There is something that some of your

listeners may have never heard of which

is accelerated TMS. TMS stands for

transcranial magnetic stimulation. It's

a type of brain stimulation

that has existed for decades. But the

hardware and the software, everything

about these technologies has improved

dramatically in the last 5 to 10 years,

particularly in I would say the last 5

years thanks to certain researchers like

Nolan Williams out of Stanford who sadly

passed away in the last 6 months and

others. But what accelerated TMS looks

like is typically up to, let's just call

it maybe one or two years ago.

Accelerated TMS takes

what you might do in conventional TMS

over several months where you go in and

you you have this paddle put against

your head. It produces a magnetic field

that just to keep it very simple either

uh excites or inhibits certain parts of

your brain, certain types of circuitry

and that can be applied to depression,

it can be applied to neurodeenerative

diseases. In fact, in some cases it can

be applied to anxiety, OCD and so on

depending on the target where where you

place these coils.

And in the case of accelerated TMS,

you're taking what you might do over 3 4

5 months and you're compressing it into

one week. So every hour on the hour, 10

hours a day for one week, you're going

in and getting, let's just call it a few

minutes, 3 to 9 minutes of pulses on

your brain. And then you take 50 minutes

off, you go back in, you get hit again.

>> [snorts]

>> And that has been referred to at least

in one format, the Saint protocol, S A I

N T. They've shied away from it, but it

was developed at Stanford. And the Saint

protocol in many, let's call them

patients produces

70 80% remission of depression that is

quite durable. It's not one shot, you're

done. Typically, people will, let's just

say, do a 5day sequence. Then they might

go in and have one to three-day booster

sequences 3 months, 6 months later. Um,

and

this technology has tremendous effects.

I've experimented with this over the

last handful of years, and the first

time I did it, it had near miraculous

results. I had I went from having

severe and I've been officially

diagnosed, so this is not uh just

throwing it around loosely, but you

know, moderate severe OCD with lots of

rumination. I'm not flipping light

switches or washing my hands, but I have

these ruminative loops that I get caught

in. People, I'm sure some listening can

identify with this where you just can't

turn off these kind of compulsive

thought loops. Could be a grudge, could

be a fear, could be something you're

planning for, could be a conversation

you need to have. It just loops and

loops and loops, which causes insomnia,

which causes

uh fatigue and just general

uh the general wearing down of the

system, which leads to depression.

That's I've realized that's my sequence.

It actually starts with anxiety, not

depression out of the gate. And I was

having, let's just call it seven, eight

out of 10 symptoms when I went in to the

first treatment I did of 5 days. That's

really severe for people who are

not clear. Like it's really, really

severe. Like it's affecting every aspect

of my life. Had the treatment. There was

a delayed onset. And even the scientists

most involved with this don't really

have a great explanation for how or why

this would happen. But nothing really

happened for 2, three weeks.

[clears throat] and then

flipped a switch and had basically zero

anxiety, zero rumination for let's call

it 3 to 4 months. I've never experienced

anything like it and that includes

psychedelic assisted therapies which I

know very well and have supported a lot

of science u underlying.

Now this is a bit of a long answer I

realize but for people who are

interested I really recommend the

conversation I did with Nolan Williams.

Then there are different types of

hardware. But I tried it then with

boosters several times afterwards. Null

effect. Zero. Didn't work.

>> And I started to

lose hope again because I thought this

was going to be a replicable,

reliable tool that I could use. I was so

excited.

And then I did a hailmary kind of last

ditch

round with the accelerated TMS recently.

I did this in Northern California. And

instead of doing 5 days, so keep in mind

it's like, let's just call it 3 months

of TMS gets compressed into 5 days.

Instead of doing five days, I did one

day, but I predosed with something

called descloer.

And descerion

or DCS as it's sometimes referred to in

the literature is a in many ways an

antiquated antibiotic that used to be

used for tuberculosis

uh and sometimes urinary tract

infections which affects the NMDA

receptors in such a way. I think it's a

partial antagonist. It might be an

agonist so don't quote me on it. But the

the point is this this little drug that

is not typically used anymore

is a catalyst for neuroplasticity.

And when you take this beforehand,

you can do something like one day of

accelerated TMS. And sometimes the

results are better than what you

previously, let's just call it seven

years ago, would get from 3, four

months. And I did one day and Dan

this time around boom it was just like a

switch basically the next day and it has

now been 2 or 3 months and I don't want

to set expectations that it'll be this

way for everyone. It seems to be

particularly effective

yes for depression but it seems to be

particularly effective in a very small

sample size at this point for anxiety

and OCD. uh and

man it's just it's just a different

life. It is a different life. So all of

those things in combination plus the

basics right the kind of basic

macronutrients of health exercise

etc etc etc diet and so on um are just

are just doing their job together. The

last one I'll throw in and then I'll

shut up because I realize this has

turned into a TED talk is um

intermittent ketosis. So, the ketogenic

diet and ketosis overall, which can be

achieved a few different ways, which I'm

in right now, is absolutely phenomenal

for addressing a lot of psychiatric

pains, psycho emotional pains that are

failing to be treated by medication. And

there's something called metabolic

psychiatry. Chris Palmer out of Harvard

and other have have looked at this very

closely. All right. Thanks for coming to

my TED talk.

>> I just want to assure you TED talks are

welcome here. Yeah, you're a podcaster,

you know. Uh [laughter] um long answers

are fine. Um so please delete that sheep

sheepishness from from your mind. Um

>> all right, we'll do

>> I have a million follow-up questions.

Let me just say just high level,

a different life. Those three words

really

>> I just makes me very happy to hear that.

>> Thank you.

>> What's going on?

>> Thank you. Thank you, Dan. Yeah, it's it

is impossible, I think, to overstate the

difference between an 8 out of 10 of

nonstop ruminative

monkey mind with a fixation on things

that are anxiety producing to getting to

like a one or two out of 10. Like those

are two different lived experiences.

They are not

>> they they are so far apart from each

other. It's it's really remarkable.