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Essentials: Tools to Boost Attention & Memory | Dr. Wendy Suzuki

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Essentials: Tools to Boost Attention & Memory | Dr. Wendy Suzuki

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885 segments

0:00

Welcome to Huberman Lab Essentials,

0:02

where we revisit past episodes for the

0:04

most potent and actionable science-based

0:06

tools for mental health, physical

0:08

health, and performance.

0:11

I'm Andrew Huberman and I'm a professor

0:13

of neurobiology and opthalmology at

0:15

Stanford School of Medicine. And now for

0:17

my discussion with Dr. Wendy Suzuki.

0:20

Wendy, great to see you again and to

0:22

have you here. It's been a little while.

0:24

>> It's been a while. So great to be here,

0:26

Andrew. Thank you so much for having me.

0:28

>> Yeah, delighted. I'd like to start off

0:30

by talking about memory generally and

0:33

then I'd love to chat about your

0:35

incredible work discovering how exercise

0:38

and memory interface and what people can

0:40

do to improve their memory and brain

0:42

function generally.

0:43

>> Yes.

0:44

>> Maybe you could just step us through the

0:45

basic elements of memory.

0:48

>> Well, I like to say there are four

0:49

things that make things memorable.

0:52

Number one is novelty. If it's something

0:56

new, the very first thing uh the very

0:58

first time we've seen something or

1:00

experienced something, our brains are

1:02

drawn to that. Our attentional systems

1:04

draw us to that. And when you are paying

1:06

attention to something, that's that's

1:08

part of what makes things memorable.

1:10

Second is repetition. Third is

1:13

association.

1:15

So if you meet somebody new that knows

1:20

lots of people that you know. So you and

1:23

I share many many many many people that

1:25

we both know. It's easy to remember.

1:28

It's easier to remember you especially

1:30

if you were somebody new that I hadn't

1:32

met before. We have met before. Uh so

1:34

association. Um and then the fourth one

1:38

is emotional resonance. So we remember

1:41

the happiest and the saddest moments of

1:44

our lives and that also includes you

1:46

know funny surprising things. Uh that is

1:49

the interaction between two key brain

1:52

structures. Uh the amygdala which is

1:56

important for processing uh lots of

1:58

emotional particularly threatening kinds

2:00

of situations but uh those threatening

2:03

surprising kinds of situations. The

2:05

amigula takes that information and makes

2:08

another key structure called the

2:10

hippocampus

2:12

work better to put new long-term

2:16

memories in your brain. So that in fact

2:19

is the key structure for long-term

2:21

memory. This structure called the

2:23

hippocampus.

2:24

>> Yeah. Step us through kind of what this

2:25

structure is, what it looks like.

2:27

>> The word hippocampus means seahorse. It

2:30

is visually anatomically beautiful with

2:33

these kind of interwining

2:36

sub regions within it. So that's

2:39

anatomically functionally what does it

2:42

do? Well, it's easiest to understand

2:45

what it does when you uh look at what

2:49

happens when you don't have a

2:50

hippocampus anymore. We know this from

2:53

the most famous neurological p patient

2:56

of all time. Uh his initials were HM. So

3:00

all psychology neuroscientists

3:02

neuroscience students know him. Uh he

3:04

was operated in 1954

3:08

and the paper was published in 1957. Um

3:12

they removed both his hippocampi because

3:15

he had very terrible epilepsy and um

3:18

they knew that the hippocampus was the

3:20

genesis of of epilepsy and this was

3:22

experimental. his epilepsy was so bad

3:25

that they decided not just to remove one

3:27

hippocampus but both. And what happened

3:30

was immediate um immediate loss of all

3:35

ability to form new memories for facts

3:38

and events. So this hippocampus does

3:41

something with all of these perceptions

3:43

that are coming at us every single day,

3:45

every minute of the day. And not for all

3:48

of them, but for some of them that have

3:51

these features that we just talked

3:52

about, maybe they're novel, maybe they

3:54

have associations, maybe they're they're

3:55

emotionally relevant, maybe uh uh maybe

3:58

they've been repeated. Some of those

4:00

things uh in the realm of facts or

4:02

events get uh uh encoded in our

4:06

long-term memory. The hippocampus and

4:08

what it does really defines our own

4:11

personal histories. It means it defines

4:13

who we are. Because if we can't remember

4:16

what we've done, the information we've

4:19

learned and and the events of our lives,

4:22

it it changes us. That that's what

4:24

really defines us. But what people have

4:27

started to realize that it's not just

4:30

memory. It's not just putting together

4:33

associations for what, where, and when

4:36

of of events that happened in our past,

4:39

but it's putting together information

4:41

that is in our long-term memory banks in

4:44

interesting new ways. I'm talking about

4:47

imagination. So, without the

4:50

hippocampus, yes, you can't remember

4:51

things, but actually, you're not able to

4:54

imagine

4:55

uh events or situations that you've

4:58

never experienced before. So what that

5:01

says is the hippocampus

5:03

is important for memory is a too simple

5:05

a way to think about it. What the

5:07

hippocampus is important for is what

5:09

we've already talked about associating

5:11

things together writ large. Anytime you

5:14

need to associate something together

5:16

either for your past your present or

5:18

your future you are using your

5:20

hippocampus and it takes on this much

5:23

more important role in our cognitive

5:26

lives when we think about it like that.

5:28

That is kind of the new the new

5:31

hippocampus that that neuroscientists

5:33

are studying these days.

5:35

>> There are some memories that can be

5:38

formed very quickly. So-called one trial

5:40

learning.

5:41

>> What is it about emotionally salient

5:43

events that allow memories to get

5:46

stamped in? There is this protective

5:48

function um of our brains that has

5:51

evolved over the last 2.5 million years

5:54

that you need to pay attention and

5:56

remember certain things for your

5:58

survival. If something terrible happens,

6:00

if something very scary happens, um you

6:03

remember that and that that fear and

6:07

that memory of all those things. I mean,

6:09

I I have one uh when I lived in

6:11

Washington DC, I went to work at NIH on

6:14

a Sunday afternoon and I came back and

6:16

when I rounded the corner to my door of

6:19

my apartment, um it was crowbar barred

6:22

in. Somebody had taken a crowbar, opened

6:24

up my door and stole the nicest things

6:27

in my apartment. Ever since then,

6:29

whenever I rounded that corner, I still

6:31

had that memory. It was terrible

6:32

because, you know, it put me in a

6:34

terrible state when I was just coming

6:36

home. And that that's a survival

6:38

mechanism. Do you want to uh be alert to

6:41

possible danger? Absolutely. Yes. So

6:44

part of those one trial memories I think

6:48

is often taking advantage of this

6:50

evolutionarily developed system to tamp

6:54

in things that could be potentially

6:56

dangerous to you into your memory. So

6:59

you forever will remember this

7:02

particular corner or this this hallway

7:05

because that is where something really

7:07

bad happened to you.

7:08

>> For people trying to learn information

7:10

that they're not that excited about,

7:12

right?

7:12

>> Is there something that we can do to let

7:15

to leverage knowledge of how the memory

7:16

system works naturally to to make that a

7:19

a more straightforward process? Maybe we

7:22

could talk about your story and how um

7:24

you came to the place you are at now

7:28

>> because I think it provides a number of

7:29

tools that people could um implement

7:31

themselves.

7:32

>> Yeah. Yeah. As I was working to get

7:35

tenure at NYU and and as you know it's a

7:38

it's a stressfilled process. They give

7:41

you six years to you know show your

7:43

stuff and you are judged in front of all

7:45

your colleagues and either they say okay

7:48

you can join the club or they say sorry.

7:50

And so my strategy was um I'm just going

7:53

to not do anything but work. I'm going

7:55

to uh just work as hard as I can for the

7:58

six years. And um what happens when you

8:00

work and you don't have any sort of life

8:03

outside of work? Uh you gain 25 pounds,

8:05

which is exactly what I did. And you get

8:07

really really stressed. And so I decided

8:10

to go on vacation and I I did a

8:13

adventure river rafting trip in Peru.

8:16

And so I go by myself and you know meet

8:19

other interesting people and um I I was

8:22

the weakest person on this whole trip.

8:24

It was embarrassing. And I came back and

8:26

I said, "Okay, I cannot be the weakest

8:29

person. I'm in my late 30s. I have to do

8:31

something." So I went to the gym. Fast

8:33

forward year and a half, I've lost the

8:36

25 pounds. So proud of myself. So much

8:39

happier. And I'm sitting in my office

8:42

doing what you and I do a lot which is

8:44

writing an NIH grant which is our

8:46

lifeblood right and um writing writing

8:49

writing and this thought goes through my

8:51

mind that had never gone through my mind

8:53

before which was during this six years

8:56

of grant of frantic grant writing when I

8:58

was trying to get tenure and that

9:00

thought was grant writing went well

9:03

today that that felt good but when I

9:06

thought about it I thought it's it's not

9:08

just today my grant writer writing seems

9:11

to have been getting smoother like I'm

9:14

able to focus longer. it the sessions

9:16

feel feel better to me and you know at

9:20

that point the only thing that I changed

9:22

in my life it was a huge thing but I had

9:24

become a gym rat rather than a

9:26

workaholic and that's when my you know

9:30

spidey sense for neuroscientists popped

9:33

up and I said what do we know about the

9:35

effects of exercise on your brain um

9:37

because if I think about it what was

9:40

better about my writing is I could focus

9:42

longer and deeper very important And I

9:45

could remember those little details that

9:48

you try and pull together for your

9:49

million-doll NIH grant from, you know,

9:52

30 different articles that you have open

9:54

on your screen all at the same time.

9:56

That's a hippocample memory. I was

9:58

studying that. I was writing the grants

9:59

on on hippocample memory. And uh so

10:02

that's when I got really interested in

10:06

the effects of exercise on both

10:09

prefrontal focus and attention function

10:11

and hippocample function because of my

10:13

own observation and this kind of I still

10:16

remember where where I was sitting which

10:17

office I was in when I had this

10:19

revelation. But the thing that really

10:21

sealed it for me is right around that

10:24

time um I got a phone call from my mom

10:28

um who said that my dad wasn't feeling

10:31

well and that he had um told her that he

10:35

got lost driving back from the 7-Eleven

10:37

which was literally seven blocks from

10:40

our house that I grew up in. And um I

10:43

knew that was that was hippocample

10:45

function. I suspected dementia. I

10:48

suspected though didn't want to admit

10:50

Alzheimer's dementia which he which he

10:51

had. My dad is the engineer not so

10:55

active all his life but would loved and

10:58

sit sit and read books all day. My mom

11:00

was the athlete. She she played tennis,

11:02

team tennis into her 80s and it started

11:05

to show at that point. I noticed that

11:08

all the things that were improving in my

11:10

brain suddenly went away in my my dad's

11:13

brain and I started thinking this isn't

11:15

just something to help you know somebody

11:17

who wants to get tenure um this is

11:20

something that could help millions and

11:22

millions of people most importantly our

11:25

aging population what if you know what's

11:28

happening and so the thing that makes me

11:31

wake up in the morning is when I

11:33

realized that every single time you move

11:37

your body um you are um releasing a

11:40

whole bunch of neurochemicals and some

11:42

of them we've talked about that the good

11:44

mood comes from dopamine and serotonin

11:46

and neuradrenaline but the thing that

11:48

gets released also particularly with

11:50

aerobic exercise is a growth factor

11:53

called um brain derived neurotrphic

11:56

factor or BDNF and that is so important

11:59

because what it does is it goes directly

12:01

to your hippocampus and it helps brand

12:04

new brain cells grow in in your

12:06

hippocampus. We all have that. Even if

12:08

you're a couch potato, you can get new

12:09

brain cells in your hippocampus to grow.

12:11

But it's like giving your hippocampus a

12:14

um a boost with this regular BDNF if you

12:18

are exercising, which means that we all

12:20

have the capacity to grow a bigger,

12:23

fatter, fluffier hippocampus. And so

12:27

what I like to give people is this image

12:29

of every single time you move your body,

12:31

it's like giving your brain this

12:32

wonderful bubble bath of neurochemicals.

12:35

What's going on? I I need my bubble bath

12:37

of noradrenaline and dopamine and

12:39

serotonin and growth factors. And with

12:43

regular bubble baths, what am I doing?

12:45

I'm growing a big fat fluffy

12:47

hippocampus. And I'm not going to cure

12:50

my father's dementia, Alzheimer's

12:53

dementia. But you know what? If I go

12:55

into my 70s with a big fat fluffy

12:58

hippocampus, even if I had that in my

13:00

genes and it starts to uh kick in, it's

13:03

going to take longer for that disease to

13:05

start to affect my ability to form and

13:07

retain new long-term memories for facts

13:09

and events, which is my motivation for

13:11

getting up and doing my 30 to 45 minutes

13:14

of of aerobic exercise every day.

13:15

>> Tell us your routine. Your routine is 30

13:18

to 45 minutes of are you a Pelaton

13:21

cyclinger? Are you Does it matter? The

13:23

data suggests that as long as your heart

13:25

rate is getting up for these long-term

13:27

effects on your hippocampus and

13:29

prefrontal cortex, you also um get

13:32

better at shifting and focusing your

13:34

attention. Um for that you need

13:37

cardiovascular and what I use is um a

13:40

video workout. They are 30 minutes that

13:42

I sometimes add on a 10 to 15 minute

13:45

stretch at the beginning or at the end.

13:47

But um I love the variety. Sometimes I

13:50

do it with weights, sometimes I do it

13:51

without weights. Uh uh I love

13:53

kickboxing, so they have a lot of

13:54

kickboxing in there. It just fits my um

13:57

fits my fits my routine and it's always

14:00

there and I don't have to get all

14:02

dressed up to go to the gym to uh to to

14:05

work out. So that's that's what I do.

14:07

>> So let's imagine your morning routine.

14:10

You you do your cardiovascular exercise.

14:12

Okay, so you're pumping more blood.

14:14

>> That's the definition of a higher heart

14:15

rate. Stroke volume of the of the of the

14:17

heart goes up over time. You're getting

14:19

fitter. So blood flow to the brain is

14:21

increasing. Do we know

14:23

>> how that gets translated to a signal to

14:26

release more BDNF?

14:27

>> Yeah. Um before I go into the aerobic

14:31

thing, I always like to start with the

14:33

least amount of exercise to get

14:35

something really useful because I don't

14:38

want people to say, "Oh god, I hate, you

14:40

know, sweating. I don't want to listen

14:42

anymore." So, so I always like to start

14:45

with um studies have shown that just 10

14:48

minutes of walking outside can shift

14:51

your mood. That is part of that

14:53

neurochemical bubble bath that you're

14:54

getting. Dopamine, serotonin, nor

14:56

adrenaline. Um and 10 minutes and

14:59

anybody can walk for 10 minutes. Um and

15:02

so that is uh for all of you thinking

15:05

that out there, what is the minimum that

15:07

I could get some of these brain effects?

15:08

10 minutes of walking. That minimum

15:10

amount of movement in your body can get

15:13

you th those mood effects. But what

15:16

about the big fat fluffy hippocampus?

15:19

What about the better performing

15:20

prefrontal cortex? That's where you

15:23

start to need the the cardio cardio

15:25

workout. And from my reading of the

15:28

literature, there haven't been enough

15:29

studies, you know, um, uh, directly

15:32

comparing contrasting kickboxing with

15:35

running with, um, whatever whatever

15:37

other cardio that you need to do. But

15:39

any cardio workout that is done has

15:42

these positive effects. So, I'm going to

15:44

say my interpretation of that is that

15:46

whatever way you get your heart rate up,

15:48

including a power walk, a power walk can

15:51

get your heart rate up, that that is

15:53

beneficial. and what is happening. There

15:56

are two pathways that have been studied

15:58

about how you go from moving your body

16:01

to more BDNF that that neurotrofen

16:04

that's uh that's um increasing the

16:06

growth of new hippocample brain cells.

16:08

The two pathways are the following. One

16:10

is a myioine which is a protein released

16:14

by the muscles. So and not your heart.

16:16

These are strided muscles um in your

16:18

body. And so by running this these were

16:21

studies done in rats on running wheels.

16:24

They showed that the running rats had um

16:27

more of this myioine release the myioine

16:30

past the bloodb brain barrier. So it got

16:33

into the the uh rarified very protected

16:36

bloodstream of inside the brain and that

16:39

myioine stimulated the release of BDNF

16:43

in the brain. That's pathway number one.

16:46

Pathway number two comes through the

16:48

liver. Uh because exercise is a stress

16:52

on generally. Uh how do we know that?

16:54

Well, cortisol is released whenever we

16:56

exercise it. We we need we need uh that

16:59

sugar uh in our blood. And so so that's

17:02

how the physiological um mechanisms

17:04

work. And so um there is a uh ketone um

17:09

beta hydroxybutyrate that we've known

17:12

for a very long time that gets released

17:14

by the liver during exercise. And we

17:17

also know that that particular ketone

17:20

passes that bloodb brain barrier and

17:21

it's another stimulant for BDNF. So kind

17:24

of the final common pathway seems to be

17:27

um BDNF stimulation in the hippocampus.

17:31

Is it the only one? Probably not. But

17:34

that's the one that has been studied

17:35

most most clearly. So it's you know it

17:38

comes from all of our physiological

17:39

systems. Our muscles working our liver

17:42

um responding to the stress of of

17:44

exercise. And what is it doing? It is

17:47

making our uh you know giving more BDNF

17:51

precursors to get into our brain to

17:53

cause the upspike of BDNF um which is

17:56

part of your bubble bath that you're

17:58

getting every time you move.

17:59

>> This issue of new neurons

18:02

>> is one that you hear a lot. you know,

18:03

neurogenesis. You're going to grow new

18:05

neurons, new neurons. And and my

18:07

understanding is that the rodent

18:09

literature is very clear. Running more

18:11

on a wheel can trigger neurogenesis that

18:14

literally that the the birth of new

18:17

neurons and the addition of new neurons

18:18

to the hippocampus. And in humans, I

18:21

think it's been a bit controversial.

18:22

Some people say absolutely yes. Other

18:24

people say absolutely no, there are new

18:26

neurons added to the adult brain. I

18:28

haven't followed that literature down to

18:30

the detail. Um but I do remember one

18:33

study that I don't think is contested

18:36

which is the work of Rusty Gage at the

18:38

Sulk Institute where they actually

18:40

injected a a sort of die type marker

18:43

into the brains of terminally ill humans

18:46

who very graciously offered to have

18:48

their brains removed and dissected after

18:51

death. And in these very in some cases

18:54

very old

18:56

>> terminally ill humans they did see

18:58

evidence for new neurons being born in

19:00

the hippocampus.

19:01

>> Can I trust that idea still? Is that

19:04

generally accepted? Well, so after that

19:07

study, which was quite a while ago, uh

19:10

there are more recent studies, still

19:12

controversial, but um showing and

19:14

demonstrating using even new and better

19:17

techniques than were used in that that

19:19

original Rusty Gage study, which was

19:21

groundbreaking at the time that um that

19:24

suggest and I think show that there are

19:27

new neurons born in adult human brains

19:32

into the ninth decade of life. So they

19:35

not only did this I think those those

19:37

patients were in their 60s then they

19:39

they died of cancer um but but these new

19:42

studies uh looking across the timeline

19:45

can we see because the other thing was

19:47

yeah maybe you have some when you're 20

19:49

but by the time you're older and you

19:51

might need these new neurons you have no

19:53

new neuron growth and so these studies

19:56

seem to uh suggest that yes yes you did

20:00

yes you do and we all do even into old

20:02

age. If you would, could you tell us

20:04

about some of the more specific effects

20:07

of exercise on memory?

20:10

>> Absolutely. Let me start with um kind of

20:13

the immediate effects, acute effects as

20:15

they're called, of exercise on the

20:17

brain. So, this is asking what does a

20:20

one-off exercise session do for your

20:23

brain? And there um uh there are three

20:27

major effects that have been reproduced.

20:29

I've seen it in my lab. Many labs have

20:32

reproduced this. This is usually an

20:33

aerobic type type exercise session. 30

20:37

30 to 45 minutes. What you get is that

20:39

mood boost very very consistent. You get

20:43

um uh you get uh improved prefrontal

20:46

function typically uh tested with a

20:48

stroop uh test which is a test that uh

20:51

asks you to shift and focus your

20:53

attention in specific ways. um it's a

20:56

challenging task and clearly dependent

20:58

on the prefrontal cortex largely and um

21:01

significant improvements in reaction

21:03

time. So your your speed at responding

21:06

often a motor kind of uh but cognitive

21:09

motor response is is improved. one of

21:12

the unpublished studies that I did

21:14

looking at the effects of 30 minutes of

21:18

age appropriate workout um in subjects

21:22

ranging in age from their 20s all the

21:24

way up to their 90s. So what are the um

21:29

the things that I saw most consistently

21:31

irrespective of your age everybody got a

21:35

decreased anxiety and depression and uh

21:38

hostility score which is very important

21:40

you know so it's it's not just

21:42

decreasing your anxiety and depression

21:44

but decreasing your hostility levels

21:46

>> making the world a better place

21:47

>> making the world a better better place

21:50

>> energy the feeling of energy went up and

21:54

um what we found is in the older

21:57

population even more than in the younger

21:59

population. We saw improved performance

22:02

on both stroop and um Ericson flanker

22:05

task which are which is another task

22:07

dependent on um really focusing in on

22:11

different letters and paying attention

22:12

to what letter is being shown. Um so so

22:16

these are consistent effects. How long

22:18

do they last? One of the studies that I

22:20

did publish in my lab showed that the

22:22

immediate effects of exercise lasted up

22:25

to two hours. Unfortunately, that was

22:27

the longest that we last. They were

22:29

still there at 2 hours. Um, so that's,

22:32

you know, that's that's a pretty big

22:34

bang for your buck. That is one 30

22:36

minute.

22:36

>> So, what this tells me is that, um,

22:39

exercising early in the day

22:42

>> may have a special effect,

22:43

>> right? I know there there are moms and

22:46

dads out there and they just say, "Look,

22:48

I have a kid that the kid's more

22:50

important than my doing my exercise."

22:52

So, you will get benefits if you if you

22:55

do it whenever whenever you can. So,

22:57

that's great. More power to you. But

23:00

what all the neuroscience data suggests

23:03

is the best time to do your exercise is

23:06

right before you need to use your brain

23:09

in the most important way that you need

23:11

to use it every day. And so that is why

23:13

the morning for most of us is

23:16

beneficial. That's why I do it in the

23:17

morning. I'm lucky enough to be able to

23:19

do that.

23:19

>> I also want to emphasize I'd love to get

23:21

your thoughts on just memory and memory

23:24

loss in general.

23:25

>> You know, my understanding of the

23:27

literature is that somewhere in our 50s

23:29

or 60s, we start noticing little hiccups

23:32

in memory.

23:33

>> Yeah. But I have to imagine that doing

23:36

the exercise throughout one's entire

23:38

life is going to help offset some of

23:40

this simply because of the BDNF and

23:42

other downstream effects.

23:43

>> Yeah. First, I want to share one of my

23:45

favorite studies, which is a

23:47

longitudinal study um done in Swedish

23:50

women. And this was published in 2018.

23:53

And uh what they did was back in the

23:56

1960s, they found um Swedish women, 300

24:00

Swedish women in their 40s and they

24:03

characterized them as low fit, midFit,

24:05

high fit. Okay? And then 40 years later,

24:08

they came back and found these women.

24:10

let them do live their lives and they

24:12

asked what happened to these women as a

24:14

function of whether they were low fit,

24:16

midFit, high fit in their 40s. They're

24:19

now in their 80s. Um and what they found

24:22

was that um relative to the low fit or

24:26

midFit women, the women that were high

24:29

fit gained nine more years of good

24:34

cognition

24:35

later in life. Now, this is not a

24:39

randomized control study. Um, this is a

24:41

correlational study. But does it agree

24:44

with everything that we've been talking

24:46

about today? Yes. Does it agree with

24:48

this idea that, you know, the women that

24:50

were high fit were giving their brains

24:52

this this bubble bath very, very

24:54

regularly for that entire 40 years and

24:57

that built up their big fat beautiful

24:59

hippocampi. Yes, it does. So, um, that's

25:02

one of my favorite studies.

25:03

>> Yeah. another cause for getting the

25:06

exercise in consistently.

25:08

>> Yes. So, when I jumped into the exercise

25:11

work, um, everybody was studying people

25:14

65 or older because that's when

25:17

cognitive decline begins. And if the

25:19

idea is exercise can help you with your

25:21

cognition, then makes sense. However, I

25:25

thought, well, you know that it's great.

25:28

There's lots of work there. I wanted to

25:30

know what happens in people in their 40s

25:33

and their 50s, maybe even their their

25:36

30s and their 20s. Why? Because that's

25:39

when we as humans are able, ready, will

25:42

willing and able to increase our

25:44

exercise and um gets us set set up to,

25:48

you know, build our brains as we go into

25:50

our 60s. And so um the first study that

25:54

I did looked at low fit participants

25:58

from their 30s to mid-50s. And we wanted

26:03

to ask this question, you know, how much

26:06

exercise do you really need to start

26:07

seeing benefits? Do you see benefits? Or

26:09

maybe you have to wait until you start

26:11

seeing cognitive decline to get

26:13

benefits. That was one of the the

26:14

theories out there. And so that's what I

26:17

wanted to do. And so what we did was

26:19

three months of two to three times a

26:22

week cardio. It was a spin spin class.

26:25

So spin classes are great for cardio.

26:27

And the the comparison group was two to

26:30

three times a week of competitive video

26:33

scrabble. So no heart rate uh change,

26:36

but but they had to come into my lab and

26:38

and be in a group just like they were in

26:40

a group for the for the um um spin

26:42

class.

26:44

uh we tested them cognitively

26:45

cognitively at the beginning of the end

26:47

of the session. What we found was two to

26:50

three times a week of cardio in these

26:53

people. They were low fit which means

26:55

specifically that they were exercising

26:57

less than 30 minutes a week for the

27:00

three months previous to the experiment.

27:02

So they went from that to two to three

27:04

times a week of spin class. And what we

27:07

found was um changes in baseline rates

27:11

of their positive mood states went up

27:13

relative to the video scrabble group. Um

27:16

their uh body image got more positive

27:20

because they were exercising which is

27:21

great. And really important their

27:24

motivation to exercise went up

27:26

significantly compared to the video

27:28

scrabble group which is which is great.

27:31

So the more you exercise the more

27:32

motivated you are to exercise. What

27:35

about cognition? and what changed in the

27:37

cognitive circuits of their brain.

27:39

Number one, we got improved performance

27:41

on the stoop task, but uh we're headed

27:45

towards my favorite structure which is

27:46

the hippocampus. What we found was

27:49

improved performance on both a

27:52

recognition memory task which was a um

27:55

memory encoding task um and uh that is

27:58

can you can you differentiate uh similar

28:03

items that we're asking you to remember

28:05

and an spatial episodic memory task

28:09

where we had them play one of those doom

28:11

like games when they went into this

28:13

spatial maze and they had to do things

28:15

in a virtual city. their performance

28:17

there got better which is very very

28:19

classically dependent on the

28:21

hippocampus. So it was so satisfying to

28:25

to do this study because um uh I've been

28:28

wanting to answer this question. What is

28:31

a minimum amount or doable amount of

28:34

exercise that will get you these

28:36

cognitive benefits? And now I can say in

28:40

30 to 50 year olds that are low fit two

28:43

to three times a week. Is that doable?

28:46

Absolutely. Will it be hard if you're

28:48

low fit? Yeah, it's it's going to be

28:49

challenging, but absolutely doable. This

28:52

is not like you have to become marathon

28:55

runner to get any of these benefits.

28:57

This is you have to start moving your

28:59

body on a regular basis, two to three

29:02

times a week.

29:03

>> How long are those sessions again?

29:04

>> 45 minutes.

29:05

>> 45 minutes.

29:06

>> Yeah. 45 minutes. Uh warm up for 5

29:08

minutes and a cool down for 5 minutes.

29:10

So, it's really 35 minutes. 35 minutes

29:12

of, you know, they're really pushing

29:14

you. Yeah. The second study that I

29:16

wanted to share is part two of that

29:18

study that I just described, which was

29:20

the low fit people. Next, we moved to

29:22

midFit people. Like, what about us? You

29:24

know, we're already exercising. How how

29:27

am I going to benefit from increasing my

29:30

exercise? So, here again, we

29:32

collaborated with a great um spin studio

29:35

that had a whole bunch of midfit people

29:37

that that by our definition were

29:39

exercising um two to three times a week

29:42

on a regular basis. That's great. All

29:44

you people out there that are doing

29:45

that, you should know you're already

29:47

benefiting your brain. But our question

29:49

was, what if we invited them to exercise

29:52

as much as they wanted at the spin

29:54

studio for three months from, you know,

29:57

two to three times all the way up to

29:58

seven times a week. And let's just see

30:00

what happened. And the control group,

30:03

um, we asked them not to change their

30:06

exercise. Um, and so what we ended up

30:09

with was a nice big array of starting

30:14

with midFit people that exercise between

30:17

staying at two to three times a week all

30:18

the way up to seven times a week. And

30:21

the bottom line from that study is every

30:25

drop of sweat counted. That is the more

30:28

you change and you increase your workout

30:30

up to seven times a week, the better

30:33

your mood was. you had lower um lower

30:37

amounts of depression and anxiety,

30:39

higher amounts of good um uh good affect

30:43

and the better your hippocample memory

30:45

was with the more you worked out. Again,

30:48

this was for three months. So, I love

30:51

that too because it gives power to to

30:54

those of us that are, you know,

30:55

regularly exercising and wondering, do I

30:58

really need to I mean, is it really

31:00

going to help me? And the answer is yes.

31:02

I mean not all of us can exercise go to

31:04

a spin class seven times a week but um I

31:08

love the message that our body is

31:10

responsive to that and and you can get

31:13

better hippocample function better

31:15

overall baseline mood a effect with with

31:19

a higher level. So it works for uh the

31:21

midfit uh people as well. What is if any

31:25

the value of affirmation of telling

31:28

yourself something positive about

31:30

yourself or of exercise on not the

31:33

exercise itself but on mood, self-image,

31:37

memory and brain function. Yeah, I

31:39

looked into this because I am also a

31:42

certified exercise instructor and the

31:44

form of exercise that I teach is called

31:46

intensi that it's a form of exercise

31:49

that was developed by this amazing um

31:51

fitness instructor Patricia Moreno. Um

31:54

and she combined physical movements from

31:56

kickbox and dance and yoga and martial

31:59

arts with positive spoken affirmations.

32:02

So each move, if you're punching back

32:03

and forth as you would do in a kickbox

32:05

class, you don't just punch, you say

32:07

something like, "I am strong now," which

32:10

every punch is associated with a word.

32:13

And you know, you you can um create your

32:16

own series of affirmations with the

32:18

moves that you put together. There's

32:20

something about the declaration using

32:22

your own voice of saying things that

32:25

you, you know, don't often say to

32:28

yourself, like, "I'm strong. I'm

32:29

inspired. I believe I will succeed are

32:32

all the kinds of affirmations you say.

32:34

And so I started to look into what was

32:36

known about affirmations. And it was

32:39

clear that there was a literature

32:41

showing that that uh positive

32:43

affirmations, saying them or reading

32:45

them, um could change mood. It really

32:48

gets you into a habit of of saying good

32:53

things about yourself. And then you

32:54

start to remember uh start to realize,

32:56

oh my god, I'm so mean to myself. I I

32:59

have lots of negative thoughts going on

33:02

about about myself in my head and which

33:05

was part of the other reason why I loved

33:07

this this particular form of exercise.

33:10

So what you get in intensate is the mood

33:15

boost from the positive spoken

33:17

affirmations together with all the other

33:20

brain and um a effect boosts that we've

33:23

been talking about for this whole uh

33:25

podcast from the exercise because it's a

33:27

sweaty workout as well. So

33:29

>> interesting. I'd like to touch on

33:32

meditation.

33:33

>> Yeah. Sounds like you've discovered a

33:36

minimum a close to minimum threshold of

33:39

meditation that can really benefit us.

33:40

So um so maybe you tell us about that

33:42

that study.

33:44

>> Very practical study. Um just 10

33:46

minutes, not 30 minutes, not an hour

33:49

meditation. That's too hard. 10 minutes

33:51

guided meditation. A um it's a body

33:54

scan, very basic but easy to follow kind

33:58

of meditation. Uh we looked at cognitive

34:01

effects um before and after this. It was

34:04

eight weeks of daily it was actually

34:07

12minut meditation um 12 minutes of body

34:10

scan meditation and um what we found was

34:14

significant decreases in stress

34:16

response. So we did the strier stress

34:19

test to see how how you responded to a

34:22

unexpected stressful situation. The

34:24

meditators did much better. their mood

34:27

was better and their um their cognitive

34:30

performance was also better.

34:32

>> I know there's so much evidence that

34:34

meditation is beneficial.

34:35

>> Yes.

34:36

>> How do you think it's working or what

34:38

what do you think it's doing?

34:39

>> I think that one of the most important

34:42

things that gets um worked when we are

34:46

doing a simple 10 minute or 12 minute

34:48

body scan um meditation regularly. this

34:51

10 minutes a day, 12 minutes a day is um

34:55

the habit building and the practice of

34:58

focusing on the present moment. I think

35:02

that is very hard for us modern humans

35:05

to do. If you know how to do that, that

35:08

gives you this powerful tool for the

35:10

rest of your day. You're not locked into

35:13

that fearful future thinking that so

35:16

many of us have or that that that uh

35:18

just reliving of the terrible past, but

35:21

you could enjoy enjoy the present

35:24

moment.

35:24

>> Are there any other things besides

35:26

exercise and meditation that you would

35:28

like to see people do in terms of trying

35:30

to increase their powers of attention?

35:32

So I would say the top three uh tools

35:35

that everybody right this minute today

35:39

can use to up their capacity to attend

35:43

where they want to. Uh include exercise

35:46

for the reasons we've talked about. It

35:47

has a direct effect on functioning of

35:49

the prefrontal cortex. Meditation also

35:51

clearing

35:53

improved ability to to focus and and

35:57

particularly focus on the present

35:58

moment. Um and the third has to be

36:01

sleep. It is so important for all core

36:06

cognitive functions uh uh including

36:09

attention, including creativity,

36:11

including uh um just good basic brain

36:14

function. So exercise, meditation, sleep

36:19

can help you learn, retain and perform

36:24

better than if you do not have these

36:27

three things in your life. Wendy, thank

36:29

you so much for your leadership in the

36:32

university system, for your leadership

36:33

in public education, for the decades of

36:36

important work on memory and neural

36:38

circuitry, which uh we've got to learn

36:40

about today as well. Thank you ever so

36:43

much.

36:43

>> Thank you, Andrew. Fun conversation.

Interactive Summary

Dr. Wendy Suzuki, a neuroscientist, delves into the fascinating world of memory and brain function, emphasizing the profound impact of exercise and other lifestyle choices. She explains that memory formation relies on novelty, repetition, association, and emotional resonance, highlighting the hippocampus as a crucial structure not only for long-term memory but also for imagination and broad associations. Dr. Suzuki shares her personal journey, revealing how her own experience with exercise and her father's Alzheimer's diagnosis led her to research the significant link between physical activity and cognitive health. She details how aerobic exercise releases neurochemicals like dopamine and serotonin, alongside Brain-Derived Neurotrophic Factor (BDNF), which promotes the growth of new brain cells in the hippocampus, thereby enhancing memory and protecting against cognitive decline. The discussion also covers the immediate benefits of single exercise sessions, the minimum effective doses of exercise and meditation for cognitive improvements, and the importance of sleep as a third key pillar for optimal attention and brain function.

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