CML is kind of the predominant molecule

that that gets formed in this

extracellular matrix that's driving

aging and nothing breaks it down. So,

these scientists set out to try and

create an enzyme. An enzyme is a protein

that breaks something down that can

break down CML. And so, these guys kind

of went out and they took the target,

which is CML and tried to figure out,

okay, how do we actually degrade CML,

clear that extracellular matrix and

reverse aging. They started to test it

on the proteins that we would find in

our body, casein, collagen, retinal

proteins, which are in your eye,

hemoglobin, and they were able to get

rid of 52 to 97%

of the CML. Just degrade it away.

And then they they found several sites

where they were able to degrade over 90%

and then they took actual human skin

from elderly patients that had donated

their skin and they put this enzyme onto

that skin and they were able to

eliminate 55% of the CML on the skin,

basically reverse the skin's age down to

the age of a 31-year-old. This is from

greater than 70-year-old patients just

by putting this enzyme on the skin. And

so, it's kind of a groundbreaking

demonstration of combination of

AlphaFold, what's called directed

evolution, where you change the order of

the DNA that changes the structure of

the protein to test different proteins,

do high-throughput screening, and

ultimately make a novel protein that

doesn't exist in nature today that can

do something pretty profound for human

health.

>> It will be a trillion-dollar market.

>> [laughter]

>> Yeah. You can create a cream

>> if you could put this enzyme literally

on your skin and have it absorbed in

>> cream.

>> Yeah.

>> Game over.

>> Unbelievable.

>> That alone is $2 trillion.