diet for
mental health and nobody else in the
family thinks it's a good idea
that's really tough for people you
you've got to plan for all of that and
talk it through say okay here are the
roadblocks we might face how are we
going to how are we're going to deal
with these when they come up so I could
give many many examples but the
Psychotherapy the psychology of it is
why using ketogenic diets to treat
mental health conditions is usually best
done as a
team ideally if you can a keto dietician
or nutrition therapist who's very
skilled skill at using ketogenic diets
designing them and personalizing for
whatever you like to eat um so you'll
have an enjoyable diverse diet that
meets your needs and your desires um so
you won't get bored and you'll enjoy the
food you're eating um and a prescriber
if you're especially if you're taking
medication or have any mental or
physical health issues you'll need a
prescribing professional primary care
doctor um or a psychiatrist or both
depending what's going on for you to
manage the medications and help you
through that transition period where
there are so many different things
changing in your physiology that can
sometimes be uncomfortable if you don't
plan properly um and set the person up
for Success um and a coach a therapist a
psychologist or a coach to for
motivation and support and it could be a
cheerleader but also to reflect back to
you how things are going and and and
keep you moving forward because the
first few weeks are the hardest and once
you get past about week three week three
is a real turning point for a lot of
people your cells just kind of settle in
to a new way of operating and it's this
very noticeable shift that takes place
in people's bodies and brains and that
many people have never experienced
before as it relates to anxiety um what
does the research say about the role
that keto can play in reducing someone's
anxiety yes so anxiety uh if you talk to
any practitioner who has been using
ketogenic diets in their work um whether
it's a a psychiatric practitioner or a
medical practitioner there are a couple
of things they'll tell you that are most
U the most predictable benefits of a
ketogenic diet one is reduced anxiety
and the other is mental Clarity so most
people will experience tremendous
reductions in anxiety um Within often
within three days to three weeks of
starting a ketogenic diet and the mental
Clarity is is one of those things that
you hear almost from almost everybody so
the anxiety is uh remember we're talking
about this roller coaster those stress
hormones are on a roller coaster life
can cause stress and stress can
unbalance your your Chemistry there's no
question about that but your food can
also do that your diet can also
unbalance your stress hormones so and
this is comes back to your question
about you know life stressors you don't
want to ignore those because they still
count and they're still affecting your
metabolic Health stress raises your
cortisol levels and cortisol levels are
dangerous for long-term brain health
High cortisol levels most mental health
conditions come along with disregulated
or poor regulation of cortisol levels in
the brain and too much cortisol can over
time damage the brain including uh the
hippocampus which is the brain's
learning and memory Center so Str add
whether it's coming from inside the body
from the foods you're eating or outside
the body from your life both of those
need to be addressed not just the
dietary stress there's some studies that
I just found um a 2023 systemic review
examine the E efficacy of low
carbohydrate ketogenic diets and
treating mood and anxiety disorders the
review highlighted potential benefits
but emphasized the ne necessity for
randomized control trials to establish
definitive conclusions that was the
Cambridge University press and slightly
separate to that um on serious mental
illnesses I think you talk about this in
your work as well a 2024 pilot study
conducted by Stanford medicine
investigated the effects of a ketogenic
diet on participants with schizophrenia
and bipolar and participants reported
improvements in energy sleep mood and
quality of life suggesting that
ketogenic diet May stabilize brain
functions in serious mental illnesses as
well really really fascinating really
fascinating I never really thought about
the ketogenic diet's impact on my mental
health I used to think I be honest the
reason I do it is um helps me become
more focused
it changes my body composition and
really at the end of the year for me or
at the start of the year it's a nice way
to kind of reset that's the kind of how
I see it I want to come into the year
feeling good and strong and focused so I
do it over sort of Christmas New Year
January time every year with my partner
um but I never really considered the
downstream consequences things like
mental health and those other things but
it it makes sense we have a closing
tradition on this podcast where the last
guest leaves a question for the next
guest not knowing who they're leaving it
for
and the question that's been left for
you is what would you say to someone who
wanted to have less regret and more
contentment and peace on their
deathbed I'm trying to think about what
for myself personally what I would have
regretted
um you know you might want me to say
that I would have regretted not having
written this book and that's true but
honestly it's about finding a really
good healthy relationship in your life I
mean if I hadn't accomplished that in my
life I would have more regrets than not
writing this
book Thank you thank you for writing
this book because it's such a
comprehensive analysis of this poorly
understood link between the things we
put in our mouth and the impact it has
on our mind holistically and I don't
think enough people especially if we
think back decades even thought to
really uncover this sort of link I never
I think before even starting this
podcast never really understood the
concept of metabolic and metabolic
Psychiatry and that there was an
association between the two the great
thing about your book is that you don't
need to be a scientist to understand it
it's clearly written for people like me
who are don't have a profound knowledge
of Science and um medicine and
Psychiatry but are able to learn in
advance the decisions we make just by
reading your book it has been such a
Smash Hit for so many people I was
looking at some of the reviews earlier
on and people really really love it you
wrote it you published it this year
January January January and uh I highly
recommend anyone that is intrigued by
any of the subject matters that we spoke
about today to go and get a copy I'll
link it below um and it has some
extraordinary people on the back who
some of which I've interviewed at least
one of which I've interviewed um in
Jason um is there anything else you
wanted to say about who this book is for
yeah I mean I really want people with
mental health conditions even if they
think they've tried everything if you
know if you're willing to try one more
thing hope is on the menu a powerful
plan to improve mood overcome anxiety
and protect memory for a lifetime of
optimal mental health thank you so much
for the work that you do thank you very
much Stephen for your
work do you know that 80% of New Year's
resolutions fail by February it's
because we focus too much on the end
goal and we forget the small daily
actions that actually move us forward
those actions that are easy to do are
also easy not to do in life it's easy to
save a dollar so it's also easy not to
making one small Improvement each day
one tiny step in the right direction has
a big difference over time and that is
the 1% mindset which is why we created
the 1% diary a 90day journal designed to
help you stay consistent and focus on
the small wins and make real progress
over time it also gives you access to
the 1% community a space where you can
stay accountable motivated inspired
along with many others on the same
Journey we launched the 1% diary in
November and it sold out so now we're
doing a second drop join the wait list
at theed diary.com and you'll be the
first to know as soon as it's back in
stock I'll put the link below
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oh
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Ask follow-up questions or revisit key timestamps.
Dr. Georgia Ede discusses the emerging field of metabolic psychiatry, which focuses on how diet affects brain function and mental health. She explains that the ketogenic diet can act as a powerful tool to stabilize brain chemistry by reducing inflammation, oxidative stress, and insulin resistance, often leading to improvements in conditions like anxiety, depression, and schizophrenia. Ede emphasizes that nutrition is not just about what to add, but also about subtracting harmful, processed foods, and she outlines fundamental principles to nourish, protect, and energize the brain. She also addresses common misconceptions about diet, the importance of personalization based on individual metabolic health, and the need for support when making significant lifestyle changes.
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