Insulin Doctor: The Fastest Way To Burn Dangerous Visceral Fat! I'm Finding Mould In My Patients!
3205 segments
If you have a belly, sticking out, you
have a problem. Because the fat that's
in the stomach, that's called visceral
fat. This is very detrimental fat. And
that's the epidemic that we have today.
But the only thing that will make you
lose that fat very quickly is Dr.
Pradeep Jamnadas is a world-leading
cardiologist who has treated more than a
quarter of a million patients with
chronic heart disease. Now, he's using
his voice to help millions more prevent
ending up on the operating table through
simple lifestyle techniques.
>> This is crucial. Glucose actually stops
sticking inside the bloodstream. And the
body pours insulin into the bloodstream
to push glucose out. But frequent
consumption of carbs, sugar, processed
foods is causing insulin to stay up,
which can lead to insulin resistance.
And you're going to be more prone to
heart disease, which is the number one
cause of death all over the world right
now. But this is where fasting comes in.
Because after 12 hours, you start
pulling the fat out. And the first place
the fat comes out of is going to be
visceral fat. But with modern living, we
have lost this physiology of fasting. So
we'll go into that.
>> And there must be certain things which
people aren't aware aren't healthy as it
relates to my cardiovascular health.
>> Yes. So I see that people who overly do
aerobic activity, they end up with more
coronary artery disease than patients
who do short sprints and resistance
exercises. Then there's mold. And almost
70% of homes these days have some form
of mold toxicity in them. But also, one
night of bad sleep, you become insulin
resistant the next day. And there's
calcium supplements, excessive fruit,
white rice.
>> White rice? You'd be surprised how much
arsenic there is in rice these days. I
watch a lot of true crime. People kill
each other with arsenic.
>> Yes. And it will slowly kill you. And
lastly, this is going to surprise you.
I see messages all the time in the
comment section that some of you didn't
realize you didn't subscribe. So if you
could do me a favor and double-check if
you're a subscriber to this channel,
that would be tremendously appreciated.
It's the simple, it's the free thing
that anybody that watches this show
frequently can do to help us here to
keep everything going in this show in
the trajectory it's on. So, please do
double check if you subscribed and thank
you so much because in a strange way you
are you're part of our history and
you're on this journey with us and I
appreciate you for that. So, yeah, thank
you.
Dr. Pradeep Jamnadas,
what is it you've spent the entirety of
your career,
especially the last few decades of your
career, focusing on?
Prevention of heart disease,
which is the number one cause of death
all over the world right now.
You see, the heart is made up of many
parts. So, this is important. It's a
pump, so it's a muscle.
So, you have diseases of the muscle and
it's rampant these days, cardiomyopathy,
weakness of the muscle. Then you have
the arteries on top of the heart and
that's called coronary artery disease,
diseases of the arteries, they block up.
Then you have the valves, the valves
tend to get damaged as well. For
example, aortic stenosis.
And then you have the peripheral
circulation, all the blood vessels that
go to your carotids, your brain, your
legs, and to all the organs of your
body. And then you have microvascular
disease, which is the tiny capillaries,
that they become dysfunctional as well.
>> What's a capillary? Capillary is the
branch of the branch of the branch.
>> Okay, so like the tiny little veins.
>> Tiny ones, yeah. So, when they become
dysfunctional, that organ becomes
dysfunctional as well. So, cardiology
affects all these aspects.
And how long have you been operating on
people's hearts? About 35 years now. And
how many hearts do you think you've
treated?
In excess of 30,000.
And what what's the age range of those
patients?
They we used to be mostly older people,
over 65. Now, I'd say 50% of them are
under 65 and 50% are over 65. So, the
demographics is changing. The younger
people are developing heart disease. So,
the youngest patient you've ever
treated?
28.
And what what was the predicament in
that case? He was having a full-blown
heart attack. So, that means that one of
his arteries was completely clogged up.
It had a blood clot in it. There was no
circulation past that artery, and
therefore he was having acute chest
pain, sweating, blood pressure was low.
He comes straight to the hospital. I
rushed to the hospital, take him
straight into the cath lab, and try to
open up that blockage. And we did open
up that blockage, and we put a stent in
it, and got rid of that blockage
immediately to restore that blood flow
to the heart muscle.
And at 28, how does one get a heart
attack? You said it was blocked up.
There's a lot of nuance in that.
Most people don't understand what a
heart attack is. So, in a nutshell, I'm
going to tell you what it is.
When you have a plaque, a plaque is a
build-up of a little
fibrous material inside the artery,
and that doesn't cause a heart attack. A
heart attack is caused when one of those
plaques
cracks. Now, in this diagram, for
example, it's showing that the plaque is
closing up the artery, and this will
cause angina. That means a lack of blood
supply over here. So, this patient may
complain of chest discomfort, or he may
not complain of chest discomfort.
Because remember, when you have a
blockage like this, only 20% of the
patients actually get chest pain.
That means that you could have a
blockage like this in a patient, and he
may not have any chest discomfort.
And the only way you're going to pick
that up is by doing a stress test, or a
coronary calcium score, or some other
modality to see whether he has blockage
or not. A heart attack is when a minor
blockage, which is not causing much flow
disturbance, suddenly cracks. And what
happens to the the plaque that that
cracks off? And when it cracks open, the
blood that's going past it sees the
crack and wants to repair it
and forms a blood clot on it. So, the
final thing that shuts down that artery
is a blood clot. It's not the plaque
that shuts it off. It's a blood clot.
So, a heart attack is caused by a blood
clot at the site of a rupture. And what
causes rupture is inflammation. Okay.
So, when people say that heart disease
is the number one
killer of people generally that are that
are diseased, is it that process that's
causing it alone or is there a multitude
of processes that lead to heart disease?
There's a multitude of things that lead
to heart disease.
Look, they are That was a heart attack.
That's right. Okay. So,
one, you're making plaque. You shouldn't
be making plaque.
A plaque is an inflammatory
area inside your arteries. It's reacting
to something. And I can go into the
nuance of what's actually What's the
body reacting to? What's inflammation?
Inflammation is reacting to something.
What is that something? And I think it's
important for your audience and
everybody to know what that something
is.
Now, you've got this pimple.
Think of it as a pimple on the inside of
the artery.
Now, one day when there's enough
inflammation in your body systemically,
that pimple is going to crack open, just
like a pimple on the skin breaks open.
Now, that artery has this little pimple
on the inside and it cracks open and a
blood clot forms on it, and that's a
heart attack. So, you don't want plaque
formation. You don't want plaque
instability, which is rupture of that
plaque, and you don't want a blood clot
to form on it. There are factors that
affect each of these processes, and all
three processes are going wrong today.
And that's why we have so much plaque
formation and instability of the plaque,
which then leads, of course, to heart
attacks.
And our blood, in general, we have more
coagulation issues today than we ever
did before, which means our blood,
because of inflammation, is more ready
to clot more easily. So, we having the
perfect triad.
It's a perfect storm. That's why we're
seeing an epidemic of this, and that's
why we're not making a dent in it. Yes,
you can have a plaque rupture and have a
heart attack and we'll put a stent in
you. Okay, that's fine. But what did we
do
to look at the underlying reason as to
why you formed that plaque, and why did
you rupture it, and why was your blood
so clotty in the first place that made
you actually seal off the artery?
Is this an increasing problem?
Yes, it's a it's a huge problem, because
those factors have been identified now.
And that's what we go for in my
practice. We look for the factors. Why
did you make this plaque?
Why is there so much inflammation in
your body?
Inflammation is a reaction to something
foreign. What is that foreign stuff?
What is that abnormal physiology in you
that your body is reacting against?
Because that's what inflammation is.
And inflammation, of course, whenever
there's going to be inflammation,
there's going to be increased tendency
to make blood clots. So, we go in, we
chase all these things in patients to
find out. And that's the real
prevention.
That 28-year-old that came in
um and you treated him, was it was that
a a surgery you did? We call it a
surgery, but it's not. It's a it's a
angioplasty. So, we go in from the wrist
Yeah. or we go in from the groin with a
catheter, and we go into the coronary
artery. A catheter being like a tube
>> It's a hollow tube, and we put it into
the coronary artery. We shoot the dye
inside, we see where the blockage is,
and then we thread a tiny wire
into that artery through the blockage,
and then bring in a balloon, and squash
the blood clot out of the way, restore
the circulation,
and then bring in a stent. A stent is
like a spring that opens the artery up.
We leave the stent inside there, we
remove everything else, and now you have
an open artery, and you have blood flow
going down that artery.
>> And what had that 28-year-old done to
end up in your surgery? What were the
decisions that they had made that
brought them there?
So, he was number one, he was
overweight. But, he wasn't just
overweight. The overweight was all in
his belly.
And he had a fatty liver, and he had
what is known as visceral fat.
He was not a diabetic, but he was a
prediabetic.
That means he had a lot of insulin in
his body, and his glucose levels were
good. So, if you went to his family
doctor, they'd say, "Oh, you're not a
diabetic. Your hemoglobin A1C, which is
a blood test that you do for diabetes,
is actually okay." But, actually that
patient had a very high insulin blood
level.
Now, insulin
is a very atherogenic molecule. It
causes smooth muscle proliferation.
Smooth muscle is in the walls of the
arteries. It causes vasoconstriction.
It makes your blood more clotty,
and it causes inflammation.
So, this patient was a prediabetic.
And this is very important. This is what
caught my attention.
Because when I looked at my patients
that were coming in with heart attacks
and hardening of the arteries, and when
I tried to identify why they're doing
this,
none of them were diabetics.
But, then I did a glucose tolerance test
on them.
And what happened, it was just by chance
that I happened to have these tests in
my office where you can measure the
blood glucose. So, I had about 120 of
them. So, I said, "Look, let's just do
some random testing on these patients."
And I found that at least half of them
had no diabetes, but they glucose
intolerance. That means that their
sugars went up, but not enough to make
them a diabetic. But, it did go above
the normal range. We did not have
insulin testing at that time.
About 10 years later, we started testing
insulin in the office, and I bought a
machine for this purpose
in my office to measure insulin levels.
And life was never the same again. Why?
Because it's all about insulin when it
comes to the metabolic derangement. So,
I found that these patients, their
sugars were going up 250, 160 after
giving them a glucose drink. Mhm.
So, you say, "Okay,
he's not a diabetic. Look, the sugar
didn't really go high." But, when you
measure the insulin level,
the insulin was off the roof. So, when
you say this is an insulin problem, can
you explain this to me like I have no
idea what glucose and insulin are for
for any of my listeners out there that
have a inexperienced understanding of
these these these terms and what they
what they do and mean? It's crucial.
Everybody needs to understand the
relationship between sugar, which is
glucose,
and insulin. When you consume sugar or
glucose, the body has to get rid of that
glucose very quickly from the
bloodstream because glucose actually is
toxic inside the bloodstream. Even
though it is what the body uses for
energy,
in the bloodstream, it glycates all the
blood vessels and the walls and the
components in blood and the hemoglobin
as well. Glycates it. That means the
glucose attaches itself to that
molecule.
So, now that molecule can't work
properly. That is why the higher your
blood glucose,
all your chemicals don't work well. Your
enzymes don't work well. Your hormones
don't work well. Nothing works well, and
you age prematurely because you're
getting glycation. Glyca- A glycated
molecule can't work normally. It doesn't
function normally.
So,
when you consume the glucose, the
glucose has to come out of the
bloodstream. And how does the body do
it?
It sends a message to the pancreas. The
pancreas says, "Aha, I'll make some
insulin." It pours insulin into the
bloodstream. Insulin comes into the
bloodstream, pushes the glucose into the
cells. And where does it push in it?
Into the liver, into the muscles, into
every cell in the body. Insulin will
push glucose out. Now, how much insulin
is the question.
If I'm eating every 3 hours,
and I'm consuming glucose, or I'm
consuming starchy foods, or I'm
consuming carbohydrates. Now, watch
where I'm going with this because you're
already beginning to know where I'm
going with this.
I'm consuming glucose and carbs every 2
3 hours. I'm stimulating my pancreas.
I'm stimulating my insulin. My insulin
goes up, it comes down. But before it
even gets a chance to come down, it goes
up again.
So, the repeated consumption of and
frequent consumption of glucose is
causing my insulin to stay up because
insulin stays a little bit longer in the
bloodstream than the glucose. The
glucose will come down in about 2 to 3
hours, but the insulin stays higher for
about 4 hours. Now, what happens is that
you continue this lifestyle for a few
years.
Now, the body, because these are all
hormones,
will say, "Well, you know, it's I'm
going to need to make more insulin."
Now, you become insulin resistant. Any
hormone that stays in your body for a
long time, the body becomes immune to
it.
So, the next time I eat the sugar, I'm
going to have to make more insulin to
produce the same effect.
That is called insulin resistance. So,
now you got this patient who's been
eating carbs,
sugar,
processed foods.
What does that mean, processed food?
That means foods that are quickly
absorbed into the bloodstream. Processed
foods.
These are products
without fiber.
So, the absorption is very quick. So,
the poor pancreas has to react just like
that. Produces a whole bunch of insulin.
And then the frequent eating and the
frequent consumption makes you insulin
resistant. So, now you produce a whole
bunch of insulin in order to bring that
sugar level down. So, then you say,
"Okay, well, it doesn't matter because
the insulin the insulin is bringing the
sugar level down. So, what's the harm
done?" Because your A1C is still good.
You're not diabetic. No, but it's that
background high insulin that is
destroying your metabolism.
It's that high insulin level in the
background. So, insulin
pushes glucose
into the liver and you develop a fatty
liver.
It pushes the calories into production
of new fats around your viscera. The
viscera means in your belly.
Around your pancreas.
You get visceral fat. Now, this fat is
produced from glucose. It's a different
kind of fat. Look, if I gave you a high
calorie diet right now of all sorts of
foods, you'd put on weight everywhere,
okay?
But, if I give you glucose, you put it
on mostly in your stomach. And your
stomach will protrude. And that's called
visceral fat. It's on the inside. You
can't pinch it. It's on the inside.
>> Around your organs. Around the organs.
This
is very detrimental fat. And that's the
epidemic that we have today. And that's
a direct result of eating, you know,
starchy glucose carbohydrates, which
creates insulin, which creates this
downstream effect on
>> Wrong foods and eating too frequently.
Too frequently, okay. Because remember,
it's also the frequency of eating.
Because before that insulin level gets a
chance to down, you're already popping
yourself with more food. And hence you
develop insulin resistance. You get a
very high insulin. It takes this much
insulin now just to bring that sugar
level down. And then the one day
when you cannot control that sugar, now
that sugar will go out and now your
doctor will say you're a diabetic. But
by that time, you've already had 10
years of hyperinsulinemia.
So, what happens if by the time you make
a diagnosis of diabetes to say Well, now
your sugar is really high. It is high
because your body has not had the
ability to keep it down. Why? Because
even that high insulin could not keep
your sugar level down. You became a
diabetic. You lost that whole
opportunity of prevention. It's those 10
years. Look, by the time you're a
diabetic and you come and see Dr. J in
his cardiac clinic, you already have
coronary artery disease. Like that
28-year-old. The 28-year-old didn't have
diabetes. He already has coronary artery
disease.
By the time you are diagnosed as having
diabetes, you already have coronary
artery disease. We have a great
opportunity here to actually start
screening these patients with insulin
levels very early on. But most doctors
don't have the ability or knowledge to
do the insulin level testing.
But it should be done.
And someone like me, I'm 33 years old
now.
When does the damage begin?
It starts right now.
It starts right now. As soon as you
around 30, you're already starting to
have trouble. You have to But you know,
this is what I do. I look at that
patient walking into my room.
And if I see that he's got a belly
sticking out,
I already know he's probably got insulin
resistance.
Because all the fat is in here.
Because the fat that's in the stomach,
sideways he looks terrible, from the
back he looks great. His waist is
increased. Mhm. Mhm. He doesn't have all
the fat everywhere else in his body.
That's the phenotype of somebody who has
hyperinsulinemia.
That same person goes on a cruise, he'll
come back 5 to 10 lb more because he's
got so much insulin in his body. Insulin
is a storage molecule. Puts everything
away.
And it's very hard for him to lose
weight. Why is it harder? You The only
thing that will make you lose that fat
very quickly is to change your diet, of
course, but you have to do fasting.
Because fasting brings your insulin
level See, this is where fasting comes
in.
So, what does fasting do? Do you mean
fasting or a calorie deficit? Is it Or
is it the same thing in your view?
>> No, they're not the same thing.
They are not the same thing.
You see, when you don't eat, your
insulin levels come down because you're
not stimulating your pancreas anymore.
So, you want to bring your insulin
levels down. The best thing you can do
in the world is to do fasting.
Because there's no Look, if I just
simply cut down on my calories,
then there's a different physiology
that's going to take place in the body.
And when you fast, there's a totally
different physiology. When you cut down
on calories, the body senses that
there's caloric deficit. Your metabolic
rate changes. It actually slows down.
And the body will start breaking down
everything, muscles included. So, you
lose fat and you also lose muscles.
On the other hand, when you're fasting,
it's a different physiology.
Fasting is I've put on fat, now I'm
going to take it out of the bank. Now,
the bank is going to be available for me
to pull out my calories and use it now,
and you start burning the fat. So, in
the first 12 hours of a fast, you take
out all the glucose in the form of
glycogen from your muscles and your
liver.
After 12 hours, you start pulling the
fat out. And the first place the fat
comes out of is going going visceral
fat. That is why fasting benefits you so
much cuz it gets rid of that worst fat,
the fat that is very inflammatory. You
see, if I did a biopsy of your visceral
fat
versus a biopsy of, let's say, a fat
from on your buttock, Mhm. two different
types of fat. One is full of
inflammatory molecules,
the other one is not full of
inflammatory molecules.
One is producing interleukin 6 and tumor
necrosis factor,
and this other fat is not. These are two
different fat storages.
Visceral fat is very toxic. It's very
inflammatory.
And that is why patients who have
visceral fat make all these molecules.
So, when I do the blood test, I see
that, "Oh, you've got so much
inflammation. You've got interleukin 6
is high, tumor necrosis factor is high,
your CRP is running high." And one of
the reasons for this
is not just leaky gut and other things
that I look at, but in your case, it is
also because you have a lot of ectopic
fat. Ectopic fat. Ectopic fat is now
we're realizing is not just only around
the liver and around your pancreas, it's
also around your heart.
So, when we look at the coronary
arteries and we see all those fat around
the coronary arteries, we had a very
nice diagram right there, and you can
see that around each artery,
there's that yellowness.
That yellow is all plaque.
Fat. That's fat around that, and it's
plaque forming. It's plaque forming. It
stimulates plaque. It's inflammatory.
And now we can do CT scans that will
actually detect how much inflammation is
in the fat around the arteries as well.
Ectopic fat is in the
around the coronary arteries, it's in
your liver, and in your pancreas, and it
is very inflammatory. On this point of
fasting, so if you have someone come to
you and they're, you know, they have
that physique where there's a bit more
of that protruding belly fat, you said
that fasting is a much better approach
than just sort of a calorie restriction.
I was looking at some studies that said
research shows that calorie deficits of
any kind can reduce visceral fat, but
fasting will give it an edge because of
the insulin sensitivity stuff that you
talked about as well. What kind of fast
should one be doing? Because there's so
many different names for these fasts.
People do these 40-day water fasts and
they do intermittent fasting. It's a
great question. There are many, many
different types of fasting.
Depending on your goal on
what do you want for that particular
patient? So, if a patient is just simply
looking to reduce his visceral fat, then
I start with 12 12, which means 12 hours
you don't eat anything, you just drink
liquids with no calories in it, and then
12 hours is your feeding period. We
start with that.
And we do that for about 2 to 3 weeks,
then we quickly move to 18 6.
18 6 means 6 hours you get to eat. 18
hours it's only
water, black tea, black coffee, green
tea, no calories. 18 6. 18 6. And then
that's one type of fasting. Now, if a
patient is very overweight, a patient
has diabetes, and your goal is to
reverse the diabetes, the patient needs
to lose 60 lb, then those patients have
a special type of need. For them, I will
take them to a 48-hour fast once a week.
Sometimes I'll go to a 3-day water fast
every 9 days.
Every 9 days you will do OMAD. OMAD
means one meal a day only every day for
9 days.
And then you're going to give me a 3-day
water fast.
Is the same advice applicable to women?
Because obviously they're contending
with
a variety of hormone fluctuations and
estrogen and I know that the the the
female body responds differently to
these kinds of stresses like fasts.
I've been asked that question so many
times from patients as well. Most of the
women can actually handle it.
The only women that cannot are those who
are trying to become pregnant or or they
have um
or they're already pregnant. I I think
that women are not that different when
it comes to the fasting programs. So in
my experience, I've been able to get
women to fast. I just finished a fast on
one lady just now for a 72 days. 72
days. She was terribly overweight. She
had diabetes. She had hypertension. She
had hyperlipidemia.
She was having hip replacements, knee
replacements, joint problems. She had
skin problems. And we fasted her for 72
days. What did she have in those 72 days
in terms of drinks, electrolytes,
coffee? What was she Great question. So
she would have black tea, black coffee,
water.
And in the water once a day, I tell her
to put some electrolytes in there. So
there's an electrolyte called Element T
or sometimes I just tell them to go buy
some Celtic salt and put half a teaspoon
in there. And once a day you take that.
If you get cravings
and you feel really really hungry,
take some MCT oil, a teaspoon, and put
it in your water and you can drink that
as well. I think it's worth saying that
probably shouldn't try this at home,
ladies and gentlemen, because obviously
medical supervision is critical here.
But in the case of that lady, what was
the before and after of that 72-day
fast?
So
diabetes gone.
Blood pressure
normalized.
Weight loss, tremendous weight loss. I
mean, I think she lost about 55 60 lb.
Wow. Okay. And not only did she lose all
that weight, yes, all that weight from
her belly was gone, but even her face,
under the arms. So, when you lose weight
in a fasting program, it's very
different from losing weight when you
are restricting calories. You actually
retract your
your skin. So, you get real changes in
your entire body. These people I had one
patient that fasted for 183 days
under supervision.
Okay. So, he went from 400 lb to 210 lb.
And when he walked into the office, you
would not recognize that he's just lost
all this weight because he did not look
like skin on top of the bones and then
having to have surgery to remove all
that excess skin.
Fasting is a totally different
physiology.
In fasting, you you you you you the body
is doing a whole lot of things that are
very different and we can go into the
physiology of fasting because that's
fascinating. It's a physiology that has
not been used by us. We've lost it. So,
one of the things about modern living,
modern living, we have lost this
physiology of fasting. First of all, why
do we still have that physiology in us?
It's because it's supposed to serve a
purpose
because we're supposed to be fasting and
feasting.
But now we're only feasting all the time
and we're not fasting.
In order to go back to normal,
you should be fasting. Fasting is
supposed to be a normal part of your
existence. That's the way you were
designed, not this modern industrialized
living that we've been doing in the last
fraction of a millisecond in the total
existence of the human race.
We've changed our lifestyles so much,
modern man has, but our genetics and our
physiology has lagged behind. We are
supposed to use fasting and feasting as
part of our normal program, as our
normal physiology. That's why we still
have it. That is why after 12 hours, you
start making some more ketones in your
body. And the ketones come from fat.
You're moving that fat out of storage.
>> What is a ketone?
Ah, ketones. So, ketones are a energy
molecule produced by the liver. How does
it make it? It makes it from fat. So,
the fat gets liberalized and by the way,
the fats only start moving when your
insulin levels are down. So, because of
fasting, your insulin levels are really
low now, okay? Because you've been
fasting, right? So, now the fats start
dissolving. So, you get free fatty
acids. The free fatty acids float into
the bloodstream. Free fatty acids are
fat products. They float into the
bloodstream. They go to your liver. Your
liver converts those into ketones. Now,
ketones are an energy source of the
body.
An alternative source to glucose. So, in
general terms, you are either going to
be running on glucose and glucose
metabolism
or you're running on ketones.
Okay? And so, ketones basically show up
in the when glucose isn't around. That's
absolutely right. So, ketones and
ketones are actually a cleaner fuel for
the body.
And in terms of producing reactive
oxygen species in the metabolism, the
way your mitochondria work, you actually
produce less reactive oxygen species,
which is damaging to your physiology,
when you're in ketones. And ketones are
signaling molecules that also change
your physiology in a number of ways.
Number one, it causes the production of
brain-derived neurotrophic factor.
That occurs under ketogenesis.
Brain-derived neurotrophic factor, which
means that you become smarter.
You're growing new cells. Your reflexes
are better. Your visual acuity is
better. Why? Because nature wants you to
become a better specimen so you can go
out and get your next kill. So, why
don't we all just stay in a state of
ketosis then if it's so miraculous?
Well, that's a great question.
You don't want to be in ketosis all the
time cuz that's not what ketosis what
what our physiology was made for because
then you'll just be burning fats,
burning fats, burning fats all the time
and that's not a good state to be in
constantly either. So, you want to be
able to do both. You're supposed to get
your current account and your deposit
account. You're supposed to go work with
both of them. That's the normal
physiology. So, not only brain derived
neurotrophic factor increases, but also
stem cells. Stem cells are amazing.
And in my patients, of course, I see
that What What is a stem cell? Ah, stem
cells. So, stem cells are We all have
stem cells.
And we all still make stem cells.
And they're produced by the bone marrow.
These are pluripotent cells. Cells made
that will then go out and become
whatever they need to become.
So, they can go out into your
circulation, become a muscle cell, they
can become a retinal cell, a skin cell.
They can transform into anything. So,
what happens then when you break your
fast? Mhm.
You get a surge of stem cells coming out
of your bone marrow. Some of them become
immunocytes. That is why we know that
fasting also boosts your immunity.
People who fast get less infections, get
less sore throats and coughs and colds
and the viruses that are going around.
The immunity is better. The stem cells
are not I'm particularly interested in
the stem cells because of a thing called
the progenitor cells, endothelial
progenitor cells. Progenitor cells are
You see, you're always hurting your
blood vessels, the lining of the blood
vessels and the lining of your blood
vessels have to be constantly repaired
and they
they are repaired by the progenitor
cells. When you do intermittent fasting
and time restricted feeding,
you will produce more, and this has been
shown in numerous studies, more
progenitor cells. And these progenitor
cells go and repair your blood vessels.
So, I would do what Why am I interested
in this? Because I'm a vascular doctor.
I want my blood vessels to constantly be
repairing themselves from the damage
that we do in day-to-day life. So, stem
cell mobilization, brain-derived
neurotrophic factor,
growth hormone. You make more growth
hormone in fasting.
So, when should you exercise when you're
fasting?
At the peak of your fast. So, if I'm
going to break my fast at 6:00 p.m.,
I tell patients to go out to the gym at
4:00 in the afternoon.
But they say, "But doc, how can I do
that?"
You will find that you will put on more
muscle, and you will retain more muscle
as well, cuz you have higher growth
hormone. The fastest way and the best
way to actually increase your growth
hormone production is to do intermittent
fasting. When I start with um Dr. Stacy
Sims, who does a lot a lot of um
work on women's physiology and women's
performance, one of the things she said
to me is that if a woman in particular
tries to do a workout fasted, the body
will break down the muscle
in a woman because she said a woman's
body is much more the hip- hypothalamus
is much more sensitive to changes in a
woman's glucose levels cuz it's trying
to defend against, you know, pregnancy
and you know, all these kinds of things.
So, it shuts down the menstrual cycle if
there's not enough glucose in the blood.
And
and so, she said for women in
particular, you do you do want to have
eat something before you work out or it
will
your body will
take from the muscle. And it will
definitely won't The body is very
sensitive. It won't want to to help you
build muscle if there's not enough
glucose energy in the body. She said for
men, it's slightly different because
we're a little bit more robust, and we
were meant to hunt. So, if we were
fasted, our body is, you know, designed
to
kind of keep up its normal processes to
help us complete a hunt, per se. So, I
guess I throw this question out to you
about about women, exercise, and
fasting.
>> Yeah. I I think that's a great
observation. So, again, it's what kind
of exercise is the woman doing? You see?
Now, there's two kinds of basic
exercises. One is aerobic activity,
and one is uh resistance exercises. And
you can also throw into that
high-intensity interval training. Mhm.
So,
when it comes to the training that I'm
talking about in a fasting state, I like
resistance training.
So, in resistance training, that glucose
issue is not going to become a problem.
Now, if you're going to put that female
patient on a treadmill and make her run
for a long period of time, let's say
you're going to make her run for 40
minutes on the treadmill, I think that
yes, you are absolutely right. You are
going to deplete her glucose, and you
may cause some problems, and then the
muscle will start breaking down. But I
do believe, from all the experience that
I've had with my patients, that when I
tell them to do a hit, which is
high-intensity
interval training,
all the women do just as well as the
men. Because all you're doing is you're
intensely working the muscles, and
you're doing some resistance exercise,
and then you're totally resting as well.
And I see fantastic results with that.
In terms of ketosis,
do you
cycle in and out of a ketogenic diet?
And just for anyone that doesn't know
what know a ketogenic diet is a diet
that's very, very low in carbohydrates.
So,
less than 50 g of carbohydrates a day,
typically.
Do you cycle in and out of that diet?
Yes.
Yes, you have to. Because I don't want
them to stay in a ketogenic state all
the time. So, I do. I do. I do. I tell
them, "Look Look, what is your goal
here? What is your goal? If your goal is
that, okay, I need to lose 70 lb, then
you're going to do this till you get to
your goal. Once you get to your goal,
then you're going to go back to
time-restricted feeding, which means
18:6. So, you'll still make some
ketones, and then intermittently, you
can still do a 36-hour fast.
That means
normal healthy people, you and me, we
should still be doing one 36-hour fast
at least once a month. So, we'll go to
that. We'll go to that.
Fasting must still become part of your
pro- But, you don't need to stay in
ketogenesis all the time.
Remember also that when you are in
ketogenesis, you are
you are also in autophagy.
How much autophagy can you do? That
means you're recycling all your your
particle all your organelles inside your
cells. What does that mean in simple
terms for someone that doesn't know the
term autophagy?
>> So, bottom line is the cell senses
that
there is no new parts coming in here.
So, it takes the redundant
organelles inside the cells
and breaks them down.
Packages them up into these little
packets and exports them out of the
cells. So, these cells, all your cells
in the body, now are functioning at a
much more efficient level.
So, mitochondria
also have autophagy. So, you're getting
new mitochondria, you're repairing your
mitochondria, and you know it's all
about mitochondria, right? Your energy
Mitochondria are those organs
organelles inside each cell.
And we just think of them as only an
energy source. That only are my
mitochondria, they make ATP.
That's not the whole story.
Yes, they produce ATP.
But,
they also produce this thing called
reactive oxygen species.
And thereby, they influence
the metabolism of your of your cell as
well. They send signals. They send
signals to your to your chromosomes. So,
you start producing new proteins. You
start producing
molecules. So, your mitochondria are
very important. If you have old
mitochondria, you're going to have
fatigue, tiredness. But, when you get
mitophagy, one reason why you feel so
good after a fast, because you have new
mitochondria. They are much more
efficient in producing ATP and less
reactive oxygen species. So, you have
mitophagy,
recycling of your parts, cellular
function improves.
Toxins get out of your cells as well.
Toxins.
Do you think there's a
preferable or a best exercise for heart
health? Like, if you were going to say,
"Steven, to make, you know, my my I
think my family has a history of
heart-related issues. One of my my uncle
died from a heart attack. So, I'm very
aware of
my own susceptibility to heart-related
illnesses. I think there's other people
in my family um that have heart-related
issues, as well.
Is there a particular exercise that is
best for the heart? Cuz I'm guessing
resistance training, i.e. training,
might not be the
the number one recommendation for good
heart health.
You mentioned hit. I'm wondering if
that's
Yes.
So, I'm just going to tell you, broadly
speaking, what I see in my practice.
I see that people who do a overly do a
aerobic activity, that means they cycle
100 miles a day, or they're running on
the treadmill for 2 hours at a time
every day, or they're doing a lot a lot
of marathon training all the time, they
actually end up with more inflammation
in the body, and they end up with more
coronary artery disease than patients
who do short sprints, and patients who
do resistance exercises, and patients
who do hits.
So,
in terms of cardiology, you Look, you
need some aerobic training. Why? Because
you want to develop some endurance,
right? You don't want to be running
behind the bus and and get short of
breath just, you know, a few hundred
feet. So, for some endurance you do
aerobic activity. How much aerobic
activity, which is running on the
treadmill, for example, or just
sprinting?
Only about 15 to 20 minutes. That's it.
So, I tell patients, you want to run on
that treadmill, you want to bicycle, 15
to 20 minutes. And then you got to go
into resistance exercises. The
resistance exercises that I have seen
work best in my patients is simple
things. You don't have to go crazy. You
do floor exercises. You use your own
body weight
as resistance. So, you can do the planks
and leg lifts and all these other
exercises. And you can do hit. But they
have to be very specific. So, you
exercise really hard for about 30
seconds to 45 seconds and then you
completely rest for another 30 to 45
seconds.
Okay. And that's allowing your body
to clean up the reactive oxygen species
you just created through that exercise.
Because your rate limiting step in
cleaning up the metabolic mess that you
get when you get too much exercise. It's
a rate limiting step. Your glutathione
production, your superoxide dismutase
production.
These are chemicals that clean up the
metabolic mess that you get when you get
too much activity. That's a rate
limiting step.
So, when you rest, you exercise and you
rest, you exercise, you rest, you are
going to get a cleaner physiology.
With your patients, how many patients do
you think you've treated or worked with
in your career?
Ooh.
That's a
>> to guess into the nearest thousand in
your
>> have to be at least
nothing less than
nothing less than quarter million. How
do you deal with the heartbreak? That's
no pun intended, but I'm saying like how
do you deal with the heartbreak of
watching people's lives
either them losing their life or their
their lives being changed permanently
forever or dealing with the families of
of people who lose their husband or wife
or or son or daughter.
It it is very difficult. Especially when
we've been trying everything and still
things can go wrong.
Based on that, I realized that sometimes
you can do everything to try to extend
life, but you cannot life is still
finite.
We will pass, yes, but we want
better health span and we want a longer
life span. I want to give the patients a
better quality of life also. I can't
make you live forever.
I will see people die. Sometimes they
die in front of me while I'm even
holding their hands. They'll pass away
in the hospital right there.
But what I do want to do
is to give them a quality of life until
then that's going to change. And in all
this education,
it's all so that you can live an optimal
life
and then pass away just like that. Have
you seen many people that made all the
right decisions? They were healthy, they
had a good diet, they were doing
exercise, and they still end up
passing away on your hospital table
because of heart-related illnesses? Yes.
Can you give me give me one such
example?
Typical example, a fellow in the 60s.
His coronary calcium score was over
1,000. So, you know that's a CT scan
that we do
and it looks at calcium on the arteries
of the of the wall. So, all this plaque
that you you you you you showed the the
this yellow stuff here, all that has
calcium in it. So, the more calcium you
have, the more plaque you have.
So, he had a calcium score of over
1,000.
So, sit down and talk with him and say,
"Okay, so tell me, why do you have all
this calcium? No diabetes, no high blood
pressure. Doc, I don't even drink. I
don't do anything. I don't smoke. I
exercise regularly. I go to the gym. And
then the question is, why do you have
all this coronary calcium in your
coronary arteries now?
And
it turned out that ever since he was a
kid, he had a bad microbiome.
And in him I found that that was the
reason why he got it. So he was shocked.
When he left the office, he was totally
shocked cuz he thought that being
constipated and having a bowel movement
every 3 or 4 days
is just normal cuz it was always like
that for him.
Until I dug into it and found out that
he's actually got a lot of GI problems.
And that's what probably caused him to
have inflammation. And that's what's
probably caused him to have coronary
artery disease. That's why he's got all
this coronary calcification.
Yeah. So let's talk about the gut
microbiome then.
You you mentioned earlier that that's
really pertinent in
cardiovascular issues. Can you explain
to me exactly why and how that happens?
The biggest difference between you and
your outer environment is actually your
gut.
Not outside your skin.
It's actually the gut. There's a hundred
trillion bacteria sitting in there. And
there's probably 400 trillion viruses
sitting in your gut.
And they're not just hitching a ride for
you. They are there doing something.
There's a symbiotic relationship between
the gut
and you. They produce micronutrients
which get absorbed into your
bloodstream. If the right microbiome is
not present, you are being deprived of
those micronutrients. For example,
short-chain fatty acids which are a
special kind of uh thing. But also, they
maintain the integrity of the lining of
the intestines.
If the lining of the intestines is
breached,
then bacterial wall products get into
the bloodstream. And the first place
they'll get to is the liver.
Hence, you get a fatty liver.
There are basically three reasons for
fatty liver. Either you're drinking too
much alcohol,
or you get a leaky gut,
or you have too much insulin, cuz
insulin causes the conversion of glucose
into fat, right? So, you get a fatty
liver. When you say leaky gut, So,
that's a leaky gut.
>> Ah, okay. So, leaky gut is when
the microbiome is dysfunctional. The
microbiome that is dysfunctional causes
the integrity of your intestinal lining
to be compromised.
>> Ah, okay.
>> Yeah. So, now molecules that are
supposed to stay in the gut,
dead bacterial wall products, they're
called lipopolysaccharides,
they're supposed to stay in the gut, but
now they get into the bloodstream, they
go up the portal vein,
and up the portal vein, they'll end up
going straight to the liver.
And when they end up in the liver, they
cause that fatty liver. Now, you get
this big fatty liver, which causes a lot
of inflammation. A fatty liver
is an epidemic of this going on today.
At least 25% of the population now have
a fatty liver. And what is upstream from
that? Is it Is it alcohol and all these
processed foods and things like that?
It's basically processed foods,
sugar,
and leaky gut. And of course, toxins,
alcohol being the biggest toxin. Okay.
This is the seat of metabolism.
So, as a cardiologist, I became
interested in this because I found that
if you have a fatty liver, you're going
to be more prone to inflammation,
and you're going to be more prone to
coronary artery disease. When we fix the
fatty liver, we change the diet through
fatty by by changing your diet, and now
you start eating real food and not
processed foods and products, when we
increase the fiber intake so that the
good bacteria start coming back into
your gut, mhm? And when I give you
certain supplements to restore all your
nutrition in your body, then all of a
sudden the progression of coronary
calcium flatlines out. You see, let's
say you came to me for test and I did a
coronary calcium score and it's 500.
And 2 years from now it's 800.
That means, wait a second, something's
not right here, right? Your coronary
calcium should not be going up.
Now, I can't get rid of the coronary
calcium because that's plaque in the
walls of your arteries, but it shouldn't
keep going up because one day it's going
to be 2,000. So, how do I follow how
well my treatment for you is is I follow
the coronary calcium score. And again,
the coronary calcium score is a marker
of the amount of plaques Correct. around
the heart and in the vessels of the
blood. Yeah, in the wall.
>> Okay, so you want low
coronary calcium. Like my calcium score
is zero. You shouldn't have any coronary
calcium in the walls of the arteries.
So, we have the yardsticks now We should
probably We should probably
differentiate between calcium
supplements and the calcium that you're
talking about. So pertinent. Calcium
supplements actually increase the risk
of cardiovascular events. Calcium
supplements should not be taken. The
problem is not calcium supplements. The
problem is lack of D3 and lack of K2.
So, we shouldn't be taking calcium
supplements.
>> Absolutely not. Absolutely. I stop all
calcium supplements on all my cardiac
patients.
And I tell them, you should take vitamin
D3 so you'll absorb calcium better into
your gut and you take vitamin K2 because
vitamin K2 is going to make sure that
you don't get the calcium build up in
the wrong places, in your vasculature
for example. Just to give some context
on the research. Some Some large
observational studies suggest that
high-dose calcium supplements,
which is especially, um, above 1,000 mg
a day from pills, may increase the risk
of heart attack and stroke, while others
find no clear link.
Yeah. Okay.
Yeah, no. I Look, also they advise high
calcium supplements in women to prevent
osteoporosis, for example, right? And
osteopenia. Now, I live in Florida, and
all these young women, they come to me
in their 30s, they all have osteopenia.
And the question is that they've got
calcium supplements put inside the milk,
in the orange juice has calcium in it,
and they're taking calcium supplements,
and why would they And they have
sunshine, and why would they have
osteopenia? And the reason is D3.
You need D3 and K2. That's what you
need. It's a hormonal thing. It's not
the elemental thing.
So, when people are on blood thinners,
do they typically have low vitamin K1?
If you're taking Coumadin, Coumadin is a
type of blood thinner Yeah. that lowers
your your vitamin K1 levels. And it will
also lower K2. So, Coumadin will lower
K2 as well.
So, you will get increased coronary
calcification, and that's been
documented. So, patients who have
who are taking Warfarin, for example, or
Coumadin, have been shown to have
increased coronary calcification because
of the fact that the K2 levels come down
as well as the K1 levels. Both come
down. Both So, you need vitamin K2. And
do you just do supplement that, or would
you get it from dietary? I supplement it
on all my patients because diet comes
from fermented foods. And we don't eat
enough fermented foods to contain enough
vitamin K2.
One of the reasons why I do like my
supplements is because today's food is
not as rich
as it was in the past.
So, we're not eating the variety of
foods, but also we're not getting enough
vitamin K2 in our regular diet. So, if
you want to give me advice then on
having a great gut so that I don't end
up with leaky gut, which will cause all
of these downstream effects, what is
What is the advice you'd give me to have
a perfect gut?
Number one,
lots of fiber.
Because the fiber is going to be eaten
by your bacteria, and you're going to
get a wide variety of good bacteria
eating fiber. If you eat a lot of sugar,
you will get bacteria, too, but they are
the bad ones, the ones that you don't
want. So, you're going to get a
condition called SIBO, for example.
But you want to eat lots of fiber, so
because our diets today don't give us
enough fiber,
I do advise all my patients to take
inulin with FOS. It's called inulin with
FOS. It's a powder, it's a soluble
fiber, and I just tell them to take one
scoop in your water every day, or put it
in your whatever you're going to have,
whatever liquid you're going to have.
Number two,
fermented foods.
The fermented foods will give you not
only the bacteria themselves, because
they are For example, called kefir has
so many different strains of good
bacteria, but they also have the
postbiotics.
What is a postbiotic? A postbiotic, for
example, vitamin K2. It's a product that
the bacteria make.
Short-chain fatty acids. That's a
product that the bacteria make. So, you
want bacteria, you want good bacteria in
your gut, and they will stabilize the
ratio of all the other bacteria in your
gut. So, the keystone species have to
come back into your gut. I was reading
some
research around fiber,
and it says that in the United States,
women are 40% fiber deficient, and men
are roughly 50% fiber deficient. And in
the UK,
we're about 40% fiber deficient.
I don't think people know that. Where do
I find fiber? What What What do I need
to be eating to increase my fiber?
Fiber is found in anything that's
non-processed
because the very act of a processed food
is to take out the fiber so that you can
increase the shelf life of it. So, any
processed food, anything that's
manufactured in a factory, for example,
anything that already comes ready-made,
they've taken the fiber right out of it.
So, you got to eat real food. So, you're
going to eat real vegetables. And that
too, a variety of vegetables. You see,
you're supposed to eat 30 to 40
different types of vegetables a week and
we don't tend to do that. So, you want
fiber from a variety of sources. So, we
got to eat a little bit of all these
different different type of vegetables,
including spices. They all count as one
vegetable. So, that's something I I
stressed to everybody that you got to
have variety. You got to have all these
different fibers because they will
foster the growth of different types of
bacterial species in your gut. What
about lifestyle recommendations for
improving my gut? Things like, I don't
know, stress, uh sleep, exercise.
Anything
>> Sleep is absolutely important. So, the
the the next thing is actually actually
sleep and stress because lack of sleep
causes a change in your gut microbiome.
You got to sleep 7 hours a night. And
cutting down on sleep is going to affect
your entire physiology in your body and
your repair processes and your vagus
nerve and your delta sleep and but also
your gut microbiome. One night you'll
get insulin resistance. One night of bad
sleep, you become insulin resistant the
next day.
If you're changing
If you're changing time zones very
frequently,
the
liver dysfunctions
and the gut microbiome also
dysfunctions.
So, we got to be more cognizant of that.
That lifestyle is very important.
And we have to have plenty omega-3 in
the diet.
If you're starting a business, that
means you're one person doing the
workload of probably about 50 people.
When I first founded this podcast, I had
no idea that I was about to step into
100 different roles that I'd never
trained for. Things like researching and
production and scheduling and branding,
all of it all at once. And this
experience isn't unique to me. But for
millions of founders around the world,
the tool that changes all of that is our
sponsor, Shopify. Shopify now powers 10%
of all US e-commerce, from names like
Gymshark and Mattel, to first-time
founders just getting started. It's like
having your very own design studio,
content creator, and marketing team in
one, with hundreds of online store
templates, AI tools to create product
pages, and easy-to-launch email and
social media plugins. Behind the scenes,
Shopify manages your inventory,
international shipping, and even your
returns.
So, if you're ready to sell, sign up for
your $1 a month trial at
shopify.com/bartlett.
That's shopify.com/bartlett.
$1 a month.
No way.
You talked you talked earlier on about
toxins. Yeah. What do you mean by
toxins, and how what role is toxins
playing in my physiology, in my heart
health, in my gut health?
Yeah. So, and what is a toxin?
A toxin is a molecule
that should not be in your body. You
should not have been exposed to it.
So, let's take a pesticide or a
herbicide. These are chemicals
which man has made
and not perhaps adequately tested it in
in um
in rigorous studies, and yet these
chemicals get into the body. And we know
that many of them are estrogen receptor
disruptors, and that causes inflammation
as well.
So, if you look at pesticides and
herbicides,
we look at plastics,
forever chemicals, for example, PFAS and
other chemical BPA.
These chemicals all disrupt our
metabolism in our body.
And then, of course, mold is a toxin.
And lastly, heavy metals are toxins.
When the gut is not working properly,
you're going to be more prone
to toxicity because the gut bacteria
normally grab a lot of those things and
take them out in your stools. So, when
we look at toxicity, we look at gut
health and the liver health. The liver
is supposed to get rid of a lot of
toxins, but
in today's day and age, because of the
foods that we're eating, the environment
that we breathe, the environment that we
walk out into, we're getting too many
toxins and this poor organ here is
getting overwhelmed and cannot detoxify
adequately. So, when I do a blood test,
urine sample, and a stool sample, I get
a very good bird's-eye view of what's
going on with their ability to detoxify
and which levels are high. And I'm
finding
that many of my patients who have gut
issues and liver issues are very, very
high with not only heavy metals, but
they also have a lot of
pesticides, herbicides, and mold in the
body.
And mold, I'm finding a lot of mold. And
mold and all these extraneous toxicities
cause inflammation. Inflammation is a
reaction to something that your body
shouldn't have. Where is the mold coming
from?
Mold is very interesting. I've only
started researching it in the last 1
year.
Basically,
almost 70% of homes these days have some
form of mold toxicity in them, either
from previous water damage or exposure.
And mold is ubiquitous. It's It's just
about everywhere. And it can reinoculate
you every time you're in that
environment and it causes your innate
immune system
to start reacting to it and causes
low-grade inflammation
in your body.
And when I get rid of the mold, all of a
sudden I'm noticing that the patients
are not only feeling better but the rate
of progression of coronary artery
disease flattens off. I have this uh
steam room in one of my houses and uh I
went in there the other day and I
smelled I could smell it smelled a bit
funny.
And I recognize that smell from when I
was younger as being mold. So I like I
Googled it. I said what what is that
like earthy strong pungent smell in my
steam room? I think what's happened is
part of the like seat has come away from
the wall so it's not sealed anymore and
I think the moisture has got in there
with the water and I think it's moldy
and ChatGPT said to me when I was asking
ChatGPT, said it smell near the like
cracks. Yes. And if you smell it if it
smells really strong near the cracks
then that's mold and I smelled near the
crack and it was really really strong. I
remember thinking oh like so I had I not
known that would have been sitting in
there 30 minutes a day inhaling all of
that strong mold smell.
And from doing this show I've I've
learned that the downstream impacts that
can have on your body and your
cardiovascular health and everything in
between is really really bad. So I
I had a team come over and just uh fix
everything, repair it and do a deep
clean but I don't think people are very
aware of
how mold which is the kind of thing you
think of as like oh the the the bread
has gone green whatever can have a
chronic downstream impact.
>> And also this mold can come in and then
become part of your microbiome. So it
can actually come into your So let's say
you get out of this place
but if the mold is still in your gut or
if it's in your sinuses for example and
you get chronic sinusitis, you're
re-inoculating yourself over and over
again with this mold. And this is an
area of great interest and a lot of
research needs to be done. It is real
and we've known about it for a long
time, but the medical profession as a
general has not really taken this and
run with it, but it is very important.
And we certainly
looking at mold toxicity in our practice
because we find that it is actually more
prevalent than we ever ever imagined
before and we know the chemistry. We
know that it causes a a systemic
inflammatory reaction in the body and
it's reflected in the blood work. We see
that the CRP is up. We see that the
complement levels are high. We see that
the certain ratios of certain
inflammatory molecules are off. So, we
will do want to treat mold.
We want to treat sources of mold
toxicity both in the gut as well as in
the sinuses. And yes, people are
surprised when I tell them that that
affects the cardiovascular health. When
we talk about the clogging of arteries,
why is it that healthy people still end
up sometimes with these clogged
arteries? I think it's because they have
sources of inflammation that we have not
identified. For example, we say, "Oh,
you have no cholesterol, you have no
smoking, you have you you're exercising,
you're not overweight, you don't have
diabetes. Well, then I don't know why
you got all these odds." Well, there's
always if you dig deeper inside, there's
always something. And we'll find the
source of the inflammation. There's
always a reason why you get hardening of
the arteries. What's in that list? In
that list is mold. Mold, yeah.
Leaky gut. Yeah. Huge. Food
sensitivities. Oh, let me tell you about
food sensitivities. So,
another reason for the leaky gut
is that certain foods punch holes into
your intestines in a in a in a sense and
causes a leaky gut. And I've had at
least one patient in the last 6 weeks
that I can remember
who
actually has celiac disease.
And he didn't even realize he had celiac
disease because he had no constipation
diarrhea and he had premature coronary
artery disease and we identified that he
had celiac disease. We cut out all wheat
from his diet and that's going to stop
this inflammatory process from
occurring. See, it's all about
inflammation. We need to get rid of
inflammation in order to get rid of
coronary artery disease. Any source of
inflammation.
Get rid of the source. So, if the
pesticide levels are high, herbicide
levels are really high, get off
that source. Maybe you may maybe you're
living on a golf course and you smell
those chemicals every day. Maybe you
using it yourself in your yard. Maybe
you have toxicity coming from mold as
you mentioned, but we got to find the
source of it. So, a thorough evaluation
of the gut microbiome, a thorough
evaluation
of toxins in your body and a nutritional
status.
Your body is able to work and get rid of
this type of pathology if you have good
nutrition.
We don't have good nutrition today.
Let's talk about nutrition then. So, if
I wanted to end up on your surgical
table, if I if that was my goal,
what would you recommend
that I ate
and yeah, consumed? You should eat
nutrient
deficient
processed
foods
every day.
Give me some examples of of things.
Pringles and
Correct. So, it'll be things made out of
wheat, refined wheat, biscuits, cookies,
cakes,
lots of bread,
basically
fast foods,
foods that come in a box, ready-made
food with labels,
anything that comes in a packet that
you're open up.
Including some of these
that are
high protein bars or some of these
because they have all sorts of other
chemicals in them.
And I would have
lots and lots of um
artificial colorings in my food in all
those processed foods.
Um artificial sweeteners
lots and lots of diet drinks and sugary
drinks. Orange juice? Orange juice is is
on my list because that produces such a
profound increase in my glucose level
and then my insulin spike that I'm going
to get afterwards will cause me to
become very hungry 3 to 4 hours later.
So, yeah. I would not eat real food.
And you'll end up on my table.
Also, alcohol, smoking
>> Alcohol
No fiber because none of those foods
will have fiber in them. None of those
processed foods have fiber in them. Your
patients must
come to you at times and tell you what
they're doing
uh in terms of what they're eating and
lifestyle choices. And there must be
certain things which
very people aren't aware aren't healthy.
You actually mentioned bread.
Yeah.
Is all bread bad? No, not all bread is
bad. Most bread is bad. I don't mind
some sourdough because it's fermented.
So, it's going to get rid of some of
those lectins that are already in the
flour. So, those lectins are gone out
because they've been fermented. So, it's
probably a little bit okay. But again,
not large amounts of it, you know, a
slice once or twice a week is fine.
But really, it's a survival food. Bread
is a survival food, just empty calories.
That's all it's going to do.
>> Is there like a worse bread? Is there
like one bread which is
Yeah, pure white bread, simple white
bread. The simple light white bread is
pure calories, 70 calories right there.
You're talking about just eat 10
teaspoons of sugar instead in one slice.
I mean, it just doesn't make any sense
whatsoever. White rice?
White rice. I
White rice is a staple food of many
people and they cannot live without it.
So, I run into this problem all the
time. So, I tell them that this is what
you're going to do. You're going to
first and foremost soak your rice in
water and then discard the water after
an overnight soak because it contains
arsenic in it and other heavy metals.
You'd be surprised how much arsenic
there is in rice these days.
You see? See the problem we have? Our
sourcing of our foods.
I mean, here is a cardiologist has to
talk to his patients about how to cook
rice.
What is arsenic for people that don't
know?
It's a heavy metal that is found in the
soil and the water. It's in contaminated
soil and water and in this paddy fields
are now full of arsenic. It's a poison,
isn't it? People I watch a lot of true
crime. People kill each other with
arsenic.
It's a very, very strong poison and
it'll slowly kill you.
Is there anything else on that list of
thing misconceptions? Cuz
>> So, so, so the rice has to be soaked,
then you'd get rid of the water, then
you cook it
with lots of water, throw away the rice
again. I mean, the I throw away the
water, not the rice. And then, you cool
the rice in the refrigerator.
And then, you eat the rice the next day
by reheating it. Now, what you've done
is you've created resistant starch.
Now, what's going to happen is that that
rice is not going to have the same
insulin effect in your body and weight
gain effect and changes in your
metabolism because it's now got
resistant starch. Resistant starch means
that those
molecules have all bound to each other.
They don't They resist absorption and
digestion until they get to your colon.
And then, who's going to eat it? Your
bacteria. So, you're basically feeding
the bacteria with your rice. So, if
you're going to have rice, this is the
way you're going to do it. So. Is there
anything else on that list that
people should be thinking about that
they probably consider to be healthy
right now. Yeah, yeah, yeah, yeah, yeah,
yeah. So, it's also what you do to your
food. Look, you take a nice piece of
fish, for example, and if you burn it
and you blacken it really bad,
you're creating what is known as
advanced glycation end products.
You fry something, you're creating
advanced glycation end products. So, let
me define that for you.
If nature does not have the ability on
its own
to take
glucose,
protein, and fat and combine them at
very high temperature.
But you can do it in your air fryer
and you can do it outside in in in you
when you're blackening your food and
over blackening your food, it's called
advanced glycation end products. So,
when you over burn your food, when you
overcook your food, you're creating
these molecules. Now, you're consuming
these molecules and they've been shown
to cause a radical increase in the
inflammation in your body cuz your body
reacts to those products. There's
receptors to get rid of those, they're
called RAGEs, and they get rid of these
products, but you overwhelm them and now
you get inflammation.
And is there any other watch out foods
that
you know, people think are healthy but
maybe if if I was trying to have an
optimally healthy heart, I should avoid?
This is going to surprise you.
Excess of fruit.
Cuz I'm not a very big
follower of fruit. Fruit should be eaten
only in season cuz it has too much
fructose in it. Fructose being the
sugars. Fructose is a sugar and fructose
causes fatty liver.
So, our over consumption of fruit is
another factor
that is contributing to coronary artery
disease and diabetes and fatty liver.
And we think of fruit as being a healthy
thing.
You see? But fruit should only be
consumed really in the fall and in
season and in small amounts. Cuz that
high fructose level really causes major
changes in your metabolism.
So, I'm not too fond of fruit. You can
eat fruit in season, small amounts of
it. But, you know, people go crazy about
fruit.
I mean, I had a patient who was having
mental problems, as well as
cardiovascular disease, and he That's
all he lived on, is fruit. Morning,
lunch, and dinner. And the moment we
stopped that, his health changed
completely. He got so much better.
So, excess of fruit is also no good.
Excessively cooked foods, processed
foods, refined products. And another
one, vegetable seed oils.
So, any food that you prepare or you buy
that contains vegetable seed oils is a
no-no.
Cuz vegetable seed oils are a product.
And if you look at all of them, they're
exceedingly high in omega-6. And the
ratio of omega-6 to omega-3
is what the problem we have today.
We have far too much omega-6, very
little omega-3. So, anything that
contains vegetable seed oils So, I
always tell my patients, get rid of that
vegetable seed oil bottle from your
home.
So, what oil should I use instead? The
oil at home, if you're going to use any
oil, is going to be olive oil,
extra-virgin olive oil for your
for your salad.
And if you're going to do high
temperature, put a small little pat of
butter. Or use a little bit of ghee.
Or you can use a little bit of coconut
oil.
This is a bit more of a different
question, but you said earlier on that
when a patient walks into your office,
you can kind of look at them
and generally see if their
cardiovascular health is intact. And
yeah, we're generalizing here. But, if
I'm sat at home right now,
and I'm trying to figure out if I'm
healthy
as it relates to my cardiovascular
health, what are the symptoms of
cardiovascular poor health. Like what
throughout the whole body? What what
should I can I sort of obviously don't
want to anyone to self diagnose at home,
but what kind of symptoms should I be
looking at when I just you even when you
look at me. Let's do this on me to make
it easier.
>> Yeah. So number one, look at your
weight. Okay. If you are overweight,
that's a that's a
that's one strike against you already.
Number two, if you overweight, where is
it? It's mostly on the belly? I'm
overweight according to the BMI.
But again, you got to look at
BMI, you know, is a little crude. It's
not a very accurate way of actually
looking at it because some people are
very muscular and the BMI of 28 is
actually perfectly okay for them. It's
the constitution I look at and it's
visceral fat. Now I can't measure your
visceral fat by looking at you, but I
can tell if your belly is protruded. Now
in my office, I do visceral fat
analysis. So what else I I I don't have
a protruding belly per se.
Um
what else should I be looking for to
understand if my cardiovascular health
is intact. Is there I know
Just by looking at you physically? Yeah.
No, I think that's it basically is your
BMI and your overall weight and must not
have a belly. Just don't have a belly.
If you have a belly, you have a problem.
And what about my joints and stuff like
that? Is that an indicator of Yes. If
you have joint now symptoms, if you
having joint pains, look, if you having
joint pains, people think oh it's just
degenerative joint disease.
In my experience, what I have seen, it's
all inflammation. Because when I change
the diet, when I fix the gut issues,
when I fix
the inflammation in the body, they all
come back and say the joints got better.
All of them uniformly. Especially
patients who have autoimmune disease.
For example, many patients have
rheumatoid.
And the moment we change the diet, the
lifestyle, the frequencies of eating,
introduce a little bit of fasting. So we
do everything, right? Right? We've
changed the gut microbiome. We've we've
made the liver better by by by giving
them some supplements. We do
intermittent fasting. We do some
exercises. We give them some stress
management. We improve their sleep. All
of a sudden,
the joint pains get better. Rheumatoid
gets better. Skin diseases get better.
Psoriasis gets better. Cuz it's the
fundamental underlying part is all
inflammation. This is a random one, but
I'm just connecting dots from different
podcast guests I've had on the show.
What about bad breath?
Bad breath?
Bad breath is real.
But what is it is my oral microbiome
linked to my heart health? Yes. There's
a There's a microbiome that goes all the
way from your nose, mouth, all the way
down to the anus. And each one is
specific and can predict whether you're
going to get cardiovascular disease or
not. There's
unequivocal data to show that if you
have bad teeth, bad dental hygiene, bad
bacteria in your mouth, you're going to
get valvular disease such as aortic
stenosis, premature calcification of
your aortic valve, and you're going to
get coronary calcification. That's been
proven unequivocally. Patients who have
chronic sinusitis in your So, you think
that that's benign? If you have chronic
sinusitis, What's chronic sinusitis?
Chronic sinusitis, infections inside
your maxillary sinuses, frontal sinuses,
constantly, and you get these headaches,
and you get the cold, and your blocked
nose, and you you constantly clogged up
inside here.
That's inflammation. And oftentimes,
that's also linked to premature coronary
arteries and inflammation in your body,
especially when it's fungal. There's a
condition called fungal sinusitis.
Again, it comes down to mold. And this
mold, it causes that low-grade
inflammation in your body. And this has
been linked to coronary artery disease.
You see, what's happening is we're
transforming the whole definition of the
causes of coronary artery disease.
We have been so myopic
in our definition of what causes
coronary artery disease.
It's everything. entire lifestyle.
Mental, physical, eating, everything
will affect your coronary arteries.
Everything. Everything con- Do you think
much about
overstimulation? So, I mean really mean
like too much caffeine.
Does does too much caffeine play a role?
And I say this in part because I think
there's been a few times where I've had
like a pre-workout or
too many glasses of coffee and I've got
like heart palpitations and you almost
like feel like you're dying. Yes. Yes,
yes. Caffeine Caffeine is very similar
to the adrenaline molecule.
Now, why would you want to have too much
adrenaline in your body? Because then
you're living in a state of existential
threat
constantly.
And then what happens? You don't get the
offset either, so you don't get the
parasympathetic. You're only in
sympathetic all the time. That's fight
or flight. All the time. So, caffeine
generates that and the physiology it'll
do Look, caffeine is not as benign as we
think it is. Now, there's nothing wrong
with having one or two coffees a day.
That's fine, okay? But I know people who
drink about six glasses or six cups of
coffee a day and and I think that that's
just That's toxicity. You see? That's
toxicity. Too much caffeine. And it's a
diuretic. And a diuretic will cause
intravascular volume depletion and that
also turns on your neurohormonal
activation. So, you become more
sympathetic. You see? So, it's a vicious
cycle. Makes you dehydrated. I was
reading about this earlier because I did
have heart palpitations one day because
I think I drank too much coffee um
and
what I what I see here in the research
says that moderate caffeine
is safe and even heart protective for
most people, but excessive caffeine when
you get, you know, above 600 mg a day
um can
raise blood pressure, trigger
arrhythmias
>> Arrhythmias, yeah.
and stress the heart.
>> Yes. Now, I want to tell you why coffee
is good. It's not good because of the
caffeine. And so, it's not good at all,
"Yeah, I'm getting that caffeine, so
it's good for me. No. Cuz believe it or
not, coffee has a lot of soluble fiber
in it. So, there is some soluble fiber
in it.
And it has polyphenols.
So, coffee has polyphenols, just like
how cocoa has. You know, cocoa, cacao,
85% cacao chocolate. It's fantastic.
It's got soluble fiber. Cuz who's going
to consume the soluble fiber? It's
actually the bacteria. So, a coffee a
day is actually good for you for a
different reason. It's good because it's
good for your bacteria.
Cuz it's getting soluble fiber and it's
getting polyphenols. And all those
polyphenols are consumed by your
bacteria. They They call cacao, don't
they, the something of the heart? My My
girlfriend's quite spiritual and
in her practice, they call it like the
heart medicine, cacao. Cacao, it is.
Because it has a lot of antioxidants and
it has a lot of soluble fiber. So, wait
a second. Is it soluble fiber? Yes,
because that's fostering the growth of
the good microbiome. The good microbiome
is then going to produce postbiotics.
And the postbiotics
are going to give you all the benefits
that you're going to need. So, it's
going to cause less leaky gut, less
inflammation,
and your enteric nervous system, your
vagus nerve Your vagus nerve.
is going to be protected cuz we're
destroying our vagus nerve right now
with the leaky gut. When people get
heart palpitations, I imagine a lot of
them message you because it's quite
scary, isn't it, when you feel your
heart beating?
What is typically going on and when is
it cause for concern if you've got heart
palpitations? Yeah. If you have
underlying structural heart disease
Let's say you have blocked arteries.
Let's say you have a cardiomyopathy, a
valvular disease, and you're having an
arrhythmia, which is palpitations, that
is definitely life-threatening. They
need to come straight to the office and
we need to monitor you and find out
what's going on. But let's say you're
otherwise perfectly healthy, young
person, perfectly healthy, no heart
disease whatsoever, and you're having
palpitations, then it's usually an
imbalance of your sympathetic and
parasympathetic nervous system. You're
too stressed.
It's basically either too much
sympathetic or
not too much sympathetic, but you have
too little parasympathetic. And that is
one thing that I want people to realize
that
if you've knocked your vagus nerve off
because you have a leaky gut or because
of your lifestyle and your vagus nerve
is not working very well,
you will have this imbalance cuz the
imbalance is not with absolute levels.
It's the relative levels of sympathetic
versus parasympathetic. So, for example,
I see a lot of young women in their 30s
and 20s who come to me with tachycardia.
They have a rapid heartbeat all the time
and especially when they stand up, they
get a rapid heartbeat. This is called
postural orthostatic tachycardia. And
when they come to me,
I find out that it's actually the gut. I
fix their gut and the tachycardia gets
better because by fixing the gut, I'm
fixing the vagus nerve. By fixing the
vagus nerve, the heart rates come down.
I've built companies from scratch and
backed many more. And there's a blind
spot that I keep seeing in early-stage
founders. They spend very little time
thinking about HR. And it's not because
they're reckless or they don't care,
it's because they're obsessed with
building their companies and I can't
fault them for that. At that stage,
you're thinking about the product, how
to attract new customers, how to grow
your team, really how to survive. And HR
slips down the list because it doesn't
feel urgent. But sooner or later, it is.
And when things get messy, tools like
our sponsor today, JustWorks, go from
being a nice to have to being a
necessity. Something goes sideways and
you find yourself having conversations
you did not see coming. This is when you
learn that HR really is the
infrastructure of your company and
without it, things wobble. And JustWorks
stops you learning this the hard way. It
takes care of the stuff that would
otherwise drain your energy and your
time, automating payroll, health
insurance benefits, and it gives your
team human support at any hour. It grows
with your small business from startup
through the growth, even when you start
hiring team members abroad. So, So, you
want HR support that's there through the
exciting times and the challenging
times, head to justworks.com now. That's
justworks.com.
I've just invested millions into this
and become a co-owner of the company.
It's a company called Ketone IQ, and the
story is quite interesting. I start
talking about ketosis on this podcast
and the fact that I'm very low carb,
very very low sugar, and my body
produces ketones, which have made me
incredibly focused, have improved my
endurance, have improved my mood, and
have made me more capable at doing what
I do here. And because I was talking
about it on the podcast, a couple of
weeks later, these showed up on my desk
in my HQ in London, these little shots.
And oh my god, the impact this had on my
ability to articulate myself, on my
focus, on my workouts, on my mood, on
stopping me crashing throughout the day
was so profound that I reached out to
the founders of the company, and now I'm
a co-owner of this business. I highly,
highly recommend you look into this. I
highly recommend you look at the science
behind the product. If you want to try
it for yourself, visit ketone.com/steven
for 30% off your subscription order, and
you'll also get a free gift with your
second shipment. That's
ketone.com/steven.
And I'm so honored that once again a
company I own can sponsor my podcast.
Let's talk about the vagus nerve then.
Um, before we do that, I had a little a
little incident actually caused by
Jemima, who's out there.
Jemima,
we are in this little fitness
competition, and Jemima decided that she
wanted to beat me. And so, she cycled
100 km one day. She cycled for 4 hours,
which meant that she had more minutes in
this fitness competition than I did. So,
my rebuttal
was to do the same, but more. So, the
next day I cycled just over 100 km on my
Peloton at home. Funnily enough, it took
me like 4 hours to do it. And then I
came off the Peloton, I was celebrating,
whatever, you know, won this
gold medal emoji as my reward that
month.
But also I won heart palpitations that
stayed with me for a little while. And I
was wondering like why that happened. So
I did this big vigorous exercise which
was kind of outside of my usual exercise
regime. And then for a a couple of weeks
I could like feel these heart
palpitations.
And is that because of what you were
saying about my parasympathetic vagus
nerve What do you think happened there?
Yes. Yes. Yes. Yes. Over exercise.
This has been shown. When you do what
you just did,
you're diverting blood from your gut to
your muscles. Because your muscles at
that point really need all that blood
supply. And this has been well
documented. So what happens when you
overly exercise like that, you're
causing relative ischemia to your gut.
Ischemia Ischemia, what does ischemia
mean? Lack of circulation to your gut.
So your poor gut at that point had lack
of circulation. Relative. Not to the
point where it's going to go in
gangrenous. No. Don't Don't Don't get me
wrong. But it affects your gut. And in
the gut is the enteric nervous system.
The vagus nerve ends in your gut lining.
And the vagus nerve got affected. So
your vagus nerve didn't work very well.
When you get vagus nerve not working
well, you get too much sympathetic
you're going to get tachycardia. You're
going to get arrhythmias. Palpitations.
So tell me what the vagus nerve is and
what I can do to get my vagus nerve in
check. By the way, Jemima, it was
totally worth it. But just tell me what
I what I can do to get my vagus nerve in
check and like what role my vagus nerve
plays. I've got this photo here of the
vagus nerve.
Um Yeah. You know, the vagus nerve is
fascinating.
It is the largest nerve in the body.
And it it can it basically is sending
messages from the brain
to the whole body and receiving messages
back to say what is the state of
affairs. And the largest distribution,
believe it or not, is all in in gut.
Now that tells you something right there
that
what is the brain most concerned about?
It's most concerned about the most
treacherous border in your body, which
is your gut.
Your gut health is so important that the
body has dedicated a huge nerve called
the vagus nerve just to take care of
your gut.
Because your gut is that important. That
is why By the way, it also has endings
on the heart, in your lungs, in your
face. So, there's lots of endings of the
vagus nerve. And what is it doing? Is it
telling Is it basically the
communication channel between all your
gut, your heart, your brain?
>> affairs. What is going on in the gut?
What should I be doing? Back and forth
traffic information going back and
forth. So, when you when you
the body is supposed to be in a state of
sympathetic followed by parasympathetic.
What does that mean? You run away from
the tiger.
You hide behind the rock. The tiger is
gone now. And now you're supposed to be
parasympathetic.
>> So, sympathetic is the fight.
Parasympathetic is the the relaxation.
>> Rest, relaxation, repair.
Guess what? We're not getting enough
repair these days because we're
constantly in the fight fight fight
fight fight. We never give our chance to
go into repair. That's what the problem
with the vagus nerve that we have today
is. So, we don't get a chance. So, that
is why why don't we do that? Well, one
is our lifestyle. Two, our gut is not
right because it has just made our vagus
nerve dysfunctional. When I fix the gut,
one of the things I notice is heart rate
variability gets better. What does that
mean? Heart rate variability. That means
your pulse
with each breath in
and each breath out, there's a little
variation in your heartbeat. Mhm? That's
called heart rate variability. Now,
when you lost your heart rate
variability, it means that your vagus
nerve is not working very well. When all
patients when I fix their gut, their
heart rate variability gets better as
well.
When you fix the gut, your vagus nerve
will be able to work more efficiently
and you'll be able to repair yourself
after the sympathetic drive. So, you get
the yin and then you get the yang as
well. And the nice thing about the vagus
nerve that I find is that you can repair
it through the gut, but you can also
hack it and you can give it some
nutritional supplements.
The nutritional supplements are omega-3,
which right now 50% of the population is
very low in omega-3, and you need DHA
and omega-3 to to to make your vagus
nerve work optimally. You need to fix
the gut. And thirdly, you can hack the
vagus nerve. So, how do you do that? You
do the breathing exercises. So, when you
do the deep expiration, you stimulate
all those parasympathetic nerve endings
and your heart rate goes down, blood
pressure goes down. What kind of
breathing exercises?
So, breathe in to the count of four,
breathe out to the count of eight. Very
simple. I tell it to all my patients.
Breathe in to the count of four, breathe
out to the count of eight. It's a
deliberately long expiration. You do
that for about 10 minutes a day.
And when you do that, your vagus nerve
is getting stimulated and any nerve that
is stimulated frequently enough will
work more efficiently. What about this
eyeball thing that I've heard you talk
about where you
Eyeball does affect the vagus nerve
function, too. So, when you look to the
right, look to the left at the top, look
down, look left, it stimulates the vagus
nerve. There is a nerve on the ear.
There's also the vagus nerve that can be
stimulated here in the neck, that can be
stimulated the facial nerve also
has branches that go to the vagus nerve.
So, there are a few hacks that people
can use. I even have a small contraption
that I give patients that wear on the
neck and it it it it releases little
signals onto the vagus nerve over here
and I've placed it on patients and they
in front of me and they say, "Oh my god,
I already feel so relaxed and nice." And
it's
I was shocked when they did that.
>> I heard you talk about massaging the
eyeball.
Yes. And cold water on the eyeballs. So,
I don't advise massaging too often, but
cold water and gentle massage on your
eyeballs to release the vagus nerve and
you can do it yourself. You'll notice
that if you're on a monitor and you do
that, your pulse rate goes down. It's
the deep dive reflex that we have in all
of us dive into water. What about
putting an ice pack on the back of your
neck? I think that's fantastic. Back of
the neck, but I would prefer the front
of the neck. Okay. Cuz the front of the
neck is close to the vagus nerve. It's
very close to the karate chief over here
and when you put ice packs on it, the
vagus nerve is stimulated. Humming for
10 minutes? 10 minutes, both sides. What
do you mean by humming? Can you give me
an example?
>> Oh, humming. Oh, humming. Oh, yeah. That
sound is transmitted
to the vagus nerve. So, it's like
shaking that vagus nerve and it creates
electrical impulses
in the vagus nerve. That's been shown.
Singing singing
singing, humming
>> Laughing? You know that there are
laughing clubs?
Maybe you should start a laughing club.
But laughing clubs Yeah, laugh for no
reason. Just sit there and laugh. So,
that diaphragmatic movement that
constant diaphragmatic movement in
laughing stimulates the vagus nerve.
I've heard you talk about this Valsalva
maneuver. Yeah. What's that?
>> The Valsalva is when you breathe in
and then you breathe out, but don't let
the air out and you're straining.
And that straining compresses the
thoracic cavity, but also the abdominal
cavity and stimulates the vagus nerve.
And that is also found to be very, very
very
And remind me again, if I have a healthy
vagus nerve, if I have a
calm, healthy vagus nerve, what is the
downstream impact going to be across my
life?
Downstream impact is going to be faster
healing,
less coronary disease, less high blood
pressure.
Your blood will not be so sticky
and make blood clots, less inflammatory
markers.
The blood test that we do, the
interleukin-6, the tumor necrosis
factor, the CRP levels, small dense LDL.
We didn't even talk about LDL, but LDL,
the bad cholesterol,
all those get better. And what is the
the the role of LDL as it relates to
heart disease? Cuz I've heard this word
cholesterol, I really don't really
understand what it is or I know there's
good cholesterol, there's bad
cholesterol. I know I guess the bad
cholesterol comes from fast food and
processed foods and stuff. But simply,
what do I need to understand about the
role cholesterol plays in heart disease
and how to not have bad cholesterol?
The LDL carries more so of the
cholesterol in the body. It's not
complicated. LDL is what? Is
LDL is a lipoprotein. Yeah. Right? And
you have HDL, which is good cholesterol,
LDL, bad cholesterol, total cholesterol,
and triglycerides. Okay, these are the
four tests.
So, the LDL is a reflection of your
cholesterol. Now,
cholesterol is a normal molecule in your
body.
And you should have cholesterol because
if you don't have cholesterol, I don't
think you'll live too long.
And you need to move this cholesterol
around your body. Every cell in the body
makes cholesterol. Your liver makes most
of the cholesterol, actually.
Now, what happens is that when that LDL
molecule becomes damaged, it becomes a
small dense LDL particle.
A damaged LDL causes inflammation
because now you have a molecule that's
floating around your body. It's been
damaged.
It's small, it's dense.
Now, your white cells, your macrophages,
see that and want to gobble it up.
That's number one. Number two, these
molecules get oxidized in the lungs and
then they the first place they come out
from after the lungs is the coronary
arteries. So, it's the small dense LDL
particles, which are now oxidized. They
destroy the glycocalyx, which is the
lining of the coronary arteries, and
they activate the endothelium.
When they activate the endothelium,
which is the lining of your coronary
arteries, that's when you're going to
start getting atherosclerosis. So,
atherosclerosis and LDL are related, but
it's not the the total cholesterol. It's
when you have small dense damaged LDL.
So, let me explain the impact in my
practice.
Patients come to me because
they either cannot tolerate cholesterol
medications, or they don't want to take
cholesterol medications. What I do then
is I look and say, "Okay, your LDL
is it high or low? Is it Is that what
I'm really concerned about, or is it
that it's small dense LDL? So, I do a
subfractionation." And this is important
for you to understand because they don't
do it in every country in the world, and
it's very difficult to get some of these
blood tests abroad. But in the United
States, it's easy to do it. It's called
subfractionation of your LDL. So, it
tells you whether you have small dense
LDL or not. So, let's say you came to me
and your LDL is 150.
But if it's all made up of large,
fluffy, good, normal LDL,
it's not going to be implicated in your
inflammation or in your coronary artery
disease. I leave that alone.
But if you have small dense LDL, that
also is a problem because it's pointing
me towards inflammation, cuz what causes
small dense damaged LDL are glucose,
omega-6,
advanced glycation end products,
toxins,
and lipopolysaccharides that come from
the gut, leaky gut.
So, now I just gave you the primer
for treating coronary artery disease.
These five things
promote coronary artery disease, and
it's small dense LDL. Those macrophages,
they engulf small dense LDL, and those
macrophages become foam cells. The
endothelium has been
already activated, so they uh
uh bind to the endothelial lining.
>> what is the endothelium
>> The endothelium is the lining of the
artery in your coronary artery. So,
these white cells that are full of fat,
the bad fat, attach themselves to it,
and then become endothelialized. That
means they become part of the wall. So,
they become a plaque.
>> That's Now you got it. That's making the
plaque. You just hit it right on the
head.
So, how would I naturally lower my LDL
without taking statins or any of these
other medications? Is there a way to to
do it naturally?
You You stay away from from meat, yes.
You've gone a vegetarian diet, yes.
It'll come down. But there's no need to.
All meat? All meat, because they all
have cholesterol. Even chicken? Even
chicken. Yeah, if you want to bring it
down. But the question is, do you really
want to bring it down? Do you really
want to bring it down? Later, the most
recent data is very scary. It shows that
patients who have the highest LDLs
actually make it into the 90s
and live a healthier life.
It's not the LDL, it's the damaged LDL
that's the problem. So, this
the medical profession as a whole and
all of us are having a problem grappling
with this. It's Is it the total LDL that
we should be concerned about?
Point to your question. What is a normal
cholesterol?
And should we be lowering cholesterol?
And the answer really is not that
simple. What we should be doing is not
to have small dense LDL. So, the
question is that's the issue. And small
dense LDL are five things. Sugar causes
it, omega-6,
advanced glycation end products, toxins,
and leaky gut. They make your
cholesterol become small dense
particles. A lot of people are concerned
about eating eggs because they think it
might raise their cholesterol levels.
Absolutely no concerns whatsoever. And
what about statins? So, a lot of people
are prescribed statins when they have
heart-related issues. Are they
safe in the long run? Are they
effective? Okay. First part, are they
safe? For the most part, they are. But
at least 20 to 30% of patients will
suffer from sarcopenia, which is loss of
muscles. So, they'll get weakness,
aches, pains.
They'll get diabetes because it causes
mitochondrial dysfunction. So, they'll
they'll do a sugar problems. And many of
them also do develop mental diseases.
So, I've seen that they become forgetful
and they just can't think right and I
stop the statins and all of a sudden
they start feeling better. So, no. Not
all statins are safe.
You need to monitor statins. Also, they
can cause liver dysfunction. So, you
need to watch that. Number two is that
the statins
are they effective? Effective in what?
If the end point is to reduce your LDL,
yeah. Statins will bring your LDL down.
But does that translate to a decrease in
cardiovascular event rates? That's a
totally different question. You see? So,
is your goal just to reduce the LDL or
is your goal to reduce the damaged
oxidized small dense LDL levels?
And when people say they have high blood
pressure,
that's because there's potentially a
narrowing of their blood vessels. So,
the
the the blood has less space to go
through. So, it's kind of like squeezing
a hose pipe that it gets it gets shoots
out faster.
Is that typically what it means by high
blood pressure? Sort of. Let me explain.
When your insulin levels are running
high, all your blood vessels and your
capillaries all don't vasodilate
properly. Oh, okay. And by vasodilation
is the expansion and shrinking.
>> Yeah. So, they don't vasodilate
properly. So, you will get high blood
pressure. So, one of the biggest things
I've noticed with diabetes patients is
when I bring their insulin levels down
through my fasting program and dietary
changes, the blood pressures go away.
See, that's another thing. There's no
such thing as essential hypertension.
Essential hypertension meaning that
you just have high blood pressure.
There's always a cause. Either you have
sleep apnea or you have
hyperinsulinemia.
Cuz sleep apnea also causes
hypertension. So, hypertension does not
always necessarily mean that you're
going to be committed to blood pressure
medications for the rest of your life.
I've heard you talk quite a lot about
breakfast. People ask you about what
they should have for breakfast cuz
everybody wants to know
um how they should be starting their
day.
What is your advice on what we should be
eating for breakfast to have a healthy
heart and cardiovascular system?
Breakfast is a tough one.
I tell most of my patients that if you
absolutely have to have a breakfast,
have a couple of eggs. And if you are a
vegetarian, it makes it a little bit
more tough.
Um but you can have some kefir with two
to three blueberries, two to three
blackberries, and about four blueberries
in it. And then you put your inulin
powder in it, and that's your breakfast.
That's all you should have. But a heavy
breakfast and also breakfast
in my opinion, breakfast should be
should pass breakfast for most adults
and just go for lunch and dinner only.
Cuz then you can do your 18:6. If you
absolutely going to have breakfast, then
you have breakfast and lunch and then no
dinner.
But you got to plan 18 hours. 18 hours
is optimal and we can do it. A lot of
people say they can't do it, but most of
us can do it.
You will notice how much more energy you
have. You know, when I do my OMAD, which
I do at least three to four times a
week, which I only have one meal a day,
at 6:00 in the evening, I actually have
more energy than I do in the morning.
What does your diet look like, doctor?
My diet? Yeah.
I do eat meat, and I do eat fish,
chicken, and turkey. And but I'll have
Yeah, source it right. Always make sure
that it's grass-finished. Always make
sure it's organic. And I have small
amounts of it. Grass-finished,
grass-fed?
Grass-finished. What does that mean?
Grass-fed just means they took it out
one day and put it out in the field.
And they fed it some grass.
So, this advertising that industry does
is a little deceiving.
And I had to investigate this to find
out.
It's a lie. It has to be grass-finished
from beginning to end. So, then it's
going to have more omega-3 in it. It'll
have more K2 in it. It'll have more
nutrition and it'll have less toxins
also in it.
So,
less omega-6. Because if your cows are
eating corn,
then you're going to get all that
omega-6. And the cow is not supposed to
be eating corn.
Cow is supposed to be eating grass.
So, I do eat some meats and I eat some
vegetables with it.
Coming from a background, my
great-grandfather's from India, we do
eat uh Indian food as well. So, we have
some lentils
and some curries, of course. So, we can
cook the meats in a in a curry form as
well. I don't eat much chapatis, because
those are very full of carbs.
I love the taste of it. I love naan once
in a while. And what do you supplement
with? What's your supplements diet look
like?
>> I take D3,
K2,
omega-3, fish oil. So, I take two two
capsules every day. Vitamin C, 1 g,
inulin,
kefir, I drink that every day. And I
count it. Magnesium,
and I take nattokinase.
Nattokinase. Nattokinase, I take about
8,000 units a day. What it is is that
it does thin the blood a little bit, so
that you're less likely to make blood
clots. Part of metabolic syndrome is a
tendency to make blood clots and have a
high fibrinogen level. My fibrinogen
level was at the upper limits of normal,
so I just take nattokinase. It doesn't
cause any bleeding or any problems like
that. And then I also take
a probiotic.
And I it's it's basically is called Mega
Spores
probiotic.
So, this is spores.
There's no real bacteria in there. It's
all spores. What's a spore? A spore, a
bacteria
can survive
by sporulating. So, it becomes a spore,
so it's no longer bacteria, it's a
spore, but it'll germinate under the
right circumstances. So, these little
things, they have they are the spores of
the bacteria that are in soil.
So, soil has certain species of
bacteria, the bacillus species.
The spores
I consume, they go in my gut because
remember, if I take a probiotic,
the acidity in my stomach is going to
kill most of the bacteria.
So, what does the spore do, sorry? Do
you So, the spore passes through the
stomach, goes all the way down to your
intestines, and then it germinates
there. It grows there. So, now the spore
becomes a bacteria. Okay. So, it gets
past that acidity of your stomach. So, I
do take that as a supplement as well.
Dr. J, what is the most important thing
we didn't talk about that we should have
talked about?
For the people at home that have clicked
on this episode. And you know, I guess
one way that you might tackle this
question is just by thinking about the
most popular questions you get asked
from your audience on a daily basis
that we might not have covered today.
How can I screen myself right now? What
test should I do right now to see
at what stage of inflammation and
coronary artery disease am I in? Because
coronary artery disease is the number
one cause of death, and inflammation is
the underlying cause. So, what test
should I be doing right now?
That is an important question. If you
over the age of 30
and you have concerns,
one, get a coronary calcium score.
If your coronary calcium score is zero,
you have no calcium,
then you are in a good place. If you
have coronary calcium,
you need to go see a good cardiologist
that's going to do a prevention program
because it means you already have
atherosclerosis.
Atherosclerosis meaning plaque Hardening
of the arteries.
Number two, you need a good blood test
to look for inflammation. The blood test
that I order is called a Cleveland Heart
Labs.
In it, you get your HDL, LDL,
cholesterol, but you look at particle
sizes.
Is my LDL small dense? If it is small
dense particles, is it oxidized? Yes, I
have a problem.
My CRP level,
other inflammatory interleukin-6,
tumor necrosis factor,
hemoglobin A1C,
sugar level.
All these are part of that panel of
tests. So, you should get a good
inflammatory panel, which is the
Cleveland Heart Labs. So, those are the
two things that everyone must do. Get a
coronary calcium score, all adults,
and do an inflammatory panel.
Inflammation. You got to know whether
you Look, you know
you may not feel inflammation. It's not
like you get a big pimple and it's going
to hurt you. But if you have
inflammation in the body, yeah, you
could know about it. How? You have
mental fog.
I'm not optimal, doc. My memory is going
down. I'm depressed. Depression is
inflammation. Depression is not
something psychological, okay?
Now, this I have to stress to you and I
tell all my patients, you come in and
you say I'm depressed.
You're depressed because
that very symptom of depression is a
symptom of your inflammation.
You can be depressed about something
that oh my car's not working very well.
That's a difference from depression.
Depression is
inflammation in the brain.
So, you'd be surprised how many patients
go on my anti-inflammatory diet, which
is I change their diet, fix them all up,
and the depression goes away.
So, ask yourself not just questions
about physically how you're feeling, but
mentally also.
And if the answer is that doc, I'm not
optimal, I'm forgetful, I'm depressed,
I'm having sleep disturbance, I'm
relation things, man. I've changed. My
body's also changed.
You have inflammation.
We
have a closing tradition on this podcast
where the last guest leaves a question
for the next guest not knowing who
they're leaving it for. And the question
that's been left for you is what was the
most difficult day of your life and how
did you overcome it?
The most difficult day of my life
was a very personal one for me.
You know, when when when
my when my dad passed away and you know,
and I'm Dr. J.
And uh
and when he he was sick and he didn't
want to go to the hospital
and then he passed away in his sleep.
And then you always ask yourself, could
I have done something differently, you
know?
You second-guess yourself. And that
second-guessing happened with him, of
course. It was very very painful.
But it happens with patients as well.
But
how did I overcome it? It taught me a
lot about my own limitations as well, as
a physician, as a son,
as a scientist, as a reader.
And that's why I'm motivated to do what
we are doing here also is to
do the best you can to educate people.
What was he sick with? What was his
predicament?
He was a cardiac patient already. And
he's he's got a very interesting story,
actually. He was told that he only had a
few years to live after he had bypass
surgery. But then I put him through all
the things we talked about today.
He lost a lot of weight. He went from
185 lbs to 135 lbs. He changed his diet,
and he lived another 30 years. And he
did another six world tours, and
traveled, and he had a wonderful life.
Okay?
The impact of simple things that we can
do to change his life. So, he stopped
drinking all alcohol as well, and he he
really had a very clean diet and
everything else. But that night, he came
down with some sort of infection. He had
massive diarrhea and massive massive
explosion. And I think that what really
happened is he got overwhelmed. It's
it's the gut.
He got overwhelmed with a
toxin from his gut.
And then he passed away.
But But here's a man who who lived to
89, was supposed to have passed away in
his 60s.
And the impact But But thing is that,
you know, we
we we shouldn't second-guess ourselves.
We don't want to live in the past.
I want to live in the present moment,
not even in the future.
So,
all these things have taught me to live
in the moment.
And one of the skills I've developed is
just that.
That when I'm with you, I'm only with
you.
If I'm doing your surgery, I'm only
doing your surgery. If I'm having a
conversation with you, you and I are the
only people that matter right now.
And this, being in the moment,
that ability to be that is something I
learned over time. Because before, you
know, something bad happens, your next
case is still reminiscing about that and
you're regretting that. You can't do
that. Life is only expressed in this
moment.
Right now. So, learning how to live in
the moment applies not only to me, but
to everybody.
We all living in the past otherwise.
And or we worried about the future.
So, how do you learn present moment
awareness and live in this moment so
that we will be happier, we can do what
we want to do, make the changes we need
to make, get the courage and make the
and have the willpower to go out and
make a difference to yourself and to
everyone around you, starts with you
being here. Are you here?
Or are you in your past?
Or have you gone off into the future?
That's a skill
that medicine has taught me and I've
become humbled by it.
And this is something
that I have learned.
And I want to pass on to all my patients
to as well. That they okay, you've got
all these things going on, but
learn to live in the moment.
Dr. J, thank you so much. Thank you so
much for the wisdom that you've shared
with so many people. If people aren't
familiar with you, you're extremely
prolific and well-loved across the
internet the
the public education work you've done
and the the heightening of awareness of
people's heart and their cardiovascular
health more broadly and until really
before you started making videos online,
a lot of this stuff was
opaque. It was a mystery to a lot of
people and your YouTube channel has
almost a million subscribers now and you
you go through some of these subjects
that we've talked about today in even
greater detail. So, I'd highly recommend
people go and check you out there, but
also just thank you for saving so many
people's lives cuz
you know, that's what you do day in and
day out and that's an incredibly I mean,
there's probably not a higher calling
one can answer. So thank you for doing
what you do and I can see now why people
love you so much on online and on
YouTube because you're so incredibly
engaging, I guess is the word. Engaging,
wise and you make the information
accessible in a way that
I don't think it's been done before. So
thank you so much. It's a pleasure to
meet you and to have this conversation
with you and thank you for enlightening
my audience. The pleasure was mine.
Thank you.
This has always blown my mind a little
bit. 53% of you that listen to this show
regularly haven't yet subscribed to this
show. So could I ask you for a favor? If
you like this show and you like what we
do here and you want to support us, the
free simple way that you can do just
that is by hitting the subscribe button.
And my commitment to you is if you do
that, then I'll do everything in my
power, me and my team, to make sure that
this show is better for you every single
week. We'll listen to your feedback,
we'll find the guests that you want me
to speak to and we'll continue to do
what we do. Thank you so much.
Ask follow-up questions or revisit key timestamps.
Dr. Pradeep Jamnadas, a cardiologist with over 35 years of experience, emphasizes the importance of addressing the underlying causes of heart disease—primarily inflammation, insulin resistance, and visceral fat—rather than just treating symptoms. He advocates for lifestyle interventions such as intermittent fasting, resistance exercise, and proper nutrition, including fiber-rich foods and fermented products, to optimize cardiovascular health, repair the gut microbiome, and manage toxins like mold.
Videos recently processed by our community