I'll give another sort of medical one

that I think is is interesting and I've

been texting and interacting with Matt

Walker a lot on this. Matt is a

scientist. He wrote a book Why We Sleep

and is about as credible as you can be

within the world of sleep science.

>> He's the best and he's a great human.

Fantastic human.

>> He's a great guy. Great guy. has the

most pleasing duet tones with that

British accent and

kind lil in the voice. The plus 10 IQ

accent basically plus 10 or 20 IQ points

with the accent. But his podcast is also

excellent and we can link to it in the

show notes. But he did an episode on a

class of sleep medication called Doras

and D A stands for dual arxen receptor

antagonists. And

the reason that Dora's became very

interesting to me is that I have

Alzheimer's in my family

and it's it's left, right, and center

for me right now because I have three

relatives currently diagnosed with

Alzheimer's.

>> Holy [ __ ] And these are APOE4 negative

folks.

>> It includes APOE4 negative folks. So we

won't get too far into the genetics, but

people who should not be based on that

that particular

>> parameter should not be particularly

inclined to Alzheimer's nonetheless have

Alzheimer's. And then there are of

course people who have 34. I don't think

any of them are APOE33. I am Apo E34. So

compared to a 33 that at least as I

understand it would predispose me say

2.5 times. You and my wife and Rhonda

Patrick and a Tia 2 actually is a 34.

>> Yeah, there you go.

>> All of you guys. I'm the only one that's

not crazy. In effect, to our current

understanding,

you want to mitigate the accumulation of

two things is one is beta amalloid

plaque, another is tangles that are

created by cow proteins. And

sleep is really imperative for this.

>> Mhm. And if you have sleep issues as I

have for decades, right, the onset

insomnia, low percentage of deep sleep,

etc., you're effectively unable to

have your your garbage service within

the brain

clear out these at a rate that offsets

the accumulation. And by the way, we

don't know if these are causal, right?

There's never been any conclusion

whether these are causal. are most

likely the protective effects of

something else gone arry. Do you agree

with that?

>> I would say that based on our best

understanding, if you can mitigate the

accumulation of these things, there

seems to be a at the very least delaying

of the progression of these diseases and

there are different drugs infusions like

donanimab and so on that are kind of

predicated on that understanding of of

the mechanism. This is still early days

in the world of Alzheimer's.

>> Yeah. But it seems very defensible with

our understanding currently that the

less of this stuff you accumulate the

better off you are. Do you uh follow

Dale Bredesen's work by the way?

>> I don't. Let's come back to that. Let me

just quickly tie this up and say that an

example of Adora would be Bel Samra.

There are a handful of others but I have

taken as I believe you have well

actually no it was too strong for you. I

gave you some dude. Yeah that's right.

You gave me the bells.

>> I gave you a bunch of bells and you were

going to give me some other [ __ ] back

and you never gave me anything good.

>> Well, hold on. Hold on. That's still

pendant. But let me let me come back.

So, you gave me the bells, but I started

using it. I was going to get it on a

prescription. It's expensive as [ __ ]

>> Yeah. I paid a [ __ ] ton for it and then

I didn't use it.

>> Yeah. And I was like, "All right, I'll

take your bells." But the the Trazadone,

I got off of Trazadone and switched as a

sleep medication to, in this case,

Belsra because it was literally down the

street in an Uber at your house. Not

recommending you use your friend's

bootleg drugs, by the way. Talk to your

doctor. But we also have physicians that

are looking at all our [ __ ] so it's not

a big deal for us. I have been now on

bells for a few months as hopefully a

it's too strong to say it's a

preventative strategy but at least a

delay strategy for potentially

Alzheimer's and other associated

neurogenerative conditions. So I would

encourage people and I'll link to this

in the show notes to check out Matt

Walker's podcast on this specifically.

You know what they did with Bells Armor

where they tapped the spines of people

that took and they noticed there was

less tow proteins in the spinal fluid.

>> Yeah, they cleared a lot more. They

looked at animal models and then they

looked at humans. And in that podcast

episode also Matt discusses data related

to comparing say Bellsra or I should say

Doras to ambient right and not all sleep

medications are created equal. A lot of

sleep medications effectively sedate

you,

>> right?

>> But in the case of Doras, Orexen, as I

understand it, is a a wakefulness.

I think it's a hormone,

>> but this is effectively inhibiting

wakefulness as opposed to sedating.

[clears throat]

>> Mhm.

>> And by using that particular approach,

you're able to create more naturalistic

sleep. So it's preserving sleep

architecture increasing certain things

like RM sleep in any case it's very

interesting because as it stands look

sure like exercise for natural release

of cloth [snorts]

watch your diet blah blah blah there's

there are a handful of things here sleep

super critically important

if we're talking about again staving off

hopefully neurodeenerative disease but

there really just aren't that many tools

in the toolkit so to to come across some

of this data via Matt Walker was very

eye opening to me.

>> That's awesome. So, that's also

something that I'm looking at really

closely.

>> I will say the scariest test I have done

in my life was about 3 months ago. I

went and had my blood work done and had

the the towel the full on like you can

check your blood now to see if you are

producing or we're always producing it

but if you are out of bounds meaning

you're above the norm in your production

of these types of proteins and if you

are it's like you know 99% chance you're

on the path to some form of dementia

right

>> and did you do that test

>> I have just done a whole battery of

different tests

>> did you do the ptow one know.

>> Yeah, I'm going to have all that stuff.

>> It's scary, dude. When you come hang

with me, we'll have a drink or

something.

>> I'm looking at all my results in

probably two or 3 weeks cuz I have a few

online batteries that I'm going to do

assessments.

>> It is absolutely terrifying because the

doctor was like, "Hey, do you want to do

this? I have this available." And I was

like, "Sure, go ahead." And then like 3

days afterwards, I'm like, "I should

look up what that test is all about."

And I did. There's like three of them

now that can detect these various

proteins that are essentially if you

have elevated levels like you're on

you're marching orders or you're heading

towards some type of dementia. And I

realized that and I was like wow if this

comes back positive like I need to be

like this is an emergency situation

where highintensity interval training

every single morning for an hour like

there's a lot of things you have to get

into and it's a very frightening thing.

It's a very frightening thing. Yeah, it

can be super frightening. And you know,

there there's certain other things that

I think are are just

holistically good for my particular

goals, cognitive, psychological,

physical, like the ketogenic diet,

right? I recently did a podcast with

David Bazooki, the co-founder and CEO of

Roblox. He and his wife have a

foundation that is one of the large it

is the largest funer of science related

to metabolic therapies with a particular

focus on on ketogenic therapy. So I will

be doing all of December in ketosis as

an example.

>> Oh that's amazing. Just to keep that

metabolic machinery humming because I I

do think it's plausible that it could

help long term with a lot of the stuff

we're talking about. Tim, real quick

just to put a bow on this. Dale Dale.

Yeah. So, the reason I like Dale Dale's

a scientist that studies all forms of

dementia. He has a book called The End

of Alzheimer's. You've probably heard of

that book. It's it's pretty popular.

>> I've come across his name. He's a little

bit different than most of the

scientists out there where he believes

that, you know, Alzheimer's and these

other dementias. They're not just a kind

of one-sizefits-all. One thing went

wrong, but it can be a suite of

different things that go wrong that lead

you down this path. And so, it's

metabolic disorder. It's potential

toxins. It's like, you know, I think

he's like the four major contributors to

different various forms of dementia. And

he's developed this protocol that can

stabilize and even reverse a lot of this

early cognitive decline if you catch it

early enough. It's a little bit of like

throwing the whole kitchen sink at it

because it's everything. And he's not

quite sure exactly what is doing the fix

here, but it's fascinating the research

that he's done. I highly recommend two

things that stood out to me that he

recommends is one getting this this PA

test done on the blood front and then

also recommends the ketogenic diet. He

thinks ketogenic diet [clears throat] is

huge for people and he's seen that alone

stabilize people from mental decline and

not that they're not eventually going to

get it. Yeah. But the the point is like

do you want to go into full decline

within 5 years or do you want it to be

15 years, right? And so that's kind of

what he's his lab's focused on.

>> Cool. Yeah, I'll check them out. I mean,

I've seen,

not that this is a necessarily

sustainable or scalable approach, but

with some of my relatives with

Alzheimer's where it's pretty progressed

and they tend to give, you know,

one-word answers or get confused and

give the wrong answer to questions,

giving them, say, 35 milliliters of

exogenous ketones. So they're not in

ketosis,

>> they're following the terrible diet

they've always followed. But give them

35 milliliters of kind of high octane

exogenous [snorts] ketones before going

for a walk and within 30 minutes they're

speaking in full sentences.

>> It's wild. You see some really wild

temporary but nonetheless very

interesting transformations which comes

back to what you said about metabolic

syndrome. And there are good reasons why

some folks refer to Alzheimer's as type

3 diabetes.

>> 100%. And that's what he says in his

book. He's like that is definitely a

contributor. Yep.

>> Excess glucose levels and all the

downstream inflammation effects that

come from that. It's just bad bad news

bears as you like to say. That's

embarrass [laughter]

news bears.