SpaceX-Cursor Deal, SaaS Debt Bomb, New Apple CEO, SPLC Indictment, Colon Cancer Spike
2790 segments
Jason, you are the unique person that is
at the intersection of both the
and the SPLC files. Do you have
[laughter] a comment?
>> Do you have a comment, Jason?
>> in the SPLC files. I
>> Yes, you are. You're adjacent to the
vice president. You're SPLC adjacent and
you're
What does that mean? In the Venn diagram
>> Thank you, though, for putting me in the
crosshairs of all the losers.
>> He's got a I got a really good way to
select. I mean,
>> There's a reason why I'm carrying this,
guys. It's because the people
>> What the [ __ ] is going [laughter] on?
>> THERE'S A REASON WHY I CARRY a stiletto
and a P35.
>> What the [ __ ] are you doing? [laughter]
>> There's a reason. If you want to jump
the fence, feel free.
>> [laughter]
>> J CAL IS READY.
>> YOU LET YOUR WINNERS RIDE. [music]
>> RAIN MAN David Sacks
>> And I said, "We open-sourced it to the
fans and they've [music] just gone crazy
with it."
>> All right, everybody, welcome back to
the greatest podcast in the universe,
episode 270 of the All-In podcast, your
podcast for your favorite podcast. With
me again, your sultan of science, David
Friedberg, the dick
tater, Chamath Palihapitiya, and yeah,
the Rain Man is back. Yeah, it's
definitely David David Sacks. He's
definitely in DC with a with POTUS,
yeah. POTUS lets him drive in the
driveway. Uh Sacks, what's going on? You
you pushed back, you big-shotted the
entire crew, and pushed the show back an
hour.
>> Simple text. He's like, "With POTUS."
>> Start unbelievable.
>> Start later.
>> Okay, we'll just wait. Okay, Daddy. Look
at him. All right. All right, big shot.
What's going on?
>> No, look. I was in DC today and I was at
the White House and
I just asked if the president had time
and he made time. And we had we did have
a little meeting and so we did push back
the pod for that. One thing I just want
to say is just what a pleasure he is to
deal with. You know, when I read in the
media, they're always describing him in
a certain way that you know, he's
yelling at people or he's moody or or
something like that and that's never
ever been my experience with him. He's
always pleasant to be with. He's always
genial.
>> Super charming.
>> questions. He's interested in the
subject matter.
It's just a completely different
portrayal. I don't get where the media
is coming from at all on this.
>> He's charming AF.
>> Totally. Totally.
>> He's charming.
>> maybe if you double-crossed him, maybe,
I don't know, but I've just never seen
any evidence of of how they describe him
at all. And I think on our issues of AI,
I think we're really lucky that he's the
president who's in the White House when
this AI revolution is happening.
>> I mean, doing alt history, Sachs, what
would happen if Kamala ding-dong was in
right now and we'd have like no data
centers?
>> We'd have no data centers and they'd be
using AI to censor us and they'd be
promoting DEI values through AI. That
was in the Biden executive order.
President Trump just wants the country
to win and be successful and he doesn't
have these like doomer neuroses about
it. That's not to say we don't support
any regulation at all, but we should
have specific solutions for specific
problems as opposed to being cowering in
fear over this and just trying to halt
all progress. And I think a really good
example of that was his idea around data
centers where he said over a year ago
before data centers even became a hot
political topic, that we should let our
AI companies stand up their own power
generation behind the meter. And that's
a much better approach than the Bernie
Sanders approach of just shutting
everything down. So, I don't know. I
think we're like very fortunate that
he's the president during this critical
time in development of this technology.
And like I said, he's always been
interested in it. He talks a lot of
business leaders. I'm always actually
very impressed with what he already
knows. He listens to like all the the
guys in the industry and he synthesizes
what he hears. I think he's very good at
that.
>> He was talking about the Anthropic guys,
and he was like, "These are brilliant
guys." And he was like, "Giving the
flowers to them and how genius they
were, and that they were working on a
deal." Any insights there about the
relationship between the White House and
Anthropic?
>> I thought what he said was very balanced
and accurate. Like you said, he said
that they were very smart guys. They do
have a great product. I've certainly
acknowledged that. He also said that
they were very left-wing, but that was
something we could work through.
>> Hm.
>> Didn't have to [clears throat] be a deal
killer. He said they tried to tell the
Pentagon what to do, which the Pentagon
didn't like. But in any event, I mean,
look, he wants American companies to be
successful, and he he I think genuinely
really does like high-IQ people. I mean,
he says it all the time, and people
think he's joking, but I actually think
it's like one of his core convictions is
he just really likes smart people. He
likes being around smart people.
>> Loyal people, smart people, people who
are good on camera seem to be the three
circles. And hey, Sachs, you fall into
two of the three. [laughter]
Uh all right.
>> I thought the audience would bring it
that out.
>> Uh topic one,
SpaceX has signed a huge deal with
Cursor.
You know Cursor, that's the AI coding
startup. Really, they they they defined
the category. XAI and Cursor are
building and collaborating on a new AI
coding model that would, quote, be the
world's best coding and knowledge work
AI. Here's the deal as it's been
explained. SpaceX will either buy Cursor
by the end of 2026 for $16 billion.
That's $10 billion more than they were
rumored to be raising at, or they will
pay Cursor $10 billion for their
collaboration together. Bloomberg says
you can think of that $10 billion
essentially as a breakup fee. So, I
think it's fait accompli that this deal
is going to get done.
Cursor's run rate, $2 billion at the end
of February. This is a money-printing
machine. They expect to end 2026 with a
$6 billion dollar rate. They're going to
triple it. SpaceX projected revenue
between 22 and 24 billion in 2026. So
this is quite accretive to the revenue
story at SpaceX at the IPO of SpaceX,
which is now targeting a valuation of 2
trillion.
Which would be trading at roughly 80
times top line revenue, which is a, you
know, people would say it's a high
valuation, but also commensurate with
the opportunity. Cursor's valuation
would be 30 X. So this is a good deal, I
think, for everybody at the end of the
day. Cursor started, I think, built off
of Anthropic's LLM. You could use any
LLM previously on it, but in March
Cursor released the second version of
their proprietary model, Composer 2. And
uh here it is. It's It's ranked pretty
high right now. It's between uh GPT-4
5.4 and Opus 4.6, as you can see on the
screen.
The key part of the story here
is that Elon has 550,000
GPUs in Colossus. He's scaling up to 1
million, and then of course he's going
to bring it to space. So if you believe
that infrastructure matters, and it's
pretty clear it does, this is incredible
for Cursor, who has been compute
constrained. So this is peanut butter
and chocolate. If you put these two
together, I predict that this is going
to move
Space X X XAI and Cursor to the front of
the coding leaderboard within 12 months.
That's my prediction, Chamath.
>> Shareholder in SpaceX via the
acquisition of the Starlink company that
you were a backer of. What are your
thoughts?
>> The acquisition was essentially
negotiated, and the way that it's
structured is so that the S-1 doesn't go
stale. So I think the way that it was
announced has more to do with the fact
that they don't want to slow down and
have to rewrite parts of the S-1, have
to redo the disclosures, um
have to redo the risks. and so I think
what you're going to see is that this
will get done. In fact, the deal is
effectively done.
But what's so smart is that where is
SpaceX today? Let's call it
a trillion.
Where could it be?
Just for the purpose of this argument,
let's say 2 trillion. So when the deal
gets done on a stock for stock basis,
it's going to be if again, if it's 60
billion in tomorrow dollars,
effectively Elon's gotten a 50%
discount. And what has he bought? He can
issue a 60 billion dollars of stock at a
2 trillion dollar valuation and get a
model and a service that I think is
extremely compelling in coding, which is
where we know all of the immediate and
short-term revenue gains are. It's also
patterns that are hard-fought and are
really valuable in reinforcement
learning. He gets all of that. And then
he gets a very cracked team, which, you
know, we've known for a while that the
cursor team is absolutely excellent. If
you look at the Grok usage, it shows
why he had this excess capacity. There
was a moment where Grok had a very steep
and very aggressive discount on their
output tokens.
And in that moment, there was just a lot
of experimentation and usage. And over
time, that sort of
went away.
So there was a lot of capacity and
relatively low utilization, I think,
inside of Colossus that he was able to
turn around, jujitsu move the whole
thing, and basically acquire the most
interesting and valuable third-party
wrapper service in AI right now. So, and
the fact is that they got it
effectively, I think, at this price for
30 billion.
So I think it was a really good deal,
really smart deal.
>> Sacks, your thoughts if you want to
unpack it a bit. Under the framing, I
think it's be interesting for you.
If we were sitting here 3 years ago, the
Biden administration didn't invite Elon
to
the EV summit, and the SEC, and other
organizations, Delaware, they were
explicitly involved in lawfare. They
were trying to put Elon in prison, and
here we are, the most important company
in the history
of the United States, SpaceX AI and
Tesla, now on the verge of just creating
the greatest products in the history of
humanity between SpaceX,
clusters in space, and Optimus. Your
thoughts?
>> Well, you're right. I do remember a
press conference where Biden said we got
to look at the sky. And so, on the heels
of that, the DOJ brought a a lawsuit
attacking the company for not hiring
enough asylum seekers. Remember that?
>> SpaceX, which they can't under ITAR.
>> They couldn't, exactly, under ITAR.
Anyway, that's all ancient history, so
let's let's put that behind us. Look, I
I agree with your guys' analysis on
this. I think these two companies are
are very complementary. Cursor,
obviously, is very strong in coding.
And that's what it brings to xAI. xAI
brings compute, and they bring a
foundation model. And the problem that
Cursor had is that even though coding is
kind of like the white-hot area of AI
right now,
when it got started, it was really
competing against generalists in the
form of Open AI and Anthropic. But now
those generalists have decided to
vertically integrate in this area of
coding, right? And so, Cursor's now
competing against Quad Code and Open
AI's Codex. And so, they were dependent
on foundation model companies that were
getting in the business of competing
with them, which was just not a good
place to be, right? So now, they have
this new alliance with a different
foundation model company, which also
brings the compute. Just makes a lot of
sense, and then they bring Cursor brings
to xAI
the training data,
a lot of enterprise clients, and the
experience in coding. And I think this
will accelerate xAI in this area.
>> Sacks, you think they're going to dump
Kimmy K2
.6?
Cuz I think Cursor Composer 2 uses the
Moonshot model. There's no reasonable
way that Elon's going to pay $60 billion
and not run on top of Grok. I got to
think.
>> It seems like it.
>> Yeah.
>> Likely, but I don't know.
>> I think it might be tough depending on
the the users. One of the things that
makes Cursor so good is
>> wait. Say Say more on that. What do you
mean?
>> So, I think that the different
developers
want to have choice in that sense.
There's a toggle. So, one of the things
that's really good about Cursor is
they've got this very well-built out
IDE, this application layer that puts
them probably from a UX perspective,
meaning developers are using the tool
above Codex, above Claude, above
anything else. You can use a third-party
IDE and integrate the models or
integrate whatever other third-party
service you're using. But I would
imagine that the developers are going to
want to
continue to have at least some choice on
what's actually writing the code for
them. The thing that people are waking
up to in the last 120 days
is just how much of the value of AI is
being realized by writing software. And
we've kind of got this wrapper term we
call it agents. But agents are
fundamentally just quickly spun up
applications.
But for all of them, as we're realizing
very quickly, you end up making too many
agents. They end up being super
inefficient. They need to be engineered.
And you still need to have a strong
software engineering capability and
competency to fix all the agents, to
build all the harnesses, to make
everything work well together. And
that's why having a strong developer
environment, a strong IDE, actually
solves that biggest problem. So,
eventually all the enterprises that are
getting hot and heavy on agents are
going to be like, "Whoa, wait a second.
We've actually got to fix how this is
all being done." As we saw this week in
that story with Amazon, where there's
like a million agents being spun up
inside and everything's wasting
resources, redundant data creation,
redundant data stores, redundant API
calls, et cetera. Tons of money being
wasted. So, you have to centralize
still. You have to have good software
engineering talent that's making good
infrastructure and good use of these
agents. And that ultimately will require
an integration of the AI tooling with a
standard software engineering front end,
which is the IDE that Cursor has. So, I
think that that's probably where
everyone's waking up to the fact that
having the the software engineers
may end up winning you the arms race
here. And seems pretty smart for Elon to
buy Cursor.
>> One other piece of it, you mentioned K
me uh K2.6. Yeah, I mean, so I think
that one of the things that's going to
become a priority over the next several
months is this idea of optimizing
because enterprises token bills are
going through the roof right now. I
mean,
this month over month they're spending
increasingly large amounts because their
employees are just building more and
more software, but I'm not sure that
anyone's been incentivized yet to be
efficient about it. And it really only
makes sense to go to a frontier model
for a frontier task, but more mundane
things can be done using an open source
model or less expensive model. And I
think like you're saying, whether it's
the IDE or something else, there needs
to be some sort of
middleware that determines which model
you go to and how much you're willing to
spend and what the most efficient way of
getting the tokens is going to be.
>> I am deep in playing with XAI's suite of
products and I would predict
we're going to be sitting here in 6 to
12 months and they are going to be
dramatically dramatically improved.
>> Let me just flag one other area that I
think is maybe the white-hot center
within this red-hot area of [snorts]
coding,
which is cyber.
And I think Mythos has kind of woken
everybody up to the potential of
frontier models to be a weapon that can
be used by either cyber offense or cyber
defense.
Now, the issue with Mythos is that it's
very large and expensive. It's something
like a 10 trillion parameter model. And
there's a lot of reports that Anthropic
just doesn't have enough compute to be
able to serve it. I'm not sure it was
ever built to be a commercial model, to
be honest, because I just think it's so
big and expensive, but
I think what will happen is
these companies will start training
dedicated cyber models.
They'll say Mythos comparable models,
but with a lower token cost, and
I think there's a real race on right now
to get those products to market, because
I think IT departments and CISOs are
very worried about the risk of hacks
right now, AI-powered hackers. So, this
is something I think over the next 3-6
months will be, again, this maybe the
hottest part of the market.
>> Polymarket says all of this is fake.
Complete SpaceX acquiring Cursor, 74%
chance. SpaceX IPO by the end of August,
80% chance. So, this is happening,
folks.
All right, let's keep it moving.
>> I think that deal structure is smart,
because, I mean, to Chamath's point,
yeah, it prevents the IPO process from
being disrupted. Also,
it kind of gives a huge motivation to
these Cursor guys to bust their ass and
make it work over the next, I don't
know, 6 months. Yeah, they have a $10
million break-up fee, but I'm sure they
want the deal to be successful.
>> Well, the $10 million break-up fee will
go back to SpaceX anyways, because if
they actually run the compute and
they're not owned by SpaceX, they're
going to have to pay for it. That is not
cheap.
>> I mean, we saw a bunch of these
xAI co-founders leave after the
acquisition by SpaceX. I don't know if
that was the reason why, but, you know,
all of a sudden they're sitting on
SpaceX stock, and they may have felt
like
they had it made, you know?
>> Well, it's actually
>> always a problem. It's always a problem
with with M&A.
>> This Cursor thing came about pretty
quickly, because
Okay. Let's just say friends of ours who
were supposed to wire into that round
were like, "Where's the wiring
instructions?" It all just evaporated.
Here's a tweet from Elon. We don't have
to um speculate too much. Here's Sachs.
He was very clear that uh xAI wasn't
um built right the first time around.
The quote, "XAI was not built right
first time around, so is being rebuilt
from the foundations up." Same thing
happened with Tesla, and uh that tweet
is from
about 5 weeks ago.
>> How crazy is it then when he tweets he
gets 50.8 million views?
>> It takes the four of us 7 months to get
50.8
>> our collective
>> It's unbelievable the distribution he
has.
>> Well, also, how many CEOs would just
fess up like that and say, "Yeah, that
we didn't do it right the first time and
now we're rebuilding it." I mean, most
of them are not willing to say that.
>> He's a magnet for talent. He's a magnet
for the right kind of talent, and the
SpaceX talent has his philosophy. He
inherited, I think, a lot of
you know, maybe uh people for XAI or for
Twitter that were not in his mold, and
they're clearly getting aligned. And
it's also going to make his day-to-day
life much easier when all of these
things are occurring in the same
building with the same team. The
continuity of not having to task switch
between companies is going to be great.
We talked a little bit about the
possibility of Tesla and SpaceX merging.
>> Even Walter Isaacson now is on the Tesla
SpaceX merger train.
>> Mm, there you go.
>> He just did a pod.
>> Everybody's confirmed it. It's going to
happen. We called it here first.
>> Okay, topic two. Is there a SaaS debt
bomb in private equity?
Thoma Bravo, we had Orlando Bravo at the
fourth All-In Summit last year, is
nearing a deal
to hand its company Medallia over to its
creditors. This is a SaaS
for customer experience company. TB
acquired them in 2021 for 6.4 billion
all cash
at the top of the market.
As part of the deal,
they incurred 3 billion in debt, and for
background in 2021, this company had 470
million in revenue growing 20% a year.
Earlier this month, Bloomberg reported
that TB's debt servicing costs for
Medallia were about to triple from a
hundred million a year to three hundred
million a year. Blackstone and other
firms refused to extend
a lifeline to the company to the SAS
company. So, it looks like Thoma Bravo
just handed the keys back and wiped out
5.1 billion in equity. Chamath, your
thoughts? We've been talking about the
SAS headwinds for a bit. You've been
quite vocal about it.
>> Well, first of all, I think Thoma Bravo
is an unbelievably well-run
organization. Their returns are bonkers,
and Orlando is
really, really, really good investor.
So, what do I think happened?
I suspect that they probably got enough
of their equity, if not all of their
equity.
There's probably a decent chance that
they did at least one or two dividend
recaps in the last five years.
And if I had to guess, I suspect that
they are
positive return. It may not be the
return that they would want. And so,
turning the keys over becomes easier cuz
you have to remember,
in private equity, the entire playbook
is for transformations of assets that
are at some point not working.
Right? It's very rarely that they're
buying the same kinds of businesses that
the four of us would buy, which is just
sort of this, you know, clean white
sheet de novo grow at all costs kind of
business. So, they have operating
partners and all of these other people
waiting in the wings
to un-
situations. That's the whole playbook.
Mhm. So, to turn it over, I suspect
means that there is a core rot
that people couldn't fix combined with
the fact that they have probably gotten
enough downside protection that it's not
a huge thing for them. Now,
this is an issue for the bondholders,
and then that'll maybe flow through to
the borrowing costs that Thoma Bravo has
to pay maybe for a a
deal. I don't know, but I doubt that
they would just walk away from a
business. So, I suspect they probably
got most of their money out.
>> I don't know if that's true. There was
someone that published some internal
data showing
that the sales team was like 18% of
target at Medallia.
You guys know what this company does?
Medallia?
>> Customer support is the general arena
and customer experience.
>> Customer experience management. I don't
know what I don't know what that means.
>> Yeah, they'll basically send like you go
on Caribbean cruise ships and you get a
survey afterwards and then they use that
survey data to provide management
insights and operational insights to the
leadership team and the operating team
on how to improve the quality of their
product or their service. So, it's sort
of like this feedback surveying loop.
So, if I were to tell you guys, "Hey,
you want to
build a feedback surveying loop to run
your business better, are you going to
buy SaaS today or you going to ask your
AI to spin up an agent for you to do
that?" And I think that's a big part of
what's happened is all these sorts of
companies where the alternative to
buying a SaaS product is to spin
something up internally and it's much
cheaper and easier to spin it up
internally. You get a custom workflow.
>> I agree with that. But, I'm just saying
in the last 5 years, you think they sat
on their hands and didn't take a dollar
out? They're not that dumb.
>> Maybe they took cash out, maybe they
didn't, but there was still a big debt
overhang and the debt's clearly
um gotten impaired, which means the
equity
>> The debt holders The debt holders are
clearly screwed here.
>> Yeah.
>> The question is is Thoma Bravo screwed?
And I would say, if you sat around for 5
years, they're That's not their style.
They generate too much money. They're
too good.
>> So, they may have taken cash out and
covered some of their their costs, but
the equity got fully impaired and then
the debt is clearly impaired cuz you can
see how the debt and
the uh CLOs are trading, which indicates
that this business is just not doing
well. And then someone else on Twitter
posted some internal information from
Medallia saying the sales team is just
not hitting their targets. They're like
way, way off their sales targets. Which
I think speaks to the underlying problem
here.
>> Yes.
>> Which is that all of these
>> that. Yeah, yeah, please. Yeah, so the
underlying problem is that these
businesses in the SaaS space where
you're driven by net new sales every
year, how many new customers are you
signing up and then you're trying to
manage retention and you're trying to
increase sell-through and retain
customers, they're just having a really
hard time sourcing new customers and
there's probably higher than model
attrition. That's right. And when you
have a very kind of typically
historically predictable business where
you can say, "Hey, I've got a net
revenue retention of 118%
or what have you, meaning I'm I'm
selling into my install base by 18% over
what I'm making last year and then I'm
signing up new customers,
you can lever that business, right? You
can borrow money against those cash
flows because it becomes predictable.
And what's happened in the last year in
particular is agents have become so good
and so fast and so cheap that many
enterprises can simply spin up an
alternative to a vertical SaaS solution
and that's crushing the sales team's
ability to sell in. That's who you're
competing against. Now, I want to make
one point and just link this with
something else that happened this week
and that's Kevin Warsh's hearing
for Fed Reserve chair.
Kevin Warsh went and talked a lot about
the deflationary effect of AI. And I
actually think we all talked about the
SaaS apocalypse as if it's the sort of
like isolated business phenomenon where
these SaaS companies are getting blown
up. I think another lens to look at
what's going on is the incredible
deflation of how much it costs to
successfully run a business and you
don't have to pay a premium price for
SaaS products anymore. Meaning that that
piece of the business can suddenly get
much cheaper. That AI is delivering on
its deflationary promise. I'll just say
one thing about what Warsh said. Warsh
spoke a lot about the deflationary
evolution promised by AI and that he
expects that it will drive productivity
growth like we've never seen before. But
he said, "I don't know what that's going
to do to the job market that there may
be a dislocation between that
productivity growth being realized and
how the labor markets are going to be
able to respond to those things. But
fundamentally, he's saying that we're
going to see economic deflation. The
problem with economic deflation is that
when it occurs, it means some business
is seeing their revenue go down. And if
that segment of the economy is levered,
if they have debt sitting on top of that
piece of the economy where it's supposed
to always, always, always grow, like a
SaaS company's top line is always
supposed to grow, suddenly that debt
gets impaired, and that can have an
economic ripple effect that is adverse.
But what he's pointing out is that as a
result of deflation, because it's not
coming from some cost cutting or
economic contraction, what he's saying
is that the deflationary forces
ultimately lead to economic expansion
because other parts of the economy will
now grow. So if I can suddenly cut, you
know, call it 50% of my SaaS budget, and
I can reinvest that capital in other
ways of growing my business instead of
managing my expenses, all of a sudden my
enterprise will grow, and the economy
will grow. He also said, just as an
aside, and I want to make sure I cover
this so so that we're really clear, he
said the way that we've been measuring
inflation is wrong. And that he doesn't
agree with the way the Fed has been
measuring inflation because you can do a
survey of any household and they'll tell
you, "My god, everything's so
expensive." So all of the indices and
[ __ ] that are being used to
calculate an inflation index is
completely misrepresenting what the
average American is actually feeling.
And so he wants to rethink how the Fed
is addressing inflation from an interest
rate perspective, but he does think that
the overall kind of economic picture is
one of deflationary pressure and
productivity gains coming out of AI.
>> Sacks, I'll I'll drop this off to you. I
think it's pretty clear what's happening
here is that the loss SaaS's loss is the
token dealer's gain, right? And startups
are now, and we always see that they're
the tip of the spear. They're writing
their own tools, they're making their
own dashboards. I see that every day.
And if you look at the SaaS product
index, here it is. Salesforce down 32%
uh in the past 6 months. Shout out to
Bestie Benioff, best guest we've had on
SaaS at the summit. ServiceNow down 54%,
Snowflake down 43%, Adobe down 33%, and
Figma, which had a huge IPO pop
and is now down 67%.
So, what is the role of venture capital
and then private equity in addressing
the software market? Software was eating
the world. Now tokens are eating
the SaaS business and the software
business, yeah?
>> Well, I'm of two minds about this. I'm
going to talk about the opportunity for
private equity.
Let me just say backing up that
historically we only had two good exits
for software businesses. One was IPO,
the other was M&A. And then these big
private equity shops came along and gave
us a third potential exit, which is you
would sell to them
and then they would raise the capital
based on, I don't know, 1/3 equity and
2/3 debt. So, it was debt-financed
buyouts, which is something that's been
around in let's call it the non-tech
part of the economy for a long time, but
was a relatively new entrant into the
world of technology. And the reason for
that is that if you're going to
debt-finance a purchase, you need to
have very stable cash flows
because if you miss
if your cash flows miss and you can't
pay your interest on the debt then
you're going to lose all your equity
because the debt holders will foreclose.
So, in order to do a debt financing of
any kind, you have to have very
predictable cash flows. And it was
believed for a long time that software
did have those predictable cash flows,
at least for the mature businesses, the
ones that were at the stage where they
could IPO as a potential alternative.
So, it was a very attractive thing. I
Like I said, I think it was great to
have that third option. I I'm of two
minds about where the private equity
business is today. On the one hand
the pricing now has got to be super
attractive for them. I mean, we're
seeing public SaaS companies that are
doing a billion of ARR with 20% rates,
80% gross margins,
and they're trading at three times ARR.
You can buy a dollar for 50 cents.
So is that an opportunity Sachs you
think
hit rock bottom you should do a roll up?
Well, on the one hand I do think that
the pricing has never been more
attractive if you're a private equity
shop looking at a business like that. I
mean those companies used to be valued
at 13 times ARR now it's three.
I'm talking about like a category
leader. Now the downside of that
Salesforce is off 9% today. I don't know
if you guys saw this but the market's
absolutely tanking today after the
Medallia
announcement came out. Right. Okay, so
so that would be like you know I said
I'm of two minds about it. So
I would be bullish for private equity
just based on pricing but the bearish
part is that in order for their business
model to work you have to have
predictable cash flows. You can't have a
SAS company go from I don't know 120%
net dollar retention one quarter to 80%
net dollar retention six months or a
year later because a big part of their
customer base is attrited to using
tokens, right? Or to basically creating
some bespoke software. You just said the
absolute critical thing in all of this
which is you have to have predictable
cash flows. I think what happens is when
you're a startup
you typically have to figure out how to
disruptively price to enter the market.
So you're like, okay, if I deliver $10
of value I'm going to charge a dollar
and that's that's the normal playbook
like a 10% ratio, right? Of price to
value.
The problem is when you start to stack
venture capital into it and you then you
stack growth equity into it what you're
effectively
creating in in the preference stack of
your company
is that you are creating a higher return
hurdle.
Right? You got to clear 300 million, 500
million, a billion of pref and then you
have to return 15 or 20% on top of that.
So what do people do as they raise more
money?
they increase price.
But the problem is at some point when
you increase price,
you engender a ton of competition and
you put a huge target on your back.
Private equity is the last stop
because when you they come in and they
lay in billions and billions of dollars
of not just equity, but also debt and
that has to then be completely
predictable and paid back,
their only lever is to raise price. They
can never cut price to take share. They
don't they can't underwrite that to pay
back their debt holders.
And so Sachs, part of the big problem
here and why nobody wants to touch these
companies is that they are overpriced.
Yes, they're making a billion dollars of
ARR, but the unit cost has gotten out of
control. It used to be 10% of value.
It's probably now 30% of value and
everybody's looking at their contracts
thinking, well, when it comes time to
our renewal, I'm going to just cut this
in half
or I'm going to cut this by 2/3 or I'm
going to cut this by 75%
because the value isn't there anymore.
>> Or they can threaten to and negotiate a
better deal.
>> And it becomes even worse because the
minute you make these products headless,
right? And you say, I'm just going to
communicate with these products via MCP
and with agents,
you can't charge on a per seat basis.
What do you do then?
Free book doesn't need 50 seats of
you know, work day.
He needs two seats because the agents
act as the way to write in and out of
work day. So he wants to pay for two
seats, not 50. And then if you multiply
that by a million companies,
that's what gets us to this place where
it just feels like a falling knife.
And I think it comes down to these unit
costs. The unit costs and the price to
value of these products are out of whack
with what the market needs and wants.
And until they reset that or you find
new products that can do it cheaper,
we're not going to get a cleansing and a
clearing here.
>> Yeah, I think
>> way, Salesforce today is down 9% 140
billion enterprise value on 15 billion
of free cash flow.
This thing is trading at less than 10
times free cash flow. It's unbelievable.
>> I think it might be a bargain to be
honest.
>> Yeah, it sounds like bargain hunting.
And what if Benioff, who's the king of
acquisitions, what if he just starts
>> Well, we didn't we didn't put that he's
a buying his own stock.
>> Yeah, and we didn't put this on the
docket, but did you guys see his kind of
headless product announcement?
>> Yeah.
>> Do you see this? It's it's actually very
he's very smart.
>> Yeah, I mean I think it's very smart.
>> There's ways that that business can
maneuver, right? And I think they're
pretty unique. It may be that of all the
businesses in the scape, like
that you know, the ones that have that
scale, that have that multi-product
platform, that have a lot of your data,
there's a lot of opportunity for them to
you know, maneuver their way into an
evolution of the business.
>> one and cuz like if you look at it and
you compare it for example to other
companies, I think the Workday response
was to say, you can't have an AI
interact with us without paying some
kind of like toll.
>> You're exactly right.
>> Whereas Benioff is the exact opposite,
which is he's like, okay, we're going to
go headless for the whole thing, which
is really
>> right. You're exactly right. I think
that's that's going to be the
distinction of the winners here and the
losers and are you on the wrong side of
this?
>> The problem is that we have to figure
out what is the bottom clearing price
and that has nothing to do with business
quality. And so is Salesforce a good buy
at 10 times free cash flow?
Historical artifacts would tell us a
screaming yes.
The problem is that if you cut
everybody's cash flows off at year five
or six or seven,
then all of a sudden, I think you see
the natural compression to between three
and five times free cash flow.
And that is nothing to do that's that's
crazy.
>> That has nothing to do with business
quality. That just says you you
literally mathematically take year seven
through end of the future and you
discount it to zero.
>> And having free cash flow in a war chest
gives massive optionality. We've seen
this with Salesforce, we've seen it with
Apple, we've seen it with Meta, with
Google, with Uber, just having massive
free cash flow. When you've got tens of
billions of dollars, you can put it to
work and you can weather these storms.
>> J Cal, I think another another way to
think about this is
you know, to the question about
maneuverability and who has the gumption
to make the hard choices right now.
>> Yeah.
>> Look at Benioff. He's the founder of the
company. He's run this thing since its
founding decades ago. He is willing to
bet it all. He's willing to make the
change. And it may be that the index you
buy in this era of AI transformation is
the index of founders. That the founders
who are still running their businesses
are going to be the ones who are most
likely to see
>> They can burn the boats.
>> They'll burn the boats. They'll
maneuver. They'll make the changes.
>> And all and all of the guys who have
hired managers to run the business are
going to do the things that Chamath's
talking about, which is trying to charge
fees and try to maintain the old way of
doing things as opposed to reinvent for
the new future.
>> If you look at the 10-Ks, if we could
figure out what the unit price cost and
the trend and the inflation is of a per
seat license for these products,
I will point to the ones that are going
to die first.
>> Chamath, two quick points. So
>> Yeah, wrap us up.
>> Yeah. One is, yes, I would like fully
endorse what what you said about
Benioff. He's made every previous wave
work to his benefit, whether it was
social, whether it was mobile, whether
it was big data, all that kind of stuff.
What are the odds he's going to make AI
work to his benefit? I'd say pretty
good. So, his stock might be a bargain
right now. So, that is me, point number
one. Just And I want to say just a
thing about venture debt, which is I
look, I think it's fine when private
equity guys use it cuz they know what
they're doing, but I've always hated
when founders take on venture debt. And
I know J Cal you agree with me. Part of
it is that founders forget that they
have to pay it back. They treat it like
venture capital and they forget about
that. And then they get surprised. But
the other thing I've never liked about
it is it makes you more fragile. It
basically subjects you to a bunch of
business covenants and it makes it
harder for you to do an abrupt shift in
your business because now you've got a
bank looking over your shoulder and they
want to make sure they get paid, and
they have to review your financials and
all the rest of it. And to your point,
J. Cal, the companies that have free
cash flow right now are the ones that
have the most maneuverability. I hate
taking away maneuverability from
founders, and that is what debt does
because it subjects you to a fixed
schedule of payments. And so, this is
always a thing to remember, whether
you're a business or you're an
individual.
You know, when you put on that debt, it
makes you more vulnerable to big
disruptions in the market.
>> Yeah, it just you become incredibly
brittle, and founders who are listening,
when you get that in in peak markets,
peak zero
you're going to have venture debt people
offer you tons of cash, and then the
problem David and I saw up close and
personal in many different companies
where the founders would look at it as
like, "Oh, I'm extending my runway."
Well, if you're a hot startup, there's
always more venture capital, there's
always more people who want to own
equity. The equity sale gives you
optionality, and you have more people on
your team, more people rooting for you,
and aligned with equity interest, as
opposed to now you have a debt
instrument, they have a different goal,
they have different downside they're
trying
>> No bank wants to be your last 3 to 6
months of runway.
Because that means that in a high
percentage cases, they're going to lose
their money.
>> Yeah.
>> So, they're they're built to try to
avoid that.
>> I've never seen venture debt work well
to improve the quality of the business.
Never.
Never. It doesn't only only ever seen
venture debt leave tracks that damage
companies. And if you get the venture
debt, you can never actually use it. So,
the venture debt investors that
ultimately make money, it's because they
put money in a company and the company
never actually used the money they gave
them. I hate this business. I think
venture debt's like the worst
vulture-like business in Silicon Valley.
It's terrible.
>> If you get down if if the last money in
the bank is the debt you owe to the
bank, they're going to rug you. That's
when you get rugged.
>> 100%
>> You think they can afford to lose 100%
of their money when they're getting an
8% return or something like that? No
way. That's not how it works. VCs can
afford that because we have the
opportunity for
a 10x or 100x or 1000x for that
moonshot. So, we can accept a bunch of
zeros. The bank can't accept a bunch of
zeros.
>> Well, and then when they when they do
get scared and when they do think
they're going to lose their money, wait
till you see what they extract in terms
of value, what they ask for. They will
ask they'll double the interest rate,
they'll ask for warrants. It's basically
like being in debt in prison. Chamath,
you can talk a little bit about your
experience when you were
>> [laughter]
>> in debt in prison.
It's not going to be pleasant. I've been
in debt. I mean, I've had a $420 million
credit line.
And I had a moment where it was
reflexively kind of collapsing inward
because the assets that I was using to
secure it shrank in value in a moment of
market disruption.
I was scrambling and then at the same
time
there was a risk It was the worst moment
of my professional working life. I had
like a couple hundred million dollars
sitting at Credit Suisse and they were
about to implode. And so, on a weekend,
I was trying to figure out whether my
money was still there.
I had always had this rule, don't have
debt and then I violated it to try to
run the number up.
I almost got run over. I almost lost
everything.
I will never do it again. And if I ever
do it again, if you guys ever hear me do
it again, please just come and punch me
in the face.
>> Oh, we will. We've been waiting for an
excuse.
>> Can we punch you in the face for other
things, too?
>> Buffett has this line about how smart
guys go bankrupt is they take on debt.
>> Debt equals prison, [ __ ] Keep it in
your mind, guys.
>> Unless you socialize the debt and then
everyone thinks it's okay, which is what
we do with governments and that's the
problem with governments.
>> He's going to start going off.
>> Yeah.
>> Don't push the button. All right,
listen. We got to talk about TJ.
>> just just just a quick aside on that. In
the 1950s, all the corporations in
America had pension plans where you
would get some guaranteed payout at the
end when you retire. And they were all
like, "We're all going to go bankrupt."
Because a pension plan is either
significantly overfunded or underfunded.
If it's underfunded, you're bankrupt. If
it's overfunded, you've wasted all this
money, you can't do anything with it.
So, they all moved to 401(k)s and
everything got moved to defined
contribution plans except except
governments. And that's because the
government employees formed government
public employee unions and they're like,
"We want to keep the pension plans." And
now the pension plans, it turns out 70
years later, are going to bankrupt all
the governments in the United States.
>> That guy Spencer By the way, that guy
Spencer Pratt who's running for mayor,
he started uncovering all of the
salaries of the union folks and their
pensions in Southern California. It's
bonkers. They're making four, five
hundred thousand dollars a year right
before they go on pension. Then they
double their overtime and they get
two-thirds or a half. The pension
doesn't work. You got to go
superannuation fund. I don't know how
many times we've talked about it here,
but
>> You you don't need an annuitization
fund. You just need a 401(k). Like
people have a have an account. They got
their money in their account.
>> Yeah, but it's just a way to force
people to contribute to it. So, a forced
401(k) is different than a 401(k). You
got to force people and it's you're not
allowed to force people into the 401(k),
as you know.
>> As we've seen in California, everything
related to the government is a giant
grift, is a giant scam. There's tons of
fraud going on. Uh we've talked about
the homeless industrial complex, 12
billion a year to homelessness, but the
number of homeless keeps going up.
There's a million examples like that.
>> industrial complex?
>> Yeah, maybe it's a good time to let's
shift to SPLC cuz I think it's a good
example.
>> Well, we'll get to it. We'll get to it.
Um yeah, but you know what's even better
is you can just pass a law like the Nick
Sherly Act and you can put your fingers
in your ear, cover your eyes and say la
la la la la la and just pretend the
fraud's not happening, which is their
reaction in California.
>> Uh hey, how much fraud has Nick
uncovered so far in California?
>> Billions. He should be a billionaire.
>> Where's his
>> a billionaire.
>> You know, he should be doing it
privately and then getting the
whistleblower awards. I think that
actually would be a better strategy for
him.
>> We told him that was the We told him
that business model, remember?
>> Yeah, I know. He I think he's addicted
to the views, but I mean, he could
literally raise money on
>> Well, he's making
He's making thousands when he could be
making billions to Free Brooks' point.
>> No, he's
>> Well, but it's better It's better for
the public that he's doing what he's
doing.
>> thank god for Nick Shirley. Let's thank
Nick Shirley.
>> whether you could be making more money
or not, what you're doing is
>> And you know what he also did? He shamed
the mainstream media who's forgotten
about investigative journalism, who
forgot the ability to knock on a door
and just ask a basic question.
And now Bari Weiss with CBS has
deputized one of her reporters and she's
doing the exact same playbook and
meeting him punch for punch.
Where's CNN? Anderson Cooper should have
a Nick Shirley on his team. The New York
Times should have Nick Shirley. The LA
Times should have a Nick Shirley. Why
don't they?
>> Cuz you're
You're talking You're talking about old
media that does things one way and the
point about Nick Shirley is it's new
media. It's citizen journalism. It's
people on the street distributing
fact-finding, distributing information
gathering and old media in order to
survive became an opinion organization.
>> Didn't the media used to care that the
Pentagon was paying $900 for a hammer or
what have you? I mean, like 60 Minutes
used to do things. Now, it's like the
media just wants to protect the waste,
fraud, and abuse
no matter how egregious it is. Remember,
I mean
>> Remember that guy, Dennis Kozlowski, the
CEO of Tyco, who went to jail and they
like had it just a feeling because he
had
>> He umbrella stand the like the $6,000
umbrella stand.
>> Made out of like ivory from like
>> [laughter]
>> a rhino elephant.
>> I know you bought that at auction,
didn't you, Jim Matt?
>> Sachs, you're so right. People really
used to care except when it was their
team. And then the minute that it was
their team, they're like, "Oh, no, no,
no, let's just look the other way."
>> It was a
>> If it's a CEO, if a CEO basically
engages in some misbehavior, and I'm not
defending it, the press will be all over
that. But when the government does it,
they don't do anything.
And in fact, we had one of the most
successful, probably the most successful
entrepreneur of our generation donating
his time to the government to find
waste, and the media basically drove him
out of that.
>> They vilified him and drove him out.
>> Yeah, they made it untenable.
>> Well, this is whoever comes up with a
way to eliminate waste, fraud, and
abuse, like Chamath did, and they
productize that and make them that make
that their platform, that's the way to
win in 2028 and going forward is to
convince the public that they don't need
to have their taxes raised, they could
have their taxes reduced just by
eliminating the minimum of 20 or 30% of
waste, fraud, and abuse there is in the
system. Uh we'll get to Tim Cook
stepping down in just a moment, but I
want to remind everybody
liquidity sold out. I'm sorry, we added
a couple of tickets. We we we burned
through them immediately. But you can
still get into the All-In Summit. This
is our fifth edition in Los Angeles,
September 13th, 14th, and 15th.
allin.com/events to apply. Please apply,
and then don't come to us 60 days out
and say, "I didn't get a ticket.
I'm a bestie, get me in." Just buy your
damn ticket and don't get left out.
>> I have a liquidity announcement.
>> Oh, yum, yum.
>> We are going to do one
political panel.
>> Okay.
>> And it's going to be
Dave McCormick and John Fetterman, the
two sitting senators from Pennsylvania,
on stage with us
talking about all topics from a left and
right perspective.
>> Amazing. So, Fetterman's coming, which
means the dress code is now sandals, uh
shorts, and a T-shirt. That's great.
>> Construction Construction sheet.
>> Get your Timberlands [laughter] out.
I mean, is he really going to show up
looking like a hobo? I love his hobo
style. It's great.
>> McCormick's very fit and handsome. So,
like he he'll balance him out. So, I
think
>> That's what we should program it as.
Like, he should wear his best Brioni
suit versus
the Old Navy from Bettermint. Who
[laughter] wore it better? All right,
listen. Just rapid fire here on the Tim
Cook
resignation and moving on. This guy,
John Ternus, is a 25-year vet. He did
lots of hardware, worked on iPad,
AirPods, and he was the favorite on
Polymarket since day one. He's a bold
decision-maker according to reports. And
unlike Tim Cook Cook, Tim Cook did a
great job of squeezing every last nickel
out of Steve Jobs' product line, which
lasted for a decade, iPhone, Apple TV,
Watch, I don't have to need to repeat
them. But, here we are.
We got a product person in the seat,
which is what we all know they needed.
Because, hey, these tools are getting a
little bit stale. Siri, disgraziad.
AirPods, disgraziad. The whole system is
not built on innovation anymore. It's
built, Freeberg, I think you would
agree, on just bringing more profits,
more profits. What's your hope here?
Because, man, they missed so many great
swings at bat. They didn't get the
Oculus, you know, Ray-Bans that Meta
did. They canceled their self-driving
car. What would you hope that this new
CEO of Apple focuses on, Freeberg, in
terms of innovation? They don't have a
problem selling phones still. They don't
have a problem selling laptops and
making a ton of money. But, if you were
in the seat, if you were on the board of
Apple, which wouldn't be a bad idea for
them, if I'm being honest, what would
you tell the new CEO to focus on, David
Freeberg?
>> I mean, I don't know. The software layer
of the future is not the software layer
of the past. So,
>> Okay.
>> It's pretty obvious. I don't know if how
much there is to talk about, but you
just need the Siri equivalent that's
ubiquitous in all of your devices, knows
who you are, personalized to you, sees
your email, sees your calendar entries,
knows what kind of music you like, has
connection to your home. Basically,
build that AI layer for your life. And
make it ubiquitous in all of your Apple
devices, that no matter what device
you're using, it knows who you are, you
can engage with it using kind of a
natural language method. And it's, you
know, it's it's pretty obvious.
>> Yeah.
They should buy WhisperFlow, yeah. I
mean, that would be
>> I don't know how they're I don't know
how they're running the business, but
>> Well, they're running it for profits,
obviously, Sachs. I would say buy
WhisperFlow and just replace the Siri
team with that, because Siri's been just
The fact that Siri can't spell
Polyhymnia or Calacanis after 20 years
of us giving them $20,000 for iPhones is
just disgraceful. Sachs, if you were on
the board of Apple, again, not a bad
idea, what would be your hope for the
company? What would be your sage advice
for the new CEO?
>> Well, I mean, everybody is going to be
asking the same question, which is what
are you going to do about AI. I don't
know that they needed to be on the
bleeding edge of it, but they are going
to need an answer at some point, and
Siri's going to need to be AI-empowered.
Probably the way it should work is that
you get to choose your model. I mean, I
don't know that they need to pick just
one model provider. It could be a
setting where you go in and you set up
your account with whatever ChatGPT or
Grok or Claude or what have you. And you
can choose your own model provider, and
then you'll have more customization and
more
ability to control your your storage.
Let me just say this on Tim Cook's
retirement, he had an incredible run as
CEO of of Apple. I mean, he ran it very
effectively for 15 years. The market cap
of the company went up by over 10X, the
revenue grew from roughly 100 billion a
year to over 400 billion a year.
He also improved the quality of revenue
by moving the mix into services, which
is probably why it got why it got a
higher valuation.
And, you know, people say that well,
they never did any innovation under Tim
Cook, but you know, I've seen people
tweet list of products that were
released under him.
And there were a lot of them. Now,
it's true, nothing as big as the iPhone,
but they did release a lot of products
under Tim Cook. And then just finally, I
mean, you you look back over the last 15
years and there really weren't any
public snafus or scandals or imbroglios
with with Apple. It's one of the few
tech brands that is still, I think,
beloved by the population.
I think a major part of that was Tim
Cook's dedication to privacy and keeping
the company on the right side of that,
which I think users do appreciate. And,
you know, he even Tim Cook even got
praise from the president. I think it
was just unsolicited where the president
talked about how Tim Cook didn't call
him up that often, but when he did, it
was something important and therefore
the president tried to help them out.
Seems like he nurtured a good
relationship with the president over
over the last decade or so. So, you just
have to say that he navigated what could
have been a turbulent period with a
great deal of grace and aplomb.
>> Clearly, Chamath, he was a great steward
of the brand, even though that list of
products were all
developed under Steve Jobs and they were
just executed well, but he didn't
bring in a lot of new products or
services. Any final take
>> Actually, Chamath, can I kindly ask you
a question? What do you think
other than AI, you know, AI-powered
Siri, let's say.
What do you think he missed? I mean,
what should Apple have done that they
didn't do?
>> They would have out by now a pair of
glasses that weren't 17 lb like the
Apple Vision Pro. They would have gotten
glasses that pair perfectly with your
phone, take videos for kids, and they're
coming out with it. It's just on a
really broken timeline. They would have
had a killer Siri.
They would have had a search engine-ish
Perplexity like product. They would have
had a self-driving car. When you went to
the Apple Store, you would have been
buying two or three very important
products. Glasses, a car, and probably a
television set. If you look at actually
what they did innovative under Tim Cook,
I think that they have great taste and
Apple TV produced a lot of great
programming. I he was working on a
television set. Not Apple TV clunked
onto the back. I think those three
products would have been four products.
Siri, glasses, car, television set.
Those would have been extraordinary. And
who knows what he would have come up
with. When they lost Jony Ive, and
obviously Steve Jobs passed away, they
lost the soul of the company. They lost
the innovative, groundbreaking soul of
the company, and they just went into
profit
and iteration mode. But no acquisitions
of note. Nothing important was acquired,
and nothing important was released.
Vision Pro, you can give them like maybe
that's like the sixth best product or
something. But it obviously hasn't hit
the mainstream. Chamath, any final
thoughts from you?
>> Yeah, I have um
three specific things to say. The first
is that he had honestly like an
impossible job.
It's sort of like you play
basketball with Michael Jordan, and then
you're asked to be Michael Jordan.
And I think that that's an impossible
task. And on that dimension, I think he
has done just an incredible job. He has
been
an incredible steward of the business.
Sachs is right, no major snafus. I think
he did a really smart thing around
doubling down on privacy. And just as a
practical matter of being a great CEO.
Like if you I think you can categorize
CEOs in two buckets. One is
the innovator,
the person that's pushing the envelope,
and then the second is just a great
steward.
He's at the top of the top of that
second category. Um I sent you couple of
charts to to show this. And he found a
lane that allowed him to separate
himself from Steve Jobs. So, you know,
as an example, like what does it mean to
be a steward? Well, when you're a
steward, you're allocating resources,
and the two most important resources you
control
is capital
and people. And I think on that
dimension, what Tim did, if you just
look at this, is
he was able to invest appropriately in
R&D. They completely divested their need
of Intel. They spun their entire new
line of silicon. That silicon, it turns
out, and this will be important in the
future,
is very useful
in AI with all of this open claw stuff,
and you know, some of you guys are
completely addicted to it.
And they've kept the acquisitions light.
So, he was very capital efficient. If
you look at the
the next chart,
what's so interesting is like it is the
exact opposite of what Steve Jobs did.
Look at the amount of money that Steve
Jobs returned to shareholders in his
tenure at Apple. It's easy to count. It
was zero.
He loved to to keep that money on the
balance sheet, and he probably, or
maybe, I'm guessing, would have directed
that at some huge shot on goal. In the
Tim Cook era, it was very different. He
shrank the share count by almost 50%. I
think it's like 44%.
>> That's insane. Is there any
corollary to that, Chamath?
>> No, he's he's been a prolific
shareholder friendly CEO, finding ways
to give us money back, which I think
everyone who's owned the stock
has very deeply appreciated.
The last thing I'll say, though, is what
is the future for John Turnus, and I
think it's in this final chart. We
talked about
the problematic nature of increasing per
unit pricing in SaaS.
And what I would say is if you look at
the iPhone,
the unit price has gone up, and people
would say, "Yes, but the capabilities
have gone up in turn, and I acknowledge
that.
But the problem with the per unit
pricing being as high as it is is what
Freeburg says is going to happen. AI
rips open the canvas
of the devices that we will use to
interact with information and knowledge.
We are going to live in a much more
heterogeneous world in the future. It's
not going to be two devices and two
different operating systems that get you
to knowledge.
There's going to be all kinds of stuff.
Pens, orbs,
who knows, Jason? Your glasses,
whatever.
And so, the problem is if you get too
addicted to a single thing
that has an incredibly juicy profit
margin and great stickiness and the
ability to raise price,
it's a hard drug to get off of. So, I
think really what John Turnus has to do
is figure out how to move to this world
where everybody will be launching
umpteen devices
via MCP or otherwise,
all of these services will be open.
It'll be agentically talking to
everything. I think the most decay.
And I think if that happens, that's
problematic if you're too reliant on a
single thing to kind of keep it going.
>> Yeah, and just expanding on what you
said, like wearables is where they
really uh made some good inroads in
terms of getting people to use them,
whether it's AirPods or the watch. And
the next wearable, like this is an
applaud pin that I use to record. You
can put it here, put it on your wrist.
That AI synchronicity of having your
eyes, having your ears, having your
watch, having your phone, your desktop
all sync together with AI could be a
huge product line. I'll also add a
fifth, robotics. You know, the I think
to I think Steve Jobs, if he were alive
today, would have been looking at
Roomba, he would have been looking at
Optimus, and he would have said, "Hmm."
>> [clears throat]
>> Consumer robotics, in addition to a
consumer car, those are two things I
think he would have absolutely uh
executed on at a high level. Okay, let's
keep moving here. Uh
>> Just come and come and one last point.
>> Chamath, we'd love to have you on the
pod, John. So, just come on the pod when
you're ready. Uh we'll have you come sit
in. Go ahead. Sachs, you get the final
word.
>> This one last point on this is that I
think the succession at Apple
is reminiscent a little bit of the
succession at Disney.
And apparently
Steve Jobs and Tim Cook had this
conversation back when Steve was alive
and and Steve
told Tim, "Don't do what Disney did."
Where basically after Walt Disney died,
the company kind of languished because
it felt so beholden
to Walt's vision that they never really
iterated. Now, when Walt died, his
brother Roy took over and Roy was
already in the business. He was sort of
like the business co-founder. He was a
COO type, a little bit like Tim Cook.
And he kept the magic going for about 5
years and then he himself died. I think
it was around 1971. And then you had
this string of CEOs who took over were
kind of uninspired and it wasn't until
Eisner came in in 1984 that he sort of
revitalized the business.
And so, as I understand it, Steve and
Tim had this conversation.
And Steve told him, "Don't be too
beholden to my vision. You need to
figure out your own and extend it."
I think that, you know, you could argue
that Tim in a way was like the Roy
figure here. Very effective business
partner
of Steve. He got a 15-year run. Roy only
got five and I think again, he added a
zero to the value of the company. The
market cap went up over 10x. So, you
have to say fantastically successful run
as CEO. I think the question now for
John Turnus is, "Okay, you're now past
let's say the the Walt Disney and Roy
Disney part of the business. Is it going
to be like the 1970s
Disney or is it going to be more like
the 1980s? Do you figure out a way to
revitalize it or do you have to go
through
uh you kind of a funk first?
>> Mhm. Yeah, and if I I think it's like
really illustrative of this discussion,
Eisner and Iger. Cuz Eisner's innovation
was he realized that Disney was uh I
think he called it the vault strategy.
He would and we probably remember this
from our childhoods, he would re-release
all into theaters all of their IP every
7 years. You couldn't get some of those
Bambis, whatever.
Snow White and the Seven Dwarfs, you
couldn't get those products except in
theaters and he figured out a cadence to
keep publishing. But then Iger came in
and said, "Hey, what if we use this
balance sheet and we use this
distribution at the parks uh and you
know, with their brand
to buy Pixar, Marvel,
uh and Star Wars." And so, there's
multiple ways to do it. There might be
something there in terms of
acquisitions, bold acquisitions with the
Apple balance sheet could be super
accretive to shareholders as opposed to
lowering share count and just
distributing a ton of cash. All right,
listen. We're going to talk about the
Southern Poverty Law Center racism
corner. Let's go to race Fake fake
racism corner.
>> I want to know how the SPLC managed to
accumulate 822
million dollars in offshore bank
accounts.
>> Yeah.
>> This is incredible. These are big
numbers. Okay, SPLC
>> How was that possible? What is going on?
>> All right, let me tee it up here for the
team.
>> It's like one of the biggest grifts of
all time.
>> Anyway, Jake has to do it. This is a big
one. SPLC has been indicted indicted,
not found guilty yet, on 11 counts of
wire fraud and money laundering. Keep
that in the back of your head. Wire
fraud and money laundering. Here's the
core allegation. Between 2014 and 2023,
the Southern Poverty Law Center used
hidden bank accounts to funnel 3 million
in donor money to paid informants.
Like these are confidential informants,
like the police or FBI might use. They
use these as a non-profit NGO to
infiltrate hate groups. And so, the
official mission of the SPLC
is, quote, to be a catalyst for racial
justice in the South and beyond, working
in partnership with communities to
dismantle white supremacy, strengthen
intersectional movements, and advance
the human rights of all people. Okay,
sounds great on paper. Examples of
organizations they were trying to
infiltrate great KKK Aryan Nation
neo-Nazi groups, and the Unite the Right
organizers. Proud Boys, labeled as a
hate group by the SPLC. Oath Keepers,
not listed as a hate group, but part of
the militia movement. My friend Sam
Harris, he was not listed as a hate
group, but he was also pinned by the
SPLC as, like, hate adjacent in their
Hate Watch headlines. And this is
something that I had a major problem
with this organization on, which is they
would just very loosely label people as
hate speech and try to get them
canceled. All of this kind of came to a
head. The revenue before
Charlottesville, you remember the
incorrectly clipped uh Charlottesville
hoax, where they said Trump said both
good people on both sides, but they
didn't give his full quote. Very unfair
to President Trump. Uh we found out
later.
And that was the reason Biden
of course ran. He said the
Charlottesville both sides thing was his
inspiration. 58 million in 2026, to your
point, Chamath. Doubled and spiked to
136 million, more than double. And it's
remained elevated ever since. Here are
some, you know, images. For the
indictment, and I'll wrap on this and
then get everybody's uh feedback. They
had F-37 as one of their confidential
informants. He was a member, and this is
according to the indictment, quote,
member of the online leadership chat
group that planned the 2017 Unite the
Right event in Charlottesville,
Virginia, and attended the event at the
direction of the SPLC.
F37 made racist postings under the
supervision of the SPLC and helped
coordinate transportation to the event
for several attendees between 2015 and
2023. The SPLC secretly paid F37 more
than $270,000.
That's the legal case here. Let me pause
there.
>> Can I add one thing?
>> Sure, keep adding. There's a lot of
detail to this case. Yeah.
>> Yeah, so you're right that the SPLC
allegedly did fund $270,000 to help plan
Charlottesville. In addition to that,
they secretly funneled more than $3
million
to
to a bunch of violent racist extremist
groups including the Ku Klux Klan, the
American Nazi Party,
Aryan Nation,
United Klans of America,
and it goes on from there. So, I think
don't forget about the $3 million bucks.
So, this group that was supposed to be
fighting racism in fact was fomenting
racism by paying these groups to
basically organize protests
that SPLC could then point to and say
that America has a huge racism problem,
donate to us. And that's basically what
happened after Charlottesville.
They increased the amount of money that
they were able to fundraise by $81
million. So, that $270,000 investment
led to an $81 million return, pretty
good. But this is kind of the whole
point of the story is that these guys
are basically running a grift. And one
of the ways that you know this is a a
grift is because according to the
indictment
that they opened bank accounts under
fictitious entities to conceal the
payments that they were making from
their own donors.
Because if their donors knew
that they were funding the KKK,
they wouldn't be getting all these
contributions from Hollywood celebrities
and all the rest of it. So, it's really
just this unbelievable story.
>> Under
>> Uh it It the mind.
>> And just to clean up a little bit there,
these are allegations. They haven't made
the jump from planning these events and
the SPLC
claims they were not planning these
things, they were monitoring. So, that's
going to be their argument on the side.
I'm not saying I agree with that.
>> I know. I know. You're You're You're
right that the SPLC's cover story is
that they were simply paying informants.
That's what they've claimed.
But, there's two problems with that
story. Number one is they were paying
the actual leaders of these groups, not
just sort of moles who were infiltrating
the groups. And second, these leaders,
they weren't paid to inform, they were
paid to foment the activities. So, I'm
just saying that's the the flaw. I
understand they have this cover story
that they were just paying informants.
I'm just saying in my view, that does
not hold up. And again, if they were
just paying informants, why the
extraordinary efforts to conceal the
payments from their own donors? If they
were proud of these efforts to
infiltrate these groups, they should
have basically informed their donors
what they were doing. In fact, they hid
it.
>> And well, here's the reason uh that it
was hidden, according to them. Again,
I'm not taking the side. SPLC is not an
organization I'm endorsing in any way.
Their version of this is we didn't plan
any of this.
If we put
SPLC
bank accounts together for informants,
that would be like the FBI sending a
check to an informant from an FBI
account. That's their explanation of it.
>> They're not a law enforcement agency.
>> Well, that's actually the question I had
about all this is like what is a
nonprofit doing hiring confidential
informants, Chamath, to infiltrate these
organizations, to what end? And then if
you show me an incentive, you're going
to you're going to see an outcome. And
the outcome here is, "Hey, we'll get
more donations if there's more racism."
Uh your thoughts, just generally
speaking here, Chamath. Again, all of
this is alleged.
>> These NGOs have completely run amok.
They're cause-playing as these
overlords and power brokers in our
lives, and it needs to get stopped. They
should all be dismantled. The people
that donated to the SPLC should sue
them.
Rip open all of the documentation, get
their money back. Because just so you
guys know, if you are listening or
watching and you have donated, there's
$822 million of your money sitting in an
offshore bank account waiting for you to
get it back. Okay? And then separately,
if you are thinking of donating to any
of these organizations in the future,
unless there is a
full transparent auditing of it, you
actually may be doing the opposite of
what you thought. If you are against
racism, you may be supporting racism. If
you are against discrimination for gays,
this could be actually promoting
discrimination for gays. If you are
supportive of trans rights, this may be
pushing back against trans rights. Cuz
the playbook seems to be do the opposite
to create the narrative, give it to your
friends in the media who will look the
other way and just amplify it, tell the
lie, create the craziness, and then
raise a bunch of money, make a bunch of
stink, and try to
curate power.
>> Friedberg, you think this is
in your estimation or your gut tell you
this is arsonists
firefighters? They're lighting things on
fire so that they can go put it out.
Or do you think this is like
a law fair as some people are claiming
because there hasn't been to Chamath's
point, it's they don't have donors
taking this action. They're being
accused of wire fraud on behalf of
donors who haven't shown up yet to do,
you know, a legal action. What's your
take on all of this, Friedberg?
>> The IRS definition of what a 501c3
nonprofit organization is meant to be
doing is to engage in exempt activities.
The definition of exempt activities is
charitable,
religious, educational, scientific,
literacy,
public safety,
or fostering amateur sports competition
or preventing cruelty to children or
animals.
You tell me how the [ __ ] 90% of what we
call nonprofits today fall under that
definition. We have completely closed
our eyes to the fact that organizations,
regardless of political affiliation,
social interest, have fundamental
commercial and probably not aligned
interests with the definition of a
501c3, and we've allowed them all to get
away with it for far too long. I don't
think that this is a blue or red thing.
I think that this is a thing where we
let these organizations make it easy to
get money, to hide the money, and to do
whatever the hell they want with the
money, and we need to stop it. And I
think that it's an amazing opportunity
right now for everyone to kind of reset
the decks by cleaning all the [ __ ] up
and getting all of these organizations
flushed and make sure that any
organization that wants to do whatever
[ __ ] nefarious things they want to
do,
by all means do it. But it's not a
nonprofit, and you shouldn't get a
charitable donation deduction, and the
government should not be putting money
into these sorts of things. This is an
entirely different sort of activity in
the social order. And as a libertarian,
I'm all for it, but I don't think that
they should be tax-exempt, and I don't
think they should be getting government
money, and I don't think that
individuals should be benefiting from
giving them money. And if we could fix
all that [ __ ] up, I think a lot of these
problems are going to go away, and I
think this is a major problem.
>> I think the theme of this episode is
audit everything, whether it's
government waste and abuse, or it's
these NGOs, or it's people like Dow
making these chemicals that 30 years
later, you know, perhaps are correlated
with cancer. We need to audit
everything. We need to take a fresh look
at this cuz it's not red versus green.
Red This is not red versus blue. It's
green. This is clearly a monetary
incentive, and it is incredibly
disruptive for society to not know the
truth about
what's going on with race in this
country. I got
absolutely, you guys might not know
this, but in this is part of the cancel
culture moment in time where they tried
to take people having reasonable
discussions about race in this country
and tried to cancel them. They tried to
do this to me in 2014.
Very famously, you guys may not know
this, but I have won a couple of awards
in my career. Most offensive tweet ever
by Vice in 2014 was my
alleged racist tweet where I said, "Hey,
if you want to get into uh blogging and
journalism, there's no racism in Czech
journalism. All you have to do is
publish for a couple of years a blog
post, nobody can stop you, and there'll
be a ton of jobs available to you." And
then what they did was they tried to
cancel me and tried to cancel all my
media properties and my investing.
And this stuff had like a modest impact
on me maybe for a year.
And then now it's obviously all being
>> Whoa, whoa, whoa, wait. I'm not sure I
understand. [clears throat] J Kyle,
you're saying the SPLC put you on a
cancellation list?
>> No, they put Sam Harris on it. Vice put
me on a cancellation list. I It didn't
get picked up by the SPLC, but I
experienced the same thing, which was
they said because I said
you know, race does
race doesn't play a role in hiring.
>> You're so careful about your virtue
signaling. I'm just shocked that anyone
would try to cancel you.
>> Well, that's what's shocking about it.
It's like [laughter]
I know I was very clear. I said, "In
journalism, like a very vertical thing
that
>> skilled at experiencing You're very
skilled virtue signaler, so
>> [laughter]
>> I mean
>> They tried to cancel me, guys. I don't,
you know, it's They tried to cancel you,
too, Jamal.
>> Jason, go ahead.
>> You have a question for me?
>> I'm uncancelable.
>> Yes.
>> Cuz I don't give a That's what we found
out through all this shenanigans. You
care about all what all these idiots
think. But
>> don't. I never have. [laughter]
>> Jason, I have a question for you.
>> Go ahead.
>> What percentage odds now do you keep in
the back of your mind that your
petite little illustrious Human Rights
Watch
>> [laughter]
>> is actually creating human rights abuses
to try to
>> This is actually a very good point. You
know, a lot of the human rights
organizations from back in the day that
>> What is the organization that you were
What is it called?
>> Amnesty International.
>> Oh, yeah.
>> When I worked at Amnesty International,
a very fine
mandate. The mandate was human rights
abuses as described in the Universal
Declaration of Human Rights created by
Eleanor Roosevelt and the uh
>> This is like science corner. Wait until
this is done, Sam.
>> No, but they It was torture. [laughter]
It was people being put in jail and
being tortured. It was people being
censored because of freedom of speech.
And And that's what I worked on when I
was at Amnesty International. These
groups went adrift in order to get
money, Human Rights Watch included, and
then they started taking on things like,
you know, uh transgender rights, this
rights, that rights, and censoring
people. They They went after Sam Harris
because he had Charles Murray from the
Bell Curve.
>> with all this [ __ ] I'm asking you a
very specific question.
>> chance that all these organizations are
involved in human rights.
>> 50/50 chance
>> Depending on the organization. SPLC, I'm
going to guess 95%. Yeah.
>> Amnesty International, you think is
50/50 that they're engaging in nefarious
[ __ ] to try to whip up people's
belief that there are human rights
abuses happening that are not happening.
You're saying it's a coin flip.
>> I think it's probably a coin flip, yeah.
That's what I would say today because
these organizations all got co-opted.
SPLC might have had a great origin
story, but now it is
>> your intellectual honesty and I
appreciate you saying that.
>> Well, I mean, just based on facts. So,
let's see what this
legal case brings about.
>> Well, let's be clear. This is not Let's
be clear.
>> them investigating SPLC, 100%.
>> When you bring a grand jury indictment,
you've already previewed the evidence.
This is not like some guy's trying to
whip up lawfare.
Okay?
>> Um actually, you don't have to bring all
the evidence, but that's a side thing.
And And they're very frisky about
allowing you to indict somebody as we
experienced with Trump.
>> Grand juries are a whole different
animal.
>> Yeah. They They will indict a ham
sandwich is the line. Um so, we'll see.
Let's give them their day in court is
always my position.
>> Well, I mean, regardless of what happens
in court, if it's true that the SPLC is
funding the Ku Klux Klan and the
American [laughter] Nazi Party,
>> ago, just so we're clear. They stopped
using confidential informants.
>> That's good enough for me.
>> loud, it's insane.
>> It's good enough for me.
>> You know, it's insane.
>> Here Here's the systemic problem with
nonprofits and NGOs. Is Let me just
contrast it with business. In business,
you set up a company, the company has to
make revenue, it has to make profits,
and if it doesn't, it's going to go out
of business, right? Because it'll lose
money. So, there's a feedback mechanism
from the market. The company has to
create products that people are willing
to buy, and those products have to make
money. With an NGO, nonprofit, what have
you, they raise money, they don't sell
things, they fundraise from donors in
order to engage in an activity. But what
happens over time is the actual
activities may stop mattering, and all
that really matters is they're able to
keep fundraising, right? Because they're
just trying to figure out a
justification to keep going back to
donors to get more and more money out of
them. That's how it perpetuates the
organization.
>> And they're trying to keep their job.
>> Exactly. And then, if it's an NGO that
gets money from the government, then
it's even worse, because all they do
from that point forward is try to lobby
the government to get more money. And it
doesn't really matter whether the
program is working or not. All that
matters is whether they can spin it as
working.
>> Why wouldn't the Southern Poverty Law
Center focus on Southern Poverty, which
is an issue that actually still exists
in some parts of the
>> Shouldn't that be a better thing? I
mean,
and why do you call it one thing, focus
on racism, and then all of a sudden whip
up
>> I'll tell you why. Here's my theory.
Here's my theory on it. Is I do think
that at one time in this country, civil
rights was a noble cause, a very
legitimate cause. We had the the legacy
of segregation and Jim Crow, and there
were groups that were set up to
basically change that, and they
succeeded.
But again, no one in an NGO or a
non-profit ever declares victory.
They're never going to say, "You know
what? Like we we addressed this problem.
We solved it." You know, I always
thought that in 2008 when when
>> me. Fire me. My job's done.
>> Yeah, well well when Obama got elected
in 2008, I thought that regardless of
whether you liked Obama or not or agree
with his politics, I thought that at
that point most people could see that
this was not a racist country.
>> 100%.
>> Whatever else you could say, the fact
that the highest office in the land was
not denied to any body showed that this
country was not holding people back
based on their skin color.
And instead of just basically packing up
shop and saying, "Okay, we've achieved
our goal."
>> [laughter]
>> The goal posts all got moved. Remember,
that's when the whole anti-racism thing
started was was around Obama's second
term. And what anti-racism was, it said
that
it's not good enough not to be just not
to be racist. You actually have to be
anti-racist, but what anti-racism meant
was was basically that all the
distributions had to match the
population. Basically, it meant equality
of outcomes, not equality of
opportunity. So, effectively
this whole goal post was moved from
equality of opportunity to equality of
results.
>> you see it, you can't unsee it. It's
like they sat around and they said, "Now
what?" And one person was like, "I got
an idea."
>> [laughter]
>> Well, and make race a symptom again.
>> Exactly.
>> if they just said if they just said at
that time, "You know what? We're going
to move the goal post from equality of
opportunity to equality of results.
We're going to basically make everyone
equal at the finish line, which is to
say I guess communism or or some sort of
identity socialism." People would have
said, "Uh no, we're not on board for
that." So, instead they created this
whole new terminology to justify it. It
has taken us years to unpack that and
realize what's really going on.
>> Gosh, I don't want to put myself in a
position of defending the SPLC. They
were partners with the FBI for a long
time. To your point, Chamath, or or
Sax's point, rather. There was probably
a time when it was important to
infiltrate the KKK and the Nazi groups.
>> It's not 2025.
>> not in 2026 like I think necessary to be
doing this work. I think more than four
people can handle it. Uh in 20 26.
>> to give you guys a newsflash. I just got
this just hit the wire. Um this is
really important.
>> Breaking news here.
>> America is profoundly less racist than
you think, okay?
>> There we go. Okay, breaking news.
>> Wake up.
>> Friedberg wanted to do a surprise
science corner. This is the first. We
don't know what he's about to talk
about, but David looks like he's been
working really hard and he needs a nap,
so Friedberg, you have the microphone.
Let's go.
>> This was not
>> Surprise science corner.
>> Yeah, this is not necessarily a big
surprise, but there was a really
interesting paper published this week
on trying to elucidate the underlying
cause or predictor of colorectal cancer.
So, I don't know if you guys know any
young friends, but colorectal cancer or
Nick, if you could just pull up this
first image, or colon cancer
has become now the third leading cancer.
Over the last 20 years or so, there's
been a scary rise in the number of young
people, people generally under 50 years
old that are getting colon cancer. That
number has climbed by
over 80% in just the last
two decades.
Historically, it's been an age-related
disease. So, as you get older, over 70
years old, your probability of getting
colon cancer shoots through the roof,
but this rise in young people getting
colon cancer has been pretty alarming,
and there's been a real question mark on
what is causing it. What's the
underlying
trigger.
So, this research team out of Barcelona
in Spain did an amazing study
where they looked at the difference in
the epigenome or the gene expression
in tumor cells
of patients that are under 50 years old
and those that are over 70 years old.
This sort of data will show you what
different environmental triggers are
associated with those changes in gene
expression. So, whenever we're exposed
to something in the environment, whether
it's some food or some drink or whatever
else it is, some chemical in the
environment, the cells in our body that
are exposed to that chemistry or exposed
to that environmental trigger
have genes that get switched on and off.
And you can see which genes are on and
off by looking at the RNA of those
genes, which tells you that those genes
are expressing RNA to make protein or
not make protein. And you can look at
that gene expression to determine what
is changing when a cell is exposed to a
particular environmental trigger. And
so, they were able to get these samples
of colon adenocarcinomas
from the Cancer Genome Atlas, which is
funded by the federal government. And
they were then able to take a look at
these cancer cells from colon cancer in
patients that are under 50 and patients
that are over 70, and look at the
difference in the gene expression
profile
and what um environmental triggers are
associated with that gene expression
profile. So, that will tell you, "Hey,
these environmental triggers are more
likely the cause or an underlying driver
of the risk of getting this colon
cancer."
And one thing rose to the top. So, they
looked at a whole bunch of things. They
look at lifestyle factors, they look at
eating index, how much you ate, how
overweight you were, alcohol, birth
weight. They adjusted for gender, they
adjusted for all these different things.
And as you look down this list, you'll
see this is the difference between
people that got colon cancer that were
over 70, when you typically have a very
high chance of getting it, and people
that are under 50, when you don't. And
what is going on with people under 50?
And you can see there's this one row
here that's all orange.
That row is a pesticide called picloram.
Picloram is a pesticide that was
developed by the Dow Chemical Company
in 1963.
This is the
chemical formula for that pesticide.
It's related to auxin, which are these
hormones that plants make. And in the
1960s, there was this big rush to try
and make synthetic plant hormones that
you would then apply to a plant. It
would cause the plant to overgrow, and
the plant would quickly die. And
picloram became a very widely used
herbicide
in our environment. It's used to manage
weeds in rangeland and pastureland where
cattle graze. It's used to control weeds
near roads and near railroads, on
industrial sites to clear weeds away
from highways and utility corridors. And
the problem with picloram, one of the
the things that's been known about it is
it's very persistent. It doesn't
biodegrade very well. Picloram sticks
around for well over a year. It stays in
the water. It moves into groundwater,
and it's persistently in the environment
after it's been used for some period of
time. I went back and looked at the EPA
data on this chemical. The last time
there was an EPA safety study done was
in 1995.
And so this was before we had this
capacity to do epigenomic studies like
what was just done to elucidate that
even though a chemical might not be
causing cancer immediately, and you
can't apply it to a cell and see it
trigger a cancer,
the long-term use or exposure to certain
chemicals in our environment causes a
change in the epigenome, which means
that these genes are being turned on and
off. And when certain genes are turned
on or off in the wrong way, it can
trigger cells in the tissue to start to
malfunction and go haywire, and
ultimately lead to cancer. And I think
that this paper shows a pretty strong
effect of picloram in driving colon
cancer in young people. It will very
likely lead, and it should lead to an
EPA review on whether this should be
legally allowed, but it should also lead
to a new mechanism by which we assess
chemistry that we're using in our food
supply, in our environment, in our
industrial applications, because we can
now look at all of this at sort of
epigenomic data to try and figure out
what are these chemicals doing to us
before we see them cause the problem.
So, I thought this was like an amazing
paper done by this team. They did a lot
of work to try and make sure that the
statistics were sound in the studies
that they did.
It really
uh I think elucidated something pretty
scary.
>> Is this like a Monsanto thing where like
one company makes it or
picloram is broadly available?
>> It's off patent now and so I'm pretty
sure my guess, I haven't looked into
this, but my guess is most of this is
made generically in China and then it's
probably packaged up with lots of
different brands in the US and all over
the world. So, it's one of these
chemicals that's just become ubiquitous
in our use
that just shows up everywhere, but I
think it really speaks to the fact that
historically, think about 1995, you can
look at what the immediate chemical
application of something does to a a rat
or a human cell and you can say like,
"Oh, it didn't cause cancer. It's good
to go. Let's go." You know, didn't
didn't cause quote toxicity.
>> Can I ask a question? In that study, are
you exposed to picloram based on where
you live
>> Oh, yeah. Sorry. That's a that's a great
question, Chamath. So, I was going to
talk about this. Thank you for asking
that. They then took that uh picloram
exposure and then they looked at all the
counties across the United States. They
were able to gather data where there was
enough data in California, Connecticut,
Georgia, Iowa, New Mexico, Utah,
Washington, and they were able to look
at picloram use estimates from the
Pesticide National Synthesis Project and
try and deduce in places where picloram
was highly used and not highly used. And
once again, it elucidated signal, which
is that when picloram was used in the
environment in the counties more
frequently, there was a much higher
frequency of colon cancer in those
counties.
>> And that R squared is weak or it's
strong?
>> Reasonably strong. The odds ratio is
like 3x. It's very strong.
>> This is accomplished Freeberg from a
combination of big data
and this uh science
>> I think it's important Yeah, I think
it's important
>> testing as well, right? So, you have
this confluence of increased testing,
increased data, you know, knowing where
these instances are occurring, and if
you add a layer of AI onto this
Freeberg, this is like a really positive
use.
Going back and looking at all these
compounds and figuring out which ones we
need to eliminate.
>> Yeah, so I'll I'll put my PCast hat on.
Thank you, David Sachs, for the role.
And I think this speaks to one of the
important roles that government has in
doing fundamental science and
fundamental research. So, the the
National Cancer Institute in the federal
government stood up this genome atlas
with a hundred million dollars a couple
years ago. They spend only a few million
dollars a year now to maintain it to get
cancer tissue samples and then create
the availability to scientists to use
those cancer tissue samples to do the
sort of epigenomic analysis this and
study supported by, you know, government
grants, or in this case supported by
a foreign university getting funding to
do it. And so, there's there's an
important role that fundamental science
still has in elucidating this that we
would have otherwise not been able to
see if we didn't have this resource
available to us from the federal
government and federal funding of
scientific programs like this. And that
leads to this discovery. You don't need
fancy AI for this, to be frank, Jay Cal.
There's an incredible amount of data
that's available or or resources that
are available. What's happened in the
last couple years is what's called RNA
sequencing where you can actually look
at which genes are on or off, not just
what's the DNA, but in the DNA, remember
we've talked a lot about the epigenome,
what genes are on or off, and how that
changes when you have different cancers
or when you have different chemicals,
and when you have a certain chemical
like picloram, your colorectal cancer
goes through the roof, and you can see
that relationship in those tissues. And
then you can put all the data together
and say, "Oh my gosh, there's a lot of
evidence here that points to this
connection. Very powerful. I think it's
important that it opens up the window
that this shouldn't just be a one-off
research project conducted by a team in
Spain, but maybe should be a fundamental
role that some of the government
agencies play, which is to stop
Americans and the world from getting
freaking cancer. Let's figure out the
things that we got wrong in industry and
go back and delete them out of our food
supply and out of our industrial supply.
And I think this is a really good
example of that.
>> So X, uh, how does Freeberg's focus on
Uranus, uh, in you know, inform your
co-leading of P-cast here? Are you going
to go deep into this colon research? How
deep do you plan on going? And how will
you get through eight of these
presentations a day at P-cast?
>> [laughter]
>> All right, it's all good. This is why we
hired Freeberg.
>> Yes.
>> By the way, did you guys
>> He's going to handle, uh, Mars, Neptune,
and Uranus.
>> Absolutely. He's [laughter] going to go
deep into Uranus and clean it up. We
need to clean up Uranus.
>> Uh, great work.
>> Anyway, Freeberg, great great work.
>> Anyway, I think I think this is
important and I don't think there's any
news attention on this since it came out
a couple days ago. So I thought it would
be worth bringing up on the show and
making people aware.
>> All right.
>> But thank you guys for sitting through
it.
>> Well, no, I think it's it's great work
you're doing there.
>> I just read the paper.
>> Yeah.
>> All right, everybody. That's it for
episode 270 of the world's greatest
podcast. I am your world's greatest
moderator. Thank you Chamath, David
Sacks, and David Freeberg for the
episode. To your friends, your
neighbors, and we'll see you all next
time. Bye-bye.
>> Love you boys. Bye-bye.
>> Let your winners ride. [music]
>> Rain Man David Sacks.
>> And I said
>> We open sourced [music] it to the fans
and they've just gone crazy with it.
>> Love you guys.
>> I'm Queen of King Wa.
>> Let your winners
>> [music]
>> ride.
>> Besties are back.
>> That is my dog taking a [ __ ] in your
driveway, [music] Sacks.
>> Oh, man.
>> [music]
[music]
[laughter]
[music]
>> I'm going all in.
Ask follow-up questions or revisit key timestamps.
In this episode, the hosts discuss SpaceX's acquisition of AI coding startup Cursor, analyzing the strategic implications of integrating AI development tools with massive compute infrastructure. They also delve into the financial challenges facing SaaS companies in an era where AI-driven agents disrupt traditional software business models. Furthermore, the episode explores allegations of fraud at the Southern Poverty Law Center (SPLC) and features a 'Science Corner' discussion by David Friedberg on a study linking a specific pesticide, picloram, to rising rates of colorectal cancer in young adults.
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