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The LIFE-EXTENSION Doctor: "The ONE thing that's increasing your chance of early-death by 170.8%!"

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The LIFE-EXTENSION Doctor: "The ONE thing that's increasing your chance of early-death by 170.8%!"

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3229 segments

0:00

going from zero activity to just 90

0:03

minutes a week is about a 15 reduction

0:06

in all cause mortality Jesus Christ Dr

0:10

Peter attia world-renowned physician

0:11

doctor for anything performance or

0:14

longevity related he has the secret for

0:16

living a long healthy and happy life

0:18

most people listening to us are going to

0:20

die in cardiovascular disease cancer

0:22

diabetes if we want to really figure out

0:25

a way to live longer we need a totally

0:27

different Playbook how early do some of

0:29

these diseases begin the minute you're

0:31

born but we only really think about the

0:33

risk over a 10-year time Horizon as a 30

0:36

year old you don't get excited about

0:37

exercise in your sleep but there's a 400

0:40

percent higher risk of dying in the

0:42

coming year when you compare the fittest

0:45

two and a half percent to someone at the

0:47

bottom 25 in the coming year and then

0:50

once you hit the age of 65 if you fall

0:52

and you break your hip there's a 15 to

0:54

30 percent chance you will be dead

0:56

within the next 12 months really you

0:59

have to realize is you're taking this

1:01

for granted when you talk about the

1:04

deterioration of Health you have these

1:05

three categories emotional health

1:06

deterioration why have you included that

1:08

because despite being very physically

1:10

healthy I was not living a good life I

1:12

was in such an awful cycle of anger

1:14

workaholism that I don't think my

1:17

marriage would have survived I realized

1:19

I don't want to be this person and lose

1:21

my kids I don't think I could have

1:23

survived it and I'm sure many people

1:25

listening to us can relate were you able

1:27

to discover the root cause of that more

1:28

than that I was able to get rid of it

1:30

how so what you really need to do is

1:34

what are the biggest misconceptions in

1:35

your mind about weight loss I have

1:37

thought a lot about this so

1:42

Dr Peter attia he is the man that wrote

1:46

the book on how to live a long happy and

1:51

healthy life and he argues that

1:54

everything we know about health and what

1:56

that actually means health of the Mind

1:59

the body and the emotions is wrong and

2:02

outdated

2:04

he says that there's disease growing in

2:07

you and me right now

2:10

but the problem is

2:12

because we can't see it we're doing

2:15

nothing about it Dr Peter's work turns

2:19

the light on

2:21

it allows you to see

2:23

that in many cases

2:26

in action now will increase your chance

2:28

of disease and a much shorter Life by 70

2:32

percent

2:33

170 percent and in some cases if we

2:37

don't take action Now by 400 percent

2:41

I've had lots of conversations on this

2:43

podcast about health about diet about

2:45

all of these things

2:47

but for many of you

2:49

this one will be the one that changes

2:52

your life this will be the one that

2:54

makes you ask some difficult but

2:55

important questions about your health

2:59

and what health means for you I walked

3:02

away from this conversation realizing

3:04

that if I don't take action now

3:07

I'm going to be forced to take action

3:10

then

3:11

and I can unequivocally say that this

3:14

conversation has changed my life

3:17

I have a suspicion it's going to change

3:19

yours

3:19

[Music]

3:23

Peter

3:25

[Music]

3:29

Dr Peter

3:31

you talk about so much in your work I've

3:33

been through every interview you've done

3:35

your book other conversations you've had

3:39

you talk about a lot so many things that

3:41

I'm absolutely fascinated by

3:44

my first question for you is

3:46

what is your mission and why are you

3:49

doing this I think that

3:52

um there is no

3:54

greater

3:56

um desire for people than to be healthy

4:02

especially when you consider how we can

4:04

define health more broadly than just

4:06

physical health wins you can include

4:07

kind of emotional health

4:09

it's kind of the great equalizer and

4:11

nothing else really matters if you don't

4:13

have it right so it doesn't really

4:16

matter if you're famous or not famous it

4:19

doesn't matter if you're rich or poor if

4:22

if your health is compromised and

4:24

anybody who's been through an illness

4:25

where their health has been compromised

4:27

I think we'll realize in a moment

4:30

what they've taken for granted and I

4:32

I've just become personally endlessly

4:35

fascinated by this topic and

4:38

in my own

4:39

quest to understand this better and

4:41

better

4:42

the next natural step was to begin to do

4:44

it as a doctor right to begin to kind of

4:46

help patients with this

4:48

and at some point

4:50

you can only treat so many people and so

4:54

podcasting and ultimately writing a book

4:56

just became a way to put as much of that

4:59

information as possible out there for

5:01

more and more people to access

5:03

do you know why U of old people became

5:05

fascinated by this was there a stuff

5:07

dominoes that fell I think so yeah I

5:09

mean I think

5:10

um

5:11

you know I'd always been interested in

5:13

performance

5:15

um because I'd always you know at least

5:16

as as far back as you know being 12 or

5:19

13 years old

5:21

you know I'd always been obsessed with

5:23

one form or another of some sort of

5:25

physical Obsession whether it be you

5:28

know boxing when I was really young or

5:30

Marathon swimming later in life

5:32

but when my daughter was born when I was

5:35

35 that

5:37

was the first time that everything kind

5:39

of pivoted and I had a little bit of a

5:43

glimpse into the future I would say and

5:44

I just sort of realized oh you know

5:47

the The Joy I'm experiencing In This

5:50

Moment is so

5:52

surprising to me so unanticipated and

5:56

I really want to be able to experience

5:58

this again

6:01

means not just with other children of

6:03

mine but potentially with grandchildren

6:06

and on top of that I had a bit of a

6:08

wake-up call which was I realized that

6:10

all the men in my family died

6:12

prematurely of heart disease obviously I

6:14

knew that fact before this time but I

6:16

think it was the Confluence of those two

6:18

things it was the realization that yeah

6:20

you know if you don't figure something

6:23

out and do something about this you're

6:24

probably going to die of heart disease

6:25

in your 60s which is not that far from

6:27

now you know 25 30 years from now and

6:30

you now really have a motivation to live

6:33

longer and to live better longer

6:37

and so that in many ways kind of began

6:40

the change in my direction my focus to

6:43

to being one that was not purely just

6:46

focused on performance anymore but sort

6:48

of focused on understanding Health in a

6:50

different way

6:52

this concept of medicine 3.0 is a

6:54

concept which I only discovered in your

6:57

work never had the time used before

6:59

um

7:00

what is medicine 3.0 and how did you get

7:03

to the point when you realized that

7:04

there needed to be an iteration on the

7:06

current system of Medicine

7:09

yeah the reason I think you hadn't heard

7:11

of it before is I don't think it's been

7:12

described before so you can't be faulted

7:14

for that

7:16

um but as I began writing the book and

7:20

thinking about how

7:22

I was practicing and how people like me

7:25

practice

7:27

I realized that it is a very distinct

7:29

change from the current form of Medicine

7:32

and in a way to not be just critical of

7:36

the current form of medicine I had to

7:37

put it in the context of what existed

7:39

even before that and that's how I sort

7:42

of realized well we're in this version

7:44

of medicine called medicine 2.0 but it's

7:47

following something called medicine 1.0

7:48

and it's an enormous Improvement above

7:51

that so maybe I can spend a moment just

7:53

kind of explaining what those three are

7:54

and I think that's probably the easiest

7:56

way to explain the current form so

7:59

um

8:00

medicine 1.0 is everything that existed

8:02

before we really understood the science

8:05

of Medicine

8:06

so for most of human history we had no

8:10

idea why people got sick or why people

8:13

died or what an infection meant and we

8:17

sort of thought that these were plagues

8:18

from the gods or things of that nature

8:21

but a couple of things happened in the

8:24

past

8:25

you know 100 few hundred years the first

8:28

was the idea of a scientific method

8:31

something that we take for granted today

8:33

where you can make an observation about

8:35

something in the world formulate a guess

8:37

called a hypothesis about why it's

8:39

happening and then design an experiment

8:41

to test it that's called the scientific

8:43

method

8:44

that's an invention that's a creation we

8:47

had to figure that out

8:48

also things like a light microscope

8:51

which you know up until 140 years ago or

8:54

so didn't exist allowed scientists and

8:56

doctors to be able to actually see these

8:58

microscopic things called bacteria and

9:01

then ultimately the development of

9:02

things like antibiotics and eventually

9:04

vaccines all of these things made an

9:06

enormous difference in reducing the

9:10

suffering and death due to what I call

9:13

in the book Fast death

9:14

so fast death is pretty much how we used

9:16

to all die

9:18

fast death would be trauma and infection

9:21

and up until

9:24

about 150 years ago life expectancy

9:27

would have been high 30s low 40s and

9:31

most of us succumbed to fast death

9:34

but with the Advent of medicine 2.0

9:37

through all those transitions I just

9:39

described

9:40

in the span of a few Generations we've

9:43

doubled life expectancy right so now

9:45

life expectancy is roughly twice what I

9:47

just said a minute ago

9:48

and most people do not die from Fast

9:51

death

9:52

but it's been supplanted by slow death

9:54

today most people listening to us are

9:57

going to die from cardiovascular disease

10:00

from cancer Dementia or other

10:02

neurodegenerative diseases complications

10:05

of diabetes

10:06

and on the one hand that's a sign of

10:10

progress it means like Hey we're living

10:11

long enough to die from those things but

10:14

we've made scant progress against those

10:18

things

10:18

in fact if you go back and

10:22

strip out the top eight causes of

10:26

infectious death or communicable death

10:29

death from communicable diseases or

10:30

infectious diseases today if you strip

10:32

them out our life expectancy is not much

10:35

better than it was in the 1800s

10:38

in other words that doubling of life

10:40

expectancy that we've experienced comes

10:43

almost exclusively to the reduction of

10:46

those fast deaths and has little to do

10:48

with any success we've had against slow

10:51

death

10:52

if we want to really figure out a way to

10:54

live longer and I would argue more

10:56

importantly live better meaning when

10:58

we're in the last Decades of our life

10:59

not be in a state of total decline we

11:01

need a totally different Playbook

11:04

and that Playbook is medicine 3.0 and it

11:06

involves real prevention so that means

11:09

taking True step steps at prevention

11:12

very early in life

11:14

it also involves being very personalized

11:16

in how you do things so it means you

11:18

can't just do paint by numbers you can't

11:20

just sort of say the same thing to

11:21

everybody

11:22

clearly there are certain things that

11:25

make absolute sense across the board

11:27

such as sleep and exercise you know but

11:31

the way you might use medications is

11:33

going to have to be much more tailored

11:34

to an individual

11:36

you say that there are there are four

11:37

points to Medicine 3.0 which is the

11:40

prevention the being unique in your

11:42

treatment

11:44

um to each individual an honest

11:45

assessment and acceptance of risk yeah

11:49

one of the things that I don't think we

11:52

think enough about as doctors sometimes

11:54

is is risk right now I think doctors are

11:57

very good at thinking about the risk of

11:59

doing something yeah

12:01

um I think you know usually a doctor is

12:02

pretty good at understanding you know if

12:04

you have this surgical procedure there's

12:06

a risk of an infection there's a risk of

12:08

bleeding there's a risk of all these

12:10

things if you take this medicine there's

12:12

a risk of this side effect or that side

12:13

effect

12:15

but I don't think we spend enough time

12:16

thinking about the risk of not acting or

12:18

the risk of not acting when we do

12:21

so this is where I think it gets a bit

12:23

more nuanced

12:26

um

12:27

prevention doesn't come without risk

12:30

right I mean you're still going to have

12:32

to do something in in the state of

12:34

prevention

12:36

um so the question is understanding the

12:39

time Horizon upon which you're

12:42

considering risk

12:43

so I'll give you one very specific

12:45

example

12:47

um

12:48

at least in the U.S and it might be the

12:50

same in the UK

12:51

um

12:52

we only really think about the risk of

12:55

heart disease over a 10-year time

12:57

Horizon so look at someone like you

13:00

you're 30 years old right so

13:02

what is your 10-year risk of having a

13:06

heart attack

13:07

I can tell you without knowing anything

13:09

about you it's really low good it's as

13:13

close to zero as we could have in

13:15

medicine

13:17

but what if I did a blood test on you

13:19

and I found biomarkers in there that

13:23

were predictive of very high risk later

13:25

in life

13:27

now that would be actually quite

13:28

possible there's there's about a one in

13:31

ten chance you might have a biomarker

13:33

called LP little a for example which is

13:36

just a certain lipid in your body about

13:39

a one in ten chance you have that

13:41

dramatically increases your risk of

13:42

cardiovascular disease my uncle died

13:45

very early I believe in his 50s of a

13:47

cardiovascular disease interesting

13:50

so knowing that by the way could be

13:52

helpful because that would prompt me to

13:53

ask you more questions and want to know

13:55

more about all the people in your family

13:57

so here we have a 1 in 10 chance and by

14:00

the way we wouldn't leave it to chance

14:02

we would just check it and we let's say

14:03

we checked your level and you had that

14:05

you had that lipoprotein or you had an

14:07

elevated level of another lipoprotein

14:08

APO lipoprotein little B and again these

14:11

are kind of technical terms but they're

14:12

very common things and they're easy to

14:14

measure

14:16

the medicine 2.0 view here would be well

14:19

there's nothing wrong with you now and

14:21

there's not going to be anything wrong

14:23

with you for the next 10 years

14:25

we don't need to do anything about it

14:28

conversely if I take a lifetime view of

14:32

risk I would say

14:34

yeah but the risk to something happening

14:36

in the next 40 years is actually quite

14:39

significant

14:40

so my risk of doing nothing is probably

14:43

much higher than my risk of doing

14:45

something today so my risk of doing

14:47

something today would be non-zero but

14:49

small but my risk of doing nothing if I

14:52

take the appropriate time Horizon is

14:54

much bigger this is one of the things in

14:56

your book that really really got me

14:57

thinking was I have to say and I believe

15:00

a lot of people probably feel the same

15:01

way I've gone through my life thinking

15:04

to some degree I'll worry about avoiding

15:07

these diseases later I'll I'll when I

15:11

get to 45 then I'll start taking this

15:13

thing seriously because then I'm getting

15:16

into that territory where most people I

15:17

know that get cancer or Alzheimer's or

15:19

all of these cardiovascular things

15:21

that's when it tends to happen so I'll

15:23

think about it then

15:25

totally understandable

15:28

um and I'll frame this in the context of

15:31

a question I get asked all the time

15:33

which is hey Peter when is the best time

15:36

to start thinking about this stuff

15:39

and I say look I can't answer that

15:41

because there are two competing issues

15:44

that are crossing

15:47

when I meet somebody who's in the last

15:49

decade of their life

15:51

do you know how much they are thinking

15:52

about this like it's all they're

15:55

thinking about

15:56

it's all they're thinking about every

15:58

minute of every day is a confrontation

16:01

with their own mortality

16:03

the problem is

16:06

they don't have much time

16:09

to change the direction of the ship you

16:12

may recall in the book I write the sort

16:13

of I use the metaphor of the Titanic

16:16

right

16:17

it's not that the Titanic didn't see the

16:19

iceberg it's that it didn't see the

16:21

iceberg in time it didn't have enough

16:24

Runway to really move out of the way and

16:26

that's why the Titanic gashed the side

16:28

of the boat

16:29

now at the other end of the spectrum a

16:32

30 year old like you has unbelievable

16:36

potential to change the Arc of your life

16:40

you have so much runway to

16:45

through manipulating nutrition and

16:47

exercise and sleep and stress and all of

16:49

these things to completely alter the to

16:52

the disease trajectory of your life

16:54

the problem is and I'm not just speaking

16:56

to you personally but more broadly to

16:58

someone who's as young as you it's

17:01

harder to find the motivation because

17:03

there are no reminders of your own

17:05

mortality you're Superman

17:07

right the worst thing that happens to

17:10

you is a hangover so I always get asked

17:12

like when is the right time to start

17:14

worrying about this and the short answer

17:16

is look as soon as possible but then

17:18

there's a reality that says for most

17:21

people it's not until they're in their

17:22

40s

17:24

maybe once they have kids that they

17:27

start to appreciate their own mortality

17:28

and that that provides some of the

17:30

motivation

17:31

to say you know

17:33

maybe I'll be a little less focused on

17:35

optimizing everything for today

17:37

and I'll start thinking a little bit

17:39

about tomorrow so again another way to

17:40

think about this is saving for

17:41

retirement

17:42

a lot of people in their 20s and 30s who

17:45

are making good money aren't necessarily

17:48

taking the most prudent Financial steps

17:50

to ensure Financial Freedom when they're

17:53

in their 70s

17:55

because let's be honest it's more

17:58

enjoyable to spend money today than to

18:00

set some of it aside

18:02

but there are a lot of people later in

18:04

life who think I wish I was a little bit

18:06

more responsible earlier on how early do

18:09

some of these disease if you looked at

18:11

my sort of metabolic health or if you

18:12

were able to look inside my body which

18:14

I'm sure you're able to do how early do

18:16

some of these diseases begin

18:19

in my in my life at what age do you see

18:21

some of these things coming yeah it's

18:23

super interesting because

18:25

there are some elements of you as a

18:29

person that are going downhill the

18:32

minute you're born

18:33

and there are others that are not so

18:35

let's let's use two examples

18:37

let's start with something where your

18:40

body is getting better and better and

18:44

um you know you're probably only peaking

18:46

now but you haven't really started to

18:49

age

18:51

um your muscle quality okay so when you

18:55

were five years old

18:56

your muscle quality was nothing like it

18:58

is today

18:59

but as you enter your 20s the quality of

19:04

those muscle fibers these type two one

19:06

these type 1 and type 2 muscle fibers so

19:08

these are kind of slow to fatigue but

19:11

high endurance fibers are the type one

19:13

fibers the type two fibers are very very

19:15

powerful but they're kind of quick to

19:18

fatigue the quality of both of those

19:20

fibers is very high and the more you

19:23

train them the higher quality they will

19:25

be

19:26

but as you enter your 30s you will now

19:29

start to experience a shrinkage of those

19:32

type 2 muscle fibers you will be less

19:35

powerful in your 30s in your late 30s

19:38

especially than you were in your mid to

19:40

late 20s so that's a form of Aging you

19:43

are declining it's not an accident that

19:46

the most powerful athletes in the world

19:48

are at their peak in their late 20s and

19:50

early 30s so sprinters for example

19:52

that's a prime example of a pure pure

19:55

Power Sport

19:57

um

19:59

we look at other things like more of

20:01

your muscular endurance that will Peak

20:02

even a little bit later you can keep

20:04

that going a little bit later

20:06

we look at certain forms of cognition so

20:09

if we look at something called fluid

20:11

intelligence right this is raw

20:13

horsepower processing speed you have

20:16

more of it right now than I do meaning

20:19

you're going to have faster processing

20:21

speed better memory all of these things

20:24

are going to be better when you're 30

20:26

than at my age I'm 50. because that's

20:29

already started to decline in me

20:31

there are some things however that began

20:33

Aging in you the minute you were born

20:35

and one of them is actually going back

20:37

to this idea of atherosclerosis or

20:39

cardiovascular disease well that's an

20:42

example of a disease process that begins

20:44

right away at Birth and even though it

20:47

almost never rears its head as far as

20:50

death before you're 50 make no mistake

20:53

about it it's starting on day one

20:55

and we know this by the way because when

20:58

we look at studies of people who die for

21:01

completely unrelated reasons so somebody

21:03

who you know dies in a car accident or

21:06

soldiers dying in war and we look at

21:08

their the arteries of their heart we

21:11

already see quite Advanced disease so

21:14

the truth of it is you already have

21:17

pretty significant disease in your

21:19

coronary arteries it hasn't risen to the

21:21

level of ever causing a heart attack and

21:24

it's unlikely to do so for another 20

21:26

years maybe even another 30 years but

21:29

it's compounding it is compounding

21:31

exactly and if you want to live to be 90

21:35

free of cardiovascular disease it makes

21:38

a big difference if you can slow it down

21:40

when you're in your 20s and 30s

21:45

interesting

21:46

that's really what I'm trying to change

21:47

in myself is I'm trying to find the

21:49

motivation like you said when we're not

21:50

confronted with our mortality it's

21:52

interesting because my life changed

21:54

because of the pandemic in part because

21:55

I got to see

21:57

um the relationship between

22:00

things like obesity poor metabolic

22:03

health and mortality for the first time

22:07

and that's really when I started working

22:08

out every pretty much every day now it

22:11

was three years ago in

22:13

March 2020 2020 when I was watching the

22:17

TV and it was that confrontation of like

22:19

oh my God the reason why I'm having a

22:21

better outcome with this disease is

22:22

because I'm in better metabolic Health

22:24

metabolic shape and it's funny that it

22:27

has to take those things in our lives

22:28

for us to make the changes quick one

22:31

before we get back to this episode just

22:32

give me 30 seconds of your time

22:34

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22:36

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23:12

the things you love about the show

23:14

thank you thank you so much back to the

23:16

episode when you talk about the

23:18

deterioration of Health you have these

23:19

three categories cognitive decline

23:21

um decline in loss and function of our

23:23

physical body and then emotional health

23:24

deterioration why emotional health

23:26

deterioration

23:27

why why have I included that yeah why

23:30

have you included that well I mean maybe

23:33

I'll just take a step back and say where

23:35

I kind of put these all in perspective

23:36

so

23:37

you know the the title of the book right

23:40

is outlive the science and art of

23:41

longevity and what is longevity well

23:44

longevity is really about two things

23:46

it's about the length of life

23:49

and the word for that is lifespan but

23:53

it's about the quality of life and the

23:55

word for that is Health span and it's

23:58

Health span that has those three

23:59

components you just described Health

24:02

span meaning quality of life is

24:04

determined by your cognitive function so

24:07

what's your processing speed what's your

24:09

executive function what's your memory

24:10

all of these things it's determined by

24:13

your physical health

24:15

how much strength do you have are you

24:17

free from Pain how much endurance do you

24:19

have what what capacity do you have to

24:22

do whatever you want to do physically

24:24

are you Limited in any way by pain

24:26

strength movement balance

24:29

Etc and then the final piece is

24:32

emotional health what's the state of

24:34

your relationships are you do you have

24:36

joy in your life do you have a sense of

24:39

purpose are you happy

24:41

um not all the time right do but do you

24:44

have the capacity to regulate your

24:45

emotions and so now to answer your

24:49

question why would that be included well

24:51

the truth of the matter is it wasn't

24:53

something I always included right it

24:55

wasn't something I necessarily thought

24:57

much about

24:58

until it was I think very starkly

25:01

pointed out to me by a very astute

25:04

therapist who

25:07

in observing my own struggles in life

25:09

said something to the effect of isn't it

25:12

really ironic that you are putting so

25:14

much energy into

25:16

helping people live longer and yet you

25:19

are paying no attention to your own

25:22

misery

25:23

and I think that was you know and that

25:26

was about six years ago and that was

25:28

kind of when I realized I needed to

25:30

rethink my approach to this problem and

25:33

as I write about in the book I think I

25:36

would make the case today that if your

25:39

emotional health is suffering none of

25:42

the others really matter that much

25:44

so what you really need to do is think

25:46

about a way to have all of these things

25:48

in order what does she mean by your own

25:50

misery

25:52

well I mean I think at that point in my

25:54

life I mean

25:55

I there's there's no two ways about it I

25:57

mean I was just incredibly miserable

26:00

incredibly angry

26:02

um despite being very physically healthy

26:04

right despite doing all of the important

26:07

things to be physically healthy right

26:08

exercising uh you know

26:12

in all the right ways eating well

26:14

sleeping well optimizing every aspect of

26:16

my health but but living living a bad

26:20

life

26:21

what were the symptoms of that what were

26:23

the kind of for you to start to spot

26:25

that because sometimes we don't know in

26:26

our own behavior and sometimes it's

26:28

reflected back on from other people

26:30

we'll get feedback from our wife or our

26:33

girlfriend yeah I mean

26:35

Detachment from others

26:38

um

26:39

prone to anger workaholism selfishness

26:44

you know it wasn't it wasn't subtle it

26:46

wasn't like hmm I wonder if you know I'm

26:50

not being my best self no if I if I was

26:52

being honest and confronting it I was

26:54

not I was not living a good life did you

26:56

know that in the moment had I asked you

26:58

in the moment are you happy what would

26:59

you have responded

27:05

I think I would have probably said

27:09

to just that question sure

27:12

right but but I think to a deeper

27:14

prodding

27:16

um

27:17

no and and there were there were a lot

27:20

of things that happened in there but but

27:21

certainly a very powerful one was going

27:26

to the funeral of

27:28

um

27:29

a woman my age who was the mother of my

27:33

daughter's best friend

27:34

so my younger daughter's best friend her

27:37

mom died of cancer and so all the

27:40

parents you know we're at the free we're

27:42

at the funeral

27:43

and at the time I was

27:45

you know

27:47

really going through a lot of difficulty

27:52

um in my own marriage and

27:55

this woman who died was a very

27:57

successful lawyer

28:00

um really pretty remarkable

28:03

and I was

28:05

really sort of struck how at the funeral

28:08

people had the nicest things to say

28:11

about her what a beautiful mother she

28:14

was she had three kids

28:16

and

28:18

nobody talked at all about her career

28:20

like there was not a single word about

28:22

her achievements in life it was only a

28:26

discussion about the quality of her Life

28:31

as a mother

28:32

and that might sound very obvious

28:34

because when was the last time you were

28:36

at a funeral where they talked about

28:38

someone's career accolades

28:40

but that in a moment really fused

28:45

an idea from a book I had just read by a

28:48

guy named David Brooks called the road

28:51

to character

28:52

I don't have you read it

28:54

in the book David Brooks talks about

28:56

this idea of there being

28:59

um resume virtues and eulogy virtues

29:04

and I really understood in that moment

29:06

that my entire life at that moment had

29:10

been only predicated on bolsting my

29:13

resume virtues I had never spent a

29:16

moment thinking about my eulogy virtues

29:19

and at that moment to your question if

29:23

someone had asked me how is your eulogy

29:26

I would have been brutally honest and

29:28

said it is awful

29:30

there is not a single nice thing anybody

29:33

who matters about me in other words of

29:36

the people who should matter most they

29:39

won't be able to say anything nice about

29:40

me

29:44

is that painful to admit

29:46

yes it's painful to admit today and it

29:48

was painful to acknowledge then

29:52

wow I'm so impressed that you're able to

29:57

because I thinking about cognitive

29:59

dissonance and how psychologically

30:01

uncomfortable that must be to face

30:04

you hint in the book about I think it

30:06

was in the last chapter of the book you

30:08

start hinting about

30:09

the origins of that behavior the

30:12

workholism and all of those things and I

30:13

can totally relate I think I'm a total

30:15

workaholic I think I sacrifice too much

30:18

in the pursuit of like accolades

30:19

sometimes in my life everyone knows me

30:21

including these guys will all say that

30:23

about me

30:25

um and I've often tried to in hindsight

30:27

figure out where that came from in me

30:28

and undo that

30:31

it's funny because reading this book the

30:35

last chapter I actually wrote in my

30:37

notes remember I just wrote Because the

30:38

chapters called emotional health I wrote

30:40

brackets trauma and the role that trauma

30:42

plays I didn't expect to find

30:45

that subject matter in this book about

30:48

longevity

30:49

um what's your thoughts on the role

30:50

trauma plays and how we go about

30:52

understanding it so that we can live a

30:56

have a long Health span

31:00

I think there's probably a lot of people

31:02

who can relate to the stuff I write

31:04

about in the Final Chapter and you're

31:06

right that chapter is

31:08

a significant deviation from the first

31:12

16 chapters so there's 17 chapters in

31:15

the book and

31:17

I I basically make the argument that I

31:20

am the doctor for 16 of them the first

31:23

16 I'm talking about this

31:26

as though I'm the doctor you're the

31:27

patient I'm going to help you and this

31:30

is how to do all this stuff and then in

31:32

the Final Chapter I'm saying actually

31:34

now I'm the patient and I'm going to

31:36

kind of walk you through this journey

31:37

I've had and hope that it basically

31:40

motivates each of you to have a similar

31:43

examination of yourselves

31:45

and um

31:48

I I think that many people I can't tell

31:51

you what fraction of people but I think

31:53

many people have maladaptive behaviors

31:56

in their life that are indirectly or

32:00

directly the response to

32:04

something that we would Define as trauma

32:06

and and Trauma is a very vast uh concept

32:09

right I think it's very easy when you

32:11

hear the word trauma to think of abuse

32:14

and you know that can be physical abuse

32:16

sexual abuse spiritual abuse these

32:19

things like that and it's true I did

32:20

experience abuse in my life

32:24

um

32:24

but trauma can be much more than that

32:27

trauma can be abandonment uh enmeshment

32:31

witnessing tragic things so there are

32:34

lots of things that are traumatic I

32:36

discussed them in the book and

32:39

what happens to children who are

32:42

traumatized and it can also happen to

32:44

adults but I think most often the

32:47

formative years of our lives are when

32:49

these things happen

32:51

is we we adapt and I think that's the

32:56

kind of remarkable thing about us is how

32:58

adaptive we are

33:01

and those adaptations

33:04

can often be very positive

33:07

but a lot of times they have negative

33:10

collateral or maladaptive

33:13

consequences in addition

33:16

and some of those adaptations that are

33:19

negative are addictions some of them are

33:22

other maladaptive behaviors like anger

33:24

some of them include you know things

33:27

like codependencies so you can sort of

33:29

look at people and realize that hey you

33:34

know maybe that person who grew up in

33:36

the home of Alcoholics even if

33:38

it was an otherwise reasonably

33:40

well-meaning home and it's not like they

33:42

were getting hit with a belt buckle

33:43

every night but they weren't getting the

33:45

type of attention that they needed

33:47

and their adaptation was to have an

33:50

attachment disorder that wouldn't

33:52

manifest itself really fully until they

33:54

were apparent so

33:56

this this type of analysis really I

34:00

think everybody needs to spend some time

34:02

thinking about it and needs to spend

34:03

some time asking themselves hey which of

34:06

my behaviors are maladaptive and it's

34:09

something that's done and I think it

34:11

needs to be done without judgment this

34:13

isn't about saying I'm a bad person

34:14

because of X Y and Z even though I think

34:17

I can objectively look back at my own

34:19

behaviors at that time in my life and

34:21

say those are awful behaviors I'm not

34:23

proud of those behaviors but it's

34:24

separating the behavior from the self

34:27

it's not saying I'm a horrible human

34:28

it's saying I'm a human who did horrible

34:31

things and I want to understand why I

34:33

love that approach because I think about

34:35

the maladaptive Behavior patterns I had

34:37

that stood in the chance stood stood in

34:39

the way of my chance of emotional health

34:41

and good relationships and a lot of

34:43

those stem back to my childhood and

34:46

um what I witnessed in my home and then

34:47

distort the way that made me adapt and

34:50

the beliefs it gave me about romantic

34:51

relationships for example so I became

34:53

totally avoidant of those until later in

34:56

my life when I realized this pattern

34:59

um the third point in your in your list

35:01

of things that

35:02

cause sort of I guess longevity of one's

35:06

Health span is that emotional health

35:07

deterioration so before we get into the

35:09

other two my question really was on that

35:12

third point of emotional health

35:14

what for you has helped you to

35:18

um self-analyze and become aware and to

35:21

then get those things out of your way

35:23

that stand a chance of

35:25

costing you your emotional health was it

35:27

therapy was it introspection is it

35:29

journaling is it honesty with oneself

35:31

well I mean in my case I think the

35:33

situation was so far gone that I

35:36

actually had to go away

35:37

on two occasions

35:40

um so I I had to go away in uh in it the

35:45

first time for two weeks uh to an

35:48

inpatient like what's called a

35:49

residential care facility which was two

35:52

weeks of

35:54

like 14 straight days of 14 hours a day

35:57

just doing trauma therapy in group and

36:00

individually

36:01

and uh you know two weeks might not

36:04

sound like a long time but boy that was

36:06

about the most

36:08

brutal exhausting thing I'd ever done in

36:11

my life

36:12

and then again

36:15

I had to do it for three weeks at a

36:17

different facility so again 21 days of

36:20

inpatient treatment but also now really

36:22

learning what the tools were to manage

36:25

myself how do I fix that behavior how do

36:30

I how do I manage it so sort of like you

36:33

have an injury you go to rehab you know

36:36

there's an acute healing phase but then

36:38

there's a well now you want to make sure

36:40

you're strong and that you don't injure

36:42

it again because that injury took place

36:44

because of some weakness and and that's

36:47

not not a Perfect Analogy but the point

36:49

is you know there's a reason that you're

36:52

shoulder separated yeah and we want to

36:54

make sure it doesn't happen again even

36:55

once you're better and you sent yourself

36:57

there twice yes and no I mean truthfully

37:00

I don't think I had a choice I don't

37:02

think my I don't think my marriage would

37:05

have survived so I I think it was

37:08

um

37:10

I'm not sure I had a choice truthfully

37:12

so I went very reluctantly

37:16

I did not want to go

37:18

but it was there was a an ultimatum

37:21

essentially yeah

37:22

wow

37:24

what was the greatest sort of gift that

37:27

process gave you

37:28

oh it gave me my life

37:37

I mean it literally saved my life really

37:40

for sure

37:44

how

37:46

well I don't think

37:52

I don't think I would I just don't think

37:54

I'd be alive today without it right I

37:56

think had I lost I mean I was on such a

37:59

I was on I was in such an awful cycle of

38:02

Shame and self-loathing and

38:04

deterioration that

38:08

I don't think I could have survived it

38:12

so was that that was a narrative in your

38:14

head at the time that you when you talk

38:15

about shame and self-loathing that's

38:17

what the the voice in your head was

38:19

yeah the the voice is

38:22

you are an awful human being that's why

38:25

you behave this way and

38:29

there's nothing that can be done about

38:30

it you you're born this way you you are

38:34

defective

38:36

and this is what defective people do

38:38

look in many ways it's a lack of

38:39

accountability right

38:41

it's sort of saying

38:43

you have no agency in this

38:46

you you can't change this because you

38:48

are you're defective when they do an

38:50

autopsy on you they will see something

38:52

in the temporal lobe of your brain that

38:54

explains your pathology

38:57

were you able to discover the root cause

38:59

of that narrative in your head

39:02

yes absolutely

39:05

and and more than that I was able to get

39:07

rid of it really yeah

39:10

I'll give you one very tangible example

39:12

I had

39:14

a very very vocal inner critic

39:20

um and I think I'm sure many people

39:22

listening to us can relate to that which

39:24

is you know I was such a perfectionist I

39:27

was such a workaholic

39:29

but any mistake I made I would

39:33

eviscerate myself verbally

39:36

so and this was I mean this is mistakes

39:40

that don't matter okay so one of my

39:42

hobbies is archery I love archery so

39:45

every day almost every day certainly if

39:48

I'm not traveling I'm going to be out in

39:50

the backyard shooting my bow and arrow

39:52

now does anybody else care

39:55

nobody right is this my livelihood

39:58

depend on this no

40:01

but if I'm not shooting well

40:03

I am screaming at myself

40:06

I will break an arrow over my thigh and

40:10

these are carbon arrows they'll leave

40:11

welts the size of your finger

40:15

one of the exercises we had to do

40:19

was

40:20

and this was once I left the second

40:23

therapy place that was three weeks

40:25

so the one of the big realizations there

40:28

was that this was happening because that

40:29

voice like I didn't realize that that

40:31

was unusual

40:33

so the exercise was

40:35

every single day until this voice goes

40:39

away

40:40

which I thought would never happen which

40:41

meant I thought I was signing up to do

40:43

this exercise for the rest of my life

40:46

you take out your phone

40:48

and you talk into the phone with a

40:51

replacement voice for that voice

40:53

and pretend you're talking to your

40:57

closest friend as if it were them who

40:59

made the mistake

41:01

and I say

41:03

hey Chris

41:05

I know you're having a bad day today

41:07

I can tell it's hard you're not shooting

41:10

well

41:11

it's okay

41:13

you know what some days it's just not

41:15

going to go well

41:16

plus it is a little windy today let's be

41:18

honest it makes it a bit harder and

41:21

why don't we just pack it up and come

41:23

back and try again tomorrow you know

41:25

just talk in a kind way talk in the way

41:27

you would literally speak to your friend

41:28

and then I would send that recording to

41:31

my therapist

41:32

so every day my therapist is getting

41:34

multiple versions of these voicemails

41:37

but this is important because I'm

41:39

audibly doing this

41:40

multiple times a day

41:43

and

41:45

within about four months

41:48

The Voice just went away really yeah

41:51

let's never come back

41:53

how has it changed you as a father oh my

41:56

God it's a it's a it's a it hasn't

41:58

changed me as a person right as a father

42:00

as a husband as as a boss as a friend I

42:02

mean it's it's just

42:04

um again it makes me a little sad to

42:07

think oh God I wish I knew this when I

42:09

was I wish I wish I did this at 25 you

42:13

know instead of

42:15

all of this

42:17

again I just think of all of the

42:19

collateral damage in my life

42:22

you know all of the people near me who

42:24

have suffered

42:26

unnecessarily as a result of

42:29

you know

42:30

of of of of me being a wrecking ball

42:34

um how much of that could have been

42:35

prevented in some ways this kind of

42:37

comes back to your very first question

42:39

right which is I'm 30 I'm Invincible how

42:42

do I get excited about this look maybe

42:44

the answer is as a 30 year old you don't

42:46

need to get excited about

42:48

you know

42:50

your nutrition and exercise in your

42:52

sleep as much as a 50 year old does but

42:55

a there's a lot of benefit to doing so

42:57

because you'll get more benefit from it

42:58

but maybe it's just focusing on

43:00

emotional health so that you get

43:02

yourself fixed before you start a family

43:04

because I think you know and and I think

43:08

you know I feel lucky I think my kids

43:09

are still young enough I hope that my

43:11

kids don't have too many memories of

43:13

their of their dad in that in that state

43:17

your belief about where that came from

43:19

although there's no evidence there's no

43:21

memory of anyone you know saying well

43:23

this happened and whatever else but

43:25

is your belief that you weren't born

43:28

with that and that something might have

43:29

happened and you've kind of inferred

43:30

that in some way

43:32

yes I think that was a really really

43:34

important breakthrough that happened

43:37

on the 19th day of that second stint I

43:42

had in therapy in that inpatient therapy

43:44

session so that was a 21

43:46

Day program

43:48

that I assumed was only going to be 14

43:51

days and at the end of 14 days they they

43:53

needed me to they wanted me to stay

43:54

another week everybody wanted me to stay

43:56

another seven days and I was so

43:57

reluctant at this point I was exhausted

44:00

I just didn't think I could do it again

44:01

but they were adamant that I stay

44:03

another week and I knew the first time I

44:06

had gone for two weeks and left I left

44:09

kind of against their recommendations

44:11

and I realized I never really got fully

44:15

better I got somewhat better but not

44:16

fully better so I decided

44:18

to just submit to them and say okay fine

44:21

I will stay as long as you tell me to

44:23

and it was on that 19th day that I had

44:27

perhaps the single most important

44:30

Revelation for me again this is very

44:32

personal and

44:33

the point of this is not that everybody

44:36

else is going to relate to this it's

44:37

only that I hope everybody else is

44:39

willing to consider their own version of

44:41

this

44:41

but what I the the last thing I could

44:44

never let go of was

44:47

that

44:50

I was born as a perfect child right like

44:53

meaning we all are right not just me but

44:57

all of these kind of maladaptive

45:00

behaviors were the result of things that

45:04

I didn't deserve

45:06

and

45:09

again it's not all

45:12

what we call Capital T dramas it's not

45:14

it's not necessarily the abuse I mean I

45:17

think in my case perhaps the most

45:19

impactful things of my childhood were

45:22

were more like neglect

45:24

and not not traumatic not like the kind

45:27

of neglect that's gonna that has you you

45:29

should be taken out of a house or

45:30

anything like that I'm just talking

45:32

about not getting a certain type of

45:34

attention

45:35

that I probably should have had

45:38

and for whatever reason that

45:42

manifested itself in really odd

45:44

behaviors that as a kid I just said

45:47

those are just bad behaviors but that's

45:49

just who I was and I think what I

45:52

realized is

45:53

and what I finally came to accept is no

45:56

those are adaptations to something that

45:59

you didn't deserve

46:00

and that might sound like a very subtle

46:01

distinction but it made all the

46:03

difference in the world and it made me

46:05

realize in part by it by looking at my

46:07

own kids that

46:10

you know there is a real innocence to

46:12

children that can very easily get

46:15

injured and and and when it does they're

46:18

going to make sure that they don't get

46:19

hurt again

46:21

and and the way they're going to do that

46:23

is as I said initially in their best

46:26

interest but ultimately it tends to

46:28

result in really negative consequences

46:31

for the way they formulate relationships

46:33

with themselves with for the way they

46:35

form relationships with others for the

46:37

way they're going to parent for the way

46:39

they're going to be a husband or wife

46:42

um

46:43

and so that was that was a huge

46:44

breakthrough

46:47

so important and so powerful and I I

46:49

don't I don't think I've ever said this

46:50

but really thank you for sharing that

46:52

because

46:53

um I got a lot from it and I've had lots

46:55

of conversations about this but I've got

46:57

a lot from that specifically that point

46:58

about

47:00

um didn't deserve for it to happen and

47:02

really it's a response that's trying to

47:04

make sure you don't experience that pain

47:06

again so it's really again it's your

47:08

body is is doing everything in its power

47:09

to help you and to protect you and some

47:11

of these behaviors end up being

47:12

maladaptive which then stand in the way

47:14

of your chance of emotional health

47:16

that is the third category of

47:18

deterioration which is the emotional

47:19

health deterioration

47:21

so let's go a little bit earlier in the

47:23

book and let's talk about the decline

47:24

and the loss of function of our physical

47:27

bodies as well

47:28

um medicine 3.0 as we talked about

47:31

earlier you talk about these five core

47:33

things that help to increase our chances

47:35

of longevity as it relates to our health

47:37

spans what are those five things well

47:39

there's the one we just talked about

47:40

right so all the tools that deal with

47:42

how do you improve your emotional health

47:44

yeah again most of modern medicine only

47:48

thinks about you know if you think about

47:50

where does medicine 2.0 rank on that it

47:53

doesn't really except in the arena of

47:56

mental health right when it comes to

47:58

clinical depression anxiety personality

48:01

disorders you know bipolar disorder

48:03

there we have a branch of medicine

48:04

called Psychiatry that deals with those

48:07

things but outside of that medicine

48:09

doesn't really deal with people like me

48:11

you know I none of my problems quote

48:14

unquote Rose to the level of you know a

48:18

clinical diagnosis that would require

48:20

medical therapy okay tool two exercise

48:24

again we can talk a lot about it if you

48:27

want a little about it but the point is

48:29

it is not remotely given anything beyond

48:32

lip service by medicine 2.0 medicine you

48:35

know if you go to your doctor here at

48:36

the NHS and say okay tell me what my

48:40

workouts should be

48:41

like good luck right how much time

48:43

should I be spending in zone two versus

48:45

zone five like what type of lifting

48:48

should I mean there's no way they're

48:49

going to give you that type of insight

48:51

or specificity uh the third one is

48:54

nutrition again sure every doctor is

48:57

going to tell you eat less exercise more

48:59

but they're not really for the most part

49:02

going to be able to help you manage

49:03

nutrition certainly I didn't learn

49:05

anything about nutrition or exercise

49:07

when I was going through my medical

49:08

training and most Physicians don't so

49:11

I'm not saying that there aren't doctors

49:12

out there who don't understand these

49:13

things what I'm going to say is they had

49:15

to learn that stuff on their own outside

49:17

of their traditional training so crazy

49:20

the fourth one is sleep and that fits in

49:22

the same category

49:23

sleep is an essential pillar of Health

49:25

but we learn nothing about it in our

49:28

medical training in fact most of our

49:30

medical training is paradoxically sleep

49:32

deprived so it's sort of it's a great

49:34

irony the fifth and final thing that you

49:37

have as a tool in the longevity toolkit

49:40

is is all the molecules so drugs hormone

49:43

supplements and there that's the one

49:44

thing you sort of do learn in

49:46

traditional medicine is you you at least

49:48

learn about the the pharmacologic side

49:51

of it you don't really learn anything

49:52

about supplements so most doctors don't

49:54

really understand much about supplements

49:56

and interestingly most doctors don't

49:57

really understand a lot about hormones

49:59

as well

50:00

so medicine 2.0 is is good at what it

50:04

does but it's very limited so it's kind

50:08

of like having a contractor that only

50:09

has one tool instead of five tools and

50:13

as we discussed earlier I think they're

50:14

applying those tools too late in the

50:16

game how can you prove let's start with

50:18

exercise then how can you prove to me

50:19

that exercise is important

50:22

yeah it's a great question so start with

50:25

the easiest way to do this is to look at

50:28

what the absence of exercise does versus

50:32

looking at the absence or presence of

50:35

other known bad things

50:37

now for me to explain this I have to

50:40

explain a technical term called a hazard

50:42

ratio

50:43

so if you'll bear with me while I

50:45

explain what a hazard ratio is it will

50:47

reap lots of fruit later on

50:50

a hazard ratio is a mathematical

50:52

derivation that comes from looking at a

50:58

group of people following them

51:00

prospectively following them into the

51:02

future and looking at the rate at which

51:04

they die

51:06

so a hazard ratio is a number

51:09

if that number is 1.5

51:13

it means that there's a 50 percent

51:15

increase in the risk of death for one

51:18

group versus the other so for example

51:21

if we want to know is smoking bad for

51:25

you

51:25

we might ask the question what is the

51:28

hazard ratio for smokers to non-smokers

51:33

when it comes to getting lung cancer

51:35

okay and the answer is like 10. really

51:39

it's 10 times more about 10 times more

51:42

likely to get lung cancer if you're a

51:44

smoker than if you're a non-smoker

51:46

now if you look at the hazard ratio

51:49

across the course of life

51:52

for all causes of death it's about 1.5

51:55

meaning a smoker is about 50 percent

51:58

more likely to die in any given year

52:01

than a non-smoker which will all cause

52:04

mortality all cause mortality is the

52:06

gold standard for understanding death

52:07

and disease because it takes into

52:09

account every form of death okay okay

52:12

what if you have type 2 diabetes

52:14

everybody understands that having type 2

52:16

diabetes is very problematic and people

52:19

with type 2 diabetes are at about twice

52:22

the risk more or less of cancer heart

52:26

disease maybe one and a half times the

52:28

risk of Alzheimer's disease but when it

52:31

comes to all cause mortality every cause

52:33

of death it's about a 1.4 Hazard ratio

52:36

40 out of 40 percent increase in all

52:39

cause mortality again that's a stark

52:41

number it means at any moment in time if

52:43

you take two people who are ever and

52:45

otherwise always identical but one has

52:47

Type 2 diabetes and one doesn't this

52:49

person has a 40 higher risk of dying in

52:52

the coming year in the coming year yeah

52:54

Jesus Christ yeah wow okay we can keep

52:58

doing this what if it's high blood

52:59

pressure versus normal blood pressure

53:01

that's a hazard ratio of about 1.2

53:04

20 percent same everything I just said

53:06

but it's twenty percent

53:08

okay what if it's someone

53:10

who has end-stage kidney disease their

53:14

kidneys don't work anymore they're on

53:16

dialysis hanging by a thread waiting for

53:18

a kidney transplant

53:20

it's about 2.7

53:23

that's a

53:25

170 percent increase in all cause

53:28

mortality in the subsequent year

53:31

okay

53:32

now let's talk about some other things

53:35

what if I ask the question what happens

53:39

if I take

53:41

a group of 50 year olds pick any age

53:43

pick any sex and we're going to take the

53:46

top

53:47

15 to 20 percent in strength and compare

53:51

them to the bottom 15 to 20 in strength

53:54

for that age and sex what's the

53:56

difference what's the hazard ratio there

53:57

what would your guess be uh

54:02

1.1 to 1.2 yeah yeah it's three two

54:08

hundred percent difference in all cause

54:10

mortality can you make a distinction

54:12

between strength and

54:14

muscle mass okay yep we can do it so

54:17

muscle mass just if we did it just on

54:20

muscle mass it's about two or a 100

54:23

difference so muscle mass turns out to

54:26

be an amazing proxy for strength but

54:28

strength is even better okay yep so high

54:31

strength and high muscle mass produce a

54:34

hazard ratio of about 3.5 okay because

54:36

you can have a lot of muscles but not be

54:38

strong yeah kind of and you can be

54:40

strong and have not as much muscle okay

54:43

and that matters more by the way but but

54:45

they're pretty tightly correlated okay

54:47

yeah now let's look at VO2 max so VO2

54:51

max is the best tool we have to measure

54:55

Peak cardiorespiratory Fitness so this

54:57

is a test that you actually have to take

54:59

it's it's done on a treadmill or on a

55:01

bike they put a mask on your face and

55:03

then the mask measures how much oxygen

55:06

you use

55:07

so in the book I talk in great detail

55:09

about this test it's something anybody

55:10

can do it costs probably 100 quid it's

55:12

not like super expensive

55:15

um and everybody should know their VO2

55:17

max I really think everybody should know

55:18

it and in the book I even offer some

55:20

ways that you can estimate it just by

55:22

running at a track or something like

55:23

that so sorry it's the the measure of

55:26

how much oxygen you're inhaling and

55:28

exhaling no yeah it's the difference

55:30

between how much you inhale and exhale

55:32

is how much you're using so the way that

55:34

the way the test is working is there's a

55:35

little oxygen sensor so if you're

55:37

breathing in we know that the air you're

55:39

breathing in is 21 oxygen we know the

55:42

flow rate and we let's just say you're

55:44

you're blowing it out at 14 so we know

55:47

you used up seven percent times the flow

55:49

rate we figure out how many liters per

55:51

minute of oxygen you're using at the max

55:53

and what's good and what's bad

55:55

yeah so it depends on your age and sex

55:57

but at your age so for a 30 year old

56:00

male we would say

56:03

oh I need the table is in the book

56:06

um really I could estimate it 60 50

56:12

56 would put you in the top two and a

56:14

half percent and that means that I'm oh

56:16

sorry what's that number mean yeah

56:18

that's 56 milliliters of oxygen per

56:21

kilogram of body weight per minute okay

56:23

so

56:29

I think I'm 96 kilograms at the moment

56:32

okay very heavy so you would need to be

56:38

5.3 5.4 5.5 liters yeah no no yeah you

56:43

need to be about 5.5 liters per minute

56:45

you would need to consume 5.5 liters of

56:49

oxygen per minute to come out to about a

56:52

VO2 max of 56 or 57 milliliters of

56:55

oxygen per kilogram per minute that

56:58

would put you at the top two and a half

56:59

percent for your age and sex so I'm

57:01

going to figure out is taking more

57:03

oxygen from the air that I breathe a

57:04

sign of good health yes it means it's it

57:07

speaks to how hard how fast and hard

57:11

your heart can pump yeah and how good

57:13

your muscles are at utilizing oxygen ah

57:17

okay it is the most important metric we

57:20

have for Peak cardiorespiratory Fitness

57:22

and sorry for getting a bit too big

57:25

because I really want to understand this

57:26

and I'm sure there's a lot of people

57:28

trying to understand this as well so

57:30

what are the things that stand in the

57:32

way of good VO2 max

57:33

in terms of my and also the the lungs

57:36

yeah it turns out that not much of it is

57:38

limited by the lungs so the question is

57:40

where are you limited okay okay so how

57:42

does this test work

57:44

do you prefer to run or bike I prefer to

57:46

bike okay so we're going to put you on a

57:48

bike we're gonna put this mask on your

57:50

face that allows no other air in or out

57:52

it's only going to be metered by what's

57:54

coming from the machine the bike is

57:57

going to be

57:59

um one that has forced resistance to it

58:01

it's called an ergometer so we're going

58:03

to set it to 100 Watts nice and easy I'm

58:05

going to tell you to warm up for a while

58:07

and then after a 10 minute warm-up it's

58:10

going to start increasing the power

58:12

that's that you are forced to Pedal

58:14

against okay and every two minutes we're

58:17

going to add some amount 25 or 50 Watts

58:21

and and you're going to say you have to

58:23

stay above about 70 rpm

58:26

and this test is going to go until you

58:28

can't do it anymore

58:30

it's going to go till you basically drop

58:32

so what's limiting you is clearly not

58:36

the amount of oxygen in the air

58:38

and it's actually not the ability of

58:40

your lungs to get oxygen into your blood

58:42

you're limited by the how hard and fast

58:47

your heart can pump that blood through

58:50

your body and how efficient your muscles

58:52

are at taking the oxygen out and using

58:55

it

58:56

and the difference between

58:59

so again a 30 year old who's in the top

59:03

two and a half percent of their age

59:04

group might be at 56 57 but to put that

59:08

in context the guy who wins the Tour de

59:11

France this year is 85. wow

59:16

and by the way when that number reaches

59:20

20

59:22

or certainly 18 19 you have a hard time

59:25

just getting around like you wouldn't be

59:27

able to walk up a flight of stairs

59:29

that gives you a sense of the of the

59:32

gradient now let's get to my point that

59:34

answers your question

59:37

you asked how can I say exercise is so

59:39

powerful well

59:41

what do you think is the hazard ratio

59:45

when I compare someone at the top two

59:47

and a half percent to someone at the

59:49

bottom 25 in terms of VO2 max yes

59:53

two percent versus the top bottom 25

59:55

bottom 25 that's quite big two percent

59:59

is quite narrow um I'd say

60:04

1.1.5 which is what so you think it's

60:07

less important than strength because

60:09

we've just established for strength it's

60:10

about three so I'm just I'm increasing

60:13

it now because I was so wrong on

60:14

strength yeah you see what I mean uh

60:17

well

60:18

what would I have said had you not told

60:20

me the strength one so

60:22

um by the way I think your guess is a

60:24

completely reasonable guess because the

60:25

answer is so absurd I'm gonna say 1.5

60:28

Hazard Hazard ratio it's five five which

60:32

means 400 percent difference in all

60:36

cause mortality

60:38

if you compare the fittest two and a

60:41

half percent to the least fit 25 percent

60:44

wow so it makes a huge difference

60:47

so this is why I can say with absolute

60:52

certainty nothing compares to exercise

60:57

nothing compares to having a high VO2

61:00

max High muscle mass and high muscle

61:02

strength

61:03

they are more beneficial for you than

61:07

any bad thing you can think of is bad

61:09

for you

61:16

why why the is the muscle mass piece so

61:19

important and the strength piece why is

61:21

that causing me to stay alive I think

61:24

there are several reasons as you get so

61:26

there's there's I put them in two

61:28

buckets structural and metabolic

61:31

let's start with the latter

61:33

muscles are where you dispose of glucose

61:37

so glucose regulation is one of the most

61:40

important metabolic functions of the

61:42

body

61:43

our ability to metabolize glucose and

61:46

regulate glucose levels is Central to

61:48

our existence on this planet and when we

61:50

get it just a little bit wrong we go to

61:53

hell in a hand basket that's what type 2

61:55

diabetes is type 2 diabetes raging type

61:58

2 diabetes

62:00

only means you have an extra

62:03

five grams of blood sugar one teaspoon

62:06

in your circulation that's it

62:08

the difference between you and someone

62:10

with type 2 diabetes so bad that they're

62:13

going to get their digits amputated

62:16

is an extra one teaspoon of glucose in

62:18

the bloodstream

62:20

that's how critical it is that we

62:23

regulate our blood sugar

62:25

and the most important part of blood

62:29

sugar regulation is having muscles that

62:32

are big enough to put the glucose into

62:34

and that are insulin sensitive enough to

62:36

respond to the signal of insulin

62:38

and glucose is stored in just a couple

62:40

of places in our body it's only stored

62:42

in the liver and in the muscles but the

62:43

muscles store 80 of it okay so okay so

62:47

muscles are really really good for

62:49

glucose regulation because it gives

62:51

the sugar more place to hide that's

62:53

right so the other reason muscle mass

62:56

and strength is so important is as we

62:59

age

63:00

fragility and Frailty become an enormous

63:04

liability in death

63:06

there's a figure in that book that shows

63:09

the mortality associated with falling

63:12

and it becomes

63:15

catastrophic once you hit the age of 65.

63:19

once you hit the age of 65 if you fall

63:23

which is pretty likely

63:25

and you break your hip or your femur the

63:28

long bone in your leg

63:30

there's a 15 to 30 percent chance you

63:32

will be dead within the next 12 months

63:35

really yes it's insane

63:38

because you become set a dream yeah

63:40

there's a lot of reasons for it but

63:43

certainly a loss of function is a big

63:45

one you can also just die as a result of

63:48

hitting your head you can die from a fat

63:50

embolism or a blood clot you can die

63:52

from sepsis you can die from you know

63:54

heart attack because you you know

63:56

there's there's so many things that can

63:58

kind of kill you in response to it but

64:00

even the people you know the 70 to 85

64:02

percent of people who don't die 50 of

64:04

them will experience a significant loss

64:06

of function that never recovers after

64:10

so this this issue of sarcopenia which

64:15

is loss of muscle mass and Frailty and

64:18

fragility become the you know the

64:22

absolute keeper of death for people once

64:25

they reach the seventh decade of life

64:27

again

64:28

if you're 30 years old it's impossible

64:31

to Fathom this stuff because you're

64:33

indestructible yeah yeah even at my age

64:35

I mean I feel indestructible and I'm 50

64:38

but this changes and we have to do all

64:42

we can to Ward it off so that's why

64:44

muscle mass matters so much

64:48

there's this kind of long-standing

64:50

belief that you as you age there's so

64:52

many just it's just kind of inevitable

64:54

you put on fat you know you slow down

64:57

and you're saying and I think you

64:59

communicated very clearly in the book

65:00

that it doesn't have to be inevitable

65:02

all of this stuff to some degree well I

65:04

mean look I I'm I'm very I'm very

65:07

careful to to try to be as realistic as

65:10

possible I I get a little put off when I

65:13

see people in this sort of quote-unquote

65:15

longevity space saying things that I

65:17

think are just science fiction right

65:19

like oh you're at 90 you can be just as

65:21

fit as you are at 40 and stuff and I I

65:24

see Zero evidence that that's happening

65:26

I don't see any biotechnology on the

65:29

horizon that is going to completely and

65:32

reversibly change aging

65:34

um yet

65:36

I don't think In Our Lifetime no and

65:39

this is something I spend

65:41

you know

65:43

an absurd amount of time on both as an

65:46

investor uh and and just as a you know a

65:49

person who thinks about this from my own

65:51

podcast and the types of guests that I

65:52

bring on and the type of science that

65:54

I'm paying attention to but but no I

65:56

really do not see anything in our

65:58

lifetime that is going to undo aging I

66:01

think we have some ideas of

66:04

places we can look right I think that

66:07

for example

66:09

if you could

66:11

completely restore the epigenome to what

66:15

it looks like in a young State across

66:18

the entire genome I think that could

66:21

have a profound effect

66:22

on function

66:24

but do we have do I see ways that we

66:27

could do that I

66:29

it you know it's a longer discussion but

66:31

I think the complexity there is many

66:34

many decades away that said

66:38

um what I think we do not need to do is

66:41

accept the complete and total

66:42

inevitability of Rapid decline so the

66:46

decline is non-linear

66:48

this is the important thing to

66:49

understand so what was your decline from

66:52

20 to 30.

66:54

wasn't that bad no no and from 30 to 40

66:57

it's not going to be that bad from 40 to

67:00

50 it's going to be more from 50 to 60

67:02

it's going to be even more from 60 to 70

67:05

it's going to be way more and 70 to 80

67:08

is falling off a cliff

67:10

so if you if you look at this is

67:12

actually one of the figures I wanted to

67:13

include in the book but you know you're

67:14

always sort of scrapped for space so we

67:16

took it out but I have a figure that

67:18

shows both muscle mass and spontaneous

67:21

physical activity in people by decade

67:23

and it's just based on like a huge data

67:26

sample of people and it's really

67:28

interesting to watch the correlation how

67:30

strong it is right so physical activity

67:33

and muscle mass go like this and they

67:36

just fall off a cliff and the cliff for

67:38

both is 75 for both men and women like

67:41

that's where you see an enormous

67:43

reduction in muscle mass and activity

67:45

level

67:45

because of Behavioral well I think it's

67:48

a you know it's the age-old question is

67:51

are they losing muscle mass because

67:52

they're becoming less active or are they

67:54

becoming less active because they're

67:55

losing muscle muscle mass and I think

67:57

it's both okay I think these two feed

67:59

off each other

68:00

and um and they get haunted right

68:02

presumably because what you said about

68:03

the quality of the muscle as well that's

68:05

right so you have to Ward this stuff off

68:07

right I mean as your type 2 muscle

68:09

fibers are deteriorating and you're

68:12

putting more fat into muscle the quality

68:14

of that muscle you go from being you

68:17

know primed to wagyu so you have to Ward

68:20

that stuff off

68:21

right and the way to Ward that off is to

68:23

lift very heavy things that's the only

68:25

way to stimulate the type 2 muscle fiber

68:28

this type 2 muscle fiber won't get

68:29

stimulated by light movements so it's

68:33

not just that resistance training is

68:34

necessary but it's it's resistance

68:35

training that's actually quite heavy

68:38

people who hear that they go okay they

68:40

get it they're on board they're going to

68:41

exercise how much do I need to do

68:43

because listen

68:45

can it be is it I've got to change my

68:48

whole life in exercise seven days a week

68:49

and run marathons now Dr Peter or is

68:52

this what would you recommend I always

68:54

start this question by saying

68:57

how much can you do

68:59

but okay I'm gonna I'm gonna play

69:01

devil's advocate here I'm gonna respond

69:03

as one of my viewers right I'm gonna say

69:04

listen I'm so busy you don't understand

69:06

Dr Peter I'm I've got kids I've got this

69:09

I've got a job I'm already I already

69:10

have no time I'm not sleeping out here

69:13

so I don't have any time

69:16

I mean I I it requires a thorough

69:18

discussion around that I mean is that

69:20

really true no of course it's not yeah

69:22

so then you have to get into the weeds

69:23

like how much time are you watching TV

69:25

how much time are you on social media

69:26

how much time are you doing things that

69:28

might not be

69:30

um as high a priority as doing this

69:31

other thing

69:34

um so so once you kind of get through

69:37

that I do I do sort of put put it on

69:39

them and say I would much rather you

69:41

tell me the number than I tell you the

69:43

number

69:44

I can tell you what I think the number

69:45

is right like if you're playing the

69:46

optimizing game and if you're saying

69:51

I want to be the absolute best fittest

69:54

version

69:56

of me that is humanly possible when I'm

69:59

in my 80s how much do I need to be

70:02

training for that the answer is probably

70:05

one and a half to two hours a day

70:08

one and a half to two hours a day seven

70:10

days a week yeah

70:12

I mean of course it's not going to be

70:13

the same every day and and it looks

70:15

different but but it's going to average

70:16

out to 10 to 14 hours a week

70:19

but but rather than tell somebody that

70:21

because I think that's very off-putting

70:22

yeah I would just say just tell me what

70:25

you got

70:27

if you tell me you've got five hours a

70:29

week that you can do this I'll give you

70:31

a great set of things you can do in five

70:32

hours and My Hope by the way is

70:35

six months from now you're gonna feel so

70:37

much better that you're gonna say you

70:39

know what I would like to up this to

70:41

seven hours a week

70:43

what's the difference in all cause

70:44

mortality if I go from doing zero

70:46

exercise to doing just a bit yeah that

70:48

that's a great question

70:50

and for some people that question is all

70:52

they need to get started

70:54

going from zero activity to just 90

70:59

minutes a week is about a 15 reduction

71:01

in all cause mortality so I'm 50 less

71:04

likely to to die in any given Year from

71:07

all causes if you go from being

71:09

completely sedentary to just doing 90

71:11

minutes a week

71:13

which is only like what I know 15

71:16

minutes a day 12 minutes a day yeah or

71:17

just you know three times 30 minutes a

71:19

week

71:20

that's a huge that's a huge shifting of

71:23

very important odds yeah

71:26

and and truthfully like I

71:29

probably spend more time convincing

71:32

people not on the all-cause mortality

71:34

data

71:35

but on the health spandex because people

71:38

don't we didn't think about it yeah

71:39

death is so abstract it really I don't

71:42

think it I don't think it even sets in

71:45

until you're in your 50s like I think

71:47

it's very

71:49

it's very hard to capture the finitude

71:53

of what it means to be a human when

71:55

you're young I think it's true at all

71:56

ages but but I really think

72:00

it's so much better to just focus on the

72:03

quality of life you want to live

72:05

what do you want to physically be able

72:06

to do throughout your life

72:09

and it's easier in people who have been

72:12

around aging people

72:14

yeah you know which again

72:16

a lot of people in their 30s their

72:18

parents aren't even necessarily old

72:21

enough that they can fully appreciate it

72:23

they might have to think well do I still

72:25

remember what my grandparents were like

72:27

at the end of their life and

72:29

was I inspired by them and if so that's

72:31

what I want to do great and if I don't

72:35

want what they had which is the answer I

72:37

think most people will have then what do

72:40

I need to do to be different what was it

72:41

for you I remember what it was for me

72:43

yeah for me it's again it's I didn't

72:47

know my grandparents uh

72:51

I suspect just my training in medicine

72:53

like I was around

72:55

so many people at the end of life that

72:57

like to see yeah it was it was just

73:00

imprinted early my arm I told this story

73:03

once or twice in this podcast before but

73:04

I was in Bali walking down some a long

73:07

set of stairs when I say alongside of

73:09

stairs I mean down the side of a cliff

73:11

going down to canoe with my partner and

73:14

I was walking down those stairs in the

73:15

sunshine it dawned on me that my father

73:17

probably couldn't walk down these steps

73:19

and my dad is maybe a 60 65 and I

73:23

thought he wouldn't be able to come down

73:24

these stairs which means he wouldn't be

73:25

able to go canoeing with his family and

73:27

we share a lot of genetic uh information

73:30

me and my father of course so that was

73:32

one of those real big moments and

73:34

actually Jack who films the podcast he

73:36

he after I shared that with him he and

73:38

we had some guests on the podcast

73:39

um he shared with me his own moment

73:41

where he was climbing a mountain I think

73:42

last month weren't you Jack

73:44

and he he got to the top of the mountain

73:46

and thought to himself God like it was

73:48

such an unbelievable experience for him

73:49

uh he correct me if I'm wrong it was an

73:52

epiphany moment you go I wouldn't be

73:54

able to climb this bloody mountain with

73:55

all these people and feel this sense of

73:56

accomplishment if I and it's those

73:58

moments for me where I thought this

74:00

is that's my health span I want to be

74:02

able to do this yes

74:03

you wrote one of the chapters in your

74:05

book is about stability um

74:07

found that really

74:08

um surprising again I'd never even come

74:11

across the concept of stability or why

74:12

it's important that's why it needed an

74:14

entire chapter because it is a very

74:16

foreign concept chapter 13 stability why

74:19

why is it important and what does it

74:22

mean yeah I think this is this is the

74:24

stability is a difficult thing to

74:25

explain I mean you can sort of talk

74:27

about it technically right stability is

74:29

the capacity to transmit force from the

74:32

body to the outside world and from the

74:34

outside world back to the body without

74:35

injury so anytime you're taking a step

74:38

you're applying Force to the ground

74:40

that's

74:42

what's allowing you to walk forward so

74:44

you apply Force to the ground the ground

74:45

applies an equal opposite Force to you

74:47

that's Newton's law and you move forward

74:50

um when you're running why are you going

74:52

faster

74:54

you're going faster primarily because

74:55

you're applying more Force to the ground

74:57

and therefore the ground is applying

74:59

more Force to you and that's propelling

75:01

you forward

75:02

the difference between me and Usain Bolt

75:06

among other things is his capacity to

75:09

apply Force to the ground is

75:12

two and a half times my ability to apply

75:15

Force to the ground

75:17

so in all that Force

75:20

how do you make sure that the action of

75:24

the force mechanism is all for the

75:27

desired purpose in this case propulsion

75:29

and not for undesirable purposes like

75:33

leaking of energy which is what it feels

75:36

like when your knee hurts when you're

75:37

walking down the stairs or your hip or

75:39

something like that

75:41

so the analogy I use in the book to

75:43

describe this is that of a car because I

75:45

love cars and I talk about the

75:47

difference between a race car and a

75:49

street car

75:50

a race car can be even half the power of

75:53

A Streetcar in terms of horsepower

75:55

but because it's smaller lighter and has

75:57

a stiffer chassis and slick tires

76:00

much more of its power is being

76:03

delivered directly to the road without

76:05

slippage or energy loss and therefore

76:07

it's going faster

76:09

and so this idea is a very important

76:13

part of aging so most people who have

76:16

some sort of chronic injury it can

76:18

really be traced back to an instability

76:20

whether it be an instability of their

76:23

scapula and that's why they really have

76:24

tennis elbow or an instability in the

76:28

you know in in their abdomen in their

76:31

lower back and that's why they have back

76:32

pain instability in the feet that

76:35

translates its way up into knee pain all

76:38

of these things matter greatly and a big

76:42

part of how we train is making sure that

76:46

we do exercises that bolster our

76:48

stability

76:50

again this feels very um relevant to me

76:52

because I'm

76:53

currently got a Grade Three tear in my

76:55

hamstring got a growing problem so I'm

76:57

on physio for the grade three tear how

76:59

did you tear it

77:00

um playing football but I have a couple

77:02

of suspicions surrounding it because

77:03

about a month before I got the

77:07

foot pain that they call plantar

77:09

fasciitis plantar fasciitis so I went to

77:12

the I think it's called a podiatrist and

77:13

I got my foot x-ray things done where

77:16

they give you the insoles and then

77:17

following that I got loads of injuries

77:20

um I think my hypothesis is that I took

77:22

these insoles put them straight in and

77:24

then proceeded to do two hours of

77:25

football basically running a day and I

77:28

think something in me just broke because

77:29

I suddenly got all these injuries and

77:31

then I was meant to be playing Old

77:32

Trafford Manchester United's football

77:34

ground in front of 70 000 people and the

77:36

day before in training I got I pulled my

77:38

hamstring

77:39

um and I and I and I think that

77:41

everyone's been speaking to me about my

77:43

injury and saying well you know maybe it

77:44

was something in your lower back and

77:46

maybe this and maybe your feet weren't

77:48

whatever

77:49

um kind of rings true to what you're

77:51

saying about stability I clearly have

77:52

something which is not wasn't wasn't

77:54

prepared for me to suddenly start

77:55

training for two hours a day

77:58

um

77:59

and everything started breaking

78:01

well and look I mean it's it's

78:04

hamstring injuries are very stubborn

78:06

injuries

78:08

um and a lot of people are really

78:11

imbalanced right much stronger quads

78:13

than hamstrings

78:15

um my personal take is and I'm sure I'm

78:18

going to really upset some podiatrists

78:20

here I think that

78:22

um that insoles foot inserts uh arches

78:26

arch support

78:27

probably should be reserved only for

78:30

some people and most people actually

78:32

need to learn to strengthen the

78:33

intrinsic muscles of the foot and that

78:36

that's the issue that's underpinning the

78:38

plantar fasciitis and once you have a

78:41

Str Because by the way your foot is not

78:43

that much different from your hand in

78:45

terms of the amount of musculature in it

78:47

and yet if you think about the dexterity

78:49

that you have with your hands and the

78:51

strength that you have in your hands I

78:53

think you'd be surprised at how weak

78:55

your feet are and I don't just mean you

78:56

I'm not singling you out I think this is

78:58

true for most of us because shoes really

79:01

Shield us so much from what our feet

79:04

should be doing

79:05

so

79:07

um yeah I think I think your hypothesis

79:09

is actually probably spot on and I think

79:12

what you really need to do is strengthen

79:13

your feet so that your arches

79:16

can can self-support

79:19

um and that you can sort of regain the

79:21

springiness that is that is within your

79:23

feet I spoke to Dr Daniel Lieberman

79:25

about this yeah yeah he said the same

79:26

thing yeah he said your feet were too

79:28

weak and it makes perfect sense to me

79:30

because I do not think about I always

79:31

think in terms of my ancestors and I

79:33

think my ancestors didn't walk in these

79:35

cushioned blunts Yaga shoes they were

79:38

out Barefoot yeah building up the

79:40

strength and so when I went from my

79:41

cushioned balenciagas to suddenly

79:43

training two hours a day on feet that

79:45

just didn't have the muscles of course I

79:47

I pulled loads of I had all these issues

79:49

and so I actually changed my Footwear

79:51

and I don't have the insoles anymore and

79:53

I'm now using those Vivo Barefoot yep do

79:56

you recommend those do you think I do I

79:58

really I mean again I think there's lots

79:59

of companies that make them I wear a

80:01

brand called zero like x-e-r-o

80:04

um and and but the Vivo barefoot's a

80:07

great brand and I yeah I think that a

80:09

minimalist shoe is a great way to go I I

80:12

have the luxury of basically working

80:14

from home so I'm pretty much Barefoot 24

80:16

7. I I work out Barefoot and my own gym

80:19

like I I'm I'm in my and then when I do

80:22

my activities like my rucking and stuff

80:24

like that when I'm Outdoors like I'm you

80:26

know I'm in a wide toed shoe that is uh

80:30

you know at most would have maybe an

80:32

eight millimeter uh

80:34

um increase in heel but yes minimalist

80:36

shoe now one thing to keep in mind is if

80:38

you're transitioning from Big shoe to

80:41

minimalist shoe don't do it all at once

80:43

so

80:44

um you can also injure yourself in the

80:46

right shoes if it's too much too soon

80:49

they did say that to me when I bought

80:51

them yeah they said just like sort of

80:53

ease yourself in because you need to

80:54

build up the muscles in your feet super

80:56

interesting no one's ever spoken to me

80:58

about this before but

80:59

um I just find it saying I'm like why

81:01

did anybody tell me this I mean we do a

81:02

lot of things if you think about it like

81:03

think of all the things we do to kids at

81:05

such a young age that set them down the

81:07

wrong path right like we put them in big

81:09

shoes when they're little we put them in

81:11

desks to sit down in class and we take

81:14

away a lot of physical activity Comfort

81:16

we prescribe Comfort to everything yeah

81:19

convenience have you read the Comfort

81:21

crisis by Michael Easter no oh man such

81:25

a such a fantastic book

81:28

and it talks about this oh yeah I mean

81:30

it's really the whole thesis of the book

81:31

right is that we have engineered

81:33

discomfort completely out of our lives

81:35

and uh it's a you know it's an enormous

81:39

problem

81:39

both for our physical and mental health

81:41

the answers are actually quite simple

81:43

when you reflect upon it you go you know

81:45

how are we born to live we're so far

81:47

away from how we were born to live and

81:48

if I just followed more of

81:50

um the instruction manual of my

81:52

ancestors maybe I wouldn't have all of

81:53

these kind of

81:55

you know modern issues with that comfort

81:58

in many many respects has caused me

82:00

but it's tough because you have to sort

82:02

of think about what is the

82:06

there are a lot of gifts that come from

82:08

the modern world right and like I don't

82:11

think you would want to go back in time

82:12

100 years and be alive I probably

82:14

wouldn't live very long would I either

82:16

yeah I mean and let's let's even make it

82:19

less than that like let's say even 70

82:22

years like you know once we're through

82:25

the sort of infectious pandemic stuff

82:26

right like what you know would we really

82:28

want to go back and be alive 70 years

82:30

ago just before World War II I mean I I

82:33

wouldn't like I yeah they had

82:36

electricity and stuff but I I like the

82:38

modern world but there's a huge set of

82:42

responsibilities that comes with the

82:43

modernity of our world today

82:46

food is so abundant today I mean these

82:48

people did not struggle with obesity

82:50

because they weren't surrounded by

82:52

really tasty hyper hyper palatable

82:55

calorie dense food in total excess we

82:59

are

82:59

that means we have to exercise some

83:01

moderation

83:02

most of them had far more physical jobs

83:04

than you and I do

83:06

I mean

83:07

you and I don't have to lift a finger to

83:09

make a living

83:11

whereas 75 years ago we probably did

83:15

and it's great that we don't have to I

83:16

think you could argue look you're having

83:18

a far bigger impact on the world than

83:20

you would have ever had 75 years ago but

83:22

that comes with a responsibility to

83:24

yourself is this one I was seeing this

83:25

sort of resurgence of discomfort as a

83:28

hobby and a sport in an industry I think

83:30

so yeah I I think so and and again

83:32

Michael writes about this so

83:35

um so well you know they write about he

83:37

writes about things called musogi's

83:38

which are these very very difficult

83:40

challenging things that you might have

83:42

yourself do once a year

83:45

um he also writes a lot about something

83:47

that is just an enormous hobby of mine

83:50

called rucking have you are you familiar

83:52

with rucking so rucking is something

83:54

that I I think it was probably started

83:55

by the military and it's really how the

83:57

military does the great majority of its

84:00

conditioning and it's walking with a

84:03

weighted backpack

84:05

um and I mean the military will do this

84:08

they might go on a 24-hour Ruck where

84:11

you're carrying half your body weight

84:13

so picture you carrying in your case

84:16

right like close to a hundred pounds on

84:19

your back for a day

84:21

and

84:23

um so there's actually an awesome

84:25

company in the U.S called go rock that

84:28

makes really good rucksacks that are

84:31

just ergonomically designed to put

84:33

weight plates into and then they sell

84:35

these plates and stuff so I mean this

84:38

has become a total Obsession of mine so

84:40

I rock three or four times every week

84:42

and luckily where I live in Austin Texas

84:45

it's incredibly hilly so it's just up

84:48

and down up and down very steep hills

84:50

and I'll go anywhere from you know 50 60

84:54

pounds on some days I'll really push it

84:56

and go up to a hundred uh for shorter

84:58

rucks and you know I'm only doing it for

85:01

like an hour at a time but we it's very

85:03

hot where I live in the summer so it's

85:06

just it adds an extra layer of

85:07

discomfort but it's great

85:10

yeah because I don't know whether it was

85:12

just what the circle I'm exposed to in

85:14

the information I'm exposed to but it

85:15

just seems like all of these Ultra

85:16

athletic you know painful long distance

85:21

um Sports have become super popular the

85:23

Spartans of the you know I actually just

85:25

recently invested in one

85:27

um because of this very reason because

85:28

I'm seeing this Comfort crisis and I

85:29

always think that when there's one one

85:31

pole Rises the other one Also Rises so

85:34

when digital music record you know old

85:36

school vinyl records became big and I

85:37

think in a world of comfort people are

85:39

going to seek out extreme discomfort and

85:41

it sounds like you're doing that with

85:42

your rucking yeah if you've been

85:44

listening to this podcast over the last

85:45

few months you'll know that we're

85:47

sponsored and supported by Airbnb but it

85:50

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85:52

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85:53

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85:55

works away a lot it just makes sense to

85:57

Airbnb my place at home whilst I'm away

86:00

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86:02

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86:04

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86:07

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86:09

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86:22

that's airbnb.co.uk slash host sugar is

86:27

it an interesting topic because it's

86:29

really been demonized I think and may

86:31

maybe rightfully so but

86:34

um I wanted to talk to you about sugar

86:35

because it's actually been really front

86:36

of mind for me lately and when I say A

86:38

little I mean literally in the last 48

86:39

hours I'm I went away to a a wedding

86:44

um and I remember they didn't have a lot

86:46

of drinks so I was opting for the

86:48

sugar-free drinks the things that say no

86:50

added sugar in them like you know I

86:52

won't name the brands but the ones that

86:54

have zero and diet on them

86:57

first question is

86:59

is sugar the devil as people have become

87:02

to tell me and also if I'm drinking

87:04

these zero drinks with the diet and the

87:06

zero on it am I in the clear

87:10

this is a very complicated topic and I

87:12

think it's one that's also very

87:13

contentious

87:15

and it's also one in which I've probably

87:20

my thinking has probably also evolved as

87:23

as as the science I think has kind of

87:25

evolved so

87:27

let's start with what I don't think

87:29

anybody disputes I don't think there's

87:31

any anybody out there thinking that high

87:33

sugar foods are somehow nutritious right

87:36

that's not the question at hand

87:38

the question is

87:40

calorie for calorie

87:43

is sugar somehow different from let's

87:47

just limit it to other sources of

87:48

carbohydrates

87:50

so

87:51

what is sugar so I'm assuming when

87:53

you're talking about sugar you're

87:54

talking about sucrose or high fructose

87:56

corn syrup those would be the two

87:57

dominant forms of sugar but just to

88:00

demystify it sucrose which is the white

88:02

powder you would put in your coffee or

88:04

tea that's just one molecule of glucose

88:07

and one molecule of fructose stuck

88:09

together that's table sugar

88:12

and if you contrast that with pure

88:14

glucose so like eating rice is basically

88:18

pure glucose it's going to be broken

88:19

down into pure glucose how different are

88:22

they well obviously the thing that

88:23

differentiates them is the fructose

88:25

that's the thing that's different now

88:27

it's true that fructose has a very

88:29

different Pathway to be metabolized

88:32

the body breaks down fructose in a very

88:36

different way from the way it breaks

88:37

down glucose and by breaks down I mean

88:39

it gets energy from it the whole purpose

88:42

of eating is to make this thing called

88:44

ATP ATP is the currency of life it's the

88:48

currency by which energy is transmitted

88:50

throughout the body

88:51

and the way we make ATP out of glucose

88:53

is

88:56

I think I can probably say this smarter

88:59

than the way we make it out of fructose

89:02

the way we make it out of fructose has a

89:05

problem a slight problem now it doesn't

89:07

really matter if you're not consuming a

89:09

lot of fructose

89:11

but if you're consuming fructose in a

89:13

liquid form it has a real problem I.E if

89:17

you are drinking sugar

89:19

there's a real problem

89:21

and the problem is this when you make

89:24

ATP out of fructose you temporarily

89:28

deplete the cell of energy to the point

89:31

where more energy is needed

89:36

this is just a consequence of the speed

89:39

at which we metabolize fructose

89:42

we do it quickly all the time in this

89:44

way but if you're eating an apple for

89:48

example it's not really an issue because

89:51

yes the Apple has fructose in it

89:53

but you know it's not that it's not that

89:56

much and you're eating it so it's it's a

89:59

piece of solid food with fiber and water

90:01

that's taking a long time to exit your

90:03

stomach but if you drink a big glass of

90:05

apple juice

90:08

well I mean first of all that's much

90:10

more fructose and it's liquid and it's

90:12

just going straight out of your stomach

90:13

and your liver is going to encounter it

90:15

much sooner as is your gut

90:17

and therefore you're much more likely to

90:20

want to eat more

90:22

after in other words it creates more of

90:25

a hunger response

90:27

so the real issue with sugar is calorie

90:30

for calorie is it more damaging than

90:33

just glucose

90:35

I actually think the answer to that

90:36

question is probably not

90:38

really yeah but

90:41

in the real world

90:44

is that possible

90:46

in other words if I put you in a

90:49

metabolic ward in a hospital where you

90:51

had no control over what you ate other

90:53

than me putting it in front of you and I

90:55

gave you two different diets and one was

90:58

higher in fructose than the other I'm

91:01

not convinced it would make that much of

91:04

a difference

91:05

it's possible it would if we went to

91:07

extremes you know maybe at a high enough

91:09

fructose level we might actually induce

91:12

more fat production in the liver we

91:14

might actually create some fatty liver

91:15

disease maybe even drive insulin

91:18

resistance

91:19

um but I might have to go pretty high on

91:21

that but

91:23

the real problem is if I just let you

91:25

have as much fructose and sugar as you

91:27

wanted you'd probably end up overeating

91:30

in response to this energy depletion

91:34

thing

91:35

so

91:36

I don't sort of describe myself as like

91:39

a hardcore sugar avoider I mean

91:42

like we're here in London and I mean I'm

91:46

gonna have dessert probably most nights

91:48

right I'm on vacation

91:51

um

91:52

but I also acknowledge it that it's you

91:57

know like not something that I want to

91:59

be eating on a regular basis you know

92:01

just added sugar all the time

92:04

um

92:06

I don't drink sugar sweetened beverages

92:08

that's definitely a place where I draw a

92:09

line so I think there's something about

92:11

liquid sugar that is more problematic

92:13

than solid sugar

92:15

um so I'd rather eat my sugar

92:18

and at least have the benefit of it

92:21

being more slowly absorbed than drink it

92:25

um what's always diet drinks though yeah

92:27

so I look I don't drink them personally

92:30

very often

92:32

um and in part that's I think due to

92:38

a little bit of uncertainty I think we

92:40

still have about their impact on our

92:42

metabolism through our gut

92:45

I think there's

92:47

I think there were emerging

92:50

data that suggests that

92:53

at least certain non-nutritive

92:55

sweeteners like things like

92:58

um well in the U.S it's like NutraSweet

93:01

I think

93:03

it's Aspartame is the underlying agent

93:06

or saccharine or sucralose I think

93:10

there's some

93:12

some suggestion that the effect that

93:15

they have on the bacteria on your gut

93:17

might be detrimental to your health I

93:19

think it's too soon to really say that

93:21

but my view is

93:24

don't take the risk well I don't need to

93:26

I suppose like I'm I'm I love soda water

93:30

like I love carbonated water so I'm just

93:32

happy to drink that but I'm sure once a

93:34

month I'm gonna have a Diet Coke or

93:36

something but it's not a regular thing

93:38

but I but I will say this when I see

93:39

people who are struggling for example

93:41

with weight loss

93:43

and they're drinking four Diet Cokes a

93:45

day

93:46

one of the first things I'll do is have

93:48

them stop completely and replace that

93:50

with just water or sparkling water why

93:52

uh I'm not sure I I just empirically

93:56

have seen even though they're not

93:57

getting any calories that a either it's

94:00

impacting their eating behavior when

94:02

they're not drinking the coke uh or

94:05

maybe it's having some negative impact

94:06

on their gut that is that is impacting

94:09

the way they're metabolizing their food

94:11

this is this is rather unscientific at

94:13

this point but it's just empirically is

94:14

something I've observed everyone cares

94:16

about weight loss

94:17

it's such a big topic everyone wants to

94:19

lose weight I mean as you clearly

94:22

um

94:23

specify people want to lose fat they

94:26

don't want to lose weight people want

94:26

lose fat which is something I heard you

94:28

say

94:29

um what are the the biggest

94:30

misconceptions in your mind about weight

94:32

loss because but I guess the narrative

94:35

is to lose weight you kind of you just

94:36

need to eat less that's kind of the

94:39

is that true and what are the big

94:41

misconceptions that you hear that we

94:42

need to overcome yeah I think that is

94:44

largely true I think that

94:46

um eating less

94:48

uh is the the more important step

94:51

towards weight loss

94:53

um and that the role of exercise is

94:56

important but less because of just the

95:00

straight number of calories you burn in

95:01

other words the increase in energy that

95:04

you expend through exercise is usually

95:07

offset by increased appetite you use the

95:10

word calories there yeah contentious

95:12

words sometimes

95:13

it shouldn't be people people come and

95:16

come on this podcast and told me that

95:17

calories are like the concept of it's

95:19

kind of like a lie in the sense that

95:21

they're not all even some cat you know a

95:24

stick of celery has this many calories

95:25

and then when you boil it has this many

95:27

calories and it's

95:29

well yeah I think people tend to

95:32

get a little off in the Weeds on stuff

95:34

that that might not matter that much

95:36

um

95:37

yeah it's certainly true that not all

95:39

calories

95:41

um are absorbable the same way and an

95:43

example of celery is a pretty extreme

95:45

example because so much of celery is

95:49

um an insoluble fiber right so most of

95:52

the mass of celery is water and

95:53

insoluble fiber there are virtually no

95:55

calories in celery

95:58

um but at the end of the day it's not

96:00

rocket science to figure out how many

96:02

calories you're ingesting in a certain

96:04

amount of food and the truth of it is if

96:07

a person wants to lose weight as you

96:11

said what they really want to do is lose

96:13

fat Mass there's I've never met anybody

96:15

out there who says I want to have less

96:16

muscle so we want to have less fat and

96:20

therefore we have to create an energy

96:21

deficit

96:23

um

96:24

now there are other elements to this

96:26

that matter so we don't we just want to

96:28

leave on the side that if you're sleep

96:30

deprived you're going to be very insulin

96:33

resistant

96:34

it's that's a much easier path to being

96:36

overweight

96:38

not sleeping not sleeping right so you

96:40

you can't correct a weight problem

96:42

without correcting a sleep problem what

96:44

about a stress problem yep that's even

96:47

harder to correct because it's harder to

96:49

measure

96:50

but yes hypercortisolemia high stress

96:52

makes it very difficult to lose weight

96:54

my partner said this to me this weekend

96:56

she was trying to figure out how in one

96:58

stage of her life when she was in her

97:00

words eating very very healthy food she

97:02

says I still wasn't losing weight and

97:04

she she hypothesized in the car as we

97:06

were driving that she thought it might

97:07

be to do with her stress levels at that

97:08

time in her life and I remember thinking

97:11

oh that's an interesting hypothesis

97:13

yeah so high stress poor sleep

97:16

inactivity all of those things will make

97:19

it very difficult to lose weight even in

97:22

the presence of whatever perfect diet

97:24

you're on so those things have to be

97:27

addressed right you have to be sleeping

97:29

well you have to be active because

97:31

activity increases insulin sensitivity

97:34

and we want those muscles to be

97:35

sensitive to insulin so that they

97:38

quickly get glucose out of circulation

97:40

and also exercise increases the

97:44

sensitivity of your brain to what are

97:47

called satiety hormones the hormones

97:49

that tell you when to stop eating

97:51

so and and the difference between an

97:54

exercising person and a non-exercising

97:56

person uh is that that non-exercising

97:59

person has a blunted response to those

98:02

hormones so sometimes they're eating

98:05

when they don't need to be eating

98:06

they're not getting the message that

98:09

says we have enough nutrition on board

98:11

now anybody can blow through that signal

98:13

but I would like to know that that

98:15

signal is there

98:16

so when all of that is said the question

98:20

then becomes how do you create an energy

98:22

deficit

98:23

and basically

98:25

there are three ways to do it

98:27

there are three strategies to create an

98:29

energy deficit

98:31

I'd describe them as CR Dr TR so that

98:34

stands for calorie restriction

98:37

dietary restriction and time restriction

98:42

so let's explain them okay so calorie

98:45

restriction is what it sounds like just

98:47

eat less that's the most direct way to

98:50

go about doing this

98:51

so you know I gotta eat 500 fewer

98:55

calories a day and I'm gonna have to

98:57

track what I'm eating and count my

99:00

macros and make that happen Okay that

99:02

has the advantage of being the most

99:05

direct way to do this but it has a

99:08

disadvantage frankly of

99:10

being harder to do in some ways you have

99:12

to pay the most attention to it it also

99:15

has the advantage by the way of being

99:17

pretty flexible and agnostic to what you

99:20

eat so

99:22

you know there are certain foods you

99:23

like

99:25

there's no food that's off the table

99:26

when you're doing calorie restriction it

99:29

provided you're eating less overall got

99:31

a friend that said this to me he said it

99:33

doesn't matter what you eat just

99:34

restrict the calories remember thinking

99:36

that was strange advice because he was

99:37

like you can have Domino's Pizza every

99:39

day you just if you'll lose weight if

99:40

you have less calories that's right now

99:42

the problem is he's absolutely right but

99:44

the problem is

99:46

it can be very difficult

99:49

to not suffer through calorie

99:51

restriction if you're just eating crap

99:54

because the body still at the end of the

99:56

day keeps score with respect to

99:58

nutrition

100:00

and the body still wants protein the

100:02

body still wants nutrients the body

100:05

still wants vitamins minerals so if you

100:08

say look I'm going to eat 2 000 calories

100:09

a day a Cadbury's

100:12

you might lose weight but you'll

100:14

probably be in purgatory along the way

100:16

and you certainly won't be healthy so we

100:18

also want to make sure we're not

100:19

confusing health and weight here

100:21

now we come to dietary restriction

100:23

dietary restriction is what most people

100:24

think of when they think of a diet this

100:27

means

100:28

as I described in the book you know pick

100:30

your favorite Boogeyman

100:32

or two and just cut them out of the diet

100:34

so basically everybody that's arguing

100:36

about their perfect diet is arguing

100:38

about dietary restriction so you want to

100:41

take out carbs you want to take out

100:42

animal products you want to take out

100:45

everything but meat you know it's a

100:46

carnivore diet you want to go South

100:48

Beach paleo Mediterranean those are all

100:50

just forms of dietary restriction

100:52

and

100:54

generally speaking the more restrictive

100:56

you are in the diet the less you will

100:59

eat

101:00

so I mean it's I don't think it's an

101:02

accident that people who go on a

101:03

carnivore diet typically lose a ton of

101:05

weight same is true of a ketogenic diet

101:08

I did it yeah my scales it was like this

101:11

this was the it was a it was a

101:13

horizontal line my weight maybe a little

101:15

bit up and then I did keto for eight

101:17

weeks and it was a vertical line down

101:19

every time I hit those scales and the

101:20

Bluetooth thing sent to my weight to my

101:22

phone this vertical line down I lost a

101:24

stone in the space of those eight weeks

101:26

roughly my girlfriend was like stone is

101:28

16 pounds something like that yeah eight

101:30

kilos 14 step what do they go from 14

101:32

Stone 5 to 14 Stone 8 to 13 stone eight

101:36

yeah which I think yeah

101:38

and were you hungry

101:42

um I couldn't sustain it easily I'd say

101:46

that because if we went to restaurants

101:47

and stuff I was always trying to get

101:49

like taking corn out of it like taking

101:51

the wrap off a burrito and stuff and

101:53

um whatever else um was I hungry after I

101:56

got past the first week I wouldn't say I

101:58

was hungry no but I also didn't find it

102:01

sustainable because of honestly because

102:03

of the nature of the modern world where

102:04

it's so hard to find those things when

102:06

you're living a very fast-paced life

102:08

hungry for some kind of nutrient maybe I

102:11

think there was some kind of

102:12

psychological calling to go back to work

102:14

to my previous diet and then I went to

102:16

New York and that's when it fell down

102:18

and then did you regain the weight or

102:20

what happened oh yes

102:22

oh yes just as fast as I lost it I went

102:25

from this keto diet to the New York diet

102:26

and it was so extreme how quickly I put

102:28

that weight back on again

102:30

um just being honest yeah well it's

102:33

interesting right so I again it's a very

102:35

extreme diet and I think you know people

102:37

are gonna definitely lose lose weight on

102:39

it and and look for some people it's

102:40

easy to sustain for others it's not

102:44

um but nevertheless that's dietary

102:46

restriction and again I think the

102:47

advantage of dietary restriction is

102:50

you're not being restricted in the

102:52

amount you eat you're just being

102:54

restricted in what you eat and

102:58

um The Challenge then really comes down

103:00

to the craving of certain types of foods

103:02

so obviously on a ketogenic diet you're

103:03

going to really crave carbohydrates

103:06

um yeah so the final strategy is time

103:10

restriction and people call this

103:12

intermittent fasting as well but it's

103:13

basically saying all right how about I

103:16

create a smaller window in which I eat

103:19

so

103:20

I'm just going to allow myself to eat

103:22

you know from noon to 8 PM or 2 P.M to 8

103:26

PM or 2 P.M to 6 p.m and the narrower

103:29

and narrower you make that window the

103:31

more likely it is that you will induce a

103:34

significant caloric deficit and

103:36

therefore you will lose weight what do

103:38

you think of fasting G fast not anymore

103:40

uh at least not deliberately uh I mean I

103:43

sometimes end up fasting just by the

103:45

nature of whatever I'm doing but um

103:47

again fasting has a lot of advantages

103:49

it's conceptually the easiest by far I

103:52

think it is just the easiest to execute

103:53

on and because for most people it's just

103:56

easy to not eat for a period of time and

103:58

then have no restriction when they are

103:59

eating

104:01

um I think the biggest challenge of

104:02

fasting comes down to protein intake and

104:04

protein is in my view obviously I write

104:07

about this in the book The most

104:08

important macronutrient the one we need

104:10

to be paying the most attention to and

104:13

when you are intermittently fasting

104:16

it is very difficult to get the right

104:19

amount of protein in and in the right

104:22

Doses and therefore it's the most

104:24

difficult to maintain muscle mass and we

104:27

always have to remember that

104:29

you know if we're losing weight we still

104:31

want to be able to maintain muscle mass

104:33

we want to just lose fat mass and not

104:35

lose both I'm fasting as we speak

104:39

um I haven't eaten today yet and it's I

104:41

think it's just after six the reason for

104:43

that is because before this podcast I

104:45

realized that if I eat before I have a

104:47

conversation my brain doesn't work

104:50

it feels like and I'm having spoken to

104:52

some experts the energy rushes to my gut

104:55

so I can't I can't speak as well and I

104:57

can't think as well so I ordered the

104:58

food just before you got here and then I

105:00

said to my sister I can't eat it and

105:02

within an hour of you so I'll eat it

105:04

after but

105:05

yeah and the health benefits are one

105:07

thing but the cognitive impact as well

105:08

has been quite quite big for me

105:11

um

105:12

so you don't fast

105:13

no no I used to fast a lot I mean I used

105:16

to do days and days at a time alcohol

105:18

another thing I wanted to talk to you

105:20

about I'm thinking of quitting

105:23

what is the um what is the advice from a

105:26

doctor like yourself about alcohol and

105:28

do you drink I do

105:30

it's a very interesting topic so I and

105:32

it's so long that I I don't want to I

105:35

don't want to spend another hour on this

105:37

because I'm sure that's not the answer

105:38

anyone is looking for

105:39

I will say this

105:41

um alcohol ethanol which is the alcohol

105:44

we drink is toxic

105:46

um its toxicity is non-linear so its

105:49

toxicity kind of goes like this meaning

105:51

at low levels it's just a little bit of

105:54

an increase but the more you drink the

105:57

more it becomes toxic so

106:00

um you know for most people there's not

106:02

an appreciable amount of toxicity at one

106:04

drink a day but you know two three

106:07

drinks a day starts to become quite

106:09

toxic

106:10

but there is no dose of ethanol that is

106:13

helpful

106:14

so the question becomes why is there so

106:17

much epidemiology out there suggesting

106:20

the benefits of modest alcohol intake so

106:24

there's this thing in the alcohol

106:26

research field called the J curve the J

106:29

curves a picture A J curve for all cause

106:31

mortality it means that at total

106:34

abstinence mortality is here but as you

106:37

drink a little bit the mortality goes

106:40

down before it really Rises sharply as

106:43

you increase the drinking that's what

106:45

the epidemiology shows and it goes down

106:48

well again epidemiology is fraught with

106:51

many limitations especially epidemiology

106:54

of nutrition okay it's much worse than

106:56

the epidemiology of say exercise or

106:57

infectious diseases

106:59

and

107:01

proponents of alcohol argue that and

107:05

they might be right to some extent that

107:07

there are some pro-social benefits of

107:09

alcohol alcohol at least in the form of

107:11

red wine is also potentially something

107:13

that comes with some antioxidants and

107:15

things of that nature

107:17

my view is that that literature is

107:19

highly flawed and that that literature

107:22

is confounded by a negative survivorship

107:25

bias and it's confounded by the fact

107:29

that net that non-drinkers often have a

107:33

health reason for being a non-drinker

107:35

and in other words there are people who

107:37

are completely not drinking because of a

107:40

health reason that's forcing them to be

107:42

not drinking and people who drink and

107:46

die as a result of it dilute the pool of

107:49

data that we have of the toxic effects

107:53

of alcohol As Time Marches forward so

107:56

it's a long-winded way of saying I think

107:59

anybody who's thinking about not

108:01

drinking should absolutely engage in

108:03

that there's no health benefit to be

108:05

drinking

108:06

um you asked me if I drink the answer is

108:08

I do

108:10

um but I don't drink if it sucks like in

108:13

other words

108:15

there has to be a good reason for me to

108:17

drink so my my sort of Mantra is don't

108:19

drink on airplanes like they always just

108:21

have crap alcohol what's the point right

108:24

like if I'm going to drink

108:25

if I'm gonna have a glass of wine it has

108:27

to be really good I don't have a hard

108:28

time opening a bottle of wine that I

108:30

bought and deciding actually I don't

108:32

like it that much and pouring it down

108:33

the sink I'm not gonna drink it because

108:35

it's there

108:36

um

108:37

so that's that's kind of how I think

108:39

about it now there are a couple of

108:41

rules I think that make drinking less

108:43

toxic so rule number one is really try

108:47

not to have more than one drink in a day

108:48

and definitely not more than two

108:51

the hard rule there for me second is I

108:55

do not want to be drinking more than

108:57

three hours or less than three hours

108:58

before bed

109:00

in other words I do not want alcohol to

109:02

negatively impact my sleep which it has

109:04

a devastating consequence of my sleep so

109:06

if I'm going to drink I want I'd rather

109:08

have a cocktail early than drink into

109:10

the wee hours of the night

109:13

sleep's really important to you isn't it

109:14

for sure super important to meso and

109:16

life-changing this little weep thing

109:18

yeah yeah I see that I've actually

109:20

changed my life and you've probably

109:21

noticed how your whoop score changes

109:23

with and without alcohol

109:25

and it's all flashing red and it's the

109:28

first time that happened I had one glass

109:30

of wine and I woke up the next day and

109:31

my my Vital Signs my heart rate

109:33

variability was flashing red and it

109:35

literally says did you have a drink last

109:36

night it changed my life yeah it changed

109:40

my life forever and honestly I'm

109:41

absolutely obsessed with sleep in a very

109:43

healthy way some people think oh that's

109:44

you know you might be waking up and

109:45

feeling bad no I look at it and if I've

109:47

not slept well I'll adjust my day

109:49

accordingly

109:50

um you share some stats around sleeping

109:52

in the book what are what it what is the

109:55

stat or the two stats that changed your

109:57

perspective on sleeping or that really

109:59

you would you would tell someone if

110:01

you're trying to convince them of the

110:02

importance of sleep

110:03

it's so interesting I'll tell you it's

110:04

not even a stat I think it's more of it

110:07

almost goes back to the type of

110:09

discussion you'd have with somebody like

110:10

a Daniel Lieberman right thinking about

110:12

this through the lens of our ancestors

110:14

so

110:15

um I I was always someone who

110:20

de-prioritized sleep

110:23

um you know very busy person uh high

110:26

energy didn't really seem to need that

110:28

much of it even in high school uh was

110:31

sort of always go go and

110:34

um you know at one point I was sort of

110:35

having a discussion with a with a

110:37

colleague about sleep and I was making

110:39

the argument that like I didn't really

110:41

need any of it you know and

110:43

um

110:44

I almost you know made a point like it's

110:46

almost a shame we can't just work our

110:48

way out of it and he sort of posed to me

110:50

in a very Socratic way

110:52

well you know given how

110:56

evolutionarily

110:59

unwise sleep would be right you are

111:03

unconscious for a third of your life and

111:05

me we know that our ancestors slept on

111:08

an average of about seven to eight hours

111:10

every 24 hours they didn't do it always

111:12

straight away but we know that they're

111:15

sleeping basically a third of their life

111:18

um that's a time when you can't forage

111:21

for food you can't defend yourself

111:22

against predators you're not mating like

111:25

there's nothing from an evolutionary

111:27

perspective you're doing those are the

111:28

three highest priorities of evolution

111:30

and you're not doing them why would

111:32

Evolution have kept this thing around

111:34

like and by the way why has no species

111:37

figured out a way out of it

111:39

and I think through that lens I was sort

111:41

of like huh

111:43

yeah interesting maybe this thing does

111:45

matter

111:46

so in some ways I think that's probably

111:48

one of the most powerful things that you

111:49

can hear

111:51

um and sure there are lots of statistics

111:53

about how fragmented sleep broken sleep

111:56

or short sleep can increase your risk in

111:59

particular of cardiovascular disease and

112:01

dementia I think there's a less clear

112:03

relationship to cancer but I think the

112:05

relationship is quite clear to

112:06

cardiovascular disease and dementia in

112:09

addition to insulin resistance and

112:11

obviously therefore weight gain so for

112:13

people even if you're just coming at

112:14

this through the lens of of of weight or

112:18

or excess body fat I mean that's

112:19

probably motivation enough for many

112:21

people and then of course there's how

112:22

you feel and how you perform and your

112:25

creativity and your ability to

112:26

articulate yourself which I notice in

112:28

your mood huge one for me especially

112:30

when you're running teams

112:31

unslept days in my worst days

112:34

um the last thing I wanted to ask you

112:35

about was just again a conversation I've

112:37

had with my friends recently when I say

112:39

my friends I mean this group of my five

112:40

best mates and different voices in in

112:43

the group about hormone replacement

112:45

therapy and one of my friends in

112:47

particular is very keen on it he says

112:49

that when we get older we should all

112:50

take I think testosterone I think it's

112:52

trt

112:54

um because it will help us in all these

112:55

different ways and I've sat here and

112:56

spoken to people about menopause as well

112:58

and

112:59

um the hormone therapy you can take when

113:01

you when you go through menopause what

113:03

is your position on on taking these

113:06

um hormone replacement therapies to

113:08

improve our

113:10

Health span and our emotional state Etc

113:14

yeah I think um it's a long discussion

113:17

but I have a lot of podcasts on this

113:19

topic because I think it's so

113:20

misunderstood

113:22

um

113:23

you know we have a lot of data on the

113:25

use of testosterone replacement therapy

113:26

in men and while I think it is generally

113:29

over prescribed and I think generally at

113:32

least in the U.S men are receiving trt

113:34

far too early in their lives

113:37

um

113:38

I think the the data for responsible use

113:42

of trt uh are very positive so uh the

113:48

risk uh you know again historically the

113:50

risk would be increased risk of prostate

113:52

cancer increased risk of heart disease

113:53

those have not borne out again at

113:56

physiologic doses a very low risk

113:59

proposition that comes with many

114:00

benefits uh most notably of course being

114:03

benefits of body composition but also

114:06

insulin sensitivity

114:08

um I think the cognitive benefits are a

114:10

little more controversial not entirely

114:12

clear that testosterone replacement

114:14

therapy preserves cognition as we age

114:18

but it hasn't been studied perfectly so

114:20

it's I think that's a bit of a TBD

114:22

as far as estrogen and progesterone

114:25

replacement therapy or hormone

114:26

replacement therapy for women I think

114:28

this is unfortunately a very

114:29

controversial topic that shouldn't be uh

114:31

I think it's anybody who's really

114:34

scrutinizes the literature here as

114:36

opposed to just chooses to believe what

114:37

they were told

114:39

um has to come away believing that it's

114:40

a net positive for women especially

114:42

women who are symptomatic right so women

114:44

who are having hot flashes and night

114:45

sweats as they're going through

114:46

menopause they benefit enormously from

114:49

hormone replacement therapy and in the

114:52

case of HRT for women the estrogen is so

114:55

important as it protects their bone

114:57

density so women really go through this

115:00

risk of osteopenia and osteoporosis when

115:03

they go through menopause because their

115:04

bones get weaker in response to estrogen

115:07

loss so being able to restore that is is

115:09

so important and then of course you have

115:11

all of the sexual side effects of

115:12

menopause as well that are ameliorated

115:15

by estrogen another thing that hasn't

115:17

been

115:18

yet completely well studied but I think

115:21

is becoming increasingly of interest in

115:23

the United States is the use of

115:24

testosterone replacement therapy in

115:25

women as well so most people don't

115:28

associate testosterone with women but

115:30

it's actually a very interesting

115:31

statistic that women have 10 times more

115:34

testosterone in them than they do

115:35

estrogen

115:36

it's just that estrogen is the dominant

115:38

hormone for their sexual characteristics

115:42

so we mostly just think about their

115:45

estrogen and progesterone but we should

115:46

never ignore their testosterone because

115:48

a it's ten times more abundant than

115:50

their estrogen even though it's

115:53

1 20th as abundant as it is in a male

115:56

but it still plays an important role in

115:59

muscle mass mood and libido and sexual

116:02

function orgasmic function all sorts of

116:04

things so we think a ton about all of

116:07

these hormones in our patients and um

116:10

I think

116:11

um you know you just have to make sure

116:13

that if you're going down that path

116:15

you're doing it with a doctor who really

116:17

understands it because there are some

116:19

real big mistakes that can get made

116:20

especially in young men who end up on a

116:23

high dose of testosterone and they

116:25

haven't been told that hey by the way

116:27

you know a couple years into this if

116:29

you're on a high dose of testosterone

116:30

you're going to lose the ability to make

116:32

your own

116:33

and you're not going to be able to make

116:35

sperm either really you can imagine

116:37

imagine being 30 having you know some

116:40

Doc in a box puts you on a boatload of

116:42

testosterone and then when you're 35

116:45

you're like yeah I think me and my wife

116:47

want to have kids and you're like nope

116:49

that's not happening

116:52

wow so there's one has to be one has to

116:55

know what they're doing because there

116:56

are ways to give other hormones that

116:58

preserve fertility and things like that

117:00

I'm super scared of all this stuff you

117:02

know I'm super scared of messing with

117:03

the chemical balance of my body uh it's

117:04

my default is is I don't even take like

117:07

what you call it like penicillin if I'm

117:09

if I have excruciating pain somewhere in

117:10

my body I won't take any medicine

117:11

because I'm because I always ask myself

117:13

the question what's the cost there's

117:15

always a cost somewhere and I don't

117:16

think we think about that enough and one

117:17

of the things obviously happening at

117:19

this chapter of my life is my hair is

117:21

going to recede

117:22

and I'm watching as my friends will

117:23

battle this in their own ways some of

117:25

them are doing the testosterone shampoo

117:26

some of them are taking pills for it I

117:29

am I've surrendered it's going back I

117:32

don't care because I'm too scared to

117:34

mess with my chemicals I don't want my

117:35

libido to go I don't want to not be

117:37

opportunity actually I'll just share one

117:39

last interesting story with you so there

117:40

is um the most common drugs that are the

117:43

most common pills that are used for

117:45

treating that are called five Alpha

117:48

reductase Inhibitors so again I don't

117:49

know what their names are in the UK but

117:52

in the in the U.S the two drugs are

117:55

finasteride and dutasteride for receding

117:57

hairlines yeah okay so these are drugs

117:59

that block the conversion of

118:02

testosterone to a more much more potent

118:05

Androgen called dihydrotestosterone DHT

118:09

so testosterone gets turned into DHT by

118:11

an enzyme called five Alpha reductase

118:14

DHT is the hormone that's driving hair

118:16

loss so understandably if you take a

118:20

drug that blocks that enzyme you will

118:22

make less DHT you will have less hair

118:24

loss

118:26

um and these drugs do work but

118:30

a relatively small but not insignificant

118:35

number of men

118:36

who take these drugs have awful side

118:41

effects and the scariest part is it

118:43

appears that a subset of those men do

118:46

not

118:47

lose the side effect even if they stop

118:49

taking the drug and the side effects are

118:51

very sexual right so these are you know

118:54

difficulty achieving orgasm loss of

118:56

libido

118:58

um and and you know so it's a very

119:01

controversial topic

119:04

um but I think it's something that we

119:06

definitely want to make sure men are

119:07

aware of when they're taking high doses

119:09

of these hormones

119:11

that is exactly why I'm not taking them

119:13

that is exactly why I'm not taking them

119:15

I'm just always scared I have that

119:16

default man messing with the chemicals

119:17

in my body there's no free lunch in life

119:19

is there your book is amazing

119:22

um your book is really really amazing

119:24

um very very comprehensive you took many

119:26

many many many many many many many many

119:27

years to write it and it's really an

119:29

amalgamation of all of your insights

119:31

your podcasts your your Genius and your

119:33

lived experience and your perspective

119:35

it's a wonderful wonderful book that I

119:36

highly recommend anybody who's

119:38

interested in the subject map we've

119:39

talked about today

119:40

going goes and gets there's so much more

119:42

that we could have talked about in there

119:44

if anybody wants the more and more

119:46

detail and all the stuff we've talked

119:48

about the book is the place to go we

119:49

have a closing tradition on this podcast

119:50

where the last guest leaves a question

119:52

for the for the next guest not knowing

119:53

who they're going to leave it for

119:55

um and I don't get to read it until I

119:57

open the book so the question that was

119:59

left for you by Our Last guest they

120:00

don't know who they're leaving it for so

120:02

um

120:04

this is also the longest question I've

120:05

ever seen in this new age of AI when

120:09

Humanity has logic

120:13

machines that will outlogic humans how

120:17

are you going to help Humanity lead with

120:21

love what is your purpose as a human in

120:25

a world where AI is contributing to life

120:29

hmm

120:32

I think my answer is going to be very

120:34

uninteresting because I have relatively

120:37

low

120:39

um

120:41

expectations that my life will matter

120:45

that much in the new world so I think

120:49

that the most important impact I will

120:52

have is on my kids I think this is

120:55

probably more about the world my kids

120:57

will inherit and therefore I think the

121:01

most important thing I can do is ensure

121:03

that my kids are

121:06

um as well adjusted as possible

121:09

um and as curious as intellectually

121:11

curious as possible and so whatever I

121:15

can do to sow those seeds is probably

121:18

going to have a better impact on the

121:20

humanity of the world than anything I

121:22

would do

121:25

thank you

121:28

thank you so much thank you for writing

121:29

this book and taking giving me so much

121:31

of your time I really really appreciate

121:32

that and you've helped me to answer some

121:34

really important questions in my life

121:35

that are genuinely really really

121:36

important and obviously my job then is I

121:38

go on and do this podcast forever and

121:39

I'm going to continue to harvest all of

121:41

that wisdom and share it with everybody

121:42

and and take that forward so thank you

121:44

so much for your generosity there um

121:46

it's an amazing book you have a great

121:47

podcast as well highly recommend

121:49

everyone can check this book out outlive

121:50

by Dr Peter an amazing book thank you so

121:53

much thank you very much really enjoyed

121:55

it

121:56

[Music]

121:58

I'm someone that understands probably

122:00

from doing this podcast the importance

122:01

of having Greens in my diet but do I

122:03

achieve that every week in the chaos of

122:06

my life do I achieve that sometimes the

122:07

answer is no with heels Daily Greens the

122:10

probability of me achieving that is now

122:11

almost 100 because of its convenience

122:14

and because of the ease of preparing

122:16

this one scoop

122:18

10 second Shake

122:20

and you're ready to go this is

122:23

the best product that he'll have

122:25

released in recent times many of you

122:27

will think of alternatives to this but I

122:29

I've tried those Alternatives and none

122:31

of them are as tasty as fuel's Daily

122:34

Greens it was out of stock because of

122:36

the demand it's now back in stock for

122:38

everybody in the USA right now it's not

122:40

available in the UK but when you get a

122:42

chance just try it that's all I'm gonna

122:45

say

122:46

just try it and I think once you try it

122:48

you'll understand why this is such an

122:50

essential part of my life right now and

122:52

will probably

122:54

become an essential part of yours

122:58

[Music]

123:17

oh

Interactive Summary

Dr. Peter Attia, a world-renowned physician in longevity and performance, discusses his philosophy of 'Medicine 3.0.' He argues that current medicine focuses too heavily on reacting to 'slow death' diseases (like cardiovascular disease, cancer, and diabetes) too late, whereas true longevity requires proactive, personalized, and early intervention. Attia emphasizes five core pillars for a longer, healthier life: emotional health, exercise, nutrition, sleep, and the judicious use of pharmacological tools. He shares personal anecdotes about his own journey to overcome maladaptive workaholism and childhood-rooted trauma, highlighting the importance of emotional regulation. Furthermore, he underscores that physical strength and cardiorespiratory fitness (specifically VO2 max) are arguably the most impactful predictors of all-cause mortality, urging people to view discomfort—like resistance training and rucking—not as a crisis, but as an essential part of health maintenance.

Suggested questions

4 ready-made prompts