You have an envelope in front of you

there that says confidential on the

front of it. What is in that envelope?

>> It's a paper that's under embargo

because the world thinks it's going to

be very important and it's going to be a

lead article in the frontiers in science

because this is a strategy to manage

cancer effectively and we have a lot of

evidence to keep these people alive a

hell of a lot longer. We have given hope

to the hopeless

>> and you have a perspective on treating

cancer and other metabolic diseases that

others don't have.

>> Yes. But the problem is the field

doesn't understand what I'm saying about

the origin of cancer. So everything

comes back to mitochondria and all

chronic diseases in cancer are the

result of damage to this and the science

is telling us this. But the field of

cancer has yet to accept it. That is a

tragedy.

>> Are you pissed off about this?

>> Well, who wouldn't be? There's 1,700

people a day in this country dying from

cancer. That's 70 an hour. And it gets

worse every single year. When is the

people going to wake up? So give me a

prescription of how I should live my

life to keep my mitochondria healthy.

>> So it all comes down to what you do to

maintain the health and vitality of the

mitochondria that reduce the risk. But

we are now in a new environment where we

have massive amounts of highly processed

carbohydrates, inactivity, emotional

stress, poor sleep habits and you

chronically damage this organel. And

then if you look at the domestic dog,

cancer is the number one killer of the

domestic dog. But wolves in the wild

rarely have cancer. But the wolf is out

running around eating natural foods. Yet

the dog is in an apartment somewhere

gets a dog walker once a day, right? And

the next thing the dog is obese and full

of cancer.

>> And I want to give people actionable

things that they can think about.

>> So this is what's really important. This

is a bioenergetic road map to health.

This is what we call the zone of

prevention. It's very hard to get cancer

or chronic diseases when you're in these

zones.

>> So let's talk about that.

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[music]

[singing]

>> Professor Thomas Seaf Freed, what is it

that you've committed your life to

doing, Thomas?

>> Well, we're right now committed our

lives to managing cancer effectively

uh without toxicity which is based on

based on the science that I and other

others have done in this field.

>> You have a perspective on treating

cancer and other metabolic diseases that

others don't have. the mainstream should

I say.

>> Oh yeah. Well, mainstream doesn't have

it for sure. But it's based on science.

I mean I'm my work is based on what Otto

Warberg the famous German scientist said

from the 1920s30s and 40s. He clearly

showed that cancer was a mitochondrial

metabolic disease.

>> What does that mean mitochondrial

metabolic disease?

>> Okay. It means that the origin of the

disease resides in the organel called

the mitochondrian. It's it's in the

cytoplasm of the cell. It used to be

called still is the the powerhouse of

the cell. Gives the cell the energy.

>> I think we have a mitochondria. Could

one of my team bring in a mitochondria?

>> Well, this is you have a a mitochondria

in here. Oh, here we go.

>> You got one each here.

>> Yeah. Well, see, this is the little

organel that you see. It looks like a

bean shape, but it's actually a tubular

network. These are tubes

>> and they respond dynamically inside the

cell to uh both internal uh activities

as well as external activities. So you

have to realize that at the time of

conception

uh all of the mitochondria for the

developing embryo are in the cytoplasm

from the mother.

>> The cytoplasm

>> the mitochondria are not in the nucleus.

They're in the cytool. Oh, outside of

the

>> outside of the nuke, but in the cell

body itself. So all of the mitochondria,

they determine our destiny. They will

determine how long you will live on the

planet if if you don't have an

unfortunate accident or something like

this. They have an expiration date.

Different species die at different

times. You don't find people living 400

years. Mice live about two and a half

years. Elephants live, you know, as long

as we do or whatever. But that's all

determined by this organel. So you can

see I have wrinkles and this kind of

thing. This is from living on the planet

and this is from wear and tear on this

organel which allows us to make energy

efficiently.

>> So when this organel starts to falter

with age uh you die you die from old

age. This organel has to be protected

and respected if you would like to live

a normal lifespan. But in diets and

lifestyles and way we are today we we we

damage this organel and this organel

then can present itself damage to this

organel which is a tubular network

inside the cell. But let me say

something else. It not only controls the

internal environment of the cell. It

also controls the neighboring cells. The

liver neighborhood the lung neighborhood

the colon neighborhood the brain

neighborhood the gal neighborhood the

neuron neighborhood. But they're all

come from the same origin in that

cytoplasm and they determine the overall

metabolic health of your body. It's a

systemic they communicate

uh with each other across cells across

tissues. I'll tell you this organel

controls [snorts] a lot of what goes

what that nucleus does. It tells the

cell when to divide. It tells the cell

when to slow down.

>> It's kind of like a brain but also like

an engine room.

>> It's kind of like that. Certainly

certainly the brain part of it is really

mysterious uh in the sense of of how it

controls the destiny of the cell in the

body. So sickness

sickness disease cancer what do we know

about the role that this little thing

plays in these chronic diseases and

illnesses and cancers that so many

people suffer with?

>> Yeah. Well, this is the organel that

becomes damaged. Um and it can be

damaged in many many different ways. uh

for cancer is what [clears throat] we

have spent a lot of our time on and now

we've moved into the whole chronic

disease issue because each each chronic

disease can have different

manifestations of ill health to the

mitochondria in a particular population

of cells. But in the case of cancer

which is what we call the most serious

of the chronic diseases creating the

most trauma uh the most emotional

distress but we have clearly shown based

on on many many works that any multiple

things from our environment can damage

this organel in a particular population

of cells in a particular organ. For

example, when you talk about

carcinogens,

it's a chemical that causes cancer. How

does that chemical cause cancer? It

damages the proteins and the lipids.

These little squiggles are delicate

internal membranes. They they contain

the proteins and the lipids that allows

us to generate energy when we breathe.

Okay, you're breathing. I'm breathing. I

take in oxygen. Oxygen serves as a kind

a a final acceptor for electrons that

allows ATP uh to come out of this little

and don't forget it's a tubular network

>> and ATP is the energy currency.

>> It's the chemical energy currency. It

allows us to enzymes to work allow

allows all the metabolic machinery

inside of a cell to work optimally.

>> So just to play this back to you so I

know I'm clear. Oxygen comes in because

I breathe in. I then eat food

>> in in that mitochondria. It does a

process and it spits out ATP as the

energy.

>> Well, and and the waste products of a

good energy metabolism would be CO2 and

water. So, when we burn gasoline in an

engine of a car, we break down the

octane, the carbon hydrogen bonds in an

octane and and we have an internal

explosion that drives pistons. Okay? The

exhaust is a lot of waste products uh

from breaking down the M that we're

doing the same thing inside the cell.

We're combusting carbon hydrogen bonds

and that combustion of carbon hydrogen

bonds is a graded process. So it's not

an immediate explosion. It's a it's a

you're you're breaking down the carbon

hydrogen bonds in a very precise way

producing ATP which then drives the

entire machinery of the neurons and the

rest of the body.

>> It can respond dramatically to energetic

stress, emotional stress. Anyway, I gave

you an example of a carcinogen uh

intermittent hypoxia like people who

have sleep apnea. They stop breathing

for 30 seconds or more in that general

and then they that creates rust RO and

that's what carcinogens do ROS. These

are called reactive oxygen species. They

damage those delicate membranes. And

then what happens if it's too acute, too

stressful, the whole cell will die. the

cell loses its energy and we get uh

apoptosis or necrosis cell death. But if

it's gradual chronic over years, months,

years, this organel

loses its ability to produce sufficient

energy. But the the cell compensates

interestingly enough by using these

ancient pathways heirlooms of our

evolutionary past. So um because all

life on the planet evolved in in oxygen

but without oxygen in the dark uh these

cells grew like crazy. There was no they

were single cells. They unbridled

proliferation and all this kind of

stuff. They didn't have mitochondria.

They had bacteria and the bacteria

which this organel came from was a

fusion between one cell uh that had a

nucleus and and was was fermenting

through the cytoplasm and this bacteria

which is the mitochondria came in and

now you have two different forms of

energy. You have um the energy in the

cytoplasm, the ancient fermentation, and

then you have this new form which can

take in oxygen and generate energy much

much more efficiently than the airlumic.

Listen, one of our big discoveries, if

you can believe it. But you see that

space in the middle there?

>> Yeah.

>> That's called the matrix. And that's

where the KB cycle, the TCA cycle, which

breaks down the food that we eat. But

they have an ancient part of a

fermentation mechanism inside because

before oxygen came every all life forms

were fermenttors. They they produced

energy without oxygen because there was

no oxygen. We had to wait for those

bacteria to make oxygen through a

photosynthetic process. But all

organisms were fermenttors in the

beginning after this organel came in and

was able to take in oxygen make energy

really really quick. But in that matrix

they have a uh in the cycle there's a

little pathway there that makes energy

without oxygen from the evolutionary

past. So we have it in the cytoplasm of

the cell because they can use they can

ferment in the cytoplasm. But this organ

that our big discovery with the work of

of Christounis from semlice university

he's the world leader on that little

pathway. When this organel becomes

impaired,

these ancient pathways of energy through

fermentation arise. Okay, they they try

to replace the lost energy from the

efficiency of this organel. That space

starts throwing out ATP

from glutamine. It's another

fermentation fuel and and it's making

it's making ancient energy in the

sophisticated organel that was that was

that that evolved to make efficient

energy. So let me let me tell you. So

you get you asked me what about damaging

this organel and what happens if the

damage to oxidative phosphorilation

>> what does that mean?

>> Which means energy through oxygen

[clears throat]

>> is too acute the cell will die.

Cyanide is a a perfect example of this.

You take a mouse or a rat or a person

and you drink Kool-Aid, the cyanide

laced Kool-Aid, you die because what

happens is that cyanide binds to the

protein that's going to um um use oxygen

for energy and the whole system shuts

down.

>> Suffocates you basically.

>> Yeah. You die in instantly. Um and there

are other things that can kill uh can

kill uh quickly aid and a variety of

other chemicals but for chronic diseases

it's usually u not an acute stress on

this organel it's a it's a chronic

stress and in cancer what happens in a

particular tissue whether it's bone lung

bladder brain they gradually compensate

with these ancient fermentation pathways

so so this thing this organel cell

signals to the nucleus I'm suffoc I'm

not getting enough energy. Um so the

nucleus turns on the transporters on the

surface of the cell to bring in fuels

that will elevate energy through what we

call uh oxygen independent mechanisms.

This is an oxygen dependent organel.

This gets most of its energy because we

breathe, all of our cells are using

oxygen and the CO2 that we're blowing

out and the water that will be collected

in the form of urine when you might put

uh other waste products in there. That's

efficient metabolic homeostasis. This

organel makes not only the cell but the

whole body in a state of of metabolic

homeostasis where all systems are

working at optimal efficiency. But with

chronic disruption, uh, smoking, uh,

lack of exercise, you can go right down

the list of all of the different things

that can elicit cancer, any kind of

carcinogens, microplastics, forever

chemicals, uh, uh, uh, glyphosate and

any of these kinds of things that would

chronically damage uh, the ability of

this organel to produce energy. Viruses,

ankcoenic viruses, inflammation. you

have chronic inflammation. Any of those

things damage this the sophisticated

ability of this organel to produce

sufficient energy. That's why that's why

um uh the ankcogenic paradox which we

solved.

>> What's the ankcogenic paradox?

>> That was the paradox that was first put

out by Albert St. Gorgi Hungarian

[clears throat]

uh scientist who received a Nobel Prize

I think for vitamin C. He said he said

he was very interested in cancer and

living systems. He said there's a

paradox. He said we know multiple things

in the environment can elicit cancer.

We've identified these ankcogenic

viruses, chronic inflammation,

carcinogens, intermittent hypoxia, rare

rare germline mutations. He said we

don't understand

the common pathophysiological

mechanism by which any of those

provocative agents would elicit

disregulated cell growth which is

cancer. When you talk about cancer, what

do people say what is cancer? It's cell

division out of control. It's

disregulated cell growth. This organel

determines when cells should divide and

when they should not divide. It

regulates the destiny of the cell. So

what happens when this organel becomes

chronically impaired? It falls back on

these ancient pathways, these or or

these or um uh pathways that existed

before oxygen came into the environment

where all the cells were disregulated in

the growth because they didn't have this

regulatory system which is the

mitochondria coming from a from a

bacteria.

>> So let me play that back to you in a way

just so I you know make sure I

understand.

>> I I know it can be kind of deep.

>> Okay. So in this mitochondria here that

I have in front of me, there is an

ancient um because this came from the

>> bacteria

>> a fusion of bacteras a long long time

ago.

>> Yeah.

>> The old bacteria

>> about several billion years ago

>> used to be very selfish and just think

about itself. It used to grow on its own

and didn't communicate with anybody. Had

its own way of growing and multiplying

that was really not um in cohesion with

anything else. That is still in there

somewhere. And although now in its

modern form because there's been that

fusion it grows thinking about the wider

organism

um when it becomes damaged

it falls back on that old selfish way of

growing and sometime and that's kind of

what can cause cancers. So if you if

there's stresses on this which could be

all the car carogenic things you

described then sometimes this falls back

on that prehistoric selfish way of

growing where it doesn't think about the

wider organism.

>> It's close um um in the sense of

thinking we don't know about that we

just know the consequences of what

happens when it falls back on those

ancient pathways. Now here's the

situation.

People knew from Otto Warberg said

cancer is a energy problem in the cell.

This why would the cells start to

ferment and produce a massive amount of

fermentation waste product which is

lactic acid. Even in the presence of

oxygen, 100% oxygen, they're still

fermenting. Why? That shouldn't happen.

Uh when you and I hold our breath or

have a heart attack, let me tell you

something. This is really remarkable and

this is another piece of information

that got us on this whole thing. When

people have heart attacks, uh they stop

breathing, the heart seizes, okay, the

bloodstream immediately fills with these

fermentation waste products which are

lactic acid and the other one which we

now know is suinic acid. Okay. Wow.

These two waste products. Now, if you

don't start breathing in a short period

of time, you're going to be dead.

>> Mhm. And you and what you die because

the neurons in your brain cannot sustain

this kind of fermentation energy for

very long. As soon as you the heart you

you give them cardiac massage and

whatever the guy's heart starts beating

again. The lac the waste products

of lactic acid and suinic acid go away.

They disappear because you're breathing

now. You don't need to ferment when you

have oxygen in the environment. And it's

and the mitochondria can can utilize the

oxygen in the environment. cancer cells

to Warberg said it's the weirdest thing.

These cancer cells um continue to

ferment even in 100% of oxygen. Why are

they doing that? And he speculated that

this organel was damaged. Irre

irreversible damage to the organel

happened in these cancer cells. He

didn't have an electron microscope at

the time. He didn't have the

sophisticated tools that we have today.

So he projected that all on biochemistry

at that time. He was a biochemist and he

said you don't should not produce

fermentation if you have ox oxygen

should shut that off and these guys

should return to a normal metabolic

homeostasis. And he said that's because

there's something irreplace irre

irreversibly damaged in this organel. So

a lot of people attacked him and they

said oh we don't have any evidence for

that. Here's the beautiful thing. Some

cancer cells continue to take in oxygen

and make ATP. Therefore Warberg must be

wrong. Uhhuh. We showed that that we

showed the cancer cell takes in oxygen,

but it's not making energy through ATP

in any great amount. It's using it for

ROS react these radicals that further

damage and cause the DNA mutations that

everybody is chasing. It's all

downstream effects of damage.

>> So what does this what does this mean in

simple terms? Because I'm aware a lot of

my

>> Well, it it means I say, okay, so so I

have disregulated cell growth. That's

ultimately what the problem we're

dealing with. We can't control how these

cells are dividing. We're throwing all

kinds of crazy stuff at them. Trying to

poison or radiate surgically remove

them. We're trying to do everything to

stop this disregulated cell growth.

>> Mhm.

>> So when we look at this organel under

the micro under the electron microscope,

we find these cry are often missing. You

have what they call ghost mitochondria.

You got the shell but nothing inside or

if they're inside, they're all deformed.

So we know there's a foundational

principle in biology. Structure

determines function. If the structure is

abnormal, the function will be abnormal.

This is known to all biologists except

oncologists. They don't seem to

understand it.

>> What's an oncologist?

>> Those are the people who study cancer.

>> So, what are you then? [laughter]

>> I'm a biologist.

>> You're a biologist.

>> Yeah. I mean, when we know that if the

organel is damaged, you're not going to

be able to produce energy efficiently by

oxidative phosphorilation. Okay.

>> I think you're a bit further down the

road, Thomas, than a lot of my viewers

are. for me hearing that there's this

energy engine in my cells that and

there's trillions of them or billions of

them and they also communicate with each

other and when this becomes stressed or

hurt or damaged because of lifestyle

choices that I make energy production

and inefficiency will change and that

could cause this to die or malfunction

in some way that is as for me I go I've

got it

>> okay that's a major step forward now we

build upon that yes now we build upon

that okay so so here's the situation

we've discussed cancer cells all of them

that we have ever looked at have defects

in the number structure and function of

that organel okay I have looked at I

published that big paper where I spent

uh over a year of my time going through

the ancient the well the early electron

microscopy literature warberg didn't

have that opportunity because that

technology was not there for him. So he

speculated that based on the

biochemistry, but I went back and I

looked at these um electron microraphs

of mitochondria in various cancers and

they're all damaged. There is few of

them that risk Christ are gone. I work

with some of the best like Aris Aris

Mendy Marillo uh who is a world leader

in beautiful electron microscopy of of

cancer cells and you can see and and all

the damage uh under his magnificently

beautiful and one we have a couple of

papers but let me tell you something

else Stephen in the cytoplasm these

organels are also in contact with other

cellular membranes like the endopplasmic

reticulum there's a lot of we call

organels inside a cell you have the

nucleus you have the mitochondrian

you you you have loss. There's intimate

contacts between some of the other

membranes, mitochondrial associated

membranes we see and they're also

abnormal when you look at them under the

electron microscope.

>> The ones it's talking to are abnormal.

>> Yeah. The ones you can see the the

mitochondria are abnormal and the

membranes that contact them are

abnormal. Okay. And that intimate

contact

>> uh I'll get into the calcium signaling a

little bit later which controls the

destiny of the cell. Why the cell is

growing out of control? Well, first of

all, it's fermenting. Okay, that means

it's getting energy from sources other

than oxidative phosphorilation. You can

take a cancer cell and and treat it with

cyanide or aid or in absence of and it's

still living. It's still growing because

it's not using

>> the oxygen path.

>> They're not using the oxy falling back

on on on oxygen independent mechanisms

which are called fermentation. So I

understand that to be that there's a

malfunction in a mitochondria which

means that it no longer uses its oxygen

pathway

>> as sufficiently as it should. There's

always some residual level

>> and it finds another way to make the

energy which is how it survives.

>> Yes.

>> And then it stops communicating with the

rest of the cell.

>> Well, it actually communicates with the

nucleus

>> to open up the floodgates to bring in

the fuels that drive this fermentation

energy.

>> It gets more and more greedy. It it has

to because you're you're taking an

organel that produces energy highly

efficiently. Okay. Um like 34 to 36 ATPs

>> with oxygen

>> with oxygen. And now you're you're

trying to replace that with fuels that

give you two uh two moles of energy. Uh

>> so it's inefficient

>> very and then and then you get you get

two out of the in so you're getting

four. So you you you have to take in in

order to make up the efficiency you must

have a tremendous logistic you must have

tremendous supply

>> of

>> of the fuels that will give us energy

>> which are

>> glucose the sugar

>> and the amino acid glutamine

>> okay

>> okay our bodies are loaded with

glutamine that's the most abundant amino

acid in our bloodstream and evolution

provided that for us because if we stop

breathing we use that fuel to keep the

cells alive we our gut is controlled by

glutamine Our immune system uses

glutamine.

>> What is glutamine?

>> It's an amino acid. Okay.

>> Which we make from food.

>> Yeah. Which we can make from food. True.

Or they call essential and non-essential

amino acids. Essentials are from that we

must eat. We must have certain foods

that provide these. Glutamine is

considered a non-essential amino acid.

It's an essential amino acid

biochemically called non-essential

because we can make it from sugar.

>> But basically, it's the most abundant

amino acid in our body. I think I get it

now.

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When we fall, the mitochondria falls to

that prehistoric pathway where it starts

making energy in a really really

inefficient way without using oxygen in

the same way. It starts relying now on

glucose and glutamine um to produce that

energy which is a much less efficient

source of energy. So it gets a bit more

greedy. It needs much more to make the

same amount of ATP which is energy.

>> Mh.

>> So these a cancer cell can be very very

greedy. It's not responding to oxygen in

the same way and they they're a bit more

selfish. they start they start sort of

multiplying without thought of the

broader organism.

>> Yes. Yes.

>> So the question I have is how does this

happen?

>> Malfunctioning of the m what is it that

I've done? You know what I ask this

question?

>> Okay. Well, I Okay.

>> It's because children can get these

cancers

>> or a 90-year-old can get the cancer. And

it doesn't appear to me that a

three-year-old

has necessarily made life choices yet

that could

>> but as I said when you consider forever

chemicals uh that are in the environment

uh things that we have that we use in

our technologically advanced societies

can get through the placental wall and

get these into the ch into these

children's uh organs. Um you know you

have to put it together. We usually it's

a a constellation of things because

don't forget I said carcinogens. Some of

these carcinogens are fat soluble. Some

of these carcinogens can get in and

damage those during early stages of

development. People always say how you

explain brain cancer in in a in a

six-month old baby. Okay. What what did

he what what he he wasn't smoking and

drinking and partying all the time, but

but his the mitochondria and a

population of cells in his brain became

damaged. And that damage then led to

this disregulated cell growth because

the organel controls when cells should

divide and not divide. And then and then

where's the energy coming from? How do

you how do you take a highly

sophisticated piece of an organel and

making energy so incredibly efficient

and now we're using energy.

So uh this organel signals to the

nucleus called mitochondrial stress

response retrograde signaling. The

nucleus acts as a respondent to what

this organel wants. So the nucleus then

ankco genes which that you've heard a

lot about. They open the floodgates to

bring in the glucose and glutamine that

allow the cell to grow in a disregulated

way. So we've as you said they go back

to these ancient fermentation pathways

where there was no regulation because

this organel was not part of the problem

part of the situation the regulation. So

is there what are the lifestyle factors

that are causing this to were

drastically increasing the probability

of this happening.

>> It's not necessarily what the person did

or all cases it's what the person was

exposed to uh that could have elicited

this. That's the ankcoenic paradox. So

uh we have shown uh that inflammation

produces these cytoines when you have an

inflammatory heat in inflammation they

they damage the ability of this organel

to make energy efficiently. Chronic

inflammation is known to be a risk

factor for cancer. Chronic inflammation

intermittent hypoxia carcinogens.

>> What's intermittent hypoxia?

>> It's like the sleep apnea that kind of

thing.

Warberg had clearly shown that

intermittent hypoxia on cells would

damage the efficiency of oxidative

phosphorilation leading to a

compensatory fermentation. So you have

to compensate because let me tell you if

you don't compensate you're dead. The I

mean the cell dies. When we look at the

populations around the world that have

the most prevalence of cancer, it

doesn't appear to be

some of the

countries like Nijer, Gambia, Nepal

consistently rank at the very bottom for

cancer cancer incidents. Conversely,

high-income countries like Australia,

New Zealand, and the United States have

the highest rates of cancer. Why is

that?

>> It's because of our um technology. Uh we

are still paleolithic man and uh our

biology

has allowed us to store energy

efficiently

uh because of times of famine. We are

now in a new environment where we have

massive amounts of highly processed

carbohydrates, inactivity, emotional

stress, we have poor sleep habits. You

you pile all those together with availab

the exposure to carcinogens and whatever

and you chronically damage this organel

and uh [clears throat] in some organs

you can get breast cancer if it's a lung

if it's a whatever it is that organel

becomes chronically damaged in some

populations of cells in a particular uh

in a particular organ and and you can

elicit disregulated cell growth as the

result of that. You know what I find is

in in that in the paper that we have

with the chart uh if you can keep your

mitochondria healthy because don't

forget Paleolithic man our ancestors

from 500,000 years ago uh or modern men

like you said in these countries living

according to traditional ways with

minimal in interference from modern diet

and lifestyle issues have lower amount

of cancer in general and this is what

Albert Schwitzer found the the famous

humanitarian physician. He was

specifically looking for cancer in

African tribes and he said remarkably

it's extremely low. What what are these

guys doing where western society has has

a lot of cancer and these Africans have

living living according to the

traditional ways. So they have a lot of

exercise. They're eating all organic

foods. Uh they're not under the same

kind of stress or exposure to chemicals

that modern societies have. And you find

out you have very low cancer. Like for

example, uh dogs are all evolved from

the wolf. Uh wolves in the wild rarely

have cancer. The domestic dog, cancer is

the number one killer of the domestic

dog. What is the dog doing that the

wolf? The wolf is out running around

eating natural foods. The dog the dog is

in an apartment somewhere gets a dog

walker once a day, right? And the next

thing the dog dog is obese and full of

cancer. So it all it all comes down to

what what you do to maintain the health

and vitality of the mitochondria that

reduce the risk and that's what this

chart I'll show you has reduce the risk

of damaging this chronically. Okay. So

that can explain in large part why

modern societies are struggling with

chronic diseases not only cancer we have

diet type 2 diabetes we have obesity we

high blood pressure we we have a whole

even neuroscsychiatric problems. If you

can protect and keep this organel

healthy, you reduce risk. Now people

say, well, cancer has to be genetic

because we have inherited genes that put

us at higher risk like the Bracka one

for breast cancer and the leaf ramen for

variety of other cancers. Our paper in

this pile done by Bob Kaplan uh he went

through uh and looked at all the genetic

risk.

>> Which paper is it?

>> Um it's one of the ones published in

oncology. But none of these mutations

are 100% penetrant, meaning that they're

secondary risk factors. A primary risk

factor would be every time that mutation

is there, 100% of the people because I

work in Tesax's disease. I work in

inborn errors of metabolism. Those

mutations are 100% responsible for that

condition. There's no gene mutation

that's 100% pen. You have that gene,

you're going to 100% get cancer. Uh most

of them are are uh um are what they call

incompletely penetrint. So what does

that tell us about the nature of

>> well it tell and then we went back what

Bob did is he went back and he looked at

what every one of those gene mutations

in some way disturbs the efficiency of

oxidative phosphorilation in that

organel

>> in the mitochondria

>> in the mitochondria we we looked at we

have all the evidence all the risk

factor all the genetically just just the

front page there I was going to show you

the hard data but you got [laughter] so

anyway that all of them damage this the

efficiency of energy through through

through this organel. So that's like

carcinogens, that's like um viral

infections. The viruses that like

hepatoma and papilloma, they they their

their products will go in here and

damage it or they will replicate inside

this organel, screwing up the

efficiency, causing a compensatory

fermentation, causing the disregulated

cell growth through abnormal calcium

signaling, causing cells to no longer uh

be responsive to their neighbors. Is

that clear? If I can make you understand

this, we can make everybody understand

this.

>> Yeah. So, the the reason I uh spend a

lot of time asking why and asking for

clarification is because when I do the

show, I then go out into the real world

and I meet the people that listen.

>> Yeah.

>> And one of the groups of people that

listens are young offenders. And when I

went and visited them, I pointed at the

episodes that I thought would help them.

Yeah. And a young one of the young

offenders said to me, "I can't listen to

that episode because the words you used

were too big."

>> And I remember thinking to myself,

>> "Okay, that I get that all the time, but

guess what? Now we have AI and you can

take this statements and put it into AI

right on the and and it'll it'll it'll

dumb it down for you.

>> So So that's a tool that we previously

did not have.

>> So So I use that all the time. I said

when you hear me speak like this, don't

think I'm arrog

I I I these are the terms that we use

when you're part of the academy. Yeah.

>> Okay. But we can take those terms now

and AI can do a wonderful job in in in

synthesizing. Oh yeah, I know what he's

talking about now. But without that

tool, then it becomes like you said,

well, I can't understand anything.

>> I've got 60 seconds and I'm going to

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Big opportunity. I am not kidding. Give

it a try. I really want to just make

sure I tick off the box of um cause

factors. So you mentioned stress,

>> you mentioned sleep.

>> I currently don't have cancer as far as

I'm aware. God forbid. Um but I but I

want to do everything I can to prevent

the probability. Yeah.

>> And I from what I've understood that

means protecting my mitochondrial

function.

>> Yes.

>> By living a lifestyle where I'm not

creating this sort of like crazy

oxidative stress on the mitochondria.

>> Right.

>> So give me a prescription of how I

should live my life to keep my

mitochondria healthy.

>> Well, that's why we developed the

glucose ke ketone index calculator. the

first biomarket tool that can allow

people to know the level of health of

their mitochondria because

um when you shift from carbohydrate fuel

to lip lipid fuel,

>> what's lipid fuel?

>> Fat.

>> So ketones,

>> ketones are a water- soluble breakdown

product of fatty acids. [clears throat]

>> Okay. So we store atapose tissue. We

store fat

>> which is the belly fat

>> all over. We have fat on our

>> on the outside.

>> Yeah. So on the outside that was there

because as a species we had to survive

in the most harsh environments and we

were um food was not always there. So we

had to survive all kinds of famine all

kinds of absence of food. Our bodies are

so our it's a machine that was home over

millions of years to be super efficient.

So glucose is gold sugar. Okay. You

either burn it or you can store it as

fat. Okay, that's that's the key. But

when you have you're not bringing in

sugar, that stored fat now moves into

the bloodstream, goes to the liver, and

it's like taking a branch and putting it

in a chopper and you outcome these

little soluble ketone bodies. They're

breakdown products of longchain fatty

acids. They can replace sugar for the

brain, for the muscles, for most other

cells in the body except ariththraittes,

but they can replace they can replace

the energy of glucose. Okay? So, uh, and

that's how we evolved. But we're now in

an environment where we have massive

amounts of highly processed

carbohydrates and we we don't want to

pee them out unless you have diabetes or

something. So, we store them as fat. So

we have an obesity epidemic as the

result of our evolutionary ability to

store energy which kept us alive as a

species because if we were unable to

store the fat in 500,000 we would have

all been extinct. You and I this

conversation would never exist.

>> We would never have existed as a species

except for our ability to store energy

and we burn energy efficiently in these

organels. So this is all a very highly

efficient machine. So when we lose that

ability, uh when we have so much energy

in the environment, stress, no exercise,

all this, we store more and more fat, we

produce an an environment that's very

damaging to this organal.

>> Well, say that again. So how does stress

impact that?

>> Stress elevates corticosteroids. When

you're under stress, you get into a

fight, you get into an argument, or

you're stressed out by business deal

going bad, whatever. uh corticosteroids

elevate elevate blood sugar contributing

to uh systemic inflammation. It's okay

for a short period of time to be pissed

off at something. But it's the chronic

stress, the chronic like looking at the

cell phone, doom scrolling, all this

kind of crazy stuff while eating the big

Twinkie, doom scrolling, eating

Twinkies, not moving. All of this

creates uh stress on this organel in

some population of cells.

>> It makes it work harder. It's damaging

because you produce reactive species

that damage the efficiency of this

organel to produce energy effectively

and that either will kill the cell

gradually if it can't comp use

compensatory fermentation or predispose

you to cancer. So either way is

unhealthy. So we have chronic disease.

Cancer is the number one big dog in the

chronic disease world. I mean it's the

one that people fear the most. um type

two diabetes, cardiovascular disease,

you know, dementia, uh all of these are

part of damage to this organel in one

way or another. In like I said for

Parkinson's disease, when that organel

gets damaged, the cells of the

substantion aigrate die. They are

incapable of compensating with

fermentation. So they up and die. Cancer

is very rare in neurons of the brain.

Neurons the gal cells of the brain form

these brain tumors mostly but neurons

[clears throat] can't compensate with

fermentation so they die. So you you

either get comp compensatory ancient

fermentation leading to disregulated

cell growth which we call cancer or we

get cell death leading to chronic

diseases.

>> What about sleep then? What's going on

with sleep that's causing

>> sleep is a way we can restore the energy

efficiency of the mitochondria

>> if we're well slept.

>> If we have good sleep. Yeah. You know

everybody feels good when you have a

good night's sleep. your body feels

rejuvenated because you're not you're

not stressing out. You're reducing the

ability of this organel to manage the

the the the metabolic uh environment. uh

if you're up all night and you're and

you're like stressed out and you're

never given this uh organel in a

particular cell in a particular part of

the organ of the body, you know, you you

get neuroscychiatric problems, you can

get digestive problems, you can get

cancer, you can get type 2 diabetes, you

have a whole and we put it in the paper

there, all the different stress, all the

different things that can chronically uh

or acutely damage oxidative

phosphorilation.

>> So sleep basically gives the

mitochondria a little bit of a break.

Yes. It's a it's it gives your whole

body a break, let's be honest. So, so,

but you you pile those things on

together. Lack of exercise. Our

ancestors, what do you think our

ancestors, you know, how hard it is to

run down and kill a big buffalo or a

woolly mammoth? I mean, you're you're

exhausted after doing something. As a

matter of fact, you chase these animals,

uh, you separate. And this is another

thing that was really interesting. Came

out of Israel. I think it was last year.

They looked at the cavemen, what they

were eating. they were eating the the

strongest members of the herd uh leading

to the indirect extinction of these

animals. They found out that if you can

eat the strongest member of the herd,

you'll get the vitality of that uh of

that or buffalo or elephant or whatever

the hell they were eating because they

knew the marrow and the and the the

physiology of that of that organism at

that point in its life could provide you

with the strength that that had. Now,

when you eat the strongest members of

the herd because you want to be tough,

you're putting the old and the young at

vulnerable to predators leading to the

extinction. Uh, and this is what a big

paper came out of out of uh, Israel.

They looked at these cavemen, what they

were eating like 500,000 years ago or

whatever they're doing. So, humans

indirectly caused extinction of other

species in part in not in part because

they were eating the toughest guys in

the herd. So, because they felt that if

I eat those guys, I'm gonna be strong

too. And in a way, they're right. But

all of it has to do with the energy

efficiency of your muscles, your brain,

your ability to be resilient, endurance.

I'm telling you, these guys were

chiseled. They they weren't dying from

type 2 diabetes, cancer, right?

Dementia. They were dying from

infections and injuries and child

mortality. Uh we're mostly killing our

paleolithic ancestors. But when you

bring your body back into a low glucose

ketone, you're actually going back like

you were. This is why we developed the

glucose ketone index.

>> What is in that envelope in front of

you?

>> Well, this is um it's a paper that's

under embargo because they they think

it's going to be the world thinks it's

going to be very important and um and it

is.

So, and what it is, this is a

um a way to keep that organel healthy.

So this is a way to manage uh um energy

efficiency in the body.

>> And this hasn't been released yet.

>> It hasn't been released. Okay. It's

coming out. It's a it's going to be a

lead article in the frontiers in

science. And not only that, we the paper

the paper was written

uh for the scientists and then the

journal decided to make a second copy

for they call young minds. So letting

kids that are like 8 to 12 or 14 years

old synthesize it down and and and one

of my colleagues said that's probably

what most people will be reading because

they don't want to know about the

bioenergetics that actually goes on

inside this organel to explain why this

chart means something.

>> And you've been working on this for some

time.

>> Well, I I I built the GKI. So let me

tell you the story. There was a woman uh

an American woman a lawyer Trudy Dupant

who uh developed um a kind of a brain

stem tumor and after I wrote my book

that book there that's my only book

anyway Trudy Trudy wanted to use this

metabolic therapy she stayed alive much

longer over 10 years with this we kept

the she eventually passed away

unfortunately but so I was measuring

because we knew that the tumor cells

needed sugar to grow out of Worberg

showed that and many other people show

that and they can't burn ketones because

because the fatty you need a very

efficient mitochondria to burn ketones

for energy. Our normal cells can burn

ketones for energy and that gives us

tremendous uh uh we can actually breathe

lower oxygen more energy if you have

efficient if you can burn ketones

efficiently in this organel. But if the

organel is damaged, they can't use the

ketones. They can't burn fatty acids or

ketones, which stores lipid drops. It's

one of these big papers here. These

Stephen, you can't believe how people

misinterpret information. They see

droplets of fatty acids in the cytoplan

say, you see the cancer cell needs all

that fatty acid. No, they can't. It's

there to protect them. If they try to

burn it, they blow this up and die. So

there is a storage of fat. They can't

burn fatty acids or ketone bodies. So, I

knew cancer needed glucose, and I knew

cancer couldn't burn fatty acids or

ketones because this organel is is

broken.

So, I'm measuring glucose and ketones

independently in Trudy. She's doing the

finger prick thing, sending me the

information back and saying, "Oh, here's

my glucose. Here's my ketones."

>> Okay, so I have a a ketone glucose

reader in front of me.

>> Right. Right.

>> If I put my blood on this strip, it

tells me my glucose levels. If I put my

blood on this strip, yeah, it tells me

my ketone levels.

>> Right. Right. But if you if you look at

them independently,

>> glucose is very volatile, very variable.

>> And this is why I developed the glucose

ketone ratio because Trudy had a parking

spot that was for handicapped because

she had a cane. Her brain stem gloma was

preventing her from walking as

effectively as normal people. So she

somebody took her parking spot. She was

So she ran upstairs and took

her blood sugar and it was 186 milligram

per deciliter. It was very very high. So

and I know she was on a ke ketoic diet

and and she emails me and says I'm going

to die. My cancer is going to grow fast.

What's going on? She said my blood sugar

is like 186 and you know it's supposed

to be you told me it was supposed to be

60 or you know 50 65 or in that zone.

She says so I said what's your ketone

level? Oh, it's still, you know, like

you just had point4 millmer or I think

it was 0.9 millmer. I said, well, that

didn't change, right? No, just the sugar

changed. So, I said to the students that

were working with Josh Fidenbower, I

said, Josh, this this trying to measure

these two independently is a

You can't this is hard to figure out.

So, what we decided to do in miller

because glucose comes out in milligram

per deciliter whereas ketones come out

in millimmer. So we had to convert

glucose to millimmer and divide it by

the ketone in millimmer and then you get

a number that's not all over the world.

It's very stable. So so we were able to

because of Trudy that one cancer patient

we developed the ratio of of this. Then

later on we realized that this ratio is

a statement of how healthy your

mitochondria actually are. So when you

when you have these low ratio you're in

paleolithic man. you're back in the zone

where we didn't have chronic diseases

because we didn't have damage to the

organel that would cause those diseases.

So, paleolithic men think where are they

getting their pastries? Where where are

they getting their cakes and sweets and

all this other they didn't have it. They

weren't there because of of choice. They

were there because of circumstance. So,

our new and we learned paleolithic man

was always in some sort of a state of

some ketosis because they wouldn't have

food for periods. They were very active

in their exercise. They had they didn't

have chronic diseases, but they had

other kinds of diseases. So, so then um

my my my my student um Derek Lee, myself

and Christo Shinopoulos, we started to

make a ratio chart. Now, these are the

numbers that you get when you divide

your sugar by your ketones.

>> Okay. So, my sugar by my ketones. So, if

I did my glucose measure now on this

little

>> Okay, let's see what your GKI is.

>> Oh, you want me to do it? Okay.

>> Okay. What? You had a glucose. You had a

a ketone was 0.4 millmer.

>> Yeah.

>> Okay. What was your sugar?

>> I haven't.

>> So, we can divide. We can do the divi

division right now and tell you what you

have.

>> You can get these little uh ketone

>> Oh, yeah. It's a keto mojo. And you can

also get them now for for uh

>> Wow, these guys skilled at doing this.

>> I travel with one of these, [laughter]

believe it or not.

>> Yeah.

>> So, I I have one all the time.

>> Wow.

>> 90.

>> 90. Okay. So, you have to you have to

divide. You have to divide. You're not

getting the Doesn't this give you the

push button and give you the GKI right

away? Cuz the new ones have it. So, you

have to divide 90 by 18 and you get a

number.

>> Uh, five.

>> Five. So, divide five by 0.4.

>> 12.5.

>> Okay. So, here you are.

12.5. You're down here in the in the in

the prevention zone.

>> Ah, nice.

>> Okay. So, so you This is where

Paleolithic man mostly lived.

Paleolithic man lived in the yellow

green zones because they didn't have

access to all of the things that would

drive up your blue blood sugar and keep

your key when your blood sugar goes

through the roof your ketones are really

low because insulin is now driving it

up. So So that's good. Um 12, huh?

>> So I I did the I did the carnivore diet

for a week.

>> Uh eating big ribe eyes. You like ribeye

steak?

>> Yes, of course. [laughter]

ribe eyes, bacon and eggs, lamb. I I so

I did it for a week and um I was able to

get down to 10.

>> Okay.

>> Okay. And I could get lower, but I was

loving the ribeye so much I ate a little

too much of it. Right. You have to

[laughter] be have some level of

discipline. Yeah.

>> So, [clears throat] uh so so but people

people this is what we call the zone of

prevention. It's very hard to get cancer

or chronic diseases when you're in these

zones because you're keeping this

organel quite healthy. When you live in

these zones consistently,

>> you you don't have to live consistently

because humans, we we evolved as a

scavenger species. We would engorgorge

ourselves because we knew it wasn't

happening every day.

>> Modern man is live is living in the

feast every single day. And that's why

we're are we have an out all the chronic

diseases. This is the red zone is the

zone of risk for chronic diseases and

cancer. And when you look at the obesity

epidemic, you look at all these things,

these guys are and it's it's like we can

visit the red zone. We don't want to

live in the red zone.

>> So if I was to visit the red zone, it

would look like meeting high

carbohydrate diets, lots of sugar.

>> Yeah. No exercise.

>> No exercise.

>> Yeah. And basically modern man.

>> And also eating five meals a day, like

snacking all the time.

>> Yeah. Oh, then you'd be, you know, we

have uh there's document cases. We have

them up to 500.

>> You can get GKIS of 500.

>> You have people with, you know, blood

sugars about 4 or 500 milligram per

deciliter. I mean, you could do the and

zero ketones. I mean, you you do the you

do the math. It's it's unbelievable.

>> You're basically saying, I want to keep

my my blood glucose levels

>> and you want to you want to have some

level of ketones

>> and high and my ketone levels somewhat

as high as I can.

>> Well, it's you don't want to go because

people then have the physicians

listening. They go, "Oh, he's going to

go with the keto acidosis." People give

me a break. Keto acidosis is like when

you have ketone levels of 15 to 20

millmer. Are you kidding me? What is

yours? 0.4. That's called nutritional

ketosis. That's how we evolved. When you

have type 1 diabetes where you can't

control sugar or or or insulin, you have

no insulin responsive. You're going to

get high levels of sugar and ketones.

This is this is a pathological

condition. Most of type two diabetes,

these are all pathologies based on

damaging oxidative phosphorilation. So

what this chart does is for the first

time and we put it together because we

did all the B in the paper discusses the

bioenergetics. What we're finding in

cancer is that if you can get into the

green zones where your blood sugar is

low and your ketones are elevated, you

hammer the hell out of these tumor cells

because they they they you're taking

away one of their two primary fuels

driving disregulated cell growth. Okay?

And as the and as the and as the ketones

go up, the rest of your cells in the

body are getting super healthy. The

tumor cells can't tap into the value of

a ketone because the organel needed in

the tumor cell to do that is corrupted

structurally and functionally is am I

clear about that?

>> Yes.

>> Okay. So ketones will make you healthy,

the normal cells of your body, but

cannot be used to help the cancer cell

because you need a good structural

functional organel to burn them. So they

become marginalized and if the ketones

go up, they're actually toxic to that to

that cell to some extent. So but they're

still alive. Uh the cancer cells are now

incapacitated.

there. Uh we we showed you get rid of

the abnormal inflammation, you get rid

of the angioen, the abnormal blood

vessels. You're taking an angry tumor

and making it much less angry, much less

inflamed, uh uh more indolent uh kind of

a tumor, but it's still there. It's not

because the other fuel that's keeping

this cancer cell going is the glutamine.

Okay. So now when you have the patient

in this green zone, this is for

management. Now, Stephen, this is

prevention is is never having to deal

with what I'm talking about. If you're

living in the yellow zone, the

probability of getting cancer or chronic

diseases is already reduced. Okay? But

now you have some poor guy out there.

He's living in the red zone his whole

life. He wants to manage the cancer that

he has. He he has to get down in the

green zone and try to stay there as long

as he can. But the cancer will still

grow because it has access to glutamine.

Okay? And glutamine is always here's the

bloodstream. Look at look at you have

this much blood. Cancer needs that. So

you always have a surfitit of glutamine.

So you have to come in now with drugs

and the drugs like repurposed drugs to

target the the glutaminolysis

with this one here this BMC big paper

here.

>> Mhm.

>> Okay. This paper and the new one we have

with the ketogenic for the high

childhood um high-grade gloma for kids.

So once once you get down here, you come

in with drugs that target glutamine.

I've looked at one and that's Mbendazol.

Okay. How did I come to that

realization? People knew that embendazol

had some therapeutic benefit about

cancer, but they don't believe it until

you show the mechanism. That paper shows

the mechanism. It targets glucose and

glutamine. That was this one targets

glucose and glutamine, the two fuels

driving the disregulated growth of the

tumor. Okay. So here's the here's the

mitochondria.

So it's getting the glucose and the

cytoplasm from the sugar uh and making

and it's fermenting that and then also

the the amino acid glutamine comes in.

You have to block the glycolysis and the

gluc these two pathways. You have to

restrict availability of glucose and

glutamine together at the same time.

Yeah.

>> I speak only about things that I have

tested in my lab and published papers on

like this. So you have to real the

cancer field doesn't understand that the

cancer can't grow without glucose and

glutamine and can't switch to fatty

acids or ketone bodies.

>> That's still not going to kill the

cancer though, is it? It's just going to

>> Yeah, we don't ever use the term cure

because some of these tumors, now let me

tell you, we have people like Pablo

Kelly from Devon, England, he had the

glyobblasto

uh he didn't take any radiation or

chemo. He just did metabolic therapy. He

lived for 10 years. He was diagnosed

with an inoperable glyopblast. They

wanted to irdiate and poison him with

the drugs. He said no. He was one of

these naturalistic kind of guys. And um

he he lived for 10 years and the tumor

became operable. He had four debulking

surgeries on an originally described

inoperable cancer cut out four times

because once we put the metabolic

therapy the circle the demarcation of

the tumor. Whoa. A neurosurgeon says I

think I can get this out. But he never

never got rid he lived with it for 10

years. Had a couple of kids. He died

from a cerebral hemorrhage on the last

debulking surgery. He never died from

the tumor.

>> But you're saying you're saying that the

two work together in in tandem. You're

saying that the chemotherapy works in

>> the Now that's where that's another

thing. So what we do u this is very

interesting. So if you put the patient

in nutritional ketosis, the the

ketogenic

state of nutritional ketosis facilitates

the delivery of drugs to the tumor cell.

It actually makes you can use lower

doses of drugs and you and and and you

get bigger effect. The therapeutic

benefit increases with lower dosing.

>> So you want to be in ketosis when you do

these chemotherapy, radiation therapy.

>> Yeah. And then you use much lower doses.

This is what we're doing in a stimul

clinic. We're taking pancreatic cancers.

These guys live in four and five years.

What are we doing? And advanced breast

cancer and all these terminal cancers.

We put them into some level of ketosis

and then you come in with the standard

drugs, cis platin, carboplatin, whatever

you want to do, but you cut the dosages

down big time and then they have tremend

the the uh and this is what the title of

the paper is ketogenic diet uh as a

metabolic vehicle

uh for enhancing therapeutic efficacy.

The current body of research suggests

that being in a state of ketosis can act

as a helper therapy, enhancing the

cancer killing effects of chemotherapy

while simultaneously protecting healthy

cells.

>> Yeah. Yeah. Right. Right.

>> Progressive oncologists are currently

using ketogenic diets alongside standard

chemo to maximize its efficacy.

>> That's right. That's what we're doing in

Istanbul

and and and also in in in Greece. We're

doing we're doing those same things. So

you you can use this

>> when you enter a fasted or ketogenic

state. Your healthy cells essentially go

into bunker mode. They slow their

division, conserve energy, and build up

their defenses. Cancer cells, however,

do not have this evolutionary off

switch. They continue trying to rapidly

divide. When the toxic chemotherapy

hits, your shielded healthy cells

survive it much better. While the

exposed rapidly dividing cancer cells

take the full hit.

>> Yeah.

>> Oh, okay. Interesting.

>> Yeah. In other words, you make with the

tools you have work better. The problem

in the field of cancer today is they're

not using the tools in the correct way.

Now, let me give you another example. If

you take imunotherapies, you hear about

these things, chimeic acid, G receptor,

PDL, PD1, PDL1 inhibitors, they're

called precision medicines, right? So

look, they're designed

to attack a a molecule on the surface or

stop that cell from uh being resistant.

>> Mhm.

>> If you would try to attack and what they

do often times, they come at after

you've failed chemo and radiation, they

then come at you with an imunotherapy.

The metabolic pressure shrinks down your

tumor, makes it very indolent,

>> non-aggressive, and the rest of your

body is healthy. You're not going bald.

You're not bleeding gums. Your

microbiome isn't blown to hell. So, and

then you can come in with lowdose chemo

imunotherapy because what'sever left in

that remaining residual mass, they may

all have something in common for having

survived all this, right? So now you can

come in with a precision medicine and

possibly resolution. I thought this was

fascinating. It says chemotherapy

creates massive oxidative stress, i.e.

damage inside the tumor. To repair the

damage and survive, the cancer cell

requires massive amounts of glucose. So,

if the patient is in ketosis, the

tumor's glucose supply is essentially

cut off. It can't the cancer cell can't

repair the DNA damage caused by your

chemo, leading to faster tumor death.

Um, yeah, interesting.

>> Well, don't forget also, listen to this,

and there's another thing people go in.

What protects the tumor cell from chemo

and radiation is the waste products of

fermentation. The lactic acid and the

suxinic acid that are dumped out of this

raging beast prevent these other

therapies from working. So if you want

your therapy to work, you got to target

those two fuels together at the same

time. And when you do that now this cell

the shield is off. These things are

super vulnerable to even low doses of

chemo and radiation. And the

imunotherapies, look at if you have an

imunotherapy, you try to attack the

beast when it's at its strongest. H

you're not going to win. And this is

what happens. You get only partial

response. They in the field of cancer

today, they think living an extra six

months is a major breakthrough. We're

talking about living an extra five and

six years. This is what's really

important. I just um I was reading some

research to figure out if oncologists so

cancer doctors are currently

recommending the ketogenic diet and it

says the vast majority of mainstream

oncologists do not recommend the

ketogenic diet to the to their newly

diagnosed patients. Um in fact if a

patient brings it up many doctors will

actively advise against it and the

reasons for that number one is the fear

of cacettia. Cexia. Yeah.

>> Cexia. Cancer. Cexia is a severe wasting

syndrome where patients rapidly lose

muscle and fat. It is a massive problem

and a leading cause of mortality in

cancer patients. Because the ketogenic

diet suppresses appetite and often leads

to weight loss. Encologists are

terrified that a strict keto diet will

accelerate cexia and weaken the patient.

>> Well, that's because they they have not

heard what I just said with respect to

the biology and biochemistry. Okay.

Cexia there's two ways you can lose in

cancer patients. CEXIA is the ability of

the tumor cell to mobilize energy out of

the muscles. It's taking the glutamine

out of your muscles and feeding. This is

one of the two fuels that's driving the

beast is glutamine. Where are they

getting the glutamine from? They're

getting the glutamine not only from the

bloodstream, but they dissolve your

muscles as a uh as part of that part of

that process. So, when you put a patient

in nutritional ketosis,

the weight loss is therapeutic weight

loss. CEXIA is pathological weight loss.

Now, the only way you can lose weight is

you take a high dose of chemotherapy.

I travel all the time. So, I made a rule

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Okay, so that's 24 black t-shirts.

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Stick it on there. I can now take more

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frequently and you want to get one of

these so you can save more space and be

away for longer, go to extra.com and use

code DOAC for 10% off our collection.

And I think some of the background

context here is that mainstream oncology

operates on the um sort of sematic

mutation therapy, which is the belief

that cancer is fundamentally a genetic

disease driven by DNA mutations. And

because their training focuses on

genetics, their treatments are designed

to target DNA and cell division like

heradiation targeted genetic therapies

rather than manipulating um cellular

metabolism. And lastly, as mentioned, I

think we talked about this earlier,

mainstream medicine requires massive

multic-enter double blind phase 3

clinical trials before a protocol

becomes the standard of care. So dietary

interventions rarely get the level of

funding. So on ancologists lack the

institutional green light to prescribe

them to patients and they tend to say to

them eat what you can.

>> I I don't blame them. They're good. Many

of them are good people. The problem is

the system doesn't train them to

understand the biology and biochemistry

of the disease they're treating. Uh some

of them become very resistant to this.

They say get angry because if I why

didn't I why wasn't I told this? Well,

first of all, they're not reading these

papers. Uh you ask them about it. They I

never read it. Well, how are you going

to know anything if you don't read the

literature? Um, listen to this. The

National Cancer Institute, the NCI, on

their website, on their website says

cancer is a genetic disease caused by

what you just said. Okay, they I well I

said why don't they put the articles in

there showing all the tumors they can't

find any mutations. The somatic mutation

theory says that cancer is caused by

random genetic mutations. So now new

sequencing of normal people like you and

me are finding mutations in all these

driver genes in cells in our body that

aren't in disregulated cell growth. So

we're calling them wild type cancers.

What do you mean a wild type cancer?

>> You lost me.

>> Okay. The nucleus of a tumor cell, a

raging tumor cell.

>> What's causing him that cell to grow? Is

it the mitochondria and the cytoplasm or

is it the mutations in the nucleus?

Okay. So according to the sematic

mutation theory, it's the mutations in

the nucleus that are causing the

disregulated cell growth. You take that

nucleus and put it into into a

enucleated normal cell.

>> Yeah. And there's no cancer.

>> No can there's no disregulation.

>> There must be something else.

>> Then you take the nucleus of the normal

cell and put it into the cytoplasm of a

tumor cell and you get disregulated cell

growth.

>> So it must be something other than the

nucleus.

>> Yes. The mitochondria.

>> Interesting. And it says

>> so with mitochondria controlling our

destiny and and and the the field of

cancer has yet to understand it, accept

it, and then say, "Well, we can't do any

of this until we double the line

crossover." That's just what do you

mean? The science is telling us this.

That's your way of protecting a broken

system.

>> Are you pissed off about this? Cuz you

do seem pissed off about this.

>> Well, who wouldn't be,

Stephen?

There's 1,700

people a day in this country dying from

cancer. I don't know the English.

Listen, that that comes out to 70 an

hour. And it gets worse every single

year. And the last time I was on the

show, you guys use some old data. Look

it up today. It's 2026. American Cancer

Society says this year in 2026 we will

have 626,000

souls leave the planet from cancer.

Okay, this 2026 and every year it gets

worse. So when you hear all the

breakthroughs, we have we have

television ads in Boston for the cancer.

Breakthrough after breakthrough after

breakthrough. All these different they

come on and and and and all we do is get

more dead cancer patients. Raise money

for cancer. Where's the where's the

accountability for all the money you're

raising? When are the work when is the

people going to wake up? You don't make

someone healthy by irdiating and

poisoning them. You've got to understand

the biology and the biochemistry of the

disease. I have the concepts and the

proofs, but the physician who works with

the patient on a clinic basis, they're

the ones that must apply this to the

clinic. So, there's two different things

here. There's the hard science that's

the that's the bedrock for this and then

there's the clinical person who has the

practice that practice does that.

Together, you get great success or

better I say success better than

anything that's out there today. The

American Cancer Society recently

released its latest projections for 25

and 26, and the data paints a

fascinating dual-sided picture. More

people are getting diagnosed with

cancer. Um, new cases. The ACS projects

over 2.11 million new cancer diagnoses

in 2026. This translates roughly to

5,800 new cases every single day.

>> Approximately 626,000 Americans are

expected to die from cancer in 2026.

>> Right. about 1,700 deaths per day. Lung

cancer remains the leading cause of

cancer death projected to cause more