Can a GLP-1 Pill Revive Novo Nordisk? | Prof G Markets
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Today's number,
120 million. That's how many dollars
Alex Co-op spent on a Colorado compound,
which used to be the home of a silent
monk community. Palunteer Investor
relations say they support the
transaction, but have requested that the
vow of silence be made transferable.
Welcome to Profy Markets. I'm Edson. It
is January 7th. Let's check in on
yesterday's market vitals. The major
indices all posted strong gains. The Dow
notched its first close above 49,000.
The S&P 500 also hit a record closing
high. Meanwhile, oil prices gave up
Monday's advance. And finally, gold,
silver, and copper extended their
rallies. Okay, what else is happening?
The biggest celebration of consumer
tech, the Consumer Electronics Show or
CES, kicked off in Las Vegas this week.
It is an opportunity for tech companies
to showcase their latest innovations.
And so far, it is Nvidia that is
dominating the headlines. Nvidia's CEO,
Jensen Huang, opened the event with an
announcement that their most advanced
chip yet, the Reuben model, is in full
production. He also introduced AI models
for autonomous vehicles. and he said,
quote, "The chat GBT moment for physical
AI is here, and it appears to be
happening fast because Mercedes-Benz
will begin shipping cars with Nvidia's
technology this year." So, lots
happening at CES. We wanted to get a
sense of what else is happening. So, we
are speaking with someone who was there
right now, Alex Heath, author of the
Sources Newsletter and host of the
Access podcast, joins us from Vegas.
Alex, welcome back and happy new year.
Happy new year, Ed. I am doing CS like I
always do, which is I try to avoid the
show floor as much as possible, but uh I
am managing to head over there right
after this conversation. But I've I've
gotten a good lay of the land from the
hotel rooms and restaurants where all
these meetings are happening, which I
it's actually like the shadow CS. It's
this like the second show that happens
at all the hotels on the strips that I
on the strip that I find to be much more
interesting. But yeah,
>> I I've never been to CES. For those who
like don't know what it is, what what is
it? What's going on over there?
>> I mean, it started as the place where
Apple and all these companies would show
off their new, you know, hardware and
gadgets, right? And then all the tech
companies got big and started doing
their own events. And I would say in the
last decade especially, it's been more
regulated to a lot of companies outside
of the US that see as an opportunity to
kind of make a splash here uh in in
North America to start the year and a
bunch of smaller startups uh and a lot
of vapor wear and a lot of bloware uh
and stuff that will never ship or never
never see the light of day. Um but you
know if you squint you can see real
things. It's just gets increasingly
harder to do that every year is my my
experience.
>> So far, what are the real things that
you've seen? We're seeing headlines over
here about what Nvidia is doing,
>> uh, specifically their Reuben chip and
the, um, the plans with AI enabled
cores. That's what I'm seeing here in
New York. What are you seeing? What's
real at CES right now?
>> Apparently, the Nvidia autonomy thing is
real. I mean, they're shipping uh Jensen
said on stage yesterday uh Monday to
kick things off that uh they'll be
shipping with Mercedes and Q1 in the US.
I'm not sure how big of a pilot that is
actually, but I I would say that was the
thing that a lot of people were buzzing
about around all the cocktail parties uh
in the evening after Jensen's keynote
was it are you know is Nvidia going
really for Tesla and full self-driving
and competing with Elon? who is a one of
if not you know top three or four
biggest Nvidia customers of of GPUs
right and the read I got was actually
that uh Nvidia doesn't see autonomy as a
business for itself in its own right
necessarily right because they're open
sourcing the underlying model they're
wanting it to be a little bit more of
like an Android type approach where they
work with a lot of different uh car
manufacturers
I think it's a way for them to get data
which Jensen talked out a lot on stage
and inform the way that they build
future chips for their customers. I
think they do things like autonomy or
robotics, not because they see those
verticals as a business akin to selling
GPUs, but because the more specialized
and vertical they go in certain domains,
the more they learn and it's a flywheel
that then informs the way that they
develop their bread and butter. And I
think that's a thing about them that
maybe is not more broadly understood,
but I was just hearing from Nvidia
employees and other people in in the AV
space last night is that uh they're not
actually coming for you know Whimo's
launch here. Uh and I thought that was
pretty interesting.
>> Yeah, that is interesting. And you know,
look at the stock Nvidia's stock today
which is basically flat actually kind
slightly down. And I don't know if
that's anything to do with what's been
said at CES, probably not. But what
we're basically seeing is that they've
come out with this pretty big deal news
announcement, at least as an observer. I
mean, the video of a Mercedes driving
around on Nvidia's AI seems like a big
deal, but the market appears to be
either already pricing that in or it's
not that interested. Um,
>> maybe the market understands what I was
saying, just that it's not it's not
going to be a big business for them. uh
and that it's also early, right? And
they're they are behind Tesla
tremendously in terms of like the data
that that FSD has and all of the miles
that Teslas have driven uh which Elon
was quick to jump in and point out on X
I saw after the keynote. The only other
real fun piece of gossip here after day
one at CS is uh the timing of that
Jensen keynote and I don't know if you
got to watch the whole thing. It was
unusually rushed feeling, unusually like
um I don't know, there were like
technical difficulties. He had to stop
and start. Um it wasn't as polished as
he normally is. Uh and the rumor here in
Vegas is that that whole thing was very
hastily thrown together to upstage AMD,
his uh I believe cousin Lisa Sue, right?
Uh of AMD, who was doing the actual
CEO's uh the actual mainstage CS keynote
later that evening. And so you'll notice
like Nvidia wasn't on the official CS
stage. They were doing their own thing
at at the phones and blue. Uh and he did
the official keynote I believe last year
to kick things off. And like you know
Lisa is doing it this year and AMD is
kind of having a moment. She brought out
Greg Brockman from OpenAI. And I think
they wanted I think there's still that
super competitive dynamic and he wanted
to upstage her as is the fun gossip out
here. Based on what you've seen so far,
would you say that there is a an
overarching theme to the pitches and the
presentations that we're seeing right
now? I would assume last year it was AI.
I'm sure it's still kind of AI this
year, but but if you could sort of
describe what the theme is, what are
people aligned on? a lot of AI
wearables, a lot of like rings that you
talk to and leave, you know, voice notes
into. Uh, AI glasses, display glasses.
Meta is here in a pretty big way talking
about their glasses. A lot of robotics,
most of which to me looks like
vaporware. Most, you know, it wouldn't
be CS without all these, you know, demos
of humanoids like doing things in
kitchens or whatever. And like I've seen
that so many times that it just kind of
I'm numb to it. And until I start seeing
these robots like out in the real world,
I just don't believe it. Uh, and so
there's a lot more of that this year,
people seem to I mean Jensen was saying
this in the keynote. I think he said
like the chat GPT moment for physical AI
is coming. He's been saying that for a
while. It does feel like things because
of how good the models are getting that
things are starting to converge and
maybe we will actually see a real kind
of robotics even humanoid type moment. I
don't know if it's going to be this
year, but there's a lot of companies
here showing that off, at least the
demos of it. The only other big thing
and this is happening when we're
recording on Tuesday later tonight is
Lenovo is uh here in a very big way
which the number one PC uh maker in the
world and they've not really had a big
CS presence and they're a pretty low-key
company but you know we've got hundreds
of millions of devices and uh they are
taking over the sphere and announcing
this big you know AI product offering
for all of their PCs that chains
together a lot of different AIs and
partners like a notion or perplexity
whatever to create this proactive more
natural language contextaware AI on your
PC. Um, and so a lot of people focusing
on how do we take AI out of the chatbot
and actually put it into either your PC,
your wearable, your car, a robot, and
make it a little more useful than just
talking to a chatbot.
>> Yeah, just slightly pivoting here. Um,
something that happened while we were
gone for break that we haven't been able
to cover which I want to bring up to you
now is this deal between Nvidia and
Grock, this chip startup. Nvidia bought
the company for $20 billion, its biggest
purchase ever.
>> Fake bought it.
>> Fake bought it. So that's the other side
to this. They frame it as a a deal, this
licensing agreement. It looks a lot like
a acquisition to me, I guess. Please
take it away. what is actually going on
here?
>> I call these reverse aqua hires and I'm
glad that the name has actually stuck
since I coined it about a year and a
half ago. But it's these thing, it's
this stuff that big, you know, the big
tech players are doing where they take
the key talent from a lab, do a
non-exclusive IP license for the tech
because they don't actually care about
the tech, they care about the talent,
uh, and leave the kind of flaming husk,
if you will, of like the thing left
behind. And I think Grock's in a little
bit of a different spot because they
have a pretty fast growing um lucrative
cloud AI inference business that they're
going to continue to run and they've got
a ton of GPUs and I think they'll have a
lot of in inbound there cuz there is
just still so much demand for that. But
yeah, Jonathan Ross the founder and his
kind of core technical team going over
to Nvidia to you know from my
understanding address what Nvidia sees
as a huge issue which is you know it's
it's GPUs are very good for training but
AI inference which is running AI in the
real world in production right so when
you prompt chat GBT that is doing AI
inference uh they they're behind there
their latency is not very good um
there's all these startups like Grock
was spinning up to take that market and
the workloads are moving to inference
they're moving to production all the
things we were just talking about,
Lenovo, the robots, that's all
inference. And so I think they see that
as the next major wave for their
business. And Jonathan and the team
there will help them fix those issues
with latency for for inference. But
yeah, that deal is super unusual
unusual. I mean, I I reported in sources
it happened in under 10 days. Uh Jensen
wired the money early. He wanted it done
before the new year, probably for tax
reasons or something or maybe because he
was just antsy. I don't know.
uh and uh went from like really not
knowing Jonathan, the founder of Grock
at all to doing the deal in like a
matter of just a few months. So Jensen
is in founder mode 100%. And when you
look at all the cash that Nvidia has on
its balance sheet and the rumors about
them looking at other deals, I expect
this is just the beginning. I expect
they'll keep doing deals. Maybe not 20
billion, but I think they'll keep doing
big deals.
>> So interesting that we keep seeing this
theme that there is exactly you say the
reverse aqua hire theme. Um, I mean,
just thinking back to Microsoft and and
Inflection where the same thing
happened, um, and they have this deal
and then all of the talent goes over to
Microsoft and then what do you know? The
founder of Inflection is now the CEO of
Microsoft AI. And I assume something
similar is going to happen with Jonathan
Ross. Something so interesting that you
reported is that he told you that they
had no intention of being acquired. He
said, I read the quote that you
reported. He said to you, quote, "We
have no intention of being fake acquired
or real acquired for that matter." He
literally predicted precisely the
opposite of what happened.
>> Yeah.
>> What do you make of that?
>> I mean, I love it. You know, if a
founder tells me something like that and
I have the ability to remember, that's
the thing. I was like, it's harder to
remember these days. But when I
remember, oh, I had this conversation,
they said that, I dig it up. And yeah,
this was
>> over a year ago. You know, it was
actually the same day that Google
reverse Aqua hired Character AI, which
was something people have probably
forgotten about by now, but was another
one of these multi-billion dollar deals.
And um yeah, I asked him about it in the
interview that day and he was like,
"Yeah, we're not going to be fake
acquired." And then you know what? Uh I
$20 billion had something different, you
know, to say about that. I guess
everyone has their price, right?
>> Exactly. It seems like this this
continues to be the theme where as the
founder of an AI company, you're saying
we're going to take over the world.
We're going to take on big tech. we can
do it ourselves. And then someone shows
up with a ridiculously large bag of
money at which point you kind of shut
the [ __ ] up and take the money and you
go home.
>> I mean, we were talking about all this
just we were talking about all these,
you know, AI researcher comp packages
over the summer, right? With which Meta
was doing. Jonathan, the founder of
Grock, is probably considered top three
to five greatest minds in the world on
on chips. He's the only he invented the
TPU at Google. Uh he's invented the
Grock chip and now he's working at
Nvidia. So he's one of the only leaders
to have touched all kind of three major
major chips and uh I think he's for
Nvidia that's worth it.
>> Yeah. Um just final uh question before
you go. It's a new year 2026. If you had
to make predictions about what we will
see in the tech sector maybe like the
technology of the year. It sounds like
robotics is getting a lot of attention
>> uh at CES, but maybe it sounds like you
don't believe it it's going to really
come to fruition. What would be your
predictions for uh technology in 2026?
On the hardware side, I think AI
wearables we're only going to keep
hearing more about. I think we're
getting that here at CES. It's going to
start trickling out more. I think we
maybe will see a tease from OpenAI what
they've been up to with Johnny IV maybe
by the end of the year. And yeah, I
think Meta will ship stuff. Apple will
maybe tease stuff. Uh Snap will release
their glasses, the consumer version.
>> I do think that's on the hardware side.
That's the biggest thing I'm looking at.
And also all these like AI rings and
pendants and that's just everywhere here
at CES and I expect that to only get
bigger.
>> Okay, Alex Heath, appreciate your time.
Enjoy Vegas. And don't do too much
gambling. I know you love I know you're
a gambling man.
>> I'll be at room later tonight. Yeah, you
know me.
>> I love it. Okay, thanks Alex.
>> Thanks.
>> We'll be right back. And if you're
enjoying the show so far, be sure to
like and subscribe to the Prof Pod
YouTube channel at the link below.
We're back with Profy Markets.
Nova Nordisk launched the first ever
GLP1 pill this week, marking a new
chapter for obesity treatment in the US.
The Wiggoi pill is available now and it
costs between $149 and $299 per month,
which is a fraction of the price of
injectables. The company says that the
combination of lower pricing and easier
dosing could open new possibilities for
more than 100 million Americans living
with obesity. The stock is up 5% since
that announcement. To help us break down
what this means for Nova Nordisk, we're
speaking with Jared Holtz, healthcare
equity strategist at Mizuo. Jared,
thanks for joining us on Profit Markets.
>> Great to be here. Thanks a lot.
>> So, this GLP1 pill
uh has been launched by Novon Nordisk.
You can buy it today. Uh seems like
quite a significant development. Let's
just start with your initial reactions
to this move. Yeah, for sure. I've been
keeping a really close eye on on the
development of the oral pills for
obesity just given the fact that the
category the broader GLP-1 category is
expected to be north of 100 billion,
right? And and we know that the orals
are going to have a big piece of that. I
think when you go back and you kind of
consider some of the data sets that
we've seen out of Nova Nordisk, out of
Eli Lilly and others, it's been spotty
at times for the pill because the the
mechanism or the delivery is a little
bit different and we already have
awesome drugs on the market. So, it's
tough to know exactly where these are
going to fit, but it's a consumer
product at the end of the day, right? So
by virtue of that, the market is going
to be massive even if the drugs aren't
that great, I think.
>> Yeah. What are the differences between
the pill and the needle besides the
delivery? Is is the pill less effective?
Does it work differently in the body?
What's the difference?
>> I think the main thing is that the
halflife of the pill is so different
than the injectable, right? When you
take the the once weekly injectable,
you're looking at at a product that is
incredibly efficacious for most of that
week. And at the the back end of that
week, sometimes the effect waines a
little bit and patients that are on the
product get a little bit hungrier and
their side effects actually dissipate,
which is good and bad. And then when you
take it again, you kind of restart the
cycle. here when you're taking these
pills every day. I think there there's a
there's an issue here with can your body
absorb enough on any given day to kind
of really do the same um have the same
effect as the injection from an efficacy
standpoint without having the detriment
of side effects. because some of the
side effects that we've seen in the
pills have been worse, but we also
haven't really seen what a real life
patient may experience, which is to say
taking very small doses for a while
before then titrating up to higher
doses. We we really haven't seen a trial
run, I don't think, by any company
that's ideal or really will mirror what
we see in real life, which are patients
probably either opting to take the pill
because they're not that heavy and they
don't need a high dose or that have
already lost a lot of weight by taking a
drug from Novo or from Lily and kind of
just want to stabilize their w their
weight. We don't really know how this is
all going to work out, but there are
tens of millions of patients out there
that are that are kind of like in the
addressable market here. So, it I'm not
really sure it matters.
>> Yeah. Yeah. The the pricing is quite
interesting, too. Uh between 149 and 299
per month. Uh that's a fraction of the
price of the uh injectable. Uh what do
you make of that pricing? Well, the
injectable prices are coming down too.
So, I think in 6 months, 12 months, the
there might be a little bit more par.
Um, I think that the pricing allows
patients to get on it, especially those
that are going to have to pay out of
pocket, right? And that that's the
biggest piece of this is are do we do we
think that all of the patients that are
eligible are are going to get insured
for it? Likely not. But if your doctor
is willing to write a prescription for
it, even if you're not covered, for less
than 200 a month, you can get access. By
the way, the price of gyms in the United
States is well north of that for decent
ones, right? There are there are crappy
gyms that you can that you can uh go to
monthly for for less, but the good ones
are a lot more. So, if your if your
whole objective is to sort of just lose
10 lb, 20 lb, I think these injectables
are going to be, you know, very
significant really quickly. And that's
why I think it's super interesting for
Novo to be in this spot.
>> What do you think of the competition
that we're seeing in the oral uh GLP1
space? Eli Liy, for example, I know is
working on their own pill. What is the
competitive landscape look like? And
what do you think this means for Novo
Nordisk shareholders compared to say Eli
Liy shareholders? Well, it's really
interesting because when you look at
both when you look at the stocks
specifically, the expectations around
Lily's Oral or for Gibron and then the
oral we go out of Nova Nordis, the the
chasm between the two couldn't be
bigger, right? You've got one company
that's north of a trillion dollars in
market cap predicated mainly on their
GLP-1 drugs, whether it's the oral or or
the injectable and and obviously they
have a lot more in their portfolio, but
the stock movements on the back of
obesity have been the most pronounced by
far. Then you've got Novo Nordisk, which
is, you know, as of two weeks ago was
trading close to a 5-year low. So the
expectation gain between the two is so
pronounced as though no one thinks that
this oral we go is going to do anything
but or for glyip run is going to be
incredibly successful. So it's got to I
think it's going to be much more similar
than different and I think the data sets
are actually from an efficacy and safety
standpoint not that different either.
When the when the Lily data first came
out investors weren't that excited about
it. The stock dropped about 15 to 20%.
And then over time as the company kind
of explained how the trial worked and
the design and and how they put patients
on the drug, we we all became more
comfortable. But I think the
expectations around Novo specifically
are really really low. And I think
that's good. That's good for the stock.
>> Yeah. Yeah. Absolutely. I mean this and
this will be the final question. The
we've seen the hype cycle of the GLP1
industry kind of run its course. it sort
of hit that peak and then suddenly
people kind of went, "Oh, maybe this
isn't going to happen the way we thought
it would." Um, and it sort of waned
again and it's definitely reflected in
the stock price of Nova Nordisk. Do you
think that we could be in for a reversal
again? Are we about to maybe hit another
phase of interest and excitement for
this industry?
>> Yeah, I I don't really know where we are
in the cycle. I mean I it felt like
midway through last year the the waning
aspect that you talked about was right
and then as we got further in the year
with or forgi data Lily hitting a
trillion in cap metah getting acquired
by fizer in that bidding war which was
very strange and then the structure data
at the end of the year. I think we're
we're still in a pocket where I think
there's a lot of excitement. But what
could get excitement for Novo
specifically would be if the Oro GOI
started to take off and the market share
disparity between it and Lily kind of
compress us a little bit. That's what's
really going to take Novo up.
>> Okay. Jared Holtz, healthcare equity
strategist at Mizuo. Jared, really
appreciate your time.
>> Great to be with you. Thanks a lot.
Well, GLP-1 drugs have come a long way
since they were first introduced,
believe it or not, in 2005. It was
originally intended to treat diabetes
and then we learned it could treat
obesity too. Then Ompic came along, then
Wiggoi, then Munjaro, then Zepbound and
now we have reached a point at which 1
in 8 Americans currently use GLP1. So
that is more than 40 million people.
It's more than the population of Canada.
Now, many people have said that we might
have hit peak GLP1, that yes, GLP1s
might be a big deal, but maybe they're
not as big a deal as we once thought.
However, we believe that this story is
actually just getting started. Because
our view is that despite the incredible
adoption we've seen over the past few
years, the reality is GLP1 still face
significant barriers to entry. And of
those barriers, one of the biggest is
the fact that in order to take it, you
have to stick a needle in your leg. Now,
for some people that might not be a big
deal, but for many people it is a big
deal. In fact, it is a big deal for most
people. It turns out 63% of adults say
they experience some level of needle
phobia, i.e. they hate needles. And of
those needle phobes, more than half say
that they will actively avoid having
their blood drawn because of needles.
Meanwhile, roughly a third of them say
they actively avoid getting vaccinated
because of needles. So if a third of the
entire adult population isn't getting
their blood drawn because they're scared
of needles, well then the obvious
question is what percentage of the
population isn't taking GLP-1 drugs for
the same reason? Is it also a third? Is
it half? Is it higher than half? What we
have here is a seemingly small and
uninteresting issue, which is in fact a
pretty gigantic issue. And as of this
week, with the release of this new pill,
that issue has been eliminated. You can
now take a drug that helps you lose
dramatic amounts of weight. And it is
functionally no different from popping
an Advil. That is a really big deal. And
when you live in a country where 40% of
the population is already obese, you
have to think that that 1 in8 number is
about to go way higher. Now, to be
clear, Nova Nordisk isn't the only
winner here. As we've discussed, Eli Liy
is also getting approval for their
weight loss pill, which will likely
launch in the next few months or so.
There are also plenty of Chinese
companies that are working on their own
GLP-1 pill. that this is becoming a
crowded space and our point here isn't
to just go and buy Nova Nordisk. No, our
point is a lot broader than that. Our
point is that GLP1s are just getting
started right now. Or at least that is
our thesis. And now that this pill is
out, now that it is readily available
across the US, that thesis will be put
to the test.
Thanks for listening to Profit Markets
from Profit Media. If you liked what you
heard, subscribe to our YouTube channel
and tune in tomorrow for more.
Ask follow-up questions or revisit key timestamps.
The video discusses major market activities and highlights from the Consumer Electronics Show (CES) in Las Vegas. Nvidia dominated CES headlines with its new Reuben chip and AI models for autonomous vehicles, strategically using these ventures for data to inform future chip development. A significant trend discussed is the 'reverse acquihire,' exemplified by Nvidia's $20 billion deal with Groq, primarily to acquire top talent like Jonathan Ross to address AI inference issues. Predictions for 2026 tech emphasize the rise of AI wearables. The second half of the video focuses on Nova Nordisk's launch of the first GLP-1 pill for obesity, priced significantly lower than injectables. This development aims to overcome needle phobia, a major barrier, and expand market access, signaling that the GLP-1 market is just beginning despite existing competition from companies like Eli Lilly.
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