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The Male Fertility Doctor: Delaying Having Kids Is Impacting Your Future Kids! Dr Michael Eisenberg

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The Male Fertility Doctor: Delaying Having Kids Is Impacting Your Future Kids! Dr Michael Eisenberg

Transcript

2717 segments

0:00

men need to understand the average age

0:02

of the father has gone up about three

0:03

and a half years and with that the

0:05

chance of problems with the child also

0:07

can increase then that pregnancy becomes

0:09

a lot riskier and this is why Dr Michael

0:12

Eisenberg is an expert in male sexual

0:15

function and fertility who's helping us

0:17

to learn the truth about optimal Sexual

0:19

Health if you just look at all the data

0:21

sperm counts are declining but low sperm

0:23

counts and low testosterone could have

0:25

devastating effects for example men with

0:27

lower semen quality have higher risk of

0:29

death wow and there's a lot of really

0:31

interesting questions that need to be

0:33

answered okay let's get into that is

0:34

there any evidence that the chemicals in

0:36

our environment are impacting our sperm

0:38

count now testosterone levels yes it's a

0:40

chemical that's in a lot of creams and

0:42

lotions that we use and then there's a

0:43

chemical that's used in the manufacturer

0:45

of plastic and that could have pretty

0:46

devastating effects and so don't drink

0:48

out of plastic water bottles what about

0:50

paros couldn't figure out if low

0:52

testosterone or high testosterone causes

0:54

a receding hairline most men are not

0:56

going to in like this but it turns out

0:57

that if I'm sat down all day is that

1:00

going to have an impact on my sperm C

1:01

there are studies that do support that I

1:03

would say take breaks stand up to try

1:04

and air out the area what can I do to

1:06

give myself the best possible chance of

1:08

increasing my fertility so there's a lot

1:10

that we can do and usually we start with

1:13

and then erectile dysfunction hundreds

1:15

of millions of men all over the world

1:16

have trouble with directions but as long

1:18

as you have a penis we can always make

1:19

it hard for example we can teach men to

1:21

give

1:22

themselves ooh I just got shiver down my

1:25

body but it probably works 80 to 90% of

1:27

the

1:28

time congratul ulations Dio gang we've

1:31

made some progress 63% of you that

1:33

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1:57

[Music]

2:02

Dr Michael

2:03

Eisenberg why do you do what you do and

2:06

what you do it's a pleasure to be here

2:09

certainly an honor um I kind of see

2:11

myself as a researcher and advocate for

2:13

Men's Health men's reproductive Health

2:15

sexual health and so you know I think

2:17

when I see patients in clinic that's

2:19

what I'm trying to do to try and

2:20

understand where they're coming from any

2:22

issues they have and find out ways that

2:24

we can you know work and improve them

2:25

together and certainly from my research

2:27

perspective I always want to you know

2:29

try and Define what the issues are um

2:32

and just improve our treatments that we

2:34

have for men I am the director of male

2:38

reproductive and Sexual Health at

2:39

Stanford or Men's Health uh in the

2:41

Department of Urology um I have a joint

2:43

appointment in the department of obstetr

2:45

and Gynecology because fertility is a

2:46

team sport and so I also help you know

2:48

couples and I refer women to the female

2:51

side and just like I you know get lots

2:53

of referrals from them you know when

2:55

we're kind of worried about the male

2:56

partner when you say sort of

2:58

reproductive Health what what are all

3:00

the sort of things that fall within that

3:02

bucket or underneath that

3:04

umbrella so I think you know

3:06

reproductive Health really I mean I

3:08

guess as it sort of name implies would

3:10

be you know trying to have a baby um but

3:12

I think it's so much more than that

3:13

because I think what we're really

3:14

learning is that you know fertility is

3:16

kind of a window into future health

3:18

probably about 10% of the male genome is

3:20

devoted to reproduction um and given

3:23

there's only about 25,000 genes in the

3:24

body you know it makes sense that some

3:26

genes that are operating in reproduction

3:28

also operate in another organ system

3:30

there was a study done where they took

3:31

biopsies of men that had troubl making

3:33

sperm and tried to sort of replicate

3:35

these cells and they found that these

3:37

cells had very high rates of mutations

3:38

in their DNA so you can imagine you know

3:41

sort of for checks and balances when

3:43

we're making sperm it makes sense if you

3:44

can't sort of faithfully replicate your

3:47

DNA you know there's probably not

3:49

there's probably going to be some blocks

3:50

where you can't make a sperm right if

3:51

there's going to be mutations but also

3:53

these men may be set up for other

3:54

problems right like cancers or something

3:56

like that if you know the body can't you

3:58

know effectively replicate cells or DNA

4:00

there could also be sort of hormonal

4:02

links and that's another thing that we

4:03

commonly look at when we're evaluating

4:05

men uh with infertility um infertile Men

4:08

actually have lower testosterone levels

4:10

than fertile men so you know there's

4:13

also been studies show that men with

4:14

lower testosterone levels have you know

4:16

sort of lower survival so it may be that

4:19

you know kind of hormonal links between

4:22

fertility May kind of put men on a

4:23

different you know trajectory you know

4:25

another I think very sort of important

4:27

aspect of reproduction you there's other

4:30

kind of what I call sort of social

4:31

factors that are sort of at play um you

4:34

know things that kind of necessarily go

4:35

with reproduction so like having a

4:37

partner um and having kids hopefully and

4:41

it turns out that those factors actually

4:42

are very important for Health and

4:44

Longevity so um like having a partner

4:48

actually increases survival so if you

4:51

like compare sort of if you have like a

4:53

you know a man with a partner and a

4:55

child if you then take away the partner

4:58

the chance of that man dying goes up 60

5:00

% and then if you take away just a child

5:03

the chance of him dying goes up

5:06

60% but it turns out if there both of

5:08

those things are absent that man has a

5:10

three-fold higher risk of death than

5:11

somebody with a partner and a

5:14

child so there's really kind of this

5:16

sort of important aspect I think to

5:18

health and reproduction I think that men

5:20

kind of need to understand and then

5:22

obviously there's also just a lot of you

5:24

know kind of um intrinsic things that we

5:26

do like lifestyle Behavior obesity

5:28

smoking those are all very important um

5:31

for health as well um so I think you

5:33

know when I see these men for

5:34

reproduction I really try and broaden it

5:36

a little bit to overall health because I

5:38

think there's certainly data that you

5:40

know as we improve a man's health we'll

5:41

improve their reproduction um and

5:44

hopefully give them a baby but also you

5:45

know improve their overall you know

5:48

survival Health everything so how many

5:51

patients have you seen in your career if

5:54

you had to Hazard a guess roughly oh I

5:57

mean I think it would probably be

5:59

mean tens of thousands I would guess

6:01

maybe 20 30,000 and how many years have

6:05

you been working on this subject of sort

6:06

of male Health fertility uh reproductive

6:09

Health all these kind of about probably

6:12

10 to 15 years it feels like the world

6:15

has kind of turned towards your work

6:17

more so in the last couple of years than

6:18

ever before it feels like you you just

6:21

so happen to be doing research and

6:24

educating people on a space that quite

6:26

suddenly relatively suddenly has become

6:30

really important to people and I was

6:32

even looking at some of the data around

6:33

sort of testosterone replacement

6:36

therapies and how that's just absolutely

6:38

skyrocketed in recent times and also the

6:40

conversation around fertility I was

6:42

looking at the data around fertility how

6:43

many people are searching out for

6:45

information on it and it's skyrocketed

6:47

over the last what five years and even

6:49

in my circle of friends we weren't

6:51

talking about fertility or testosterone

6:54

or sperm count even two years ago

6:57

whereas this year and then last sort of

7:00

12 months it's been a frequent topic of

7:02

conversation why is this and is my

7:04

assessment there accurate and can that

7:06

be supported with what you're seeing I

7:09

mean I think so I you know obviously I

7:11

guess I would say I'm biased and that I

7:12

think this is um you know very

7:14

interesting and I think you know there

7:16

is a lot of momentum towards us you know

7:17

there have been a lot of landmark

7:18

studies suggesting like you say declines

7:21

in testosterone over time uh declines in

7:23

sperm count over time and we can

7:25

certainly talk about that um a little

7:27

bit more and I think with that you know

7:30

um there's been really an explosion in

7:32

assisted reproductive Technologies you

7:33

know I'm familiar you know in the United

7:35

States how that's happening you know a

7:38

few years ago it was you know maybe

7:41

about half percent of all bursts in the

7:43

i in the US were conceived with IVF now

7:45

it's about 2% and only increasing you

7:47

know it used to be that insurance never

7:49

covered it now Insurance commonly covers

7:51

it and so with that there's just really

7:52

been explosion in the offerings the

7:54

number of cycles that are done you know

7:56

and in my particular area in Northern

7:58

California you know it seems like every

8:00

year a new IVF Clinic um is opening up

8:03

and you're always worried and wondering

8:05

how could there be enough business to

8:06

support it but instantly you know all

8:08

the patients you know all the slots are

8:10

filled they're booked out for six months

8:11

and I think there's just tremendous

8:13

amount of demand and I think that you

8:15

know I think to your point you know the

8:17

question really is why you know is is

8:19

fertility declining are more couples

8:22

becoming riing on IVF um and I think you

8:25

know again our sperm counts declining I

8:27

think all those things are probably kind

8:28

of going together

8:30

um that's leading to this and I think

8:32

it's you know it's something that we're

8:33

doing to ourselves potentially there's

8:34

some environmental exposure I think all

8:36

these things are you know really

8:37

interesting questions that that need to

8:39

be answered so let's start with why then

8:41

if we stay zoomed out a little bit on

8:43

some of the social factors that might be

8:44

leading to um infertility issues but

8:48

also just correlated issues like things

8:50

like testosterone and all of these

8:52

things what are some of the broader

8:54

social factors that are causing IVF

8:56

clinics to become so in demand now yeah

8:59

I mean I think one of the big ones would

9:01

just be uh Rising parental age um you

9:05

know

9:06

uh there's been sort of less data I

9:09

think on male age over time at least

9:11

here in the United States but um you

9:13

know a few years ago there was a study

9:14

done where it showed that over the last

9:16

maybe 30 40 years the average age of the

9:19

father has gone up about three and a

9:21

half years um it used to be like in the

9:23

70s you know the an older father and

9:27

that would be considered over 40 was

9:28

maybe about 4 % of bursts now it's

9:31

probably 9 10% of bursts so I think

9:33

there's just more delay and with that um

9:36

you know infertility gets higher there's

9:38

usually a close correlation between you

9:40

know a mother's age and a father's age

9:42

and so you know I think a lot of people

9:44

are sort of familiar as women get older

9:46

um you know fertility goes down probably

9:48

at a steeper rate but for men the same

9:49

thing happens you know sperm counts get

9:51

a little lower testosterone gets a

9:53

little lower takes a little longer to

9:55

conceive you know the chance of problems

9:57

with the CH the child also can increase

9:59

I mean the oldest father ever is 96 so

10:02

the biologic potential does persist um

10:05

but it certainly gets a little bit more

10:06

difficult in that pregnancy becomes a

10:08

lot riskier what is the rate of decline

10:10

in men and women um in terms of

10:12

fertility so I think you know if your

10:15

guest you're looking from an

10:15

evolutionary standpoint you know Peak

10:17

fertility probably be late teens early

10:19

20s something like that and so for women

10:21

you know they're born with a set number

10:23

of eggs and so as soon as you know

10:25

Cycles start they continue to lose them

10:27

over time and so usually we think about

10:30

you know over 30 35 40 you know those

10:32

are pretty big points where fertility

10:34

gets a little bit more challenging for

10:36

men you know we the the sperm counts do

10:40

decline you know why this sort of cut

10:41

off where we say older father is 40 is

10:44

sort of a constellation of sort of

10:45

different risks you know the sperm

10:47

counts get a little bit lower but the

10:48

other thing that happens is every year

10:51

um you know we're born with sort of

10:52

sperm precursors or sperm stem cells in

10:55

our body and they are constantly

10:57

replicated every year and every time

10:59

that happens there's some chance of a

11:01

mutation occurring so it turns out that

11:03

you know every year we probably

11:04

accumulate sort of two mutations in our

11:06

DNA and so over time you know that

11:09

becomes a little riskier so for like a

11:11

40-year-old is going to have 20 more

11:13

mutations than a 30-year-old for example

11:15

so we have you know billions of base

11:17

pairs of DNA in our body so the chance

11:19

of you know 20 you know mutations making

11:21

a difference is probably pretty low um

11:24

but you know that's at an individual

11:25

level at a population level that's

11:27

something that you may start to see and

11:29

so for men I think it is just sort of a

11:31

slow steady decline you know again

11:33

probably in the 30s 40s do you have the

11:35

data on the oldest ever mother are you

11:38

the oldest ever woman to conceive a

11:40

child so with uh using like a donor egg

11:44

I think it's 60s or even even in the 70s

11:47

I think it's been described before but I

11:49

think with her own egg I think it's late

11:52

50s early 60s are you concerned about

11:55

this as a macro Trend because if we play

11:56

this forward it would lead us to a

11:59

assume that fertility is going to be an

12:01

increasing problem for

12:03

society yeah I mean I think very much so

12:05

right it's existential I mean you know

12:07

as a disclaimer obviously I'm in the

12:09

fertility business so um you know I do

12:12

certainly care about this trend and want

12:13

to make sure that we reverse it it's a

12:16

risk factor that we know about but I

12:17

think you know the the solution is not

12:19

obvious right because asking couples to

12:22

delay careers education all that is very

12:25

challenging you know I think some

12:27

countries have try to come up with you

12:29

know ways to support you know Parenthood

12:32

you know through leave or you know other

12:35

kind of programs like that child care

12:36

also becomes uh you know very important

12:39

um but even with those I think that um

12:42

there's just sort of a perception it's

12:43

just it's not as easy as you'd think and

12:45

it turns out actually that you know the

12:47

return on investment for some of these

12:49

things you know having a child is so

12:51

kind of important for the health of a

12:53

society right there's some there's this

12:55

concept called replacement rate that's

12:56

the number of children that need to be

12:58

born to a reprodu age women to maintain

13:01

a population's level sort of this is

13:03

kind of ignoring immigration so it turns

13:05

out you need about 2.1 children per

13:08

reproductive age women for a population

13:10

level to stay the same so if you in some

13:13

societies it's lower like in the US it's

13:16

a little lower than that and some um

13:18

like Asian countries like Korea JP Japan

13:21

it's lower than that and that's really

13:23

existential because if you know if your

13:24

working population starts to decline um

13:28

you know tax Spas everything you know

13:30

will really collapse and so from an

13:32

economic standpoint it makes sense if

13:34

these are couples that want to have kids

13:36

and they you know these are wanted

13:38

children you know to try and invest in

13:41

you know allowing them to do that really

13:43

makes sense because you

13:44

know it'll it'll kind of pay it back it

13:47

is at a societal level I read about in

13:50

Hungary that if you have four or more

13:52

babies then you'll pay no income tax for

13:54

the rest of your life according to the

13:56

Prime Minister it's an article that I'd

13:57

seen and I think this is speaks to a

13:59

broader trend of how there's going to be

14:03

a topown approach towards getting us to

14:05

be get back to having babies to stop the

14:08

population collapse and decline that you

14:10

talked about um hungary's prime minister

14:12

has announced a raft of measures aimed

14:14

at boosting the country's declining

14:15

birth rate and reducing immigration and

14:17

one of them is that essentially you'll

14:19

get be given a check and you only have

14:21

to pay that check back if you don't have

14:23

four kids so for every kid you have 25%

14:27

of the money that you're given is

14:28

discounted and once you get to full kids

14:30

you never have to pay income tax again

14:32

which I thought was a

14:33

really interesting idea but it's a sign

14:35

of things to come yeah yeah I mean it's

14:38

fascinating right I mean I think that

14:39

these you know the economic ministers

14:41

Prime Ministers are really thinking

14:42

about things I'm sure they've looked at

14:44

the numbers right and realize that um

14:48

you Society really relies on you know

14:50

maintaining numbers and when you know

14:52

when the population starts to slip could

14:55

be a problem I mean I think that's it's

14:56

a very clever solution

14:59

sperm

15:01

quality sperm quality I read is

15:04

declining yeah so that's a very it's

15:06

interesting because that's such a

15:07

controversial statement uh you know I

15:09

think there is a tremendous amount of

15:11

data that supports that a number of

15:13

years ago I was actually involved in a

15:14

study looking at data from a sperm bank

15:16

here in the United States um it was a

15:19

sperm bank that was in uh the

15:21

northeastern us at a few locations and

15:24

it wasn't a lot of data it was just sort

15:25

of a few years of data um about like a

15:28

little over maybe 10 15 years but what

15:31

what we found is that actually if you

15:32

looked at men that were coming in to try

15:34

and be donors because you know these

15:35

Banks they're very selective so you have

15:37

to have you know excellent sperm that

15:39

freezes well that thaws well really high

15:42

numbers and you know they also look at

15:43

your pedigree a little make sure there

15:45

aren't conditions to run your family

15:46

they like you to be fit you know these

15:48

are kind of things that are thought to

15:50

you know sort of make make a better

15:52

donor um and when we looked at sort of

15:54

the candidates that came in over this

15:55

you know really short period of time

15:57

probably 10 15 years there was declines

15:59

in you know sperm counts um you know the

16:03

movement shape all these sort of

16:04

parameters that we look at when we're

16:05

talking about a seman analysis and what

16:07

was interesting is that you know when

16:08

people have talked about declines in

16:10

sperm count people have sort of

16:11

attributed to different things for

16:12

example people have talked about the

16:14

Obesity epidemic right and that maybe

16:16

we're more sedentary now than we used to

16:18

be or you know environmental exposures

16:20

or another thing there's more chemicals

16:22

now than it used to be or cell phone

16:24

prevalence and things like that but you

16:26

know over this short period of time

16:27

where we did have you know a lot of

16:29

information on these men they filled out

16:30

surveys um you know they filled out kind

16:32

of Rich family histories they filled out

16:35

information about whether they drank a

16:36

lot smoked a lot things like that

16:38

there's really no differences in these

16:40

men you know from the beginning of the

16:41

study to the end the only difference was

16:43

that their sperm counts were lower so it

16:45

was really you know kind of surprising

16:47

um very interesting and so you know

16:49

other investigators have used studies

16:51

like that kind of pulled them all

16:52

together using kind of advanced

16:54

statistical techniques and found this

16:56

decline over time um you know over the

16:59

last maybe 20 30 40 50 years um so there

17:04

is a preponderance of data that supports

17:06

that so the counterargument that others

17:08

have made is that you know over that

17:10

same period of time some of our

17:11

techniques have changed right we're

17:13

better at counting sperm now than we

17:14

used to be you know some of the

17:16

different um you know tools that we use

17:18

to measure sperm count some of the

17:20

analyzers are better now than they used

17:22

to be so we're a little bit more precise

17:23

than we used to be the other um you know

17:26

thing that these Studies have done is

17:27

when they pull together data they assume

17:29

that you know everybody's the same like

17:31

right if we were both in the study they

17:32

would assume that I'm like you you're

17:33

like me but it turns out that there's a

17:35

lot of variation based on like region so

17:38

there was a study in the United States

17:40

where they looked at fathers so men that

17:41

had kids at different regions of the

17:43

country you know like had some in

17:45

California New York some in the Midwest

17:47

and even though these were all fathers

17:49

similar ages the sperm quality was much

17:51

different turned out it was really high

17:53

and in New York I think California was

17:55

next and the Midwest was a lot lower um

17:58

so so you know again why you think that

18:00

right New York would be kind of hustle

18:02

bustle Metropolis maybe they would have

18:04

some poor risk factors but turns out

18:06

they had the best sperm and so why that

18:08

is is you know wasn't certain but it

18:10

just shows us that there's a lot of

18:11

variation in seon quality from

18:13

individuals so when you put things

18:15

together sometimes it can be difficult

18:17

to you know to identify Trends so

18:18

ideally what we do is you know I and my

18:21

neighbor would give sperm maybe every

18:23

year every 5 years 10 years over time

18:25

and you'd see what changed um and those

18:28

studies aren't ail so that's sort of the

18:29

criticism of these studies but again if

18:32

if you just look at all the data if you

18:34

compare studies from the you 70s ' 80s

18:36

90s to today sperm counts are lower what

18:39

is the current best guess as to why

18:41

sperm counts are lower yeah I think

18:42

that's the million-dollar question

18:44

because I you know we've talked about

18:45

this is sort of an existential

18:47

existential threat right we need a you

18:49

know I think any species has sort of

18:52

three main functions right eat survive

18:53

reproduce you eat to survive you survive

18:55

to reproduce spread your DNA and so if

18:57

you can't do that it's definitely going

18:58

to be an issue so you know I think that

19:01

we've talked about you know maybe

19:02

obesity I think we're certainly

19:03

different now than we used to be you in

19:05

terms of walking around you know um

19:08

sedentary Behavior people have you know

19:10

hypothesized different chemicals in the

19:12

environment are kind of leeching into

19:13

our food supply our water supply is

19:15

there any evidence for that that the

19:17

chemicals in our environment are

19:18

impacting our sperm count and our

19:20

testosterone levels and things like that

19:22

yeah there are there are studies uh that

19:24

do support that um you know there are

19:26

certainly like pre-clinical studies you

19:28

know where you can actually you know

19:30

dose like rats um and mice these there's

19:34

also human studies where you can you

19:35

know compare sperm quality to you know

19:37

different sort of chemical traces in the

19:39

blood and see these correlations as well

19:42

and then there's um a study called enh

19:44

Hanes which is a a study by our Centers

19:47

for Disease Control where every year men

19:50

and women are sort of surveyed or they

19:52

collect data on Obesity blood pressure

19:54

things like that um and they do collect

19:56

data on sort of chemical exposures for

19:58

these you know select group of

19:59

individuals that kind of represent the

20:01

whole population this has been done for

20:02

the last you know many many decades and

20:05

so when we talk about obesity kind of

20:08

rising in prevalence in the United

20:09

States it's been it's based on that data

20:11

this is kind of a rigorously sort of

20:13

researched you know group of individuals

20:15

it's selected every year and so those

20:16

same studies collect data on

20:18

testosterone or estrogen for women and

20:21

they collect it on these different

20:22

environmental chemicals and do see these

20:24

correlations I would say that not every

20:26

study supports this but there are

20:27

certainly a good number that do show

20:29

that um there is this correlation that

20:31

if you have higher exposure to some of

20:33

these chemicals uh there's higher risk

20:35

of lower hormone levels what are those

20:38

chemicals and where do we find them CU I

20:40

I I spoke to someone who was a urologist

20:42

recently um I think from NYU and they

20:45

were telling me that things like the

20:49

microplastics and I'm not particularly

20:50

aware of what a microplastic is to be

20:52

honest but things like microplastics in

20:54

our environment are some of the

20:55

chemicals that are causing sperm quality

20:57

to reduce mhm is there evidence to

21:00

support that there's a lot of different

21:02

chemicals to be sort of concerned about

21:03

or think about I think you know

21:04

microplastics are one phalates what is

21:07

aite aite is it's a chemical that's in a

21:10

lot of like um you know different uh

21:13

like creams and lotions that we use um

21:16

and so those also have been shown to

21:18

affect Androgen you know and kind of

21:20

endocrine function inside the body uh

21:23

bisphenol a is a you know a common

21:26

chemical that's used in the manufacturer

21:27

of plastic and that's also been found to

21:29

have these endocrine disrupting

21:31

properties um so that's also been

21:32

correlated with Sean quality endocrine

21:35

disrupting endocrine disrupting what

21:37

does that mean so you know if you look

21:39

at sort of Pathways for men and women

21:42

there's you know hormones right I'm

21:43

making testosterone and that acts on my

21:46

body as I was a child to help make me a

21:47

man now it kind of helps you know keep

21:50

me a man you know with grow a beard all

21:53

those sorts of things giving me my U my

21:55

deeper voice um and so there's some of

21:57

these chemicals that kind of mimic some

21:58

of that action or block some of that

22:00

action and so if that happens um it can

22:03

affect you know normal development of

22:05

you know boys or girls you know maybe

22:08

you know again affect sort of semen

22:09

quality if we think about sort of the

22:11

origins of changes in semen quality some

22:13

of it may be when we're adults but some

22:15

of it also could be during development

22:16

you know either when we're developing

22:18

inside of our mothers or you know during

22:21

puberty if something kind of affects the

22:23

normal timing of that it could be you

22:25

know again could have pretty devastating

22:26

effects and so one theory for that is

22:28

some of these chemicals that affect

22:30

these sort of biologic Pathways these

22:32

endocrine Pathways involved in that from

22:35

the research you've seen on sort of

22:37

these chemicals is there any changes

22:39

that you've made in your own life at all

22:41

anything that you it's kind of made you

22:42

think differently about the choices you

22:44

make in your own life with your kids

22:45

because you got three kids so you have

22:47

an opportunity to kind of influence them

22:49

at a at a earlier stage than most of us

22:51

can influence ourselves but yeah so one

22:54

thing that we do um is I've thrown away

22:56

all plastic water bottles I I'd say I

22:58

still use it because I find them very

23:00

convenient um and I'm done with

23:02

reproduction but um but certainly for

23:04

the kids um I make sure they don't drink

23:07

out of plastic water bottle so we have

23:08

either glass or um or metal I do think

23:12

there is data that that's um you know a

23:13

very you know large exposure that kids

23:16

get and I think it's you know fairly

23:18

easy now to remove that what does the

23:20

data say about plastic bottles you know

23:23

if you look at um you know exposures

23:25

from that you know they have they just

23:27

leech a tremendous amount you know with

23:28

wash with water it kind of sits there

23:30

all day so I think it's a it's a very

23:34

you know again most plastic water

23:36

bottles want the you know plastic bottle

23:38

industry to come after us but um that's

23:41

a common way for you know individuals to

23:44

get exposed to it so I think if again if

23:46

we're saying that's one of the main

23:48

touch points for Plastics um is is

23:50

usually through our kind of food and

23:51

water supply then yeah I think it's easy

23:54

to to get rid of it if you

23:55

can is there anything else I I I've read

23:58

recently that heat has a a role in our

24:01

sort of sperm quality so if we're don't

24:04

know if we're going into saers or

24:05

something or if we're spending a lot of

24:06

time I don't know sunbathing then

24:09

there's science that suggests that will

24:10

lower our sperm count yeah so that is

24:13

right so I mean I think that you know gu

24:15

you can kind of look at this sort of in

24:17

a bigger sort of global warming kind of

24:19

context and people have you know

24:21

theorized that maybe that could also

24:23

play a role because you know the

24:24

testicles are outside the body because

24:26

they need to be a few degrees cooler for

24:27

sperm production to occur so anything

24:29

that warms them up can definitely be a

24:31

problem um so when I talk to patients in

24:34

clinic for example we do talk about Saun

24:35

use hot tub use some men bathe every day

24:39

like in a bath um and those all can

24:41

impact sperm production there there have

24:43

been studies to show that men that you

24:44

know use you know saunas on a regular

24:46

basis they have lower sperm counts and

24:48

then when you withdraw that exposure um

24:51

sperm counts will go back to normal one

24:53

you know sort of interesting application

24:55

of this was to try and use this data or

24:57

use that knowledge to come up with a

24:59

contraceptive so there was this weird

25:01

sort of like truss kind of belt that

25:03

actually pushed the testicles up into

25:05

the groin um which actually turned out

25:08

did reduce sperm counts uh to zero I

25:10

think and again the the few men that

25:12

that volunteered to do that um but you

25:15

can imagine I think most men are not

25:17

going to be too excited about that um

25:19

because it's probably pretty

25:20

uncomfortable uh the other way that I've

25:22

seen it is I've had patients that have

25:24

gotten sick certainly around covid that

25:26

happened not infrequently men would come

25:27

in you know telling me that you know

25:29

they just got over a covid infection

25:31

that where they had high fevers for you

25:33

know a few weeks um and then their sperm

25:35

csed be very low and then you know we

25:38

wait a few months it takes about two to

25:39

three months to make a sperm so we let

25:41

one of those Cycles or two of those

25:42

Cycles go through and their sperm counts

25:43

came back I had a patient even before

25:46

covid uh like 41y old guy he had normal

25:50

sperm count and then all of a sudden he

25:51

measured and the sperm count had gone to

25:53

zero and it turns out he had a a flu

25:55

with fevers about 102 degrees Fahrenheit

25:58

um the week before and again we let kind

26:00

of sort of nature take his course he

26:03

recovered and then his sperm counts came

26:04

back to Baseline so we do see that um as

26:07

well with that belt that you mentioned

26:09

that it holds the sort of test testicles

26:12

closer to the body I'm guessing it's

26:13

doing that to heat them up basically

26:15

which reduces the sperm count MH

26:18

obviously then one would think about

26:19

their boxer shorts we're all wearing

26:21

very tight boxer shorts these days

26:22

that's like invogue or whatever so is

26:25

there any studies to suggest that boxy

26:27

shorts can reduce sperm count if they're

26:29

tight so that's like a very Comm that's

26:31

one of the most common questions I get

26:33

like boxers versus briefs and that's

26:35

been studied a lot because that is a

26:37

very common exposure I think I usually

26:38

just tell men whatever is comfortable I

26:40

think it's unlikely that any single

26:42

layer is going to make a big difference

26:43

unless again you have the specially

26:45

designed underwear that pushes testicles

26:47

up into the groin but otherwise as long

26:49

as they're outside the body it should be

26:51

okay what about mobile

26:53

phones and technology is there any um

26:56

link between fertility and are use of

26:58

Technology specifically having these

27:00

devices in our pockets close to our

27:02

genitals that's you know another common

27:04

question that I get um and that is

27:07

certainly something that's changed right

27:08

now versus you know 20 30 years ago uh

27:11

so there were some studies that you know

27:13

initially showed kind of this signal

27:15

that men that use cell phones more had

27:17

lower sperm count but some of these

27:19

studies were you know they're older and

27:20

you also worry about some of these kind

27:22

of confounding things it may be that

27:24

people that use phones more do other

27:25

things more you know they have may have

27:27

more stress in their life and other

27:28

things that could affect SE quality so

27:30

there was a clever study that was done

27:32

where they actually took ejaculate so

27:34

took sperm put it in a cup and put a

27:36

cell phone next to it and tried to

27:38

measure changes in you know the quality

27:39

of the sperm and they actually did find

27:41

some they found higher rates of like DNA

27:43

damage within the sperm that was exposed

27:45

to the the phone versus not you know

27:47

kind of trying to control for

27:48

temperature which we you know said is

27:50

important for the health of the sperm

27:52

wait so they controlled for temperature

27:53

they controlled for temperature and just

27:56

having kind of the cell phone you know

27:58

getting its signal um seemed to affect

28:01

you know the DNA damage in sperm it

28:03

wasn't you know it was a statistically

28:05

significant you know difference um it

28:08

maybe would not be kind of a point where

28:10

we would get as worried clinically but

28:12

it is a change so I think it's something

28:13

to think about I think that um you know

28:16

aside from that cell phones I think

28:18

nowadays don't get too hot so not as

28:20

worried about heat but whether this RF

28:22

you know this radio frequency exposure

28:24

may impact things is a you know maybe a

28:26

theoretical risk but I gu there's not a

28:28

lot of concrete data so I think that you

28:30

know again if so a lot of my patients do

28:33

tell me that they keep their try and

28:34

keep their cell phone in their back

28:35

pocket or front pocket to try and avoid

28:37

that I think that's I think that's fine

28:39

I've been having this conversation with

28:41

my partner a lot she really believes

28:42

that my cell phone should never be slid

28:45

under my genitals which I sometimes do

28:48

when I'm like I don't know when I'm in

28:49

the car or something or when I'm on the

28:51

sofa I don't know when I've got my hands

28:53

full I'll just grab it and I'll kind of

28:54

like slide it between my legs yeah and

28:56

she'll

28:58

reach in and pull it out and say and I

29:00

think because she's concerned about

29:01

those four kids that we want to have and

29:03

you I think she cares about you too yeah

29:05

I to be fair she's not someone that's

29:08

going to read PubMed and read about the

29:09

studies but it's just a feeling she has

29:11

yeah and I always refuted it and thought

29:13

now there's no way there's no way

29:15

because they would have tested it and

29:16

the test seems so easy you get sperm you

29:19

put it in a little thing you put the

29:20

phone on top of it send it some text

29:22

messages connected to the Wi-Fi the

29:23

Bluetooth and see how the sperm get on

29:26

yeah I didn't realize there was a study

29:27

asso with it yeah I think laptops also

29:31

can do that too but they also have a

29:32

little more heat associated with it so a

29:33

similar study was done in laptops um

29:36

where they had sperm put it next to a

29:38

laptop and they controlled for

29:39

temperature uh and saw the same pattern

29:42

you know again sort of the Wi-Fi signal

29:44

can also affect again sperm you know DNA

29:46

damage and sperm quality um but also you

29:49

know laptops can get warm too right some

29:51

of the batteries some of the moving

29:53

Parts within uh can heat up too and it

29:55

also just serves as almost like

29:57

insulation if you put it over your lap

29:59

so I do talk to patients about that as

30:01

well um you know to maybe use like a

30:03

pillow or something else just to try and

30:04

shield yourself a little bit wouldn't we

30:07

see a sort of big difference between hot

30:09

countries and cold countries or sort of

30:11

warm countries and sperm counts then so

30:13

if I in sort of subsaharan Africa I'm

30:16

assuming my sperm count will be pretty

30:17

low because I'm going to be sweating all

30:18

day so I think that um the other sort of

30:22

element to that though is that there are

30:23

differences in populations and I think

30:26

that that has not been well described

30:27

you know but if you compare you know

30:30

again we talked about California New

30:31

York the Midwest and the United States

30:34

but people have also compared you know

30:36

like Denmark which they have a lot of

30:38

sort of problems with reproduction so

30:40

they've really studied it very very

30:41

aggressively and if you compare them to

30:43

other countries nearby or other

30:44

countries in Europe it's much different

30:47

and so you know one possibility could be

30:50

exposures you know and what these men

30:51

are doing what they're exposed to but

30:53

the other could be you know again there

30:54

could be some genetic components but one

30:56

interesting thing about sort of on that

30:58

same line is that uh sperm quality does

31:01

vary based on uh time of year so during

31:04

the hotter months it does go down a

31:05

little bit you know not meaningfully um

31:07

and then during the cooler months it it

31:09

goes up a little bit but the other thing

31:11

is that you know we don't spend well

31:13

some of us do I guess or some of us

31:14

don't but no spend all your time

31:15

Outdoors right and sometimes in the um

31:19

you know during the the cooler months

31:21

you're you know kind of bundled up

31:22

inside and during the warmer months

31:24

you're may be in you know cool air

31:26

conditioning did you say that this

31:28

Denmark has had a problem with sperm

31:29

count yes yeah so um you know in the

31:33

United States I said that about 2% of

31:35

bursts are conceived with IVF in Denmark

31:37

it's about 10% wow um and it's actually

31:40

they they've again they have really a

31:42

crisis of reproduction there so they've

31:43

really um done some really good research

31:46

on seam quality and it estimated that

31:48

only about 25% of Danish men have normal

31:51

Sean

31:52

quality have they figured out why that's

31:55

what they're looking into and they have

31:56

lots of theories and again I think you

31:58

know again it goes to many of these same

32:00

topics that we talked about whether it's

32:02

environmental exposures on you know

32:04

mothers um or you again pubertal boys or

32:07

you know adults as well so they are

32:09

trying to figure it out but it is you

32:11

know that's also one of the countries

32:12

where the fertility rate is is below

32:15

replacement so it's definitely an issue

32:18

one would assume that it's some kind of

32:19

environmental factor I guess it could be

32:21

some other social Factor but but one

32:22

would assume that it's some kind of

32:24

environmental yeah Factor yeah some

32:26

people have postulated during World War

32:28

II they were very isolated and so

32:30

potentially there were some chemical

32:32

exposures that have just you know kind

32:33

of persisted uh and remained in the

32:35

population and it's kind of tough to

32:37

work through that but it's not

32:40

known if I'm sat down all day is that

32:43

going to have an impact on my sperm

32:44

count as well because of the heat

32:45

generated from me just sitting here um

32:48

and or if I'm a if I'm a cyclist or

32:51

someone that's doing you know sat down

32:53

on my testicles doing something warm

32:56

people have looked at sort of different

32:58

occupations where you sit a lot um and

33:00

there are associations like drivers you

33:02

know taxi drivers truck drivers they

33:05

certainly can have changes in sperm

33:06

count you know probably due to heat you

33:08

know again I think it could be a

33:10

combination of sort of sitting all day

33:11

is also you know from probably other

33:13

health standpoints is not great and

33:15

cycling too you know people have looked

33:17

at sort of peak athlete cyclist and

33:19

there are differences in Seaman quality

33:22

um but you know Peak cyclists you know

33:24

they do a lot to their body and so you

33:26

know it's possible that there could be

33:27

other effects too but you know looking

33:29

at men that sort of recreationally cycle

33:32

too I think that the number that I use

33:33

there's a study that showed um if you

33:36

cycle over five hours a week there can

33:38

be lower sperm counts so you know I

33:41

talked to men about that when they do

33:42

cycle you know more than that you know

33:44

potentially taking breaks trying to

33:46

stand up if we think the mechanism is

33:47

heat to try and sort of circulate air

33:50

out the area to spend some time out of

33:51

the saddle if possible what about men

33:53

with big thighs

33:56

yeah well I think you know obesity is an

33:59

issue there's certainly a strong

34:00

correlation between body mass index and

34:02

semen quality so as men get bigger sperm

34:04

counts go down um and so heat is

34:07

certainly one of the the possible

34:08

mechanisms for that just kind of

34:10

insulating that area warming things up

34:12

can kind of do it you know obesity also

34:15

affects you know the kind of hormonal

34:17

axis as well so that also may be at play

34:19

too because you know there's kind of a

34:21

normal stimulation that's given by your

34:24

pituitary in your brain that tells your

34:26

testicles to make sperm make testost

34:27

tone and some of that's also affected by

34:30

obesity as well so it's probably a

34:32

combination but that is something I I do

34:34

think about when I see you know my

34:36

patients and we do talk about sort of

34:37

heat exposures as well and see if

34:39

there's you different sort of strategies

34:41

they can use to try and allow more

34:43

circulation in the area is there a link

34:46

between um sperm counts and alcohol

34:49

consumption I think it depends is what I

34:52

would say so in general for most kind of

34:54

moderate use I would say kind of a drink

34:57

a day um and some people think that no

34:59

amount of alcohol you know is safe but

35:01

probably if you look at these studies

35:03

looking at maybe a drink or two a day it

35:05

probably doesn't correlate too strongly

35:06

with Sean quality but it seems like

35:08

there there are some studies say that

35:10

when men get to three a day so maybe 20

35:12

a week there can be lower quality uh in

35:15

semen and there was also another study

35:17

that we did looking at you know to see

35:19

if some men are more susceptible to to

35:21

alcohol intake so there are some um East

35:25

Asian men and women that have a mutation

35:28

and one of the enzymes that's used to

35:30

metabolize alcohol and so they

35:32

accumulate what's called acid alahh

35:34

which is a toxin actually and so when

35:36

they drink they flush I don't know if

35:37

you have any friends that have this but

35:40

um we hypothesize that you know when you

35:43

have this you know this large load of

35:44

this chemical in your body that leads to

35:46

Flushing headache dizziness um maybe it

35:49

also affects semen quality and it turns

35:50

out that it does so for these men that

35:53

have this mutation um when they drink

35:55

their sperm movement goes down a little

35:57

bit

35:58

so it turns out that there's actually a

36:00

reasonable number of men on Earth that

36:02

have this you know it's probably in some

36:04

populations up to 50% like in Taiwan um

36:07

you know it's very common in Japan you

36:10

with chinese vietnamese ancestry so I

36:13

think it's something to be aware of and

36:14

I think usually you know men do know if

36:16

they flush when they drink it's probably

36:18

because they have this mutation and Al

36:20

alahh dehydrogenase too so you know for

36:23

those men I think that it's probably

36:25

better to you know avoid alcohol or uh

36:27

just to sort of be aware because um it

36:30

can affect SE quality if I if I came

36:32

into your clinic and I said Dr Michael I

36:37

I'm trying to have a kid with my partner

36:39

and I want to make sure that everything

36:41

I'm doing is giving me the best chance

36:43

of having a kid what is what's the list

36:46

of things because this is basically

36:47

where I am at my in my life now I'm 31

36:49

years old I want to have a kid I'm

36:51

ideally want to have four of them and

36:53

I'm thinking about the time my partner's

36:54

the same age as me we're almost

36:56

identical in age

36:58

and she's 31 so we're we've got you know

37:00

we want to have these kids before 40

37:01

ideally so I kind of need to get get

37:04

going get going you know what I mean so

37:06

so what can I do to give myself the best

37:09

possible chance of increasing my

37:11

fertility my sperm count so that we have

37:14

those four kids that I want over the

37:15

next nine years was the four number it

37:18

was something you came up with before

37:19

that the tax incentive

37:23

or yeah we are planning to move to

37:25

Hungary so there you go was really it's

37:27

really about tax avoidance it's not that

37:29

I I want kids um no I come from a family

37:32

of four so for some reason I've always

37:33

had four in my head I I think she's fine

37:36

with it as well I think we've we've

37:37

we've chatted and she's she's happy with

37:39

four to six no it's a good number not

37:41

had six signed off but four for sure

37:43

what would you say to me then so I think

37:45

you know we look at you know your

37:47

overall health um you know we' see any

37:50

risk factors you had obviously we're

37:51

talking about saunas hot tubs find out

37:53

you know how you exercise if there's

37:55

things that you do that are not you know

37:57

good

37:58

um look at you know if any medical

37:59

conditions that you have surgeries that

38:01

you've had some of those can put men at

38:02

risk for for that if there's any

38:04

medications you're on there can be

38:06

medications that affect it and then

38:07

we'll do an exam um so we don't have to

38:10

do that here in front of the

38:11

cameras I'm

38:14

down U I do have yeah I do have a

38:16

California medical license but um so you

38:19

know we want to make sure we look at the

38:20

sides of the testicles make sure all the

38:22

other structures are where they're

38:23

supposed to be um you know one of the

38:25

basic evaluations will be a seman

38:26

analysis so we'll measure how much comes

38:28

out look at how many sperm there are

38:30

look at how many are moving look at

38:31

their shape as well and then usually we

38:33

also check hormones as well so we'll

38:35

check testosterone again sort of this

38:37

very male hormone the testicle does two

38:38

things it makes sperm makes testosterone

38:40

so we check that and then usually we

38:42

check some other hormones involved in

38:43

the kind of hormonal axis that controls

38:45

reproduction and that's usually what we

38:47

start again fertility is a team sport so

38:49

I would encourage your partner to also

38:51

get evaluated as well um and we'd see

38:53

you know depending on kind of sperm

38:55

counts usually then we're able to sort

38:56

of counsel about you know how likely you

38:58

are to be able to achieve um you know

39:00

those four kids but you know again it if

39:02

you're kind of thinking about four I I

39:04

would agree that you should get

39:07

started fertility issues we tend to

39:09

think of it I think there's a stereotype

39:11

that it's typically the woman who has

39:12

the fertility issue and and the man is

39:14

okay and I think if you when I looked at

39:16

the data that it that's kind of

39:17

supported this idea that couples assume

39:20

it's the woman that has the fertility

39:21

issue is that a misconception it's a

39:24

huge misconception yeah so absolutely I

39:26

think that you know in United States and

39:29

other countries too I think usually you

39:30

know women are kind of the gatekeeper of

39:32

fertility everybody assumes that that's

39:34

where the issue lies but if you actually

39:36

look at you know the data probably about

39:38

half the time there's a male Factor

39:40

contributing and you know this sort of

39:42

stereotype is so prevalent that probably

39:44

at least a quarter of the time in the

39:46

United States the man's never evaluated

39:48

and he could be you know one of the

39:49

issues so some couples may go to IVF you

39:52

know for the lone reason of you know

39:54

again low sperm count and the man would

39:56

never evaluate it and maybe there is a

39:57

condition that we can improve maybe he's

39:59

on a medicine maybe you know he's going

40:01

to the jacuzzi every day you know

40:03

something like that that we be able to

40:04

reverse you mentioned testosterone would

40:07

be one of the things that you would

40:08

measure if you were trying to make sure

40:09

that my fertility was good male

40:12

testosterone decline this is another Hot

40:15

Topic you talked about it at the start

40:16

of this conversation is it true that

40:18

male testosterone is declining and how

40:20

much has it declined by yeah so um again

40:24

study from this enhan this CDC you know

40:27

measuring men every year for the last

40:28

several decades if um you know there's

40:31

data that shows that testosterone levels

40:33

have have gone down over time you know

40:35

people have also looked at um you know

40:37

other cohorts of men you know from the

40:39

2000s the '90s 80s and there's just a

40:42

progressive decline in average

40:43

testosterone levels over that amount of

40:45

time so you know the amounts you know

40:48

kind of vary 50 to 100 points but you

40:49

know generally these are you know

40:51

meaningful measurable amounts in

40:53

addition to sort of these kind of cohort

40:55

changes where if you kind of you know

40:56

look at the average 40-year-old Now

40:58

versus you know 10 years ago our our

41:01

testosterone levels change too so I

41:03

would say that I usually tell men after

41:04

the age of 20 your testosterone is going

41:06

to go down maybe about a percentage

41:07

point every year so as we get older

41:09

testosterone does go down and there's

41:11

things again that can affect that

41:12

trajectory you know men that get more

41:14

obese that also affects testosterone

41:16

level a portion of all of our

41:17

testosterone is converted to estrogen a

41:19

lot of that conversion happens in you

41:21

know adapost tissue or fatty tissue so

41:23

the more kind of extra tissue there is

41:24

in the body the more that conversion

41:26

will happen and so your you know

41:28

effective testosterone levels will be

41:30

lower what about movement and exercise

41:33

does that have an impact on our

41:34

testosterone levels in a significant way

41:37

yeah I mean I think that you know the

41:38

more walking you do the more active you

41:41

are we've looked at that as well you

41:43

know step count is directly correlated

41:45

to testosterone and you don't have to

41:46

take 20,000 steps a day you know 4,000

41:49

8,000 steps a day you know just kind of

41:51

walking around you know sort of

41:53

reasonable amounts it can make a big

41:54

difference and I think that um you know

41:56

activity is important it probably also

41:58

helps Dave off obesity a little bit as

42:00

well as another mechanism okay so I'm a

42:02

Manchester United fan right now we're

42:03

losing a lot I thought you guys have

42:05

turned it around yeah I thought so too

42:07

until last week okay so if you're if

42:09

you're supporting a team that is losing

42:12

your testosterone levels likely going to

42:13

be lower well I think this is sort of an

42:16

acute thing maybe we could do that

42:18

experiment right where does that that

42:20

research come from that if your team

42:21

wins your testosterone increases I don't

42:23

remember I I that stud is pretty old I

42:26

think that even dated my um training but

42:29

I do remember reading that I think that

42:30

was one of the articles that get picked

42:31

up by the newspaper okay of course why

42:35

why does testosterone

42:36

matter well I think testosterone is very

42:38

important for you know a lot of things I

42:40

think it's it's important for our

42:43

quality of life so energy level sex

42:44

drive mood sleep concentration all those

42:47

things are very important um when

42:48

testosterone gets very low it also has a

42:50

lot of Health implications so muscle

42:52

Health bone health heart health so we do

42:55

want to keep our levels in a normal

42:56

range um because I think it yeah kind of

42:59

helps us with our function and our life

43:03

uh and happiness how how does the impact

43:05

our sort of muscles and Bones I don't

43:07

really understand what testosterone is

43:09

doing I I kind of think of it as the

43:10

chemical that kind of makes you a man I

43:12

know women have testosterone too but I I

43:14

just think of it's the chemical that

43:16

makes my beard grow in my voice deep

43:18

yeah well that's what it's doing but

43:19

it's anabolic it does help kind of grow

43:21

it helps with bone turnover um and kind

43:23

of keeps sort of uh you know the

43:25

strength of the bone so men that have

43:26

very low testosterone levels have you

43:29

know frailer bones higher risks of

43:30

osteopenia

43:31

osteoporosis so um you know I think it

43:35

helps with muscle growth bone turnover

43:39

bone strength so I think all those

43:41

things are um are important they usually

43:44

don't get into those problems unless men

43:45

are very very low I would say that you

43:47

know I don't know you but you know the

43:49

average testosterone levels are probably

43:51

300 to 900 I would guess probably on the

43:53

higher higher end of that um but you

43:56

know when are low probably less than 200

43:58

100 that's where we start to worry more

44:00

about you know bone health muscle health

44:03

and so I think that there is some wiggle

44:05

but when you get kind of lower than sort

44:06

of the normal ranges kind of the 300

44:08

range that's when some men do develop

44:10

you know some of the symptoms of lower

44:11

energy level sex drive problems things

44:13

like that so low testosterone typically

44:15

means lower sex drive uh it can it's one

44:18

of the it's one of the common symptoms

44:20

that we see with that does that mean

44:22

that if I just take loads of

44:23

testosterone my sex drive is going to go

44:24

back up you know over the last probably

44:27

10 to 20 years the number of

44:28

prescriptions of testosterone written in

44:30

the US have kind of gone up almost at an

44:32

exponential rate and because people did

44:34

think of it sort of as a um kind of an

44:37

anti-aging kind of Rejuvenation therapy

44:39

and so there was hope that it would help

44:41

people but if you look at some of the

44:42

randomized trials if a man has a normal

44:44

testosterone level and you give him

44:45

testosterone uh it may not help him that

44:47

much even men that have kind of a lowish

44:49

testosterone like we talked about sort

44:50

of this 300 cut points so I've had

44:52

plenty of patients testosterone of 250

44:55

let's say so we talk about risks and

44:57

benefits of being on testosterone uh

44:59

we'll try them on it and you know a lot

45:01

of men do feel better but not everybody

45:03

some men I don't feel any you know doc I

45:04

don't feel any different even though he

45:05

get his levels you know from 250 to 500

45:09

um and so then it's probably not worth

45:10

you know to be on a medicine every day

45:11

if it's not helping you I'm not worried

45:13

about his bone health you know we'll

45:14

check some other measures to make sure

45:15

that's okay um so then it's not you know

45:18

again when you look at risk and benefits

45:19

it's probably not worth it but there's

45:20

certainly some men who do who do see

45:22

Improvement so is testosterone hurting

45:25

some people their testosterone treatment

45:28

does it actually have an adverse effect

45:30

if you take it basically when you don't

45:32

need to I mean even when you do need to

45:34

I think it could C sometimes cause

45:36

issues yeah there's certainly side

45:37

effects to testosterone um you know one

45:39

of the big things that I see in my

45:41

practice is how testosterone impacts

45:43

sperm production um it actually was

45:45

tested as a contraceptive by the World

45:47

Health Organization because it does low

45:49

lower sperm counts in most men I would

45:51

say 90% of men now it doesn't do 100% so

45:54

it's not that great of the contraceptive

45:56

yet they're kind of working on some

45:57

other ways to tweak it um but I have

45:59

plenty of patients that come in you know

46:01

some of them suspect that testosterone

46:03

is the issue some don't know um I

46:04

remember one couple in particular they

46:06

came in as a couple together you know we

46:08

measured his sperm count it was Zero we

46:10

started talking about risk factors and

46:11

he was on testosterone I said well the

46:13

best thing to do would be to stop

46:15

testosterone um and for his work I'm

46:17

going tell you what he did but for his

46:19

work he really couldn't stop it um so

46:21

there's some other medicines we were

46:22

able to add while he continued the

46:25

testosterone um and then and then they

46:27

ended up with triplets um shortly

46:29

thereafter so I think that you know men

46:31

need to be aware of it um because that's

46:34

you know certainly one of the big risk

46:36

factors at least of reproductive age men

46:38

is this risk to

46:39

fertility so it can impact my sperm

46:41

count negatively um I I I saw a quote

46:44

from you that said if we take a hundred

46:46

of my infertile patients that I see in

46:48

the clinic at least five of those men

46:50

will be infertile because they're on

46:51

testosterone therapy one in 20 infertile

46:54

men are that way because of testosterone

46:58

as it relates to infertility one of the

47:00

things that I've always worried about is

47:01

if I take

47:03

testosterone then my hair would fall out

47:07

yeah so that can do definitely happen so

47:10

you know hair loss breast growth acne

47:12

those can all occur I would say those

47:14

are things that we can monitor so you

47:16

know one thing I always tell men is that

47:17

we're not trying to get them to superum

47:20

right we're just trying to get you to

47:21

normal so I think if we monitor it

47:22

closely most men you know will do okay

47:25

again there are some other therapies

47:26

that we can do for men that have side

47:28

effects uh you know from those things it

47:31

can also affect the thickness of the

47:32

blood something called the hematocrit or

47:34

we count the number of red blood cells

47:35

in the body it can increase that number

47:37

so if it gets too high that can be an

47:39

issue so that's another number that we

47:40

follow there used to be a concern about

47:43

um higher rates of heart attack and

47:45

stroke with testosterone so there were

47:48

some studies done um you know about

47:50

maybe 10 year five 10 years ago that

47:52

suggested that but a really large trial

47:54

just came out uh with about 5 200 men

47:58

half of them randomized to testosterone

47:59

half not and there was actually no

48:01

difference in the risk of cardiovascular

48:02

disease so I think that's something that

48:04

we can probably put to bed the other

48:06

thing that men worried about is increase

48:07

of risk of prostate problems prostate

48:10

cancer prostate growth and you know that

48:12

same trial also showed that um from a

48:14

prostate standpoint probably not a lot

48:15

of risk as

48:16

well do you have many men coming to you

48:19

to talk to you about hair loss and

48:21

Bolding uh some men do I think one of

48:24

the ways that men talk to me about it is

48:25

one of the common medication for that is

48:27

finasteride right or you know sold on

48:29

the trade name propa um and so they want

48:31

to understand some of the risks of that

48:34

and so you know when that medicine was

48:37

approved for a hair loss they you know

48:40

again because people that are going to

48:41

take it are usually in the reproductive

48:42

age they did randomized Placebo control

48:45

trials to look at semen quality and it

48:47

turns out that it didn't meaningfully

48:49

impact things maybe it went down a

48:50

little but not a lot um but in sort of

48:53

post um you know analyses of some of

48:55

this and now seeing lots of patients

48:57

coming in we do see men that are on

48:59

finasterid some of them are more

49:00

susceptible and so one of the

49:02

interesting thing about trials is

49:03

there's you know kind of inclusion and

49:05

exclusion criteria right not not

49:06

everybody can be in it and so if men had

49:09

sperm counts that were too low they

49:10

weren't invited to be in these trials so

49:13

for men that you know don't have as much

49:14

Reserve as others I think they may be

49:16

more susceptible so that's one of the

49:17

risk factors finasteride you know the

49:19

other thing in aash in addition to

49:21

reproductive health is sexual health

49:22

that I deal with a lot and there's also

49:24

a concern that finasteride impacts

49:26

sexual function function in men too so

49:28

you know we have these discussions I've

49:29

had some men that come in after having

49:31

been on finasterid and have you know

49:33

different issues with sexual desire low

49:36

liido or rectile dysfunction and so then

49:38

we you know work through an algorithm to

49:40

try and improve that as well this is one

49:42

of the things I think about a lot

49:43

because I don't want to I don't want to

49:44

have a receding hairline and I also

49:46

don't want to have a air operation or

49:48

anything like that but when I hear about

49:50

some of these testosterone replacement

49:52

therapies and and such my big concern is

49:54

that if I take testosterone maybe not

49:56

now cuz I'm you know probably don't need

49:58

it right now but maybe when I'm a little

49:59

bit older which is when I assume one

50:02

would start taking it maybe when I'm

50:03

about 50ish on average but there are

50:05

younger men that are on it as well for

50:07

what reason just because they're low

50:10

on what's the sort of symptoms that that

50:12

have caused them to take it well I think

50:14

there's you know with all things there's

50:16

a bell-shaped curve so some men are a

50:17

little bit lower some have genetic

50:19

conditions you know there are um some

50:21

more nefarious testosterone prescribers

50:23

so even though men have a normal level

50:25

they're offered testosterone to kind of

50:27

get in these kind of testosterone

50:28

clinics and some men you know if kind of

50:31

look at data maybe 10 to 20% of you know

50:35

high school athletes have experimented

50:37

with testosterone and if you stay on

50:39

that too long it can really shut down

50:40

your own axis so um if you take

50:43

exogenous testosterone so like

50:45

testosterone injections or gels your

50:47

body stops making it and the longer

50:49

you're on it the less likely your body

50:51

is able to sort of restart and so for

50:53

some of these men you know poor choices

50:56

or or whatever they've been on

50:58

testosterone for a while and they can't

50:59

ever stop I don't know if you've ever

51:01

had any experience in it because I know

51:03

you focus predominantly on male Health

51:04

but um I've had a long conversation

51:07

about contraceptive pills with my

51:09

partner because she was on she said this

51:12

publicly before that she was on a

51:13

contraceptive pill for a long time and

51:14

then and everyone's relationship with

51:16

contraception is different but after

51:18

taking it for seven or eight years she

51:20

she came off it and her period didn't

51:23

happen didn't occur so she really

51:26

struggled with that for a while

51:28

previously and it made me really you

51:29

know it illuminated the fact that when

51:31

we start messing with the chemical

51:32

balances of our body using pills and

51:35

injections and other things we could do

51:37

pretty long-term Andor permanent damage

51:40

to ourselves and there's no real such

51:41

thing as a free lunch is there in

51:44

biology and chemistry yeah I think

51:45

that's what it comes down to I think a

51:47

lot of people have said that if they

51:48

tried to get the uh the pill approv now

51:51

it would be a much different process and

51:53

unlikely to succeed for those kind of

51:55

reasons if I have low

51:58

testosterone um and I come to see you

52:03

what is the typical way of getting a

52:06

testosterone replacement therapy is it a

52:09

pill is it an injection that I have to

52:11

take um I know that it's quadrupled

52:14

according to the data in the US since

52:15

two since the 2000s which is staggering

52:18

but how are people taking testosterone

52:20

so there's lots of different ways it can

52:22

be taken I think one thing you know

52:23

again we talk about all the risks so

52:25

fertility is certainly be you know a big

52:27

one so if you come in in your 30s you

52:30

know I'd ask you about your reproductive

52:31

intent so if you have a low testosterone

52:33

and you're interested in having four

52:34

kids I wouldn't start you on

52:36

testosterone directly there's some off

52:38

label things um you know so medicines

52:40

that we kind of repurpose to help

52:41

increase your body's own testosterone um

52:44

that we would start with but assuming

52:46

that let's say you're in your 60s you're

52:48

not interested in fertility then you

52:50

know there's gels or patches that you

52:51

put on every day testosterone gel or

52:53

patch um because that can work well

52:55

probably 10 to 20% of men don't absorb

52:57

testosterone that well through the skin

52:59

the other thing to be aware of is that

53:00

there's a risk of um like transference

53:03

like to your partner to anybody that

53:05

kind of touches your skin so if you have

53:06

young kids just to sort of be aware of

53:08

but as long as you know you put it on

53:10

let it dry put clothes on over it it's

53:11

not a big risk um you know again and

53:15

also have to be I guess mindful of

53:16

laundry as well uh so you know gel's

53:19

patches are one there's injections uh

53:21

that you can do every usually one to

53:24

three weeks on average there's testost

53:26

pellets um so these are pellets that

53:29

have testosterone they're kind of slow

53:30

release so um they're just injected uh

53:34

we kind of implant them under the skin

53:35

usually in the hip area and those last

53:37

probably 3 to six months there's longer

53:40

acting injections so those are very

53:41

common in Europe um they're kind of

53:43

gaining steam in the US but those are

53:46

injections that last probably 10 weeks

53:48

or so and then there's a new oral

53:50

therapy so there's an oral form of

53:52

testosterone um that's available as well

53:55

I was quite confused on this subjec of

53:56

hair loss in testosterone because I

53:58

couldn't figure out if low testosterone

54:01

causes me to bold and have a receding

54:04

hairline or if it's high testosterone

54:06

that causes me to bold and have a

54:08

receding hairline or if it's both I mean

54:11

it could be both I think usually we

54:12

think about it as um as higher levels

54:15

okay it's funny because I've I've

54:16

wondered before whether me doing a lot

54:18

of exercise which is I guess increasing

54:20

my testosterone levels is going to

54:22

accelerate my Bolding in receding

54:24

Airline anything that's good for your

54:26

heart should be good for your hairline

54:27

so I would exercise I think that's good

54:30

but what if I'm doing like Iron Mans and

54:32

Thousand Mile runs and all that kind of

54:33

thing which you see in in certain groups

54:36

so I don't know that it I I do think

54:38

it's possible to OV exercise I don't

54:40

know if it'll affect your hairline but

54:42

um you know I testosterone levels it can

54:46

affect testosterone levels I do think

54:47

that it's you know when you kind of

54:49

exercise to the point of exhaustion you

54:51

know we do see declines in sperm counts

54:53

as well so hormone levels can certainly

54:55

be affective did um CU my cortisol goes

54:58

up so my testosterone I'm I guess goes

55:01

down can go down sometimes interesting

55:04

what about penis size I heard you did

55:06

some pretty Landmark research which

55:08

suggests that the length of a man's

55:10

penis is increasing decade over a decade

55:12

in terms of um men that are being born

55:15

and boys that are going through puberty

55:18

yeah so um this this study also got a

55:21

lot of attention so um you know similar

55:23

to how we've tracked testosterone levels

55:25

over time or sperm counts over time you

55:28

know for different reasons investigators

55:30

have measured penal length you know to

55:32

kind of give normative data across

55:33

different populations to understand how

55:35

different surgeries or conditions may

55:37

affect um penal length so you know we

55:40

looked at you know all the studies and

55:42

there were there were dozens and so we

55:45

kind of pulled all that together this

55:47

was tens of thousands of men and just

55:49

looked at sort of average pile length

55:50

over time and so you know again based on

55:53

some of the data on Seamon quality we

55:55

would have expected things to get

55:56

shorter over time and also because we're

55:58

more obese now you know the way that

56:00

penises are measured is you kind of pull

56:02

the penis on stretch and use a tape

56:03

measure some sort of ruler measuring

56:05

device so if the there's kind of more

56:07

gut you know more fat in theory length

56:10

should be a little bit shorter now than

56:11

it used to be um but it turns out at

56:14

least when you measure a Rec penile

56:15

length uh that penises are longer now

56:17

than they used to be uh and so over the

56:20

you know past 30 years or so they've

56:21

probably gone up about

56:23

25% why I mean it's it's a good question

56:27

I think one hypothesis we had kind of

56:29

looking at sort of different endocrine

56:31

you know abnormalities um and changes in

56:34

puberty is that if men go through

56:36

puberty or boys go through puberty

56:38

earlier that tends to correlate with

56:40

longer penis length and so if we are

56:43

shifting puberty again through these

56:45

different environmental exposures maybe

56:47

that is leading to you know changes in

56:49

general development and this may be one

56:51

of the consequences of it does this have

56:53

any Upstream like implications for

56:56

for sex I think that well the numbers

56:59

we're talking about shouldn't be um you

57:02

know kind

57:03

of enough to make a big big difference

57:06

um you know people as this study came

57:09

out we talked about you know very

57:10

enterprising patients kind of reaching

57:11

out sending emails some people

57:14

hypothesize that this was kind of

57:15

natural selection so it's it's hard to

57:17

know um but again it's it's a very short

57:19

period of time so it's hard to believe

57:21

that there's you know that's kind of at

57:23

play do you have many people that come

57:25

into your practice that are with

57:26

erectile dysfunction yeah so that's

57:29

another very common condition we see you

57:30

if you look at men over the age of 40

57:32

over half have some trouble with

57:33

erection so very very common hundreds of

57:36

millions of men all over the world are

57:39

afflicted we don't talk about this much

57:43

um what what is the cause of this and

57:46

are you seeing it increase over time the

57:48

the prevalence of erectile dysfunction I

57:50

mean I think the rates are going up and

57:52

I think you know the risk factors you

57:54

know are the same risk largely the same

57:56

risk factors that affect heart disease

57:58

so you know diabetes obesity high blood

58:01

pressure high cholesterol you know

58:03

minority of these um conditions can be

58:05

caused by low testosterone sometimes the

58:07

outcomes of you know surgical treatment

58:09

for pelvic cancers as well um but by and

58:12

by and large it's vascular just it's a

58:14

blood flow issue because I used to think

58:17

it was more of like a like a hormonal

58:19

thing or a psych psychology thing like

58:22

you know sexual anxiety or some kind of

58:24

you know change to our testosterone

58:27

levels is causing us to struggle with

58:28

getting erections now you're saying it's

58:31

about so I think you know psychogenic

58:33

used to be thought of like you're saying

58:35

used to be thought of as the kind of the

58:36

primary ideology um and maybe for some

58:40

you know populations it could be a

58:42

little bit more common but generally for

58:44

most men sort of all crummers it's going

58:46

to be a blood flow issue a vascular

58:47

organic cause and how would you get

58:49

about treating um erectile dysfunction

58:53

um so there's a lot we can do we do want

58:54

to you know kind of reverse anything

58:56

that we can kind of understand where the

58:58

man's coming from find out if there's

58:59

you know new relationship or other kind

59:01

of factors you know for men like you

59:03

know suggesting that we do s like kind

59:05

of suspect a psychogenic component work

59:07

with sex therapists as well um but for

59:10

other men you know I always like to be

59:11

very positive it's like to say you know

59:13

as long as you have a penis we can

59:14

always make it hard so there's a lot

59:16

that we can do so usually we start with

59:18

pills um like bagra sealas does that

59:21

work for people it works probably 60 to

59:23

70% of the time so that does work well

59:26

um even for men with a psychogenic cause

59:28

sometimes it can kind of help reset the

59:29

system a little bit you know convince

59:31

them and their body that everything is

59:32

working well like a placebo effect well

59:35

it's I think to some extent but even

59:37

more than that because it does work it

59:39

does help and then I think once they

59:41

kind of regain that confidence if there

59:42

was some sort of traumatic event

59:44

traumatic relationship it can help um

59:46

improve things pills aren't enough or

59:48

they don't like those or they have side

59:50

effects from those um there's other

59:51

therapies so there's medicines you can

59:53

actually put in the tip of the penis

59:55

like a gel or a repository we can teach

59:57

men to give themselves injections in the

59:59

penis oh I just got shiver my bu there's

60:03

certainly a uh a kind of a a

60:05

psychological um sort of fear of that

60:07

but it does work well probably works 80

60:09

to 90% of the time um there is something

60:12

called a vacuum erection device so it's

60:14

like a plastic cylinder you put over the

60:16

penis that sucks blood into the penis

60:18

kind of treats it like a balloon and

60:19

then you put a band at the base to trap

60:21

blood inside um and there's even surgers

60:23

we can do to put a device inside the

60:25

penis so whenever want whenever a man

60:26

wants to be hard he can be hard I didn't

60:29

know there was surgery you could do it a

60:31

surgery mhm what does that do it puts a

60:34

so there there's two main flavors of it

60:36

there's um or forms maybe that's a

60:38

better term uh there's one called a

60:40

malleable so it's bendable so it kind of

60:41

puts this sort of bendable um metal it's

60:44

a metal core with sort of a plastic um

60:46

kind of covering so when they don't want

60:48

to have sex you bend it down when you're

60:49

ready for sex you bend it up um or

60:52

there's inflatable versions so when

60:54

you're whenever you're ready for sex

60:55

there's uh basically a pump that goes in

60:57

the scrotum and you just Pump It Up and

60:59

moves fluid into the cylinders and

61:00

you'll get a rigid

61:02

erection is that increasing in

61:05

popularity I think you know there it's

61:08

made by a few manufacturers in in the US

61:11

or in the world um and I so I think the

61:14

data is not as freely available I mean

61:16

in my practice I've seen more and more

61:18

of it um we're seeing more patients come

61:20

in I also say that you know my practice

61:23

is getting a little bit more mature with

61:24

time as I get older and so you know

61:27

naturally you know more patients kind of

61:29

hear about these different things but it

61:31

does work well I always say it's a self-

61:32

selected population right we don't hold

61:34

men down and force them to get it but

61:36

generally they're very happy probably

61:37

90% of men are very happy they'd

61:40

recommend it to their friends Partners

61:42

very happy recommend it to other couples

61:44

and you just you press a button and you

61:45

get like a you can it's a pump right now

61:48

they are working actually on um either a

61:51

fob or like a phone app that'll kind of

61:53

automatically inflate it to make it

61:55

easier for Pati I had no idea it sounds

61:58

like sci-fi or something it sounds like

62:00

it's

62:01

um sounds like something you might see

62:03

on like a YouTube video that people are

62:04

working on in like 20 30 years time but

62:06

to to know that men have that installed

62:09

now is amazing yeah yeah the I mean it's

62:12

uh yeah it's very common um the youngest

62:15

patient I put it in is about 20 the

62:16

oldest is in his 80s what was the is it

62:19

seen as like a last option in the that

62:23

menu of options that you presented there

62:24

where like the first option probably

62:26

Viagra and in terms of popularity is it

62:28

a last port of core I think for a lot of

62:31

men it's the most aggressive but some

62:32

men don't want to do like you had a

62:34

reaction to the injection I think that's

62:35

a very common reaction there are

62:37

certainly some advantages to it compared

62:39

to others you know for Viagra for

62:41

example even though it's obviously the

62:42

easiest it's a pill you know there's

62:44

some side effects with it and there's

62:46

also you know a lag time right you have

62:48

to take the pill wait an hour wait 30

62:49

minutes something like that whereas this

62:52

you know the penal prosthesis you know

62:55

if you just pump it up it's ready to go

62:57

in seconds so it can be very spontaneous

62:59

so patients like that um you know some

63:02

patients don't you know they have other

63:04

medications so they can't take pills

63:06

they don't like some of the other kind

63:07

of intermediate options that we have

63:10

shock wve therapy for erections does

63:12

that work and what is it so the idea is

63:16

that um as kind of the name implies

63:17

you're sending shock waves into the

63:19

penis um and the energy is induces kind

63:22

of some microt trauma which induces new

63:24

blood vessel growth is the

63:26

hypothesis and so you know the hope is

63:28

that with you know getting better blood

63:31

vessel better blood flow into the penis

63:33

can improve the quality of erections so

63:35

there have been some studies that do

63:37

show benefit it's still considered

63:38

experimental um because I think the data

63:40

is not yet conclusive but I think for

63:42

men with milder forms of erectile

63:44

dysfunction it can help you know maybe

63:46

the men that are on Viagra or sometimes

63:48

on Viagra may we can get them off those

63:50

pills um but I think we need more data

63:53

uh to kind of understand really the kind

63:55

of best Target population for it you

63:57

talk about pelvic flaws as well um when

64:01

we typically think about pelvic flaws we

64:03

tend to think of women you know things

64:05

like these keegle exercises that people

64:07

talk about but is it important for us to

64:10

think about that as a man as well our

64:12

sort of pelvic floor strength and our

64:14

pelvic floor muscles I think in some

64:16

conditions I think if you're not

64:17

thinking about it it's probably okay

64:18

you're not having a lot of problems um

64:20

but it can be a trigger for some men so

64:22

that can be an ideology of some

64:24

different um like problems with

64:26

urination you see men with very tight

64:28

you know pelvic floors and they have a

64:30

lot a lot of urgency to urinate they

64:31

urinate frequently can also lead to

64:33

scrotal pain sometimes as well um

64:35

because there's a lot of muscles as

64:36

you're kind of pointing out in the area

64:38

and sometimes if they're under tension

64:40

um if they're not um you know properly

64:42

kind of trained and they're they can

64:44

kind of trigger some other areas and so

64:46

um for some of these different

64:48

conditions um we do kind of work with

64:50

pelvic floor physical therapists to

64:52

train patients you know how to you know

64:54

again relax the area strength in the

64:55

area increase flexibility of some of

64:57

those muscles which can help is it

64:59

plausible that doing pelvic floor

65:01

exercises will improve one's sex

65:03

life I mean I think that unless we're

65:07

treating a problem I would be very

65:09

hesitant you know one of my favorite

65:11

saying is the enemy of good is better so

65:13

if things are good you know to try and

65:16

get better you know there always there's

65:18

always going to be like you said there's

65:19

no free lunch there's always some

65:20

trade-offs so I think if you work on

65:23

kind of over strengthening the pelvic

65:24

floor it could lead to of these other

65:26

dysfunctions so you don't want to end up

65:28

with a floor that's too tight or too

65:29

tense is there any correlation between

65:32

these things like your pelvic floor

65:34

strength your testosterone your sperm

65:35

count and a variety of the different

65:38

cancers that we see in men things like

65:41

testicular cancer and prostate cancer so

65:44

um I think with with uh pelvic floor

65:48

kind of strength I think I usually kind

65:50

of think about that as separate from uh

65:52

cancer risk but for test cancer you know

65:55

one of the risk factors for that is some

65:57

men are born without testicles in their

65:58

scrotum uh so that's a risk factor an un

66:01

so-called undescended testicle low sperm

66:03

counc associated with testicular cancer

66:05

there was one study I know of years ago

66:07

that looked at um you know comparing

66:09

sort of sexual health to prostate cancer

66:11

risk found that men that ejaculated more

66:13

frequently had lower risk of prostate

66:15

cancer the thought was that you know

66:17

there was inflammation that you're kind

66:18

of clearing out by frequent ejaculations

66:20

I think this study had men ejaculating

66:23

30 times a month and showed a lower risk

66:25

so that's

66:26

that's a lot um but that was one study

66:29

that said at least it's not dangerous to

66:30

ejaculate more frequently but it's not

66:32

something that I generally recommend to

66:33

men to lower their risk if we talk about

66:36

testicular cancer then um what are the

66:38

the common symptoms of testicular cancer

66:41

yeah so usually it tends to be

66:42

relatively asymptomatic I think that you

66:44

know the classic symptom would be a firm

66:47

painless mass that men find in the

66:48

scrotum so if you know um there used to

66:51

be there are screening guidelines um

66:54

even though our preventative Services

66:55

Task Force thinks that you know the

66:57

utility of doing it for you know

66:59

reproductive ageement to their scrotums

67:02

may lead to more anxiety than actually

67:04

you know Finding test this cancer

67:05

because it's such a rare cancer so it's

67:07

more likely a man's going to just worry

67:09

themselves than actually you know

67:11

diagnose in early cancer but the

67:13

recommendations used to be that you

67:14

would you know once a month in the

67:16

shower kind of feel yourself and if you

67:17

feel something new or something abnormal

67:19

you know bring it to your doctor's

67:20

attention you I certainly see a lot of

67:22

men with this concern do an exam say you

67:24

know that's normal or if there's

67:26

something that we're worried about um

67:28

we'll kind of dive a little deeper what

67:29

is the demographic that are most likely

67:32

to get testicular cancer is it something

67:34

that affects young people as well as

67:35

older people it's usually mostly a

67:37

cancer of young men so I would say

67:39

probably 20s to 40 uh is usually the the

67:41

kind of the Prime demographic why is it

67:44

a cancer of young men is there any sort

67:45

of physiological reason for that well I

67:47

mean it's a you know reproductive age

67:49

cancer so that's the prime reproductive

67:50

years um so it's possible that it kind

67:53

of correlates with you know sperm C

67:56

declining with older age there is

67:57

another slight increase for men in their

67:59

50s and 60s um but again it's such a it

68:03

is a very rare cancer so I usually kind

68:05

of quote probably one in 100 thousand

68:06

men um are going to be diagnosed with it

68:09

so one in 100 thousand it's pretty it's

68:11

fairly uncommon but prostate cancer is

68:13

more more common prostate cancer is more

68:15

common yeah so that we you know in the

68:17

United States probably at least 200,000

68:19

men every year um some studies say that

68:22

you know if you live long enough

68:23

everybody will be diagnosed with

68:24

prostate cancer but again most men with

68:27

prostate cancer die of heart disease

68:29

just like every other man in this

68:30

country so most men you know with

68:32

prostate cancer die with it not of it um

68:34

so usually it's a slower growing disease

68:36

although there's some that are more

68:37

aggressive and that's why we screen for

68:38

it and treat it I read a stat that it

68:41

affects one out of every seven men

68:43

prostate cancer yes okay so what is a

68:46

prostate so a prostate is it's a walnut

68:49

shaped organ yeah um it's just

68:52

underneath the bladder so the way that

68:53

we're shaped is we have our bladder

68:55

which FS with urine from our kidneys and

68:57

then we urinate out the urethra you know

68:59

out the penis um and so the prostates

69:02

just at that kind of intersection

69:03

between the urethra um and the bladder

69:07

and it really has a function in

69:08

reproduction so it produces about 20% of

69:11

the fluid of our ejaculate and it

69:13

produces a lot of the different

69:14

chemicals and sugars that support um and

69:18

protect the sperm in the female

69:19

reproductive tract so after reproduction

69:22

it doesn't really have a lot of you know

69:24

benefit mostly it just causes issues

69:25

because it gets bigger with age so it

69:27

leads to urinary symptoms and then

69:29

obviously it it's a cancer risk as well

69:30

as we get older okay so we typically get

69:33

prostate cancer once we've stopped using

69:36

the prostate for reproduction yes so

69:39

does it have a role outside of

69:40

reproduction I guess because it's a

69:42

gland it might be regulating hormones

69:44

long long after we're using it for

69:45

reproduction reasons uh it doesn't

69:47

really have any useful benefit if we

69:49

could find a way to remove the prostate

69:51

without causing any complications that'd

69:53

probably be a reasonable thing to do but

69:55

unfortunately every treatment we have

69:57

does have some uh some side effects just

69:59

given where it is anatomically it's

70:00

right by a lot of the structures are

70:02

important for erections and for

70:03

reproduction so when people have

70:05

prostate treatment because they've got a

70:06

prostate cancer are they getting their

70:08

prostate removed some men get it removed

70:10

some men um have radio therapy um to

70:13

sort of kill all the prostate cells and

70:15

there's other kind of energy therapies

70:16

that are delivered like um highfrequency

70:19

ultrasound can sometimes be delivered

70:21

there's also something called

70:22

cryotherapy where you can freeze the

70:23

prostate you know usually these are done

70:25

in kind of targeted Fashions where you

70:27

can look at the prostate look at MRI

70:29

imaging of the prostate um look at

70:31

biopsy patterns to try and figure out

70:32

where the cancer is so usually the whole

70:34

gland is treated but sometimes you know

70:36

I think newer modalities are trying to

70:38

just treat you know a particular portion

70:40

how often do you think we should get our

70:42

prostate checked and what are the

70:44

symptoms that we should be looking for

70:46

from a sort of a urinary standpoint I

70:49

think that if urination bothers you you

70:51

should talk to your primary care doctor

70:52

or your urologist about it you know if

70:54

you're waking up at night if you feel

70:55

like you have to pee too frequently if

70:57

it burns to pee things like that um so

71:01

and that sometimes is due to prostate

71:02

enlargement prostate issues it could

71:04

also be due to a tight pelvic floor as

71:05

well from a cancer standpoint usually we

71:08

check uh blood tests called a PSA

71:10

prostate specific antigen and you know

71:12

there's different screening uh screening

71:14

guidance that's made usually start you

71:15

know in men in their 50s or so um and

71:17

Screen every year or two till a man

71:19

turns 70 you know some of the guidance

71:21

or some of the screening patterns will

71:23

vary based on family history which is a

71:24

very strong predictor of cancer risk is

71:28

there anything I can do or is there any

71:29

research that gives me advice on how to

71:33

treat my body in such a way where I

71:34

reduce my risk of prostate cancer you

71:37

know we talked about some of these you

71:38

know risks for erectile dysfunction

71:41

right like obesity diabetes I think

71:43

those same things can also play a risk

71:45

um in so a lot of these prostate

71:48

conditions too so good diet exercise

71:50

maintaining good body weight I think all

71:52

those are important avoiding drinking

71:54

water before bed

71:55

well that'll help with you know

71:57

sometimes waking up at night so for some

71:59

men that are most bothered by you know

72:01

so-called noctua or waking up at night

72:03

to urinate I think you know trying to

72:04

dehydrate yourself you know saying I'm

72:06

not going to drink any fluid after 7

72:08

o'clock at night or six o'clock at night

72:10

so that you're more likely to get you

72:12

know a full night's sleep you know

72:13

waking up once at night is not that

72:15

unusual um but if it becomes a little

72:17

bit more frequent you know that's one

72:18

strategy that some men use okay so

72:20

reducing my water consumption at night

72:22

time isn't going to reduce my chance of

72:24

having prostate cancer right okay fine

72:26

what about spicy foods so I think in a a

72:29

similar way that can also affect um some

72:31

of the symptoms it shouldn't affect your

72:32

prostate symptom thing M ah okay is

72:35

there any is there any studies that show

72:37

ways that we can reduce our prostate

72:40

risk that aren't just the sort of health

72:42

and what sort of Lifestyle related

72:44

things is there anything linked to I

72:46

don't know other parts of our lifestyle

72:48

like our use of technology or alcohol

72:50

consumption or anything at all not to my

72:52

knowledge I think that you know Asian

72:54

ore uh

72:55

the defoliant that was used during

72:57

Vietnam war that was found to be a risk

72:59

factor for prostate cancer so um I don't

73:03

know why you would but try and try and

73:04

avoid Ancient Orange um but otherwise

73:07

there are not a lot of modifiable risk

73:08

factors other than the ones that we

73:09

talked about I think that you know

73:11

cancer risk goes up with obesity you

73:12

know thought to be due to different

73:14

things but maybe inflammation and things

73:15

like that so I think kind of living a

73:17

healthy life I think hopefully will keep

73:19

you on a healthy trajectory I'm the

73:20

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73:46

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73:49

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73:50

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73:52

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73:54

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74:19

doac what is the what are the most

74:21

important things that we haven't talked

74:23

about that patients come into your

74:25

Clinic can speak to you about as it

74:27

relates to reproductive Health you know

74:30

hormones everything in between well

74:32

another condition that I see men for a

74:34

lot is something called ponis disease

74:36

which is a curvature of the penis so um

74:39

you know the way erections worth work is

74:40

everything swells you know there's sort

74:42

of these kind of tough tissue layers in

74:44

the penis that trap blood inside and

74:46

sometimes Scar Tissue can form on those

74:48

layers um for different reasons it's

74:50

thought maybe microt trauma some men do

74:52

remember sort of a traumatic sexual

74:53

episode that leads to an injury and scar

74:56

formation and you can imagine if there's

74:58

scar tissue in there everything will not

75:00

um you know kind of expand in a uniform

75:03

fashion so you can get a curvature

75:04

deviation so some of these men have you

75:07

know 90 degree curves to their penis um

75:09

and so you know whether it goes up or

75:12

down it makes can make sex pretty

75:13

challenging um and so that's another

75:15

condition we see I think it's important

75:18

for men to know I think again like it's

75:19

just similar to erectile dysfunction I

75:21

think you know men are sometimes you

75:23

know a little bit reticent to talk about

75:24

some of these conditions but it's fairly

75:26

common probably 5 to 10% of men are

75:28

affected and there are effective

75:29

treatments for this as well so I think

75:31

just as sort of a public service

75:33

announcement um if men are suffering

75:35

from this again talk to your doctor

75:36

because there are treatments that we can

75:38

we can offer okay so let's conclude then

75:41

if I want to make sure that my sperm

75:43

count remains very very high um so I can

75:46

have those four kids and I want to make

75:47

sure my testosterone levels remain at a

75:50

healthy sort of balance let's say is it

75:52

sort of 4 500 is G milligrams is it yeah

75:57

nanograms per deciliter okay nanograms

75:59

per deciliter want to keep it in that

76:00

sort of healthy range and I want to have

76:02

Rock our directions okay so that I can

76:05

have the four kids that I mentioned mhm

76:07

what is the the advice that you would

76:09

give that is broadly applicable to

76:12

everybody without you having to run my

76:14

my blood tests and all those things and

76:15

this is really a conclusive point the

76:17

first one that I've heard is about sort

76:19

of lifestyle and dietary choices is

76:21

there anything that I definitely

76:22

shouldn't be eating if I'm trying to to

76:25

become optimal in these three areas

76:27

again people have looked at sort of

76:28

different diets which can affect health

76:30

and reproductive Health you know more

76:32

specifically so I think generally

76:34

healthy foods are a good idea you know

76:35

whole grains fruits vegetables you know

76:38

usually the control group for all these

76:39

is like a western diet you know like you

76:41

know processed foods fast food things

76:44

like that foods that have a lot of fat

76:46

high calorie those you and you know some

76:48

of them also the packaging has you know

76:50

some of these same kind of chemicals

76:51

that we talked about earlier so I think

76:53

trying to avoid some of those I think is

76:54

a good idea yeah sugar um Sugar's okay

76:58

okay um unless again sort of high

77:00

calorie foods or things to to try and

77:02

avoid um if you have any medical

77:05

conditions you know I think that trying

77:06

to get those treated you know sometimes

77:08

men do worry that you know if you're

77:09

taking a pill for something it may

77:11

affect your fertility um but you know I

77:14

think just generally being healthy

77:15

anything that's good for your heart is

77:16

going to be good for fertility so I

77:18

think it's a good idea to get that you

77:19

know treated there is a study um out of

77:22

Japan that I always quote about this so

77:24

this was study that looked at all

77:25

patients that came in with male

77:27

infertility um and tried to figure out

77:29

who they helped right and so they wanted

77:30

to see if they could predict who was

77:32

likely to benefit from a Urologic

77:33

concultation and who was not and so they

77:36

looked at you know Baseline sperm count

77:37

that wasn't predictive of who was going

77:39

to benefit Baseline testosterone level

77:40

wasn't age wasn't some men had this

77:42

condition called a verical which has

77:44

dilated veins in the scrotum so about

77:46

15% of all men have them um infertile

77:49

men maybe about 40% have them so you

77:51

know the testicles are outside the body

77:53

like we talked about and having larger

77:54

veins impairs normal temperature

77:56

regulation um and so if you fix those it

77:59

turns out most of those men are going to

78:00

improve their sperm count um but the

78:02

other really interesting finding is that

78:04

they also found that men that had a

78:06

comorbidity treated had improvements so

78:10

the data they provided as men that had

78:11

high blood pressure if they got that

78:13

under control their sperm counts went up

78:15

about

78:16

25% so you know a lot of times you know

78:19

the first time men see the doctor men

78:20

don't go to the doctor a lot right

78:22

unless there's a problem right unless

78:23

they're in pain or some other you know

78:25

condition um so sometimes my patients

78:28

the first time I've ever seen anybody is

78:30

they seeing me to try and have a baby um

78:32

and so it's an opportunity to you know

78:34

make them take a little bit more

78:35

ownership of their health you know if

78:37

they've never had a blood pressure check

78:38

check that blood sugar cholesterol all

78:40

those things are you know ways to

78:42

improve their health or opportunities to

78:43

improve reproductive Health but you know

78:44

overall health as well so I think that's

78:46

another thing to be kind of mindful of

78:48

what about depression then our mental

78:51

health and the role that that will have

78:52

on our fertility are erectile

78:56

performance and all of those things is

78:58

there correlation there there's strong

78:59

correlation yeah so I think we do see a

79:01

strong correlation between erectile

79:02

dysfunction and depression you know if

79:04

you look at men with erectile

79:06

dysfunction I think up to 20% it you

79:08

know may have some form of depression um

79:11

and we sometimes worry that some of the

79:13

treatments can also you know exacerbate

79:15

sexual dysfunction but I think trying to

79:17

get men on a better path is important I

79:19

think it's also important to work you

79:20

again with a therapist as well you know

79:23

so that you kind of attacking these

79:24

things from multiple you know multiple

79:25

angles you know generally most of these

79:27

medicines you know probably have not

79:29

been tested you know in terms of

79:30

reproductive Health um there's some

79:32

studies that say that some of these may

79:35

affect seman quality but I think those

79:37

studies are limited so I think you know

79:39

generally if men are on these medicines

79:40

we're not sure and I think it's helping

79:42

them um you know we try and sort of you

79:45

know carry on and persevere because I do

79:47

want them to get the benefit of some of

79:48

these therapies what about childhood

79:50

trauma and the role that plays you must

79:52

see that show up in your practice this

79:55

yeah I mean I think it certainly can

79:57

affect Sexual Health you know pretty

79:58

profoundly I think you know when you do

80:01

suspect you know kind of this sort of

80:02

psychogenic component I think you know

80:04

we do try and be again like talked about

80:06

very optimistic about options that are

80:08

available um but working with the

80:10

therapist working with a sex therapist

80:12

to come up with sort of a good sort of

80:13

strategy and plan to kind of get um you

80:16

know men through you know some of these

80:18

issues um so they can have you know a

80:20

fulfilling sex life anything else that I

80:22

need to do to improve these things

80:24

Topline things so lifestyle TR you know

80:27

we've talked about food exercise we've

80:30

talked about as well as a way to improve

80:32

at least our testosterone levels yeah

80:34

sleep I guess might be a important

80:37

sleep's important too sleep's

80:38

interesting because it's um it's what's

80:39

called a U-shaped Association so it's

80:41

it's possible to get too much sleep so

80:45

you know you probably want sort of an

80:46

ideal amount probably seven to nine

80:48

hours is usually that's been associated

80:49

with better seamen quality for men that

80:51

get less seamen quality tends to be a

80:53

little lower for men that get too much

80:55

sleep uh you know again men that have

80:57

you know are able to sleep 12 13 14

80:59

hours a day there may be other things

81:01

going on there maybe there's some

81:02

underlying depression or something those

81:04

men tend to have lower semen quality but

81:06

you know I think sleep I think is

81:07

certainly important there's also been

81:09

studies looking at weight loss as well

81:11

you know I think it's obviously easy to

81:12

say lose weight um but it's not always a

81:16

straightforward to do um but there is

81:18

you know a nice study that came out a

81:20

few years ago where men were randomized

81:22

to you know weight loss program on a

81:24

very low calorie diet 800 calories a day

81:27

um for a few weeks and then they lost

81:30

you know weight and then they follow

81:32

them for the rest of the year um and so

81:34

this is important because men that were

81:36

able to keep weight off were able to

81:38

maintain the benefits of their sperm

81:40

count versus men that were you know kind

81:43

of fell off the exercise routine they

81:44

ended up gaining back you know their

81:46

weight and then their sperm counts

81:47

declined again uh one of these arms

81:49

actually also had one of these you know

81:51

hot glp1 analoges as well and so even

81:54

men that were on those that kind of help

81:55

them keep their weight loss were also

81:57

able to maintain sperm count so patients

81:59

do ask about that a lot you know I was

82:01

just going to ask about obviously as

82:02

zexs exploded and there's many other

82:04

forms of this sort of

82:05

glp1 um sort of fat loss injections I

82:08

was wondering if that had any

82:09

consequences on fertility so again

82:12

there's only one study that that did

82:13

study it and it did seem to show benefit

82:15

so it doesn't cause any harm as long as

82:17

you maintain weight loss with it you

82:19

know you do seem to see Improvement you

82:21

know in contrast um you know some men

82:23

also ask about like bariatric surgery

82:25

which you know again may be declining a

82:26

little now with these you know very

82:28

effective medications but interestingly

82:31

for bariatric surger like by like

82:34

gastric bypass I don't know if this is

82:36

popular in Europe or the United Kingdom

82:38

but for some obese individuals um there

82:41

are surgeries that can be done to help

82:42

sort of reroute intestinal absorption um

82:45

so you can lose weight with that there's

82:47

also something I thought you meant the

82:48

gastric band thing there's gastric bands

82:50

too yeah so there different ways that

82:51

it's been done and so with all those um

82:54

actually uh tends to decrease sperm sort

82:57

of right paradoxically so you would

83:00

think that if you lost weight your sperm

83:02

counts would improve but it turns out

83:04

with these surgeries sperm counts

83:06

actually declined some of them some

83:08

actually men went from a reasonable

83:10

sperm count to zero so the thought was

83:12

that you know it's the trauma trauma of

83:14

a surgery potentially you know um there

83:16

are you know some vitamins minerals are

83:18

important too so um you know without

83:21

that normal absorption that occurs in

83:23

the intestines that could also lead to

83:25

infertility you know that was sort of a

83:28

concern and we were wondering if that

83:30

same thing would happen with you know

83:31

these newer medications um but it

83:33

doesn't seem like it so again the glp1

83:35

analog seem like they safe safe form of

83:38

weight loss at least when we're looking

83:39

at semen quality as an outcome what

83:41

about supplementation is there any

83:43

supplements one might recommend I guess

83:46

it's difficult for you to recommend

83:47

supplements but are there any sort of

83:50

vitamins or minerals that are typically

83:51

deficient in people that have have

83:53

infertility issues so I think there is

83:55

some data that antioxidants can improve

83:57

fertility so it's sort of a very broad

83:59

group um of things that have been tested

84:02

berries and stuff is that like yeah dark

84:04

berries yeah those certainly can have a

84:05

lot um but you know I usually tell you

84:08

know patients to take a multivitamin

84:09

they do make special male fertility

84:11

Blends like if you were to look it up on

84:13

the internet or Amazon or other

84:14

platforms there are special fertility

84:16

Blends that have kind of some of them

84:18

have you know looked at the data and try

84:20

and pick out you know specific

84:22

supplements that are thought to be more

84:23

beneficial coenzyme Q um is a powerful

84:25

antioxidant that has shown some benefit

84:27

for fertility so I think that's

84:29

something else that you try and Empower

84:31

patients and they can do that too and

84:32

that that can help protein does that

84:34

play a role in fertility or testosterone

84:37

I think you know again sort of part of a

84:38

balanced meal part of a balanced sort of

84:40

diet I think it's important what's your

84:42

mission from here on what are you going

84:43

to do for the next 10 years if you had

84:45

to ha it a guess what's are you going to

84:46

do is it more of the same or are you

84:47

going to are you interested in changing

84:50

um focus at all slightly or are you

84:53

going to just continue to do research on

84:54

these subjects what's your big sort of

84:56

decade Mission yeah I mean this really

84:58

gets me up in the morning and this is

84:59

the stuff that I like to do like late at

85:01

night as well I mean I really passionate

85:02

about this trying to understand you know

85:04

why we see this link between fertility

85:06

and health why sperm couns are declining

85:08

because I think the more we understand

85:09

about it we can you know hopefully

85:11

mitigate some of these risks um also

85:14

like to hopefully you know through you

85:16

know information channels and platforms

85:18

like this you know hopefully engage more

85:20

of the community to try and come up with

85:22

some therapies you know for male

85:24

fertility I think you know we talked

85:26

about some of the things that can be

85:27

done but there's no you know in in the

85:29

United States there's the Food and Drug

85:31

Administration that sort of oversees all

85:33

you know Therapeutics and there's no FD

85:35

approved therapy for male fertility

85:37

which is really a shame especially

85:38

because you know again we have this data

85:40

that it's becoming more prevalent

85:41

existential right as a species so it'd

85:44

be nice if there was some so try and get

85:46

more engagement from the scientific

85:47

Community from the pharmaceutical

85:49

Community um to try and you know see

85:51

that opportunity um because I think

85:53

that'll be very important for for you

85:54

know for our Fields but again you know I

85:56

think like you said sort of more of the

85:58

same in some ways but I think trying to

86:00

understand some of these questions in a

86:01

lot more detail so that we can you know

86:03

really help these men is there of all

86:05

the subjects we've discussed today is

86:06

there a particular part of it that

86:08

concerns you the

86:10

most well I think you know when we're

86:12

talking about sperm counts declining I

86:14

do worry that that is a barometer of

86:16

health and so it may be that you know in

86:18

addition to men's reproductive Health

86:20

just our overall health is declining you

86:22

know when we look at sort of the health

86:24

of fathers over time we've seen you know

86:26

fathers are getting a little older you

86:28

know we talked about that but you know

86:29

with that comes more comorbidities right

86:32

higher rates of hypertension hyper

86:33

lipidemia you know other things and that

86:37

sometimes can have sort of

86:38

transgenerational impacts so like a

86:40

father that has high blood pressure or

86:42

you know is obese that child is you know

86:45

a slightly higher risk of having some

86:47

other issues later on so trying to

86:49

understand that again if there's maybe

86:50

opportunities to try and figure out what

86:53

in that sperm is a little different

86:54

maybe we can turn that switch off to try

86:56

and you know prevent that I think those

86:58

are all things I don't want to be

86:59

alarmist about this these risks are all

87:01

very very low um but I think there's a

87:03

lot of opportunities um you know I think

87:05

one of the reasons I got into it I think

87:07

is because male reproductive Health was

87:08

really wide open so I think there's

87:10

still a lot of opportunities to try and

87:12

improve

87:13

it what would you say to a man that's

87:16

listening to this that's struggling with

87:18

any of the things we've discussed what

87:20

is what is your your closing message for

87:23

them well I think I would just try and

87:25

be optimistic and hopeful I think

87:26

there's a lot that we can do I think

87:28

that you know it takes a lot of Bravery

87:29

you know to go in and see doctors about

87:31

some of this thing and some of these you

87:33

know different these different issues

87:34

but you know it's what we're used to

87:36

dealing with and I think there's uh you

87:38

know plenty of options that are

87:39

available so I would just encourage them

87:41

to you know talk to friends but you know

87:43

men talk to their primary care doctor

87:45

talk to their urologist come see

87:47

urologist you have a very broad platform

87:49

so I think if there's couple struggling

87:50

they've only seen gynecologists I would

87:52

encourage them to maybe see you a male

87:54

reproductive specialist as well to try

87:56

and get some other perspectives we have

87:58

a closing tradition on this podcast

87:59

where the last guest leaves a question

88:00

for the next not knowing who they're

88:02

leaving it for the question that's been

88:04

left for you is a tricky one it is

88:06

what's one thing you would do to change

88:10

the

88:11

world I guess one thing that I would do

88:13

to change the world I guess is certainly

88:15

um appropo of our conversation was that

88:19

I would make um try and make policy that

88:23

all governments would pay for

88:25

infertility services so that this is a

88:28

universal benefit for all of humanity I

88:30

think that would certainly help open up

88:32

the doors for a lot of people that don't

88:35

have resources for it kind of hesitant

88:37

to use it um and hopefully that would

88:39

again solves some of the issues that we

88:41

talked about from a demographic

88:42

standpoint what would that do for

88:44

Humanity we' be having more kids I guess

88:47

we'd be happier in in our relationships

88:50

potentially I mean yeah I think it could

88:52

do all that I think that you know I

88:54

guess from from a father standpoint

88:57

having a child again increases longevity

89:00

um decreases cardiovascular risk um

89:03

increasing from a sort of societal

89:05

perspective having you know um getting

89:08

getting to that replacement level sort

89:09

of maintain population I think that's

89:11

again existential for a society um

89:14

increase the tax base and all the other

89:16

things that are associated with that and

89:17

the workforce it's very difficult in

89:20

politics now certainly in United States

89:22

um there's a lot of you know ISS isues

89:24

that are going on but you know making

89:26

policy that really affects everyone I

89:28

think would be you know very profound

89:29

and I think there's be a lot of um

89:32

benefit to

89:34

that Dr Michael Eisenberg thank you so

89:37

much for your time and thank you for the

89:38

work that you're doing because you know

89:40

you're uh you're helping to ultimately

89:43

to create families and to also alleviate

89:45

a lot of the stress and anxiety and

89:47

worry and concern um people have about

89:51

their reproductive health and I think

89:53

it's an incredible service to humanity

89:55

to be doing that and especially at the

89:56

time when we're in where it feels like

89:58

it's more needed than ever before and

89:59

frankly the direction of travel isn't

90:01

fantastic um as it relates to some of

90:03

these big issues like you know

90:05

testosterone and fertility and um but

90:08

it's it's really important for you

90:09

people like you that have the

90:10

information that are doing the re

90:12

research to not just keep it in the lab

90:16

and not just keep it on Pub Med where

90:17

it's very hard for people like me to

90:19

access it because we can't bloody read

90:20

PubMed um so thank you for for for

90:23

making the decision which you don't have

90:24

to do to come out and speak on these

90:25

subjects in a way that's really

90:26

accessible um and inspiring and

90:29

empowering for people because I think

90:30

that's going to do a tremendous world of

90:31

good so thank you thank you my

90:34

pleasure how many of you started

90:36

thinking about your long-term Health

90:38

when you hit 30 for me this was a wakeup

90:41

moment of me thinking to myself okay I

90:43

probably need to start paying a little

90:44

bit more attention now I already felt a

90:46

change in myself when I hit 30 with

90:48

things like my metabolism my energy

90:50

levels so this year is no different Zoe

90:54

which is a company I've invested in but

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also a company that are a sponsor of

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91:04

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91:37

[Music]

91:54

m

Interactive Summary

This episode features Dr. Michael Eisenberg, an expert in male sexual health and fertility, discussing the current trends and challenges in men's reproductive health. The conversation highlights the decline in testosterone and sperm counts, the impact of environmental and lifestyle factors such as plastic exposure, heat, and sedentary behavior, and the critical importance of overall health in improving fertility outcomes. Dr. Eisenberg emphasizes that fertility is a team sport and debunks the myth that reproductive issues are exclusively female-related.

Suggested questions

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