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Can a GLP-1 Pill Revive Novo Nordisk? | Prof G Markets

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701 segments

0:00

Today's number,

0:02

120 million. That's how many dollars

0:05

Alex Co-op spent on a Colorado compound,

0:08

which used to be the home of a silent

0:10

monk community. Palunteer Investor

0:13

relations say they support the

0:14

transaction, but have requested that the

0:16

vow of silence be made transferable.

0:24

Welcome to Profy Markets. I'm Edson. It

0:26

is January 7th. Let's check in on

0:28

yesterday's market vitals. The major

0:30

indices all posted strong gains. The Dow

0:33

notched its first close above 49,000.

0:36

The S&P 500 also hit a record closing

0:39

high. Meanwhile, oil prices gave up

0:42

Monday's advance. And finally, gold,

0:44

silver, and copper extended their

0:46

rallies. Okay, what else is happening?

0:51

The biggest celebration of consumer

0:54

tech, the Consumer Electronics Show or

0:56

CES, kicked off in Las Vegas this week.

0:59

It is an opportunity for tech companies

1:01

to showcase their latest innovations.

1:04

And so far, it is Nvidia that is

1:06

dominating the headlines. Nvidia's CEO,

1:10

Jensen Huang, opened the event with an

1:11

announcement that their most advanced

1:13

chip yet, the Reuben model, is in full

1:15

production. He also introduced AI models

1:18

for autonomous vehicles. and he said,

1:20

quote, "The chat GBT moment for physical

1:23

AI is here, and it appears to be

1:25

happening fast because Mercedes-Benz

1:28

will begin shipping cars with Nvidia's

1:30

technology this year." So, lots

1:32

happening at CES. We wanted to get a

1:34

sense of what else is happening. So, we

1:36

are speaking with someone who was there

1:38

right now, Alex Heath, author of the

1:40

Sources Newsletter and host of the

1:42

Access podcast, joins us from Vegas.

1:45

Alex, welcome back and happy new year.

1:48

Happy new year, Ed. I am doing CS like I

1:51

always do, which is I try to avoid the

1:53

show floor as much as possible, but uh I

1:57

am managing to head over there right

1:59

after this conversation. But I've I've

2:00

gotten a good lay of the land from the

2:03

hotel rooms and restaurants where all

2:05

these meetings are happening, which I

2:06

it's actually like the shadow CS. It's

2:09

this like the second show that happens

2:11

at all the hotels on the strips that I

2:13

on the strip that I find to be much more

2:15

interesting. But yeah,

2:16

>> I I've never been to CES. For those who

2:18

like don't know what it is, what what is

2:20

it? What's going on over there?

2:22

>> I mean, it started as the place where

2:25

Apple and all these companies would show

2:28

off their new, you know, hardware and

2:30

gadgets, right? And then all the tech

2:32

companies got big and started doing

2:35

their own events. And I would say in the

2:36

last decade especially, it's been more

2:39

regulated to a lot of companies outside

2:42

of the US that see as an opportunity to

2:44

kind of make a splash here uh in in

2:46

North America to start the year and a

2:49

bunch of smaller startups uh and a lot

2:51

of vapor wear and a lot of bloware uh

2:54

and stuff that will never ship or never

2:56

never see the light of day. Um but you

2:58

know if you squint you can see real

3:01

things. It's just gets increasingly

3:02

harder to do that every year is my my

3:04

experience.

3:05

>> So far, what are the real things that

3:08

you've seen? We're seeing headlines over

3:10

here about what Nvidia is doing,

3:13

>> uh, specifically their Reuben chip and

3:15

the, um, the plans with AI enabled

3:19

cores. That's what I'm seeing here in

3:21

New York. What are you seeing? What's

3:23

real at CES right now?

3:25

>> Apparently, the Nvidia autonomy thing is

3:27

real. I mean, they're shipping uh Jensen

3:29

said on stage yesterday uh Monday to

3:32

kick things off that uh they'll be

3:34

shipping with Mercedes and Q1 in the US.

3:36

I'm not sure how big of a pilot that is

3:39

actually, but I I would say that was the

3:42

thing that a lot of people were buzzing

3:44

about around all the cocktail parties uh

3:47

in the evening after Jensen's keynote

3:49

was it are you know is Nvidia going

3:54

really for Tesla and full self-driving

3:56

and competing with Elon? who is a one of

3:59

if not you know top three or four

4:01

biggest Nvidia customers of of GPUs

4:03

right and the read I got was actually

4:05

that uh Nvidia doesn't see autonomy as a

4:09

business for itself in its own right

4:11

necessarily right because they're open

4:13

sourcing the underlying model they're

4:16

wanting it to be a little bit more of

4:17

like an Android type approach where they

4:19

work with a lot of different uh car

4:20

manufacturers

4:22

I think it's a way for them to get data

4:26

which Jensen talked out a lot on stage

4:28

and inform the way that they build

4:30

future chips for their customers. I

4:33

think they do things like autonomy or

4:35

robotics, not because they see those

4:37

verticals as a business akin to selling

4:40

GPUs, but because the more specialized

4:43

and vertical they go in certain domains,

4:44

the more they learn and it's a flywheel

4:46

that then informs the way that they

4:49

develop their bread and butter. And I

4:51

think that's a thing about them that

4:52

maybe is not more broadly understood,

4:54

but I was just hearing from Nvidia

4:56

employees and other people in in the AV

4:59

space last night is that uh they're not

5:02

actually coming for you know Whimo's

5:04

launch here. Uh and I thought that was

5:06

pretty interesting.

5:07

>> Yeah, that is interesting. And you know,

5:10

look at the stock Nvidia's stock today

5:12

which is basically flat actually kind

5:14

slightly down. And I don't know if

5:16

that's anything to do with what's been

5:18

said at CES, probably not. But what

5:22

we're basically seeing is that they've

5:23

come out with this pretty big deal news

5:26

announcement, at least as an observer. I

5:29

mean, the video of a Mercedes driving

5:32

around on Nvidia's AI seems like a big

5:35

deal, but the market appears to be

5:39

either already pricing that in or it's

5:41

not that interested. Um,

5:43

>> maybe the market understands what I was

5:44

saying, just that it's not it's not

5:46

going to be a big business for them. uh

5:48

and that it's also early, right? And

5:50

they're they are behind Tesla

5:52

tremendously in terms of like the data

5:53

that that FSD has and all of the miles

5:56

that Teslas have driven uh which Elon

5:59

was quick to jump in and point out on X

6:01

I saw after the keynote. The only other

6:03

real fun piece of gossip here after day

6:04

one at CS is uh the timing of that

6:08

Jensen keynote and I don't know if you

6:09

got to watch the whole thing. It was

6:11

unusually rushed feeling, unusually like

6:15

um I don't know, there were like

6:17

technical difficulties. He had to stop

6:18

and start. Um it wasn't as polished as

6:22

he normally is. Uh and the rumor here in

6:25

Vegas is that that whole thing was very

6:27

hastily thrown together to upstage AMD,

6:30

his uh I believe cousin Lisa Sue, right?

6:33

Uh of AMD, who was doing the actual

6:36

CEO's uh the actual mainstage CS keynote

6:39

later that evening. And so you'll notice

6:41

like Nvidia wasn't on the official CS

6:43

stage. They were doing their own thing

6:44

at at the phones and blue. Uh and he did

6:46

the official keynote I believe last year

6:48

to kick things off. And like you know

6:50

Lisa is doing it this year and AMD is

6:51

kind of having a moment. She brought out

6:52

Greg Brockman from OpenAI. And I think

6:55

they wanted I think there's still that

6:57

super competitive dynamic and he wanted

6:58

to upstage her as is the fun gossip out

7:01

here. Based on what you've seen so far,

7:03

would you say that there is a an

7:06

overarching theme to the pitches and the

7:09

presentations that we're seeing right

7:10

now? I would assume last year it was AI.

7:14

I'm sure it's still kind of AI this

7:16

year, but but if you could sort of

7:18

describe what the theme is, what are

7:21

people aligned on? a lot of AI

7:24

wearables, a lot of like rings that you

7:27

talk to and leave, you know, voice notes

7:30

into. Uh, AI glasses, display glasses.

7:33

Meta is here in a pretty big way talking

7:35

about their glasses. A lot of robotics,

7:38

most of which to me looks like

7:39

vaporware. Most, you know, it wouldn't

7:42

be CS without all these, you know, demos

7:44

of humanoids like doing things in

7:46

kitchens or whatever. And like I've seen

7:47

that so many times that it just kind of

7:49

I'm numb to it. And until I start seeing

7:52

these robots like out in the real world,

7:53

I just don't believe it. Uh, and so

7:56

there's a lot more of that this year,

7:58

people seem to I mean Jensen was saying

8:00

this in the keynote. I think he said

8:02

like the chat GPT moment for physical AI

8:04

is coming. He's been saying that for a

8:06

while. It does feel like things because

8:08

of how good the models are getting that

8:10

things are starting to converge and

8:11

maybe we will actually see a real kind

8:13

of robotics even humanoid type moment. I

8:16

don't know if it's going to be this

8:17

year, but there's a lot of companies

8:18

here showing that off, at least the

8:20

demos of it. The only other big thing

8:22

and this is happening when we're

8:23

recording on Tuesday later tonight is

8:25

Lenovo is uh here in a very big way

8:27

which the number one PC uh maker in the

8:31

world and they've not really had a big

8:33

CS presence and they're a pretty low-key

8:35

company but you know we've got hundreds

8:36

of millions of devices and uh they are

8:40

taking over the sphere and announcing

8:41

this big you know AI product offering

8:44

for all of their PCs that chains

8:47

together a lot of different AIs and

8:48

partners like a notion or perplexity

8:50

whatever to create this proactive more

8:53

natural language contextaware AI on your

8:56

PC. Um, and so a lot of people focusing

8:59

on how do we take AI out of the chatbot

9:02

and actually put it into either your PC,

9:05

your wearable, your car, a robot, and

9:07

make it a little more useful than just

9:09

talking to a chatbot.

9:10

>> Yeah, just slightly pivoting here. Um,

9:13

something that happened while we were

9:15

gone for break that we haven't been able

9:17

to cover which I want to bring up to you

9:18

now is this deal between Nvidia and

9:21

Grock, this chip startup. Nvidia bought

9:24

the company for $20 billion, its biggest

9:28

purchase ever.

9:28

>> Fake bought it.

9:30

>> Fake bought it. So that's the other side

9:32

to this. They frame it as a a deal, this

9:36

licensing agreement. It looks a lot like

9:38

a acquisition to me, I guess. Please

9:42

take it away. what is actually going on

9:43

here?

9:44

>> I call these reverse aqua hires and I'm

9:46

glad that the name has actually stuck

9:47

since I coined it about a year and a

9:49

half ago. But it's these thing, it's

9:50

this stuff that big, you know, the big

9:52

tech players are doing where they take

9:54

the key talent from a lab, do a

9:55

non-exclusive IP license for the tech

9:57

because they don't actually care about

9:58

the tech, they care about the talent,

10:00

uh, and leave the kind of flaming husk,

10:03

if you will, of like the thing left

10:04

behind. And I think Grock's in a little

10:06

bit of a different spot because they

10:07

have a pretty fast growing um lucrative

10:11

cloud AI inference business that they're

10:13

going to continue to run and they've got

10:14

a ton of GPUs and I think they'll have a

10:17

lot of in inbound there cuz there is

10:19

just still so much demand for that. But

10:21

yeah, Jonathan Ross the founder and his

10:23

kind of core technical team going over

10:24

to Nvidia to you know from my

10:26

understanding address what Nvidia sees

10:29

as a huge issue which is you know it's

10:31

it's GPUs are very good for training but

10:33

AI inference which is running AI in the

10:36

real world in production right so when

10:37

you prompt chat GBT that is doing AI

10:40

inference uh they they're behind there

10:42

their latency is not very good um

10:44

there's all these startups like Grock

10:46

was spinning up to take that market and

10:48

the workloads are moving to inference

10:50

they're moving to production all the

10:51

things we were just talking about,

10:52

Lenovo, the robots, that's all

10:54

inference. And so I think they see that

10:56

as the next major wave for their

10:58

business. And Jonathan and the team

11:00

there will help them fix those issues

11:02

with latency for for inference. But

11:04

yeah, that deal is super unusual

11:05

unusual. I mean, I I reported in sources

11:08

it happened in under 10 days. Uh Jensen

11:11

wired the money early. He wanted it done

11:13

before the new year, probably for tax

11:14

reasons or something or maybe because he

11:16

was just antsy. I don't know.

11:18

uh and uh went from like really not

11:21

knowing Jonathan, the founder of Grock

11:22

at all to doing the deal in like a

11:24

matter of just a few months. So Jensen

11:26

is in founder mode 100%. And when you

11:28

look at all the cash that Nvidia has on

11:30

its balance sheet and the rumors about

11:32

them looking at other deals, I expect

11:34

this is just the beginning. I expect

11:35

they'll keep doing deals. Maybe not 20

11:37

billion, but I think they'll keep doing

11:38

big deals.

11:39

>> So interesting that we keep seeing this

11:41

theme that there is exactly you say the

11:43

reverse aqua hire theme. Um, I mean,

11:46

just thinking back to Microsoft and and

11:48

Inflection where the same thing

11:50

happened, um, and they have this deal

11:53

and then all of the talent goes over to

11:55

Microsoft and then what do you know? The

11:57

founder of Inflection is now the CEO of

11:59

Microsoft AI. And I assume something

12:01

similar is going to happen with Jonathan

12:02

Ross. Something so interesting that you

12:04

reported is that he told you that they

12:08

had no intention of being acquired. He

12:10

said, I read the quote that you

12:12

reported. He said to you, quote, "We

12:13

have no intention of being fake acquired

12:15

or real acquired for that matter." He

12:18

literally predicted precisely the

12:20

opposite of what happened.

12:22

>> Yeah.

12:22

>> What do you make of that?

12:23

>> I mean, I love it. You know, if a

12:25

founder tells me something like that and

12:26

I have the ability to remember, that's

12:29

the thing. I was like, it's harder to

12:30

remember these days. But when I

12:32

remember, oh, I had this conversation,

12:33

they said that, I dig it up. And yeah,

12:35

this was

12:36

>> over a year ago. You know, it was

12:37

actually the same day that Google

12:39

reverse Aqua hired Character AI, which

12:42

was something people have probably

12:43

forgotten about by now, but was another

12:45

one of these multi-billion dollar deals.

12:47

And um yeah, I asked him about it in the

12:50

interview that day and he was like,

12:51

"Yeah, we're not going to be fake

12:52

acquired." And then you know what? Uh I

12:54

$20 billion had something different, you

12:56

know, to say about that. I guess

12:57

everyone has their price, right?

12:59

>> Exactly. It seems like this this

13:01

continues to be the theme where as the

13:02

founder of an AI company, you're saying

13:04

we're going to take over the world.

13:05

We're going to take on big tech. we can

13:06

do it ourselves. And then someone shows

13:08

up with a ridiculously large bag of

13:11

money at which point you kind of shut

13:13

the [ __ ] up and take the money and you

13:14

go home.

13:15

>> I mean, we were talking about all this

13:17

just we were talking about all these,

13:18

you know, AI researcher comp packages

13:20

over the summer, right? With which Meta

13:22

was doing. Jonathan, the founder of

13:23

Grock, is probably considered top three

13:26

to five greatest minds in the world on

13:28

on chips. He's the only he invented the

13:30

TPU at Google. Uh he's invented the

13:33

Grock chip and now he's working at

13:35

Nvidia. So he's one of the only leaders

13:37

to have touched all kind of three major

13:39

major chips and uh I think he's for

13:41

Nvidia that's worth it.

13:43

>> Yeah. Um just final uh question before

13:46

you go. It's a new year 2026. If you had

13:50

to make predictions about what we will

13:52

see in the tech sector maybe like the

13:55

technology of the year. It sounds like

13:57

robotics is getting a lot of attention

14:00

>> uh at CES, but maybe it sounds like you

14:03

don't believe it it's going to really

14:04

come to fruition. What would be your

14:06

predictions for uh technology in 2026?

14:11

On the hardware side, I think AI

14:13

wearables we're only going to keep

14:15

hearing more about. I think we're

14:17

getting that here at CES. It's going to

14:18

start trickling out more. I think we

14:20

maybe will see a tease from OpenAI what

14:23

they've been up to with Johnny IV maybe

14:24

by the end of the year. And yeah, I

14:27

think Meta will ship stuff. Apple will

14:29

maybe tease stuff. Uh Snap will release

14:32

their glasses, the consumer version.

14:35

>> I do think that's on the hardware side.

14:36

That's the biggest thing I'm looking at.

14:38

And also all these like AI rings and

14:39

pendants and that's just everywhere here

14:42

at CES and I expect that to only get

14:44

bigger.

14:44

>> Okay, Alex Heath, appreciate your time.

14:48

Enjoy Vegas. And don't do too much

14:50

gambling. I know you love I know you're

14:52

a gambling man.

14:53

>> I'll be at room later tonight. Yeah, you

14:55

know me.

14:57

>> I love it. Okay, thanks Alex.

14:59

>> Thanks.

15:00

>> We'll be right back. And if you're

15:02

enjoying the show so far, be sure to

15:04

like and subscribe to the Prof Pod

15:06

YouTube channel at the link below.

15:27

We're back with Profy Markets.

15:29

Nova Nordisk launched the first ever

15:31

GLP1 pill this week, marking a new

15:34

chapter for obesity treatment in the US.

15:37

The Wiggoi pill is available now and it

15:40

costs between $149 and $299 per month,

15:44

which is a fraction of the price of

15:45

injectables. The company says that the

15:48

combination of lower pricing and easier

15:49

dosing could open new possibilities for

15:52

more than 100 million Americans living

15:54

with obesity. The stock is up 5% since

15:58

that announcement. To help us break down

16:01

what this means for Nova Nordisk, we're

16:03

speaking with Jared Holtz, healthcare

16:06

equity strategist at Mizuo. Jared,

16:09

thanks for joining us on Profit Markets.

16:11

>> Great to be here. Thanks a lot.

16:13

>> So, this GLP1 pill

16:17

uh has been launched by Novon Nordisk.

16:19

You can buy it today. Uh seems like

16:23

quite a significant development. Let's

16:25

just start with your initial reactions

16:28

to this move. Yeah, for sure. I've been

16:31

keeping a really close eye on on the

16:33

development of the oral pills for

16:35

obesity just given the fact that the

16:37

category the broader GLP-1 category is

16:41

expected to be north of 100 billion,

16:43

right? And and we know that the orals

16:45

are going to have a big piece of that. I

16:47

think when you go back and you kind of

16:49

consider some of the data sets that

16:51

we've seen out of Nova Nordisk, out of

16:53

Eli Lilly and others, it's been spotty

16:55

at times for the pill because the the

16:58

mechanism or the delivery is a little

16:59

bit different and we already have

17:01

awesome drugs on the market. So, it's

17:04

tough to know exactly where these are

17:07

going to fit, but it's a consumer

17:09

product at the end of the day, right? So

17:11

by virtue of that, the market is going

17:14

to be massive even if the drugs aren't

17:17

that great, I think.

17:18

>> Yeah. What are the differences between

17:20

the pill and the needle besides the

17:24

delivery? Is is the pill less effective?

17:27

Does it work differently in the body?

17:30

What's the difference?

17:31

>> I think the main thing is that the

17:32

halflife of the pill is so different

17:34

than the injectable, right? When you

17:35

take the the once weekly injectable,

17:38

you're looking at at a product that is

17:40

incredibly efficacious for most of that

17:43

week. And at the the back end of that

17:45

week, sometimes the effect waines a

17:47

little bit and patients that are on the

17:50

product get a little bit hungrier and

17:53

their side effects actually dissipate,

17:55

which is good and bad. And then when you

17:57

take it again, you kind of restart the

18:00

cycle. here when you're taking these

18:01

pills every day. I think there there's a

18:04

there's an issue here with can your body

18:07

absorb enough on any given day to kind

18:10

of really do the same um have the same

18:14

effect as the injection from an efficacy

18:16

standpoint without having the detriment

18:19

of side effects. because some of the

18:20

side effects that we've seen in the

18:22

pills have been worse, but we also

18:24

haven't really seen what a real life

18:27

patient may experience, which is to say

18:30

taking very small doses for a while

18:33

before then titrating up to higher

18:35

doses. We we really haven't seen a trial

18:37

run, I don't think, by any company

18:40

that's ideal or really will mirror what

18:43

we see in real life, which are patients

18:46

probably either opting to take the pill

18:49

because they're not that heavy and they

18:51

don't need a high dose or that have

18:54

already lost a lot of weight by taking a

18:57

drug from Novo or from Lily and kind of

19:00

just want to stabilize their w their

19:02

weight. We don't really know how this is

19:03

all going to work out, but there are

19:05

tens of millions of patients out there

19:07

that are that are kind of like in the

19:09

addressable market here. So, it I'm not

19:11

really sure it matters.

19:12

>> Yeah. Yeah. The the pricing is quite

19:15

interesting, too. Uh between 149 and 299

19:19

per month. Uh that's a fraction of the

19:23

price of the uh injectable. Uh what do

19:28

you make of that pricing? Well, the

19:30

injectable prices are coming down too.

19:32

So, I think in 6 months, 12 months, the

19:35

there might be a little bit more par.

19:38

Um, I think that the pricing allows

19:41

patients to get on it, especially those

19:43

that are going to have to pay out of

19:45

pocket, right? And that that's the

19:46

biggest piece of this is are do we do we

19:49

think that all of the patients that are

19:50

eligible are are going to get insured

19:52

for it? Likely not. But if your doctor

19:55

is willing to write a prescription for

19:57

it, even if you're not covered, for less

20:00

than 200 a month, you can get access. By

20:03

the way, the price of gyms in the United

20:05

States is well north of that for decent

20:06

ones, right? There are there are crappy

20:08

gyms that you can that you can uh go to

20:11

monthly for for less, but the good ones

20:13

are a lot more. So, if your if your

20:15

whole objective is to sort of just lose

20:18

10 lb, 20 lb, I think these injectables

20:21

are going to be, you know, very

20:23

significant really quickly. And that's

20:24

why I think it's super interesting for

20:26

Novo to be in this spot.

20:27

>> What do you think of the competition

20:28

that we're seeing in the oral uh GLP1

20:32

space? Eli Liy, for example, I know is

20:35

working on their own pill. What is the

20:38

competitive landscape look like? And

20:40

what do you think this means for Novo

20:42

Nordisk shareholders compared to say Eli

20:45

Liy shareholders? Well, it's really

20:46

interesting because when you look at

20:48

both when you look at the stocks

20:49

specifically, the expectations around

20:51

Lily's Oral or for Gibron and then the

20:54

oral we go out of Nova Nordis, the the

20:56

chasm between the two couldn't be

20:58

bigger, right? You've got one company

21:00

that's north of a trillion dollars in

21:02

market cap predicated mainly on their

21:05

GLP-1 drugs, whether it's the oral or or

21:07

the injectable and and obviously they

21:09

have a lot more in their portfolio, but

21:12

the stock movements on the back of

21:13

obesity have been the most pronounced by

21:15

far. Then you've got Novo Nordisk, which

21:17

is, you know, as of two weeks ago was

21:19

trading close to a 5-year low. So the

21:22

expectation gain between the two is so

21:25

pronounced as though no one thinks that

21:27

this oral we go is going to do anything

21:30

but or for glyip run is going to be

21:32

incredibly successful. So it's got to I

21:33

think it's going to be much more similar

21:36

than different and I think the data sets

21:38

are actually from an efficacy and safety

21:40

standpoint not that different either.

21:43

When the when the Lily data first came

21:45

out investors weren't that excited about

21:47

it. The stock dropped about 15 to 20%.

21:50

And then over time as the company kind

21:52

of explained how the trial worked and

21:55

the design and and how they put patients

21:56

on the drug, we we all became more

21:59

comfortable. But I think the

22:01

expectations around Novo specifically

22:04

are really really low. And I think

22:05

that's good. That's good for the stock.

22:08

>> Yeah. Yeah. Absolutely. I mean this and

22:11

this will be the final question. The

22:13

we've seen the hype cycle of the GLP1

22:17

industry kind of run its course. it sort

22:20

of hit that peak and then suddenly

22:22

people kind of went, "Oh, maybe this

22:23

isn't going to happen the way we thought

22:25

it would." Um, and it sort of waned

22:27

again and it's definitely reflected in

22:29

the stock price of Nova Nordisk. Do you

22:32

think that we could be in for a reversal

22:35

again? Are we about to maybe hit another

22:38

phase of interest and excitement for

22:41

this industry?

22:42

>> Yeah, I I don't really know where we are

22:44

in the cycle. I mean I it felt like

22:45

midway through last year the the waning

22:48

aspect that you talked about was right

22:51

and then as we got further in the year

22:52

with or forgi data Lily hitting a

22:55

trillion in cap metah getting acquired

22:58

by fizer in that bidding war which was

23:00

very strange and then the structure data

23:03

at the end of the year. I think we're

23:05

we're still in a pocket where I think

23:07

there's a lot of excitement. But what

23:08

could get excitement for Novo

23:10

specifically would be if the Oro GOI

23:14

started to take off and the market share

23:17

disparity between it and Lily kind of

23:20

compress us a little bit. That's what's

23:21

really going to take Novo up.

23:23

>> Okay. Jared Holtz, healthcare equity

23:25

strategist at Mizuo. Jared, really

23:28

appreciate your time.

23:29

>> Great to be with you. Thanks a lot.

23:30

Well, GLP-1 drugs have come a long way

23:32

since they were first introduced,

23:34

believe it or not, in 2005. It was

23:37

originally intended to treat diabetes

23:39

and then we learned it could treat

23:40

obesity too. Then Ompic came along, then

23:43

Wiggoi, then Munjaro, then Zepbound and

23:47

now we have reached a point at which 1

23:49

in 8 Americans currently use GLP1. So

23:54

that is more than 40 million people.

23:56

It's more than the population of Canada.

23:58

Now, many people have said that we might

24:00

have hit peak GLP1, that yes, GLP1s

24:04

might be a big deal, but maybe they're

24:06

not as big a deal as we once thought.

24:10

However, we believe that this story is

24:12

actually just getting started. Because

24:14

our view is that despite the incredible

24:17

adoption we've seen over the past few

24:19

years, the reality is GLP1 still face

24:23

significant barriers to entry. And of

24:26

those barriers, one of the biggest is

24:29

the fact that in order to take it, you

24:31

have to stick a needle in your leg. Now,

24:33

for some people that might not be a big

24:35

deal, but for many people it is a big

24:38

deal. In fact, it is a big deal for most

24:40

people. It turns out 63% of adults say

24:44

they experience some level of needle

24:47

phobia, i.e. they hate needles. And of

24:50

those needle phobes, more than half say

24:53

that they will actively avoid having

24:55

their blood drawn because of needles.

24:58

Meanwhile, roughly a third of them say

25:00

they actively avoid getting vaccinated

25:03

because of needles. So if a third of the

25:05

entire adult population isn't getting

25:09

their blood drawn because they're scared

25:11

of needles, well then the obvious

25:12

question is what percentage of the

25:14

population isn't taking GLP-1 drugs for

25:18

the same reason? Is it also a third? Is

25:22

it half? Is it higher than half? What we

25:25

have here is a seemingly small and

25:28

uninteresting issue, which is in fact a

25:31

pretty gigantic issue. And as of this

25:35

week, with the release of this new pill,

25:37

that issue has been eliminated. You can

25:40

now take a drug that helps you lose

25:42

dramatic amounts of weight. And it is

25:44

functionally no different from popping

25:47

an Advil. That is a really big deal. And

25:50

when you live in a country where 40% of

25:52

the population is already obese, you

25:55

have to think that that 1 in8 number is

25:58

about to go way higher. Now, to be

26:01

clear, Nova Nordisk isn't the only

26:03

winner here. As we've discussed, Eli Liy

26:05

is also getting approval for their

26:08

weight loss pill, which will likely

26:09

launch in the next few months or so.

26:11

There are also plenty of Chinese

26:12

companies that are working on their own

26:15

GLP-1 pill. that this is becoming a

26:17

crowded space and our point here isn't

26:19

to just go and buy Nova Nordisk. No, our

26:22

point is a lot broader than that. Our

26:25

point is that GLP1s are just getting

26:28

started right now. Or at least that is

26:30

our thesis. And now that this pill is

26:33

out, now that it is readily available

26:35

across the US, that thesis will be put

26:39

to the test.

26:41

Thanks for listening to Profit Markets

26:43

from Profit Media. If you liked what you

26:45

heard, subscribe to our YouTube channel

26:47

and tune in tomorrow for more.

Interactive Summary

The video discusses major market activities and highlights from the Consumer Electronics Show (CES) in Las Vegas. Nvidia dominated CES headlines with its new Reuben chip and AI models for autonomous vehicles, strategically using these ventures for data to inform future chip development. A significant trend discussed is the 'reverse acquihire,' exemplified by Nvidia's $20 billion deal with Groq, primarily to acquire top talent like Jonathan Ross to address AI inference issues. Predictions for 2026 tech emphasize the rise of AI wearables. The second half of the video focuses on Nova Nordisk's launch of the first GLP-1 pill for obesity, priced significantly lower than injectables. This development aims to overcome needle phobia, a major barrier, and expand market access, signaling that the GLP-1 market is just beginning despite existing competition from companies like Eli Lilly.

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